GSR cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GSR
Entrez Gene ID	2936
Full Name	glutathione-disulfide reductase
Synonyms	HEL-75,HEL-S-122m
General protein information	Preferred Names glutathione-disulfide reductase Names glutathione reductase, mitochondrial GR GRase epididymis luminal protein 75 epididymis secretory sperm binding protein Li 122m glutathione S-reductase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p12
Summary	This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010].
Disorder MIM:	138300
Disorder Html:	Hemolytic anemia due to glutathione reductase deficiency (1)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001195102.2	NP_001182031.1	glutathione reductase, mitochondrial isoform 2
NM_001195103.2	NP_001182032.1	glutathione reductase, mitochondrial isoform 3
NM_000637.4	NP_000628.2	glutathione reductase, mitochondrial isoform 1 precursor
NM_000637.5	NP_000628.2	glutathione reductase, mitochondrial isoform 1 precursor
NM_000637.3	NP_000628.2	glutathione reductase, mitochondrial isoform 1 precursor
NM_001195104.2	NP_001182033.1	glutathione reductase, mitochondrial isoform 4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GSR	XP_519696.2
Canis lupus familiaris (dog)	GSR	XP_532813.2
Danio rerio (zebrafish)	gsr	NP_001018390.1
Eremothecium gossypii	AGOS_AGR196W	NP_986862.1
Oryza sativa (rice)	Os03g0163300	NP_001049057.1
Homo sapiens (human)	GSR	NP_000628.2
Mus musculus (house mouse)	Gsr	NP_034474.4
Schizosaccharomyces pombe (fission yeast)	pgr1	NP_595589.1
Neurospora crassa	NCU03339	XP_956448.1
Rattus norvegicus (Norway rat)	Gsr	NP_446358.2
Saccharomyces cerevisiae (baker's yeast)	GLR1	NP_015234.1
Kluyveromyces lactis	KLLA0E24069g	XP_455036.1
Xenopus tropicalis (tropical clawed frog)	gsr	NP_001120626.2
Bos taurus (cattle)	GSR	NP_001107662.1
Gallus gallus (chicken)	GSR	XP_001235017.2
Caenorhabditis elegans (roundworm)	gsr-1	NP_001021220.1
Magnaporthe oryzae (rice blast fungus)	MGG_12749	XP_003716743.1
Arabidopsis thaliana (thale cress)	GR	NP_191026.1

Gene Ontology
Bibliography

Related articles in PubMed

Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis.
Zhu Z, Du S, Du Y, Ren J, Ying G, Yan Z
Journal of neurochemistry144(1)93-104(2018 Jan)

Effect of exercise intensity on Nrf2 signalling in young men.
Done AJ, Newell MJ, Traustad?ttir T
Free radical research51(6)646-655(2017 Jun)

Plasma glutathione reductase activity and?prognosis of septic shock.
Kim JS, Kwon WY, Suh GJ, Kim KS, Jung YS, Kim SH, Lee SE
The Journal of surgical research200(1)298-307(2016 Jan)

[MODERN METHODS OF PROGNOSTICATION OF THE RECURRENCES OCCURRENCE AFTER SURGICAL TREATMENT OF THE MAMMARY GLAND BENIGN TUMORS].
Usenko OY, Romak RP
Klinichna khirurhiia(5)58-60(2015 May)

Reduction of mitochondrial protein mitoNEET [2Fe-2S] clusters by human glutathione reductase.
Landry AP, Cheng Z, Ding H
Free radical biology & medicine81119-27(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GSR expression was higher in TMZ-resistant cells than in sensitive cells. GSR silencing in drug-resistant cells improved the sensitivity of cells to TMZ or cisplatin. Over-expression resulted in resistance. GSR partially prevented the oxidative stress caused by L-buthionine -sulfoximine. The action of GSR in drug resistance is associated with the modulation of redox homeostasis. High GSR correlated with lower survival.
Title: Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis.

Plasma glutathione reductase (GR) activity was correlated with erythrocyte GR activity and the erythrocyte reduced glutathione/glutathione disulfide ratio. A decrease in plasma GR activity was associated with an increase in mortality in septic shock.
Title: Plasma glutathione reductase activity and?prognosis of septic shock.

The recurrence of benign tumors of mammary gland occurred predominantly in women-carriers of mutant alleles with polymorphism rs8190924 of gene GSR and AA rs3763511of gene DKK4.
Title: [MODERN METHODS OF PROGNOSTICATION OF THE RECURRENCES OCCURRENCE AFTER SURGICAL TREATMENT OF THE MAMMARY GLAND BENIGN TUMORS].

Glutathione reductase reduces mitochondrial protein mitoNEET [2Fe-2S] clusters.
Title: Reduction of mitochondrial protein mitoNEET [2Fe-2S] clusters by human glutathione reductase.

1,25 (OH) vitamin D significantly upregulated expression of GCLC and GR and lowered secretion of IL-8 and MCP-1 in high-glucose exposed U937 monocytes.
Title: Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes.

