GRM3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GRM3
Entrez Gene ID	2913
Full Name	glutamate metabotropic receptor 3
Synonyms	GLUR3,GPRC1C,MGLUR3,mGlu3
General protein information	Preferred Names glutamate metabotropic receptor 3 Names metabotropic glutamate receptor 3 glutamate receptor, metabotropic 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q21.11-q21.12
Summary	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008].
Disorder MIM:	601115

mRNA and Protein(s)

mRNA	Protein	Name
XM_017012073.2	XP_016867562.1	metabotropic glutamate receptor 3 isoform X2
XM_017012073.1	XP_016867562.1	metabotropic glutamate receptor 3 isoform X2
XM_011516088.1	XP_011514390.1	metabotropic glutamate receptor 3 isoform X1
NM_000840.2	NP_000831.2	metabotropic glutamate receptor 3 isoform 1 precursor
NM_001363522.1	NP_001350451.1	metabotropic glutamate receptor 3 isoform 2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GRM3	NP_000831.2
Bos taurus (cattle)	GRM3	NP_001091592.1
Rattus norvegicus (Norway rat)	Grm3	NP_001099182.1
Pan troglodytes (chimpanzee)	GRM3	XP_001161278.1
	GRM3	XP_001107588.1
Mus musculus (house mouse)	Grm3	NP_862898.1
Danio rerio (zebrafish)	grm3	NP_001121815.1
Drosophila melanogaster (fruit fly)	mGluRA	NP_001259076.1
Xenopus tropicalis (tropical clawed frog)	grm3	XP_002935292.2
Canis lupus familiaris (dog)	GRM3	XP_005628844.1
Gallus gallus (chicken)	GRM3	XP_416842.3
Caenorhabditis elegans (roundworm)	mgl-1	NP_001123193.1

Gene Ontology
Bibliography

Related articles in PubMed

Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling.
Neto A, Ceol CJ
Pigment cell & melanoma research31(1)115-119(2018 Jan)

A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding.
Garc?a-Bea A, Bermudez I, Harrison PJ, Lane TA
Journal of psychopharmacology (Oxford, England)31(12)1519-1526(2017 Dec)

Meta-analysis supports GWAS-implicated link between GRM3 and schizophrenia risk.
Saini SM, Mancuso SG, Mostaid MS, Liu C, Pantelis C, Everall IP, Bousman CA
Translational psychiatry7(8)e1196(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results demonstrate that GRM3 expression is significantly upregulated in human colonic adenocarcinomas and colon cancer cell lines. This upregulation is mediated at the post-transcriptional level where miR-487b directly targets GRM3 to suppress its translation. Also, the fact that TGFbeta increases GRM3 protein stability provide novel mechanisms of post-transcriptional regulation of GRM3 in colon cancer.
Title: The miR-487b-3p/GRM3/TGF? signaling axis is an important regulator of colon cancer tumorigenesis.

Low GRM3 expression is associated with multiple myeloma and B-cell leukemia.
Title: Metabotropic glutamate receptor 3 is involved in B-cell-related tumor apoptosis.

Significant association was found between rs12704290 in GRM3 gene and schizophrenia(SCZ). A three-SNP LD spanning GRM3Delta4 splice site was significantly associated with SCZ. Interaction between the LD block and cognitive function was found in SCZ patients.
Title: Evaluation of relationship between GRM3 polymorphisms and cognitive function in schizophrenia of Han Chinese.

Results show that GRM3 rs274622 C carriers with schizophrenia were associated with significantly smaller prefrontal activation than patients with TT genotype
Title: Effect of metabotropic glutamate receptor-3 variants on prefrontal brain activity in schizophrenia: An imaging genetics study using multi-channel near-infrared spectroscopy.

Grm3 expression was decreased in B cells from patients with autoimmune diseases such as activated systemic lupus erythematosus and multiple sclerosis.
Title: Ligation of metabotropic glutamate receptor 3 (Grm3) ameliorates lupus-like disease by reducing B cells.

