GRIK3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GRIK3
Entrez Gene ID	2899
Full Name	glutamate ionotropic receptor kainate type subunit 3
Synonyms	EAA5,GLR7,GLUR7,GluK3,GluR7a
General protein information	Preferred Names glutamate ionotropic receptor kainate type subunit 3 Names glutamate receptor ionotropic, kainate 3 dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7)) excitatory amino acid receptor 5 gluR-7 glutamate receptor 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p34.3
Summary	Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008].
Disorder MIM:	138243

mRNA and Protein(s)

mRNA	Protein	Name
NM_000831.3	NP_000822.2	glutamate receptor ionotropic, kainate 3 precursor
NM_000831.4	NP_000822.2	glutamate receptor ionotropic, kainate 3 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GRIK3	NP_001192932.1
Danio rerio (zebrafish)	LOC100334689	XP_002664816.3
	LOC713545	XP_001111351.1
Canis lupus familiaris (dog)	LOC608269	XP_850331.3
Rattus norvegicus (Norway rat)	Grik3	NP_001106187.1
Homo sapiens (human)	GRIK3	NP_000822.2
Pan troglodytes (chimpanzee)	GRIK3	XP_524666.2
Mus musculus (house mouse)	Grik3	NP_001074566.1
Gallus gallus (chicken)	GRIK3	XP_417766.2
Xenopus tropicalis (tropical clawed frog)	LOC100498426	XP_002938663.2

Gene Ontology
Bibliography

Related articles in PubMed

GRIK3: A novel oncogenic protein related to tumor TNM stage, lymph node metastasis, and poor prognosis of GC.
Gong B, Li Y, Cheng Z, Wang P, Luo L, Huang H, Duan S, Liu F
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(6)1010428317704364(2017 Jun)

Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN
Journal of clinical periodontology44(4)394-402(2017 Apr)

1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay.
Takenouchi T, Hashida N, Torii C, Kosaki R, Takahashi T, Kosaki K
American journal of medical genetics. Part A164A(2)456-60(2014 Feb)

A comprehensive family-based replication study of schizophrenia genes.
Aberg KA, Liu Y, Buksz?r J, McClay JL, Khachane AN, Andreassen OA, Blackwood D, Corvin A, Djurovic S, Gurling H, Ophoff R, Pato CN, Pato MT, Riley B, Webb T, Kendler K, O'Donovan M, Craddock N, Kirov G, Owen M, Rujescu D, St Clair D, Werge T, Hultman CM, Delisi LE, Sullivan P, van den Oord EJ
JAMA psychiatry70(6)573-81(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

additional experiment showed that the lymph node metastasis tissues had higher GRIK3 expression than their matched primary gastric cancer (GC) tissues. These findings suggested that elevated GRIK3 expression could serve as an independent prognostic biomarker and a novel potential treatment target for patients with GC.
Title: GRIK3: A novel oncogenic protein related to tumor TNM stage, lymph node metastasis, and poor prognosis of GC.

GRIK3 expression is significantly downregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.

1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay.
Title: 1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay.

Analyses revealed that polymorphism Ser310Ala of GRIK3 gene is not associated with alcohol dependence or any of its subgroups.
Title: Family-based and case-control study of glutamate receptor GRIK3 Ser310Ala polymorphism in alcohol dependence.

Our results suggest that the analysed polymorphisms ofANKK1 and ADH4 can play an important part in the pathogenesis of alcohol abuse
Title: [Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome].

The following GRIK3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GRIK3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18797	NM_000831.4 Latest version!	Homo sapiens glutamate ionotropic receptor kainate type subunit 3 (GRIK3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
View Old Accession Versions >>
OHu18797	NM_000831.3	Homo sapiens glutamate ionotropic receptor kainate type subunit 3 (GRIK3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GRIK3 ( NM_000831.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000822.2 Homo sapiens glutamate ionotropic receptor kainate type subunit 3 (GRIK3), mRNA.

