DNAJC15 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DNAJC15
Entrez Gene ID	29103
Full Name	DnaJ heat shock protein family (Hsp40) member C15
Synonyms	DNAJD1,HSD18,MCJ
General protein information	Preferred Names DnaJ heat shock protein family (Hsp40) member C15 Names dnaJ homolog subfamily C member 15 DNAJ domain-containing DnaJ (Hsp40) homolog, subfamily C, member 15 DnaJ (Hsp40) homolog, subfamily D, member 1 cell growth-inhibiting gene 22 protein methylation-controlled J protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q14.11
Disorder MIM:	615339

mRNA and Protein(s)

mRNA	Protein	Name
NM_013238.3	NP_037370.2	dnaJ homolog subfamily C member 15
NM_013238.2	NP_037370.2	dnaJ homolog subfamily C member 15

Pathways from BioSystems

Homologies

Homo sapiens (human)	DNAJC15	NP_037370.2
Bos taurus (cattle)	DNAJC15	NP_001073801.1
Oryza sativa (rice)	Os03g0776900	NP_001051437.1
Canis lupus familiaris (dog)	DNAJC15	XP_534131.1
Mus musculus (house mouse)	Dnajc15	NP_079660.1
Rattus norvegicus (Norway rat)	Dnajc15	NP_001099520.1
Pan troglodytes (chimpanzee)	DNAJC15	XP_509654.1
	DNAJC15	XP_001092902.1
Xenopus tropicalis (tropical clawed frog)	dnajc15	NP_001005145.1
Gallus gallus (chicken)	DNAJC15	NP_001264705.1
Danio rerio (zebrafish)	dnajc15	NP_001003476.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide comparison of allele-specific gene expression between African and European populations.
Tian L, Khan A, Ning Z, Yuan K, Zhang C, Lou H, Yuan Y, Xu S
Human molecular genetics(2018 Jan)

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.
Barbier-Torres L, Iruzubieta P, Fern?ndez-Ramos D, Delgado TC, Taibo D, Guiti?rrez-de-Juan V, Varela-Rey M, Azkargorta M, Navasa N, Fern?ndez-Tussy P, Zubiete-Franco I, Simon J, Lopitz-Otsoa F, Lachiondo-Ortega S, Crespo J, Masson S, McCain MV, Villa E, Reeves H, Elortza F, Lucena MI, Hern?ndez-Alvarez MI, Zorzano A, Andrade RJ, Lu SC, Mato JM, Anguita J, Rinc?n M, Mart?nez-Chantar ML
Nature communications8(1)2068(2017 Dec)

Functional Diversity of Human Mitochondrial J-proteins Is Independent of Their Association with the Inner Membrane Presequence Translocase.
Sinha D, Srivastava S, D'Silva P
The Journal of biological chemistry291(33)17345-59(2016 08)

Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus.
Champagne DP, Hatle KM, Fortner KA, D'Alessandro A, Thornton TM, Yang R, Torralba D, Tom?s-Cort?zar J, Jun YW, Ahn KH, Hansen KC, Haynes L, Anguita J, Rincon M
Immunity44(6)1299-311(2016 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Both DnaJC15 and DnaJC19 formed two distinct subcomplexes with Magmas at the import channel.
Title: Functional Diversity of Human Mitochondrial J-proteins Is Independent of Their Association with the Inner Membrane Presequence Translocase.

this study shows that memory CD8+ T cells lacking MCJ provide superior protection against influenza virus infection
Title: Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus.

These results identify the MCJ gene as a transcriptional target of IFNgamma and provide evidence of the dynamic adaptation of normal tissues to changes in the environment as a way to adapt metabolically to new conditions
Title: Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages.

Changes in the expression levels of IRS1, IRS2, RIPK2, RSPO1, and DNA JC15 genes might contribute to the development of insulin resistance and glucose intolerance in the obese boys.
Title: The expression of CCN2, IQSEC, RSPO1, DNAJC15, RIPK2, IL13RA2, IRS1, and IRS2 genes in blood of obese boys with insulin resistance.

Report functional connection between mitochondrial inner membrane protein translocation machinery-associated J-protein DnaJC15 and regulation of cell death pathways.
Title: Chaperoning mitochondrial permeability transition: regulation of transition pore complex by a J-protein, DnaJC15.

