HLA-DRB4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HLA-DRB4
Entrez Gene ID	3126
Full Name	major histocompatibility complex, class II, DR beta 4
Synonyms	DR4,DRB4,HLA-DR4B
General protein information	Preferred Names major histocompatibility complex, class II, DR beta 4 Names major histocompatibility complex, class II, DR beta 4 HLA class II histocompatibility antigen, DR beta 4 chain MHC class II antigen DRB4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.3
Summary	HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017030290.2	XP_016885779.1	major histocompatibility complex, class II, DR beta 4 isoform X4
XM_017030291.1	XP_016885780.1	major histocompatibility complex, class II, DR beta 4 isoform X5
XM_017030290.1	XP_016885779.1	major histocompatibility complex, class II, DR beta 4 isoform X4
XM_011548127.2	XP_011546429.1	major histocompatibility complex, class II, DR beta 4 isoform X1
XM_011548128.2	XP_011546430.1	major histocompatibility complex, class II, DR beta 4 isoform X2
XM_024452550.1	XP_024308318.1	major histocompatibility complex, class II, DR beta 4 isoform X6
NM_021983.4	NP_068818.4	major histocompatibility complex, class II, DR beta 4 precursor
XM_011548129.2	XP_011546431.1	major histocompatibility complex, class II, DR beta 4 isoform X3

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

A humanized HLA-DR4 mouse model for autoimmune myocarditis.
?elli ME, Thomas AC, Wraith DC, Newby AC
Journal of molecular and cellular cardiology10722-26(2017 Jun)

Anti-LGI1 encephalitis is strongly associated with HLA-DR7 and HLA-DRB4.
van Sonderen A, Roelen DL, Stoop JA, Verdijk RM, Haasnoot GW, Thijs RD, Wirtz PW, Schreurs MW, Claas FH, Sillevis Smitt PA, Titulaer MJ
Annals of neurology81(2)193-198(2017 Feb)

The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model.
Yuksel M, Xiao X, Tai N, Vijay GM, G?lden E, Beland K, Lapierre P, Alvarez F, Hu Z, Colle I, Ma Y, Wen L
Clinical and experimental immunology186(2)164-176(2016 Nov)

Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes.
Zhao LP, Alshiekh S, Zhao M, Carlsson A, Larsson HE, Forsander G, Ivarsson SA, Ludvigsson J, Kockum I, Marcus C, Persson M, Samuelsson U, ?rtqvist E, Pyo CW, Nelson WC, Geraghty DE, Lernmark ?,
Diabetes65(3)710-8(2016 Mar)

HLA-DR4-associated T and B cell responses to specific determinants on the IA-2 autoantigen in type 1 diabetes.
McLaughlin KA, Gulati K, Richardson CC, Morgan D, Bodansky HJ, Feltbower RG, Christie MR
Journal of immunology (Baltimore, Md. : 1950)193(9)4448-56(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Strong association of nontumor anti-LGI1 encephalitis with HLA-DRB4.
Title: Anti-LGI1 encephalitis is strongly associated with HLA-DR7 and HLA-DRB4.

HLA-DR4 is a susceptibility factor for the development of AIH. Impaired suppressive function of Tregs and reduced PD-1 expression may result in spontaneous activation of key immune cell subsets, such as antigen-presenting cells and CD8(+) T effectors, facilitating the induction of AIH and persistent liver damage.
Title: The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model.

HLA-DRB4 affects type 1 diabetes risk and islet autoantibodies.
Title: Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes.

The study identifies a region of focus for B and T cell responses to IA-2 in HLA-DR4 diabetic patients that may explain HLA associations of IA-2 autoantibodies.
Title: HLA-DR4-associated T and B cell responses to specific determinants on the IA-2 autoantigen in type 1 diabetes.

HLA-DR4 codes for susceptibility to RF+ polyarticular JIA with a six-fold risk.
Title: HLA-DR typing in polyarticular juvenile idiopathic arthritis: a study from a tertiary care hospital in northern India.

The following HLA-DRB4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HLA-DRB4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03605	NM_021983.4 Latest version!	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu03605	XM_017030290.2 Latest version!	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu58248	XM_011548127.2 Latest version!	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu58249	XM_011548128.2 Latest version!	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu58250	XM_011548129.2 Latest version!	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu58247	XM_024452550.1 Latest version!	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X7, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu99647	XM_017030291.1 Latest version!	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu03605	XM_017030290.1	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HLA-DRB4 ( NM_021983.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_068818.4 Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), mRNA.

