SERTAD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SERTAD1
Entrez Gene ID	29950
Full Name	SERTA domain containing 1
Synonyms	SEI1,TRIP-Br1
General protein information	Preferred Names SERTA domain containing 1 Names SERTA domain-containing protein 1 CDK4-binding protein p34SEI CDK4-binding protein p34SEI1 SEI-1 transcriptional regulator interacting with the PHD-bromodomain 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_013376.4	NP_037508.2	SERTA domain-containing protein 1
NM_013376.3	NP_037508.2	SERTA domain-containing protein 1

Pathways from BioSystems

Homologies

	SERTAD1	XP_001096320.1
Rattus norvegicus (Norway rat)	Sertad1	NP_001007736.1
Xenopus tropicalis (tropical clawed frog)	sertad1	XP_004917256.1
Pan troglodytes (chimpanzee)	SERTAD1	XP_512664.3
Homo sapiens (human)	SERTAD1	NP_037508.2
Bos taurus (cattle)	SERTAD1	NP_001035654.1
Canis lupus familiaris (dog)	SERTAD1	XP_866877.1
Mus musculus (house mouse)	Sertad1	NP_061290.1

Gene Ontology
Bibliography

Related articles in PubMed

Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells.
Qiu S, Liu S, Yu T, Yu J, Wang M, Rao Q, Xing H, Tang K, Mi Y, Wang J
BMC cancer17(1)795(2017 Nov)

NMR uncovers direct interaction between human NEDD4-1 and p34
Shrestha P, Yun JH, Ko YJ, Yeon KJ, Kim D, Lee H, Jin DH, Nam KY, Yoo HD, Lee W
Biochemical and biophysical research communications490(3)984-990(2017 08)

The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms.
Hu W, Yu X, Liu Z, Sun Y, Chen X, Yang X, Li X, Lam WK, Duan Y, Cao X, Steller H, Liu K, Huang P
eLife6(2017 Jun)

SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer.
You J, Liu J, Bao Y, Wang L, Yu Y, Wang L, Wu D, Liu C, Wang N, Wang F, Wang F, Xu L, Tian X, Liang H, Gao Y, Guan R, Bai J, Meng X, Sun W, Guan XY, Zhang C, Fu S, Jin Y
Cancer letters385271-279(2017 01)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NEDD4-1 recognizes SERTA domain containing proline rich region of p34SEI-1. Residues of NEDD4-1 responsible for direct interaction with p34SEI-1 are identified by NMR titration experiments.
Title: NMR uncovers direct interaction between human NEDD4-1 and p34

SEI1 up-regulation induces genomic instability by inhibiting DNA damage response in ovarian cancer cells.
Title: SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer.

Findings provide evidence that TRIP-Br1 functions as an oncogenic protein by providing cancer cells resistance to the hypoxia-induced cell death of breast cancer cells.
Title: Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines.

TRIP-Br1 confers resistance to serum starvation-induced cell deaths by stabilizing the XIAP protein and inhibiting cellular ROS production.
Title: TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition.

Data demonstrate that p34SEI-1 induces the activation of either AKT or ILK signaling on HER2/neu expression status.
Title: Distinct regulatory effect of the p34SEI-1 oncoprotein on cancer metastasis in HER2/neu-positive and -negative cells.

The following SERTAD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SERTAD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27063	NM_013376.4 Latest version!	Homo sapiens SERTA domain containing 1 (SERTAD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu27063	NM_013376.3	Homo sapiens SERTA domain containing 1 (SERTAD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SERTAD1 ( NM_013376.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_037508.2 Homo sapiens SERTA domain containing 1 (SERTAD1), mRNA.

