SH3PXD2B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SH3PXD2B
Entrez Gene ID	285590
Full Name	SH3 and PX domains 2B
Synonyms	FAD49,FTHS,HOFI,KIAA1295,TKS4,TSK4
General protein information	Preferred Names SH3 and PX domains 2B Names SH3 and PX domain-containing protein 2B adapter protein HOFI adaptor protein HOFI factor for adipocyte differentiation 49 tyrosine kinase substrate with four SH3 domains
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q35.1
Summary	This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome (FTHS), and also Borrone Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Disorder MIM:	613293
Disorder Html:	Frank-ter Haar syndrome, 249420 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001308175.1	NP_001295104.1	SH3 and PX domain-containing protein 2B isoform b
NM_001017995.3	NP_001017995.1	SH3 and PX domain-containing protein 2B isoform a
XM_017009351.1	XP_016864840.1	SH3 and PX domain-containing protein 2B isoform X1
NM_001017995.2	NP_001017995.1	SH3 and PX domain-containing protein 2B isoform a

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SH3PXD2B	XP_527118.2
Bos taurus (cattle)	SH3PXD2B	XP_002696316.2
Gallus gallus (chicken)	SH3PXD2B	XP_425197.3
Homo sapiens (human)	SH3PXD2B	NP_001017995.1
Canis lupus familiaris (dog)	SH3PXD2B	XP_546237.5
Rattus norvegicus (Norway rat)	Sh3pxd2b	XP_006246168.1
Danio rerio (zebrafish)	sh3pxd2b	XP_005170345.1
Mus musculus (house mouse)	Sh3pxd2b	NP_796338.2
	SH3PXD2B	XP_001095586.1
Xenopus tropicalis (tropical clawed frog)	sh3pxd2b	NP_001016567.2

Gene Ontology
Bibliography

Related articles in PubMed

Ophthalmic findings in Frank-ter Haar syndrome: report of a sibling pair.
Chang TC, Bauer M, Puerta HS, Greenberg MB, Cavuoto KM
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus21(6)514-516(2017 Dec)

The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.
Iizuka S, Abdullah C, Buschman MD, Diaz B, Courtneidge SA
Oncotarget7(48)78473-78486(2016 Nov)

Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes.
?d?m C, Fekete A, B?gel G, N?meth Z, T?k?si N, Ov?di J, Liliom K, Pesti S, Geiszt M, Buday L
Cell communication and signaling : CCS1333(2015 Jul)

Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults.
Scannell Bryan M, Argos M, Pierce B, Tong L, Rakibuz-Zaman M, Ahmed A, Rahman M, Islam T, Yunus M, Parvez F, Roy S, Jasmine F, Baron JA, Kibriya MG, Ahsan H
PloS one9(8)e105062(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Misfolded Frank-ter Haar syndrome protein Tks4(R43W) is transported via the microtubule system to the aggresomes.
Title: Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes.

a new function for Tks4 in the regulation of growth factor-dependent cell migration.
Title: Frank-ter Haar syndrome protein Tks4 regulates epidermal growth factor-dependent cell migration.

Tks4 and Tks5 directly bind to NoxA1. The integrity of the N-terminal PRR of NoxA1 is essential for this direct interaction with the Tks proteins.
Title: Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation.

SH3PXD2B is a scaffold protein that plays a key role in regulating the actin cytoskeleton via Src and cortactin.
Title: The homolog of the five SH3-domain protein (HOFI/SH3PXD2B) regulates lamellipodia formation and cell spreading.

The Nox1-dependent generation of reactive oxygen species is dependent on Src phosphorylation of NoxA1 and Tks4. Blockage of phosphorylation of NoxA1 and Tks4 decreases Nox1-dependent ROS generation and blocks SrcYF-induced invadopodia formation.
Title: c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells.

