SLC25A5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC25A5
Entrez Gene ID	292
Full Name	solute carrier family 25 member 5
Synonyms	2F1,AAC2,ANT2,T2,T3
General protein information	Preferred Names solute carrier family 25 member 5 Names ADP/ATP translocase 2 ADP,ATP carrier protein, fibroblast isoform adenine nucleotide translocator 2 (fibroblast) solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq24
Summary	This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013].
Disorder MIM:	300150

mRNA and Protein(s)

mRNA	Protein	Name
NM_001152.4	NP_001143.2	ADP/ATP translocase 2
NM_001152.5	NP_001143.2	ADP/ATP translocase 2

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	MGC75700	NP_988913.1
Bos taurus (cattle)	SLC25A5	NP_777084.1
Homo sapiens (human)	SLC25A5	NP_001143.2
Canis lupus familiaris (dog)	SLC25A5	XP_851701.1
	SLC25A5	XP_002806416.1
Mus musculus (house mouse)	Slc25a5	NP_031477.1
Rattus norvegicus (Norway rat)	Slc25a5	NP_476443.1
Gallus gallus (chicken)	SLC25A5	XP_004940900.1
Danio rerio (zebrafish)	slc25a5	NP_775354.1

Gene Ontology
Bibliography

Related articles in PubMed

Upregulation of miR-137 reverses sorafenib resistance and cancer-initiating cell phenotypes by degrading ANT2 in hepatocellular carcinoma.
Lu AQ, Lv B, Qiu F, Wang XY, Cao XH
Oncology reports37(4)2071-2078(2017 Apr)

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Floyd BJ, Wilkerson EM, Veling MT, Minogue CE, Xia C, Beebe ET, Wrobel RL, Cho H, Kremer LS, Alston CL, Gromek KA, Dolan BK, Ulbrich A, Stefely JA, Bohl SL, Werner KM, Jochem A, Westphall MS, Rensvold JW, Taylor RW, Prokisch H, Kim JP, Coon JJ, Pagliarini DJ
Molecular cell63(4)621-632(2016 Aug)

Targeting Adenine Nucleotide Translocase-2 (ANT2) to Overcome Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Non-Small Cell Lung Cancer.
Jang JY, Kim YG, Nam SJ, Keam B, Kim TM, Jeon YK, Kim CW
Molecular cancer therapeutics15(6)1387-96(2016 06)

ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells.
Baik SH, Lee J, Lee YS, Jang JY, Kim CW
Experimental & molecular medicine48e222(2016 Mar)

Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.
Gavald?-Navarro A, Mampel T, Vi?as O
Open biology6(2)150108(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study found that ANT2 was upregulated in sorafenibresistant hepatocellular carcinoma Huh7 cell line and its overexpression promoted sorafenib resistance.
Title: Upregulation of miR-137 reverses sorafenib resistance and cancer-initiating cell phenotypes by degrading ANT2 in hepatocellular carcinoma.

Findings suggest that ANT2 overexpression contributes to EGFR-TKI resistance in non-small cell lung cancer.
Title: Targeting Adenine Nucleotide Translocase-2 (ANT2) to Overcome Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Non-Small Cell Lung Cancer.

IFNgamma induces oxidative stress, DNA damage and tumor cell senescence via TGFbeta/SMAD signaling-dependent induction of Nox4 and suppression of ANT2
Title: IFN? induces oxidative stress, DNA damage and tumor cell senescence via TGF?/SMAD signaling-dependent induction of Nox4 and suppression of ANT2.

ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells.
Title: ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells.

cancer cells require both hANT2 and hANT3, depending on their proliferation status: hANT2 when proliferation rates are high, and hANT3 when proliferation slows.
Title: Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.