Price & Availability↑

CloneID	OHu27063
Clone ID Related Accession (Same CDS sequence)	NM_013376.4 , NM_013376.3
Accession Version	NM_013376.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	SERTA domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK074652.1, AA928491.1 and AC010271.8. On Nov 22, 2018 this sequence version replaced NM_013376.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK222970.1, AK074652.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000357949.5/ ENSP00000350633.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGAGCA AGGGTCTGAA GCGGAAACGG GAGGAGGAGG AGGAGAAGGA ACCTCTGGCA 
GTCGACTCCT GGTGGCTAGA TCCTGGCCAC ACAGCGGTGG CACAGGCACC CCCGGCCGTG 
GCCTCTAGCT CCCTCTTTGA CCTCTCAGTG CTCAAGCTCC ACCACAGCCT GCAGCAGAGT 
GAGCCGGACC TGCGGCACCT GGTGCTGGTC GTGAACACTC TGCGGCGCAT CCAGGCGTCC 
ATGGCACCCG CGGCTGCCCT GCCACCTGTG CCTAGCCCAC CTGCAGCCCC CAGTGTGGCT 
GACAACTTAC TGGCAAGCTC GGACGCTGCC CTTTCAGCCT CCATGGCCAG CCTCCTGGAG 
GACCTCAGCC ACATTGAGGG CCTGAGTCAG GCTCCCCAAC CCTTGGCAGA CGAGGGGCCA 
CCAGGCCGTA GCATCGGGGG AGCAGCGCCC AGCCTGGGTG CCTTGGACCT GCTGGGCCCA 
GCCACTGGCT GTCTACTGGA CGATGGGCTT GAGGGCCTGT TTGAGGATAT TGACACCTCT 
ATGTATGACA ATGAACTTTG GGCACCAGCC TCTGAGGGCC TCAAACCAGG CCCTGAGGAT 
GGGCCGGGCA AGGAGGAAGC TCCGGAGCTG GACGAGGCCG AATTGGACTA CCTCATGGAT 
GTGCTGGTGG GCACACAGGC ACTGGAGCGA CCGCCGGGGC CAGGGCGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037508.2
CDS	127..837
Translation	MLSKGLKRKREEEEEKEPLAVDSWWLDPGHTAVAQAPPAVASSSLFDLSVLKLHHSLQQSEPDLRHLVLVVNTLRRIQASMAPAAALPPVPSPPAAPSVADNLLASSDAALSASMASLLEDLSHIEGLSQAPQPLADEGPPGRSIGGAAPSLGALDLLGPATGCLLDDGLEGLFEDIDTSMYDNELWAPASEGLKPGPEDGPGKEEAPELDEAELDYLMDVLVGTQALERPPGPGR

Target ORF information:

RefSeq Version	NM_013376.4
Organism	Homo sapiens(human)
Definition	Homo sapiens SERTA domain containing 1 (SERTAD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013376.4

ORF Insert Sequence:

ATGCTGAGCA AGGGTCTGAA GCGGAAACGG GAGGAGGAGG AGGAGAAGGA ACCTCTGGCA 
GTCGACTCCT GGTGGCTAGA TCCTGGCCAC ACAGCGGTGG CACAGGCACC CCCGGCCGTG 
GCCTCTAGCT CCCTCTTTGA CCTCTCAGTG CTCAAGCTCC ACCACAGCCT GCAGCAGAGT 
GAGCCGGACC TGCGGCACCT GGTGCTGGTC GTGAACACTC TGCGGCGCAT CCAGGCGTCC 
ATGGCACCCG CGGCTGCCCT GCCACCTGTG CCTAGCCCAC CTGCAGCCCC CAGTGTGGCT 
GACAACTTAC TGGCAAGCTC GGACGCTGCC CTTTCAGCCT CCATGGCCAG CCTCCTGGAG 
GACCTCAGCC ACATTGAGGG CCTGAGTCAG GCTCCCCAAC CCTTGGCAGA CGAGGGGCCA 
CCAGGCCGTA GCATCGGGGG AGCAGCGCCC AGCCTGGGTG CCTTGGACCT GCTGGGCCCA 
GCCACTGGCT GTCTACTGGA CGATGGGCTT GAGGGCCTGT TTGAGGATAT TGACACCTCT 
ATGTATGACA ATGAACTTTG GGCACCAGCC TCTGAGGGCC TCAAACCAGG CCCTGAGGAT 
GGGCCGGGCA AGGAGGAAGC TCCGGAGCTG GACGAGGCCG AATTGGACTA CCTCATGGAT 
GTGCTGGTGG GCACACAGGC ACTGGAGCGA CCGCCGGGGC CAGGGCGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SERTAD1 ( NM_013376.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_037508.2 Homo sapiens SERTA domain containing 1 (SERTAD1), mRNA.

Price & Availability↑

CloneID	OHu27063
Clone ID Related Accession (Same CDS sequence)	NM_013376.4 , NM_013376.3
Accession Version	NM_013376.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	SERTA domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK074652.1 and AA928491.1. On Jul 25, 2007 this sequence version replaced NM_013376.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK074652.1, SRR1163657.271602.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END##