The following SH3PXD2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SH3PXD2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu39991	NM_001308175.1 Latest version!	Homo sapiens SH3 and PX domains 2B (SH3PXD2B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu19671	NM_001017995.3 Latest version!	Homo sapiens SH3 and PX domains 2B (SH3PXD2B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$643.30 $919.00
OHu95828	XM_017009351.1 Latest version!	Homo sapiens SH3 and PX domains 2B (SH3PXD2B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
View Old Accession Versions >>
OHu19671	NM_001017995.2	Homo sapiens SH3 and PX domains 2B (SH3PXD2B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$643.30 $919.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SH3PXD2B ( NM_001308175.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001295104.1 Homo sapiens SH3 and PX domains 2B (SH3PXD2B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu39991
Clone ID Related Accession (Same CDS sequence)	NM_001308175.1
Accession Version	NM_001308175.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1293bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-08
Organism	Homo sapiens(human)
Product	SH3 and PX domain-containing protein 2B isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK128871.1 and BC038561.1. On Apr 28, 2015 this sequence version replaced XM_005265888.1. Transcript Variant: This variant (2) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC038561.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGCCGC GGCGCAGCAT CGTGGAGGTG AAGGTGCTAG ACGTGCAGAA GCGGCGGGTG 
CCCAACAAGC ATTATGTCTA CATCATCCGG GTCACGTGGT CCAGCGGCTC CACCGAGGCC 
ATTTACCGGC GCTACAGCAA GTTTTTTGAC CTCCAGATGC AGATGTTGGA CAAATTTCCC 
ATGGAAGGAG GACAGAAGGA CCCCAAGCAG CGGATCATCC CCTTTCTGCC AGGTAAGATT 
CTCTTCAGAC GAAGCCACAT CCGGGACGTG GCTGTCAAAC GCCTGATACC AATTGATGAA 
TACTGTAAGG CCCTCATCCA GCTGCCCCCC TACATCTCTC AGTGTGATGA GGTGCTGCAG 
TTCTTTGAGA CAAGACCTGA GGACCTGAAT CCCCCCAAAG AGGAGCACAT TGGGAAAAAG 
AAATCTGGGG GTGACCAAAC CTCAGTGGAC CCCATGGTCC TGGAGCAGTA TGTGGTGGTA 
GCCAACTACC AGAAGCAGGA GAGTTCGGAG ATCAGCCTCA GCGTGGGGCA GGTGGTGGAC 
ATCATCGAGA AGAATGAGTC AGGTTGGTGG TTCGTCAGCA CTGCCGAGGA GCAAGGCTGG 
GTCCCTGCAA CGTGCCTCGA AGGCCAGGAT GGGGTGCAGG ATGAGTTTTC TCTGCAGCCT 
GAAGAAGAGG AGAAGTACAC AGTCATCTAC CCGTACACAG CTCGGGACCA GGATGAAATG 
AACCTGGAGA GAGGGGCTGT GGTGGAGGTC ATCCAGAAAA ACCTGGAAGG CTGGTGGAAG 
ATCAGGTACC AGGGCAAAGA AGGCTGGGCC CCCGCCTCCT ACCTAAAGAA GAACAGTGGG 
GAGCCCTTGC CCCCGAAGCC AGGCCCTGGC TCACCCTCCC ACCCGGGTGC CCTTGACTTG 
GATGGTGTTT CCCGGCAGCA GAACGCGGTG GGCAGGGAGA AGGAGCTGCT CAGCAGCCAG 
AGGGACGGGC GGTTTGAAGG CCGCCCGGTG CCCGACGGTG ACGCCAAGCA GAGATCACCA 
AAGATGAGGC AGAGACCCCC TCCTCGCCGG GACATGACCA TTCCTCGAGG CCTCAACCTG 
CCGAAGCCGC CCATCCCGCC CCAAGTGGAG GAAGAGTATT ACACCATCGC CGAATTCCAG 
ACAACCATCC CAGACGGCAT CAGCTTCCAG GCAGGCCTGA AGGTCGAGGA TCATAAGAAT 
GTTCACTTGG AGAGCCCTGT GGAAGTCCCT CTTAGAAGAA TCAAGATGCG GACAGCACTT 
GGGAAGCACG TGGCAGCTTC CATGGAGATG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001295104.1
CDS	172..1464
Translation	MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEDHKNVHLESPVEVPLRRIKMRTALGKHVAASMEM

Target ORF information:

RefSeq Version	NM_001308175.1
Organism	Homo sapiens(human)
Definition	Homo sapiens SH3 and PX domains 2B (SH3PXD2B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308175.1

ORF Insert Sequence:

ATGCCGCCGC GGCGCAGCAT CGTGGAGGTG AAGGTGCTAG ACGTGCAGAA GCGGCGGGTG 
CCCAACAAGC ATTATGTCTA CATCATCCGG GTCACGTGGT CCAGCGGCTC CACCGAGGCC 
ATTTACCGGC GCTACAGCAA GTTTTTTGAC CTCCAGATGC AGATGTTGGA CAAATTTCCC 
ATGGAAGGAG GACAGAAGGA CCCCAAGCAG CGGATCATCC CCTTTCTGCC AGGTAAGATT 
CTCTTCAGAC GAAGCCACAT CCGGGACGTG GCTGTCAAAC GCCTGATACC AATTGATGAA 
TACTGTAAGG CCCTCATCCA GCTGCCCCCC TACATCTCTC AGTGTGATGA GGTGCTGCAG 
TTCTTTGAGA CAAGACCTGA GGACCTGAAT CCCCCCAAAG AGGAGCACAT TGGGAAAAAG 
AAATCTGGGG GTGACCAAAC CTCAGTGGAC CCCATGGTCC TGGAGCAGTA TGTGGTGGTA 
GCCAACTACC AGAAGCAGGA GAGTTCGGAG ATCAGCCTCA GCGTGGGGCA GGTGGTGGAC 
ATCATCGAGA AGAATGAGTC AGGTTGGTGG TTCGTCAGCA CTGCCGAGGA GCAAGGCTGG 
GTCCCTGCAA CGTGCCTCGA AGGCCAGGAT GGGGTGCAGG ATGAGTTTTC TCTGCAGCCT 
GAAGAAGAGG AGAAGTACAC AGTCATCTAC CCGTACACAG CTCGGGACCA GGATGAAATG 
AACCTGGAGA GAGGGGCTGT GGTGGAGGTC ATCCAGAAAA ACCTGGAAGG CTGGTGGAAG 
ATCAGGTACC AGGGCAAAGA AGGCTGGGCC CCCGCCTCCT ACCTAAAGAA GAACAGTGGG 
GAGCCCTTGC CCCCGAAGCC AGGCCCTGGC TCACCCTCCC ACCCGGGTGC CCTTGACTTG 
GATGGTGTTT CCCGGCAGCA GAACGCGGTG GGCAGGGAGA AGGAGCTGCT CAGCAGCCAG 
AGGGACGGGC GGTTTGAAGG CCGCCCGGTG CCCGACGGTG ACGCCAAGCA GAGATCACCA 
AAGATGAGGC AGAGACCCCC TCCTCGCCGG GACATGACCA TTCCTCGAGG CCTCAACCTG 
CCGAAGCCGC CCATCCCGCC CCAAGTGGAG GAAGAGTATT ACACCATCGC CGAATTCCAG 
ACAACCATCC CAGACGGCAT CAGCTTCCAG GCAGGCCTGA AGGTCGAGGA TCATAAGAAT 
GTTCACTTGG AGAGCCCTGT GGAAGTCCCT CTTAGAAGAA TCAAGATGCG GACAGCACTT 
GGGAAGCACG TGGCAGCTTC CATGGAGATG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SH3PXD2B ( NM_001017995.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017995.1 Homo sapiens SH3 and PX domains 2B (SH3PXD2B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19671
Clone ID Related Accession (Same CDS sequence)	NM_001017995.3 , NM_001017995.2
Accession Version	NM_001017995.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2736bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	SH3 and PX domain-containing protein 2B isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC011407.6, AK128871.1, BC038561.1, AC090064.3, AC008671.6 and CA308160.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001017995.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ109556.1, AB430862.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000311601.6/ ENSP00000309714.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGCCGC GGCGCAGCAT CGTGGAGGTG AAGGTGCTAG ACGTGCAGAA GCGGCGGGTG 
CCCAACAAGC ATTATGTCTA CATCATCCGG GTCACGTGGT CCAGCGGCTC CACCGAGGCC 
ATTTACCGGC GCTACAGCAA GTTTTTTGAC CTCCAGATGC AGATGTTGGA CAAATTTCCC 
ATGGAAGGAG GACAGAAGGA CCCCAAGCAG CGGATCATCC CCTTTCTGCC AGGTAAGATT 
CTCTTCAGAC GAAGCCACAT CCGGGACGTG GCTGTCAAAC GCCTGATACC AATTGATGAA 
TACTGTAAGG CCCTCATCCA GCTGCCCCCC TACATCTCTC AGTGTGATGA GGTGCTGCAG 