Price & Availability↑

CloneID	OHu03605
Clone ID Related Accession (Same CDS sequence)	XM_017030290.2 , XM_017030290.1 , NM_021983.4
Accession Version	NM_021983.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 801bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	major histocompatibility complex, class II, DR beta 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF974249.1, BC005312.1 and AI829825.1. On or before Mar 23, 2015 this sequence version replaced XM_011548130.1, XM_006725948.1, XM_940103.2, NM_021983.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005312.1, AK292151.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGTGTC TGAAGCTCCC TGGAGGCTCC TGTATGGCAG CGCTGACAGT GACATTGACG 
GTGCTGAGCT CCCCACTGGC TTTGGCTGGG GACACCCAAC CACGTTTCTT GGAGCAGGCT 
AAGTGTGAGT GTCATTTCCT CAATGGGACG GAGCGAGTGT GGAACCTGAT CAGATACATC 
TATAACCAAG AGGAGTACGC GCGCTACAAC AGTGACCTGG GGGAGTACCA GGCGGTGACG 
GAGCTGGGGC GGCCTGACGC TGAGTACTGG AACAGCCAGA AGGACCTCCT GGAGCGGAGG 
CGGGCCGAGG TGGACACCTA CTGCAGATAC AACTACGGGG TTGTGGAGAG CTTCACAGTG 
CAGCGGCGAG TCCAACCTAA GGTGACTGTG TATCCTTCAA AGACCCAGCC CCTGCAGCAC 
CACAACCTCC TGGTCTGCTC TGTGAATGGT TTCTATCCAG GCAGCATTGA AGTCAGGTGG 
TTCCGGAACG GCCAGGAAGA GAAGGCTGGG GTGGTGTCCA CAGGCCTGAT CCAGAATGGA 
GACTGGACCT TCCAGACCCT GGTGATGCTG GAAACAGTTC CTCGGAGTGG AGAGGTTTAC 
ACCTGCCAAG TGGAGCATCC AAGCATGATG AGCCCTCTCA CGGTGCAATG GAGTGCACGG 
TCTGAATCTG CACAGAGCAA GATGCTGAGT GGAGTCGGGG GCTTTGTGCT GGGCCTGCTC 
TTCCTTGGGA CAGGGCTGTT CATCTACTTC AGGAATCAGA AAGGACACTC TGGACTTCAG 
CCAACAGGAC TCTTGAGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068818.4
CDS	72..872
Translation	MVCLKLPGGSCMAALTVTLTVLSSPLALAGDTQPRFLEQAKCECHFLNGTERVWNLIRYIYNQEEYARYNSDLGEYQAVTELGRPDAEYWNSQKDLLERRRAEVDTYCRYNYGVVESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVNGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSMMSPLTVQWSARSESAQSKMLSGVGGFVLGLLFLGTGLFIYFRNQKGHSGLQPTGLLS

Target ORF information:

RefSeq Version	NM_021983.4
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021983.4

ORF Insert Sequence:

ATGGTGTGTC TGAAGCTCCC TGGAGGCTCC TGTATGGCAG CGCTGACAGT GACATTGACG 
GTGCTGAGCT CCCCACTGGC TTTGGCTGGG GACACCCAAC CACGTTTCTT GGAGCAGGCT 
AAGTGTGAGT GTCATTTCCT CAATGGGACG GAGCGAGTGT GGAACCTGAT CAGATACATC 
TATAACCAAG AGGAGTACGC GCGCTACAAC AGTGACCTGG GGGAGTACCA GGCGGTGACG 
GAGCTGGGGC GGCCTGACGC TGAGTACTGG AACAGCCAGA AGGACCTCCT GGAGCGGAGG 
CGGGCCGAGG TGGACACCTA CTGCAGATAC AACTACGGGG TTGTGGAGAG CTTCACAGTG 
CAGCGGCGAG TCCAACCTAA GGTGACTGTG TATCCTTCAA AGACCCAGCC CCTGCAGCAC 
CACAACCTCC TGGTCTGCTC TGTGAATGGT TTCTATCCAG GCAGCATTGA AGTCAGGTGG 
TTCCGGAACG GCCAGGAAGA GAAGGCTGGG GTGGTGTCCA CAGGCCTGAT CCAGAATGGA 
GACTGGACCT TCCAGACCCT GGTGATGCTG GAAACAGTTC CTCGGAGTGG AGAGGTTTAC 
ACCTGCCAAG TGGAGCATCC AAGCATGATG AGCCCTCTCA CGGTGCAATG GAGTGCACGG 
TCTGAATCTG CACAGAGCAA GATGCTGAGT GGAGTCGGGG GCTTTGTGCT GGGCCTGCTC 
TTCCTTGGGA CAGGGCTGTT CATCTACTTC AGGAATCAGA AAGGACACTC TGGACTTCAG 
CCAACAGGAC TCTTGAGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HLA-DRB4 ( XM_017030290.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885779.1 Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X5, mRNA.

Price & Availability↑

CloneID	OHu03605
Clone ID Related Accession (Same CDS sequence)	XM_017030290.2 , XM_017030290.1 , NM_021983.4
Accession Version	XM_017030290.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 801bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-12
Organism	Homo sapiens(human)
Product	major histocompatibility complex, class II, DR beta 4 isoform X4
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167247.2) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017030290.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END##

ATGGTGTGTC TGAAGCTCCC TGGAGGCTCC TGTATGGCAG CGCTGACAGT GACATTGACG 
GTGCTGAGCT CCCCACTGGC TTTGGCTGGG GACACCCAAC CACGTTTCTT GGAGCAGGCT 
AAGTGTGAGT GTCATTTCCT CAATGGGACG GAGCGAGTGT GGAACCTGAT CAGATACATC 
TATAACCAAG AGGAGTACGC GCGCTACAAC AGTGACCTGG GGGAGTACCA GGCGGTGACG 
GAGCTGGGGC GGCCTGACGC TGAGTACTGG AACAGCCAGA AGGACCTCCT GGAGCGGAGG 
CGGGCCGAGG TGGACACCTA CTGCAGATAC AACTACGGGG TTGTGGAGAG CTTCACAGTG 
CAGCGGCGAG TCCAACCTAA GGTGACTGTG TATCCTTCAA AGACCCAGCC CCTGCAGCAC 
CACAACCTCC TGGTCTGCTC TGTGAATGGT TTCTATCCAG GCAGCATTGA AGTCAGGTGG 
TTCCGGAACG GCCAGGAAGA GAAGGCTGGG GTGGTGTCCA CAGGCCTGAT CCAGAATGGA 
GACTGGACCT TCCAGACCCT GGTGATGCTG GAAACAGTTC CTCGGAGTGG AGAGGTTTAC 
ACCTGCCAAG TGGAGCATCC AAGCATGATG AGCCCTCTCA CGGTGCAATG GAGTGCACGG 
TCTGAATCTG CACAGAGCAA GATGCTGAGT GGAGTCGGGG GCTTTGTGCT GGGCCTGCTC 
TTCCTTGGGA CAGGGCTGTT CATCTACTTC AGGAATCAGA AAGGACACTC TGGACTTCAG 
CCAACAGGAC TCTTGAGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885779.1
CDS	102..902
Translation	MVCLKLPGGSCMAALTVTLTVLSSPLALAGDTQPRFLEQAKCECHFLNGTERVWNLIRYIYNQEEYARYNSDLGEYQAVTELGRPDAEYWNSQKDLLERRRAEVDTYCRYNYGVVESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVNGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSMMSPLTVQWSARSESAQSKMLSGVGGFVLGLLFLGTGLFIYFRNQKGHSGLQPTGLLS