The following GRM3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GRM3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13051	NM_000840.2 Latest version!	Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
OHu58121	NM_001363522.1 Latest version!	Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu58121	XM_011516088.1 Latest version!	Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu97191	XM_017012073.2 Latest version!	Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu97191	XM_017012073.1	Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GRM3 ( NM_000840.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000831.2 Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13051
Clone ID Related Accession (Same CDS sequence)	NM_000840.2
Accession Version	NM_000840.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2640bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	metabotropic glutamate receptor 3 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC041407.1 and X77748.1. On or before Aug 31, 2013 this sequence version replaced XM_005250286.1, NM_000840.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041407.1, SRR1803613.6951.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGAAGATGT TGACAAGACT GCAAGTTCTT ACCTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GGGACCATAA CTTTCTAAGG AGAGAGATTA AAATAGAAGG TGACCTTGTT 
TTAGGGGGCC TGTTTCCTAT TAACGAAAAA GGCACTGGAA CTGAAGAATG TGGGCGAATC 
AATGAAGACC GAGGGATTCA ACGCCTGGAA GCCATGTTGT TTGCTATTGA TGAAATCAAC 
AAAGATGATT ACTTGCTACC AGGAGTGAAG TTGGGTGTTC ACATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTGGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACAAAAGTG 
GATGAAGCTG AGTATATGTG TCCTGATGGA TCCTATGCCA TTCAAGAAAA CATCCCACTT 
CTCATTGCAG GGGTCATTGG TGGCTCTTAT AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGCGGCTCT TCCAGATCCC TCAGATCAGC TACGCATCCA CCAGCGCCAA ACTCAGTGAT 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCCG ACTTCTACCA GGCCAAAGCC 
ATGGCTGAGA TCTTGCGCTT CTTCAACTGG ACCTACGTGT CCACAGTAGC CTCCGAGGGT 
GATTACGGGG AGACAGGGAT CGAGGCCTTC GAGCAGGAAG CCCGCCTGCG CAACATCTGC 
ATCGCTACGG CGGAGAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATC 
CGAGAACTGT TGCAGAAGCC CAACGCGCGC GTCGTGGTCC TCTTCATGCG CAGCGACGAC 
TCGCGGGAGC TCATTGCAGC CGCCAGCCGC GCCAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GCGCGCAGGA GAGCATCATC AAGGGCAGCG AGCATGTGGC CTACGGCGCC 
ATCACCCTGG AGCTGGCCTC CCAGCCTGTC CGCCAGTTCG ACCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAACCACCG CAACCCCTGG TTCCGGGACT TCTGGGAGCA AAAGTTTCAG 
TGCAGCCTCC AGAACAAACG CAACCACAGG CGCGTCTGCG ACAAGCACCT GGCCATCGAC 
AGCAGCAACT ACGAGCAAGA GTCCAAGATC ATGTTTGTGG TGAACGCGGT GTATGCCATG 
GCCCACGCTT TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACTACCAA GCTTTGTGAT 
GCTATGAAGA TCCTGGATGG GAAGAAGTTG TACAAGGATT ACTTGCTGAA AATCAACTTC 
ACGGCTCCAT TCAACCCAAA TAAAGATGCA GATAGCATAG TCAAGTTTGA CACTTTTGGA 
GATGGAATGG GGCGATACAA CGTGTTCAAT TTCCAAAATG TAGGTGGAAA GTATTCCTAC 
TTGAAAGTTG GTCACTGGGC AGAAACCTTA TCGCTAGATG TCAACTCTAT CCACTGGTCC 
CGGAACTCAG TCCCCACTTC CCAGTGCAGC GACCCCTGTG CCCCCAATGA AATGAAGAAT 
ATGCAACCAG GGGATGTCTG CTGCTGGATT TGCATCCCCT GTGAACCCTA CGAATACCTG 
GCTGATGAGT TTACCTGTAT GGATTGTGGG TCTGGACAGT GGCCCACTGC AGACCTAACT 
GGATGCTATG ACCTTCCTGA GGACTACATC AGGTGGGAAG ACGCCTGGGC CATTGGCCCA 
GTCACCATTG CCTGTCTGGG TTTTATGTGT ACATGCATGG TTGTAACTGT TTTTATCAAG 
CACAACAACA CACCCTTGGT CAAAGCATCG GGCCGAGAAC TCTGCTACAT CTTATTGTTT 
GGGGTTGGCC TGTCATACTG CATGACATTC TTCTTCATTG CCAAGCCATC ACCAGTCATC 
TGTGCATTGC GCCGACTCGG GCTGGGGAGT TCCTTCGCTA TCTGTTACTC AGCCCTGCTG 
ACCAAGACAA ACTGCATTGC CCGCATCTTC GATGGGGTCA AGAATGGCGC TCAGAGGCCA 
AAATTCATCA GCCCCAGTTC TCAGGTTTTC ATCTGCCTGG GTCTGATCCT GGTGCAAATT 
GTGATGGTGT CTGTGTGGCT CATCCTGGAG GCCCCAGGCA CCAGGAGGTA TACCCTTGCA 
GAGAAGCGGG AAACAGTCAT CCTAAAATGC AATGTCAAAG ATTCCAGCAT GTTGATCTCT 
CTTACCTACG ATGTGATCCT GGTGATCTTA TGCACTGTGT ACGCCTTCAA AACGCGGAAG 
TGCCCAGAAA ATTTCAACGA AGCTAAGTTC ATAGGTTTTA CCATGTACAC CACGTGCATC 
ATCTGGTTGG CCTTCCTCCC TATATTTTAT GTGACATCAA GTGACTACAG AGTGCAGACG 
ACAACCATGT GCATCTCTGT CAGCCTGAGT GGCTTTGTGG TCTTGGGCTG TTTGTTTGCA 
CCCAAGGTTC ACATCATCCT GTTTCAACCC CAGAAGAATG TTGTCACACA CAGACTGCAC 
CTCAACAGGT TCAGTGTCAG TGGAACTGGG ACCACATACT CTCAGTCCTC TGCAAGCACG 
TATGTGCCAA CGGTGTGCAA TGGGCGGGAA GTCCTCGACT CCACCACCTC ATCTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000831.2
CDS	1100..3739
Translation	MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL

Target ORF information:

RefSeq Version	NM_000840.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000840.2

ORF Insert Sequence:

ATGAAGATGT TGACAAGACT GCAAGTTCTT ACCTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GGGACCATAA CTTTCTAAGG AGAGAGATTA AAATAGAAGG TGACCTTGTT 
TTAGGGGGCC TGTTTCCTAT TAACGAAAAA GGCACTGGAA CTGAAGAATG TGGGCGAATC 
AATGAAGACC GAGGGATTCA ACGCCTGGAA GCCATGTTGT TTGCTATTGA TGAAATCAAC 
AAAGATGATT ACTTGCTACC AGGAGTGAAG TTGGGTGTTC ACATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTGGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACAAAAGTG 
GATGAAGCTG AGTATATGTG TCCTGATGGA TCCTATGCCA TTCAAGAAAA CATCCCACTT 
CTCATTGCAG GGGTCATTGG TGGCTCTTAT AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGCGGCTCT TCCAGATCCC TCAGATCAGC TACGCATCCA CCAGCGCCAA ACTCAGTGAT 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCCG ACTTCTACCA GGCCAAAGCC 
ATGGCTGAGA TCTTGCGCTT CTTCAACTGG ACCTACGTGT CCACAGTAGC CTCCGAGGGT 
GATTACGGGG AGACAGGGAT CGAGGCCTTC GAGCAGGAAG CCCGCCTGCG CAACATCTGC 
ATCGCTACGG CGGAGAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATC 
CGAGAACTGT TGCAGAAGCC CAACGCGCGC GTCGTGGTCC TCTTCATGCG CAGCGACGAC 
TCGCGGGAGC TCATTGCAGC CGCCAGCCGC GCCAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GCGCGCAGGA GAGCATCATC AAGGGCAGCG AGCATGTGGC CTACGGCGCC 
ATCACCCTGG AGCTGGCCTC CCAGCCTGTC CGCCAGTTCG ACCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAACCACCG CAACCCCTGG TTCCGGGACT TCTGGGAGCA AAAGTTTCAG 
TGCAGCCTCC AGAACAAACG CAACCACAGG CGCGTCTGCG ACAAGCACCT GGCCATCGAC 
AGCAGCAACT ACGAGCAAGA GTCCAAGATC ATGTTTGTGG TGAACGCGGT GTATGCCATG 
GCCCACGCTT TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACTACCAA GCTTTGTGAT 
GCTATGAAGA TCCTGGATGG GAAGAAGTTG TACAAGGATT ACTTGCTGAA AATCAACTTC 
ACGGCTCCAT TCAACCCAAA TAAAGATGCA GATAGCATAG TCAAGTTTGA CACTTTTGGA 
GATGGAATGG GGCGATACAA CGTGTTCAAT TTCCAAAATG TAGGTGGAAA GTATTCCTAC 
TTGAAAGTTG GTCACTGGGC AGAAACCTTA TCGCTAGATG TCAACTCTAT CCACTGGTCC 
CGGAACTCAG TCCCCACTTC CCAGTGCAGC GACCCCTGTG CCCCCAATGA AATGAAGAAT 
ATGCAACCAG GGGATGTCTG CTGCTGGATT TGCATCCCCT GTGAACCCTA CGAATACCTG 
GCTGATGAGT TTACCTGTAT GGATTGTGGG TCTGGACAGT GGCCCACTGC AGACCTAACT 
GGATGCTATG ACCTTCCTGA GGACTACATC AGGTGGGAAG ACGCCTGGGC CATTGGCCCA 
GTCACCATTG CCTGTCTGGG TTTTATGTGT ACATGCATGG TTGTAACTGT TTTTATCAAG 
CACAACAACA CACCCTTGGT CAAAGCATCG GGCCGAGAAC TCTGCTACAT CTTATTGTTT 
GGGGTTGGCC TGTCATACTG CATGACATTC TTCTTCATTG CCAAGCCATC ACCAGTCATC 
TGTGCATTGC GCCGACTCGG GCTGGGGAGT TCCTTCGCTA TCTGTTACTC AGCCCTGCTG 
ACCAAGACAA ACTGCATTGC CCGCATCTTC GATGGGGTCA AGAATGGCGC TCAGAGGCCA 
AAATTCATCA GCCCCAGTTC TCAGGTTTTC ATCTGCCTGG GTCTGATCCT GGTGCAAATT 
GTGATGGTGT CTGTGTGGCT CATCCTGGAG GCCCCAGGCA CCAGGAGGTA TACCCTTGCA 
GAGAAGCGGG AAACAGTCAT CCTAAAATGC AATGTCAAAG ATTCCAGCAT GTTGATCTCT 
CTTACCTACG ATGTGATCCT GGTGATCTTA TGCACTGTGT ACGCCTTCAA AACGCGGAAG 
TGCCCAGAAA ATTTCAACGA AGCTAAGTTC ATAGGTTTTA CCATGTACAC CACGTGCATC 
ATCTGGTTGG CCTTCCTCCC TATATTTTAT GTGACATCAA GTGACTACAG AGTGCAGACG 
ACAACCATGT GCATCTCTGT CAGCCTGAGT GGCTTTGTGG TCTTGGGCTG TTTGTTTGCA 
CCCAAGGTTC ACATCATCCT GTTTCAACCC CAGAAGAATG TTGTCACACA CAGACTGCAC 
CTCAACAGGT TCAGTGTCAG TGGAACTGGG ACCACATACT CTCAGTCCTC TGCAAGCACG 
TATGTGCCAA CGGTGTGCAA TGGGCGGGAA GTCCTCGACT CCACCACCTC ATCTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GRM3 ( NM_001363522.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001350451.1 Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu58121
Clone ID Related Accession (Same CDS sequence)	XM_011516088.1 , NM_001363522.1
Accession Version	NM_001363522.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1614bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	metabotropic glutamate receptor 3 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC374499.1, BC041407.1 and DQ315361.1. On May 24, 2018 this sequence version replaced XM_011516088.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.136373.1, SRR1803616.259114.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END##