TTCTTTGAGA CAAGACCTGA GGACCTGAAT CCCCCCAAAG AGGAGCACAT TGGGAAAAAG 
AAATCTGGGG GTGACCAAAC CTCAGTGGAC CCCATGGTCC TGGAGCAGTA TGTGGTGGTA 
GCCAACTACC AGAAGCAGGA GAGTTCGGAG ATCAGCCTCA GCGTGGGGCA GGTGGTGGAC 
ATCATCGAGA AGAATGAGTC AGGTTGGTGG TTCGTCAGCA CTGCCGAGGA GCAAGGCTGG 
GTCCCTGCAA CGTGCCTCGA AGGCCAGGAT GGGGTGCAGG ATGAGTTTTC TCTGCAGCCT 
GAAGAAGAGG AGAAGTACAC AGTCATCTAC CCGTACACAG CTCGGGACCA GGATGAAATG 
AACCTGGAGA GAGGGGCTGT GGTGGAGGTC ATCCAGAAAA ACCTGGAAGG CTGGTGGAAG 
ATCAGGTACC AGGGCAAAGA AGGCTGGGCC CCCGCCTCCT ACCTAAAGAA GAACAGTGGG 
GAGCCCTTGC CCCCGAAGCC AGGCCCTGGC TCACCCTCCC ACCCGGGTGC CCTTGACTTG 
GATGGTGTTT CCCGGCAGCA GAACGCGGTG GGCAGGGAGA AGGAGCTGCT CAGCAGCCAG 
AGGGACGGGC GGTTTGAAGG CCGCCCGGTG CCCGACGGTG ACGCCAAGCA GAGATCACCA 
AAGATGAGGC AGAGACCCCC TCCTCGCCGG GACATGACCA TTCCTCGAGG CCTCAACCTG 
CCGAAGCCGC CCATCCCGCC CCAAGTGGAG GAAGAGTATT ACACCATCGC CGAATTCCAG 
ACAACCATCC CAGACGGCAT CAGCTTCCAG GCAGGCCTGA AGGTCGAGGT GATCGAGAAA 
AACTTGAGTG GCTGGTGGTA CATTCAGATT GAAGATAAGG AAGGGTGGGC CCCGGCCACC 
TTCATTGACA AGTACAAGAA GACGAGCAAC GCGTCGAGAC CCAACTTTCT GGCTCCCCTG 
CCCCACGAGG TGACCCAGCT CCGGCTGGGG GAAGCAGCAG CGCTGGAGAA CAACACGGGC 
AGCGAAGCCA CGGGCCCCTC CCGGCCCCTG CCTGACGCAC CGCATGGTGT CATGGACTCG 
GGGTTGCCAT GGTCTAAAGA CTGGAAGGGC AGTAAGGATG TCCTGAGGAA GGCATCTTCA 
GACATGTCTG CGTCAGCAGG CTACGAGGAG ATCTCAGACC CCGACATGGA GGAGAAGCCC 
AGCCTCCCTC CGCGGAAAGA ATCCATCATC AAGTCGGAGG GGGAGCTGCT GGAGCGGGAG 
CGGGAGCGGC AGAGGACGGA GCAGCTCCGG GGCCCCACTC CCAAGCCTCC GGGCGTGATT 
TTGCCGATGA TGCCAGCCAA ACACATCCCT CCAGCCCGGG ACAGCAGGAG GCCAGAGCCC 
AAACCTGACA AAAGCAGACT GTTCCAGCTG AAAAATGACA TGGGGCTGGA GTGTGGCCAC 
AAGGTCTTGG CCAAGGAAGT GAAGAAGCCC AACCTCCGGC CCATCTCCAA ATCCAAAACT 
GACCTGCCAG AGGAGAAGCC AGATGCCACT CCCCAGAATC CCTTCTTGAA GTCCAGACCT 
CAGGTTAGGC CAAAACCAGC TCCTTCCCCC AAAACGGAGC CACCTCAGGG CGAAGACCAA 
GTCGACATCT GCAACCTCAG GAGTAAGCTC AGGCCTGCCA AGTCCCAAGA CAAGTCCTTG 
TTGGATGGGG AGGGCCCCCA GGCAGTAGGG GGCCAAGACG TGGCCTTCAG CCGAAGCTTC 
CTCCCAGGAG AGGGGCCTGG CCGCGCCCAG GACAGGACGG GCAAACAGGA TGGTCTCAGC 
CCAAAAGAGA TTTCCTGCAG AGCCCCTCCG AGGCCAGCCA AGACCACAGA TCCTGTGTCT 
AAGAGCGTGC CTGTTCCTCT CCAAGAGGCT CCCCAGCAGA GACCTGTGGT CCCACCCCGC 
AGACCACCTC CCCCAAAGAA AACCTCTTCG TCATCCAGGC CGCTCCCAGA GGTCAGAGGT 
CCACAGTGTG AAGGCCACGA AAGCAGGGCA GCTCCCACCC CAGGCCGTGC TCTCCTCGTC 
CCTCCAAAAG CCAAACCTTT TCTCTCCAAC TCTTTGGGGG GCCAGGATGA CACGCGAGGC 
AAAGGCAGCC TGGGGCCATG GGGGACCGGC AAGATTGGAG AAAACAGGGA GAAAGCAGCT 
GCAGCCTCTG TCCCCAATGC CGACGGCCTG AAGGACTCTT TGTATGTGGC CGTGGCCGAC 
TTTGAAGGAG ACAAAGACAC CAGCAGCTTC CAGGAAGGGA CAGTGTTTGA AGTCCGGGAG 
AAGAACAGCA GTGGCTGGTG GTTCTGCCAG GTCCTGAGCG GAGCCCCTTC CTGGGAAGGG 
TGGATTCCTT CCAACTATCT CAGAAAGAAG CCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017995.1
CDS	174..2909
Translation	MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP

Target ORF information:

RefSeq Version	NM_001017995.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SH3 and PX domains 2B (SH3PXD2B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017995.3

ORF Insert Sequence:

ATGCCGCCGC GGCGCAGCAT CGTGGAGGTG AAGGTGCTAG ACGTGCAGAA GCGGCGGGTG 
CCCAACAAGC ATTATGTCTA CATCATCCGG GTCACGTGGT CCAGCGGCTC CACCGAGGCC 
ATTTACCGGC GCTACAGCAA GTTTTTTGAC CTCCAGATGC AGATGTTGGA CAAATTTCCC 
ATGGAAGGAG GACAGAAGGA CCCCAAGCAG CGGATCATCC CCTTTCTGCC AGGTAAGATT 
CTCTTCAGAC GAAGCCACAT CCGGGACGTG GCTGTCAAAC GCCTGATACC AATTGATGAA 
TACTGTAAGG CCCTCATCCA GCTGCCCCCC TACATCTCTC AGTGTGATGA GGTGCTGCAG 
TTCTTTGAGA CAAGACCTGA GGACCTGAAT CCCCCCAAAG AGGAGCACAT TGGGAAAAAG 
AAATCTGGGG GTGACCAAAC CTCAGTGGAC CCCATGGTCC TGGAGCAGTA TGTGGTGGTA 
GCCAACTACC AGAAGCAGGA GAGTTCGGAG ATCAGCCTCA GCGTGGGGCA GGTGGTGGAC 
ATCATCGAGA AGAATGAGTC AGGTTGGTGG TTCGTCAGCA CTGCCGAGGA GCAAGGCTGG 
GTCCCTGCAA CGTGCCTCGA AGGCCAGGAT GGGGTGCAGG ATGAGTTTTC TCTGCAGCCT 
GAAGAAGAGG AGAAGTACAC AGTCATCTAC CCGTACACAG CTCGGGACCA GGATGAAATG 
AACCTGGAGA GAGGGGCTGT GGTGGAGGTC ATCCAGAAAA ACCTGGAAGG CTGGTGGAAG 
ATCAGGTACC AGGGCAAAGA AGGCTGGGCC CCCGCCTCCT ACCTAAAGAA GAACAGTGGG 
GAGCCCTTGC CCCCGAAGCC AGGCCCTGGC TCACCCTCCC ACCCGGGTGC CCTTGACTTG 
GATGGTGTTT CCCGGCAGCA GAACGCGGTG GGCAGGGAGA AGGAGCTGCT CAGCAGCCAG 
AGGGACGGGC GGTTTGAAGG CCGCCCGGTG CCCGACGGTG ACGCCAAGCA GAGATCACCA 
AAGATGAGGC AGAGACCCCC TCCTCGCCGG GACATGACCA TTCCTCGAGG CCTCAACCTG 
CCGAAGCCGC CCATCCCGCC CCAAGTGGAG GAAGAGTATT ACACCATCGC CGAATTCCAG 
ACAACCATCC CAGACGGCAT CAGCTTCCAG GCAGGCCTGA AGGTCGAGGT GATCGAGAAA 
AACTTGAGTG GCTGGTGGTA CATTCAGATT GAAGATAAGG AAGGGTGGGC CCCGGCCACC 
TTCATTGACA AGTACAAGAA GACGAGCAAC GCGTCGAGAC CCAACTTTCT GGCTCCCCTG 
CCCCACGAGG TGACCCAGCT CCGGCTGGGG GAAGCAGCAG CGCTGGAGAA CAACACGGGC 
AGCGAAGCCA CGGGCCCCTC CCGGCCCCTG CCTGACGCAC CGCATGGTGT CATGGACTCG 
GGGTTGCCAT GGTCTAAAGA CTGGAAGGGC AGTAAGGATG TCCTGAGGAA GGCATCTTCA 
GACATGTCTG CGTCAGCAGG CTACGAGGAG ATCTCAGACC CCGACATGGA GGAGAAGCCC 
AGCCTCCCTC CGCGGAAAGA ATCCATCATC AAGTCGGAGG GGGAGCTGCT GGAGCGGGAG 
CGGGAGCGGC AGAGGACGGA GCAGCTCCGG GGCCCCACTC CCAAGCCTCC GGGCGTGATT 
TTGCCGATGA TGCCAGCCAA ACACATCCCT CCAGCCCGGG ACAGCAGGAG GCCAGAGCCC 
AAACCTGACA AAAGCAGACT GTTCCAGCTG AAAAATGACA TGGGGCTGGA GTGTGGCCAC 
AAGGTCTTGG CCAAGGAAGT GAAGAAGCCC AACCTCCGGC CCATCTCCAA ATCCAAAACT 
GACCTGCCAG AGGAGAAGCC AGATGCCACT CCCCAGAATC CCTTCTTGAA GTCCAGACCT 
CAGGTTAGGC CAAAACCAGC TCCTTCCCCC AAAACGGAGC CACCTCAGGG CGAAGACCAA 
GTCGACATCT GCAACCTCAG GAGTAAGCTC AGGCCTGCCA AGTCCCAAGA CAAGTCCTTG 
TTGGATGGGG AGGGCCCCCA GGCAGTAGGG GGCCAAGACG TGGCCTTCAG CCGAAGCTTC 
CTCCCAGGAG AGGGGCCTGG CCGCGCCCAG GACAGGACGG GCAAACAGGA TGGTCTCAGC 
CCAAAAGAGA TTTCCTGCAG AGCCCCTCCG AGGCCAGCCA AGACCACAGA TCCTGTGTCT 
AAGAGCGTGC CTGTTCCTCT CCAAGAGGCT CCCCAGCAGA GACCTGTGGT CCCACCCCGC 
AGACCACCTC CCCCAAAGAA AACCTCTTCG TCATCCAGGC CGCTCCCAGA GGTCAGAGGT 
CCACAGTGTG AAGGCCACGA AAGCAGGGCA GCTCCCACCC CAGGCCGTGC TCTCCTCGTC 
CCTCCAAAAG CCAAACCTTT TCTCTCCAAC TCTTTGGGGG GCCAGGATGA CACGCGAGGC 
AAAGGCAGCC TGGGGCCATG GGGGACCGGC AAGATTGGAG AAAACAGGGA GAAAGCAGCT 
GCAGCCTCTG TCCCCAATGC CGACGGCCTG AAGGACTCTT TGTATGTGGC CGTGGCCGAC 
TTTGAAGGAG ACAAAGACAC CAGCAGCTTC CAGGAAGGGA CAGTGTTTGA AGTCCGGGAG 
AAGAACAGCA GTGGCTGGTG GTTCTGCCAG GTCCTGAGCG GAGCCCCTTC CTGGGAAGGG 
TGGATTCCTT CCAACTATCT CAGAAAGAAG CCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SH3PXD2B ( NM_001017995.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017995.1 Homo sapiens SH3 and PX domains 2B (SH3PXD2B), transcript variant 1, mRNA.