Price & Availability↑

CloneID	OHu18797
Clone ID Related Accession (Same CDS sequence)	NM_000831.3 , NM_000831.4
Accession Version	NM_000831.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2760bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	glutamate receptor ionotropic, kainate 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355386.9, DR003075.1, AJ249210.1, U16127.1, AW898512.1, AC117945.2, BG818719.1, DT217951.1, BQ446793.1 and BG057125.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000831.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.159793.1, U16127.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145544 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373091.8/ ENSP00000362183.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCGCTC CCTGGCGGCG CCTCCGGAGT CTGGTTTGGG AATACTGGGC CGGGCTCCTC 
GTGTGCGCCT TCTGGATCCC GGACTCGCGC GGGATGCCCC ACGTCATCCG GATCGGAGGA 
ATCTTCGAGT ATGCGGACGG CCCCAACGCC CAGGTCATGA ATGCCGAGGA GCATGCCTTT 
CGATTTTCTG CCAACATCAT CAACAGGAAC AGGACTCTGC TGCCCAACAC AACCTTGACC 
TATGACATAC AGAGGATTCA CTTCCATGAC AGCTTCGAGG CGACCAAAAA GGCCTGTGAC 
CAGCTGGCAC TGGGCGTGGT GGCGATCTTC GGCCCATCAC AGGGCTCCTG CACCAATGCC 
GTCCAGTCCA TCTGCAATGC CCTGGAGGTG CCCCACATCC AGCTGCGTTG GAAGCACCAC 
CCGCTGGACA ACAAGGACAC CTTCTACGTG AACCTCTACC CCGACTACGC CTCGCTCAGC 
CATGCCATCC TCGACCTGGT CCAGTACCTC AAGTGGCGGT CAGCCACCGT GGTCTATGAC 
GACAGTACAG GGCTCATCCG ACTGCAGGAG CTCATCATGG CCCCATCAAG ATACAACATC 
CGCCTGAAGA TCCGTCAGCT CCCCATCGAC TCTGACGACT CGCGCCCCTT GCTCAAGGAG 
ATGAAGCGAG GCCGGGAATT CCGCATTATC TTCGACTGCA GCCACACTAT GGCGGCCCAG 
ATCCTCAAGC AGGCCATGGC CATGGGCATG ATGACTGAGT ACTACCACTT CATCTTCACC 
ACTCTGGATC TCTACGCTTT AGACCTGGAG CCCTACCGCT ACTCAGGCGT GAACCTGACA 
GGATTCCGGA TTCTCAATGT GGACAACCCA CACGTCTCGG CCATTGTGGA GAAGTGGTCC 
ATGGAGCGGC TGCAGGCAGC TCCCCGGTCC GAGTCTGGCC TGCTGGATGG AGTGATGATG 
ACTGATGCAG CCTTACTGTA CGACGCCGTC CATATCGTGT CCGTGTGCTA CCAGCGGGCA 
CCACAGATGA CCGTGAACTC CCTGCAGTGC CATCGGCACA AGGCCTGGCG CTTTGGCGGC 