The following DNAJC15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DNAJC15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12875	NM_013238.3 Latest version!	Homo sapiens DnaJ heat shock protein family (Hsp40) member C15 (DNAJC15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu12875	NM_013238.2	Homo sapiens DnaJ heat shock protein family (Hsp40) member C15 (DNAJC15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DNAJC15 ( NM_013238.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_037370.2 Homo sapiens DnaJ heat shock protein family (Hsp40) member C15 (DNAJC15), mRNA.

Price & Availability↑

CloneID	OHu12875
Clone ID Related Accession (Same CDS sequence)	NM_013238.3 , NM_013238.2
Accession Version	NM_013238.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	dnaJ homolog subfamily C member 15
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF126743.1, AL445217.3 and CA444534.1. On May 17, 2019 this sequence version replaced NM_013238.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.2533127.1, SRR7346977.2736747.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000379221.4/ ENSP00000368523.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCCC GTGGTGTCAT CGCTCCAGTT GGCGAGAGTT TGCGCTACGC TGAGTACTTG 
CAGCCCTCGG CCAAACGGCC AGACGCCGAC GTCGACCAGC AGAGACTGGT AAGAAGTTTG 
ATAGCTGTAG GACTGGGTGT TGCAGCTCTT GCATTTGCAG GTCGCTACGC ATTTCGGATC 
TGGAAACCTC TAGAACAAGT TATCACAGAA ACTGCAAAGA AGATTTCAAC TCCTAGCTTT 
TCATCCTACT ATAAAGGAGG ATTTGAACAG AAAATGAGTA GGCGAGAAGC TGGTCTTATT 
TTAGGTGTAA GCCCATCTGC TGGCAAGGCT AAGATTAGAA CAGCTCATAG GAGAGTCATG 
ATTTTGAATC ACCCAGATAA AGGTGGATCT CCTTACGTAG CAGCCAAAAT AAATGAAGCA 
AAAGACTTGC TAGAAACAAC CACCAAACAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037370.2
CDS	42..494
Translation	MAARGVIAPVGESLRYAEYLQPSAKRPDADVDQQRLVRSLIAVGLGVAALAFAGRYAFRIWKPLEQVITETAKKISTPSFSSYYKGGFEQKMSRREAGLILGVSPSAGKAKIRTAHRRVMILNHPDKGGSPYVAAKINEAKDLLETTTKH

Target ORF information:

RefSeq Version	NM_013238.3
Organism	Homo sapiens(human)
Definition	Homo sapiens DnaJ heat shock protein family (Hsp40) member C15 (DNAJC15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013238.3

ORF Insert Sequence:

ATGGCTGCCC GTGGTGTCAT CGCTCCAGTT GGCGAGAGTT TGCGCTACGC TGAGTACTTG 
CAGCCCTCGG CCAAACGGCC AGACGCCGAC GTCGACCAGC AGAGACTGGT AAGAAGTTTG 
ATAGCTGTAG GACTGGGTGT TGCAGCTCTT GCATTTGCAG GTCGCTACGC ATTTCGGATC 
TGGAAACCTC TAGAACAAGT TATCACAGAA ACTGCAAAGA AGATTTCAAC TCCTAGCTTT 
TCATCCTACT ATAAAGGAGG ATTTGAACAG AAAATGAGTA GGCGAGAAGC TGGTCTTATT 
TTAGGTGTAA GCCCATCTGC TGGCAAGGCT AAGATTAGAA CAGCTCATAG GAGAGTCATG 
ATTTTGAATC ACCCAGATAA AGGTGGATCT CCTTACGTAG CAGCCAAAAT AAATGAAGCA 
AAAGACTTGC TAGAAACAAC CACCAAACAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNAJC15 ( NM_013238.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_037370.2 Homo sapiens DnaJ heat shock protein family (Hsp40) member C15 (DNAJC15), mRNA.

