HLA-DPA1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HLA-DPA1
Entrez Gene ID	3113
Full Name	major histocompatibility complex, class II, DP alpha 1
Synonyms	DP(W3),DP(W4),HLA-DP1A,HLADP,HLASB,PLT1
General protein information	Preferred Names major histocompatibility complex, class II, DP alpha 1 Names HLA class II histocompatibility antigen, DP alpha 1 chain HLA DPA1 HLA-SB alpha chain MHC class II DP3-alpha MHC class II HLA-DPA1 antigen
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.32
Summary	HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008].
Disorder MIM:	142880

mRNA and Protein(s)

mRNA	Protein	Name
NM_001242524.2	NP_001229453.1	HLA class II histocompatibility antigen, DP alpha 1 chain precursor
NM_001242524.1	NP_001229453.1	HLA class II histocompatibility antigen, DP alpha 1 chain precursor
NM_033554.3	NP_291032.2	HLA class II histocompatibility antigen, DP alpha 1 chain precursor
NM_001242525.2	NP_001229454.1	HLA class II histocompatibility antigen, DP alpha 1 chain precursor
NM_001242525.1	NP_001229454.1	HLA class II histocompatibility antigen, DP alpha 1 chain precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	HLA-DPA1	NP_001229453.1
	MAMU-DPA	NP_001041712.1
Danio rerio (zebrafish)	LOC795595	XP_005165043.1
Danio rerio (zebrafish)	LOC100332204	XP_002660434.3
Danio rerio (zebrafish)	zgc:123107	NP_001032481.2
Danio rerio (zebrafish)	LOC571282	XP_699949.2
Pan troglodytes (chimpanzee)	PATR-DPA1	XP_518390.2
Danio rerio (zebrafish)	si:busm1-194e12.8	XP_005167290.1
Danio rerio (zebrafish)	si:busm1-48c11.3	NP_001007206.1
Danio rerio (zebrafish)	zgc:103599	NP_001005975.1
Danio rerio (zebrafish)	LOC100332267	XP_002660435.3
Danio rerio (zebrafish)	si:busm1-266f07.2	NP_001004521.2
Danio rerio (zebrafish)	si:busm1-160c18.6	NP_001007049.2

Gene Ontology
Bibliography

Related articles in PubMed

Genetic Polymorphism and Decreased Expression of HLA class II DP Genes are Associated with HBV Reactivation in Patients Treated with Immunomodulatory Agents.
Matsuda H, Hiramatsu K, Akazawa Y, Nosaka T, Saito Y, Ozaki Y, Hayama R, Takahashi K, Naito T, Ofuji K, Ohtani M, Nemoto T, Hida Y, Kimura H, Soya Y, Nakamoto Y
Journal of medical virology(2017 Dec)

Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features.
Takejima P, Agondi RC, Rodrigues H, Aun MV, Kalil J, Giavina-Bianchi P
International archives of allergy and immunology172(3)150-160(2017)

Genetic risk factors for sclerotic graft-versus-host disease.
Inamoto Y, Martin PJ, Flowers ME, Lee SJ, Carpenter PA, Warren EH, Geraghty DE, Lee N, Boeckh MJ, Storer BE, Levine DM, Fan W, Zhao LP, Hansen JA
Blood128(11)1516-24(2016 09)

Protective effects of HLA-DPA1/DPB1 variants against Hepatitis B virus infection in an Indonesian population.
Wasityastuti W, Yano Y, Ratnasari N, Triyono T, Triwikatmani C, Indrarti F, Heriyanto DS, Yamani LN, Liang Y, Utsumi T, Hayashi Y
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases41177-184(2016 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The HLA-B*42, HLA-C*17, HLA-DPA1*03, and HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 genotype with the nonallergic phenotype. The presence of the haplotype HLA-DPA1*03 DQA*05 was associated with allergic asthma, and the presence of HLA-DPA1*03 and the absence of HLA-DQA*05 with nonallergic asthma.
Title: Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features.