CGCTTCATGA ACTTCATCAA GGAGGCTCAA TGGGAAGGAT TAACTGGACG AATTGTTTTC 
AACAAAACTA GTGGCTTGCG GACGGATTTT GATCTGGACA TCATCAGCCT GAAAGAGGAT 
GGCCTGGAGA AGGTTGGGGT GTGGAGTCCT GCCGACGGGC TCAACATCAC TGAGGTTGCC 
AAAGGCCGAG GCCCTAATGT CACCGACTCT CTGACAAACA GATCACTCAT TGTCACCACA 
GTGCTGGAGG AGCCCTTCGT CATGTTTCGG AAATCAGACA GGACGCTATA CGGGAATGAC 
CGGTTCGAGG GCTACTGCAT CGACCTGCTA AAGGAGCTGG CCCACATCCT TGGTTTCTCC 
TATGAGATCC GGCTGGTGGA GGACGGCAAG TACGGGGCAC AGGATGACAA GGGCCAGTGG 
AACGGCATGG TCAAGGAGCT CATCGACCAC AAGGCAGATC TGGCCGTGGC CCCCCTGACC 
ATCACCCATG TTCGAGAGAA GGCCATCGAC TTCTCCAAGC CCTTCATGAC ACTTGGTGTG 
AGCATCCTGT ATCGAAAGCC CAATGGCACC AACCCCAGCG TCTTCTCCTT CCTCAATCCC 
CTGTCCCCAG ACATCTGGAT GTATGTTCTC CTCGCCTACC TGGGGGTCAG CTGTGTCCTC 
TTCGTCATCG CCAGGTTCAG CCCTTATGAG TGGTACGATG CTCACCCCTG CAACCCTGGC 
TCCGAGGTGG TGGAAAATAA CTTCACTCTG CTTAACAGCT TCTGGTTTGG AATGGGATCC 
CTGATGCAGC AAGGGTCTGA GCTGATGCCC AAAGCCCTGT CCACACGCAT CATTGGTGGC 
ATCTGGTGGT TCTTCACGCT CATCATCATC TCTTCCTACA CGGCCAACCT GGCTGCCTTT 
CTGACCGTGG AGCGCATGGA ATCACCCATT GACTCTGCTG ATGACCTGGC CAAGCAAACC 
AAAATCGAGT ATGGGGCTGT CAAGGATGGG GCCACCATGA CCTTCTTCAA GAAATCCAAG 
ATCTCCACCT TCGAGAAGAT GTGGGCCTTC ATGAGCAGCA AGCCATCGGC GCTGGTGAAG 
AACAACGAGG AGGGCATCCA GAGGGCCCTG ACGGCCGACT ACGCGCTGCT CATGGAGTCC 
ACCACCATCG AGTACGTCAC GCAGAGGAAC TGCAACCTCA CCCAGATCGG GGGCCTCATT 
GACTCCAAGG GCTACGGCAT CGGCACGCCC ATGGGCTCCC CATACCGGGA CAAGATCACC 
ATCGCCATCC TGCAGCTTCA GGAGGAGGAC AAGCTGCATA TCATGAAGGA GAAGTGGTGG 
CGGGGCAGCG GGTGTCCTGA GGAGGAAAAC AAAGAGGCCA GTGCCCTGGG GATCCAGAAG 
ATCGGGGGCA TCTTCATTGT CCTGGCCGCC GGGCTGGTCC TCTCTGTGCT GGTGGCCGTG 
GGCGAGTTTG TGTACAAGCT CCGCAAAACA GCAGAGAGAG AGCAGCGTTC CTTCTGCAGC 
ACCGTGGCCG ATGAGATCCG TTTCTCCCTT ACCTGCCAGC GTCGAGTCAA GCACAAGCCT 
CAGCCTCCCA TGATGGTCAA GACTGACGCC GTCATCAACA TGCACACATT CAATGACCGC 
CGGCTTCCCG GCAAGGACAG CATGGCCTGC AGCACATCCT TAGCCCCTGT GTTCCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000822.2
CDS	408..3167
Translation	MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMACSTSLAPVFP

Target ORF information:

RefSeq Version	NM_000831.4
Organism	Homo sapiens(human)
Definition	Homo sapiens glutamate ionotropic receptor kainate type subunit 3 (GRIK3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000831.4

ORF Insert Sequence:

ATGACCGCTC CCTGGCGGCG CCTCCGGAGT CTGGTTTGGG AATACTGGGC CGGGCTCCTC 
GTGTGCGCCT TCTGGATCCC GGACTCGCGC GGGATGCCCC ACGTCATCCG GATCGGAGGA 
ATCTTCGAGT ATGCGGACGG CCCCAACGCC CAGGTCATGA ATGCCGAGGA GCATGCCTTT 
CGATTTTCTG CCAACATCAT CAACAGGAAC AGGACTCTGC TGCCCAACAC AACCTTGACC 
TATGACATAC AGAGGATTCA CTTCCATGAC AGCTTCGAGG CGACCAAAAA GGCCTGTGAC 
CAGCTGGCAC TGGGCGTGGT GGCGATCTTC GGCCCATCAC AGGGCTCCTG CACCAATGCC 
GTCCAGTCCA TCTGCAATGC CCTGGAGGTG CCCCACATCC AGCTGCGTTG GAAGCACCAC 
CCGCTGGACA ACAAGGACAC CTTCTACGTG AACCTCTACC CCGACTACGC CTCGCTCAGC 
CATGCCATCC TCGACCTGGT CCAGTACCTC AAGTGGCGGT CAGCCACCGT GGTCTATGAC 
GACAGTACAG GGCTCATCCG ACTGCAGGAG CTCATCATGG CCCCATCAAG ATACAACATC 
CGCCTGAAGA TCCGTCAGCT CCCCATCGAC TCTGACGACT CGCGCCCCTT GCTCAAGGAG 
ATGAAGCGAG GCCGGGAATT CCGCATTATC TTCGACTGCA GCCACACTAT GGCGGCCCAG 
ATCCTCAAGC AGGCCATGGC CATGGGCATG ATGACTGAGT ACTACCACTT CATCTTCACC 
ACTCTGGATC TCTACGCTTT AGACCTGGAG CCCTACCGCT ACTCAGGCGT GAACCTGACA 
GGATTCCGGA TTCTCAATGT GGACAACCCA CACGTCTCGG CCATTGTGGA GAAGTGGTCC 
ATGGAGCGGC TGCAGGCAGC TCCCCGGTCC GAGTCTGGCC TGCTGGATGG AGTGATGATG 
ACTGATGCAG CCTTACTGTA CGACGCCGTC CATATCGTGT CCGTGTGCTA CCAGCGGGCA 
CCACAGATGA CCGTGAACTC CCTGCAGTGC CATCGGCACA AGGCCTGGCG CTTTGGCGGC 
CGCTTCATGA ACTTCATCAA GGAGGCTCAA TGGGAAGGAT TAACTGGACG AATTGTTTTC 
AACAAAACTA GTGGCTTGCG GACGGATTTT GATCTGGACA TCATCAGCCT GAAAGAGGAT 
GGCCTGGAGA AGGTTGGGGT GTGGAGTCCT GCCGACGGGC TCAACATCAC TGAGGTTGCC 
AAAGGCCGAG GCCCTAATGT CACCGACTCT CTGACAAACA GATCACTCAT TGTCACCACA 
GTGCTGGAGG AGCCCTTCGT CATGTTTCGG AAATCAGACA GGACGCTATA CGGGAATGAC 
CGGTTCGAGG GCTACTGCAT CGACCTGCTA AAGGAGCTGG CCCACATCCT TGGTTTCTCC 
TATGAGATCC GGCTGGTGGA GGACGGCAAG TACGGGGCAC AGGATGACAA GGGCCAGTGG 
AACGGCATGG TCAAGGAGCT CATCGACCAC AAGGCAGATC TGGCCGTGGC CCCCCTGACC 
ATCACCCATG TTCGAGAGAA GGCCATCGAC TTCTCCAAGC CCTTCATGAC ACTTGGTGTG 
AGCATCCTGT ATCGAAAGCC CAATGGCACC AACCCCAGCG TCTTCTCCTT CCTCAATCCC 
CTGTCCCCAG ACATCTGGAT GTATGTTCTC CTCGCCTACC TGGGGGTCAG CTGTGTCCTC 
TTCGTCATCG CCAGGTTCAG CCCTTATGAG TGGTACGATG CTCACCCCTG CAACCCTGGC 
TCCGAGGTGG TGGAAAATAA CTTCACTCTG CTTAACAGCT TCTGGTTTGG AATGGGATCC 
CTGATGCAGC AAGGGTCTGA GCTGATGCCC AAAGCCCTGT CCACACGCAT CATTGGTGGC 
ATCTGGTGGT TCTTCACGCT CATCATCATC TCTTCCTACA CGGCCAACCT GGCTGCCTTT 
CTGACCGTGG AGCGCATGGA ATCACCCATT GACTCTGCTG ATGACCTGGC CAAGCAAACC 
AAAATCGAGT ATGGGGCTGT CAAGGATGGG GCCACCATGA CCTTCTTCAA GAAATCCAAG 
ATCTCCACCT TCGAGAAGAT GTGGGCCTTC ATGAGCAGCA AGCCATCGGC GCTGGTGAAG 
AACAACGAGG AGGGCATCCA GAGGGCCCTG ACGGCCGACT ACGCGCTGCT CATGGAGTCC 
ACCACCATCG AGTACGTCAC GCAGAGGAAC TGCAACCTCA CCCAGATCGG GGGCCTCATT 
GACTCCAAGG GCTACGGCAT CGGCACGCCC ATGGGCTCCC CATACCGGGA CAAGATCACC 
ATCGCCATCC TGCAGCTTCA GGAGGAGGAC AAGCTGCATA TCATGAAGGA GAAGTGGTGG 
CGGGGCAGCG GGTGTCCTGA GGAGGAAAAC AAAGAGGCCA GTGCCCTGGG GATCCAGAAG 
ATCGGGGGCA TCTTCATTGT CCTGGCCGCC GGGCTGGTCC TCTCTGTGCT GGTGGCCGTG 
GGCGAGTTTG TGTACAAGCT CCGCAAAACA GCAGAGAGAG AGCAGCGTTC CTTCTGCAGC 
ACCGTGGCCG ATGAGATCCG TTTCTCCCTT ACCTGCCAGC GTCGAGTCAA GCACAAGCCT 
CAGCCTCCCA TGATGGTCAA GACTGACGCC GTCATCAACA TGCACACATT CAATGACCGC 
CGGCTTCCCG GCAAGGACAG CATGGCCTGC AGCACATCCT TAGCCCCTGT GTTCCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GRIK3 ( NM_000831.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000822.2 Homo sapiens glutamate ionotropic receptor kainate type subunit 3 (GRIK3), mRNA.

