C1GALT1C1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	C1GALT1C1
Entrez Gene ID	29071
Full Name	C1GALT1 specific chaperone 1
Synonyms	C1GALT2,C38H2-L1,COSMC,HSPC067,MST143,TNPS
General protein information	Preferred Names C1GALT1 specific chaperone 1 Names C1GALT1-specific chaperone 1 C38H2-like protein 1 beta 1,3-galactosyltransferase 2 core 1 beta1,3-galactosyltransferase 2 core 1 beta3-Gal-T2 core 1 beta3-galactosyltransferase-specific molecular chaperone
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq24
Summary	This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2009].
Disorder MIM:	300611
Disorder Html:	Tn polyagglutination syndrome, somatic, 300622 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001011551.3	NP_001011551.1	C1GALT1-specific chaperone 1
NM_001011551.2	NP_001011551.1	C1GALT1-specific chaperone 1
NM_152692.4	NP_689905.1	C1GALT1-specific chaperone 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	C1GALT1C1	NP_689905.1
Canis lupus familiaris (dog)	C1GALT1C1	XP_003435708.1
Bos taurus (cattle)	C1GALT1C1	NP_001029747.1
	C1GALT1C1	XP_001086671.1
Xenopus tropicalis (tropical clawed frog)	c1galt1c1	NP_001004886.1
Pan troglodytes (chimpanzee)	C1GALT1C1	XP_003317707.1
Gallus gallus (chicken)	C1GALT1C1	NP_001264718.1
Danio rerio (zebrafish)	c1galt1c1	NP_955961.1
Mus musculus (house mouse)	C1galt1c1	NP_067525.1
Rattus norvegicus (Norway rat)	C1galt1c1	NP_001025204.1

Gene Ontology
Bibliography

Related articles in PubMed

CD3/CD28 dynabeads induce expression of tn antigen in human t cells accompanied by hypermethylation of the cosmc promoter.
Shi C, Xu X, Yu X, Du Z, Luan X, Liu D, Hu T
Molecular immunology9098-105(2017 Oct)

GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway.
Kiryluk K, Li Y, Moldoveanu Z, Suzuki H, Reily C, Hou P, Xie J, Mladkova N, Prakash S, Fischman C, Shapiro S, LeDesma RA, Bradbury D, Ionita-Laza I, Eitner F, Rauen T, Maillard N, Berthoux F, Floege J, Chen N, Zhang H, Scolari F, Wyatt RJ, Julian BA, Gharavi AG, Novak J
PLoS genetics13(2)e1006609(2017 Feb)

TGF-?1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 ?1, 3-galactosyltransferase and Cosmc.
Xiao J, Wang M, Xiong D, Wang Y, Li Q, Zhou J, Chen Q
Molecular medicine reports15(2)969-974(2017 Feb)

Biochemical characterization of functional domains of the chaperone Cosmc.
Hanes MS, Moremen KW, Cummings RD
PloS one12(6)e0180242(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The data suggest that hypermethylation of the Cosmc promoter may induce the expression of Tn antigen in activated T cells.
Title: CD3/CD28 dynabeads induce expression of tn antigen in human t cells accompanied by hypermethylation of the cosmc promoter.

Data indicate that mRNA levels of both core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 (C1GALT1) and C1GALT1-specific chaperone 1 protein (C1GALT1C1) determine the rate of secretion of galactose-deficient IgA1 (Gd-IgA1) in IgA1-producing cells.
Title: GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway.

The terminal glycosylation of secreted IgA1 was altered in response to TGFbeta1. TGFbeta1 stimulation significantly decreased the mRNA levels of C1GalT1 and Cosmc. TGFbeta1 may be key in controlling the glycosylation of IgA1, in part via the downregulation of C1GalT1 and Cosmc.
Title: TGF-?1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 ?1, 3-galactosyltransferase and Cosmc.

results provide new structure-function insight to Cosmc, indicate that Cosmc behaves as a modular protein and suggests points of modulation or regulation of in vivo chaperone function
Title: Biochemical characterization of functional domains of the chaperone Cosmc.

mutations c.393T>A and c.72A>G in the exon region of Cosmc gene in children with Henoch-Schonlein purpura (HSP) are not associated with the onset of Henoch-Schonlein purpura
Title: [Association of Cosmc gene mutation with susceptibility to Henoch-Sch?nlein purpura in children].