ATGAAGATGT TGACAAGACT GCAAGTTCTT ACCTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GGGACCATAA CTTTCTAAGG AGAGAGATTA AAATAGAAGG TGACCTTGTT 
TTAGGGGGCC TGTTTCCTAT TAACGAAAAA GGCACTGGAA CTGAAGAATG TGGGCGAATC 
AATGAAGACC GAGGGATTCA ACGCCTGGAA GCCATGTTGT TTGCTATTGA TGAAATCAAC 
AAAGATGATT ACTTGCTACC AGGAGTGAAG TTGGGTGTTC ACATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTGGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACAAAAGTG 
GATGAAGCTG AGTATATGTG TCCTGATGGA TCCTATGCCA TTCAAGAAAA CATCCCACTT 
CTCATTGCAG GGGTCATTGG TGGCTCTTAT AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGCGGCTCT TCCAGATCCC TCAGATCAGC TACGCATCCA CCAGCGCCAA ACTCAGTGAT 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCCG ACTTCTACCA GGCCAAAGCC 
ATGGCTGAGA TCTTGCGCTT CTTCAACTGG ACCTACGTGT CCACAGTAGC CTCCGAGGGT 
GATTACGGGG AGACAGGGAT CGAGGCCTTC GAGCAGGAAG CCCGCCTGCG CAACATCTGC 
ATCGCTACGG CGGAGAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATC 
CGAGAACTGT TGCAGAAGCC CAACGCGCGC GTCGTGGTCC TCTTCATGCG CAGCGACGAC 
TCGCGGGAGC TCATTGCAGC CGCCAGCCGC GCCAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GCGCGCAGGA GAGCATCATC AAGGGCAGCG AGCATGTGGC CTACGGCGCC 
ATCACCCTGG AGCTGGCCTC CCAGCCTGTC CGCCAGTTCG ACCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAACCACCG CAACCCCTGG TTCCGGGACT TCTGGGAGCA AAAGTTTCAG 
TGCAGCCTCC AGAACAAACG CAACCACAGG CGCGTCTGCG ACAAGCACCT GGCCATCGAC 
AGCAGCAACT ACGAGCAAGA GTCCAAGATC ATGTTTGTGG TGAACGCGGT GTATGCCATG 
GCCCACGCTT TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACTACCAA GCTTTGTGAT 
GCTATGAAGA TCCTGGATGG GAAGAAGTTG TACAAGGATT ACTTGCTGAA AATCAACTTC 
ACGGGTGCAG ACGACAACCA TGTGCATCTC TGTCAGCCTG AGTGGCTTTG TGGTCTTGGG 
CTGTTTGTTT GCACCCAAGG TTCACATCAT CCTGTTTCAA CCCCAGAAGA ATGTTGTCAC 
ACACAGACTG CACCTCAACA GGTTCAGTGT CAGTGGAACT GGGACCACAT ACTCTCAGTC 
CTCTGCAAGC ACGTATGTGC CAACGGTGTG CAATGGGCGG GAAGTCCTCG ACTCCACCAC 
CTCATCTCTG TGATTGTGAA TTGCAGTTCA GTTCTTGTGT TTTTAGACTG TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350451.1
CDS	1105..2718
Translation	MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTGADDNHVHLCQPEWLCGLGLFVCTQGSHHPVSTPEECCHTQTAPQQVQCQWNWDHILSVLCKHVCANGVQWAGSPRLHHLISVIVNCSSVLVFLDC

Target ORF information:

RefSeq Version	NM_001363522.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363522.1

ORF Insert Sequence:

ATGAAGATGT TGACAAGACT GCAAGTTCTT ACCTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GGGACCATAA CTTTCTAAGG AGAGAGATTA AAATAGAAGG TGACCTTGTT 
TTAGGGGGCC TGTTTCCTAT TAACGAAAAA GGCACTGGAA CTGAAGAATG TGGGCGAATC 
AATGAAGACC GAGGGATTCA ACGCCTGGAA GCCATGTTGT TTGCTATTGA TGAAATCAAC 
AAAGATGATT ACTTGCTACC AGGAGTGAAG TTGGGTGTTC ACATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTGGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACAAAAGTG 
GATGAAGCTG AGTATATGTG TCCTGATGGA TCCTATGCCA TTCAAGAAAA CATCCCACTT 
CTCATTGCAG GGGTCATTGG TGGCTCTTAT AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGCGGCTCT TCCAGATCCC TCAGATCAGC TACGCATCCA CCAGCGCCAA ACTCAGTGAT 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCCG ACTTCTACCA GGCCAAAGCC 
ATGGCTGAGA TCTTGCGCTT CTTCAACTGG ACCTACGTGT CCACAGTAGC CTCCGAGGGT 
GATTACGGGG AGACAGGGAT CGAGGCCTTC GAGCAGGAAG CCCGCCTGCG CAACATCTGC 
ATCGCTACGG CGGAGAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATC 
CGAGAACTGT TGCAGAAGCC CAACGCGCGC GTCGTGGTCC TCTTCATGCG CAGCGACGAC 
TCGCGGGAGC TCATTGCAGC CGCCAGCCGC GCCAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GCGCGCAGGA GAGCATCATC AAGGGCAGCG AGCATGTGGC CTACGGCGCC 
ATCACCCTGG AGCTGGCCTC CCAGCCTGTC CGCCAGTTCG ACCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAACCACCG CAACCCCTGG TTCCGGGACT TCTGGGAGCA AAAGTTTCAG 
TGCAGCCTCC AGAACAAACG CAACCACAGG CGCGTCTGCG ACAAGCACCT GGCCATCGAC 
AGCAGCAACT ACGAGCAAGA GTCCAAGATC ATGTTTGTGG TGAACGCGGT GTATGCCATG 
GCCCACGCTT TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACTACCAA GCTTTGTGAT 
GCTATGAAGA TCCTGGATGG GAAGAAGTTG TACAAGGATT ACTTGCTGAA AATCAACTTC 
ACGGGTGCAG ACGACAACCA TGTGCATCTC TGTCAGCCTG AGTGGCTTTG TGGTCTTGGG 
CTGTTTGTTT GCACCCAAGG TTCACATCAT CCTGTTTCAA CCCCAGAAGA ATGTTGTCAC 
ACACAGACTG CACCTCAACA GGTTCAGTGT CAGTGGAACT GGGACCACAT ACTCTCAGTC 
CTCTGCAAGC ACGTATGTGC CAACGGTGTG CAATGGGCGG GAAGTCCTCG ACTCCACCAC 
CTCATCTCTG TGATTGTGAA TTGCAGTTCA GTTCTTGTGT TTTTAGACTG TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GRM3 ( XM_011516088.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011514390.1 Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript variant X1, mRNA.