Price & Availability↑

CloneID	OHu18797
Clone ID Related Accession (Same CDS sequence)	NM_000831.3 , NM_000831.4
Accession Version	NM_000831.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2760bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	glutamate receptor ionotropic, kainate 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DR003075.1, AJ249210.1, U16127.1, AW898512.1, AC117945.2, BG818719.1, DT217951.1, BQ446793.1 and BG057125.1. This sequence is a reference standard in the RefSeqGene project. On Dec 20, 2007 this sequence version replaced NM_000831.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.159793.1, U16127.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145544 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCGCTC CCTGGCGGCG CCTCCGGAGT CTGGTTTGGG AATACTGGGC CGGGCTCCTC 
GTGTGCGCCT TCTGGATCCC GGACTCGCGC GGGATGCCCC ACGTCATCCG GATCGGAGGA 
ATCTTCGAGT ATGCGGACGG CCCCAACGCC CAGGTCATGA ATGCCGAGGA GCATGCCTTT 
CGATTTTCTG CCAACATCAT CAACAGGAAC AGGACTCTGC TGCCCAACAC AACCTTGACC 
TATGACATAC AGAGGATTCA CTTCCATGAC AGCTTCGAGG CGACCAAAAA GGCCTGTGAC 
CAGCTGGCAC TGGGCGTGGT GGCGATCTTC GGCCCATCAC AGGGCTCCTG CACCAATGCC 
GTCCAGTCCA TCTGCAATGC CCTGGAGGTG CCCCACATCC AGCTGCGTTG GAAGCACCAC 
CCGCTGGACA ACAAGGACAC CTTCTACGTG AACCTCTACC CCGACTACGC CTCGCTCAGC 
CATGCCATCC TCGACCTGGT CCAGTACCTC AAGTGGCGGT CAGCCACCGT GGTCTATGAC 
GACAGTACAG GGCTCATCCG ACTGCAGGAG CTCATCATGG CCCCATCAAG ATACAACATC 
CGCCTGAAGA TCCGTCAGCT CCCCATCGAC TCTGACGACT CGCGCCCCTT GCTCAAGGAG 
ATGAAGCGAG GCCGGGAATT CCGCATTATC TTCGACTGCA GCCACACTAT GGCGGCCCAG 
ATCCTCAAGC AGGCCATGGC CATGGGCATG ATGACTGAGT ACTACCACTT CATCTTCACC 
ACTCTGGATC TCTACGCTTT AGACCTGGAG CCCTACCGCT ACTCAGGCGT GAACCTGACA 
GGATTCCGGA TTCTCAATGT GGACAACCCA CACGTCTCGG CCATTGTGGA GAAGTGGTCC 
ATGGAGCGGC TGCAGGCAGC TCCCCGGTCC GAGTCTGGCC TGCTGGATGG AGTGATGATG 
ACTGATGCAG CCTTACTGTA CGACGCCGTC CATATCGTGT CCGTGTGCTA CCAGCGGGCA 
CCACAGATGA CCGTGAACTC CCTGCAGTGC CATCGGCACA AGGCCTGGCG CTTTGGCGGC 
