HIST1H1D cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HIST1H1D
Entrez Gene ID	3007
Full Name	histone cluster 1 H1 family member d
Synonyms	H1.3,H1D,H1F3,H1s-2
General protein information	Preferred Names histone cluster 1 H1 family member d Names histone H1.3 H1 histone family, member 3 histone 1, H1d histone H1c histone H1s-2 histone cluster 1, H1d
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.2
Summary	Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015].
Disorder MIM:	142210

mRNA and Protein(s)

mRNA	Protein	Name
NM_005320.3	NP_005311.1	histone H1.3
NM_005320.2	NP_005311.1	histone H1.3

Pathways from BioSystems

Homologies

Homo sapiens (human)	HIST1H1D	NP_005311.1
Pan troglodytes (chimpanzee)	LOC472227	XP_001172808.1
	HIST1H1D	XP_001087823.1
Canis lupus familiaris (dog)	LOC611113	XP_853847.3
Mus musculus (house mouse)	Hist1h1d	NP_663759.3

Gene Ontology
Bibliography

Related articles in PubMed

Role of H1 linker histones in mammalian development and stem cell differentiation.
Pan C, Fan Y
Biochimica et biophysica acta1859(3)496-509(2016 Mar)

Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence.
Chen Y, Hoover ME, Dang X, Shomo AA, Guan X, Marshall AG, Freitas MA, Young NL
Molecular & cellular proteomics : MCP15(3)818-33(2016 Mar)

Proteomic characterization of the nucleolar linker histone H1 interaction network.
Szerlong HJ, Herman JA, Krause CM, DeLuca JG, Skoultchi A, Winger QA, Prenni JE, Hansen JC
Journal of molecular biology427(11)2056-71(2015 Jun)

Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.
Li H, Kaminski MS, Li Y, Yildiz M, Ouillette P, Jones S, Fox H, Jacobi K, Saiya-Cork K, Bixby D, Lebovic D, Roulston D, Shedden K, Sabel M, Marentette L, Cimmino V, Chang AE, Malek SN
Blood123(10)1487-98(2014 Mar)

The C-terminal domain (CTD) in linker histones antagonizes anti-apoptotic proteins to modulate apoptotic outcomes at the mitochondrion.
Garg M, Ramdas N, Vijayalakshmi M, Shivashankar GV, Sarin A
Cell death & disease5e1058(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that histone H1.3, was identified only in non-neoplastic MCF-10A breast cells but not in metastatic MDA-MB-231 breast cancer cells .
Title: Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence.

Histone H1 organizes and maintains an extensive protein-protein interaction network in the nucleolus required for nucleolar structure and integrity.
Title: Proteomic characterization of the nucleolar linker histone H1 interaction network.

Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.
Title: Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.

Integration with apoptotic intermediates (via C-terminal tail interactions) may constitute a more generalized function of linker histone isoforms in apoptotic cascades.
Title: The C-terminal domain (CTD) in linker histones antagonizes anti-apoptotic proteins to modulate apoptotic outcomes at the mitochondrion.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.

The following HIST1H1D gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST1H1D cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24021	NM_005320.3 Latest version!	Homo sapiens H1.3 linker histone, cluster member (H1-3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu24021	NM_005320.2	Homo sapiens histone cluster 1 H1 family member d (HIST1H1D), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HIST1H1D ( NM_005320.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005311.1 Homo sapiens H1.3 linker histone, cluster member (H1-3), mRNA.

