SLC25A6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC25A6
Entrez Gene ID	293
Full Name	solute carrier family 25 member 6
Synonyms	AAC3,ANT,ANT 2,ANT 3,ANT3,ANT3Y
General protein information	Preferred Names solute carrier family 25 member 6 Names ADP/ATP translocase 3 ADP,ATP carrier protein ADP,ATP carrier protein 3 ADP,ATP carrier protein, liver ADP/ATP translocator of liver adenine nucleotide translocator 3 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X\|Y Map Location: Xp22.33 and Yp11.2
Summary	This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013].
Disorder MIM:	300151

mRNA and Protein(s)

mRNA	Protein	Name
NM_001636.4	NP_001627.2	ADP/ATP translocase 3
NM_001636.3	NP_001627.2	ADP/ATP translocase 3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SLC25A6	XP_005642119.1
Danio rerio (zebrafish)	slc25a6	NP_001122204.1
Caenorhabditis elegans (roundworm)	ant-1.4	NP_501440.1
Caenorhabditis elegans (roundworm)	ant-1.3	NP_501727.1
Homo sapiens (human)	SLC25A6	NP_001627.2
	SLC25A6	XP_001114519.1
Drosophila melanogaster (fruit fly)	Ant2	NP_001259432.1
Anopheles gambiae (African malaria mosquito)	ADT1_ANOGA	XP_308964.2
Caenorhabditis elegans (roundworm)	ant-1.2	NP_491927.1
Bos taurus (cattle)	SLC25A6	NP_777085.1
Caenorhabditis elegans (roundworm)	ant-1.1	NP_001022799.1
Rattus norvegicus (Norway rat)	Slc25a6	XP_006254997.1
Gallus gallus (chicken)	SLC25A6	NP_989562.2

Gene Ontology
Bibliography

Related articles in PubMed

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-?B Signaling.
Malty RH, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, Minic Z, Goebels F, Musso G, Wu Z, Abou-Tok H, Meyer M, Deineko V, Kassir S, Sidhu V, Jessulat M, Scott NE, Xiong X, Vlasblom J, Prasad B, Foster LJ, Alberio T, Garavaglia B, Yu H, Bader GD, Nakamura K, Parkinson J, Babu M
Cell systems5(6)564-577.e12(2017 Dec)

Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.
Gavald?-Navarro A, Mampel T, Vi?as O
Open biology6(2)150108(2016 Feb)

Human cytomegalovirus miR-UL36-5p inhibits apoptosis via downregulation of adenine nucleotide translocator 3 in cultured cells.
Guo X, Huang Y, Qi Y, Liu Z, Ma Y, Shao Y, Jiang S, Sun Z, Ruan Q
Archives of virology160(10)2483-90(2015 Oct)

Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.
Martin I, Kim JW, Lee BD, Kang HC, Xu JC, Jia H, Stankowski J, Kim MS, Zhong J, Kumar M, Andrabi SA, Xiong Y, Dickson DW, Wszolek ZK, Pandey A, Dawson TM, Dawson VL
Cell157(2)472-485(2014 Apr)

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Zanivan S, Maione F, Hein MY, Hern?ndez-Fernaud JR, Ostasiewicz P, Giraudo E, Mann M
Molecular & cellular proteomics : MCP12(12)3599-611(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

cancer cells require both hANT2 and hANT3, depending on their proliferation status: hANT2 when proliferation rates are high, and hANT3 when proliferation slows.
Title: Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.

Human ANT3 expression is directly downregulated by overexpression of hcmv-miR-UL36-5p.
Title: Human cytomegalovirus miR-UL36-5p inhibits apoptosis via downregulation of adenine nucleotide translocator 3 in cultured cells.

Compares and contrasts all the known human SLC25A* genes and includes functional information.
Title: The mitochondrial transporter family SLC25: identification, properties and physiopathology.

The dynamics of the molecular interactions between the C-terminal region of PB1-F2 protein and VDAC1 and ANT3 were expounded by employing an in silico approach.
Title: Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: an in silico approach.