CGCTTCATGA ACTTCATCAA GGAGGCTCAA TGGGAAGGAT TAACTGGACG AATTGTTTTC 
AACAAAACTA GTGGCTTGCG GACGGATTTT GATCTGGACA TCATCAGCCT GAAAGAGGAT 
GGCCTGGAGA AGGTTGGGGT GTGGAGTCCT GCCGACGGGC TCAACATCAC TGAGGTTGCC 
AAAGGCCGAG GCCCTAATGT CACCGACTCT CTGACAAACA GATCACTCAT TGTCACCACA 
GTGCTGGAGG AGCCCTTCGT CATGTTTCGG AAATCAGACA GGACGCTATA CGGGAATGAC 
CGGTTCGAGG GCTACTGCAT CGACCTGCTA AAGGAGCTGG CCCACATCCT TGGTTTCTCC 
TATGAGATCC GGCTGGTGGA GGACGGCAAG TACGGGGCAC AGGATGACAA GGGCCAGTGG 
AACGGCATGG TCAAGGAGCT CATCGACCAC AAGGCAGATC TGGCCGTGGC CCCCCTGACC 
ATCACCCATG TTCGAGAGAA GGCCATCGAC TTCTCCAAGC CCTTCATGAC ACTTGGTGTG 
AGCATCCTGT ATCGAAAGCC CAATGGCACC AACCCCAGCG TCTTCTCCTT CCTCAATCCC 
CTGTCCCCAG ACATCTGGAT GTATGTTCTC CTCGCCTACC TGGGGGTCAG CTGTGTCCTC 
TTCGTCATCG CCAGGTTCAG CCCTTATGAG TGGTACGATG CTCACCCCTG CAACCCTGGC 
TCCGAGGTGG TGGAAAATAA CTTCACTCTG CTTAACAGCT TCTGGTTTGG AATGGGATCC 
CTGATGCAGC AAGGGTCTGA GCTGATGCCC AAAGCCCTGT CCACACGCAT CATTGGTGGC 
ATCTGGTGGT TCTTCACGCT CATCATCATC TCTTCCTACA CGGCCAACCT GGCTGCCTTT 
CTGACCGTGG AGCGCATGGA ATCACCCATT GACTCTGCTG ATGACCTGGC CAAGCAAACC 
AAAATCGAGT ATGGGGCTGT CAAGGATGGG GCCACCATGA CCTTCTTCAA GAAATCCAAG 
ATCTCCACCT TCGAGAAGAT GTGGGCCTTC ATGAGCAGCA AGCCATCGGC GCTGGTGAAG 
AACAACGAGG AGGGCATCCA GAGGGCCCTG ACGGCCGACT ACGCGCTGCT CATGGAGTCC 
ACCACCATCG AGTACGTCAC GCAGAGGAAC TGCAACCTCA CCCAGATCGG GGGCCTCATT 
GACTCCAAGG GCTACGGCAT CGGCACGCCC ATGGGCTCCC CATACCGGGA CAAGATCACC 
ATCGCCATCC TGCAGCTTCA GGAGGAGGAC AAGCTGCATA TCATGAAGGA GAAGTGGTGG 
CGGGGCAGCG GGTGTCCTGA GGAGGAAAAC AAAGAGGCCA GTGCCCTGGG GATCCAGAAG 
ATCGGGGGCA TCTTCATTGT CCTGGCCGCC GGGCTGGTCC TCTCTGTGCT GGTGGCCGTG 
GGCGAGTTTG TGTACAAGCT CCGCAAAACA GCAGAGAGAG AGCAGCGTTC CTTCTGCAGC 
ACCGTGGCCG ATGAGATCCG TTTCTCCCTT ACCTGCCAGC GTCGAGTCAA GCACAAGCCT 
CAGCCTCCCA TGATGGTCAA GACTGACGCC GTCATCAACA TGCACACATT CAATGACCGC 
CGGCTTCCCG GCAAGGACAG CATGGCCTGC AGCACATCCT TAGCCCCTGT GTTCCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000822.2
CDS	136..2895
Translation	MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMACSTSLAPVFP

Target ORF information:

RefSeq Version	NM_000831.3
Organism	Homo sapiens(human)
Definition	Homo sapiens glutamate ionotropic receptor kainate type subunit 3 (GRIK3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000831.3

ORF Insert Sequence:

ATGACCGCTC CCTGGCGGCG CCTCCGGAGT CTGGTTTGGG AATACTGGGC CGGGCTCCTC 
GTGTGCGCCT TCTGGATCCC GGACTCGCGC GGGATGCCCC ACGTCATCCG GATCGGAGGA 
ATCTTCGAGT ATGCGGACGG CCCCAACGCC CAGGTCATGA ATGCCGAGGA GCATGCCTTT 
CGATTTTCTG CCAACATCAT CAACAGGAAC AGGACTCTGC TGCCCAACAC AACCTTGACC 
TATGACATAC AGAGGATTCA CTTCCATGAC AGCTTCGAGG CGACCAAAAA GGCCTGTGAC 
CAGCTGGCAC TGGGCGTGGT GGCGATCTTC GGCCCATCAC AGGGCTCCTG CACCAATGCC 
GTCCAGTCCA TCTGCAATGC CCTGGAGGTG CCCCACATCC AGCTGCGTTG GAAGCACCAC 
CCGCTGGACA ACAAGGACAC CTTCTACGTG AACCTCTACC CCGACTACGC CTCGCTCAGC 
CATGCCATCC TCGACCTGGT CCAGTACCTC AAGTGGCGGT CAGCCACCGT GGTCTATGAC 
GACAGTACAG GGCTCATCCG ACTGCAGGAG CTCATCATGG CCCCATCAAG ATACAACATC 
CGCCTGAAGA TCCGTCAGCT CCCCATCGAC TCTGACGACT CGCGCCCCTT GCTCAAGGAG 
ATGAAGCGAG GCCGGGAATT CCGCATTATC TTCGACTGCA GCCACACTAT GGCGGCCCAG 
ATCCTCAAGC AGGCCATGGC CATGGGCATG ATGACTGAGT ACTACCACTT CATCTTCACC 
ACTCTGGATC TCTACGCTTT AGACCTGGAG CCCTACCGCT ACTCAGGCGT GAACCTGACA 
GGATTCCGGA TTCTCAATGT GGACAACCCA CACGTCTCGG CCATTGTGGA GAAGTGGTCC 
ATGGAGCGGC TGCAGGCAGC TCCCCGGTCC GAGTCTGGCC TGCTGGATGG AGTGATGATG 
ACTGATGCAG CCTTACTGTA CGACGCCGTC CATATCGTGT CCGTGTGCTA CCAGCGGGCA 
CCACAGATGA CCGTGAACTC CCTGCAGTGC CATCGGCACA AGGCCTGGCG CTTTGGCGGC 
CGCTTCATGA ACTTCATCAA GGAGGCTCAA TGGGAAGGAT TAACTGGACG AATTGTTTTC 
AACAAAACTA GTGGCTTGCG GACGGATTTT GATCTGGACA TCATCAGCCT GAAAGAGGAT 
GGCCTGGAGA AGGTTGGGGT GTGGAGTCCT GCCGACGGGC TCAACATCAC TGAGGTTGCC 
AAAGGCCGAG GCCCTAATGT CACCGACTCT CTGACAAACA GATCACTCAT TGTCACCACA 
GTGCTGGAGG AGCCCTTCGT CATGTTTCGG AAATCAGACA GGACGCTATA CGGGAATGAC 
CGGTTCGAGG GCTACTGCAT CGACCTGCTA AAGGAGCTGG CCCACATCCT TGGTTTCTCC 
TATGAGATCC GGCTGGTGGA GGACGGCAAG TACGGGGCAC AGGATGACAA GGGCCAGTGG 
AACGGCATGG TCAAGGAGCT CATCGACCAC AAGGCAGATC TGGCCGTGGC CCCCCTGACC 
ATCACCCATG TTCGAGAGAA GGCCATCGAC TTCTCCAAGC CCTTCATGAC ACTTGGTGTG 
AGCATCCTGT ATCGAAAGCC CAATGGCACC AACCCCAGCG TCTTCTCCTT CCTCAATCCC 
CTGTCCCCAG ACATCTGGAT GTATGTTCTC CTCGCCTACC TGGGGGTCAG CTGTGTCCTC 
TTCGTCATCG CCAGGTTCAG CCCTTATGAG TGGTACGATG CTCACCCCTG CAACCCTGGC 
