H2AFZ cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2AFZ
Entrez Gene ID	3015
Full Name	H2A histone family member Z
Synonyms	H2A.Z-1,H2A.z,H2A/z,H2AZ
General protein information	Preferred Names H2A histone family member Z Names histone H2A.Z H2AZ histone
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q23
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008].
Disorder MIM:	142763

mRNA and Protein(s)

mRNA	Protein	Name
NM_002106.4	NP_002097.1	histone H2A.Z
NM_002106.3	NP_002097.1	histone H2A.Z

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	H2afz	NP_073165.1
Arabidopsis thaliana (thale cress)	HTA9	NP_175683.1
Homo sapiens (human)	H2AFZ	NP_002097.1
Bos taurus (cattle)	H2AFZ	NP_777234.1
Xenopus tropicalis (tropical clawed frog)	h2afz	NP_001005097.1
Danio rerio (zebrafish)	h2afvb	NP_001036788.1
Gallus gallus (chicken)	H2AFZ	NP_001026545.1
Pan troglodytes (chimpanzee)	H2AFZ	XP_517363.3
	H2AFZ	XP_001108128.1
Canis lupus familiaris (dog)	H2AFZ	XP_535671.1
Mus musculus (house mouse)	H2afz	NP_058030.1

Gene Ontology
Bibliography

Related articles in PubMed

Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer.
Vald?s-Mora F, Gould CM, Colino-Sanguino Y, Qu W, Song JZ, Taylor KM, Buske FA, Statham AL, Nair SS, Armstrong NJ, Kench JG, Lee KML, Horvath LG, Qiu M, Ilinykh A, Yeo-Teh NS, Gallego-Ortega D, Stirzaker C, Clark SJ
Nature communications8(1)1346(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results indicate that accumulation of H2A.Z within repressed genes can also be a consequence of the repression of gene transcription rather than an active mechanism required to establish the repression.
Title: Global inhibition of transcription causes an increase in histone H2A.Z incorporation within gene bodies.

Thus, PWWP2A is a novel H2A.Z-specific multivalent chromatin binder providing a surprising link between H2A.Z, chromosome segregation, and organ development.
Title: Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation.

SMYD3-mediated H2A.Z.1K101 dimethylation activates cyclin A1 expression and contributes to driving the proliferation of breast cancer cells.
Title: SMYD3-Mediated H2A.Z.1 Methylation Promotes Cell Cycle and Cancer Proliferation.

Monoubiquitination of histone H2B blocks eviction of histone variant H2A.Z from inducible enhancers.
Title: Monoubiquitination of Histone H2B Blocks Eviction of Histone Variant H2A.Z from Inducible Enhancers.

Crystal structure results show that the flexible character of the H2A.Z L1 loop plays an essential role in forming the stable heterotypic H2A.Z/H2A nucleosome.
Title: Crystal structures of heterotypic nucleosomes containing histones H2A.Z and H2A.

The following H2AFZ gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2AFZ cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13187	NM_002106.4 Latest version!	Homo sapiens H2A.Z variant histone 1 (H2AZ1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13187	NM_002106.3	Homo sapiens H2A histone family member Z (H2AFZ), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2AFZ ( NM_002106.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002097.1 Homo sapiens H2A.Z variant histone 1 (H2AZ1), mRNA.

Price & Availability↑

CloneID	OHu13187
Clone ID Related Accession (Same CDS sequence)	NM_002106.4 , NM_002106.3
Accession Version	NM_002106.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-02
Organism	Homo sapiens(human)
Product	histone H2A.Z
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC097460.3. On Nov 23, 2018 this sequence version replaced NM_002106.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC018002.1, BG616099.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000296417.6/ ENSP00000296417.5 RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 25731851 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGGCG GTAAGGCTGG AAAGGACTCC GGAAAGGCCA AGACAAAGGC GGTTTCCCGC 
TCGCAGAGAG CCGGCTTGCA GTTCCCAGTG GGCCGTATTC ATCGACACCT AAAATCTAGG 
ACGACCAGTC ATGGACGTGT GGGCGCGACT GCCGCTGTGT ACAGCGCAGC CATCCTGGAG 
TACCTCACCG CAGAGGTACT TGAACTGGCA GGAAATGCAT CAAAAGACTT AAAGGTAAAG 
CGTATTACCC CTCGTCACTT GCAACTTGCT ATTCGTGGAG ATGAAGAATT GGATTCTCTC 
ATCAAGGCTA CAATTGCTGG TGGTGGTGTC ATTCCACACA TCCACAAATC TCTGATTGGG 
AAGAAAGGAC AACAGAAGAC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002097.1
CDS	106..492
Translation	MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV

Target ORF information:

RefSeq Version	NM_002106.4
Organism	Homo sapiens(human)
Definition	Homo sapiens H2A.Z variant histone 1 (H2AZ1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002106.4

ORF Insert Sequence:

ATGGCTGGCG GTAAGGCTGG AAAGGACTCC GGAAAGGCCA AGACAAAGGC GGTTTCCCGC 
TCGCAGAGAG CCGGCTTGCA GTTCCCAGTG GGCCGTATTC ATCGACACCT AAAATCTAGG 
ACGACCAGTC ATGGACGTGT GGGCGCGACT GCCGCTGTGT ACAGCGCAGC CATCCTGGAG 
TACCTCACCG CAGAGGTACT TGAACTGGCA GGAAATGCAT CAAAAGACTT AAAGGTAAAG 
CGTATTACCC CTCGTCACTT GCAACTTGCT ATTCGTGGAG ATGAAGAATT GGATTCTCTC 
ATCAAGGCTA CAATTGCTGG TGGTGGTGTC ATTCCACACA TCCACAAATC TCTGATTGGG 
AAGAAAGGAC AACAGAAGAC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2AFZ ( NM_002106.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002097.1 Homo sapiens H2A histone family member Z (H2AFZ), mRNA.

Price & Availability↑

CloneID	OHu13187
Clone ID Related Accession (Same CDS sequence)	NM_002106.4 , NM_002106.3
Accession Version	NM_002106.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	histone H2A.Z
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD685635.1, BC020936.1 and M37583.1. On Oct 4, 2004 this sequence version replaced NM_002106.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.699759.1, BC103743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-independent histone :: PMID: 25731851 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGGCG GTAAGGCTGG AAAGGACTCC GGAAAGGCCA AGACAAAGGC GGTTTCCCGC 
TCGCAGAGAG CCGGCTTGCA GTTCCCAGTG GGCCGTATTC ATCGACACCT AAAATCTAGG 
ACGACCAGTC ATGGACGTGT GGGCGCGACT GCCGCTGTGT ACAGCGCAGC CATCCTGGAG 
TACCTCACCG CAGAGGTACT TGAACTGGCA GGAAATGCAT CAAAAGACTT AAAGGTAAAG 
CGTATTACCC CTCGTCACTT GCAACTTGCT ATTCGTGGAG ATGAAGAATT GGATTCTCTC 
ATCAAGGCTA CAATTGCTGG TGGTGGTGTC ATTCCACACA TCCACAAATC TCTGATTGGG 
AAGAAAGGAC AACAGAAGAC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002097.1
CDS	186..572
Translation	MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV

Target ORF information:

RefSeq Version	NM_002106.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H2A histone family member Z (H2AFZ), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002106.3

ORF Insert Sequence:

ATGGCTGGCG GTAAGGCTGG AAAGGACTCC GGAAAGGCCA AGACAAAGGC GGTTTCCCGC 
TCGCAGAGAG CCGGCTTGCA GTTCCCAGTG GGCCGTATTC ATCGACACCT AAAATCTAGG 
ACGACCAGTC ATGGACGTGT GGGCGCGACT GCCGCTGTGT ACAGCGCAGC CATCCTGGAG 
TACCTCACCG CAGAGGTACT TGAACTGGCA GGAAATGCAT CAAAAGACTT AAAGGTAAAG 
CGTATTACCC CTCGTCACTT GCAACTTGCT ATTCGTGGAG ATGAAGAATT GGATTCTCTC 
ATCAAGGCTA CAATTGCTGG TGGTGGTGTC ATTCCACACA TCCACAAATC TCTGATTGGG 
AAGAAAGGAC AACAGAAGAC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer.
Nature communications8(1)1346(2017 Nov)
Vald?s-Mora F,Gould CM,Colino-Sanguino Y,Qu W,Song JZ,Taylor KM,Buske FA,Statham AL,Nair SS,Armstrong NJ,Kench JG,Lee KML,Horvath LG,Qiu M,Ilinykh A,Yeo-Teh NS,Gallego-Ortega D,Stirzaker C,Clark SJ

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H2AFZ cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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