H3-3A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H3-3A
Entrez Gene ID	3020
Full Name	H3 histone family member 3A
Synonyms	H3.3A,H3F3
General protein information	Preferred Names H3 histone family member 3A Names histone H3.3 H3 histone, family 3A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q42.12
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Jul 2008].
Disorder MIM:	601128

mRNA and Protein(s)

mRNA	Protein	Name
NM_002107.4	NP_002098.1	histone H3.3
NM_002107.6	NP_002098.1	histone H3.3
NM_002107.5	NP_002098.1	histone H3.3
NM_002107.7	NP_002098.1	histone H3.3

Pathways from BioSystems

Homologies

Homo sapiens (human)	H3F3B	NP_005315.1
Mus musculus (house mouse)	H3f3b	NP_032237.1
Gallus gallus (chicken)	H3F3B	NP_990627.1
Pan troglodytes (chimpanzee)	H3F3B	XP_003315784.1
Pan troglodytes (chimpanzee)	H3F3A	XP_003339055.1
	LOC707040	XP_001105140.1
Rattus norvegicus (Norway rat)	H3f3b	NP_446437.1
Drosophila melanogaster (fruit fly)	His3:CG33857	NP_001027373.1
Homo sapiens (human)	H3F3A	NP_002098.1
Mus musculus (house mouse)	H3f3a	NP_032236.1
Gallus gallus (chicken)	LOC100859629	XP_003643522.1
Xenopus tropicalis (tropical clawed frog)	LOC101730642	XP_004913911.1
Canis lupus familiaris (dog)	H3F3B	XP_537232.1
Bos taurus (cattle)	H3F3A	NP_001014411.1
Bos taurus (cattle)	H3F3B	NP_001229500.1
Pan troglodytes (chimpanzee)	HIST1H3A	NP_001092038.1
Rattus norvegicus (Norway rat)	LOC100361558	XP_002728089.1
Danio rerio (zebrafish)	LOC565028	XP_693431.3

Gene Ontology
Bibliography

Related articles in PubMed

Significance of H3K27M mutation with specific histomorphological features and associated molecular alterations in pediatric high-grade glial tumors.
Bozkurt SU, Dagcinar A, Tanrikulu B, Comunoglu N, Meydan BC, Ozek M, Oz B
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery34(1)107-116(2018 Jan)

Histone 3.3 mutations in giant cell tumor and giant cell-rich sarcomas of bone.
Righi A, Mancini I, Gambarotti M, Picci P, Gamberi G, Marraccini C, Dei Tos AP, Simi L, Pinzani P, Franchi A
Human pathology68128-135(2017 10)

Diagnostic value of histone 3 mutations in osteoclast-rich bone tumors.
Nohr E, Lee LH, Cates JM, Perizzolo M, Itani D
Human pathology68119-127(2017 10)

Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation.
Gates LA, Shi J, Rohira AD, Feng Q, Zhu B, Bedford MT, Sagum CA, Jung SY, Qin J, Tsai MJ, Tsai SY, Li W, Foulds CE, O'Malley BW
The Journal of biological chemistry292(35)14456-14472(2017 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

H3F3A mutational testing may be a useful adjunct to differentiate giant cell tumor of bone from giant cell-rich sarcoma.
Title: Histone 3.3 mutations in giant cell tumor and giant cell-rich sarcomas of bone.

H3F3A is the most frequently mutated giant cell tumor of bone driver gene. H3F3A mutations are not present in atypical giant cell tumor of bone.
Title: Highly recurrent H3F3A mutations with additional epigenetic regulator alterations in giant cell tumor of bone.

Report H3F3A/B mutations in cell tumors of bone, chondroblastomas, and aneurysmal bone cysts.
Title: Diagnostic value of histone 3 mutations in osteoclast-rich bone tumors.

Data suggest that H3K9ac (histone 3 lysine 9 acetylation) serves as a substrate for direct binding of the SEC (super elongation complex) to chromatin; at select gene promoters, H3K9ac loss or SEC depletion appears to reduce gene expression.
Title: Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation.

We determined the incidence of H3.3 G34 mutations in primary malignant bone tumors as assessed by genotype and H3.3 G34W immunostaining
Title: H3F3A (Histone 3.3) G34W Immunohistochemistry: A Reliable Marker Defining Benign and Malignant Giant Cell Tumor of Bone.