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CloneID	OHu58121
Clone ID Related Accession (Same CDS sequence)	XM_011516088.1 , NM_001363522.1
Accession Version	XM_011516088.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1614bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	metabotropic glutamate receptor 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGATGT TGACAAGACT GCAAGTTCTT ACCTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GGGACCATAA CTTTCTAAGG AGAGAGATTA AAATAGAAGG TGACCTTGTT 
TTAGGGGGCC TGTTTCCTAT TAACGAAAAA GGCACTGGAA CTGAAGAATG TGGGCGAATC 
AATGAAGACC GAGGGATTCA ACGCCTGGAA GCCATGTTGT TTGCTATTGA TGAAATCAAC 
AAAGATGATT ACTTGCTACC AGGAGTGAAG TTGGGTGTTC ACATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTGGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACAAAAGTG 
GATGAAGCTG AGTATATGTG TCCTGATGGA TCCTATGCCA TTCAAGAAAA CATCCCACTT 
CTCATTGCAG GGGTCATTGG TGGCTCTTAT AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGCGGCTCT TCCAGATCCC TCAGATCAGC TACGCATCCA CCAGCGCCAA ACTCAGTGAT 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCCG ACTTCTACCA GGCCAAAGCC 
ATGGCTGAGA TCTTGCGCTT CTTCAACTGG ACCTACGTGT CCACAGTAGC CTCCGAGGGT 
GATTACGGGG AGACAGGGAT CGAGGCCTTC GAGCAGGAAG CCCGCCTGCG CAACATCTGC 
ATCGCTACGG CGGAGAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATC 
CGAGAACTGT TGCAGAAGCC CAACGCGCGC GTCGTGGTCC TCTTCATGCG CAGCGACGAC 
TCGCGGGAGC TCATTGCAGC CGCCAGCCGC GCCAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GCGCGCAGGA GAGCATCATC AAGGGCAGCG AGCATGTGGC CTACGGCGCC 
ATCACCCTGG AGCTGGCCTC CCAGCCTGTC CGCCAGTTCG ACCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAACCACCG CAACCCCTGG TTCCGGGACT TCTGGGAGCA AAAGTTTCAG 
TGCAGCCTCC AGAACAAACG CAACCACAGG CGCGTCTGCG ACAAGCACCT GGCCATCGAC 
AGCAGCAACT ACGAGCAAGA GTCCAAGATC ATGTTTGTGG TGAACGCGGT GTATGCCATG 
GCCCACGCTT TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACTACCAA GCTTTGTGAT 
GCTATGAAGA TCCTGGATGG GAAGAAGTTG TACAAGGATT ACTTGCTGAA AATCAACTTC 
ACGGGTGCAG ACGACAACCA TGTGCATCTC TGTCAGCCTG AGTGGCTTTG TGGTCTTGGG 
CTGTTTGTTT GCACCCAAGG TTCACATCAT CCTGTTTCAA CCCCAGAAGA ATGTTGTCAC 
ACACAGACTG CACCTCAACA GGTTCAGTGT CAGTGGAACT GGGACCACAT ACTCTCAGTC 
CTCTGCAAGC ACGTATGTGC CAACGGTGTG CAATGGGCGG GAAGTCCTCG ACTCCACCAC 
CTCATCTCTG TGATTGTGAA TTGCAGTTCA GTTCTTGTGT TTTTAGACTG TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011514390.1
CDS	274..1887
Translation	MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTGADDNHVHLCQPEWLCGLGLFVCTQGSHHPVSTPEECCHTQTAPQQVQCQWNWDHILSVLCKHVCANGVQWAGSPRLHHLISVIVNCSSVLVFLDC

Target ORF information:

RefSeq Version	XM_011516088.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011516088.1

ORF Insert Sequence:

ATGAAGATGT TGACAAGACT GCAAGTTCTT ACCTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GGGACCATAA CTTTCTAAGG AGAGAGATTA AAATAGAAGG TGACCTTGTT 
TTAGGGGGCC TGTTTCCTAT TAACGAAAAA GGCACTGGAA CTGAAGAATG TGGGCGAATC 
AATGAAGACC GAGGGATTCA ACGCCTGGAA GCCATGTTGT TTGCTATTGA TGAAATCAAC 
AAAGATGATT ACTTGCTACC AGGAGTGAAG TTGGGTGTTC ACATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTGGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACAAAAGTG 
GATGAAGCTG AGTATATGTG TCCTGATGGA TCCTATGCCA TTCAAGAAAA CATCCCACTT 
CTCATTGCAG GGGTCATTGG TGGCTCTTAT AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGCGGCTCT TCCAGATCCC TCAGATCAGC TACGCATCCA CCAGCGCCAA ACTCAGTGAT 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCCG ACTTCTACCA GGCCAAAGCC 
ATGGCTGAGA TCTTGCGCTT CTTCAACTGG ACCTACGTGT CCACAGTAGC CTCCGAGGGT 
GATTACGGGG AGACAGGGAT CGAGGCCTTC GAGCAGGAAG CCCGCCTGCG CAACATCTGC 
ATCGCTACGG CGGAGAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATC 
CGAGAACTGT TGCAGAAGCC CAACGCGCGC GTCGTGGTCC TCTTCATGCG CAGCGACGAC 
TCGCGGGAGC TCATTGCAGC CGCCAGCCGC GCCAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GCGCGCAGGA GAGCATCATC AAGGGCAGCG AGCATGTGGC CTACGGCGCC 
ATCACCCTGG AGCTGGCCTC CCAGCCTGTC CGCCAGTTCG ACCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAACCACCG CAACCCCTGG TTCCGGGACT TCTGGGAGCA AAAGTTTCAG 
TGCAGCCTCC AGAACAAACG CAACCACAGG CGCGTCTGCG ACAAGCACCT GGCCATCGAC 
AGCAGCAACT ACGAGCAAGA GTCCAAGATC ATGTTTGTGG TGAACGCGGT GTATGCCATG 
GCCCACGCTT TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACTACCAA GCTTTGTGAT 
GCTATGAAGA TCCTGGATGG GAAGAAGTTG TACAAGGATT ACTTGCTGAA AATCAACTTC 
ACGGGTGCAG ACGACAACCA TGTGCATCTC TGTCAGCCTG AGTGGCTTTG TGGTCTTGGG 
CTGTTTGTTT GCACCCAAGG TTCACATCAT CCTGTTTCAA CCCCAGAAGA ATGTTGTCAC 
ACACAGACTG CACCTCAACA GGTTCAGTGT CAGTGGAACT GGGACCACAT ACTCTCAGTC 
CTCTGCAAGC ACGTATGTGC CAACGGTGTG CAATGGGCGG GAAGTCCTCG ACTCCACCAC 
CTCATCTCTG TGATTGTGAA TTGCAGTTCA GTTCTTGTGT TTTTAGACTG TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GRM3 ( XM_017012073.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016867562.1 Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu97191
Clone ID Related Accession (Same CDS sequence)	XM_017012073.2 , XM_017012073.1
Accession Version	XM_017012073.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1440bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	metabotropic glutamate receptor 3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017012073.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGATGT TGACAAGACT GCAAGTTCTT ACCTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GGGACCATAA CTTTCTAAGG AGAGAGATTA AAATAGAAGG TGACCTTGTT 
TTAGGGGGCC TGTTTCCTAT TAACGAAAAA GGCACTGGAA CTGAAGAATG TGGGCGAATC 
AATGAAGACC GAGGGATTCA ACGCCTGGAA GCCATGTTGT TTGCTATTGA TGAAATCAAC 
AAAGATGATT ACTTGCTACC AGGAGTGAAG TTGGGTGTTC ACATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTGGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACAAAAGTG 
GATGAAGCTG AGTATATGTG TCCTGATGGA TCCTATGCCA TTCAAGAAAA CATCCCACTT 
CTCATTGCAG GGGTCATTGG TGGCTCTTAT AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGCGGCTCT TCCAGATCCC TCAGATCAGC TACGCATCCA CCAGCGCCAA ACTCAGTGAT 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCCG ACTTCTACCA GGCCAAAGCC 
ATGGCTGAGA TCTTGCGCTT CTTCAACTGG ACCTACGTGT CCACAGTAGC CTCCGAGGGT 
GATTACGGGG AGACAGGGAT CGAGGCCTTC GAGCAGGAAG CCCGCCTGCG CAACATCTGC 
ATCGCTACGG CGGAGAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATC 
CGAGAACTGT TGCAGAAGCC CAACGCGCGC GTCGTGGTCC TCTTCATGCG CAGCGACGAC 
TCGCGGGAGC TCATTGCAGC CGCCAGCCGC GCCAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GCGCGCAGGA GAGCATCATC AAGGGCAGCG AGCATGTGGC CTACGGCGCC 
ATCACCCTGG AGCTGGCCTC CCAGCCTGTC CGCCAGTTCG ACCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAACCACCG CAACCCCTGG TTCCGGGACT TCTGGGAGCA AAAGTTTCAG 
TGCAGCCTCC AGAACAAACG CAACCACAGG CGCGTCTGCG ACAAGCACCT GGCCATCGAC 
AGCAGCAACT ACGAGCAAGA GTCCAAGATC ATGTTTGTGG TGAACGCGGT GTATGCCATG 
GCCCACGCTT TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACTACCAA GCTTTGTGAT 
GCTATGAAGA TCCTGGATGG GAAGAAGTTG TACAAGGATT ACTTGCTGAA AATCAACTTC 
ACGGTGAAGA GACAGACTAC TGGGATCAGA GACCTAGAGC CTGGTGGAGA CAGTCCAGCC 
TTCTTCTTAT GTTTACAATT CTCTACACCT GGAAGAGGAG AAGAGGCAGA AAATGGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016867562.1
CDS	479..1918
Translation	MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTVKRQTTGIRDLEPGGDSPAFFLCLQFSTPGRGEEAENG