Single-nucleotide polymorphism in HLA-DPA1 gene is associated with sclerotic graft-versus-host disease.
Title: Genetic risk factors for sclerotic graft-versus-host disease.

HLA-DPA1 and HLA-DPB1 variants can determine susceptibility or protective effect against Hepatitis B virus infection in an Indonesian population.
Title: Protective effects of HLA-DPA1/DPB1 variants against Hepatitis B virus infection in an Indonesian population.

Single-nucleotide polymorphism in HLA-DP is associated with cervical cancer susceptibility.
Title: HLA-DP is the cervical cancer susceptibility loci among women infected by high-risk human papillomavirus: potential implication for triage of human papillomavirus-positive women.

DPA1*02:01- DPB1*14:01 and DPA1*02:01- DPB1*17:01 haplotypes provide considerable protection effect against Posner-Schlossman syndrome.
Title: [Association of HLA-DPA1 and -DPB1 polymorphisms with Posner-Schlossman syndrome among southern Chinese Han population].

The following HLA-DPA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HLA-DPA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21315	NM_033554.3 Latest version!	Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu21315	NM_001242525.2 Latest version!	Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu21315	NM_001242524.2 Latest version!	Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu21315	NM_001242524.1	Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu21315	NM_001242525.1	Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HLA-DPA1 ( NM_001242524.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001229453.1 Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21315
Clone ID Related Accession (Same CDS sequence)	NM_001242524.2 , NM_001242524.1 , NM_033554.3 , NM_001242525.2 , NM_001242525.1
Accession Version	NM_001242524.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-03
Organism	Homo sapiens(human)
Product	HLA class II histocompatibility antigen, DP alpha 1 chain precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI553587.1, CD516536.1, X00457.1, AL645931.7 and BU687966.1. On Jun 2, 2019 this sequence version replaced NM_001242524.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: SRR1163658.310161.1, SRR1163657.192141.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCCCTG AAGACAGAAT GTTCCATATC AGAGCTGTGA TCTTGAGAGC CCTCTCCTTG 
GCTTTCCTGC TGAGTCTCCG AGGAGCTGGG GCCATCAAGG CGGACCATGT GTCAACTTAT 
GCCGCGTTTG TACAGACGCA TAGACCAACA GGGGAGTTTA TGTTTGAATT TGATGAAGAT 
GAGATGTTCT ATGTGGATCT GGACAAGAAG GAGACCGTCT GGCATCTGGA GGAGTTTGGC 
CAAGCCTTTT CCTTTGAGGC TCAGGGCGGG CTGGCTAACA TTGCTATATT GAACAACAAC 
TTGAATACCT TGATCCAGCG TTCCAACCAC ACTCAGGCCA CCAACGATCC CCCTGAGGTG 
ACCGTGTTTC CCAAGGAGCC TGTGGAGCTG GGCCAGCCCA ACACCCTCAT CTGCCACATT 
GACAAGTTCT TCCCACCAGT GCTCAACGTC ACGTGGCTGT GCAACGGGGA GCTGGTCACT 
GAGGGTGTCG CTGAGAGCCT CTTCCTGCCC AGAACAGATT ACAGCTTCCA CAAGTTCCAT 
TACCTGACCT TTGTGCCCTC AGCAGAGGAC TTCTATGACT GCAGGGTGGA GCACTGGGGC 
TTGGACCAGC CGCTCCTCAA GCACTGGGAG GCCCAAGAGC CAATCCAGAT GCCTGAGACA 
ACGGAGACTG TGCTCTGTGC CCTGGGCCTG GTGCTGGGCC TAGTCGGCAT CATCGTGGGC 
ACCGTCCTCA TCATAAAGTC TCTGCGTTCT GGCCATGACC CCCGGGCCCA GGGGACCCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001229453.1
CDS	169..951
Translation	MRPEDRMFHIRAVILRALSLAFLLSLRGAGAIKADHVSTYAAFVQTHRPTGEFMFEFDEDEMFYVDLDKKETVWHLEEFGQAFSFEAQGGLANIAILNNNLNTLIQRSNHTQATNDPPEVTVFPKEPVELGQPNTLICHIDKFFPPVLNVTWLCNGELVTEGVAESLFLPRTDYSFHKFHYLTFVPSAEDFYDCRVEHWGLDQPLLKHWEAQEPIQMPETTETVLCALGLVLGLVGIIVGTVLIIKSLRSGHDPRAQGTL