The following H3-3A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H3-3A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25077	NM_002107.7 Latest version!	Homo sapiens H3.3 histone A (H3-3A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu25077	NM_002107.4	Homo sapiens H3 histone family member 3A (H3F3A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu25077	NM_002107.5	Homo sapiens H3 histone family member 3A (H3F3A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu25077	NM_002107.6	Homo sapiens H3 histone family member 3A (H3F3A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H3-3A ( NM_002107.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002098.1 Homo sapiens H3 histone family member 3A (H3F3A), mRNA.

Price & Availability↑

CloneID	OHu25077
Clone ID Related Accession (Same CDS sequence)	NM_002107.4 , NM_002107.6 , NM_002107.5 , NM_002107.7
Accession Version	NM_002107.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	histone H3.3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK311905.1, BC029405.1, BC066901.1 and CA310975.1. On Jan 14, 2011 this sequence version replaced NM_002107.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.116741.1, SRR1163658.479553.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-independent histone :: PMID: 8586426 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCGTA CAAAGCAGAC TGCCCGCAAA TCGACCGGTG GTAAAGCACC CAGGAAGCAA 
CTGGCTACAA AAGCCGCTCG CAAGAGTGCG CCCTCTACTG GAGGGGTGAA GAAACCTCAT 
CGTTACAGGC CTGGTACTGT GGCGCTCCGT GAAATTAGAC GTTATCAGAA GTCCACTGAA 
CTTCTGATTC GCAAACTTCC CTTCCAGCGT CTGGTGCGAG AAATTGCTCA GGACTTTAAA 
ACAGATCTGC GCTTCCAGAG CGCAGCTATC GGTGCTTTGC AGGAGGCAAG TGAGGCCTAT 
CTGGTTGGCC TTTTTGAAGA CACCAACCTG TGTGCTATCC ATGCCAAACG TGTAACAATT 
ATGCCAAAAG ACATCCAGCT AGCACGCCGC ATACGTGGAG AACGTGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002098.1
CDS	129..539
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_002107.4
Organism	Homo sapiens(human)
Definition	Homo sapiens H3 histone family member 3A (H3F3A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002107.4

ORF Insert Sequence:

ATGGCTCGTA CAAAGCAGAC TGCCCGCAAA TCGACCGGTG GTAAAGCACC CAGGAAGCAA 
CTGGCTACAA AAGCCGCTCG CAAGAGTGCG CCCTCTACTG GAGGGGTGAA GAAACCTCAT 
CGTTACAGGC CTGGTACTGT GGCGCTCCGT GAAATTAGAC GTTATCAGAA GTCCACTGAA 
CTTCTGATTC GCAAACTTCC CTTCCAGCGT CTGGTGCGAG AAATTGCTCA GGACTTTAAA 
ACAGATCTGC GCTTCCAGAG CGCAGCTATC GGTGCTTTGC AGGAGGCAAG TGAGGCCTAT 
CTGGTTGGCC TTTTTGAAGA CACCAACCTG TGTGCTATCC ATGCCAAACG TGTAACAATT 
ATGCCAAAAG ACATCCAGCT AGCACGCCGC ATACGTGGAG AACGTGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H3-3A ( NM_002107.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_002098.1 Homo sapiens H3 histone family member 3A (H3F3A), mRNA.