Target ORF information:

RefSeq Version	XM_017030290.2
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017030290.2

ORF Insert Sequence:

ATGGTGTGTC TGAAGCTCCC TGGAGGCTCC TGTATGGCAG CGCTGACAGT GACATTGACG 
GTGCTGAGCT CCCCACTGGC TTTGGCTGGG GACACCCAAC CACGTTTCTT GGAGCAGGCT 
AAGTGTGAGT GTCATTTCCT CAATGGGACG GAGCGAGTGT GGAACCTGAT CAGATACATC 
TATAACCAAG AGGAGTACGC GCGCTACAAC AGTGACCTGG GGGAGTACCA GGCGGTGACG 
GAGCTGGGGC GGCCTGACGC TGAGTACTGG AACAGCCAGA AGGACCTCCT GGAGCGGAGG 
CGGGCCGAGG TGGACACCTA CTGCAGATAC AACTACGGGG TTGTGGAGAG CTTCACAGTG 
CAGCGGCGAG TCCAACCTAA GGTGACTGTG TATCCTTCAA AGACCCAGCC CCTGCAGCAC 
CACAACCTCC TGGTCTGCTC TGTGAATGGT TTCTATCCAG GCAGCATTGA AGTCAGGTGG 
TTCCGGAACG GCCAGGAAGA GAAGGCTGGG GTGGTGTCCA CAGGCCTGAT CCAGAATGGA 
GACTGGACCT TCCAGACCCT GGTGATGCTG GAAACAGTTC CTCGGAGTGG AGAGGTTTAC 
ACCTGCCAAG TGGAGCATCC AAGCATGATG AGCCCTCTCA CGGTGCAATG GAGTGCACGG 
TCTGAATCTG CACAGAGCAA GATGCTGAGT GGAGTCGGGG GCTTTGTGCT GGGCCTGCTC 
TTCCTTGGGA CAGGGCTGTT CATCTACTTC AGGAATCAGA AAGGACACTC TGGACTTCAG 
CCAACAGGAC TCTTGAGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HLA-DRB4 ( XM_017030290.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885779.1 Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X5, mRNA.

Price & Availability↑

CloneID	OHu03605
Clone ID Related Accession (Same CDS sequence)	XM_017030290.2 , XM_017030290.1 , NM_021983.4
Accession Version	XM_017030290.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 801bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	major histocompatibility complex, class II, DR beta 4 isoform X4
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167247.2) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGTGTC TGAAGCTCCC TGGAGGCTCC TGTATGGCAG CGCTGACAGT GACATTGACG 
GTGCTGAGCT CCCCACTGGC TTTGGCTGGG GACACCCAAC CACGTTTCTT GGAGCAGGCT 
AAGTGTGAGT GTCATTTCCT CAATGGGACG GAGCGAGTGT GGAACCTGAT CAGATACATC 
TATAACCAAG AGGAGTACGC GCGCTACAAC AGTGACCTGG GGGAGTACCA GGCGGTGACG 
GAGCTGGGGC GGCCTGACGC TGAGTACTGG AACAGCCAGA AGGACCTCCT GGAGCGGAGG 
CGGGCCGAGG TGGACACCTA CTGCAGATAC AACTACGGGG TTGTGGAGAG CTTCACAGTG 
CAGCGGCGAG TCCAACCTAA GGTGACTGTG TATCCTTCAA AGACCCAGCC CCTGCAGCAC 
CACAACCTCC TGGTCTGCTC TGTGAATGGT TTCTATCCAG GCAGCATTGA AGTCAGGTGG 
TTCCGGAACG GCCAGGAAGA GAAGGCTGGG GTGGTGTCCA CAGGCCTGAT CCAGAATGGA 
GACTGGACCT TCCAGACCCT GGTGATGCTG GAAACAGTTC CTCGGAGTGG AGAGGTTTAC 
ACCTGCCAAG TGGAGCATCC AAGCATGATG AGCCCTCTCA CGGTGCAATG GAGTGCACGG 
TCTGAATCTG CACAGAGCAA GATGCTGAGT GGAGTCGGGG GCTTTGTGCT GGGCCTGCTC 
TTCCTTGGGA CAGGGCTGTT CATCTACTTC AGGAATCAGA AAGGACACTC TGGACTTCAG 
CCAACAGGAC TCTTGAGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885779.1
CDS	68..868
Translation	MVCLKLPGGSCMAALTVTLTVLSSPLALAGDTQPRFLEQAKCECHFLNGTERVWNLIRYIYNQEEYARYNSDLGEYQAVTELGRPDAEYWNSQKDLLERRRAEVDTYCRYNYGVVESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVNGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSMMSPLTVQWSARSESAQSKMLSGVGGFVLGLLFLGTGLFIYFRNQKGHSGLQPTGLLS

Target ORF information:

RefSeq Version	XM_017030290.1
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017030290.1

ORF Insert Sequence:

ATGGTGTGTC TGAAGCTCCC TGGAGGCTCC TGTATGGCAG CGCTGACAGT GACATTGACG 
GTGCTGAGCT CCCCACTGGC TTTGGCTGGG GACACCCAAC CACGTTTCTT GGAGCAGGCT 
AAGTGTGAGT GTCATTTCCT CAATGGGACG GAGCGAGTGT GGAACCTGAT CAGATACATC 
TATAACCAAG AGGAGTACGC GCGCTACAAC AGTGACCTGG GGGAGTACCA GGCGGTGACG 
GAGCTGGGGC GGCCTGACGC TGAGTACTGG AACAGCCAGA AGGACCTCCT GGAGCGGAGG 
CGGGCCGAGG TGGACACCTA CTGCAGATAC AACTACGGGG TTGTGGAGAG CTTCACAGTG 
CAGCGGCGAG TCCAACCTAA GGTGACTGTG TATCCTTCAA AGACCCAGCC CCTGCAGCAC 
CACAACCTCC TGGTCTGCTC TGTGAATGGT TTCTATCCAG GCAGCATTGA AGTCAGGTGG 
TTCCGGAACG GCCAGGAAGA GAAGGCTGGG GTGGTGTCCA CAGGCCTGAT CCAGAATGGA 
GACTGGACCT TCCAGACCCT GGTGATGCTG GAAACAGTTC CTCGGAGTGG AGAGGTTTAC 
ACCTGCCAAG TGGAGCATCC AAGCATGATG AGCCCTCTCA CGGTGCAATG GAGTGCACGG 
TCTGAATCTG CACAGAGCAA GATGCTGAGT GGAGTCGGGG GCTTTGTGCT GGGCCTGCTC 
TTCCTTGGGA CAGGGCTGTT CATCTACTTC AGGAATCAGA AAGGACACTC TGGACTTCAG 
CCAACAGGAC TCTTGAGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HLA-DRB4 ( XM_011548127.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011546429.1 Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu58248
Clone ID Related Accession (Same CDS sequence)	XM_011548127.2
Accession Version	XM_011548127.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-12
Organism	Homo sapiens(human)
Product	major histocompatibility complex, class II, DR beta 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167247.2) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011548127.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END##

ATGTCAGACA AAAGGAGGTT TTTACTGAAA ATTTTGTGGG AGTCAAGGGA ATTCAAAGGG 
TCTCTCCTAG ACGATCCAGT GTTATGTCCT CCACAGGACC TTTGGTGTTG GCCCCTCTTC 
CTCATATGTG AGGATGGATC CAGTGGCCTC CCCATTATCT CCTTTCTTTT CTTTCTGAAC 
TCCAATGTTT ATAAAGCCTG TACCCCTGTT GCCTATGTAG GTTCTCTGAC AAAAGTTATA 
CTTAGTGCTC TTTCTTTCTT ATGGGGAAAA ATCCGTGGAA CTGAAGCTGA GATCTTTAGT 
ACGTGGAGTC ACCTTACAGA TATAGAGCAT TTATGCGGTA TTCATTGGTG CCTAAAGAAC 
TTTAGGCATC CTCTGGAAAA CCGGCCCAGA GGCAGCGCAG ACCAGGCACA AGCACGTTTC 
TTGGAGCAGG CTAAGTGTGA GTGTCATTTC CTCAATGGGA CGGAGCGAGT GTGGAACCTG 
ATCAGATACA TCTATAACCA AGAGGAGTAC GCGCGCTACA ACAGTGACCT GGGGGAGTAC 
CAGGCGGTGA CGGAGCTGGG GCGGCCTGAC GCTGAGTACT GGAACAGCCA GAAGGACCTC 
CTGGAGCGGA GGCGGGCCGA GGTGGACACC TACTGCAGAT ACAACTACGG GGTTGTGGAG 
AGCTTCACAG TGCAGCGGCG AGTCCAACCT AAGGTGACTG TGTATCCTTC AAAGACCCAG 
CCCCTGCAGC ACCACAACCT CCTGGTCTGC TCTGTGAATG GTTTCTATCC AGGCAGCATT 
GAAGTCAGGT GGTTCCGGAA CGGCCAGGAA GAGAAGGCTG GGGTGGTGTC CACAGGCCTG 
ATCCAGAATG GAGACTGGAC CTTCCAGACC CTGGTGATGC TGGAAACAGT TCCTCGGAGT 
GGAGAGGTTT ACACCTGCCA AGTGGAGCAT CCAAGCATGA TGAGCCCTCT CACGGTGCAA 
TGGAGTGCAC GGTCTGAATC TGCACAGAGC AAGATGCTGA GTGGAGTCGG GGGCTTTGTG 
CTGGGCCTGC TCTTCCTTGG GACAGGGCTG TTCATCTACT TCAGGAATCA GAAAGGACAC 
TCTGGACTTC AGCCAACAGG ACTCTTGAGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011546429.1
CDS	331..1443
Translation	MSDKRRFLLKILWESREFKGSLLDDPVLCPPQDLWCWPLFLICEDGSSGLPIISFLFFLNSNVYKACTPVAYVGSLTKVILSALSFLWGKIRGTEAEIFSTWSHLTDIEHLCGIHWCLKNFRHPLENRPRGSADQAQARFLEQAKCECHFLNGTERVWNLIRYIYNQEEYARYNSDLGEYQAVTELGRPDAEYWNSQKDLLERRRAEVDTYCRYNYGVVESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVNGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSMMSPLTVQWSARSESAQSKMLSGVGGFVLGLLFLGTGLFIYFRNQKGHSGLQPTGLLS

Target ORF information:

RefSeq Version	XM_011548127.2
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011548127.2

ORF Insert Sequence:

ATGTCAGACA AAAGGAGGTT TTTACTGAAA ATTTTGTGGG AGTCAAGGGA ATTCAAAGGG 
TCTCTCCTAG ACGATCCAGT GTTATGTCCT CCACAGGACC TTTGGTGTTG GCCCCTCTTC 
CTCATATGTG AGGATGGATC CAGTGGCCTC CCCATTATCT CCTTTCTTTT CTTTCTGAAC 
TCCAATGTTT ATAAAGCCTG TACCCCTGTT GCCTATGTAG GTTCTCTGAC AAAAGTTATA 
CTTAGTGCTC TTTCTTTCTT ATGGGGAAAA ATCCGTGGAA CTGAAGCTGA GATCTTTAGT 
ACGTGGAGTC ACCTTACAGA TATAGAGCAT TTATGCGGTA TTCATTGGTG CCTAAAGAAC 
TTTAGGCATC CTCTGGAAAA CCGGCCCAGA GGCAGCGCAG ACCAGGCACA AGCACGTTTC 
TTGGAGCAGG CTAAGTGTGA GTGTCATTTC CTCAATGGGA CGGAGCGAGT GTGGAACCTG 
ATCAGATACA TCTATAACCA AGAGGAGTAC GCGCGCTACA ACAGTGACCT GGGGGAGTAC 
CAGGCGGTGA CGGAGCTGGG GCGGCCTGAC GCTGAGTACT GGAACAGCCA GAAGGACCTC 
CTGGAGCGGA GGCGGGCCGA GGTGGACACC TACTGCAGAT ACAACTACGG GGTTGTGGAG 
AGCTTCACAG TGCAGCGGCG AGTCCAACCT AAGGTGACTG TGTATCCTTC AAAGACCCAG 
CCCCTGCAGC ACCACAACCT CCTGGTCTGC TCTGTGAATG GTTTCTATCC AGGCAGCATT 
GAAGTCAGGT GGTTCCGGAA CGGCCAGGAA GAGAAGGCTG GGGTGGTGTC CACAGGCCTG 
ATCCAGAATG GAGACTGGAC CTTCCAGACC CTGGTGATGC TGGAAACAGT TCCTCGGAGT 
GGAGAGGTTT ACACCTGCCA AGTGGAGCAT CCAAGCATGA TGAGCCCTCT CACGGTGCAA 
TGGAGTGCAC GGTCTGAATC TGCACAGAGC AAGATGCTGA GTGGAGTCGG GGGCTTTGTG 
CTGGGCCTGC TCTTCCTTGG GACAGGGCTG TTCATCTACT TCAGGAATCA GAAAGGACAC 
TCTGGACTTC AGCCAACAGG ACTCTTGAGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HLA-DRB4 ( XM_011548128.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011546430.1 Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu58249
Clone ID Related Accession (Same CDS sequence)	XM_011548128.2
Accession Version	XM_011548128.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-12
Organism	Homo sapiens(human)
Product	major histocompatibility complex, class II, DR beta 4 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167247.2) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011548128.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END##

ATGTCAGACA AAAGGAGGTT TTTACTGAAA ATTTTGTGGG AGTCAAGGGA ATTCAAAGGG 
TCTCTCCTAG ACGATCCAGT GTTATGTCCT CCACAGGACC TTTGGTGTTG GCCCCTCTTC 
CTCATATGTG AGGATGGATC CAGTGGCCTC CCCATTATCT CCTTTCTTTT CTTTCTGAAC 
TCCAATGTTT ATAAAGCCTG TACCCCTGTT GCCTATGTAG GTTCTCTGAC AAAAGTTATA 
CTTAGTGCTC TTTCTTTCTT ATGGGGAAAA ATCCGTGGAA CTGAAGCTGA GATCTTTAGT 
ACGTGGAGTC ACCTTACAGA TATAGAGCAT TTATGCGGTA TTCATTGGTG CCTAAAGAAC 
TTTAGGCATC CTCTGGAAAA CCGGCCCAGA GGCAGCGCAG ACCAGGCACA AGCACGTTTC 
TTGGAGCAGG CTAAGTGTGA GTGTCATTTC CTCAATGGGA CGGAGCGAGT GTGGAACCTG 
ATCAGATACA TCTATAACCA AGAGGAGTAC GCGCGCTACA ACAGTGACCT GGGGGAGTAC 
CAGGCGGTGA CGGAGCTGGG GCGGCCTGAC GCTGAGTACT GGAACAGCCA GAAGGACCTC 
CTGGAGCGGA GGCGGGCCGA GGTGGACACC TACTGCAGAT ACAACTACGG GGTTGTGGAG 
AGCTTCACAG TGCAGCGGCG AGGTGAGCCT AAGGTGACTG TGTATCCTTC AAAGACCCAG 
CCCCTGCAGC ACCACAACCT CCTGGTCTGC TCTGTGAATG GTTTCTATCC AGGCAGCATT 
GAAGTCAGGT GGTTCCGGAA CGGCCAGGAA GAGAAGGCTG GGGTGGTGTC CACAGGCCTG 
ATCCAGAATG GAGACTGGAC CTTCCAGACC CTGGTGATGC TGGAAACAGT TCCTCGGAGT 
GGAGAGGTTT ACACCTGCCA AGTGGAGCAT CCAAGCATGA TGAGCCCTCT CACGGTGCAA 
TGGAGTGCAC GGTCTGAATC TGCACAGAGC AAGATGCTGA GTGGAGTCGG GGGCTTTGTG 
CTGGGCCTGC TCTTCCTTGG GACAGGGCTG TTCATCTACT TCAGGAATCA GAAAGGACAC 
TCTGGACTTC AGCCAACAGG ACTCTTGAGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011546430.1
CDS	332..1444
Translation	MSDKRRFLLKILWESREFKGSLLDDPVLCPPQDLWCWPLFLICEDGSSGLPIISFLFFLNSNVYKACTPVAYVGSLTKVILSALSFLWGKIRGTEAEIFSTWSHLTDIEHLCGIHWCLKNFRHPLENRPRGSADQAQARFLEQAKCECHFLNGTERVWNLIRYIYNQEEYARYNSDLGEYQAVTELGRPDAEYWNSQKDLLERRRAEVDTYCRYNYGVVESFTVQRRGEPKVTVYPSKTQPLQHHNLLVCSVNGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSMMSPLTVQWSARSESAQSKMLSGVGGFVLGLLFLGTGLFIYFRNQKGHSGLQPTGLLS

Target ORF information:

RefSeq Version	XM_011548128.2
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011548128.2

ORF Insert Sequence:

ATGTCAGACA AAAGGAGGTT TTTACTGAAA ATTTTGTGGG AGTCAAGGGA ATTCAAAGGG 
TCTCTCCTAG ACGATCCAGT GTTATGTCCT CCACAGGACC TTTGGTGTTG GCCCCTCTTC 
CTCATATGTG AGGATGGATC CAGTGGCCTC CCCATTATCT CCTTTCTTTT CTTTCTGAAC 
TCCAATGTTT ATAAAGCCTG TACCCCTGTT GCCTATGTAG GTTCTCTGAC AAAAGTTATA 
CTTAGTGCTC TTTCTTTCTT ATGGGGAAAA ATCCGTGGAA CTGAAGCTGA GATCTTTAGT 
ACGTGGAGTC ACCTTACAGA TATAGAGCAT TTATGCGGTA TTCATTGGTG CCTAAAGAAC 
TTTAGGCATC CTCTGGAAAA CCGGCCCAGA GGCAGCGCAG ACCAGGCACA AGCACGTTTC 
TTGGAGCAGG CTAAGTGTGA GTGTCATTTC CTCAATGGGA CGGAGCGAGT GTGGAACCTG 
ATCAGATACA TCTATAACCA AGAGGAGTAC GCGCGCTACA ACAGTGACCT GGGGGAGTAC 
CAGGCGGTGA CGGAGCTGGG GCGGCCTGAC GCTGAGTACT GGAACAGCCA GAAGGACCTC 
CTGGAGCGGA GGCGGGCCGA GGTGGACACC TACTGCAGAT ACAACTACGG GGTTGTGGAG 
AGCTTCACAG TGCAGCGGCG AGGTGAGCCT AAGGTGACTG TGTATCCTTC AAAGACCCAG 
CCCCTGCAGC ACCACAACCT CCTGGTCTGC TCTGTGAATG GTTTCTATCC AGGCAGCATT 
GAAGTCAGGT GGTTCCGGAA CGGCCAGGAA GAGAAGGCTG GGGTGGTGTC CACAGGCCTG 
ATCCAGAATG GAGACTGGAC CTTCCAGACC CTGGTGATGC TGGAAACAGT TCCTCGGAGT 
GGAGAGGTTT ACACCTGCCA AGTGGAGCAT CCAAGCATGA TGAGCCCTCT CACGGTGCAA 
TGGAGTGCAC GGTCTGAATC TGCACAGAGC AAGATGCTGA GTGGAGTCGG GGGCTTTGTG 
CTGGGCCTGC TCTTCCTTGG GACAGGGCTG TTCATCTACT TCAGGAATCA GAAAGGACAC 
TCTGGACTTC AGCCAACAGG ACTCTTGAGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HLA-DRB4 ( XM_011548129.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011546431.1 Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu58250
Clone ID Related Accession (Same CDS sequence)	XM_011548129.2
Accession Version	XM_011548129.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-12
Organism	Homo sapiens(human)
Product	major histocompatibility complex, class II, DR beta 4 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167247.2) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011548129.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END##

ATGTCAGACA AAAGGAGGTT TTTACTGAAA ATTTTGTGGG AGTCAAGGGA ATTCAAAGGG 
TCTCTCCTAG ACGATCCAGT GTTATGTCCT CCACAGGACC TTTGGTGTTG GCCCCTCTTC 
CTCATATGTG AGGATGGATC CAGTGGCCTC CCCATTATCT CCTTTCTTTT CTTTCTGAAC 
TCCAATGTTT ATAAAGCCTG TACCCCTGTT GCCTATGTAG GTTCTCTGAC AAAAGTTATA 
CTTAGTGCTC TTTCTTTCTT ATGGGGAAAA ATCCGTGGAA CTGAAGCTGA GATCTTTAGT 
ACGTGGAGTC ACCTTACAGA TATAGAGCAT TTATGCGGTA TTCATTGGTG CCTAAAGAAC 
TTTAGGCATC CTCTGGAAAA CCGGCCCAGA GGCAGCGCAG ACCAGGCACA AGCACGTTTC 
TTGGAGCAGG CTAAGTGTGA GTGTCATTTC CTCAATGGGA CGGAGCGAGT GTGGAACCTG 
ATCAGATACA TCTATAACCA AGAGGAGTAC GCGCGCTACA ACAGTGACCT GGGGGAGTAC 
CAGGCGGTGA CGGAGCTGGG GCGGCCTGAC GCTGAGTACT GGAACAGCCA GAAGGACCTC 
CTGGAGCGGA GGCGGGCCGA GGTGGACACC TACTGCAGAT ACAACTACGG GGTTGTGGAG 
AGCTTCACAG TGCAGCGGCG AGGTGCACGG TCTGAATCTG CACAGAGCAA GATGCTGAGT 
GGAGTCGGGG GCTTTGTGCT GGGCCTGCTC TTCCTTGGGA CAGGGCTGTT CATCTACTTC 
AGGAATCAGA AAGGACACTC TGGACTTCAG CCAACAGGAC TCTTGAGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011546431.1
CDS	338..1168
Translation	MSDKRRFLLKILWESREFKGSLLDDPVLCPPQDLWCWPLFLICEDGSSGLPIISFLFFLNSNVYKACTPVAYVGSLTKVILSALSFLWGKIRGTEAEIFSTWSHLTDIEHLCGIHWCLKNFRHPLENRPRGSADQAQARFLEQAKCECHFLNGTERVWNLIRYIYNQEEYARYNSDLGEYQAVTELGRPDAEYWNSQKDLLERRRAEVDTYCRYNYGVVESFTVQRRGARSESAQSKMLSGVGGFVLGLLFLGTGLFIYFRNQKGHSGLQPTGLLS

Target ORF information:

RefSeq Version	XM_011548129.2
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011548129.2

ORF Insert Sequence:

ATGTCAGACA AAAGGAGGTT TTTACTGAAA ATTTTGTGGG AGTCAAGGGA ATTCAAAGGG 
TCTCTCCTAG ACGATCCAGT GTTATGTCCT CCACAGGACC TTTGGTGTTG GCCCCTCTTC 
CTCATATGTG AGGATGGATC CAGTGGCCTC CCCATTATCT CCTTTCTTTT CTTTCTGAAC 
TCCAATGTTT ATAAAGCCTG TACCCCTGTT GCCTATGTAG GTTCTCTGAC AAAAGTTATA 
CTTAGTGCTC TTTCTTTCTT ATGGGGAAAA ATCCGTGGAA CTGAAGCTGA GATCTTTAGT 
ACGTGGAGTC ACCTTACAGA TATAGAGCAT TTATGCGGTA TTCATTGGTG CCTAAAGAAC 
TTTAGGCATC CTCTGGAAAA CCGGCCCAGA GGCAGCGCAG ACCAGGCACA AGCACGTTTC 
TTGGAGCAGG CTAAGTGTGA GTGTCATTTC CTCAATGGGA CGGAGCGAGT GTGGAACCTG 
ATCAGATACA TCTATAACCA AGAGGAGTAC GCGCGCTACA ACAGTGACCT GGGGGAGTAC 
CAGGCGGTGA CGGAGCTGGG GCGGCCTGAC GCTGAGTACT GGAACAGCCA GAAGGACCTC 
CTGGAGCGGA GGCGGGCCGA GGTGGACACC TACTGCAGAT ACAACTACGG GGTTGTGGAG 
AGCTTCACAG TGCAGCGGCG AGGTGCACGG TCTGAATCTG CACAGAGCAA GATGCTGAGT 
GGAGTCGGGG GCTTTGTGCT GGGCCTGCTC TTCCTTGGGA CAGGGCTGTT CATCTACTTC 
AGGAATCAGA AAGGACACTC TGGACTTCAG CCAACAGGAC TCTTGAGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HLA-DRB4 ( XM_024452550.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024308318.1 Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X7, mRNA.

Price & Availability↑

CloneID	OHu58247
Clone ID Related Accession (Same CDS sequence)	XM_024452550.1
Accession Version	XM_024452550.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-12
Organism	Homo sapiens(human)
Product	major histocompatibility complex, class II, DR beta 4 isoform X6
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167247.2) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END##

ATGGTGTGTC TGAAGCTCCC TGGAGGCTCC TGTATGGCAG CGCTGACAGT GACATTGACG 
GTGCTGAGCT CCCCACTGGC TTTGGCTGGG GACACCCAAC CACGTTTCTT GGAGCAGGCT 
AAGTGTGAGT GTCATTTCCT CAATGGGACG GAGCGAGTGT GGAACCTGAT CAGATACATC 
TATAACCAAG AGGAGTACGC GCGCTACAAC AGTGACCTGG GGGAGTACCA GGCGGTGACG 
GAGCTGGGGC GGCCTGACGC TGAGTACTGG AACAGCCAGA AGGACCTCCT GGAGCGGAGG 
CGGGCCGAGG TGGACACCTA CTGCAGATAC AACTACGGGG TTGTGGAGAG CTTCACAGTG 
CAGCGGCGAG GTGCACGGTC TGAATCTGCA CAGAGCAAGA TGCTGAGTGG AGTCGGGGGC 
TTTGTGCTGG GCCTGCTCTT CCTTGGGACA GGGCTGTTCA TCTACTTCAG GAATCAGAAA 
GGACACTCTG GACTTCAGCC AACAGGACTC TTGAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024308318.1
CDS	102..620
Translation	MVCLKLPGGSCMAALTVTLTVLSSPLALAGDTQPRFLEQAKCECHFLNGTERVWNLIRYIYNQEEYARYNSDLGEYQAVTELGRPDAEYWNSQKDLLERRRAEVDTYCRYNYGVVESFTVQRRGARSESAQSKMLSGVGGFVLGLLFLGTGLFIYFRNQKGHSGLQPTGLLS

Target ORF information:

RefSeq Version	XM_024452550.1
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X7, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024452550.1

ORF Insert Sequence:

ATGGTGTGTC TGAAGCTCCC TGGAGGCTCC TGTATGGCAG CGCTGACAGT GACATTGACG 
GTGCTGAGCT CCCCACTGGC TTTGGCTGGG GACACCCAAC CACGTTTCTT GGAGCAGGCT 
AAGTGTGAGT GTCATTTCCT CAATGGGACG GAGCGAGTGT GGAACCTGAT CAGATACATC 
TATAACCAAG AGGAGTACGC GCGCTACAAC AGTGACCTGG GGGAGTACCA GGCGGTGACG 
GAGCTGGGGC GGCCTGACGC TGAGTACTGG AACAGCCAGA AGGACCTCCT GGAGCGGAGG 
CGGGCCGAGG TGGACACCTA CTGCAGATAC AACTACGGGG TTGTGGAGAG CTTCACAGTG 
CAGCGGCGAG GTGCACGGTC TGAATCTGCA CAGAGCAAGA TGCTGAGTGG AGTCGGGGGC 
TTTGTGCTGG GCCTGCTCTT CCTTGGGACA GGGCTGTTCA TCTACTTCAG GAATCAGAAA 
GGACACTCTG GACTTCAGCC AACAGGACTC TTGAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HLA-DRB4 ( XM_017030291.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885780.1 Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X6, mRNA.