The following SLC25A5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC25A5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18316	NM_001152.5 Latest version!	Homo sapiens solute carrier family 25 member 5 (SLC25A5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu18316	NM_001152.4	Homo sapiens solute carrier family 25 member 5 (SLC25A5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC25A5 ( NM_001152.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001143.2 Homo sapiens solute carrier family 25 member 5 (SLC25A5), mRNA.

Price & Availability↑

CloneID	OHu18316
Clone ID Related Accession (Same CDS sequence)	NM_001152.4 , NM_001152.5
Accession Version	NM_001152.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	ADP/ATP translocase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DR759917.1, BC068199.1, BC056160.1 and BQ223988.1. This sequence is a reference standard in the RefSeqGene project. On Sep 15, 2009 this sequence version replaced NM_001152.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.225985.1, SRR1163655.230849.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACAGATG CCGCTGTGTC CTTCGCCAAG GACTTCCTGG CAGGTGGAGT GGCCGCAGCC 
ATCTCCAAGA CGGCGGTAGC GCCCATCGAG CGGGTCAAGC TGCTGCTGCA GGTGCAGCAT 
GCCAGCAAGC AGATCACTGC AGATAAGCAA TACAAAGGCA TTATAGACTG CGTGGTCCGT 
ATTCCCAAGG AGCAGGGAGT TCTGTCCTTC TGGCGCGGTA ACCTGGCCAA TGTCATCAGA 
TACTTCCCCA CCCAGGCTCT TAACTTCGCC TTCAAAGATA AATACAAGCA GATCTTCCTG 
GGTGGTGTGG ACAAGAGAAC CCAGTTTTGG CTCTACTTTG CAGGGAATCT GGCATCGGGT 
GGTGCCGCAG GGGCCACATC CCTGTGTTTT GTGTACCCTC TTGATTTTGC CCGTACCCGT 
CTAGCAGCTG ATGTGGGTAA AGCTGGAGCT GAAAGGGAAT TCCGAGGCCT CGGTGACTGC 
CTGGTTAAGA TCTACAAATC TGATGGGATT AAGGGCCTGT ACCAAGGCTT TAACGTGTCT 
GTGCAGGGTA TTATCATCTA CCGAGCCGCC TACTTCGGTA TCTATGACAC TGCAAAGGGA 
ATGCTTCCGG ATCCCAAGAA CACTCACATC GTCATCAGCT GGATGATCGC ACAGACTGTC 
ACTGCTGTTG CCGGGTTGAC TTCCTATCCA TTTGACACTG TTCGCCGCCG CATGATGATG 
CAGTCAGGGC GCAAAGGAAC TGACATCATG TACACAGGCA CGCTTGACTG CTGGCGGAAG 
ATTGCTCGTG ATGAAGGAGG CAAAGCTTTT TTCAAGGGTG CATGGTCCAA TGTTCTCAGA 
GGCATGGGTG GTGCTTTTGT GCTTGTCTTG TATGATGAAA TCAAGAAGTA CACATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001143.2
CDS	117..1013
Translation	MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT

Target ORF information:

RefSeq Version	NM_001152.4
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 25 member 5 (SLC25A5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001152.4

ORF Insert Sequence:

ATGACAGATG CCGCTGTGTC CTTCGCCAAG GACTTCCTGG CAGGTGGAGT GGCCGCAGCC 
ATCTCCAAGA CGGCGGTAGC GCCCATCGAG CGGGTCAAGC TGCTGCTGCA GGTGCAGCAT 
GCCAGCAAGC AGATCACTGC AGATAAGCAA TACAAAGGCA TTATAGACTG CGTGGTCCGT 
ATTCCCAAGG AGCAGGGAGT TCTGTCCTTC TGGCGCGGTA ACCTGGCCAA TGTCATCAGA 
TACTTCCCCA CCCAGGCTCT TAACTTCGCC TTCAAAGATA AATACAAGCA GATCTTCCTG 
GGTGGTGTGG ACAAGAGAAC CCAGTTTTGG CTCTACTTTG CAGGGAATCT GGCATCGGGT 
GGTGCCGCAG GGGCCACATC CCTGTGTTTT GTGTACCCTC TTGATTTTGC CCGTACCCGT 
CTAGCAGCTG ATGTGGGTAA AGCTGGAGCT GAAAGGGAAT TCCGAGGCCT CGGTGACTGC 
CTGGTTAAGA TCTACAAATC TGATGGGATT AAGGGCCTGT ACCAAGGCTT TAACGTGTCT 
GTGCAGGGTA TTATCATCTA CCGAGCCGCC TACTTCGGTA TCTATGACAC TGCAAAGGGA 
ATGCTTCCGG ATCCCAAGAA CACTCACATC GTCATCAGCT GGATGATCGC ACAGACTGTC 
ACTGCTGTTG CCGGGTTGAC TTCCTATCCA TTTGACACTG TTCGCCGCCG CATGATGATG 
CAGTCAGGGC GCAAAGGAAC TGACATCATG TACACAGGCA CGCTTGACTG CTGGCGGAAG 
ATTGCTCGTG ATGAAGGAGG CAAAGCTTTT TTCAAGGGTG CATGGTCCAA TGTTCTCAGA 
GGCATGGGTG GTGCTTTTGT GCTTGTCTTG TATGATGAAA TCAAGAAGTA CACATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC25A5 ( NM_001152.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001143.2 Homo sapiens solute carrier family 25 member 5 (SLC25A5), mRNA.

Price & Availability↑

CloneID	OHu18316
Clone ID Related Accession (Same CDS sequence)	NM_001152.4 , NM_001152.5
Accession Version	NM_001152.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	ADP/ATP translocase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DR759917.1, BC068199.1, BC056160.1 and BQ223988.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001152.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX325584.2, SRR5189667.224480.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000317881.9/ ENSP00000360671.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACAGATG CCGCTGTGTC CTTCGCCAAG GACTTCCTGG CAGGTGGAGT GGCCGCAGCC 
ATCTCCAAGA CGGCGGTAGC GCCCATCGAG CGGGTCAAGC TGCTGCTGCA GGTGCAGCAT 
GCCAGCAAGC AGATCACTGC AGATAAGCAA TACAAAGGCA TTATAGACTG CGTGGTCCGT 
ATTCCCAAGG AGCAGGGAGT TCTGTCCTTC TGGCGCGGTA ACCTGGCCAA TGTCATCAGA 
TACTTCCCCA CCCAGGCTCT TAACTTCGCC TTCAAAGATA AATACAAGCA GATCTTCCTG 
GGTGGTGTGG ACAAGAGAAC CCAGTTTTGG CTCTACTTTG CAGGGAATCT GGCATCGGGT 
GGTGCCGCAG GGGCCACATC CCTGTGTTTT GTGTACCCTC TTGATTTTGC CCGTACCCGT 
CTAGCAGCTG ATGTGGGTAA AGCTGGAGCT GAAAGGGAAT TCCGAGGCCT CGGTGACTGC 
CTGGTTAAGA TCTACAAATC TGATGGGATT AAGGGCCTGT ACCAAGGCTT TAACGTGTCT 
GTGCAGGGTA TTATCATCTA CCGAGCCGCC TACTTCGGTA TCTATGACAC TGCAAAGGGA 
ATGCTTCCGG ATCCCAAGAA CACTCACATC GTCATCAGCT GGATGATCGC ACAGACTGTC 
ACTGCTGTTG CCGGGTTGAC TTCCTATCCA TTTGACACTG TTCGCCGCCG CATGATGATG 
CAGTCAGGGC GCAAAGGAAC TGACATCATG TACACAGGCA CGCTTGACTG CTGGCGGAAG 
ATTGCTCGTG ATGAAGGAGG CAAAGCTTTT TTCAAGGGTG CATGGTCCAA TGTTCTCAGA 
GGCATGGGTG GTGCTTTTGT GCTTGTCTTG TATGATGAAA TCAAGAAGTA CACATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001143.2
CDS	73..969
Translation	MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT

Target ORF information:

RefSeq Version	NM_001152.5
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 25 member 5 (SLC25A5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001152.5

ORF Insert Sequence:

ATGACAGATG CCGCTGTGTC CTTCGCCAAG GACTTCCTGG CAGGTGGAGT GGCCGCAGCC 
ATCTCCAAGA CGGCGGTAGC GCCCATCGAG CGGGTCAAGC TGCTGCTGCA GGTGCAGCAT 
GCCAGCAAGC AGATCACTGC AGATAAGCAA TACAAAGGCA TTATAGACTG CGTGGTCCGT 
ATTCCCAAGG AGCAGGGAGT TCTGTCCTTC TGGCGCGGTA ACCTGGCCAA TGTCATCAGA 
TACTTCCCCA CCCAGGCTCT TAACTTCGCC TTCAAAGATA AATACAAGCA GATCTTCCTG 
GGTGGTGTGG ACAAGAGAAC CCAGTTTTGG CTCTACTTTG CAGGGAATCT GGCATCGGGT 
GGTGCCGCAG GGGCCACATC CCTGTGTTTT GTGTACCCTC TTGATTTTGC CCGTACCCGT 
CTAGCAGCTG ATGTGGGTAA AGCTGGAGCT GAAAGGGAAT TCCGAGGCCT CGGTGACTGC 
CTGGTTAAGA TCTACAAATC TGATGGGATT AAGGGCCTGT ACCAAGGCTT TAACGTGTCT 
GTGCAGGGTA TTATCATCTA CCGAGCCGCC TACTTCGGTA TCTATGACAC TGCAAAGGGA 
ATGCTTCCGG ATCCCAAGAA CACTCACATC GTCATCAGCT GGATGATCGC ACAGACTGTC 
ACTGCTGTTG CCGGGTTGAC TTCCTATCCA TTTGACACTG TTCGCCGCCG CATGATGATG 
CAGTCAGGGC GCAAAGGAAC TGACATCATG TACACAGGCA CGCTTGACTG CTGGCGGAAG 
ATTGCTCGTG ATGAAGGAGG CAAAGCTTTT TTCAAGGGTG CATGGTCCAA TGTTCTCAGA 
GGCATGGGTG GTGCTTTTGT GCTTGTCTTG TATGATGAAA TCAAGAAGTA CACATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Upregulation of miR-137 reverses sorafenib resistance and cancer-initiating cell phenotypes by degrading ANT2 in hepatocellular carcinoma.
Oncology reports37(4)2071-2078(2017 Apr)
Lu AQ,Lv B,Qiu F,Wang XY,Cao XH

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Molecular cell63(4)621-632(2016 Aug)
Floyd BJ,Wilkerson EM,Veling MT,Minogue CE,Xia C,Beebe ET,Wrobel RL,Cho H,Kremer LS,Alston CL,Gromek KA,Dolan BK,Ulbrich A,Stefely JA,Bohl SL,Werner KM,Jochem A,Westphall MS,Rensvold JW,Taylor RW,Prokisch H,Kim JP,Coon JJ,Pagliarini DJ

Targeting Adenine Nucleotide Translocase-2 (ANT2) to Overcome Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Non-Small Cell Lung Cancer.
Molecular cancer therapeutics15(6)1387-96(2016 06)
Jang JY,Kim YG,Nam SJ,Keam B,Kim TM,Jeon YK,Kim CW

ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells.
Experimental & molecular medicine48e222(2016 Mar)
Baik SH,Lee J,Lee YS,Jang JY,Kim CW

Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.
Open biology6(2)150108(2016 Feb)
Gavald?-Navarro A,Mampel T,Vi?as O

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SLC25A5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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