Target ORF information:

RefSeq Version	XM_017012073.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017012073.2

ORF Insert Sequence:

ATGAAGATGT TGACAAGACT GCAAGTTCTT ACCTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GGGACCATAA CTTTCTAAGG AGAGAGATTA AAATAGAAGG TGACCTTGTT 
TTAGGGGGCC TGTTTCCTAT TAACGAAAAA GGCACTGGAA CTGAAGAATG TGGGCGAATC 
AATGAAGACC GAGGGATTCA ACGCCTGGAA GCCATGTTGT TTGCTATTGA TGAAATCAAC 
AAAGATGATT ACTTGCTACC AGGAGTGAAG TTGGGTGTTC ACATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTGGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACAAAAGTG 
GATGAAGCTG AGTATATGTG TCCTGATGGA TCCTATGCCA TTCAAGAAAA CATCCCACTT 
CTCATTGCAG GGGTCATTGG TGGCTCTTAT AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGCGGCTCT TCCAGATCCC TCAGATCAGC TACGCATCCA CCAGCGCCAA ACTCAGTGAT 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCCG ACTTCTACCA GGCCAAAGCC 
ATGGCTGAGA TCTTGCGCTT CTTCAACTGG ACCTACGTGT CCACAGTAGC CTCCGAGGGT 
GATTACGGGG AGACAGGGAT CGAGGCCTTC GAGCAGGAAG CCCGCCTGCG CAACATCTGC 
ATCGCTACGG CGGAGAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATC 
CGAGAACTGT TGCAGAAGCC CAACGCGCGC GTCGTGGTCC TCTTCATGCG CAGCGACGAC 
TCGCGGGAGC TCATTGCAGC CGCCAGCCGC GCCAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GCGCGCAGGA GAGCATCATC AAGGGCAGCG AGCATGTGGC CTACGGCGCC 
ATCACCCTGG AGCTGGCCTC CCAGCCTGTC CGCCAGTTCG ACCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAACCACCG CAACCCCTGG TTCCGGGACT TCTGGGAGCA AAAGTTTCAG 
TGCAGCCTCC AGAACAAACG CAACCACAGG CGCGTCTGCG ACAAGCACCT GGCCATCGAC 
AGCAGCAACT ACGAGCAAGA GTCCAAGATC ATGTTTGTGG TGAACGCGGT GTATGCCATG 
GCCCACGCTT TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACTACCAA GCTTTGTGAT 
GCTATGAAGA TCCTGGATGG GAAGAAGTTG TACAAGGATT ACTTGCTGAA AATCAACTTC 
ACGGTGAAGA GACAGACTAC TGGGATCAGA GACCTAGAGC CTGGTGGAGA CAGTCCAGCC 
TTCTTCTTAT GTTTACAATT CTCTACACCT GGAAGAGGAG AAGAGGCAGA AAATGGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GRM3 ( XM_017012073.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016867562.1 Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu97191
Clone ID Related Accession (Same CDS sequence)	XM_017012073.2 , XM_017012073.1
Accession Version	XM_017012073.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1440bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	metabotropic glutamate receptor 3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGATGT TGACAAGACT GCAAGTTCTT ACCTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GGGACCATAA CTTTCTAAGG AGAGAGATTA AAATAGAAGG TGACCTTGTT 
TTAGGGGGCC TGTTTCCTAT TAACGAAAAA GGCACTGGAA CTGAAGAATG TGGGCGAATC 
AATGAAGACC GAGGGATTCA ACGCCTGGAA GCCATGTTGT TTGCTATTGA TGAAATCAAC 
AAAGATGATT ACTTGCTACC AGGAGTGAAG TTGGGTGTTC ACATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTGGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACAAAAGTG 
GATGAAGCTG AGTATATGTG TCCTGATGGA TCCTATGCCA TTCAAGAAAA CATCCCACTT 
CTCATTGCAG GGGTCATTGG TGGCTCTTAT AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGCGGCTCT TCCAGATCCC TCAGATCAGC TACGCATCCA CCAGCGCCAA ACTCAGTGAT 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCCG ACTTCTACCA GGCCAAAGCC 
ATGGCTGAGA TCTTGCGCTT CTTCAACTGG ACCTACGTGT CCACAGTAGC CTCCGAGGGT 
GATTACGGGG AGACAGGGAT CGAGGCCTTC GAGCAGGAAG CCCGCCTGCG CAACATCTGC 
ATCGCTACGG CGGAGAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATC 
CGAGAACTGT TGCAGAAGCC CAACGCGCGC GTCGTGGTCC TCTTCATGCG CAGCGACGAC 
TCGCGGGAGC TCATTGCAGC CGCCAGCCGC GCCAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GCGCGCAGGA GAGCATCATC AAGGGCAGCG AGCATGTGGC CTACGGCGCC 
ATCACCCTGG AGCTGGCCTC CCAGCCTGTC CGCCAGTTCG ACCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAACCACCG CAACCCCTGG TTCCGGGACT TCTGGGAGCA AAAGTTTCAG 
TGCAGCCTCC AGAACAAACG CAACCACAGG CGCGTCTGCG ACAAGCACCT GGCCATCGAC 
AGCAGCAACT ACGAGCAAGA GTCCAAGATC ATGTTTGTGG TGAACGCGGT GTATGCCATG 
GCCCACGCTT TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACTACCAA GCTTTGTGAT 
GCTATGAAGA TCCTGGATGG GAAGAAGTTG TACAAGGATT ACTTGCTGAA AATCAACTTC 
ACGGTGAAGA GACAGACTAC TGGGATCAGA GACCTAGAGC CTGGTGGAGA CAGTCCAGCC 
TTCTTCTTAT GTTTACAATT CTCTACACCT GGAAGAGGAG AAGAGGCAGA AAATGGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016867562.1
CDS	274..1713
Translation	MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTVKRQTTGIRDLEPGGDSPAFFLCLQFSTPGRGEEAENG