Target ORF information:

RefSeq Version	NM_001242524.2
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001242524.2

ORF Insert Sequence:

ATGCGCCCTG AAGACAGAAT GTTCCATATC AGAGCTGTGA TCTTGAGAGC CCTCTCCTTG 
GCTTTCCTGC TGAGTCTCCG AGGAGCTGGG GCCATCAAGG CGGACCATGT GTCAACTTAT 
GCCGCGTTTG TACAGACGCA TAGACCAACA GGGGAGTTTA TGTTTGAATT TGATGAAGAT 
GAGATGTTCT ATGTGGATCT GGACAAGAAG GAGACCGTCT GGCATCTGGA GGAGTTTGGC 
CAAGCCTTTT CCTTTGAGGC TCAGGGCGGG CTGGCTAACA TTGCTATATT GAACAACAAC 
TTGAATACCT TGATCCAGCG TTCCAACCAC ACTCAGGCCA CCAACGATCC CCCTGAGGTG 
ACCGTGTTTC CCAAGGAGCC TGTGGAGCTG GGCCAGCCCA ACACCCTCAT CTGCCACATT 
GACAAGTTCT TCCCACCAGT GCTCAACGTC ACGTGGCTGT GCAACGGGGA GCTGGTCACT 
GAGGGTGTCG CTGAGAGCCT CTTCCTGCCC AGAACAGATT ACAGCTTCCA CAAGTTCCAT 
TACCTGACCT TTGTGCCCTC AGCAGAGGAC TTCTATGACT GCAGGGTGGA GCACTGGGGC 
TTGGACCAGC CGCTCCTCAA GCACTGGGAG GCCCAAGAGC CAATCCAGAT GCCTGAGACA 
ACGGAGACTG TGCTCTGTGC CCTGGGCCTG GTGCTGGGCC TAGTCGGCAT CATCGTGGGC 
ACCGTCCTCA TCATAAAGTC TCTGCGTTCT GGCCATGACC CCCGGGCCCA GGGGACCCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HLA-DPA1 ( NM_001242524.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001229453.1 Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21315
Clone ID Related Accession (Same CDS sequence)	NM_001242524.2 , NM_001242524.1 , NM_033554.3 , NM_001242525.2 , NM_001242525.1
Accession Version	NM_001242524.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	HLA class II histocompatibility antigen, DP alpha 1 chain precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI553587.1, CD516536.1, X00457.1, AL645931.7 and BU687966.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: SRR1163655.92892.1, SRR1163658.362118.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCCCTG AAGACAGAAT GTTCCATATC AGAGCTGTGA TCTTGAGAGC CCTCTCCTTG 
GCTTTCCTGC TGAGTCTCCG AGGAGCTGGG GCCATCAAGG CGGACCATGT GTCAACTTAT 
GCCGCGTTTG TACAGACGCA TAGACCAACA GGGGAGTTTA TGTTTGAATT TGATGAAGAT 
GAGATGTTCT ATGTGGATCT GGACAAGAAG GAGACCGTCT GGCATCTGGA GGAGTTTGGC 
CAAGCCTTTT CCTTTGAGGC TCAGGGCGGG CTGGCTAACA TTGCTATATT GAACAACAAC 
TTGAATACCT TGATCCAGCG TTCCAACCAC ACTCAGGCCA CCAACGATCC CCCTGAGGTG 
ACCGTGTTTC CCAAGGAGCC TGTGGAGCTG GGCCAGCCCA ACACCCTCAT CTGCCACATT 
GACAAGTTCT TCCCACCAGT GCTCAACGTC ACGTGGCTGT GCAACGGGGA GCTGGTCACT 
GAGGGTGTCG CTGAGAGCCT CTTCCTGCCC AGAACAGATT ACAGCTTCCA CAAGTTCCAT 
TACCTGACCT TTGTGCCCTC AGCAGAGGAC TTCTATGACT GCAGGGTGGA GCACTGGGGC 
TTGGACCAGC CGCTCCTCAA GCACTGGGAG GCCCAAGAGC CAATCCAGAT GCCTGAGACA 
ACGGAGACTG TGCTCTGTGC CCTGGGCCTG GTGCTGGGCC TAGTCGGCAT CATCGTGGGC 
ACCGTCCTCA TCATAAAGTC TCTGCGTTCT GGCCATGACC CCCGGGCCCA GGGGACCCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001229453.1
CDS	199..981
Translation	MRPEDRMFHIRAVILRALSLAFLLSLRGAGAIKADHVSTYAAFVQTHRPTGEFMFEFDEDEMFYVDLDKKETVWHLEEFGQAFSFEAQGGLANIAILNNNLNTLIQRSNHTQATNDPPEVTVFPKEPVELGQPNTLICHIDKFFPPVLNVTWLCNGELVTEGVAESLFLPRTDYSFHKFHYLTFVPSAEDFYDCRVEHWGLDQPLLKHWEAQEPIQMPETTETVLCALGLVLGLVGIIVGTVLIIKSLRSGHDPRAQGTL

