GSTT2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GSTT2
Entrez Gene ID	2953
Full Name	glutathione S-transferase theta 2 (gene/pseudogene)
General protein information	Preferred Names glutathione S-transferase theta 2 (gene/pseudogene) Names glutathione S-transferase theta-2 GST class-theta-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q11.23
Summary	The protein encoded by this gene, glutathione S-transferase (GST) theta 2 (GSTT2), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015].
Disorder MIM:	600437

mRNA and Protein(s)

mRNA	Protein	Name
NM_001302670.1	NP_001289599.1	glutathione S-transferase theta-2 isoform b
NM_000854.4	NP_000845.2	glutathione S-transferase theta-2 isoform a

Pathways from BioSystems

Homologies

Homo sapiens (human)	GSTT2	NP_000845.1
	GSTT2	XP_001088025.1
Canis lupus familiaris (dog)	LOC100686488	XP_003433484.1
Homo sapiens (human)	GSTT2B	NP_001074312.1
Pan troglodytes (chimpanzee)	GSTT2	XP_515243.2
Mus musculus (house mouse)	Gstt2	NP_034491.2
Rattus norvegicus (Norway rat)	Gstt2	NP_036928.1

Gene Ontology
Bibliography

Related articles in PubMed

Glutathione S-transferase copy number variation alters lung gene expression.
Butler MW, Hackett NR, Salit J, Strulovici-Barel Y, Omberg L, Mezey J, Crystal RG
The European respiratory journal38(1)15-28(2011 Jul)

Impact of polyphenol metabolites produced by colonic microbiota on expression of COX-2 and GSTT2 in human colon cells (LT97).
Miene C, Weise A, Glei M
Nutrition and cancer63(4)653-62(2011)

Alcohol, tobacco and genetic susceptibility in relation to cancers of the upper aerodigestive tract in northern Italy.
Canova C, Richiardi L, Merletti F, Pentenero M, Gervasio C, Tanturri G, Garzino-Demo P, Pecorari G, Talamini R, Barzan L, Sulfaro S, Franchini G, Muzzolini C, Bordin S, Pugliese GN, Macr? E, Simonato L
Tumori96(1)1-10(2010 Jan-Feb)

Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione-S transferase (GST) genes.
Zhao Y, Marotta M, Eichler EE, Eng C, Tanaka H
PLoS genetics5(5)e1000472(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

analysis of glutathione S-transferase copy number variation alters lung gene expression
Title: Glutathione S-transferase copy number variation alters lung gene expression.

Polyphenol metabolites did not affect cell number but significantly upregulated GSTT2 expression and decreased COX-2.
Title: Impact of polyphenol metabolites produced by colonic microbiota on expression of COX-2 and GSTT2 in human colon cells (LT97).

Observational study of gene-disease association. (HuGE Navigator)
Title: Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Alcohol, tobacco and genetic susceptibility in relation to cancers of the upper aerodigestive tract in northern Italy.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Effect of gene-environment Interactions on mental development in African American, Dominican, and Caucasian mothers and newborns.

The following GSTT2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GSTT2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu58143	NM_000854.4 Latest version!	Homo sapiens glutathione S-transferase theta 2 (gene/pseudogene) (GSTT2), transcript variant 1, coding, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu54817	NM_001302670.1 Latest version!	Homo sapiens glutathione S-transferase theta 2 (gene/pseudogene) (GSTT2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GSTT2 ( NM_000854.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000845.2 Homo sapiens glutathione S-transferase theta 2 (gene/pseudogene) (GSTT2), transcript variant 1, coding, mRNA.