Price & Availability↑

CloneID	OHu25077
Clone ID Related Accession (Same CDS sequence)	NM_002107.4 , NM_002107.6 , NM_002107.5 , NM_002107.7
Accession Version	NM_002107.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-03
Organism	Homo sapiens(human)
Product	histone H3.3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL512343.21. This sequence is a reference standard in the RefSeqGene project. On May 23, 2019 this sequence version replaced NM_002107.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.964726.1, CD048246.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 8586426 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCGTA CAAAGCAGAC TGCCCGCAAA TCGACCGGTG GTAAAGCACC CAGGAAGCAA 
CTGGCTACAA AAGCCGCTCG CAAGAGTGCG CCCTCTACTG GAGGGGTGAA GAAACCTCAT 
CGTTACAGGC CTGGTACTGT GGCGCTCCGT GAAATTAGAC GTTATCAGAA GTCCACTGAA 
CTTCTGATTC GCAAACTTCC CTTCCAGCGT CTGGTGCGAG AAATTGCTCA GGACTTTAAA 
ACAGATCTGC GCTTCCAGAG CGCAGCTATC GGTGCTTTGC AGGAGGCAAG TGAGGCCTAT 
CTGGTTGGCC TTTTTGAAGA CACCAACCTG TGTGCTATCC ATGCCAAACG TGTAACAATT 
ATGCCAAAAG ACATCCAGCT AGCACGCCGC ATACGTGGAG AACGTGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002098.1
CDS	120..530
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_002107.6
Organism	Homo sapiens(human)
Definition	Homo sapiens H3 histone family member 3A (H3F3A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002107.6

ORF Insert Sequence:

ATGGCTCGTA CAAAGCAGAC TGCCCGCAAA TCGACCGGTG GTAAAGCACC CAGGAAGCAA 
CTGGCTACAA AAGCCGCTCG CAAGAGTGCG CCCTCTACTG GAGGGGTGAA GAAACCTCAT 
CGTTACAGGC CTGGTACTGT GGCGCTCCGT GAAATTAGAC GTTATCAGAA GTCCACTGAA 
CTTCTGATTC GCAAACTTCC CTTCCAGCGT CTGGTGCGAG AAATTGCTCA GGACTTTAAA 
ACAGATCTGC GCTTCCAGAG CGCAGCTATC GGTGCTTTGC AGGAGGCAAG TGAGGCCTAT 
CTGGTTGGCC TTTTTGAAGA CACCAACCTG TGTGCTATCC ATGCCAAACG TGTAACAATT 
ATGCCAAAAG ACATCCAGCT AGCACGCCGC ATACGTGGAG AACGTGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H3-3A ( NM_002107.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002098.1 Homo sapiens H3 histone family member 3A (H3F3A), mRNA.

Price & Availability↑

CloneID	OHu25077
Clone ID Related Accession (Same CDS sequence)	NM_002107.4 , NM_002107.6 , NM_002107.5 , NM_002107.7
Accession Version	NM_002107.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-27
Organism	Homo sapiens(human)
Product	histone H3.3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK311905.1, BC029405.1, BC066901.1, CA310975.1 and AL512343.21. On Nov 23, 2018 this sequence version replaced NM_002107.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM785212.1, SRR1163658.479553.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-independent histone :: PMID: 8586426 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCGTA CAAAGCAGAC TGCCCGCAAA TCGACCGGTG GTAAAGCACC CAGGAAGCAA 
CTGGCTACAA AAGCCGCTCG CAAGAGTGCG CCCTCTACTG GAGGGGTGAA GAAACCTCAT 
CGTTACAGGC CTGGTACTGT GGCGCTCCGT GAAATTAGAC GTTATCAGAA GTCCACTGAA 
CTTCTGATTC GCAAACTTCC CTTCCAGCGT CTGGTGCGAG AAATTGCTCA GGACTTTAAA 
ACAGATCTGC GCTTCCAGAG CGCAGCTATC GGTGCTTTGC AGGAGGCAAG TGAGGCCTAT 
CTGGTTGGCC TTTTTGAAGA CACCAACCTG TGTGCTATCC ATGCCAAACG TGTAACAATT 
ATGCCAAAAG ACATCCAGCT AGCACGCCGC ATACGTGGAG AACGTGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002098.1
CDS	120..530
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_002107.5
Organism	Homo sapiens(human)
Definition	Homo sapiens H3 histone family member 3A (H3F3A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002107.5

ORF Insert Sequence:

ATGGCTCGTA CAAAGCAGAC TGCCCGCAAA TCGACCGGTG GTAAAGCACC CAGGAAGCAA 
CTGGCTACAA AAGCCGCTCG CAAGAGTGCG CCCTCTACTG GAGGGGTGAA GAAACCTCAT 
CGTTACAGGC CTGGTACTGT GGCGCTCCGT GAAATTAGAC GTTATCAGAA GTCCACTGAA 
CTTCTGATTC GCAAACTTCC CTTCCAGCGT CTGGTGCGAG AAATTGCTCA GGACTTTAAA 
ACAGATCTGC GCTTCCAGAG CGCAGCTATC GGTGCTTTGC AGGAGGCAAG TGAGGCCTAT 
CTGGTTGGCC TTTTTGAAGA CACCAACCTG TGTGCTATCC ATGCCAAACG TGTAACAATT 
ATGCCAAAAG ACATCCAGCT AGCACGCCGC ATACGTGGAG AACGTGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H3-3A ( NM_002107.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_002098.1 Homo sapiens H3.3 histone A (H3-3A), mRNA.