Target ORF information:

RefSeq Version	NM_001242524.1
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001242524.1

ORF Insert Sequence:

ATGCGCCCTG AAGACAGAAT GTTCCATATC AGAGCTGTGA TCTTGAGAGC CCTCTCCTTG 
GCTTTCCTGC TGAGTCTCCG AGGAGCTGGG GCCATCAAGG CGGACCATGT GTCAACTTAT 
GCCGCGTTTG TACAGACGCA TAGACCAACA GGGGAGTTTA TGTTTGAATT TGATGAAGAT 
GAGATGTTCT ATGTGGATCT GGACAAGAAG GAGACCGTCT GGCATCTGGA GGAGTTTGGC 
CAAGCCTTTT CCTTTGAGGC TCAGGGCGGG CTGGCTAACA TTGCTATATT GAACAACAAC 
TTGAATACCT TGATCCAGCG TTCCAACCAC ACTCAGGCCA CCAACGATCC CCCTGAGGTG 
ACCGTGTTTC CCAAGGAGCC TGTGGAGCTG GGCCAGCCCA ACACCCTCAT CTGCCACATT 
GACAAGTTCT TCCCACCAGT GCTCAACGTC ACGTGGCTGT GCAACGGGGA GCTGGTCACT 
GAGGGTGTCG CTGAGAGCCT CTTCCTGCCC AGAACAGATT ACAGCTTCCA CAAGTTCCAT 
TACCTGACCT TTGTGCCCTC AGCAGAGGAC TTCTATGACT GCAGGGTGGA GCACTGGGGC 
TTGGACCAGC CGCTCCTCAA GCACTGGGAG GCCCAAGAGC CAATCCAGAT GCCTGAGACA 
ACGGAGACTG TGCTCTGTGC CCTGGGCCTG GTGCTGGGCC TAGTCGGCAT CATCGTGGGC 
ACCGTCCTCA TCATAAAGTC TCTGCGTTCT GGCCATGACC CCCGGGCCCA GGGGACCCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HLA-DPA1 ( NM_033554.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_291032.2 Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21315
Clone ID Related Accession (Same CDS sequence)	NM_001242524.2 , NM_001242524.1 , NM_033554.3 , NM_001242525.2 , NM_001242525.1
Accession Version	NM_033554.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-03
Organism	Homo sapiens(human)
Product	HLA class II histocompatibility antigen, DP alpha 1 chain precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP338039.1, X00457.1, AL645931.7 and BU687966.1. On Jun 10, 2011 this sequence version replaced NM_033554.2. Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.310161.1, SRR1163655.405167.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGCCCTG AAGACAGAAT GTTCCATATC AGAGCTGTGA TCTTGAGAGC CCTCTCCTTG 
GCTTTCCTGC TGAGTCTCCG AGGAGCTGGG GCCATCAAGG CGGACCATGT GTCAACTTAT 
GCCGCGTTTG TACAGACGCA TAGACCAACA GGGGAGTTTA TGTTTGAATT TGATGAAGAT 
GAGATGTTCT ATGTGGATCT GGACAAGAAG GAGACCGTCT GGCATCTGGA GGAGTTTGGC 
CAAGCCTTTT CCTTTGAGGC TCAGGGCGGG CTGGCTAACA TTGCTATATT GAACAACAAC 
TTGAATACCT TGATCCAGCG TTCCAACCAC ACTCAGGCCA CCAACGATCC CCCTGAGGTG 
ACCGTGTTTC CCAAGGAGCC TGTGGAGCTG GGCCAGCCCA ACACCCTCAT CTGCCACATT 
GACAAGTTCT TCCCACCAGT GCTCAACGTC ACGTGGCTGT GCAACGGGGA GCTGGTCACT 
GAGGGTGTCG CTGAGAGCCT CTTCCTGCCC AGAACAGATT ACAGCTTCCA CAAGTTCCAT 
TACCTGACCT TTGTGCCCTC AGCAGAGGAC TTCTATGACT GCAGGGTGGA GCACTGGGGC 
TTGGACCAGC CGCTCCTCAA GCACTGGGAG GCCCAAGAGC CAATCCAGAT GCCTGAGACA 
ACGGAGACTG TGCTCTGTGC CCTGGGCCTG GTGCTGGGCC TAGTCGGCAT CATCGTGGGC 
ACCGTCCTCA TCATAAAGTC TCTGCGTTCT GGCCATGACC CCCGGGCCCA GGGGACCCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_291032.2
CDS	108..890
Translation	MRPEDRMFHIRAVILRALSLAFLLSLRGAGAIKADHVSTYAAFVQTHRPTGEFMFEFDEDEMFYVDLDKKETVWHLEEFGQAFSFEAQGGLANIAILNNNLNTLIQRSNHTQATNDPPEVTVFPKEPVELGQPNTLICHIDKFFPPVLNVTWLCNGELVTEGVAESLFLPRTDYSFHKFHYLTFVPSAEDFYDCRVEHWGLDQPLLKHWEAQEPIQMPETTETVLCALGLVLGLVGIIVGTVLIIKSLRSGHDPRAQGTL