These data suggest that the down-regulation of ANT3 levels upon stimulation with CPT may be involved in the molecular mechanism underlying acquired resistance to camptothecin.
Title: Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells.

The following SLC25A6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC25A6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19558	NM_001636.4 Latest version!	Homo sapiens solute carrier family 25 member 6 (SLC25A6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu19558	NM_001636.3	Homo sapiens solute carrier family 25 member 6 (SLC25A6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC25A6 ( NM_001636.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001627.2 Homo sapiens solute carrier family 25 member 6 (SLC25A6), mRNA.

Price & Availability↑

CloneID	OHu19558
Clone ID Related Accession (Same CDS sequence)	NM_001636.4 , NM_001636.3
Accession Version	NM_001636.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	ADP/ATP translocase 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB150341.1, BC007850.2 and BC014775.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001636.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.26358.1, SRR3476690.261641.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000381401.11/ ENSP00000370808.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACGGAAC AGGCCATCTC CTTCGCCAAA GACTTCTTGG CCGGAGGCAT CGCCGCCGCC 
ATCTCCAAGA CGGCCGTGGC TCCGATCGAG CGGGTCAAGC TGCTGCTGCA GGTCCAGCAC 
GCCAGCAAGC AGATCGCCGC CGACAAGCAG TACAAGGGCA TCGTGGACTG CATTGTCCGC 
ATCCCCAAGG AGCAGGGCGT GCTGTCCTTC TGGAGGGGCA ACCTTGCCAA CGTCATTCGC 
TACTTCCCCA CTCAAGCCCT CAACTTCGCC TTCAAGGATA AGTACAAGCA GATCTTCCTG 
GGGGGCGTGG ACAAGCACAC GCAGTTCTGG AGGTACTTTG CGGGCAACCT GGCCTCCGGC 
GGTGCGGCCG GCGCGACCTC CCTCTGCTTC GTGTACCCGC TGGATTTCGC CAGAACCCGC 
CTGGCAGCGG ACGTGGGAAA GTCAGGCACA GAGCGCGAGT TCCGAGGCCT GGGAGACTGC 
CTGGTGAAGA TCACCAAGTC CGACGGCATC CGGGGCCTGT ACCAGGGCTT CAGTGTCTCC 
GTGCAGGGCA TCATCATCTA CCGGGCGGCC TACTTCGGCG TGTACGATAC GGCCAAGGGC 
ATGCTCCCCG ACCCCAAGAA CACGCACATC GTGGTGAGCT GGATGATCGC GCAGACCGTG 
ACGGCCGTGG CCGGCGTGGT GTCCTACCCC TTCGACACGG TGCGGCGGCG CATGATGATG 
CAGTCCGGGC GCAAAGGAGC TGACATCATG TACACGGGCA CCGTCGACTG TTGGAGGAAG 
ATCTTCAGAG ATGAGGGGGG CAAGGCCTTC TTCAAGGGTG CGTGGTCCAA CGTCCTGCGG 
GGCATGGGGG GCGCCTTCGT GCTGGTCCTG TACGACGAGC TCAAGAAGGT GATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001627.2
CDS	105..1001
Translation	MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI

Target ORF information:

RefSeq Version	NM_001636.4
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 25 member 6 (SLC25A6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001636.4

ORF Insert Sequence:

ATGACGGAAC AGGCCATCTC CTTCGCCAAA GACTTCTTGG CCGGAGGCAT CGCCGCCGCC 
ATCTCCAAGA CGGCCGTGGC TCCGATCGAG CGGGTCAAGC TGCTGCTGCA GGTCCAGCAC 
GCCAGCAAGC AGATCGCCGC CGACAAGCAG TACAAGGGCA TCGTGGACTG CATTGTCCGC 
ATCCCCAAGG AGCAGGGCGT GCTGTCCTTC TGGAGGGGCA ACCTTGCCAA CGTCATTCGC 
TACTTCCCCA CTCAAGCCCT CAACTTCGCC TTCAAGGATA AGTACAAGCA GATCTTCCTG 
GGGGGCGTGG ACAAGCACAC GCAGTTCTGG AGGTACTTTG CGGGCAACCT GGCCTCCGGC 
GGTGCGGCCG GCGCGACCTC CCTCTGCTTC GTGTACCCGC TGGATTTCGC CAGAACCCGC 
CTGGCAGCGG ACGTGGGAAA GTCAGGCACA GAGCGCGAGT TCCGAGGCCT GGGAGACTGC 
CTGGTGAAGA TCACCAAGTC CGACGGCATC CGGGGCCTGT ACCAGGGCTT CAGTGTCTCC 
GTGCAGGGCA TCATCATCTA CCGGGCGGCC TACTTCGGCG TGTACGATAC GGCCAAGGGC 
ATGCTCCCCG ACCCCAAGAA CACGCACATC GTGGTGAGCT GGATGATCGC GCAGACCGTG 
ACGGCCGTGG CCGGCGTGGT GTCCTACCCC TTCGACACGG TGCGGCGGCG CATGATGATG 
CAGTCCGGGC GCAAAGGAGC TGACATCATG TACACGGGCA CCGTCGACTG TTGGAGGAAG 
ATCTTCAGAG ATGAGGGGGG CAAGGCCTTC TTCAAGGGTG CGTGGTCCAA CGTCCTGCGG 
GGCATGGGGG GCGCCTTCGT GCTGGTCCTG TACGACGAGC TCAAGAAGGT GATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC25A6 ( NM_001636.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001627.2 Homo sapiens solute carrier family 25 member 6 (SLC25A6), mRNA.

Price & Availability↑

CloneID	OHu19558
Clone ID Related Accession (Same CDS sequence)	NM_001636.4 , NM_001636.3
Accession Version	NM_001636.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	ADP/ATP translocase 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB150341.1, BC007850.2 and BC014775.1. This sequence is a reference standard in the RefSeqGene project. On Sep 15, 2009 this sequence version replaced NM_001636.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.484261.1, SRR1163655.662534.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACGGAAC AGGCCATCTC CTTCGCCAAA GACTTCTTGG CCGGAGGCAT CGCCGCCGCC 
ATCTCCAAGA CGGCCGTGGC TCCGATCGAG CGGGTCAAGC TGCTGCTGCA GGTCCAGCAC 
GCCAGCAAGC AGATCGCCGC CGACAAGCAG TACAAGGGCA TCGTGGACTG CATTGTCCGC 
ATCCCCAAGG AGCAGGGCGT GCTGTCCTTC TGGAGGGGCA ACCTTGCCAA CGTCATTCGC 
TACTTCCCCA CTCAAGCCCT CAACTTCGCC TTCAAGGATA AGTACAAGCA GATCTTCCTG 
GGGGGCGTGG ACAAGCACAC GCAGTTCTGG AGGTACTTTG CGGGCAACCT GGCCTCCGGC 
GGTGCGGCCG GCGCGACCTC CCTCTGCTTC GTGTACCCGC TGGATTTCGC CAGAACCCGC 
CTGGCAGCGG ACGTGGGAAA GTCAGGCACA GAGCGCGAGT TCCGAGGCCT GGGAGACTGC 
CTGGTGAAGA TCACCAAGTC CGACGGCATC CGGGGCCTGT ACCAGGGCTT CAGTGTCTCC 
GTGCAGGGCA TCATCATCTA CCGGGCGGCC TACTTCGGCG TGTACGATAC GGCCAAGGGC 
ATGCTCCCCG ACCCCAAGAA CACGCACATC GTGGTGAGCT GGATGATCGC GCAGACCGTG 
ACGGCCGTGG CCGGCGTGGT GTCCTACCCC TTCGACACGG TGCGGCGGCG CATGATGATG 
CAGTCCGGGC GCAAAGGAGC TGACATCATG TACACGGGCA CCGTCGACTG TTGGAGGAAG 
ATCTTCAGAG ATGAGGGGGG CAAGGCCTTC TTCAAGGGTG CGTGGTCCAA CGTCCTGCGG 
GGCATGGGGG GCGCCTTCGT GCTGGTCCTG TACGACGAGC TCAAGAAGGT GATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001627.2
CDS	138..1034
Translation	MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI

Target ORF information:

RefSeq Version	NM_001636.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 25 member 6 (SLC25A6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001636.3

ORF Insert Sequence:

ATGACGGAAC AGGCCATCTC CTTCGCCAAA GACTTCTTGG CCGGAGGCAT CGCCGCCGCC 
ATCTCCAAGA CGGCCGTGGC TCCGATCGAG CGGGTCAAGC TGCTGCTGCA GGTCCAGCAC 
GCCAGCAAGC AGATCGCCGC CGACAAGCAG TACAAGGGCA TCGTGGACTG CATTGTCCGC 
ATCCCCAAGG AGCAGGGCGT GCTGTCCTTC TGGAGGGGCA ACCTTGCCAA CGTCATTCGC 
TACTTCCCCA CTCAAGCCCT CAACTTCGCC TTCAAGGATA AGTACAAGCA GATCTTCCTG 
GGGGGCGTGG ACAAGCACAC GCAGTTCTGG AGGTACTTTG CGGGCAACCT GGCCTCCGGC 
GGTGCGGCCG GCGCGACCTC CCTCTGCTTC GTGTACCCGC TGGATTTCGC CAGAACCCGC 
CTGGCAGCGG ACGTGGGAAA GTCAGGCACA GAGCGCGAGT TCCGAGGCCT GGGAGACTGC 
CTGGTGAAGA TCACCAAGTC CGACGGCATC CGGGGCCTGT ACCAGGGCTT CAGTGTCTCC 
GTGCAGGGCA TCATCATCTA CCGGGCGGCC TACTTCGGCG TGTACGATAC GGCCAAGGGC 
ATGCTCCCCG ACCCCAAGAA CACGCACATC GTGGTGAGCT GGATGATCGC GCAGACCGTG 
ACGGCCGTGG CCGGCGTGGT GTCCTACCCC TTCGACACGG TGCGGCGGCG CATGATGATG 
CAGTCCGGGC GCAAAGGAGC TGACATCATG TACACGGGCA CCGTCGACTG TTGGAGGAAG 
ATCTTCAGAG ATGAGGGGGG CAAGGCCTTC TTCAAGGGTG CGTGGTCCAA CGTCCTGCGG 
GGCATGGGGG GCGCCTTCGT GCTGGTCCTG TACGACGAGC TCAAGAAGGT GATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-?B Signaling.
Cell systems5(6)564-577.e12(2017 Dec)
Malty RH,Aoki H,Kumar A,Phanse S,Amin S,Zhang Q,Minic Z,Goebels F,Musso G,Wu Z,Abou-Tok H,Meyer M,Deineko V,Kassir S,Sidhu V,Jessulat M,Scott NE,Xiong X,Vlasblom J,Prasad B,Foster LJ,Alberio T,Garavaglia B,Yu H,Bader GD,Nakamura K,Parkinson J,Babu M

Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.
Open biology6(2)150108(2016 Feb)
Gavald?-Navarro A,Mampel T,Vi?as O

Human cytomegalovirus miR-UL36-5p inhibits apoptosis via downregulation of adenine nucleotide translocator 3 in cultured cells.
Archives of virology160(10)2483-90(2015 Oct)
Guo X,Huang Y,Qi Y,Liu Z,Ma Y,Shao Y,Jiang S,Sun Z,Ruan Q

Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.
Cell157(2)472-485(2014 Apr)
Martin I,Kim JW,Lee BD,Kang HC,Xu JC,Jia H,Stankowski J,Kim MS,Zhong J,Kumar M,Andrabi SA,Xiong Y,Dickson DW,Wszolek ZK,Pandey A,Dawson TM,Dawson VL

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Molecular & cellular proteomics : MCP12(12)3599-611(2013 Dec)
Zanivan S,Maione F,Hein MY,Hern?ndez-Fernaud JR,Ostasiewicz P,Giraudo E,Mann M

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SLC25A6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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