Price & Availability↑

CloneID	OHu25077
Clone ID Related Accession (Same CDS sequence)	NM_002107.4 , NM_002107.6 , NM_002107.5 , NM_002107.7
Accession Version	NM_002107.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	histone H3.3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL512343.21. On Dec 3, 2019 this sequence version replaced NM_002107.6. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD048246.1, BM785212.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 8586426 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCGTA CAAAGCAGAC TGCCCGCAAA TCGACCGGTG GTAAAGCACC CAGGAAGCAA 
CTGGCTACAA AAGCCGCTCG CAAGAGTGCG CCCTCTACTG GAGGGGTGAA GAAACCTCAT 
CGTTACAGGC CTGGTACTGT GGCGCTCCGT GAAATTAGAC GTTATCAGAA GTCCACTGAA 
CTTCTGATTC GCAAACTTCC CTTCCAGCGT CTGGTGCGAG AAATTGCTCA GGACTTTAAA 
ACAGATCTGC GCTTCCAGAG CGCAGCTATC GGTGCTTTGC AGGAGGCAAG TGAGGCCTAT 
CTGGTTGGCC TTTTTGAAGA CACCAACCTG TGTGCTATCC ATGCCAAACG TGTAACAATT 
ATGCCAAAAG ACATCCAGCT AGCACGCCGC ATACGTGGAG AACGTGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002098.1
CDS	120..530
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_002107.7
Organism	Homo sapiens(human)
Definition	Homo sapiens H3.3 histone A (H3-3A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002107.7

ORF Insert Sequence:

ATGGCTCGTA CAAAGCAGAC TGCCCGCAAA TCGACCGGTG GTAAAGCACC CAGGAAGCAA 
CTGGCTACAA AAGCCGCTCG CAAGAGTGCG CCCTCTACTG GAGGGGTGAA GAAACCTCAT 
CGTTACAGGC CTGGTACTGT GGCGCTCCGT GAAATTAGAC GTTATCAGAA GTCCACTGAA 
CTTCTGATTC GCAAACTTCC CTTCCAGCGT CTGGTGCGAG AAATTGCTCA GGACTTTAAA 
ACAGATCTGC GCTTCCAGAG CGCAGCTATC GGTGCTTTGC AGGAGGCAAG TGAGGCCTAT 
CTGGTTGGCC TTTTTGAAGA CACCAACCTG TGTGCTATCC ATGCCAAACG TGTAACAATT 
ATGCCAAAAG ACATCCAGCT AGCACGCCGC ATACGTGGAG AACGTGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Significance of H3K27M mutation with specific histomorphological features and associated molecular alterations in pediatric high-grade glial tumors.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery34(1)107-116(2018 Jan)
Bozkurt SU,Dagcinar A,Tanrikulu B,Comunoglu N,Meydan BC,Ozek M,Oz B

Histone 3.3 mutations in giant cell tumor and giant cell-rich sarcomas of bone.
Human pathology68128-135(2017 10)
Righi A,Mancini I,Gambarotti M,Picci P,Gamberi G,Marraccini C,Dei Tos AP,Simi L,Pinzani P,Franchi A

Diagnostic value of histone 3 mutations in osteoclast-rich bone tumors.
Human pathology68119-127(2017 10)
Nohr E,Lee LH,Cates JM,Perizzolo M,Itani D

Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation.
The Journal of biological chemistry292(35)14456-14472(2017 09)
Gates LA,Shi J,Rohira AD,Feng Q,Zhu B,Bedford MT,Sagum CA,Jung SY,Qin J,Tsai MJ,Tsai SY,Li W,Foulds CE,O'Malley BW

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H3-3A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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