Price & Availability↑

CloneID	OHu24021
Clone ID Related Accession (Same CDS sequence)	NM_005320.3 , NM_005320.2
Accession Version	NM_005320.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	histone H1.3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031777.5. On Dec 3, 2019 this sequence version replaced NM_005320.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK312845.1, BC104874.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGAGA CTGCTCCACT TGCTCCTACC ATTCCTGCAC CCGCAGAAAA AACACCTGTG 
AAGAAAAAGG CGAAGAAGGC AGGCGCAACT GCTGGGAAAC GCAAAGCATC CGGACCCCCA 
GTATCTGAGC TTATCACCAA GGCAGTGGCA GCTTCTAAGG AGCGCAGCGG CGTTTCTCTG 
GCCGCGCTTA AGAAAGCGCT TGCGGCTGCT GGCTACGATG TAGAAAAAAA CAACAGCCGT 
ATCAAGCTTG GCCTCAAGAG CTTGGTGAGC AAAGGTACTC TGGTGCAGAC CAAAGGTACC 
GGTGCTTCTG GCTCCTTCAA ACTCAACAAG AAAGCGGCTT CCGGGGAAGG CAAACCCAAG 
GCCAAAAAGG CTGGCGCAGC CAAGCCTAGG AAGCCTGCTG GGGCAGCCAA GAAGCCCAAG 
AAGGTGGCTG GCGCCGCTAC CCCGAAGAAA AGCATCAAAA AGACTCCTAA GAAGGTAAAG 
AAGCCAGCAA CCGCTGCTGG GACCAAGAAA GTGGCCAAGA GTGCGAAAAA GGTGAAAACA 
CCTCAGCCAA AAAAAGCTGC CAAGAGTCCA GCTAAGGCCA AAGCCCCTAA GCCCAAGGCG 
GCCAAGCCTA AGTCGGGGAA GCCGAAGGTT ACAAAGGCAA AGAAGGCAGC TCCGAAGAAA 
AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005311.1
CDS	55..720
Translation	MSETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK

Target ORF information:

RefSeq Version	NM_005320.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H1.3 linker histone, cluster member (H1-3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005320.3

ORF Insert Sequence:

ATGTCGGAGA CTGCTCCACT TGCTCCTACC ATTCCTGCAC CCGCAGAAAA AACACCTGTG 
AAGAAAAAGG CGAAGAAGGC AGGCGCAACT GCTGGGAAAC GCAAAGCATC CGGACCCCCA 
GTATCTGAGC TTATCACCAA GGCAGTGGCA GCTTCTAAGG AGCGCAGCGG CGTTTCTCTG 
GCCGCGCTTA AGAAAGCGCT TGCGGCTGCT GGCTACGATG TAGAAAAAAA CAACAGCCGT 
ATCAAGCTTG GCCTCAAGAG CTTGGTGAGC AAAGGTACTC TGGTGCAGAC CAAAGGTACC 
GGTGCTTCTG GCTCCTTCAA ACTCAACAAG AAAGCGGCTT CCGGGGAAGG CAAACCCAAG 
GCCAAAAAGG CTGGCGCAGC CAAGCCTAGG AAGCCTGCTG GGGCAGCCAA GAAGCCCAAG 
AAGGTGGCTG GCGCCGCTAC CCCGAAGAAA AGCATCAAAA AGACTCCTAA GAAGGTAAAG 
AAGCCAGCAA CCGCTGCTGG GACCAAGAAA GTGGCCAAGA GTGCGAAAAA GGTGAAAACA 
CCTCAGCCAA AAAAAGCTGC CAAGAGTCCA GCTAAGGCCA AAGCCCCTAA GCCCAAGGCG 
GCCAAGCCTA AGTCGGGGAA GCCGAAGGTT ACAAAGGCAA AGAAGGCAGC TCCGAAGAAA 
AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HIST1H1D ( NM_005320.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005311.1 Homo sapiens histone cluster 1 H1 family member d (HIST1H1D), mRNA.

