HMGB2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HMGB2
Entrez Gene ID	3148
Full Name	high mobility group box 2
Synonyms	HMG2
General protein information	Preferred Names high mobility group box 2 Names high mobility group protein B2 HMG-2 high mobility group protein 2 high-mobility group (nonhistone chromosomal) protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q34.1
Summary	This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008].
Disorder MIM:	163906

mRNA and Protein(s)

mRNA	Protein	Name
NM_001130688.1	NP_001124160.1	high mobility group protein B2
NM_001130689.1	NP_001124161.1	high mobility group protein B2
NM_002129.4	NP_002120.1	high mobility group protein B2
NM_002129.3	NP_002120.1	high mobility group protein B2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Hmgb2	NP_032278.1
Danio rerio (zebrafish)	hmgb2a	NP_001032501.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000005	XP_311155.4
Caenorhabditis elegans (roundworm)	hmg-1.2	NP_001022600.1
Bos taurus (cattle)	HMGB2	NP_001032705.1
Gallus gallus (chicken)	HMGB2	NP_990817.1
Drosophila melanogaster (fruit fly)	Dsp1	NP_001138203.1
Canis lupus familiaris (dog)	HMGB2	XP_543194.2
Homo sapiens (human)	HMGB2	NP_002120.1
Pan troglodytes (chimpanzee)	HMGB2	XP_517538.3
	LOC697057	XP_001085665.1

Gene Ontology
Bibliography

Related articles in PubMed

HMGB proteins and arthritis.
Taniguchi N, Kawakami Y, Maruyama I, Lotz M
Human cell31(1)1-9(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identified the oncogene HMGB2 as a downstream target of miR-130a by using luciferase and western blot assays. Knockdown of HMGB2 mimicked the effect of miR-130a in glioma cells.
Title: Downregulation of miR-130a promotes cell growth and epithelial to mesenchymal transition by activating HMGB2 in glioma.

Serum HMGB2 levels were associated with in-stent restenosis in patients.
Title: Association of Serum HMGB2 Levels With In-Stent Restenosis: HMGB2 Promotes Neointimal Hyperplasia in Mice With Femoral Artery Injury and Proliferation and Migration of VSMCs.

downregulation of HMGB1 and/or HMGB2 in undifferentiated human embryonic stem cells does not affect the stemness of cells.
Title: Properties of Human Embryonic Stem Cells and Their Differentiated Derivatives Depend on Nonhistone DNA-Binding HMGB1 and HMGB2 Proteins.

Data indicate the function of high mobility group box 2 (HMGB2) in glycolytic control in pancreatic cancer.
Title: Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer.

results establish HMGB2 as a novel master regulator that orchestrates senescence-associated secretory phenotype.
Title: HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci.

The following HMGB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HMGB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13615	NM_001130688.1 Latest version!	Homo sapiens high mobility group box 2 (HMGB2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu13615	NM_002129.4 Latest version!	Homo sapiens high mobility group box 2 (HMGB2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu13615	NM_001130689.1 Latest version!	Homo sapiens high mobility group box 2 (HMGB2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13615	NM_002129.3	Homo sapiens high mobility group box 2 (HMGB2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HMGB2 ( NM_001130688.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001124160.1 Homo sapiens high mobility group box 2 (HMGB2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13615
Clone ID Related Accession (Same CDS sequence)	NM_001130688.1 , NM_001130689.1 , NM_002129.4 , NM_002129.3
Accession Version	NM_001130688.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	high mobility group protein B2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK311864.1, BM727941.1 and AA576809.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK311864.1, SRR1163657.301936.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2150385 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTAAAG GAGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GGGAAGAGCA CAAGAAGAAA CACCCGGACT CTTCCGTCAA TTTCGCGGAA 
TTCTCCAAGA AGTGTTCGGA GAGATGGAAG ACCATGTCTG CAAAGGAGAA GTCGAAGTTT 
GAAGATATGG CAAAAAGTGA CAAAGCTCGC TATGACAGGG AGATGAAAAA TTACGTTCCT 
CCCAAAGGTG ATAAGAAGGG GAAGAAAAAG GACCCCAATG CTCCTAAAAG GCCACCATCT 
GCCTTCTTCC TGTTTTGCTC TGAACATCGC CCAAAGATCA AAAGTGAACA CCCTGGCCTA 
TCCATTGGGG ATACTGCAAA GAAATTGGGT GAAATGTGGT CTGAGCAGTC AGCCAAAGAT 
AAACAACCAT ATGAACAGAA AGCAGCTAAG CTAAAGGAGA AATATGAAAA GGATATTGCT 
GCATATCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GCCCTGGCAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAGG AGGAAGAAGA AGATGAAGAT 
GAGGAGGAAG AGGATGAAGA TGAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001124160.1
CDS	134..763
Translation	MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE

Target ORF information:

RefSeq Version	NM_001130688.1
Organism	Homo sapiens(human)
Definition	Homo sapiens high mobility group box 2 (HMGB2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130688.1

ORF Insert Sequence:

ATGGGTAAAG GAGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GGGAAGAGCA CAAGAAGAAA CACCCGGACT CTTCCGTCAA TTTCGCGGAA 
TTCTCCAAGA AGTGTTCGGA GAGATGGAAG ACCATGTCTG CAAAGGAGAA GTCGAAGTTT 
GAAGATATGG CAAAAAGTGA CAAAGCTCGC TATGACAGGG AGATGAAAAA TTACGTTCCT 
CCCAAAGGTG ATAAGAAGGG GAAGAAAAAG GACCCCAATG CTCCTAAAAG GCCACCATCT 
GCCTTCTTCC TGTTTTGCTC TGAACATCGC CCAAAGATCA AAAGTGAACA CCCTGGCCTA 
TCCATTGGGG ATACTGCAAA GAAATTGGGT GAAATGTGGT CTGAGCAGTC AGCCAAAGAT 
AAACAACCAT ATGAACAGAA AGCAGCTAAG CTAAAGGAGA AATATGAAAA GGATATTGCT 
GCATATCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GCCCTGGCAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAGG AGGAAGAAGA AGATGAAGAT 
GAGGAGGAAG AGGATGAAGA TGAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HMGB2 ( NM_001130689.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001124161.1 Homo sapiens high mobility group box 2 (HMGB2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu13615
Clone ID Related Accession (Same CDS sequence)	NM_001130688.1 , NM_001130689.1 , NM_002129.4 , NM_002129.3
Accession Version	NM_001130689.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	high mobility group protein B2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM781845.1, AC097534.3, BM727941.1 and AA576809.1. Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.387981.1, SRR1163655.113134.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2150385 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTAAAG GAGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GGGAAGAGCA CAAGAAGAAA CACCCGGACT CTTCCGTCAA TTTCGCGGAA 
TTCTCCAAGA AGTGTTCGGA GAGATGGAAG ACCATGTCTG CAAAGGAGAA GTCGAAGTTT 
GAAGATATGG CAAAAAGTGA CAAAGCTCGC TATGACAGGG AGATGAAAAA TTACGTTCCT 
CCCAAAGGTG ATAAGAAGGG GAAGAAAAAG GACCCCAATG CTCCTAAAAG GCCACCATCT 
GCCTTCTTCC TGTTTTGCTC TGAACATCGC CCAAAGATCA AAAGTGAACA CCCTGGCCTA 
TCCATTGGGG ATACTGCAAA GAAATTGGGT GAAATGTGGT CTGAGCAGTC AGCCAAAGAT 
AAACAACCAT ATGAACAGAA AGCAGCTAAG CTAAAGGAGA AATATGAAAA GGATATTGCT 
GCATATCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GCCCTGGCAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAGG AGGAAGAAGA AGATGAAGAT 
GAGGAGGAAG AGGATGAAGA TGAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001124161.1
CDS	121..750
Translation	MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE

Target ORF information:

RefSeq Version	NM_001130689.1
Organism	Homo sapiens(human)
Definition	Homo sapiens high mobility group box 2 (HMGB2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130689.1

ORF Insert Sequence:

ATGGGTAAAG GAGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GGGAAGAGCA CAAGAAGAAA CACCCGGACT CTTCCGTCAA TTTCGCGGAA 
TTCTCCAAGA AGTGTTCGGA GAGATGGAAG ACCATGTCTG CAAAGGAGAA GTCGAAGTTT 
GAAGATATGG CAAAAAGTGA CAAAGCTCGC TATGACAGGG AGATGAAAAA TTACGTTCCT 
CCCAAAGGTG ATAAGAAGGG GAAGAAAAAG GACCCCAATG CTCCTAAAAG GCCACCATCT 
GCCTTCTTCC TGTTTTGCTC TGAACATCGC CCAAAGATCA AAAGTGAACA CCCTGGCCTA 
TCCATTGGGG ATACTGCAAA GAAATTGGGT GAAATGTGGT CTGAGCAGTC AGCCAAAGAT 
AAACAACCAT ATGAACAGAA AGCAGCTAAG CTAAAGGAGA AATATGAAAA GGATATTGCT 
GCATATCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GCCCTGGCAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAGG AGGAAGAAGA AGATGAAGAT 
GAGGAGGAAG AGGATGAAGA TGAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HMGB2 ( NM_002129.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002120.1 Homo sapiens high mobility group box 2 (HMGB2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13615
Clone ID Related Accession (Same CDS sequence)	NM_001130688.1 , NM_001130689.1 , NM_002129.4 , NM_002129.3
Accession Version	NM_002129.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	high mobility group protein B2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC097534.3, BM727941.1 and AA576809.1. On May 17, 2019 this sequence version replaced NM_002129.3. Transcript Variant: This variant (1) represents the longest transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189658.83467.1, SRR5189658.133062.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2150385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000296503.10/ ENSP00000296503.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGTAAAG GAGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GGGAAGAGCA CAAGAAGAAA CACCCGGACT CTTCCGTCAA TTTCGCGGAA 
TTCTCCAAGA AGTGTTCGGA GAGATGGAAG ACCATGTCTG CAAAGGAGAA GTCGAAGTTT 
GAAGATATGG CAAAAAGTGA CAAAGCTCGC TATGACAGGG AGATGAAAAA TTACGTTCCT 
CCCAAAGGTG ATAAGAAGGG GAAGAAAAAG GACCCCAATG CTCCTAAAAG GCCACCATCT 
GCCTTCTTCC TGTTTTGCTC TGAACATCGC CCAAAGATCA AAAGTGAACA CCCTGGCCTA 
TCCATTGGGG ATACTGCAAA GAAATTGGGT GAAATGTGGT CTGAGCAGTC AGCCAAAGAT 
AAACAACCAT ATGAACAGAA AGCAGCTAAG CTAAAGGAGA AATATGAAAA GGATATTGCT 
GCATATCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GCCCTGGCAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAGG AGGAAGAAGA AGATGAAGAT 
GAGGAGGAAG AGGATGAAGA TGAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002120.1
CDS	108..737
Translation	MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE

Target ORF information:

RefSeq Version	NM_002129.4
Organism	Homo sapiens(human)
Definition	Homo sapiens high mobility group box 2 (HMGB2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002129.4

ORF Insert Sequence:

ATGGGTAAAG GAGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GGGAAGAGCA CAAGAAGAAA CACCCGGACT CTTCCGTCAA TTTCGCGGAA 
TTCTCCAAGA AGTGTTCGGA GAGATGGAAG ACCATGTCTG CAAAGGAGAA GTCGAAGTTT 
GAAGATATGG CAAAAAGTGA CAAAGCTCGC TATGACAGGG AGATGAAAAA TTACGTTCCT 
CCCAAAGGTG ATAAGAAGGG GAAGAAAAAG GACCCCAATG CTCCTAAAAG GCCACCATCT 
GCCTTCTTCC TGTTTTGCTC TGAACATCGC CCAAAGATCA AAAGTGAACA CCCTGGCCTA 
TCCATTGGGG ATACTGCAAA GAAATTGGGT GAAATGTGGT CTGAGCAGTC AGCCAAAGAT 
AAACAACCAT ATGAACAGAA AGCAGCTAAG CTAAAGGAGA AATATGAAAA GGATATTGCT 
GCATATCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GCCCTGGCAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAGG AGGAAGAAGA AGATGAAGAT 
GAGGAGGAAG AGGATGAAGA TGAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HMGB2 ( NM_002129.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002120.1 Homo sapiens high mobility group box 2 (HMGB2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13615
Clone ID Related Accession (Same CDS sequence)	NM_001130688.1 , NM_001130689.1 , NM_002129.4 , NM_002129.3
Accession Version	NM_002129.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	high mobility group protein B2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC097534.3, BM727941.1 and AA576809.1. On Jul 30, 2008 this sequence version replaced NM_002129.2. Transcript Variant: This variant (1) represents the longest transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.40174.1, SRR1660805.320203.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2150385 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTAAAG GAGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GGGAAGAGCA CAAGAAGAAA CACCCGGACT CTTCCGTCAA TTTCGCGGAA 
TTCTCCAAGA AGTGTTCGGA GAGATGGAAG ACCATGTCTG CAAAGGAGAA GTCGAAGTTT 
GAAGATATGG CAAAAAGTGA CAAAGCTCGC TATGACAGGG AGATGAAAAA TTACGTTCCT 
CCCAAAGGTG ATAAGAAGGG GAAGAAAAAG GACCCCAATG CTCCTAAAAG GCCACCATCT 
GCCTTCTTCC TGTTTTGCTC TGAACATCGC CCAAAGATCA AAAGTGAACA CCCTGGCCTA 
TCCATTGGGG ATACTGCAAA GAAATTGGGT GAAATGTGGT CTGAGCAGTC AGCCAAAGAT 
AAACAACCAT ATGAACAGAA AGCAGCTAAG CTAAAGGAGA AATATGAAAA GGATATTGCT 
GCATATCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GCCCTGGCAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAGG AGGAAGAAGA AGATGAAGAT 
GAGGAGGAAG AGGATGAAGA TGAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002120.1
CDS	194..823
Translation	MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE

Target ORF information:

RefSeq Version	NM_002129.3
Organism	Homo sapiens(human)
Definition	Homo sapiens high mobility group box 2 (HMGB2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002129.3

ORF Insert Sequence:

ATGGGTAAAG GAGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GGGAAGAGCA CAAGAAGAAA CACCCGGACT CTTCCGTCAA TTTCGCGGAA 
TTCTCCAAGA AGTGTTCGGA GAGATGGAAG ACCATGTCTG CAAAGGAGAA GTCGAAGTTT 
GAAGATATGG CAAAAAGTGA CAAAGCTCGC TATGACAGGG AGATGAAAAA TTACGTTCCT 
CCCAAAGGTG ATAAGAAGGG GAAGAAAAAG GACCCCAATG CTCCTAAAAG GCCACCATCT 
GCCTTCTTCC TGTTTTGCTC TGAACATCGC CCAAAGATCA AAAGTGAACA CCCTGGCCTA 
TCCATTGGGG ATACTGCAAA GAAATTGGGT GAAATGTGGT CTGAGCAGTC AGCCAAAGAT 
AAACAACCAT ATGAACAGAA AGCAGCTAAG CTAAAGGAGA AATATGAAAA GGATATTGCT 
GCATATCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GCCCTGGCAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAGG AGGAAGAAGA AGATGAAGAT 
GAGGAGGAAG AGGATGAAGA TGAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HMGB proteins and arthritis.
Human cell31(1)1-9(2018 Jan)
Taniguchi N,Kawakami Y,Maruyama I,Lotz M

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HMGB2 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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