The following C1GALT1C1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C1GALT1C1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20001	NM_001011551.3 Latest version!	Homo sapiens C1GALT1 specific chaperone 1 (C1GALT1C1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu20001	NM_152692.4 Latest version!	Homo sapiens C1GALT1 specific chaperone 1 (C1GALT1C1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu20001	NM_001011551.2	Homo sapiens C1GALT1 specific chaperone 1 (C1GALT1C1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C1GALT1C1 ( NM_001011551.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001011551.1 Homo sapiens C1GALT1 specific chaperone 1 (C1GALT1C1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20001
Clone ID Related Accession (Same CDS sequence)	NM_001011551.3 , NM_001011551.2 , NM_152692.4
Accession Version	NM_001011551.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	C1GALT1-specific chaperone 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ238398.1, BC050441.1, AY358642.1 and BM971206.1. On Nov 22, 2018 this sequence version replaced NM_001011551.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189658.135181.1, SRR1803616.143900.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000304661.6/ ENSP00000304364.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTTTCTG AAAGCAGCTC CTTTTTGAAG GGTGTGATGC TTGGAAGCAT TTTCTGTGCT 
TTGATCACTA TGCTAGGACA CATTAGGATT GGTCATGGAA ATAGAATGCA CCACCATGAG 
CATCATCACC TACAAGCTCC TAACAAAGAA GATATCTTGA AAATTTCAGA GGATGAGCGC 
ATGGAGCTCA GTAAGAGCTT TCGAGTATAC TGTATTATCC TTGTAAAACC CAAAGATGTG 
AGTCTTTGGG CTGCAGTAAA GGAGACTTGG ACCAAACACT GTGACAAAGC AGAGTTCTTC 
AGTTCTGAAA ATGTTAAAGT GTTTGAGTCA ATTAATATGG ACACAAATGA CATGTGGTTA 
ATGATGAGAA AAGCTTACAA ATACGCCTTT GATAAGTATA GAGACCAATA CAACTGGTTC 
TTCCTTGCAC GCCCCACTAC GTTTGCTATC ATTGAAAACC TAAAGTATTT TTTGTTAAAA 
AAGGATCCAT CACAGCCTTT CTATCTAGGC CACACTATAA AATCTGGAGA CCTTGAATAT 
GTGGGTATGG AAGGAGGAAT TGTCTTAAGT GTAGAATCAA TGAAAAGACT TAACAGCCTT 
CTCAATATCC CAGAAAAGTG TCCTGAACAG GGAGGGATGA TTTGGAAGAT ATCTGAAGAT 
AAACAGCTAG CAGTTTGCCT GAAATATGCT GGAGTATTTG CAGAAAATGC AGAAGATGCT 
GATGGAAAAG ATGTATTTAA TACCAAATCT GTTGGGCTTT CTATTAAAGA GGCAATGACT 
TATCACCCCA ACCAGGTAGT AGAAGGCTGT TGTTCAGATA TGGCTGTTAC TTTTAATGGA 
CTGACTCCAA ATCAGATGCA TGTGATGATG TATGGGGTAT ACCGCCTTAG GGCATTTGGG 
CATATTTTCA ATGATGCATT GGTTTTCTTA CCTCCAAATG GTTCTGACAA TGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001011551.1
CDS	144..1100
Translation	MLSESSSFLKGVMLGSIFCALITMLGHIRIGHGNRMHHHEHHHLQAPNKEDILKISEDERMELSKSFRVYCIILVKPKDVSLWAAVKETWTKHCDKAEFFSSENVKVFESINMDTNDMWLMMRKAYKYAFDKYRDQYNWFFLARPTTFAIIENLKYFLLKKDPSQPFYLGHTIKSGDLEYVGMEGGIVLSVESMKRLNSLLNIPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDADGKDVFNTKSVGLSIKEAMTYHPNQVVEGCCSDMAVTFNGLTPNQMHVMMYGVYRLRAFGHIFNDALVFLPPNGSDND