ATGCTGAGCA AGGGTCTGAA GCGGAAACGG GAGGAGGAGG AGGAGAAGGA ACCTCTGGCA 
GTCGACTCCT GGTGGCTAGA TCCTGGCCAC ACAGCGGTGG CACAGGCACC CCCGGCCGTG 
GCCTCTAGCT CCCTCTTTGA CCTCTCAGTG CTCAAGCTCC ACCACAGCCT GCAGCAGAGT 
GAGCCGGACC TGCGGCACCT GGTGCTGGTC GTGAACACTC TGCGGCGCAT CCAGGCGTCC 
ATGGCACCCG CGGCTGCCCT GCCACCTGTG CCTAGCCCAC CTGCAGCCCC CAGTGTGGCT 
GACAACTTAC TGGCAAGCTC GGACGCTGCC CTTTCAGCCT CCATGGCCAG CCTCCTGGAG 
GACCTCAGCC ACATTGAGGG CCTGAGTCAG GCTCCCCAAC CCTTGGCAGA CGAGGGGCCA 
CCAGGCCGTA GCATCGGGGG AGCAGCGCCC AGCCTGGGTG CCTTGGACCT GCTGGGCCCA 
GCCACTGGCT GTCTACTGGA CGATGGGCTT GAGGGCCTGT TTGAGGATAT TGACACCTCT 
ATGTATGACA ATGAACTTTG GGCACCAGCC TCTGAGGGCC TCAAACCAGG CCCTGAGGAT 
GGGCCGGGCA AGGAGGAAGC TCCGGAGCTG GACGAGGCCG AATTGGACTA CCTCATGGAT 
GTGCTGGTGG GCACACAGGC ACTGGAGCGA CCGCCGGGGC CAGGGCGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037508.2
CDS	160..870
Translation	MLSKGLKRKREEEEEKEPLAVDSWWLDPGHTAVAQAPPAVASSSLFDLSVLKLHHSLQQSEPDLRHLVLVVNTLRRIQASMAPAAALPPVPSPPAAPSVADNLLASSDAALSASMASLLEDLSHIEGLSQAPQPLADEGPPGRSIGGAAPSLGALDLLGPATGCLLDDGLEGLFEDIDTSMYDNELWAPASEGLKPGPEDGPGKEEAPELDEAELDYLMDVLVGTQALERPPGPGR

Target ORF information:

RefSeq Version	NM_013376.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SERTA domain containing 1 (SERTAD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013376.3

ORF Insert Sequence:

ATGCTGAGCA AGGGTCTGAA GCGGAAACGG GAGGAGGAGG AGGAGAAGGA ACCTCTGGCA 
GTCGACTCCT GGTGGCTAGA TCCTGGCCAC ACAGCGGTGG CACAGGCACC CCCGGCCGTG 
GCCTCTAGCT CCCTCTTTGA CCTCTCAGTG CTCAAGCTCC ACCACAGCCT GCAGCAGAGT 
GAGCCGGACC TGCGGCACCT GGTGCTGGTC GTGAACACTC TGCGGCGCAT CCAGGCGTCC 
ATGGCACCCG CGGCTGCCCT GCCACCTGTG CCTAGCCCAC CTGCAGCCCC CAGTGTGGCT 
GACAACTTAC TGGCAAGCTC GGACGCTGCC CTTTCAGCCT CCATGGCCAG CCTCCTGGAG 
GACCTCAGCC ACATTGAGGG CCTGAGTCAG GCTCCCCAAC CCTTGGCAGA CGAGGGGCCA 
CCAGGCCGTA GCATCGGGGG AGCAGCGCCC AGCCTGGGTG CCTTGGACCT GCTGGGCCCA 
GCCACTGGCT GTCTACTGGA CGATGGGCTT GAGGGCCTGT TTGAGGATAT TGACACCTCT 
ATGTATGACA ATGAACTTTG GGCACCAGCC TCTGAGGGCC TCAAACCAGG CCCTGAGGAT 
GGGCCGGGCA AGGAGGAAGC TCCGGAGCTG GACGAGGCCG AATTGGACTA CCTCATGGAT 
GTGCTGGTGG GCACACAGGC ACTGGAGCGA CCGCCGGGGC CAGGGCGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells.
BMC cancer17(1)795(2017 Nov)
Qiu S,Liu S,Yu T,Yu J,Wang M,Rao Q,Xing H,Tang K,Mi Y,Wang J

NMR uncovers direct interaction between human NEDD4-1 and p34
Biochemical and biophysical research communications490(3)984-990(2017 08)
Shrestha P,Yun JH,Ko YJ,Yeon KJ,Kim D,Lee H,Jin DH,Nam KY,Yoo HD,Lee W

The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms.
eLife6(2017 Jun)
Hu W,Yu X,Liu Z,Sun Y,Chen X,Yang X,Li X,Lam WK,Duan Y,Cao X,Steller H,Liu K,Huang P

SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer.
Cancer letters385271-279(2017 01)
You J,Liu J,Bao Y,Wang L,Yu Y,Wang L,Wu D,Liu C,Wang N,Wang F,Wang F,Xu L,Tian X,Liang H,Gao Y,Guan R,Bai J,Meng X,Sun W,Guan XY,Zhang C,Fu S,Jin Y

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SERTAD1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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