The following GSR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GSR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22860	NM_000637.5 Latest version!	Homo sapiens glutathione-disulfide reductase (GSR), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu08345	NM_001195102.2 Latest version!	Homo sapiens glutathione-disulfide reductase (GSR), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu08490	NM_001195103.2 Latest version!	Homo sapiens glutathione-disulfide reductase (GSR), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu08622	NM_001195104.2 Latest version!	Homo sapiens glutathione-disulfide reductase (GSR), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
View Old Accession Versions >>
OHu22860	NM_000637.4	Homo sapiens glutathione-disulfide reductase (GSR), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu22860	NM_000637.3	Homo sapiens glutathione reductase (GSR), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GSR ( NM_000637.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000628.2 Homo sapiens glutathione-disulfide reductase (GSR), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22860
Clone ID Related Accession (Same CDS sequence)	NM_000637.4 , NM_000637.5 , NM_000637.3
Accession Version	NM_000637.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1569bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	glutathione reductase, mitochondrial isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB988964.1, BC069244.1, AC103959.18 and CA944703.1. This sequence is a reference standard in the RefSeqGene project. On May 5, 2017 this sequence version replaced NM_000637.3. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.23701.1, SRR1660803.173373.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 10708558; reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCCCTGC TGCCCCGAGC CCTGAGCGCC GGCGCGGGAC CGAGCTGGCG GCGGGCGGCG 
CGCGCCTTCC GAGGCTTCCT GCTGCTTCTG CCCGAGCCCG CGGCCCTCAC GCGCGCCCTC 
TCCCGTGCCA TGGCCTGCAG GCAGGAGCCG CAGCCGCAGG GCCCGCCGCC CGCTGCTGGC 
GCCGTGGCCT CCTATGACTA CCTGGTGATC GGGGGCGGCT CGGGCGGGCT GGCCAGCGCG 
CGCAGGGCGG CCGAGCTGGG TGCCAGGGCC GCCGTGGTGG AGAGCCACAA GCTGGGTGGC 
ACTTGCGTGA ATGTTGGATG TGTACCCAAA AAGGTAATGT GGAACACAGC TGTCCACTCT 
GAATTCATGC ATGATCATGC TGATTATGGC TTTCCAAGTT GTGAGGGTAA ATTCAATTGG 
CGTGTTATTA AGGAAAAGCG GGATGCCTAT GTGAGCCGCC TGAATGCCAT CTATCAAAAC 
AATCTCACCA AGTCCCATAT AGAAATCATC CGTGGCCATG CAGCCTTCAC GAGTGATCCC 
AAGCCCACAA TAGAGGTCAG TGGGAAAAAG TACACCGCCC CACACATCCT GATCGCCACA 
GGTGGTATGC CCTCCACCCC TCATGAGAGC CAGATCCCCG GTGCCAGCTT AGGAATAACC 
AGCGATGGAT TTTTTCAGCT GGAAGAATTG CCCGGCCGCA GCGTCATTGT TGGTGCAGGT 
TACATTGCTG TGGAGATGGC AGGGATCCTG TCAGCCCTGG GTTCTAAGAC ATCACTGATG 
ATACGGCATG ATAAGGTACT TAGAAGTTTT GATTCAATGA TCAGCACCAA CTGCACGGAG 
GAGCTGGAGA ACGCTGGCGT GGAGGTGCTG AAGTTCTCCC AGGTCAAGGA GGTTAAAAAG 
ACTTTGTCGG GCTTGGAAGT CAGCATGGTT ACTGCAGTTC CCGGTAGGCT ACCAGTCATG 
ACCATGATTC CAGATGTTGA CTGCCTGCTC TGGGCCATTG GGCGGGTCCC GAATACCAAG 
GACCTGAGTT TAAACAAACT GGGGATTCAA ACCGATGACA AGGGTCATAT CATCGTAGAC 
GAATTCCAGA ATACCAACGT CAAAGGCATC TATGCAGTTG GGGATGTATG TGGAAAAGCT 
CTTCTTACTC CAGTTGCAAT AGCTGCTGGC CGAAAACTTG CCCATCGACT TTTTGAATAT 
AAGGAAGATT CCAAATTAGA TTATAACAAC ATCCCAACTG TGGTCTTCAG CCACCCCCCT 
ATTGGGACAG TGGGACTCAC GGAAGATGAA GCCATTCATA AATATGGAAT AGAAAATGTG 
AAGACCTATT CAACGAGCTT TACCCCGATG TATCACGCAG TTACCAAAAG GAAAACAAAA 
TGTGTGATGA AAATGGTCTG TGCTAACAAG GAAGAAAAGG TGGTTGGGAT CCATATGCAG 
GGACTTGGGT GTGATGAAAT GCTGCAGGGT TTTGCTGTTG CAGTGAAGAT GGGAGCAACG 
AAGGCAGACT TTGACAACAC AGTCGCCATT CACCCTACCT CTTCAGAAGA GCTGGTCACA 
CTTCGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000628.2
CDS	165..1733
Translation	MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR

Target ORF information:

RefSeq Version	NM_000637.4
Organism	Homo sapiens(human)
Definition	Homo sapiens glutathione-disulfide reductase (GSR), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000637.4

ORF Insert Sequence:

ATGGCCCTGC TGCCCCGAGC CCTGAGCGCC GGCGCGGGAC CGAGCTGGCG GCGGGCGGCG 
CGCGCCTTCC GAGGCTTCCT GCTGCTTCTG CCCGAGCCCG CGGCCCTCAC GCGCGCCCTC 
TCCCGTGCCA TGGCCTGCAG GCAGGAGCCG CAGCCGCAGG GCCCGCCGCC CGCTGCTGGC 
GCCGTGGCCT CCTATGACTA CCTGGTGATC GGGGGCGGCT CGGGCGGGCT GGCCAGCGCG 
CGCAGGGCGG CCGAGCTGGG TGCCAGGGCC GCCGTGGTGG AGAGCCACAA GCTGGGTGGC 
ACTTGCGTGA ATGTTGGATG TGTACCCAAA AAGGTAATGT GGAACACAGC TGTCCACTCT 
GAATTCATGC ATGATCATGC TGATTATGGC TTTCCAAGTT GTGAGGGTAA ATTCAATTGG 
CGTGTTATTA AGGAAAAGCG GGATGCCTAT GTGAGCCGCC TGAATGCCAT CTATCAAAAC 
AATCTCACCA AGTCCCATAT AGAAATCATC CGTGGCCATG CAGCCTTCAC GAGTGATCCC 
AAGCCCACAA TAGAGGTCAG TGGGAAAAAG TACACCGCCC CACACATCCT GATCGCCACA 
GGTGGTATGC CCTCCACCCC TCATGAGAGC CAGATCCCCG GTGCCAGCTT AGGAATAACC 
AGCGATGGAT TTTTTCAGCT GGAAGAATTG CCCGGCCGCA GCGTCATTGT TGGTGCAGGT 
TACATTGCTG TGGAGATGGC AGGGATCCTG TCAGCCCTGG GTTCTAAGAC ATCACTGATG 
ATACGGCATG ATAAGGTACT TAGAAGTTTT GATTCAATGA TCAGCACCAA CTGCACGGAG 
GAGCTGGAGA ACGCTGGCGT GGAGGTGCTG AAGTTCTCCC AGGTCAAGGA GGTTAAAAAG 
ACTTTGTCGG GCTTGGAAGT CAGCATGGTT ACTGCAGTTC CCGGTAGGCT ACCAGTCATG 
ACCATGATTC CAGATGTTGA CTGCCTGCTC TGGGCCATTG GGCGGGTCCC GAATACCAAG 
GACCTGAGTT TAAACAAACT GGGGATTCAA ACCGATGACA AGGGTCATAT CATCGTAGAC 
GAATTCCAGA ATACCAACGT CAAAGGCATC TATGCAGTTG GGGATGTATG TGGAAAAGCT 
CTTCTTACTC CAGTTGCAAT AGCTGCTGGC CGAAAACTTG CCCATCGACT TTTTGAATAT 
AAGGAAGATT CCAAATTAGA TTATAACAAC ATCCCAACTG TGGTCTTCAG CCACCCCCCT 
ATTGGGACAG TGGGACTCAC GGAAGATGAA GCCATTCATA AATATGGAAT AGAAAATGTG 
AAGACCTATT CAACGAGCTT TACCCCGATG TATCACGCAG TTACCAAAAG GAAAACAAAA 
TGTGTGATGA AAATGGTCTG TGCTAACAAG GAAGAAAAGG TGGTTGGGAT CCATATGCAG 
GGACTTGGGT GTGATGAAAT GCTGCAGGGT TTTGCTGTTG CAGTGAAGAT GGGAGCAACG 
AAGGCAGACT TTGACAACAC AGTCGCCATT CACCCTACCT CTTCAGAAGA GCTGGTCACA 
CTTCGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GSR ( NM_000637.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000628.2 Homo sapiens glutathione-disulfide reductase (GSR), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22860
Clone ID Related Accession (Same CDS sequence)	NM_000637.4 , NM_000637.5 , NM_000637.3
Accession Version	NM_000637.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1569bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-29
Organism	Homo sapiens(human)
Product	glutathione reductase, mitochondrial isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069244.1, AC103959.18 and CA944703.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_000637.4. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035691.1, SRR1163655.23701.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 10708558; reported by MitoCarta MANE Ensembl match :: ENST00000221130.11/ ENSP00000221130.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCTGC TGCCCCGAGC CCTGAGCGCC GGCGCGGGAC CGAGCTGGCG GCGGGCGGCG 
CGCGCCTTCC GAGGCTTCCT GCTGCTTCTG CCCGAGCCCG CGGCCCTCAC GCGCGCCCTC 
TCCCGTGCCA TGGCCTGCAG GCAGGAGCCG CAGCCGCAGG GCCCGCCGCC CGCTGCTGGC 
GCCGTGGCCT CCTATGACTA CCTGGTGATC GGGGGCGGCT CGGGCGGGCT GGCCAGCGCG 
CGCAGGGCGG CCGAGCTGGG TGCCAGGGCC GCCGTGGTGG AGAGCCACAA GCTGGGTGGC 
ACTTGCGTGA ATGTTGGATG TGTACCCAAA AAGGTAATGT GGAACACAGC TGTCCACTCT 
GAATTCATGC ATGATCATGC TGATTATGGC TTTCCAAGTT GTGAGGGTAA ATTCAATTGG 
CGTGTTATTA AGGAAAAGCG GGATGCCTAT GTGAGCCGCC TGAATGCCAT CTATCAAAAC 
AATCTCACCA AGTCCCATAT AGAAATCATC CGTGGCCATG CAGCCTTCAC GAGTGATCCC 
AAGCCCACAA TAGAGGTCAG TGGGAAAAAG TACACCGCCC CACACATCCT GATCGCCACA 
GGTGGTATGC CCTCCACCCC TCATGAGAGC CAGATCCCCG GTGCCAGCTT AGGAATAACC 
AGCGATGGAT TTTTTCAGCT GGAAGAATTG CCCGGCCGCA GCGTCATTGT TGGTGCAGGT 
TACATTGCTG TGGAGATGGC AGGGATCCTG TCAGCCCTGG GTTCTAAGAC ATCACTGATG 
ATACGGCATG ATAAGGTACT TAGAAGTTTT GATTCAATGA TCAGCACCAA CTGCACGGAG 
GAGCTGGAGA ACGCTGGCGT GGAGGTGCTG AAGTTCTCCC AGGTCAAGGA GGTTAAAAAG 
ACTTTGTCGG GCTTGGAAGT CAGCATGGTT ACTGCAGTTC CCGGTAGGCT ACCAGTCATG 
ACCATGATTC CAGATGTTGA CTGCCTGCTC TGGGCCATTG GGCGGGTCCC GAATACCAAG 
GACCTGAGTT TAAACAAACT GGGGATTCAA ACCGATGACA AGGGTCATAT CATCGTAGAC 
GAATTCCAGA ATACCAACGT CAAAGGCATC TATGCAGTTG GGGATGTATG TGGAAAAGCT 
CTTCTTACTC CAGTTGCAAT AGCTGCTGGC CGAAAACTTG CCCATCGACT TTTTGAATAT 
AAGGAAGATT CCAAATTAGA TTATAACAAC ATCCCAACTG TGGTCTTCAG CCACCCCCCT 
ATTGGGACAG TGGGACTCAC GGAAGATGAA GCCATTCATA AATATGGAAT AGAAAATGTG 
AAGACCTATT CAACGAGCTT TACCCCGATG TATCACGCAG TTACCAAAAG GAAAACAAAA 
TGTGTGATGA AAATGGTCTG TGCTAACAAG GAAGAAAAGG TGGTTGGGAT CCATATGCAG 
GGACTTGGGT GTGATGAAAT GCTGCAGGGT TTTGCTGTTG CAGTGAAGAT GGGAGCAACG 
AAGGCAGACT TTGACAACAC AGTCGCCATT CACCCTACCT CTTCAGAAGA GCTGGTCACA 
CTTCGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000628.2
CDS	12..1580
Translation	MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR

Target ORF information:

RefSeq Version	NM_000637.5
Organism	Homo sapiens(human)
Definition	Homo sapiens glutathione-disulfide reductase (GSR), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000637.5

ORF Insert Sequence:

ATGGCCCTGC TGCCCCGAGC CCTGAGCGCC GGCGCGGGAC CGAGCTGGCG GCGGGCGGCG 
CGCGCCTTCC GAGGCTTCCT GCTGCTTCTG CCCGAGCCCG CGGCCCTCAC GCGCGCCCTC 
TCCCGTGCCA TGGCCTGCAG GCAGGAGCCG CAGCCGCAGG GCCCGCCGCC CGCTGCTGGC 
GCCGTGGCCT CCTATGACTA CCTGGTGATC GGGGGCGGCT CGGGCGGGCT GGCCAGCGCG 
CGCAGGGCGG CCGAGCTGGG TGCCAGGGCC GCCGTGGTGG AGAGCCACAA GCTGGGTGGC 
ACTTGCGTGA ATGTTGGATG TGTACCCAAA AAGGTAATGT GGAACACAGC TGTCCACTCT 
GAATTCATGC ATGATCATGC TGATTATGGC TTTCCAAGTT GTGAGGGTAA ATTCAATTGG 
CGTGTTATTA AGGAAAAGCG GGATGCCTAT GTGAGCCGCC TGAATGCCAT CTATCAAAAC 
AATCTCACCA AGTCCCATAT AGAAATCATC CGTGGCCATG CAGCCTTCAC GAGTGATCCC 
AAGCCCACAA TAGAGGTCAG TGGGAAAAAG TACACCGCCC CACACATCCT GATCGCCACA 
GGTGGTATGC CCTCCACCCC TCATGAGAGC CAGATCCCCG GTGCCAGCTT AGGAATAACC 
AGCGATGGAT TTTTTCAGCT GGAAGAATTG CCCGGCCGCA GCGTCATTGT TGGTGCAGGT 
TACATTGCTG TGGAGATGGC AGGGATCCTG TCAGCCCTGG GTTCTAAGAC ATCACTGATG 
ATACGGCATG ATAAGGTACT TAGAAGTTTT GATTCAATGA TCAGCACCAA CTGCACGGAG 
GAGCTGGAGA ACGCTGGCGT GGAGGTGCTG AAGTTCTCCC AGGTCAAGGA GGTTAAAAAG 
ACTTTGTCGG GCTTGGAAGT CAGCATGGTT ACTGCAGTTC CCGGTAGGCT ACCAGTCATG 
ACCATGATTC CAGATGTTGA CTGCCTGCTC TGGGCCATTG GGCGGGTCCC GAATACCAAG 
GACCTGAGTT TAAACAAACT GGGGATTCAA ACCGATGACA AGGGTCATAT CATCGTAGAC 
GAATTCCAGA ATACCAACGT CAAAGGCATC TATGCAGTTG GGGATGTATG TGGAAAAGCT 
CTTCTTACTC CAGTTGCAAT AGCTGCTGGC CGAAAACTTG CCCATCGACT TTTTGAATAT 
AAGGAAGATT CCAAATTAGA TTATAACAAC ATCCCAACTG TGGTCTTCAG CCACCCCCCT 
ATTGGGACAG TGGGACTCAC GGAAGATGAA GCCATTCATA AATATGGAAT AGAAAATGTG 
AAGACCTATT CAACGAGCTT TACCCCGATG TATCACGCAG TTACCAAAAG GAAAACAAAA 
TGTGTGATGA AAATGGTCTG TGCTAACAAG GAAGAAAAGG TGGTTGGGAT CCATATGCAG 
GGACTTGGGT GTGATGAAAT GCTGCAGGGT TTTGCTGTTG CAGTGAAGAT GGGAGCAACG 
AAGGCAGACT TTGACAACAC AGTCGCCATT CACCCTACCT CTTCAGAAGA GCTGGTCACA 
CTTCGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GSR ( NM_000637.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000628.2 Homo sapiens glutathione reductase (GSR), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22860
Clone ID Related Accession (Same CDS sequence)	NM_000637.4 , NM_000637.5 , NM_000637.3
Accession Version	NM_000637.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1569bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	glutathione reductase, mitochondrial isoform 1 precursor
Comment

ATGGCCCTGC TGCCCCGAGC CCTGAGCGCC GGCGCGGGAC CGAGCTGGCG GCGGGCGGCG 
CGCGCCTTCC GAGGCTTCCT GCTGCTTCTG CCCGAGCCCG CGGCCCTCAC GCGCGCCCTC 
TCCCGTGCCA TGGCCTGCAG GCAGGAGCCG CAGCCGCAGG GCCCGCCGCC CGCTGCTGGC 
GCCGTGGCCT CCTATGACTA CCTGGTGATC GGGGGCGGCT CGGGCGGGCT GGCCAGCGCG 
CGCAGGGCGG CCGAGCTGGG TGCCAGGGCC GCCGTGGTGG AGAGCCACAA GCTGGGTGGC 
ACTTGCGTGA ATGTTGGATG TGTACCCAAA AAGGTAATGT GGAACACAGC TGTCCACTCT 
GAATTCATGC ATGATCATGC TGATTATGGC TTTCCAAGTT GTGAGGGTAA ATTCAATTGG 
CGTGTTATTA AGGAAAAGCG GGATGCCTAT GTGAGCCGCC TGAATGCCAT CTATCAAAAC 
AATCTCACCA AGTCCCATAT AGAAATCATC CGTGGCCATG CAGCCTTCAC GAGTGATCCC 
AAGCCCACAA TAGAGGTCAG TGGGAAAAAG TACACCGCCC CACACATCCT GATCGCCACA 
GGTGGTATGC CCTCCACCCC TCATGAGAGC CAGATCCCCG GTGCCAGCTT AGGAATAACC 
AGCGATGGAT TTTTTCAGCT GGAAGAATTG CCCGGCCGCA GCGTCATTGT TGGTGCAGGT 
TACATTGCTG TGGAGATGGC AGGGATCCTG TCAGCCCTGG GTTCTAAGAC ATCACTGATG 
ATACGGCATG ATAAGGTACT TAGAAGTTTT GATTCAATGA TCAGCACCAA CTGCACGGAG 
GAGCTGGAGA ACGCTGGCGT GGAGGTGCTG AAGTTCTCCC AGGTCAAGGA GGTTAAAAAG 
ACTTTGTCGG GCTTGGAAGT CAGCATGGTT ACTGCAGTTC CCGGTAGGCT ACCAGTCATG 
ACCATGATTC CAGATGTTGA CTGCCTGCTC TGGGCCATTG GGCGGGTCCC GAATACCAAG 
GACCTGAGTT TAAACAAACT GGGGATTCAA ACCGATGACA AGGGTCATAT CATCGTAGAC 
GAATTCCAGA ATACCAACGT CAAAGGCATC TATGCAGTTG GGGATGTATG TGGAAAAGCT 
CTTCTTACTC CAGTTGCAAT AGCTGCTGGC CGAAAACTTG CCCATCGACT TTTTGAATAT 
AAGGAAGATT CCAAATTAGA TTATAACAAC ATCCCAACTG TGGTCTTCAG CCACCCCCCT 
ATTGGGACAG TGGGACTCAC GGAAGATGAA GCCATTCATA AATATGGAAT AGAAAATGTG 
AAGACCTATT CAACGAGCTT TACCCCGATG TATCACGCAG TTACCAAAAG GAAAACAAAA 
TGTGTGATGA AAATGGTCTG TGCTAACAAG GAAGAAAAGG TGGTTGGGAT CCATATGCAG 
GGACTTGGGT GTGATGAAAT GCTGCAGGGT TTTGCTGTTG CAGTGAAGAT GGGAGCAACG 
AAGGCAGACT TTGACAACAC AGTCGCCATT CACCCTACCT CTTCAGAAGA GCTGGTCACA 
CTTCGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_000628.2

Translation

MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR

Target ORF information:

RefSeq Version	NM_000637.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens glutathione reductase (GSR), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000637.3

ORF Insert Sequence:

ATGGCCCTGC TGCCCCGAGC CCTGAGCGCC GGCGCGGGAC CGAGCTGGCG GCGGGCGGCG 
CGCGCCTTCC GAGGCTTCCT GCTGCTTCTG CCCGAGCCCG CGGCCCTCAC GCGCGCCCTC 
TCCCGTGCCA TGGCCTGCAG GCAGGAGCCG CAGCCGCAGG GCCCGCCGCC CGCTGCTGGC 
GCCGTGGCCT CCTATGACTA CCTGGTGATC GGGGGCGGCT CGGGCGGGCT GGCCAGCGCG 
CGCAGGGCGG CCGAGCTGGG TGCCAGGGCC GCCGTGGTGG AGAGCCACAA GCTGGGTGGC 
ACTTGCGTGA ATGTTGGATG TGTACCCAAA AAGGTAATGT GGAACACAGC TGTCCACTCT 
GAATTCATGC ATGATCATGC TGATTATGGC TTTCCAAGTT GTGAGGGTAA ATTCAATTGG 
CGTGTTATTA AGGAAAAGCG GGATGCCTAT GTGAGCCGCC TGAATGCCAT CTATCAAAAC 
AATCTCACCA AGTCCCATAT AGAAATCATC CGTGGCCATG CAGCCTTCAC GAGTGATCCC 
AAGCCCACAA TAGAGGTCAG TGGGAAAAAG TACACCGCCC CACACATCCT GATCGCCACA 
GGTGGTATGC CCTCCACCCC TCATGAGAGC CAGATCCCCG GTGCCAGCTT AGGAATAACC 
AGCGATGGAT TTTTTCAGCT GGAAGAATTG CCCGGCCGCA GCGTCATTGT TGGTGCAGGT 
TACATTGCTG TGGAGATGGC AGGGATCCTG TCAGCCCTGG GTTCTAAGAC ATCACTGATG 
ATACGGCATG ATAAGGTACT TAGAAGTTTT GATTCAATGA TCAGCACCAA CTGCACGGAG 
GAGCTGGAGA ACGCTGGCGT GGAGGTGCTG AAGTTCTCCC AGGTCAAGGA GGTTAAAAAG 
ACTTTGTCGG GCTTGGAAGT CAGCATGGTT ACTGCAGTTC CCGGTAGGCT ACCAGTCATG 
ACCATGATTC CAGATGTTGA CTGCCTGCTC TGGGCCATTG GGCGGGTCCC GAATACCAAG 
GACCTGAGTT TAAACAAACT GGGGATTCAA ACCGATGACA AGGGTCATAT CATCGTAGAC 
GAATTCCAGA ATACCAACGT CAAAGGCATC TATGCAGTTG GGGATGTATG TGGAAAAGCT 
CTTCTTACTC CAGTTGCAAT AGCTGCTGGC CGAAAACTTG CCCATCGACT TTTTGAATAT 
AAGGAAGATT CCAAATTAGA TTATAACAAC ATCCCAACTG TGGTCTTCAG CCACCCCCCT 
ATTGGGACAG TGGGACTCAC GGAAGATGAA GCCATTCATA AATATGGAAT AGAAAATGTG 
AAGACCTATT CAACGAGCTT TACCCCGATG TATCACGCAG TTACCAAAAG GAAAACAAAA 
TGTGTGATGA AAATGGTCTG TGCTAACAAG GAAGAAAAGG TGGTTGGGAT CCATATGCAG 
GGACTTGGGT GTGATGAAAT GCTGCAGGGT TTTGCTGTTG CAGTGAAGAT GGGAGCAACG 
AAGGCAGACT TTGACAACAC AGTCGCCATT CACCCTACCT CTTCAGAAGA GCTGGTCACA 
CTTCGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GSR ( NM_001195102.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182031.1 Homo sapiens glutathione-disulfide reductase (GSR), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08345
Clone ID Related Accession (Same CDS sequence)	NM_001195102.2
Accession Version	NM_001195102.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-29
Organism	Homo sapiens(human)
Product	glutathione reductase, mitochondrial isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB988964.1, BM148117.1, AB519179.1, AC103959.18 and CA944703.1. On May 5, 2017 this sequence version replaced NM_001195102.1. Transcript Variant: This variant (2, also known as delta8) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.187480.1, AB519179.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 10708558; reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCCCTGC TGCCCCGAGC CCTGAGCGCC GGCGCGGGAC CGAGCTGGCG GCGGGCGGCG 
CGCGCCTTCC GAGGCTTCCT GCTGCTTCTG CCCGAGCCCG CGGCCCTCAC GCGCGCCCTC 
TCCCGTGCCA TGGCCTGCAG GCAGGAGCCG CAGCCGCAGG GCCCGCCGCC CGCTGCTGGC 
GCCGTGGCCT CCTATGACTA CCTGGTGATC GGGGGCGGCT CGGGCGGGCT GGCCAGCGCG 
CGCAGGGCGG CCGAGCTGGG TGCCAGGGCC GCCGTGGTGG AGAGCCACAA GCTGGGTGGC 
ACTTGCGTGA ATGTTGGATG TGTACCCAAA AAGGTAATGT GGAACACAGC TGTCCACTCT 
GAATTCATGC ATGATCATGC TGATTATGGC TTTCCAAGTT GTGAGGGTAA ATTCAATTGG 
CGTGTTATTA AGGAAAAGCG GGATGCCTAT GTGAGCCGCC TGAATGCCAT CTATCAAAAC 
AATCTCACCA AGTCCCATAT AGAAATCATC CGTGGCCATG CAGCCTTCAC GAGTGATCCC 
AAGCCCACAA TAGAGGTCAG TGGGAAAAAG TACACCGCCC CACACATCCT GATCGCCACA 
GGTGGTATGC CCTCCACCCC TCATGAGAGC CAGATCCCCG GTGCCAGCTT AGGAATAACC 
AGCGATGGAT TTTTTCAGCT GGAAGAATTG CCCGGCCGCA GCGTCATTGT TGGTGCAGGT 
TACATTGCTG TGGAGATGGC AGGGATCCTG TCAGCCCTGG GTTCTAAGAC ATCACTGATG 
ATACGGCATG ATAAGGTCAA GGAGGTTAAA AAGACTTTGT CGGGCTTGGA AGTCAGCATG 
GTTACTGCAG TTCCCGGTAG GCTACCAGTC ATGACCATGA TTCCAGATGT TGACTGCCTG 
CTCTGGGCCA TTGGGCGGGT CCCGAATACC AAGGACCTGA GTTTAAACAA ACTGGGGATT 
CAAACCGATG ACAAGGGTCA TATCATCGTA GACGAATTCC AGAATACCAA CGTCAAAGGC 
ATCTATGCAG TTGGGGATGT ATGTGGAAAA GCTCTTCTTA CTCCAGTTGC AATAGCTGCT 
GGCCGAAAAC TTGCCCATCG ACTTTTTGAA TATAAGGAAG ATTCCAAATT AGATTATAAC 
AACATCCCAA CTGTGGTCTT CAGCCACCCC CCTATTGGGA CAGTGGGACT CACGGAAGAT 
GAAGCCATTC ATAAATATGG AATAGAAAAT GTGAAGACCT ATTCAACGAG CTTTACCCCG 
ATGTATCACG CAGTTACCAA AAGGAAAACA AAATGTGTGA TGAAAATGGT CTGTGCTAAC 
AAGGAAGAAA AGGTGGTTGG GATCCATATG CAGGGACTTG GGTGTGATGA AATGCTGCAG 
GGTTTTGCTG TTGCAGTGAA GATGGGAGCA ACGAAGGCAG ACTTTGACAA CACAGTCGCC 
ATTCACCCTA CCTCTTCAGA AGAGCTGGTC ACACTTCGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182031.1
CDS	165..1646
Translation	MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR

Target ORF information:

RefSeq Version	NM_001195102.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glutathione-disulfide reductase (GSR), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195102.2

ORF Insert Sequence:

ATGGCCCTGC TGCCCCGAGC CCTGAGCGCC GGCGCGGGAC CGAGCTGGCG GCGGGCGGCG 
CGCGCCTTCC GAGGCTTCCT GCTGCTTCTG CCCGAGCCCG CGGCCCTCAC GCGCGCCCTC 
TCCCGTGCCA TGGCCTGCAG GCAGGAGCCG CAGCCGCAGG GCCCGCCGCC CGCTGCTGGC 
GCCGTGGCCT CCTATGACTA CCTGGTGATC GGGGGCGGCT CGGGCGGGCT GGCCAGCGCG 
CGCAGGGCGG CCGAGCTGGG TGCCAGGGCC GCCGTGGTGG AGAGCCACAA GCTGGGTGGC 
ACTTGCGTGA ATGTTGGATG TGTACCCAAA AAGGTAATGT GGAACACAGC TGTCCACTCT 
GAATTCATGC ATGATCATGC TGATTATGGC TTTCCAAGTT GTGAGGGTAA ATTCAATTGG 
CGTGTTATTA AGGAAAAGCG GGATGCCTAT GTGAGCCGCC TGAATGCCAT CTATCAAAAC 
AATCTCACCA AGTCCCATAT AGAAATCATC CGTGGCCATG CAGCCTTCAC GAGTGATCCC 
AAGCCCACAA TAGAGGTCAG TGGGAAAAAG TACACCGCCC CACACATCCT GATCGCCACA 
GGTGGTATGC CCTCCACCCC TCATGAGAGC CAGATCCCCG GTGCCAGCTT AGGAATAACC 
AGCGATGGAT TTTTTCAGCT GGAAGAATTG CCCGGCCGCA GCGTCATTGT TGGTGCAGGT 
TACATTGCTG TGGAGATGGC AGGGATCCTG TCAGCCCTGG GTTCTAAGAC ATCACTGATG 
ATACGGCATG ATAAGGTCAA GGAGGTTAAA AAGACTTTGT CGGGCTTGGA AGTCAGCATG 
GTTACTGCAG TTCCCGGTAG GCTACCAGTC ATGACCATGA TTCCAGATGT TGACTGCCTG 
CTCTGGGCCA TTGGGCGGGT CCCGAATACC AAGGACCTGA GTTTAAACAA ACTGGGGATT 
CAAACCGATG ACAAGGGTCA TATCATCGTA GACGAATTCC AGAATACCAA CGTCAAAGGC 
ATCTATGCAG TTGGGGATGT ATGTGGAAAA GCTCTTCTTA CTCCAGTTGC AATAGCTGCT 
GGCCGAAAAC TTGCCCATCG ACTTTTTGAA TATAAGGAAG ATTCCAAATT AGATTATAAC 
AACATCCCAA CTGTGGTCTT CAGCCACCCC CCTATTGGGA CAGTGGGACT CACGGAAGAT 
GAAGCCATTC ATAAATATGG AATAGAAAAT GTGAAGACCT ATTCAACGAG CTTTACCCCG 
ATGTATCACG CAGTTACCAA AAGGAAAACA AAATGTGTGA TGAAAATGGT CTGTGCTAAC 
AAGGAAGAAA AGGTGGTTGG GATCCATATG CAGGGACTTG GGTGTGATGA AATGCTGCAG 
GGTTTTGCTG TTGCAGTGAA GATGGGAGCA ACGAAGGCAG ACTTTGACAA CACAGTCGCC 
ATTCACCCTA CCTCTTCAGA AGAGCTGGTC ACACTTCGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GSR ( NM_001195103.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182032.1 Homo sapiens glutathione-disulfide reductase (GSR), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu08490
Clone ID Related Accession (Same CDS sequence)	NM_001195103.2
Accession Version	NM_001195103.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1410bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-29
Organism	Homo sapiens(human)
Product	glutathione reductase, mitochondrial isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB988964.1, BM148117.1, AB519180.1, AC103959.18 and CA944703.1. On May 5, 2017 this sequence version replaced NM_001195103.1. Transcript Variant: This variant (3, also known as delta9) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.258688.1, AB519180.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 10708558; reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCCCTGC TGCCCCGAGC CCTGAGCGCC GGCGCGGGAC CGAGCTGGCG GCGGGCGGCG 
CGCGCCTTCC GAGGCTTCCT GCTGCTTCTG CCCGAGCCCG CGGCCCTCAC GCGCGCCCTC 
TCCCGTGCCA TGGCCTGCAG GCAGGAGCCG CAGCCGCAGG GCCCGCCGCC CGCTGCTGGC 
GCCGTGGCCT CCTATGACTA CCTGGTGATC GGGGGCGGCT CGGGCGGGCT GGCCAGCGCG 
CGCAGGGCGG CCGAGCTGGG TGCCAGGGCC GCCGTGGTGG AGAGCCACAA GCTGGGTGGC 
ACTTGCGTGA ATGTTGGATG TGTACCCAAA AAGGTAATGT GGAACACAGC TGTCCACTCT 
GAATTCATGC ATGATCATGC TGATTATGGC TTTCCAAGTT GTGAGGGTAA ATTCAATTGG 
CGTGTTATTA AGGAAAAGCG GGATGCCTAT GTGAGCCGCC TGAATGCCAT CTATCAAAAC 
AATCTCACCA AGTCCCATAT AGAAATCATC CGTGGCCATG CAGCCTTCAC GAGTGATCCC 
AAGCCCACAA TAGAGGTCAG TGGGAAAAAG TACACCGCCC CACACATCCT GATCGCCACA 
GGTGGTATGC CCTCCACCCC TCATGAGAGC CAGATCCCCG GTGCCAGCTT AGGAATAACC 
AGCGATGGAT TTTTTCAGCT GGAAGAATTG CCCGGCCGCA GCGTCATTGT TGGTGCAGGT 
TACATTGCTG TGGAGATGGC AGGGATCCTG TCAGCCCTGG GTTCTAAGAC ATCACTGATG 
ATACGGCATG ATAAGGTACT TAGAAGTTTT GATTCAATGA TCAGCACCAA CTGCACGGAG 
GAGCTGGAGA ACGCTGGCGT GGAGGTGCTG AAGTTCTCCC AGGGGATTCA AACCGATGAC 
AAGGGTCATA TCATCGTAGA CGAATTCCAG AATACCAACG TCAAAGGCAT CTATGCAGTT 
GGGGATGTAT GTGGAAAAGC TCTTCTTACT CCAGTTGCAA TAGCTGCTGG CCGAAAACTT 
GCCCATCGAC TTTTTGAATA TAAGGAAGAT TCCAAATTAG ATTATAACAA CATCCCAACT 
GTGGTCTTCA GCCACCCCCC TATTGGGACA GTGGGACTCA CGGAAGATGA AGCCATTCAT 
AAATATGGAA TAGAAAATGT GAAGACCTAT TCAACGAGCT TTACCCCGAT GTATCACGCA 
GTTACCAAAA GGAAAACAAA ATGTGTGATG AAAATGGTCT GTGCTAACAA GGAAGAAAAG 
GTGGTTGGGA TCCATATGCA GGGACTTGGG TGTGATGAAA TGCTGCAGGG TTTTGCTGTT 
GCAGTGAAGA TGGGAGCAAC GAAGGCAGAC TTTGACAACA CAGTCGCCAT TCACCCTACC 
TCTTCAGAAG AGCTGGTCAC ACTTCGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182032.1
CDS	165..1574
Translation	MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR

Target ORF information:

RefSeq Version	NM_001195103.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glutathione-disulfide reductase (GSR), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195103.2

ORF Insert Sequence:

ATGGCCCTGC TGCCCCGAGC CCTGAGCGCC GGCGCGGGAC CGAGCTGGCG GCGGGCGGCG 
CGCGCCTTCC GAGGCTTCCT GCTGCTTCTG CCCGAGCCCG CGGCCCTCAC GCGCGCCCTC 
TCCCGTGCCA TGGCCTGCAG GCAGGAGCCG CAGCCGCAGG GCCCGCCGCC CGCTGCTGGC 
GCCGTGGCCT CCTATGACTA CCTGGTGATC GGGGGCGGCT CGGGCGGGCT GGCCAGCGCG 
CGCAGGGCGG CCGAGCTGGG TGCCAGGGCC GCCGTGGTGG AGAGCCACAA GCTGGGTGGC 
ACTTGCGTGA ATGTTGGATG TGTACCCAAA AAGGTAATGT GGAACACAGC TGTCCACTCT 
GAATTCATGC ATGATCATGC TGATTATGGC TTTCCAAGTT GTGAGGGTAA ATTCAATTGG 
CGTGTTATTA AGGAAAAGCG GGATGCCTAT GTGAGCCGCC TGAATGCCAT CTATCAAAAC 
AATCTCACCA AGTCCCATAT AGAAATCATC CGTGGCCATG CAGCCTTCAC GAGTGATCCC 
AAGCCCACAA TAGAGGTCAG TGGGAAAAAG TACACCGCCC CACACATCCT GATCGCCACA 
GGTGGTATGC CCTCCACCCC TCATGAGAGC CAGATCCCCG GTGCCAGCTT AGGAATAACC 
AGCGATGGAT TTTTTCAGCT GGAAGAATTG CCCGGCCGCA GCGTCATTGT TGGTGCAGGT 
TACATTGCTG TGGAGATGGC AGGGATCCTG TCAGCCCTGG GTTCTAAGAC ATCACTGATG 
ATACGGCATG ATAAGGTACT TAGAAGTTTT GATTCAATGA TCAGCACCAA CTGCACGGAG 
GAGCTGGAGA ACGCTGGCGT GGAGGTGCTG AAGTTCTCCC AGGGGATTCA AACCGATGAC 
AAGGGTCATA TCATCGTAGA CGAATTCCAG AATACCAACG TCAAAGGCAT CTATGCAGTT 
GGGGATGTAT GTGGAAAAGC TCTTCTTACT CCAGTTGCAA TAGCTGCTGG CCGAAAACTT 
GCCCATCGAC TTTTTGAATA TAAGGAAGAT TCCAAATTAG ATTATAACAA CATCCCAACT 
GTGGTCTTCA GCCACCCCCC TATTGGGACA GTGGGACTCA CGGAAGATGA AGCCATTCAT 
AAATATGGAA TAGAAAATGT GAAGACCTAT TCAACGAGCT TTACCCCGAT GTATCACGCA 
GTTACCAAAA GGAAAACAAA ATGTGTGATG AAAATGGTCT GTGCTAACAA GGAAGAAAAG 
GTGGTTGGGA TCCATATGCA GGGACTTGGG TGTGATGAAA TGCTGCAGGG TTTTGCTGTT 
GCAGTGAAGA TGGGAGCAAC GAAGGCAGAC TTTGACAACA CAGTCGCCAT TCACCCTACC 
TCTTCAGAAG AGCTGGTCAC ACTTCGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GSR ( NM_001195104.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182033.1 Homo sapiens glutathione-disulfide reductase (GSR), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu08622
Clone ID Related Accession (Same CDS sequence)	NM_001195104.2
Accession Version	NM_001195104.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1323bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-29
Organism	Homo sapiens(human)
Product	glutathione reductase, mitochondrial isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB988964.1, BM148117.1, AB519181.1, AC103959.18 and CA944703.1. On May 5, 2017 this sequence version replaced NM_001195104.1. Transcript Variant: This variant (4, also known as delta8+9) lacks two consecutive coding exons, as compared to variant 1. The reading frame is not affected and the resulting isoform (4) lacks an internal segment, as compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB519181.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 10708558; reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCCCTGC TGCCCCGAGC CCTGAGCGCC GGCGCGGGAC CGAGCTGGCG GCGGGCGGCG 
CGCGCCTTCC GAGGCTTCCT GCTGCTTCTG CCCGAGCCCG CGGCCCTCAC GCGCGCCCTC 
TCCCGTGCCA TGGCCTGCAG GCAGGAGCCG CAGCCGCAGG GCCCGCCGCC CGCTGCTGGC 
GCCGTGGCCT CCTATGACTA CCTGGTGATC GGGGGCGGCT CGGGCGGGCT GGCCAGCGCG 
CGCAGGGCGG CCGAGCTGGG TGCCAGGGCC GCCGTGGTGG AGAGCCACAA GCTGGGTGGC 
ACTTGCGTGA ATGTTGGATG TGTACCCAAA AAGGTAATGT GGAACACAGC TGTCCACTCT 
GAATTCATGC ATGATCATGC TGATTATGGC TTTCCAAGTT GTGAGGGTAA ATTCAATTGG 
CGTGTTATTA AGGAAAAGCG GGATGCCTAT GTGAGCCGCC TGAATGCCAT CTATCAAAAC 
AATCTCACCA AGTCCCATAT AGAAATCATC CGTGGCCATG CAGCCTTCAC GAGTGATCCC 
AAGCCCACAA TAGAGGTCAG TGGGAAAAAG TACACCGCCC CACACATCCT GATCGCCACA 
GGTGGTATGC CCTCCACCCC TCATGAGAGC CAGATCCCCG GTGCCAGCTT AGGAATAACC 
AGCGATGGAT TTTTTCAGCT GGAAGAATTG CCCGGCCGCA GCGTCATTGT TGGTGCAGGT 
TACATTGCTG TGGAGATGGC AGGGATCCTG TCAGCCCTGG GTTCTAAGAC ATCACTGATG 
ATACGGCATG ATAAGGGGAT TCAAACCGAT GACAAGGGTC ATATCATCGT AGACGAATTC 
CAGAATACCA ACGTCAAAGG CATCTATGCA GTTGGGGATG TATGTGGAAA AGCTCTTCTT 
ACTCCAGTTG CAATAGCTGC TGGCCGAAAA CTTGCCCATC GACTTTTTGA ATATAAGGAA 
GATTCCAAAT TAGATTATAA CAACATCCCA ACTGTGGTCT TCAGCCACCC CCCTATTGGG 
ACAGTGGGAC TCACGGAAGA TGAAGCCATT CATAAATATG GAATAGAAAA TGTGAAGACC 
TATTCAACGA GCTTTACCCC GATGTATCAC GCAGTTACCA AAAGGAAAAC AAAATGTGTG 
ATGAAAATGG TCTGTGCTAA CAAGGAAGAA AAGGTGGTTG GGATCCATAT GCAGGGACTT 
GGGTGTGATG AAATGCTGCA GGGTTTTGCT GTTGCAGTGA AGATGGGAGC AACGAAGGCA 
GACTTTGACA ACACAGTCGC CATTCACCCT ACCTCTTCAG AAGAGCTGGT CACACTTCGT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182033.1
CDS	165..1487
Translation	MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR

Target ORF information:

RefSeq Version	NM_001195104.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glutathione-disulfide reductase (GSR), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195104.2

ORF Insert Sequence:

ATGGCCCTGC TGCCCCGAGC CCTGAGCGCC GGCGCGGGAC CGAGCTGGCG GCGGGCGGCG 
CGCGCCTTCC GAGGCTTCCT GCTGCTTCTG CCCGAGCCCG CGGCCCTCAC GCGCGCCCTC 
TCCCGTGCCA TGGCCTGCAG GCAGGAGCCG CAGCCGCAGG GCCCGCCGCC CGCTGCTGGC 
GCCGTGGCCT CCTATGACTA CCTGGTGATC GGGGGCGGCT CGGGCGGGCT GGCCAGCGCG 
CGCAGGGCGG CCGAGCTGGG TGCCAGGGCC GCCGTGGTGG AGAGCCACAA GCTGGGTGGC 
ACTTGCGTGA ATGTTGGATG TGTACCCAAA AAGGTAATGT GGAACACAGC TGTCCACTCT 
GAATTCATGC ATGATCATGC TGATTATGGC TTTCCAAGTT GTGAGGGTAA ATTCAATTGG 
CGTGTTATTA AGGAAAAGCG GGATGCCTAT GTGAGCCGCC TGAATGCCAT CTATCAAAAC 
AATCTCACCA AGTCCCATAT AGAAATCATC CGTGGCCATG CAGCCTTCAC GAGTGATCCC 
AAGCCCACAA TAGAGGTCAG TGGGAAAAAG TACACCGCCC CACACATCCT GATCGCCACA 
GGTGGTATGC CCTCCACCCC TCATGAGAGC CAGATCCCCG GTGCCAGCTT AGGAATAACC 
AGCGATGGAT TTTTTCAGCT GGAAGAATTG CCCGGCCGCA GCGTCATTGT TGGTGCAGGT 
TACATTGCTG TGGAGATGGC AGGGATCCTG TCAGCCCTGG GTTCTAAGAC ATCACTGATG 
ATACGGCATG ATAAGGGGAT TCAAACCGAT GACAAGGGTC ATATCATCGT AGACGAATTC 
CAGAATACCA ACGTCAAAGG CATCTATGCA GTTGGGGATG TATGTGGAAA AGCTCTTCTT 
ACTCCAGTTG CAATAGCTGC TGGCCGAAAA CTTGCCCATC GACTTTTTGA ATATAAGGAA 
GATTCCAAAT TAGATTATAA CAACATCCCA ACTGTGGTCT TCAGCCACCC CCCTATTGGG 
ACAGTGGGAC TCACGGAAGA TGAAGCCATT CATAAATATG GAATAGAAAA TGTGAAGACC 
TATTCAACGA GCTTTACCCC GATGTATCAC GCAGTTACCA AAAGGAAAAC AAAATGTGTG 
ATGAAAATGG TCTGTGCTAA CAAGGAAGAA AAGGTGGTTG GGATCCATAT GCAGGGACTT 
GGGTGTGATG AAATGCTGCA GGGTTTTGCT GTTGCAGTGA AGATGGGAGC AACGAAGGCA 
GACTTTGACA ACACAGTCGC CATTCACCCT ACCTCTTCAG AAGAGCTGGT CACACTTCGT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis.
Journal of neurochemistry144(1)93-104(2018 Jan)
Zhu Z,Du S,Du Y,Ren J,Ying G,Yan Z

Effect of exercise intensity on Nrf2 signalling in young men.
Free radical research51(6)646-655(2017 Jun)
Done AJ,Newell MJ,Traustad?ttir T

Plasma glutathione reductase activity and?prognosis of septic shock.
The Journal of surgical research200(1)298-307(2016 Jan)
Kim JS,Kwon WY,Suh GJ,Kim KS,Jung YS,Kim SH,Lee SE

[MODERN METHODS OF PROGNOSTICATION OF THE RECURRENCES OCCURRENCE AFTER SURGICAL TREATMENT OF THE MAMMARY GLAND BENIGN TUMORS].
Klinichna khirurhiia(5)58-60(2015 May)
Usenko OY,Romak RP

Reduction of mitochondrial protein mitoNEET [2Fe-2S] clusters by human glutathione reductase.
Free radical biology & medicine81119-27(2015 Apr)
Landry AP,Cheng Z,Ding H

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GSR cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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