Target ORF information:

RefSeq Version	NM_001011551.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C1GALT1 specific chaperone 1 (C1GALT1C1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001011551.3

ORF Insert Sequence:

ATGCTTTCTG AAAGCAGCTC CTTTTTGAAG GGTGTGATGC TTGGAAGCAT TTTCTGTGCT 
TTGATCACTA TGCTAGGACA CATTAGGATT GGTCATGGAA ATAGAATGCA CCACCATGAG 
CATCATCACC TACAAGCTCC TAACAAAGAA GATATCTTGA AAATTTCAGA GGATGAGCGC 
ATGGAGCTCA GTAAGAGCTT TCGAGTATAC TGTATTATCC TTGTAAAACC CAAAGATGTG 
AGTCTTTGGG CTGCAGTAAA GGAGACTTGG ACCAAACACT GTGACAAAGC AGAGTTCTTC 
AGTTCTGAAA ATGTTAAAGT GTTTGAGTCA ATTAATATGG ACACAAATGA CATGTGGTTA 
ATGATGAGAA AAGCTTACAA ATACGCCTTT GATAAGTATA GAGACCAATA CAACTGGTTC 
TTCCTTGCAC GCCCCACTAC GTTTGCTATC ATTGAAAACC TAAAGTATTT TTTGTTAAAA 
AAGGATCCAT CACAGCCTTT CTATCTAGGC CACACTATAA AATCTGGAGA CCTTGAATAT 
GTGGGTATGG AAGGAGGAAT TGTCTTAAGT GTAGAATCAA TGAAAAGACT TAACAGCCTT 
CTCAATATCC CAGAAAAGTG TCCTGAACAG GGAGGGATGA TTTGGAAGAT ATCTGAAGAT 
AAACAGCTAG CAGTTTGCCT GAAATATGCT GGAGTATTTG CAGAAAATGC AGAAGATGCT 
GATGGAAAAG ATGTATTTAA TACCAAATCT GTTGGGCTTT CTATTAAAGA GGCAATGACT 
TATCACCCCA ACCAGGTAGT AGAAGGCTGT TGTTCAGATA TGGCTGTTAC TTTTAATGGA 
CTGACTCCAA ATCAGATGCA TGTGATGATG TATGGGGTAT ACCGCCTTAG GGCATTTGGG 
CATATTTTCA ATGATGCATT GGTTTTCTTA CCTCCAAATG GTTCTGACAA TGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C1GALT1C1 ( NM_001011551.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001011551.1 Homo sapiens C1GALT1 specific chaperone 1 (C1GALT1C1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20001
Clone ID Related Accession (Same CDS sequence)	NM_001011551.3 , NM_001011551.2 , NM_152692.4
Accession Version	NM_001011551.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-12
Organism	Homo sapiens(human)
Product	C1GALT1-specific chaperone 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ238398.1, BC050441.1, AY358642.1 and BM971206.1. On Dec 12, 2009 this sequence version replaced NM_001011551.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ238398.1, SRR1163657.442479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTTTCTG AAAGCAGCTC CTTTTTGAAG GGTGTGATGC TTGGAAGCAT TTTCTGTGCT 
TTGATCACTA TGCTAGGACA CATTAGGATT GGTCATGGAA ATAGAATGCA CCACCATGAG 
CATCATCACC TACAAGCTCC TAACAAAGAA GATATCTTGA AAATTTCAGA GGATGAGCGC 
ATGGAGCTCA GTAAGAGCTT TCGAGTATAC TGTATTATCC TTGTAAAACC CAAAGATGTG 
AGTCTTTGGG CTGCAGTAAA GGAGACTTGG ACCAAACACT GTGACAAAGC AGAGTTCTTC 
AGTTCTGAAA ATGTTAAAGT GTTTGAGTCA ATTAATATGG ACACAAATGA CATGTGGTTA 
ATGATGAGAA AAGCTTACAA ATACGCCTTT GATAAGTATA GAGACCAATA CAACTGGTTC 
TTCCTTGCAC GCCCCACTAC GTTTGCTATC ATTGAAAACC TAAAGTATTT TTTGTTAAAA 
AAGGATCCAT CACAGCCTTT CTATCTAGGC CACACTATAA AATCTGGAGA CCTTGAATAT 
GTGGGTATGG AAGGAGGAAT TGTCTTAAGT GTAGAATCAA TGAAAAGACT TAACAGCCTT 
CTCAATATCC CAGAAAAGTG TCCTGAACAG GGAGGGATGA TTTGGAAGAT ATCTGAAGAT 
AAACAGCTAG CAGTTTGCCT GAAATATGCT GGAGTATTTG CAGAAAATGC AGAAGATGCT 
GATGGAAAAG ATGTATTTAA TACCAAATCT GTTGGGCTTT CTATTAAAGA GGCAATGACT 
TATCACCCCA ACCAGGTAGT AGAAGGCTGT TGTTCAGATA TGGCTGTTAC TTTTAATGGA 
CTGACTCCAA ATCAGATGCA TGTGATGATG TATGGGGTAT ACCGCCTTAG GGCATTTGGG 
CATATTTTCA ATGATGCATT GGTTTTCTTA CCTCCAAATG GTTCTGACAA TGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001011551.1
CDS	240..1196
Translation	MLSESSSFLKGVMLGSIFCALITMLGHIRIGHGNRMHHHEHHHLQAPNKEDILKISEDERMELSKSFRVYCIILVKPKDVSLWAAVKETWTKHCDKAEFFSSENVKVFESINMDTNDMWLMMRKAYKYAFDKYRDQYNWFFLARPTTFAIIENLKYFLLKKDPSQPFYLGHTIKSGDLEYVGMEGGIVLSVESMKRLNSLLNIPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDADGKDVFNTKSVGLSIKEAMTYHPNQVVEGCCSDMAVTFNGLTPNQMHVMMYGVYRLRAFGHIFNDALVFLPPNGSDND