Target ORF information:

RefSeq Version	XM_017012073.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glutamate metabotropic receptor 3 (GRM3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017012073.1

ORF Insert Sequence:

ATGAAGATGT TGACAAGACT GCAAGTTCTT ACCTTAGCTT TGTTTTCAAA GGGATTTTTA 
CTCTCTTTAG GGGACCATAA CTTTCTAAGG AGAGAGATTA AAATAGAAGG TGACCTTGTT 
TTAGGGGGCC TGTTTCCTAT TAACGAAAAA GGCACTGGAA CTGAAGAATG TGGGCGAATC 
AATGAAGACC GAGGGATTCA ACGCCTGGAA GCCATGTTGT TTGCTATTGA TGAAATCAAC 
AAAGATGATT ACTTGCTACC AGGAGTGAAG TTGGGTGTTC ACATTTTGGA TACATGTTCA 
AGGGATACCT ATGCATTGGA GCAATCACTG GAGTTTGTCA GGGCATCTTT GACAAAAGTG 
GATGAAGCTG AGTATATGTG TCCTGATGGA TCCTATGCCA TTCAAGAAAA CATCCCACTT 
CTCATTGCAG GGGTCATTGG TGGCTCTTAT AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGCGGCTCT TCCAGATCCC TCAGATCAGC TACGCATCCA CCAGCGCCAA ACTCAGTGAT 
AAGTCGCGCT ATGATTACTT TGCCAGGACC GTGCCCCCCG ACTTCTACCA GGCCAAAGCC 
ATGGCTGAGA TCTTGCGCTT CTTCAACTGG ACCTACGTGT CCACAGTAGC CTCCGAGGGT 
GATTACGGGG AGACAGGGAT CGAGGCCTTC GAGCAGGAAG CCCGCCTGCG CAACATCTGC 
ATCGCTACGG CGGAGAAGGT GGGCCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATC 
CGAGAACTGT TGCAGAAGCC CAACGCGCGC GTCGTGGTCC TCTTCATGCG CAGCGACGAC 
TCGCGGGAGC TCATTGCAGC CGCCAGCCGC GCCAATGCCT CCTTCACCTG GGTGGCCAGC 
GACGGCTGGG GCGCGCAGGA GAGCATCATC AAGGGCAGCG AGCATGTGGC CTACGGCGCC 
ATCACCCTGG AGCTGGCCTC CCAGCCTGTC CGCCAGTTCG ACCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAACCACCG CAACCCCTGG TTCCGGGACT TCTGGGAGCA AAAGTTTCAG 
TGCAGCCTCC AGAACAAACG CAACCACAGG CGCGTCTGCG ACAAGCACCT GGCCATCGAC 
AGCAGCAACT ACGAGCAAGA GTCCAAGATC ATGTTTGTGG TGAACGCGGT GTATGCCATG 
GCCCACGCTT TGCACAAAAT GCAGCGCACC CTCTGTCCCA ACACTACCAA GCTTTGTGAT 
GCTATGAAGA TCCTGGATGG GAAGAAGTTG TACAAGGATT ACTTGCTGAA AATCAACTTC 
ACGGTGAAGA GACAGACTAC TGGGATCAGA GACCTAGAGC CTGGTGGAGA CAGTCCAGCC 
TTCTTCTTAT GTTTACAATT CTCTACACCT GGAAGAGGAG AAGAGGCAGA AAATGGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling.
Pigment cell & melanoma research31(1)115-119(2018 Jan)
Neto A,Ceol CJ

A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding.
Journal of psychopharmacology (Oxford, England)31(12)1519-1526(2017 Dec)
Garc?a-Bea A,Bermudez I,Harrison PJ,Lane TA

Meta-analysis supports GWAS-implicated link between GRM3 and schizophrenia risk.
Translational psychiatry7(8)e1196(2017 Aug)
Saini SM,Mancuso SG,Mostaid MS,Liu C,Pantelis C,Everall IP,Bousman CA

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GRM3 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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