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CloneID	OHu19671
Clone ID Related Accession (Same CDS sequence)	NM_001017995.3 , NM_001017995.2
Accession Version	NM_001017995.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2736bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	SH3 and PX domain-containing protein 2B isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK128871.1, BC038561.1, AC090064.3, AC008671.6 and CA308160.1. This sequence is a reference standard in the RefSeqGene project. On Jan 3, 2009 this sequence version replaced NM_001017995.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ109556.1, AB430862.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGCCGC GGCGCAGCAT CGTGGAGGTG AAGGTGCTAG ACGTGCAGAA GCGGCGGGTG 
CCCAACAAGC ATTATGTCTA CATCATCCGG GTCACGTGGT CCAGCGGCTC CACCGAGGCC 
ATTTACCGGC GCTACAGCAA GTTTTTTGAC CTCCAGATGC AGATGTTGGA CAAATTTCCC 
ATGGAAGGAG GACAGAAGGA CCCCAAGCAG CGGATCATCC CCTTTCTGCC AGGTAAGATT 
CTCTTCAGAC GAAGCCACAT CCGGGACGTG GCTGTCAAAC GCCTGATACC AATTGATGAA 
TACTGTAAGG CCCTCATCCA GCTGCCCCCC TACATCTCTC AGTGTGATGA GGTGCTGCAG 
TTCTTTGAGA CAAGACCTGA GGACCTGAAT CCCCCCAAAG AGGAGCACAT TGGGAAAAAG 
AAATCTGGGG GTGACCAAAC CTCAGTGGAC CCCATGGTCC TGGAGCAGTA TGTGGTGGTA 
GCCAACTACC AGAAGCAGGA GAGTTCGGAG ATCAGCCTCA GCGTGGGGCA GGTGGTGGAC 
ATCATCGAGA AGAATGAGTC AGGTTGGTGG TTCGTCAGCA CTGCCGAGGA GCAAGGCTGG 
GTCCCTGCAA CGTGCCTCGA AGGCCAGGAT GGGGTGCAGG ATGAGTTTTC TCTGCAGCCT 
GAAGAAGAGG AGAAGTACAC AGTCATCTAC CCGTACACAG CTCGGGACCA GGATGAAATG 
AACCTGGAGA GAGGGGCTGT GGTGGAGGTC ATCCAGAAAA ACCTGGAAGG CTGGTGGAAG 
ATCAGGTACC AGGGCAAAGA AGGCTGGGCC CCCGCCTCCT ACCTAAAGAA GAACAGTGGG 
GAGCCCTTGC CCCCGAAGCC AGGCCCTGGC TCACCCTCCC ACCCGGGTGC CCTTGACTTG 
GATGGTGTTT CCCGGCAGCA GAACGCGGTG GGCAGGGAGA AGGAGCTGCT CAGCAGCCAG 
AGGGACGGGC GGTTTGAAGG CCGCCCGGTG CCCGACGGTG ACGCCAAGCA GAGATCACCA 
AAGATGAGGC AGAGACCCCC TCCTCGCCGG GACATGACCA TTCCTCGAGG CCTCAACCTG 
CCGAAGCCGC CCATCCCGCC CCAAGTGGAG GAAGAGTATT ACACCATCGC CGAATTCCAG 
ACAACCATCC CAGACGGCAT CAGCTTCCAG GCAGGCCTGA AGGTCGAGGT GATCGAGAAA 
AACTTGAGTG GCTGGTGGTA CATTCAGATT GAAGATAAGG AAGGGTGGGC CCCGGCCACC 
TTCATTGACA AGTACAAGAA GACGAGCAAC GCGTCGAGAC CCAACTTTCT GGCTCCCCTG 
CCCCACGAGG TGACCCAGCT CCGGCTGGGG GAAGCAGCAG CGCTGGAGAA CAACACGGGC 
AGCGAAGCCA CGGGCCCCTC CCGGCCCCTG CCTGACGCAC CGCATGGTGT CATGGACTCG 
GGGTTGCCAT GGTCTAAAGA CTGGAAGGGC AGTAAGGATG TCCTGAGGAA GGCATCTTCA 
GACATGTCTG CGTCAGCAGG CTACGAGGAG ATCTCAGACC CCGACATGGA GGAGAAGCCC 
AGCCTCCCTC CGCGGAAAGA ATCCATCATC AAGTCGGAGG GGGAGCTGCT GGAGCGGGAG 
CGGGAGCGGC AGAGGACGGA GCAGCTCCGG GGCCCCACTC CCAAGCCTCC GGGCGTGATT 
TTGCCGATGA TGCCAGCCAA ACACATCCCT CCAGCCCGGG ACAGCAGGAG GCCAGAGCCC 
AAACCTGACA AAAGCAGACT GTTCCAGCTG AAAAATGACA TGGGGCTGGA GTGTGGCCAC 
AAGGTCTTGG CCAAGGAAGT GAAGAAGCCC AACCTCCGGC CCATCTCCAA ATCCAAAACT 
GACCTGCCAG AGGAGAAGCC AGATGCCACT CCCCAGAATC CCTTCTTGAA GTCCAGACCT 
CAGGTTAGGC CAAAACCAGC TCCTTCCCCC AAAACGGAGC CACCTCAGGG CGAAGACCAA 
GTCGACATCT GCAACCTCAG GAGTAAGCTC AGGCCTGCCA AGTCCCAAGA CAAGTCCTTG 
TTGGATGGGG AGGGCCCCCA GGCAGTAGGG GGCCAAGACG TGGCCTTCAG CCGAAGCTTC 
CTCCCAGGAG AGGGGCCTGG CCGCGCCCAG GACAGGACGG GCAAACAGGA TGGTCTCAGC 
CCAAAAGAGA TTTCCTGCAG AGCCCCTCCG AGGCCAGCCA AGACCACAGA TCCTGTGTCT 
AAGAGCGTGC CTGTTCCTCT CCAAGAGGCT CCCCAGCAGA GACCTGTGGT CCCACCCCGC 
AGACCACCTC CCCCAAAGAA AACCTCTTCG TCATCCAGGC CGCTCCCAGA GGTCAGAGGT 
CCACAGTGTG AAGGCCACGA AAGCAGGGCA GCTCCCACCC CAGGCCGTGC TCTCCTCGTC 
CCTCCAAAAG CCAAACCTTT TCTCTCCAAC TCTTTGGGGG GCCAGGATGA CACGCGAGGC 
AAAGGCAGCC TGGGGCCATG GGGGACCGGC AAGATTGGAG AAAACAGGGA GAAAGCAGCT 
GCAGCCTCTG TCCCCAATGC CGACGGCCTG AAGGACTCTT TGTATGTGGC CGTGGCCGAC 
TTTGAAGGAG ACAAAGACAC CAGCAGCTTC CAGGAAGGGA CAGTGTTTGA AGTCCGGGAG 
AAGAACAGCA GTGGCTGGTG GTTCTGCCAG GTCCTGAGCG GAGCCCCTTC CTGGGAAGGG 
TGGATTCCTT CCAACTATCT CAGAAAGAAG CCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017995.1
CDS	172..2907
Translation	MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP

Target ORF information:

RefSeq Version	NM_001017995.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SH3 and PX domains 2B (SH3PXD2B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017995.2

ORF Insert Sequence:

ATGCCGCCGC GGCGCAGCAT CGTGGAGGTG AAGGTGCTAG ACGTGCAGAA GCGGCGGGTG 
CCCAACAAGC ATTATGTCTA CATCATCCGG GTCACGTGGT CCAGCGGCTC CACCGAGGCC 
ATTTACCGGC GCTACAGCAA GTTTTTTGAC CTCCAGATGC AGATGTTGGA CAAATTTCCC 
ATGGAAGGAG GACAGAAGGA CCCCAAGCAG CGGATCATCC CCTTTCTGCC AGGTAAGATT 
CTCTTCAGAC GAAGCCACAT CCGGGACGTG GCTGTCAAAC GCCTGATACC AATTGATGAA 
TACTGTAAGG CCCTCATCCA GCTGCCCCCC TACATCTCTC AGTGTGATGA GGTGCTGCAG 
TTCTTTGAGA CAAGACCTGA GGACCTGAAT CCCCCCAAAG AGGAGCACAT TGGGAAAAAG 
AAATCTGGGG GTGACCAAAC CTCAGTGGAC CCCATGGTCC TGGAGCAGTA TGTGGTGGTA 
GCCAACTACC AGAAGCAGGA GAGTTCGGAG ATCAGCCTCA GCGTGGGGCA GGTGGTGGAC 
ATCATCGAGA AGAATGAGTC AGGTTGGTGG TTCGTCAGCA CTGCCGAGGA GCAAGGCTGG 
GTCCCTGCAA CGTGCCTCGA AGGCCAGGAT GGGGTGCAGG ATGAGTTTTC TCTGCAGCCT 
GAAGAAGAGG AGAAGTACAC AGTCATCTAC CCGTACACAG CTCGGGACCA GGATGAAATG 
AACCTGGAGA GAGGGGCTGT GGTGGAGGTC ATCCAGAAAA ACCTGGAAGG CTGGTGGAAG 
ATCAGGTACC AGGGCAAAGA AGGCTGGGCC CCCGCCTCCT ACCTAAAGAA GAACAGTGGG 
GAGCCCTTGC CCCCGAAGCC AGGCCCTGGC TCACCCTCCC ACCCGGGTGC CCTTGACTTG 
GATGGTGTTT CCCGGCAGCA GAACGCGGTG GGCAGGGAGA AGGAGCTGCT CAGCAGCCAG 
AGGGACGGGC GGTTTGAAGG CCGCCCGGTG CCCGACGGTG ACGCCAAGCA GAGATCACCA 
AAGATGAGGC AGAGACCCCC TCCTCGCCGG GACATGACCA TTCCTCGAGG CCTCAACCTG 
CCGAAGCCGC CCATCCCGCC CCAAGTGGAG GAAGAGTATT ACACCATCGC CGAATTCCAG 
ACAACCATCC CAGACGGCAT CAGCTTCCAG GCAGGCCTGA AGGTCGAGGT GATCGAGAAA 
AACTTGAGTG GCTGGTGGTA CATTCAGATT GAAGATAAGG AAGGGTGGGC CCCGGCCACC 
TTCATTGACA AGTACAAGAA GACGAGCAAC GCGTCGAGAC CCAACTTTCT GGCTCCCCTG 
CCCCACGAGG TGACCCAGCT CCGGCTGGGG GAAGCAGCAG CGCTGGAGAA CAACACGGGC 
AGCGAAGCCA CGGGCCCCTC CCGGCCCCTG CCTGACGCAC CGCATGGTGT CATGGACTCG 
GGGTTGCCAT GGTCTAAAGA CTGGAAGGGC AGTAAGGATG TCCTGAGGAA GGCATCTTCA 
GACATGTCTG CGTCAGCAGG CTACGAGGAG ATCTCAGACC CCGACATGGA GGAGAAGCCC 
AGCCTCCCTC CGCGGAAAGA ATCCATCATC AAGTCGGAGG GGGAGCTGCT GGAGCGGGAG 
CGGGAGCGGC AGAGGACGGA GCAGCTCCGG GGCCCCACTC CCAAGCCTCC GGGCGTGATT 
TTGCCGATGA TGCCAGCCAA ACACATCCCT CCAGCCCGGG ACAGCAGGAG GCCAGAGCCC 
AAACCTGACA AAAGCAGACT GTTCCAGCTG AAAAATGACA TGGGGCTGGA GTGTGGCCAC 
AAGGTCTTGG CCAAGGAAGT GAAGAAGCCC AACCTCCGGC CCATCTCCAA ATCCAAAACT 
GACCTGCCAG AGGAGAAGCC AGATGCCACT CCCCAGAATC CCTTCTTGAA GTCCAGACCT 
CAGGTTAGGC CAAAACCAGC TCCTTCCCCC AAAACGGAGC CACCTCAGGG CGAAGACCAA 
GTCGACATCT GCAACCTCAG GAGTAAGCTC AGGCCTGCCA AGTCCCAAGA CAAGTCCTTG 
TTGGATGGGG AGGGCCCCCA GGCAGTAGGG GGCCAAGACG TGGCCTTCAG CCGAAGCTTC 
CTCCCAGGAG AGGGGCCTGG CCGCGCCCAG GACAGGACGG GCAAACAGGA TGGTCTCAGC 
CCAAAAGAGA TTTCCTGCAG AGCCCCTCCG AGGCCAGCCA AGACCACAGA TCCTGTGTCT 
AAGAGCGTGC CTGTTCCTCT CCAAGAGGCT CCCCAGCAGA GACCTGTGGT CCCACCCCGC 
AGACCACCTC CCCCAAAGAA AACCTCTTCG TCATCCAGGC CGCTCCCAGA GGTCAGAGGT 
CCACAGTGTG AAGGCCACGA AAGCAGGGCA GCTCCCACCC CAGGCCGTGC TCTCCTCGTC 
CCTCCAAAAG CCAAACCTTT TCTCTCCAAC TCTTTGGGGG GCCAGGATGA CACGCGAGGC 
AAAGGCAGCC TGGGGCCATG GGGGACCGGC AAGATTGGAG AAAACAGGGA GAAAGCAGCT 
GCAGCCTCTG TCCCCAATGC CGACGGCCTG AAGGACTCTT TGTATGTGGC CGTGGCCGAC 
TTTGAAGGAG ACAAAGACAC CAGCAGCTTC CAGGAAGGGA CAGTGTTTGA AGTCCGGGAG 
AAGAACAGCA GTGGCTGGTG GTTCTGCCAG GTCCTGAGCG GAGCCCCTTC CTGGGAAGGG 
TGGATTCCTT CCAACTATCT CAGAAAGAAG CCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SH3PXD2B ( XM_017009351.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016864840.1 Homo sapiens SH3 and PX domains 2B (SH3PXD2B), transcript variant X1, mRNA.