Price & Availability↑

CloneID	OHu99647
Clone ID Related Accession (Same CDS sequence)	XM_017030291.1
Accession Version	XM_017030291.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-12
Organism	Homo sapiens(human)
Product	major histocompatibility complex, class II, DR beta 4 isoform X5
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167247.2) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END##

ATGTCAGACA AAAGGAGGTT TTTACTGAAA ATTTTGTGGG AGTCAAGGGA ATTCAAAGGG 
TCTCTCCTAG ACGATCCAGT GTTATGTCCT CCACAGGACC TTTGGTGTTG GCCCCTCTTC 
CTCATATGTG AGGATGGATC CAGTGGCCTC CCCATTATCT CCTTTCTTTT CTTTCTGAAC 
TCCAATGTTT ATAAAGCCTG TACCCCTGTT GCCTATGTAG GTTCTCTGAC AAAAGTTATA 
CTTAGTGCTC TTTCTTTCTT ATGGGGAAAA ATCCGTGGAA CTGAAGCTGA GATCTTTAGT 
ACGTGGAGTC ACCTTACAGA TATAGAGCAT TTATGCGGTA TTCATTGGTG CCTAAAGAAC 
TTTAGGCATC CTCTGGAAAA CCGGCCCAGA GGCAGCGCAG ACCAGGCACA AGCACGTTTC 
TTGGAGCAGG CTAAGTGTGA GTGTCATTTC CTCAATGGGA CGGAGCGAGT GTGGAACCTG 
ATCAGATACA TCTATAACCA AGAGGAGTAC GCGCGCTACA ACAGTGACCT GGGGGAGTAC 
CAGGCGGTGA CGGAGCTGGG GCGGCCTGAC GCTGAGTACT GGAACAGCCA GAAGGACCTC 
CTGGAGCGGA GGCGGGCCGA GGTGGACACC TACTGCAGAT ACAACTACGG GGTTGTGGAG 
AGCTTCACAG TGCAGCGGCG AGGTGACAAA GTTGAGACAC AGAAGAATCA AAAAACTCTT 
CCAGCATCAA CCAGTAAAAG GCAGACCTTG GATTTCAACC AGGCAACATG GCTCAGATAT 
CAGTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885780.1
CDS	338..1126
Translation	MSDKRRFLLKILWESREFKGSLLDDPVLCPPQDLWCWPLFLICEDGSSGLPIISFLFFLNSNVYKACTPVAYVGSLTKVILSALSFLWGKIRGTEAEIFSTWSHLTDIEHLCGIHWCLKNFRHPLENRPRGSADQAQARFLEQAKCECHFLNGTERVWNLIRYIYNQEEYARYNSDLGEYQAVTELGRPDAEYWNSQKDLLERRRAEVDTYCRYNYGVVESFTVQRRGDKVETQKNQKTLPASTSKRQTLDFNQATWLRYQF

Target ORF information:

RefSeq Version	XM_017030291.1
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), transcript variant X6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017030291.1

ORF Insert Sequence:

ATGTCAGACA AAAGGAGGTT TTTACTGAAA ATTTTGTGGG AGTCAAGGGA ATTCAAAGGG 
TCTCTCCTAG ACGATCCAGT GTTATGTCCT CCACAGGACC TTTGGTGTTG GCCCCTCTTC 
CTCATATGTG AGGATGGATC CAGTGGCCTC CCCATTATCT CCTTTCTTTT CTTTCTGAAC 
TCCAATGTTT ATAAAGCCTG TACCCCTGTT GCCTATGTAG GTTCTCTGAC AAAAGTTATA 
CTTAGTGCTC TTTCTTTCTT ATGGGGAAAA ATCCGTGGAA CTGAAGCTGA GATCTTTAGT 
ACGTGGAGTC ACCTTACAGA TATAGAGCAT TTATGCGGTA TTCATTGGTG CCTAAAGAAC 
TTTAGGCATC CTCTGGAAAA CCGGCCCAGA GGCAGCGCAG ACCAGGCACA AGCACGTTTC 
TTGGAGCAGG CTAAGTGTGA GTGTCATTTC CTCAATGGGA CGGAGCGAGT GTGGAACCTG 
ATCAGATACA TCTATAACCA AGAGGAGTAC GCGCGCTACA ACAGTGACCT GGGGGAGTAC 
CAGGCGGTGA CGGAGCTGGG GCGGCCTGAC GCTGAGTACT GGAACAGCCA GAAGGACCTC 
CTGGAGCGGA GGCGGGCCGA GGTGGACACC TACTGCAGAT ACAACTACGG GGTTGTGGAG 
AGCTTCACAG TGCAGCGGCG AGGTGACAAA GTTGAGACAC AGAAGAATCA AAAAACTCTT 
CCAGCATCAA CCAGTAAAAG GCAGACCTTG GATTTCAACC AGGCAACATG GCTCAGATAT 
CAGTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A humanized HLA-DR4 mouse model for autoimmune myocarditis.
Journal of molecular and cellular cardiology10722-26(2017 Jun)
?elli ME,Thomas AC,Wraith DC,Newby AC

Anti-LGI1 encephalitis is strongly associated with HLA-DR7 and HLA-DRB4.
Annals of neurology81(2)193-198(2017 Feb)
van Sonderen A,Roelen DL,Stoop JA,Verdijk RM,Haasnoot GW,Thijs RD,Wirtz PW,Schreurs MW,Claas FH,Sillevis Smitt PA,Titulaer MJ

The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model.
Clinical and experimental immunology186(2)164-176(2016 Nov)
Yuksel M,Xiao X,Tai N,Vijay GM,G?lden E,Beland K,Lapierre P,Alvarez F,Hu Z,Colle I,Ma Y,Wen L

Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes.
Diabetes65(3)710-8(2016 Mar)
Zhao LP,Alshiekh S,Zhao M,Carlsson A,Larsson HE,Forsander G,Ivarsson SA,Ludvigsson J,Kockum I,Marcus C,Persson M,Samuelsson U,?rtqvist E,Pyo CW,Nelson WC,Geraghty DE,Lernmark ?,

HLA-DR4-associated T and B cell responses to specific determinants on the IA-2 autoantigen in type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950)193(9)4448-56(2014 Nov)
McLaughlin KA,Gulati K,Richardson CC,Morgan D,Bodansky HJ,Feltbower RG,Christie MR

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HLA-DRB4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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