UQCR10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UQCR10
Entrez Gene ID	29796
Full Name	ubiquinol-cytochrome c reductase, complex III subunit X
Synonyms	HSPC051,HSPC119,HSPC151,QCR9,UCCR7.2,UCRC
General protein information	Preferred Names ubiquinol-cytochrome c reductase, complex III subunit X Names cytochrome b-c1 complex subunit 9 cytochrome C1, nonheme 7kDa protein cytochrome c1 non-heme 7 kDa protein ubiquinol-cytochrome c reductase complex (7.2 kD) ubiquinol-cytochrome c reductase complex 7.2 kDa protein ubiquinol-cytochrome c reductase, complex III subunit X, 7.2kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q12.2
Summary	UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008].
Disorder MIM:	610843

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003684.1	NP_001003684.1	cytochrome b-c1 complex subunit 9 isoform b
NM_013387.4	NP_037519.2	cytochrome b-c1 complex subunit 9 isoform a
NM_013387.3	NP_037519.2	cytochrome b-c1 complex subunit 9 isoform a

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	UQCR10	XP_852402.1
Bos taurus (cattle)	UQCR10	NP_001107195.1
Rattus norvegicus (Norway rat)	Uqcr10	NP_001163936.1
Xenopus tropicalis (tropical clawed frog)	uqcr10	NP_001037895.1
Mus musculus (house mouse)	Uqcr10	NP_932096.1
Pan troglodytes (chimpanzee)	UQCR10	XP_001137262.1
Gallus gallus (chicken)	UQCR10	XP_001234250.1
Homo sapiens (human)	UQCR10	NP_037519.2

Gene Ontology
Bibliography

Related articles in PubMed

Novel fusion genes and chimeric transcripts in ependymal tumors.
Olsen TK, Panagopoulos I, Gorunova L, Micci F, Andersen K, Kilen Andersen H, Meling TR, Due-T?nnessen B, Scheie D, Heim S, Brandal P
Genes, chromosomes & cancer55(12)944-953(2016 Dec)

Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing.
Calvo SE, Compton AG, Hershman SG, Lim SC, Lieber DS, Tucker EJ, Laskowski A, Garone C, Liu S, Jaffe DB, Christodoulou J, Fletcher JM, Bruno DL, Goldblatt J, Dimauro S, Thorburn DR, Mootha VK
Science translational medicine4(118)118ra10(2012 Jan)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.
Guzy RD, Hoyos B, Robin E, Chen H, Liu L, Mansfield KD, Simon MC, Hammerling U, Schumacker PT
Cell metabolism1(6)401-8(2005 Jun)

Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants.
Wistow G, Bernstein SL, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K
Molecular vision8171-84(2002 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Reciprocal fusion gene involving UQCR10 and C1orf194 is associated with spinal ependymoma.
Title: Novel fusion genes and chimeric transcripts in ependymal tumors.

Strong candidate gene for mitochondrial disease, based on recessive mutations detected in infantile patients
Title: Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Functionality of complex III of the mitochondrial electron transport chain is required for the hypoxic stabilization of HIF-1 alpha and HIF-2 alpha
Title: Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.

The following UQCR10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UQCR10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29259	NM_013387.4 Latest version!	Homo sapiens ubiquinol-cytochrome c reductase, complex III subunit X (UQCR10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu29894	NM_001003684.1 Latest version!	Homo sapiens ubiquinol-cytochrome c reductase, complex III subunit X (UQCR10), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu29259	NM_013387.3	Homo sapiens ubiquinol-cytochrome c reductase, complex III subunit X (UQCR10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UQCR10 ( NM_013387.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_037519.2 Homo sapiens ubiquinol-cytochrome c reductase, complex III subunit X (UQCR10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29259
Clone ID Related Accession (Same CDS sequence)	NM_013387.4 , NM_013387.3
Accession Version	NM_013387.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 192bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-01
Organism	Homo sapiens(human)
Product	cytochrome b-c1 complex subunit 9 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB999839.1, BI754905.1 and CA311834.1. On Nov 22, 2018 this sequence version replaced NM_013387.3. Transcript Variant: This variant (1) encodes the longer and predominant isoform (a). ##Evidence-Data-START## Transcript exon combination :: SRR5189655.194147.1, SRR5189655.7688.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000330029.6/ ENSP00000332887.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCCG CGACGTTGAC TTCGAAATTG TACTCCCTGC TGTTCCGCAG GACCTCCACC 
TTCGCCCTCA CCATCATCGT GGGCGTCATG TTCTTCGAGC GCGCCTTCGA TCAAGGCGCG 
GACGCTATCT ACGACCACAT CAACGAGGGG AAGCTGTGGA AACACATCAA GCACAAGTAT 
GAGAACAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037519.2
CDS	31..222
Translation	MAAATLTSKLYSLLFRRTSTFALTIIVGVMFFERAFDQGADAIYDHINEGKLWKHIKHKYENK

Target ORF information:

RefSeq Version	NM_013387.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquinol-cytochrome c reductase, complex III subunit X (UQCR10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013387.4

ORF Insert Sequence:

ATGGCGGCCG CGACGTTGAC TTCGAAATTG TACTCCCTGC TGTTCCGCAG GACCTCCACC 
TTCGCCCTCA CCATCATCGT GGGCGTCATG TTCTTCGAGC GCGCCTTCGA TCAAGGCGCG 
GACGCTATCT ACGACCACAT CAACGAGGGG AAGCTGTGGA AACACATCAA GCACAAGTAT 
GAGAACAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UQCR10 ( NM_013387.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_037519.2 Homo sapiens ubiquinol-cytochrome c reductase, complex III subunit X (UQCR10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29259
Clone ID Related Accession (Same CDS sequence)	NM_013387.4 , NM_013387.3
Accession Version	NM_013387.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 192bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	cytochrome b-c1 complex subunit 9 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB999839.1, BI754905.1 and CA311834.1. On Aug 12, 2004 this sequence version replaced NM_013387.2. Transcript Variant: This variant (1) encodes the longer and predominant isoform (a). ##Evidence-Data-START## Transcript exon combination :: ERR279839.9318.1, SRR1660805.402501.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCG CGACGTTGAC TTCGAAATTG TACTCCCTGC TGTTCCGCAG GACCTCCACC 
TTCGCCCTCA CCATCATCGT GGGCGTCATG TTCTTCGAGC GCGCCTTCGA TCAAGGCGCG 
GACGCTATCT ACGACCACAT CAACGAGGGG AAGCTGTGGA AACACATCAA GCACAAGTAT 
GAGAACAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037519.2
CDS	31..222
Translation	MAAATLTSKLYSLLFRRTSTFALTIIVGVMFFERAFDQGADAIYDHINEGKLWKHIKHKYENK

Target ORF information:

RefSeq Version	NM_013387.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquinol-cytochrome c reductase, complex III subunit X (UQCR10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013387.3

ORF Insert Sequence:

ATGGCGGCCG CGACGTTGAC TTCGAAATTG TACTCCCTGC TGTTCCGCAG GACCTCCACC 
TTCGCCCTCA CCATCATCGT GGGCGTCATG TTCTTCGAGC GCGCCTTCGA TCAAGGCGCG 
GACGCTATCT ACGACCACAT CAACGAGGGG AAGCTGTGGA AACACATCAA GCACAAGTAT 
GAGAACAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UQCR10 ( NM_001003684.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001003684.1 Homo sapiens ubiquinol-cytochrome c reductase, complex III subunit X (UQCR10), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29894
Clone ID Related Accession (Same CDS sequence)	NM_001003684.1
Accession Version	NM_001003684.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 189bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	cytochrome b-c1 complex subunit 9 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB999839.1, BU935406.1, CD674029.1 and CA311834.1. Transcript Variant: This variant uses an alternate splice site at the 3' end of the first exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: ERR279863.1013.1, SRR1163657.406426.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCG CGACGTTGAC TTCGAAATTG TACTCCCTGC TGTTCCGCAG GACCTCCACC 
TTCGCCCTCA CCATCATCGT GGGCGTCATG TTCTTCGAGC GCGCCTTCGA TCAAGGCGCG 
GACGCTATCT ACGACCACAT CAACGAGGGG GTGAGGGCCT GTGCCATCCC TGACCTTGGA 
CCCGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003684.1
CDS	31..219
Translation	MAAATLTSKLYSLLFRRTSTFALTIIVGVMFFERAFDQGADAIYDHINEGVRACAIPDLGPA

Target ORF information:

RefSeq Version	NM_001003684.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquinol-cytochrome c reductase, complex III subunit X (UQCR10), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003684.1

ORF Insert Sequence:

ATGGCGGCCG CGACGTTGAC TTCGAAATTG TACTCCCTGC TGTTCCGCAG GACCTCCACC 
TTCGCCCTCA CCATCATCGT GGGCGTCATG TTCTTCGAGC GCGCCTTCGA TCAAGGCGCG 
GACGCTATCT ACGACCACAT CAACGAGGGG GTGAGGGCCT GTGCCATCCC TGACCTTGGA 
CCCGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel fusion genes and chimeric transcripts in ependymal tumors.
Genes, chromosomes & cancer55(12)944-953(2016 Dec)
Olsen TK,Panagopoulos I,Gorunova L,Micci F,Andersen K,Kilen Andersen H,Meling TR,Due-T?nnessen B,Scheie D,Heim S,Brandal P

Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing.
Science translational medicine4(118)118ra10(2012 Jan)
Calvo SE,Compton AG,Hershman SG,Lim SC,Lieber DS,Tucker EJ,Laskowski A,Garone C,Liu S,Jaffe DB,Christodoulou J,Fletcher JM,Bruno DL,Goldblatt J,Dimauro S,Thorburn DR,Mootha VK

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.
Cell metabolism1(6)401-8(2005 Jun)
Guzy RD,Hoyos B,Robin E,Chen H,Liu L,Mansfield KD,Simon MC,Hammerling U,Schumacker PT

Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants.
Molecular vision8171-84(2002 Jun)
Wistow G,Bernstein SL,Wyatt MK,Behal A,Touchman JW,Bouffard G,Smith D,Peterson K

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UQCR10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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