Target ORF information:

RefSeq Version	NM_001011551.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C1GALT1 specific chaperone 1 (C1GALT1C1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001011551.2

ORF Insert Sequence:

ATGCTTTCTG AAAGCAGCTC CTTTTTGAAG GGTGTGATGC TTGGAAGCAT TTTCTGTGCT 
TTGATCACTA TGCTAGGACA CATTAGGATT GGTCATGGAA ATAGAATGCA CCACCATGAG 
CATCATCACC TACAAGCTCC TAACAAAGAA GATATCTTGA AAATTTCAGA GGATGAGCGC 
ATGGAGCTCA GTAAGAGCTT TCGAGTATAC TGTATTATCC TTGTAAAACC CAAAGATGTG 
AGTCTTTGGG CTGCAGTAAA GGAGACTTGG ACCAAACACT GTGACAAAGC AGAGTTCTTC 
AGTTCTGAAA ATGTTAAAGT GTTTGAGTCA ATTAATATGG ACACAAATGA CATGTGGTTA 
ATGATGAGAA AAGCTTACAA ATACGCCTTT GATAAGTATA GAGACCAATA CAACTGGTTC 
TTCCTTGCAC GCCCCACTAC GTTTGCTATC ATTGAAAACC TAAAGTATTT TTTGTTAAAA 
AAGGATCCAT CACAGCCTTT CTATCTAGGC CACACTATAA AATCTGGAGA CCTTGAATAT 
GTGGGTATGG AAGGAGGAAT TGTCTTAAGT GTAGAATCAA TGAAAAGACT TAACAGCCTT 
CTCAATATCC CAGAAAAGTG TCCTGAACAG GGAGGGATGA TTTGGAAGAT ATCTGAAGAT 
AAACAGCTAG CAGTTTGCCT GAAATATGCT GGAGTATTTG CAGAAAATGC AGAAGATGCT 
GATGGAAAAG ATGTATTTAA TACCAAATCT GTTGGGCTTT CTATTAAAGA GGCAATGACT 
TATCACCCCA ACCAGGTAGT AGAAGGCTGT TGTTCAGATA TGGCTGTTAC TTTTAATGGA 
CTGACTCCAA ATCAGATGCA TGTGATGATG TATGGGGTAT ACCGCCTTAG GGCATTTGGG 
CATATTTTCA ATGATGCATT GGTTTTCTTA CCTCCAAATG GTTCTGACAA TGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C1GALT1C1 ( NM_152692.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_689905.1 Homo sapiens C1GALT1 specific chaperone 1 (C1GALT1C1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20001
Clone ID Related Accession (Same CDS sequence)	NM_001011551.3 , NM_001011551.2 , NM_152692.4