Price & Availability↑

CloneID	OHu12875
Clone ID Related Accession (Same CDS sequence)	NM_013238.3 , NM_013238.2
Accession Version	NM_013238.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	dnaJ homolog subfamily C member 15
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF126743.1, AL445217.3 and CA444534.1. On May 24, 2005 this sequence version replaced NM_013238.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY248898.1, SRR1803615.236097.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCCC GTGGTGTCAT CGCTCCAGTT GGCGAGAGTT TGCGCTACGC TGAGTACTTG 
CAGCCCTCGG CCAAACGGCC AGACGCCGAC GTCGACCAGC AGAGACTGGT AAGAAGTTTG 
ATAGCTGTAG GACTGGGTGT TGCAGCTCTT GCATTTGCAG GTCGCTACGC ATTTCGGATC 
TGGAAACCTC TAGAACAAGT TATCACAGAA ACTGCAAAGA AGATTTCAAC TCCTAGCTTT 
TCATCCTACT ATAAAGGAGG ATTTGAACAG AAAATGAGTA GGCGAGAAGC TGGTCTTATT 
TTAGGTGTAA GCCCATCTGC TGGCAAGGCT AAGATTAGAA CAGCTCATAG GAGAGTCATG 
ATTTTGAATC ACCCAGATAA AGGTGGATCT CCTTACGTAG CAGCCAAAAT AAATGAAGCA 
AAAGACTTGC TAGAAACAAC CACCAAACAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037370.2
CDS	402..854
Translation	MAARGVIAPVGESLRYAEYLQPSAKRPDADVDQQRLVRSLIAVGLGVAALAFAGRYAFRIWKPLEQVITETAKKISTPSFSSYYKGGFEQKMSRREAGLILGVSPSAGKAKIRTAHRRVMILNHPDKGGSPYVAAKINEAKDLLETTTKH

Target ORF information:

RefSeq Version	NM_013238.2
Organism	Homo sapiens(human)
Definition	Homo sapiens DnaJ heat shock protein family (Hsp40) member C15 (DNAJC15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013238.2

ORF Insert Sequence:

ATGGCTGCCC GTGGTGTCAT CGCTCCAGTT GGCGAGAGTT TGCGCTACGC TGAGTACTTG 
CAGCCCTCGG CCAAACGGCC AGACGCCGAC GTCGACCAGC AGAGACTGGT AAGAAGTTTG 
ATAGCTGTAG GACTGGGTGT TGCAGCTCTT GCATTTGCAG GTCGCTACGC ATTTCGGATC 
TGGAAACCTC TAGAACAAGT TATCACAGAA ACTGCAAAGA AGATTTCAAC TCCTAGCTTT 
TCATCCTACT ATAAAGGAGG ATTTGAACAG AAAATGAGTA GGCGAGAAGC TGGTCTTATT 
TTAGGTGTAA GCCCATCTGC TGGCAAGGCT AAGATTAGAA CAGCTCATAG GAGAGTCATG 
ATTTTGAATC ACCCAGATAA AGGTGGATCT CCTTACGTAG CAGCCAAAAT AAATGAAGCA 
AAAGACTTGC TAGAAACAAC CACCAAACAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide comparison of allele-specific gene expression between African and European populations.
Human molecular genetics(2018 Jan)
Tian L,Khan A,Ning Z,Yuan K,Zhang C,Lou H,Yuan Y,Xu S

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.
Nature communications8(1)2068(2017 Dec)
Barbier-Torres L,Iruzubieta P,Fern?ndez-Ramos D,Delgado TC,Taibo D,Guiti?rrez-de-Juan V,Varela-Rey M,Azkargorta M,Navasa N,Fern?ndez-Tussy P,Zubiete-Franco I,Simon J,Lopitz-Otsoa F,Lachiondo-Ortega S,Crespo J,Masson S,McCain MV,Villa E,Reeves H,Elortza F,Lucena MI,Hern?ndez-Alvarez MI,Zorzano A,Andrade RJ,Lu SC,Mato JM,Anguita J,Rinc?n M,Mart?nez-Chantar ML

Functional Diversity of Human Mitochondrial J-proteins Is Independent of Their Association with the Inner Membrane Presequence Translocase.
The Journal of biological chemistry291(33)17345-59(2016 08)
Sinha D,Srivastava S,D'Silva P

Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus.
Immunity44(6)1299-311(2016 06)
Champagne DP,Hatle KM,Fortner KA,D'Alessandro A,Thornton TM,Yang R,Torralba D,Tom?s-Cort?zar J,Jun YW,Ahn KH,Hansen KC,Haynes L,Anguita J,Rincon M

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DNAJC15 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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