Price & Availability↑

CloneID	OHu58143
Clone ID Related Accession (Same CDS sequence)	NM_000854.4
Accession Version	NM_000854.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	glutathione S-transferase theta-2 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM804805.1, BU584249.1, CX782167.1, HY221848.1 and AA682380.1. On Nov 4, 2014 this sequence version replaced NM_000854.3. Transcript Variant: This variant (1, coding) encodes the longer isoform (a). This variant represents the ALT_REF_LOCI_1 alternate haplotype in the GRCh38 reference genome assembly. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 19424424 RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCCTAG AGCTGTTTCT TGACCTGGTG TCCCAGCCCA GCCGCGCCGT CTACATCTTC 
GCCAAGAAGA ATGGCATCCC CTTAGAGCTG CGCACCGTGG ATTTGGTCAA AGGGCAGCAC 
AAGAGCAAGG AGTTCTTGCA GATCAACAGC CTGGGGAAAC TGCCGACGCT CAAGGATGGT 
GATTTCATCT TGACCGAAAG CTCGGCCATC CTGATTTACC TGAGCTGTAA GTACCAGACG 
CCGGACCACT GGTATCCATC TGACCTGCAG GCTCGTGCCC GTGTTCATGA GTACCTGGGC 
TGGCATGCCG ACTGCATCCG TGGCACCTTT GGTATACCCC TGTGGGTCCA GGTGTTGGGG 
CCACTCATTG GGGTCCAGGT GCCCAAGGAG AAGGTGGAAC GCAACAGGAC TGCCATGGAC 
CAGGCCCTGC AATGGCTGGA GGACAAGTTC CTGGGGGACA GGCCCTTCCT CGCTGGCCAG 
CAGGTGACAC TGGCTGATCT CATGGCCCTG GAGGAGCTGA TGCAGCCGGT GGCTCTCGGC 
TATGAACTGT TTGAGGGACG GCCACGACTG GCAGCATGGC GTGGACGAGT GGAGGCTTTC 
CTGGGTGCTG AGCTATGCCA GGAGGCCCAC AGCATCATCT TGAGCATCCT GGAACAGGCG 
GCCAAGAAAA CCCTCCCAAC ACCCTCACCA GAGGCCTATC AGGCTATGCT GCTTCGAATC 
GCCAGGATCC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000845.2
CDS	171..905
Translation	MGLELFLDLVSQPSRAVYIFAKKNGIPLELRTVDLVKGQHKSKEFLQINSLGKLPTLKDGDFILTESSAILIYLSCKYQTPDHWYPSDLQARARVHEYLGWHADCIRGTFGIPLWVQVLGPLIGVQVPKEKVERNRTAMDQALQWLEDKFLGDRPFLAGQQVTLADLMALEELMQPVALGYELFEGRPRLAAWRGRVEAFLGAELCQEAHSIILSILEQAAKKTLPTPSPEAYQAMLLRIARIP

Target ORF information:

RefSeq Version	NM_000854.4
Organism	Homo sapiens(human)
Definition	Homo sapiens glutathione S-transferase theta 2 (gene/pseudogene) (GSTT2), transcript variant 1, coding, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000854.4

ORF Insert Sequence:

ATGGGCCTAG AGCTGTTTCT TGACCTGGTG TCCCAGCCCA GCCGCGCCGT CTACATCTTC 
GCCAAGAAGA ATGGCATCCC CTTAGAGCTG CGCACCGTGG ATTTGGTCAA AGGGCAGCAC 
AAGAGCAAGG AGTTCTTGCA GATCAACAGC CTGGGGAAAC TGCCGACGCT CAAGGATGGT 
GATTTCATCT TGACCGAAAG CTCGGCCATC CTGATTTACC TGAGCTGTAA GTACCAGACG 
CCGGACCACT GGTATCCATC TGACCTGCAG GCTCGTGCCC GTGTTCATGA GTACCTGGGC 
TGGCATGCCG ACTGCATCCG TGGCACCTTT GGTATACCCC TGTGGGTCCA GGTGTTGGGG 
CCACTCATTG GGGTCCAGGT GCCCAAGGAG AAGGTGGAAC GCAACAGGAC TGCCATGGAC 
CAGGCCCTGC AATGGCTGGA GGACAAGTTC CTGGGGGACA GGCCCTTCCT CGCTGGCCAG 
CAGGTGACAC TGGCTGATCT CATGGCCCTG GAGGAGCTGA TGCAGCCGGT GGCTCTCGGC 
TATGAACTGT TTGAGGGACG GCCACGACTG GCAGCATGGC GTGGACGAGT GGAGGCTTTC 
CTGGGTGCTG AGCTATGCCA GGAGGCCCAC AGCATCATCT TGAGCATCCT GGAACAGGCG 
GCCAAGAAAA CCCTCCCAAC ACCCTCACCA GAGGCCTATC AGGCTATGCT GCTTCGAATC 
GCCAGGATCC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GSTT2 ( NM_001302670.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289599.1 Homo sapiens glutathione S-transferase theta 2 (gene/pseudogene) (GSTT2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu54817
Clone ID Related Accession (Same CDS sequence)	NM_001302670.1
Accession Version	NM_001302670.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	glutathione S-transferase theta-2 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM804805.1, BU584249.1, CX782167.1, BM976631.1 and AA682380.1. On Nov 4, 2014 this sequence version replaced XM_005261590.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. This variant represents the ALT_REF_LOCI_1 alternate haplotype in the GRCh38 reference genome assembly. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 19424424 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCCTAG AGCTGTTTCT TGACCTGGTG TCCCAGCCCA GCCGCGCCGT CTACATCTTC 
GCCAAGAAGA ATGGCATCCC CTTAGAGCTG CGCACCGTGG ATTTGGTCAA AGGGCAGCAC 
AAGAGCAAGG AGTTCTTGCA GATCAACAGC CTGGGGAAAC TGCCGACGCT CAAGGATGGT 
GATTTCATCT TGACCGAAAG CTCGGCCATC CTGATTTACC TGAGCTGTAA GTACCAGACG 
CCGGACCACT GGTATCCATC TGACCTGCAG GCTCGTGCCC GTGTTCATGA GTACCTGGGC 
TGGCATGCCG ACTGCATCCG TGGCACCTTT GGTATACCCC TGTGGGTCCA GGTGTTGGGG 
CCACTCATTG GGGTCCAGGT GCCCAAGGAG AAGGTGGAAC GCAACAGGAC TGCCATGGAC 
CAGGCCCTGC AATGGCTGGA GGACAAGTTC CTGGGGGACA GGCCCTTCCT CGCTGGCCAG 
CAGCCGGTGG CTCTCGGCTA TGAACTGTTT GAGGGACGGC CACGACTGGC AGCATGGCGT 
GGACGAGTGG AGGCTTTCCT GGGTGCTGAG CTATGCCAGG AGGCCCACAG CATCATCTTG 
AGCATCCTGG AACAGGCGGC CAAGAAAACC CTCCCAACAC CCTCACCAGA GGCCTATCAG 
GCTATGCTGC TTCGAATCGC CAGGATCCCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289599.1
CDS	171..863
Translation	MGLELFLDLVSQPSRAVYIFAKKNGIPLELRTVDLVKGQHKSKEFLQINSLGKLPTLKDGDFILTESSAILIYLSCKYQTPDHWYPSDLQARARVHEYLGWHADCIRGTFGIPLWVQVLGPLIGVQVPKEKVERNRTAMDQALQWLEDKFLGDRPFLAGQQPVALGYELFEGRPRLAAWRGRVEAFLGAELCQEAHSIILSILEQAAKKTLPTPSPEAYQAMLLRIARIP