Accession Version	NM_152692.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	C1GALT1-specific chaperone 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ238398.1, AY159319.1, AA578739.1 and BM971206.1. This sequence is a reference standard in the RefSeqGene project. On Dec 12, 2009 this sequence version replaced NM_152692.3. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY159319.1, AF161552.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA2151741 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTTTCTG AAAGCAGCTC CTTTTTGAAG GGTGTGATGC TTGGAAGCAT TTTCTGTGCT 
TTGATCACTA TGCTAGGACA CATTAGGATT GGTCATGGAA ATAGAATGCA CCACCATGAG 
CATCATCACC TACAAGCTCC TAACAAAGAA GATATCTTGA AAATTTCAGA GGATGAGCGC 
ATGGAGCTCA GTAAGAGCTT TCGAGTATAC TGTATTATCC TTGTAAAACC CAAAGATGTG 
AGTCTTTGGG CTGCAGTAAA GGAGACTTGG ACCAAACACT GTGACAAAGC AGAGTTCTTC 
AGTTCTGAAA ATGTTAAAGT GTTTGAGTCA ATTAATATGG ACACAAATGA CATGTGGTTA 
ATGATGAGAA AAGCTTACAA ATACGCCTTT GATAAGTATA GAGACCAATA CAACTGGTTC 
TTCCTTGCAC GCCCCACTAC GTTTGCTATC ATTGAAAACC TAAAGTATTT TTTGTTAAAA 
AAGGATCCAT CACAGCCTTT CTATCTAGGC CACACTATAA AATCTGGAGA CCTTGAATAT 
GTGGGTATGG AAGGAGGAAT TGTCTTAAGT GTAGAATCAA TGAAAAGACT TAACAGCCTT 
CTCAATATCC CAGAAAAGTG TCCTGAACAG GGAGGGATGA TTTGGAAGAT ATCTGAAGAT 
AAACAGCTAG CAGTTTGCCT GAAATATGCT GGAGTATTTG CAGAAAATGC AGAAGATGCT 
GATGGAAAAG ATGTATTTAA TACCAAATCT GTTGGGCTTT CTATTAAAGA GGCAATGACT 
TATCACCCCA ACCAGGTAGT AGAAGGCTGT TGTTCAGATA TGGCTGTTAC TTTTAATGGA 
CTGACTCCAA ATCAGATGCA TGTGATGATG TATGGGGTAT ACCGCCTTAG GGCATTTGGG 
CATATTTTCA ATGATGCATT GGTTTTCTTA CCTCCAAATG GTTCTGACAA TGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689905.1
CDS	412..1368
Translation	MLSESSSFLKGVMLGSIFCALITMLGHIRIGHGNRMHHHEHHHLQAPNKEDILKISEDERMELSKSFRVYCIILVKPKDVSLWAAVKETWTKHCDKAEFFSSENVKVFESINMDTNDMWLMMRKAYKYAFDKYRDQYNWFFLARPTTFAIIENLKYFLLKKDPSQPFYLGHTIKSGDLEYVGMEGGIVLSVESMKRLNSLLNIPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDADGKDVFNTKSVGLSIKEAMTYHPNQVVEGCCSDMAVTFNGLTPNQMHVMMYGVYRLRAFGHIFNDALVFLPPNGSDND