Price & Availability↑

CloneID	OHu24021
Clone ID Related Accession (Same CDS sequence)	NM_005320.3 , NM_005320.2
Accession Version	NM_005320.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Homo sapiens(human)
Product	histone H1.3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M60747.1. On May 13, 2002 this sequence version replaced NM_005320.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGAGA CTGCTCCACT TGCTCCTACC ATTCCTGCAC CCGCAGAAAA AACACCTGTG 
AAGAAAAAGG CGAAGAAGGC AGGCGCAACT GCTGGGAAAC GCAAAGCATC CGGACCCCCA 
GTATCTGAGC TTATCACCAA GGCAGTGGCA GCTTCTAAGG AGCGCAGCGG CGTTTCTCTG 
GCCGCGCTTA AGAAAGCGCT TGCGGCTGCT GGCTACGATG TAGAAAAAAA CAACAGCCGT 
ATCAAGCTTG GCCTCAAGAG CTTGGTGAGC AAAGGTACTC TGGTGCAGAC CAAAGGTACC 
GGTGCTTCTG GCTCCTTCAA ACTCAACAAG AAAGCGGCTT CCGGGGAAGG CAAACCCAAG 
GCCAAAAAGG CTGGCGCAGC CAAGCCTAGG AAGCCTGCTG GGGCAGCCAA GAAGCCCAAG 
AAGGTGGCTG GCGCCGCTAC CCCGAAGAAA AGCATCAAAA AGACTCCTAA GAAGGTAAAG 
AAGCCAGCAA CCGCTGCTGG GACCAAGAAA GTGGCCAAGA GTGCGAAAAA GGTGAAAACA 
CCTCAGCCAA AAAAAGCTGC CAAGAGTCCA GCTAAGGCCA AAGCCCCTAA GCCCAAGGCG 
GCCAAGCCTA AGTCGGGGAA GCCGAAGGTT ACAAAGGCAA AGAAGGCAGC TCCGAAGAAA 
AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005311.1
CDS	56..721
Translation	MSETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK

Target ORF information:

RefSeq Version	NM_005320.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H1 family member d (HIST1H1D), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005320.2

ORF Insert Sequence:

ATGTCGGAGA CTGCTCCACT TGCTCCTACC ATTCCTGCAC CCGCAGAAAA AACACCTGTG 
AAGAAAAAGG CGAAGAAGGC AGGCGCAACT GCTGGGAAAC GCAAAGCATC CGGACCCCCA 
GTATCTGAGC TTATCACCAA GGCAGTGGCA GCTTCTAAGG AGCGCAGCGG CGTTTCTCTG 
GCCGCGCTTA AGAAAGCGCT TGCGGCTGCT GGCTACGATG TAGAAAAAAA CAACAGCCGT 
ATCAAGCTTG GCCTCAAGAG CTTGGTGAGC AAAGGTACTC TGGTGCAGAC CAAAGGTACC 
GGTGCTTCTG GCTCCTTCAA ACTCAACAAG AAAGCGGCTT CCGGGGAAGG CAAACCCAAG 
GCCAAAAAGG CTGGCGCAGC CAAGCCTAGG AAGCCTGCTG GGGCAGCCAA GAAGCCCAAG 
AAGGTGGCTG GCGCCGCTAC CCCGAAGAAA AGCATCAAAA AGACTCCTAA GAAGGTAAAG 
AAGCCAGCAA CCGCTGCTGG GACCAAGAAA GTGGCCAAGA GTGCGAAAAA GGTGAAAACA 
CCTCAGCCAA AAAAAGCTGC CAAGAGTCCA GCTAAGGCCA AAGCCCCTAA GCCCAAGGCG 
GCCAAGCCTA AGTCGGGGAA GCCGAAGGTT ACAAAGGCAA AGAAGGCAGC TCCGAAGAAA 
AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of H1 linker histones in mammalian development and stem cell differentiation.
Biochimica et biophysica acta1859(3)496-509(2016 Mar)
Pan C,Fan Y

Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence.
Molecular & cellular proteomics : MCP15(3)818-33(2016 Mar)
Chen Y,Hoover ME,Dang X,Shomo AA,Guan X,Marshall AG,Freitas MA,Young NL

Proteomic characterization of the nucleolar linker histone H1 interaction network.
Journal of molecular biology427(11)2056-71(2015 Jun)
Szerlong HJ,Herman JA,Krause CM,DeLuca JG,Skoultchi A,Winger QA,Prenni JE,Hansen JC

Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.
Blood123(10)1487-98(2014 Mar)
Li H,Kaminski MS,Li Y,Yildiz M,Ouillette P,Jones S,Fox H,Jacobi K,Saiya-Cork K,Bixby D,Lebovic D,Roulston D,Shedden K,Sabel M,Marentette L,Cimmino V,Chang AE,Malek SN

The C-terminal domain (CTD) in linker histones antagonizes anti-apoptotic proteins to modulate apoptotic outcomes at the mitochondrion.
Cell death & disease5e1058(2014 Feb)
Garg M,Ramdas N,Vijayalakshmi M,Shivashankar GV,Sarin A

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HIST1H1D cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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