Target ORF information:

RefSeq Version	NM_001302670.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glutathione S-transferase theta 2 (gene/pseudogene) (GSTT2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302670.1

ORF Insert Sequence:

ATGGGCCTAG AGCTGTTTCT TGACCTGGTG TCCCAGCCCA GCCGCGCCGT CTACATCTTC 
GCCAAGAAGA ATGGCATCCC CTTAGAGCTG CGCACCGTGG ATTTGGTCAA AGGGCAGCAC 
AAGAGCAAGG AGTTCTTGCA GATCAACAGC CTGGGGAAAC TGCCGACGCT CAAGGATGGT 
GATTTCATCT TGACCGAAAG CTCGGCCATC CTGATTTACC TGAGCTGTAA GTACCAGACG 
CCGGACCACT GGTATCCATC TGACCTGCAG GCTCGTGCCC GTGTTCATGA GTACCTGGGC 
TGGCATGCCG ACTGCATCCG TGGCACCTTT GGTATACCCC TGTGGGTCCA GGTGTTGGGG 
CCACTCATTG GGGTCCAGGT GCCCAAGGAG AAGGTGGAAC GCAACAGGAC TGCCATGGAC 
CAGGCCCTGC AATGGCTGGA GGACAAGTTC CTGGGGGACA GGCCCTTCCT CGCTGGCCAG 
CAGCCGGTGG CTCTCGGCTA TGAACTGTTT GAGGGACGGC CACGACTGGC AGCATGGCGT 
GGACGAGTGG AGGCTTTCCT GGGTGCTGAG CTATGCCAGG AGGCCCACAG CATCATCTTG 
AGCATCCTGG AACAGGCGGC CAAGAAAACC CTCCCAACAC CCTCACCAGA GGCCTATCAG 
GCTATGCTGC TTCGAATCGC CAGGATCCCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glutathione S-transferase copy number variation alters lung gene expression.
The European respiratory journal38(1)15-28(2011 Jul)
Butler MW,Hackett NR,Salit J,Strulovici-Barel Y,Omberg L,Mezey J,Crystal RG

Impact of polyphenol metabolites produced by colonic microbiota on expression of COX-2 and GSTT2 in human colon cells (LT97).
Nutrition and cancer63(4)653-62(2011)
Miene C,Weise A,Glei M

Alcohol, tobacco and genetic susceptibility in relation to cancers of the upper aerodigestive tract in northern Italy.
Tumori96(1)1-10(2010 Jan-Feb)
Canova C,Richiardi L,Merletti F,Pentenero M,Gervasio C,Tanturri G,Garzino-Demo P,Pecorari G,Talamini R,Barzan L,Sulfaro S,Franchini G,Muzzolini C,Bordin S,Pugliese GN,Macr? E,Simonato L

Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione-S transferase (GST) genes.
PLoS genetics5(5)e1000472(2009 May)
Zhao Y,Marotta M,Eichler EE,Eng C,Tanaka H