Target ORF information:

RefSeq Version	NM_152692.4
Organism	Homo sapiens(human)
Definition	Homo sapiens C1GALT1 specific chaperone 1 (C1GALT1C1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152692.4

ORF Insert Sequence:

ATGCTTTCTG AAAGCAGCTC CTTTTTGAAG GGTGTGATGC TTGGAAGCAT TTTCTGTGCT 
TTGATCACTA TGCTAGGACA CATTAGGATT GGTCATGGAA ATAGAATGCA CCACCATGAG 
CATCATCACC TACAAGCTCC TAACAAAGAA GATATCTTGA AAATTTCAGA GGATGAGCGC 
ATGGAGCTCA GTAAGAGCTT TCGAGTATAC TGTATTATCC TTGTAAAACC CAAAGATGTG 
AGTCTTTGGG CTGCAGTAAA GGAGACTTGG ACCAAACACT GTGACAAAGC AGAGTTCTTC 
AGTTCTGAAA ATGTTAAAGT GTTTGAGTCA ATTAATATGG ACACAAATGA CATGTGGTTA 
ATGATGAGAA AAGCTTACAA ATACGCCTTT GATAAGTATA GAGACCAATA CAACTGGTTC 
TTCCTTGCAC GCCCCACTAC GTTTGCTATC ATTGAAAACC TAAAGTATTT TTTGTTAAAA 
AAGGATCCAT CACAGCCTTT CTATCTAGGC CACACTATAA AATCTGGAGA CCTTGAATAT 
GTGGGTATGG AAGGAGGAAT TGTCTTAAGT GTAGAATCAA TGAAAAGACT TAACAGCCTT 
CTCAATATCC CAGAAAAGTG TCCTGAACAG GGAGGGATGA TTTGGAAGAT ATCTGAAGAT 
AAACAGCTAG CAGTTTGCCT GAAATATGCT GGAGTATTTG CAGAAAATGC AGAAGATGCT 
GATGGAAAAG ATGTATTTAA TACCAAATCT GTTGGGCTTT CTATTAAAGA GGCAATGACT 
TATCACCCCA ACCAGGTAGT AGAAGGCTGT TGTTCAGATA TGGCTGTTAC TTTTAATGGA 
CTGACTCCAA ATCAGATGCA TGTGATGATG TATGGGGTAT ACCGCCTTAG GGCATTTGGG 
CATATTTTCA ATGATGCATT GGTTTTCTTA CCTCCAAATG GTTCTGACAA TGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CD3/CD28 dynabeads induce expression of tn antigen in human t cells accompanied by hypermethylation of the cosmc promoter.
Molecular immunology9098-105(2017 Oct)
Shi C,Xu X,Yu X,Du Z,Luan X,Liu D,Hu T

GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway.
PLoS genetics13(2)e1006609(2017 Feb)
Kiryluk K,Li Y,Moldoveanu Z,Suzuki H,Reily C,Hou P,Xie J,Mladkova N,Prakash S,Fischman C,Shapiro S,LeDesma RA,Bradbury D,Ionita-Laza I,Eitner F,Rauen T,Maillard N,Berthoux F,Floege J,Chen N,Zhang H,Scolari F,Wyatt RJ,Julian BA,Gharavi AG,Novak J

TGF-?1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 ?1, 3-galactosyltransferase and Cosmc.
Molecular medicine reports15(2)969-974(2017 Feb)
Xiao J,Wang M,Xiong D,Wang Y,Li Q,Zhou J,Chen Q

Biochemical characterization of functional domains of the chaperone Cosmc.
PloS one12(6)e0180242(2017)
Hanes MS,Moremen KW,Cummings RD

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C1GALT1C1 cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

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