Target ORF information:

RefSeq Version	NM_033554.3
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033554.3

ORF Insert Sequence:

ATGCGCCCTG AAGACAGAAT GTTCCATATC AGAGCTGTGA TCTTGAGAGC CCTCTCCTTG 
GCTTTCCTGC TGAGTCTCCG AGGAGCTGGG GCCATCAAGG CGGACCATGT GTCAACTTAT 
GCCGCGTTTG TACAGACGCA TAGACCAACA GGGGAGTTTA TGTTTGAATT TGATGAAGAT 
GAGATGTTCT ATGTGGATCT GGACAAGAAG GAGACCGTCT GGCATCTGGA GGAGTTTGGC 
CAAGCCTTTT CCTTTGAGGC TCAGGGCGGG CTGGCTAACA TTGCTATATT GAACAACAAC 
TTGAATACCT TGATCCAGCG TTCCAACCAC ACTCAGGCCA CCAACGATCC CCCTGAGGTG 
ACCGTGTTTC CCAAGGAGCC TGTGGAGCTG GGCCAGCCCA ACACCCTCAT CTGCCACATT 
GACAAGTTCT TCCCACCAGT GCTCAACGTC ACGTGGCTGT GCAACGGGGA GCTGGTCACT 
GAGGGTGTCG CTGAGAGCCT CTTCCTGCCC AGAACAGATT ACAGCTTCCA CAAGTTCCAT 
TACCTGACCT TTGTGCCCTC AGCAGAGGAC TTCTATGACT GCAGGGTGGA GCACTGGGGC 
TTGGACCAGC CGCTCCTCAA GCACTGGGAG GCCCAAGAGC CAATCCAGAT GCCTGAGACA 
ACGGAGACTG TGCTCTGTGC CCTGGGCCTG GTGCTGGGCC TAGTCGGCAT CATCGTGGGC 
ACCGTCCTCA TCATAAAGTC TCTGCGTTCT GGCCATGACC CCCGGGCCCA GGGGACCCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HLA-DPA1 ( NM_001242525.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001229454.1 Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu21315
Clone ID Related Accession (Same CDS sequence)	NM_001242524.2 , NM_001242524.1 , NM_033554.3 , NM_001242525.2 , NM_001242525.1
Accession Version	NM_001242525.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-03
Organism	Homo sapiens(human)