TCCGAGGTGG TGGAAAATAA CTTCACTCTG CTTAACAGCT TCTGGTTTGG AATGGGATCC 
CTGATGCAGC AAGGGTCTGA GCTGATGCCC AAAGCCCTGT CCACACGCAT CATTGGTGGC 
ATCTGGTGGT TCTTCACGCT CATCATCATC TCTTCCTACA CGGCCAACCT GGCTGCCTTT 
CTGACCGTGG AGCGCATGGA ATCACCCATT GACTCTGCTG ATGACCTGGC CAAGCAAACC 
AAAATCGAGT ATGGGGCTGT CAAGGATGGG GCCACCATGA CCTTCTTCAA GAAATCCAAG 
ATCTCCACCT TCGAGAAGAT GTGGGCCTTC ATGAGCAGCA AGCCATCGGC GCTGGTGAAG 
AACAACGAGG AGGGCATCCA GAGGGCCCTG ACGGCCGACT ACGCGCTGCT CATGGAGTCC 
ACCACCATCG AGTACGTCAC GCAGAGGAAC TGCAACCTCA CCCAGATCGG GGGCCTCATT 
GACTCCAAGG GCTACGGCAT CGGCACGCCC ATGGGCTCCC CATACCGGGA CAAGATCACC 
ATCGCCATCC TGCAGCTTCA GGAGGAGGAC AAGCTGCATA TCATGAAGGA GAAGTGGTGG 
CGGGGCAGCG GGTGTCCTGA GGAGGAAAAC AAAGAGGCCA GTGCCCTGGG GATCCAGAAG 
ATCGGGGGCA TCTTCATTGT CCTGGCCGCC GGGCTGGTCC TCTCTGTGCT GGTGGCCGTG 
GGCGAGTTTG TGTACAAGCT CCGCAAAACA GCAGAGAGAG AGCAGCGTTC CTTCTGCAGC 
ACCGTGGCCG ATGAGATCCG TTTCTCCCTT ACCTGCCAGC GTCGAGTCAA GCACAAGCCT 
CAGCCTCCCA TGATGGTCAA GACTGACGCC GTCATCAACA TGCACACATT CAATGACCGC 
CGGCTTCCCG GCAAGGACAG CATGGCCTGC AGCACATCCT TAGCCCCTGT GTTCCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GRIK3: A novel oncogenic protein related to tumor TNM stage, lymph node metastasis, and poor prognosis of GC.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(6)1010428317704364(2017 Jun)
Gong B,Li Y,Cheng Z,Wang P,Luo L,Huang H,Duan S,Liu F

Human gingiva transcriptome during wound healing.
Journal of clinical periodontology44(4)394-402(2017 Apr)
Wang Y,Tatakis DN

1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay.
American journal of medical genetics. Part A164A(2)456-60(2014 Feb)
Takenouchi T,Hashida N,Torii C,Kosaki R,Takahashi T,Kosaki K

A comprehensive family-based replication study of schizophrenia genes.
JAMA psychiatry70(6)573-81(2013 Jun)
Aberg KA,Liu Y,Buksz?r J,McClay JL,Khachane AN,Andreassen OA,Blackwood D,Corvin A,Djurovic S,Gurling H,Ophoff R,Pato CN,Pato MT,Riley B,Webb T,Kendler K,O'Donovan M,Craddock N,Kirov G,Owen M,Rujescu D,St Clair D,Werge T,Hultman CM,Delisi LE,Sullivan P,van den Oord EJ

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GRIK3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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