Product	HLA class II histocompatibility antigen, DP alpha 1 chain precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI553587.1, X00457.1, AL645931.7 and BU687966.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_001242525.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: SRR1163658.310161.1, SRR1163657.260045.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCCCTG AAGACAGAAT GTTCCATATC AGAGCTGTGA TCTTGAGAGC CCTCTCCTTG 
GCTTTCCTGC TGAGTCTCCG AGGAGCTGGG GCCATCAAGG CGGACCATGT GTCAACTTAT 
GCCGCGTTTG TACAGACGCA TAGACCAACA GGGGAGTTTA TGTTTGAATT TGATGAAGAT 
GAGATGTTCT ATGTGGATCT GGACAAGAAG GAGACCGTCT GGCATCTGGA GGAGTTTGGC 
CAAGCCTTTT CCTTTGAGGC TCAGGGCGGG CTGGCTAACA TTGCTATATT GAACAACAAC 
TTGAATACCT TGATCCAGCG TTCCAACCAC ACTCAGGCCA CCAACGATCC CCCTGAGGTG 
ACCGTGTTTC CCAAGGAGCC TGTGGAGCTG GGCCAGCCCA ACACCCTCAT CTGCCACATT 
GACAAGTTCT TCCCACCAGT GCTCAACGTC ACGTGGCTGT GCAACGGGGA GCTGGTCACT 
GAGGGTGTCG CTGAGAGCCT CTTCCTGCCC AGAACAGATT ACAGCTTCCA CAAGTTCCAT 
TACCTGACCT TTGTGCCCTC AGCAGAGGAC TTCTATGACT GCAGGGTGGA GCACTGGGGC 
TTGGACCAGC CGCTCCTCAA GCACTGGGAG GCCCAAGAGC CAATCCAGAT GCCTGAGACA 
ACGGAGACTG TGCTCTGTGC CCTGGGCCTG GTGCTGGGCC TAGTCGGCAT CATCGTGGGC 
ACCGTCCTCA TCATAAAGTC TCTGCGTTCT GGCCATGACC CCCGGGCCCA GGGGACCCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001229454.1
CDS	93..875
Translation	MRPEDRMFHIRAVILRALSLAFLLSLRGAGAIKADHVSTYAAFVQTHRPTGEFMFEFDEDEMFYVDLDKKETVWHLEEFGQAFSFEAQGGLANIAILNNNLNTLIQRSNHTQATNDPPEVTVFPKEPVELGQPNTLICHIDKFFPPVLNVTWLCNGELVTEGVAESLFLPRTDYSFHKFHYLTFVPSAEDFYDCRVEHWGLDQPLLKHWEAQEPIQMPETTETVLCALGLVLGLVGIIVGTVLIIKSLRSGHDPRAQGTL

Target ORF information:

RefSeq Version	NM_001242525.2
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001242525.2

ORF Insert Sequence:

ATGCGCCCTG AAGACAGAAT GTTCCATATC AGAGCTGTGA TCTTGAGAGC CCTCTCCTTG 
GCTTTCCTGC TGAGTCTCCG AGGAGCTGGG GCCATCAAGG CGGACCATGT GTCAACTTAT 
GCCGCGTTTG TACAGACGCA TAGACCAACA GGGGAGTTTA TGTTTGAATT TGATGAAGAT 
GAGATGTTCT ATGTGGATCT GGACAAGAAG GAGACCGTCT GGCATCTGGA GGAGTTTGGC 
CAAGCCTTTT CCTTTGAGGC TCAGGGCGGG CTGGCTAACA TTGCTATATT GAACAACAAC 
TTGAATACCT TGATCCAGCG TTCCAACCAC ACTCAGGCCA CCAACGATCC CCCTGAGGTG 
ACCGTGTTTC CCAAGGAGCC TGTGGAGCTG GGCCAGCCCA ACACCCTCAT CTGCCACATT 
GACAAGTTCT TCCCACCAGT GCTCAACGTC ACGTGGCTGT GCAACGGGGA GCTGGTCACT 
GAGGGTGTCG CTGAGAGCCT CTTCCTGCCC AGAACAGATT ACAGCTTCCA CAAGTTCCAT 
TACCTGACCT TTGTGCCCTC AGCAGAGGAC TTCTATGACT GCAGGGTGGA GCACTGGGGC 
TTGGACCAGC CGCTCCTCAA GCACTGGGAG GCCCAAGAGC CAATCCAGAT GCCTGAGACA 
ACGGAGACTG TGCTCTGTGC CCTGGGCCTG GTGCTGGGCC TAGTCGGCAT CATCGTGGGC 
ACCGTCCTCA TCATAAAGTC TCTGCGTTCT GGCCATGACC CCCGGGCCCA GGGGACCCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HLA-DPA1 ( NM_001242525.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001229454.1 Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 3, mRNA.

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CloneID	OHu21315
Clone ID Related Accession (Same CDS sequence)	NM_001242524.2 , NM_001242524.1 , NM_033554.3 , NM_001242525.2 , NM_001242525.1
Accession Version	NM_001242525.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	HLA class II histocompatibility antigen, DP alpha 1 chain precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI553587.1, X00457.1, AL645931.7 and BU687966.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: SRR1163657.436368.1, SRR1163655.623914.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCCCTG AAGACAGAAT GTTCCATATC AGAGCTGTGA TCTTGAGAGC CCTCTCCTTG 
GCTTTCCTGC TGAGTCTCCG AGGAGCTGGG GCCATCAAGG CGGACCATGT GTCAACTTAT 
GCCGCGTTTG TACAGACGCA TAGACCAACA GGGGAGTTTA TGTTTGAATT TGATGAAGAT 
GAGATGTTCT ATGTGGATCT GGACAAGAAG GAGACCGTCT GGCATCTGGA GGAGTTTGGC 
CAAGCCTTTT CCTTTGAGGC TCAGGGCGGG CTGGCTAACA TTGCTATATT GAACAACAAC 
TTGAATACCT TGATCCAGCG TTCCAACCAC ACTCAGGCCA CCAACGATCC CCCTGAGGTG 
ACCGTGTTTC CCAAGGAGCC TGTGGAGCTG GGCCAGCCCA ACACCCTCAT CTGCCACATT 
GACAAGTTCT TCCCACCAGT GCTCAACGTC ACGTGGCTGT GCAACGGGGA GCTGGTCACT 
GAGGGTGTCG CTGAGAGCCT CTTCCTGCCC AGAACAGATT ACAGCTTCCA CAAGTTCCAT 
TACCTGACCT TTGTGCCCTC AGCAGAGGAC TTCTATGACT GCAGGGTGGA GCACTGGGGC 
TTGGACCAGC CGCTCCTCAA GCACTGGGAG GCCCAAGAGC CAATCCAGAT GCCTGAGACA 
ACGGAGACTG TGCTCTGTGC CCTGGGCCTG GTGCTGGGCC TAGTCGGCAT CATCGTGGGC 
ACCGTCCTCA TCATAAAGTC TCTGCGTTCT GGCCATGACC CCCGGGCCCA GGGGACCCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001229454.1
CDS	123..905
Translation	MRPEDRMFHIRAVILRALSLAFLLSLRGAGAIKADHVSTYAAFVQTHRPTGEFMFEFDEDEMFYVDLDKKETVWHLEEFGQAFSFEAQGGLANIAILNNNLNTLIQRSNHTQATNDPPEVTVFPKEPVELGQPNTLICHIDKFFPPVLNVTWLCNGELVTEGVAESLFLPRTDYSFHKFHYLTFVPSAEDFYDCRVEHWGLDQPLLKHWEAQEPIQMPETTETVLCALGLVLGLVGIIVGTVLIIKSLRSGHDPRAQGTL

Target ORF information:

RefSeq Version	NM_001242525.1
Organism	Homo sapiens(human)
Definition	Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001242525.1

ORF Insert Sequence:

ATGCGCCCTG AAGACAGAAT GTTCCATATC AGAGCTGTGA TCTTGAGAGC CCTCTCCTTG 
GCTTTCCTGC TGAGTCTCCG AGGAGCTGGG GCCATCAAGG CGGACCATGT GTCAACTTAT 
GCCGCGTTTG TACAGACGCA TAGACCAACA GGGGAGTTTA TGTTTGAATT TGATGAAGAT 
GAGATGTTCT ATGTGGATCT GGACAAGAAG GAGACCGTCT GGCATCTGGA GGAGTTTGGC 
CAAGCCTTTT CCTTTGAGGC TCAGGGCGGG CTGGCTAACA TTGCTATATT GAACAACAAC 
TTGAATACCT TGATCCAGCG TTCCAACCAC ACTCAGGCCA CCAACGATCC CCCTGAGGTG 
ACCGTGTTTC CCAAGGAGCC TGTGGAGCTG GGCCAGCCCA ACACCCTCAT CTGCCACATT 
GACAAGTTCT TCCCACCAGT GCTCAACGTC ACGTGGCTGT GCAACGGGGA GCTGGTCACT 
GAGGGTGTCG CTGAGAGCCT CTTCCTGCCC AGAACAGATT ACAGCTTCCA CAAGTTCCAT 
TACCTGACCT TTGTGCCCTC AGCAGAGGAC TTCTATGACT GCAGGGTGGA GCACTGGGGC 
TTGGACCAGC CGCTCCTCAA GCACTGGGAG GCCCAAGAGC CAATCCAGAT GCCTGAGACA 
ACGGAGACTG TGCTCTGTGC CCTGGGCCTG GTGCTGGGCC TAGTCGGCAT CATCGTGGGC 
ACCGTCCTCA TCATAAAGTC TCTGCGTTCT GGCCATGACC CCCGGGCCCA GGGGACCCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic Polymorphism and Decreased Expression of HLA class II DP Genes are Associated with HBV Reactivation in Patients Treated with Immunomodulatory Agents.
Journal of medical virology(2017 Dec)
Matsuda H,Hiramatsu K,Akazawa Y,Nosaka T,Saito Y,Ozaki Y,Hayama R,Takahashi K,Naito T,Ofuji K,Ohtani M,Nemoto T,Hida Y,Kimura H,Soya Y,Nakamoto Y

Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features.
International archives of allergy and immunology172(3)150-160(2017)
Takejima P,Agondi RC,Rodrigues H,Aun MV,Kalil J,Giavina-Bianchi P

Genetic risk factors for sclerotic graft-versus-host disease.
Blood128(11)1516-24(2016 09)
Inamoto Y,Martin PJ,Flowers ME,Lee SJ,Carpenter PA,Warren EH,Geraghty DE,Lee N,Boeckh MJ,Storer BE,Levine DM,Fan W,Zhao LP,Hansen JA

Protective effects of HLA-DPA1/DPB1 variants against Hepatitis B virus infection in an Indonesian population.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases41177-184(2016 07)
Wasityastuti W,Yano Y,Ratnasari N,Triyono T,Triwikatmani C,Indrarti F,Heriyanto DS,Yamani LN,Liang Y,Utsumi T,Hayashi Y

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HLA-DPA1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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