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CloneID	OHu95828
Clone ID Related Accession (Same CDS sequence)	XM_017009351.1
Accession Version	XM_017009351.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2820bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	SH3 and PX domain-containing protein 2B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGCCGC GGCGCAGCAT CGTGGAGGTG AAGGTGCTAG ACGTGCAGAA GCGGCGGGTG 
CCCAACAAGC ATTATGTCTA CATCATCCGG GTCACGTGGT CCAGCGGCTC CACCGAGGCC 
ATTTACCGGC GCTACAGCAA GTTTTTTGAC CTCCAGATGC AGATGTTGGA CAAATTTCCC 
ATGGAAGGAG GACAGAAGGA CCCCAAGCAG CGGATCATCC CCTTTCTGCC AGGTAAGATT 
CTCTTCAGAC GAAGCCACAT CCGGGACGTG GCTGTCAAAC GCCTGATACC AATTGATGAA 
TACTGTAAGG CCCTCATCCA GCTGCCCCCC TACATCTCTC AGTGTGATGA GGTGCTGCAG 
TTCTTTGAGA CAAGACCTGA GGACCTGAAT CCCCCCAAAG AGGAGCACAT TGGGAAAAAG 
AAATCTGGGG GTGACCAAAC CTCAGTGGAC CCCATGGTCC TGGAGCAGTA TGTGGTGGTA 
GCCAACTACC AGAAGCAGGA GAGTTCGGAG ATCAGCCTCA GCGTGGGGCA GGTGGTGGAC 
ATCATCGAGA AGAATGAGTC AGGTTGGTGG TTCGTCAGCA CTGCCGAGGA GCAAGGCTGG 
GTCCCTGCAA CGTGCCTCGA AGGCCAGGAT GGGGTGCAGG ATGAGTTTTC TCTGCAGCCT 
GAAGAAGTCT CATGGAGGTA TTGGTCTCTG CCCCGGCCGG TGGGCCGCCG CCGGACTCTG 
GGGGACTTGT ATGCCATCAG CTGGCGTCAA GAGGAGAAGT ACACAGTCAT CTACCCGTAC 
ACAGCTCGGG ACCAGGATGA AATGAACCTG GAGAGAGGGG CTGTGGTGGA GGTCATCCAG 
AAAAACCTGG AAGGCTGGTG GAAGATCAGG TACCAGGGCA AAGAAGGCTG GGCCCCCGCC 
TCCTACCTAA AGAAGAACAG TGGGGAGCCC TTGCCCCCGA AGCCAGGCCC TGGCTCACCC 
TCCCACCCGG GTGCCCTTGA CTTGGATGGT GTTTCCCGGC AGCAGAACGC GGTGGGCAGG 
GAGAAGGAGC TGCTCAGCAG CCAGAGGGAC GGGCGGTTTG AAGGCCGCCC GGTGCCCGAC 
GGTGACGCCA AGCAGAGATC ACCAAAGATG AGGCAGAGAC CCCCTCCTCG CCGGGACATG 
ACCATTCCTC GAGGCCTCAA CCTGCCGAAG CCGCCCATCC CGCCCCAAGT GGAGGAAGAG 
TATTACACCA TCGCCGAATT CCAGACAACC ATCCCAGACG GCATCAGCTT CCAGGCAGGC 
CTGAAGGTCG AGGTGATCGA GAAAAACTTG AGTGGCTGGT GGTACATTCA GATTGAAGAT 
AAGGAAGGGT GGGCCCCGGC CACCTTCATT GACAAGTACA AGAAGACGAG CAACGCGTCG 
AGACCCAACT TTCTGGCTCC CCTGCCCCAC GAGGTGACCC AGCTCCGGCT GGGGGAAGCA 
GCAGCGCTGG AGAACAACAC GGGCAGCGAA GCCACGGGCC CCTCCCGGCC CCTGCCTGAC 
GCACCGCATG GTGTCATGGA CTCGGGGTTG CCATGGTCTA AAGACTGGAA GGGCAGTAAG 
GATGTCCTGA GGAAGGCATC TTCAGACATG TCTGCGTCAG CAGGCTACGA GGAGATCTCA 
GACCCCGACA TGGAGGAGAA GCCCAGCCTC CCTCCGCGGA AAGAATCCAT CATCAAGTCG 
GAGGGGGAGC TGCTGGAGCG GGAGCGGGAG CGGCAGAGGA CGGAGCAGCT CCGGGGCCCC 
ACTCCCAAGC CTCCGGGCGT GATTTTGCCG ATGATGCCAG CCAAACACAT CCCTCCAGCC 
CGGGACAGCA GGAGGCCAGA GCCCAAACCT GACAAAAGCA GACTGTTCCA GCTGAAAAAT 
GACATGGGGC TGGAGTGTGG CCACAAGGTC TTGGCCAAGG AAGTGAAGAA GCCCAACCTC 
CGGCCCATCT CCAAATCCAA AACTGACCTG CCAGAGGAGA AGCCAGATGC CACTCCCCAG 
AATCCCTTCT TGAAGTCCAG ACCTCAGGTT AGGCCAAAAC CAGCTCCTTC CCCCAAAACG 
GAGCCACCTC AGGGCGAAGA CCAAGTCGAC ATCTGCAACC TCAGGAGTAA GCTCAGGCCT 
GCCAAGTCCC AAGACAAGTC CTTGTTGGAT GGGGAGGGCC CCCAGGCAGT AGGGGGCCAA 
GACGTGGCCT TCAGCCGAAG CTTCCTCCCA GGAGAGGGGC CTGGCCGCGC CCAGGACAGG 
ACGGGCAAAC AGGATGGTCT CAGCCCAAAA GAGATTTCCT GCAGAGCCCC TCCGAGGCCA 
GCCAAGACCA CAGATCCTGT GTCTAAGAGC GTGCCTGTTC CTCTCCAAGA GGCTCCCCAG 
CAGAGACCTG TGGTCCCACC CCGCAGACCA CCTCCCCCAA AGAAAACCTC TTCGTCATCC 
AGGCCGCTCC CAGAGGTCAG AGGTCCACAG TGTGAAGGCC ACGAAAGCAG GGCAGCTCCC 
ACCCCAGGCC GTGCTCTCCT CGTCCCTCCA AAAGCCAAAC CTTTTCTCTC CAACTCTTTG 
GGGGGCCAGG ATGACACGCG AGGCAAAGGC AGCCTGGGGC CATGGGGGAC CGGCAAGATT 
GGAGAAAACA GGGAGAAAGC AGCTGCAGCC TCTGTCCCCA ATGCCGACGG CCTGAAGGAC 
TCTTTGTATG TGGCCGTGGC CGACTTTGAA GGAGACAAAG ACACCAGCAG CTTCCAGGAA 
GGGACAGTGT TTGAAGTCCG GGAGAAGAAC AGCAGTGGCT GGTGGTTCTG CCAGGTCCTG 
AGCGGAGCCC CTTCCTGGGA AGGGTGGATT CCTTCCAACT ATCTCAGAAA GAAGCCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016864840.1
CDS	172..2991
Translation	MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEVSWRYWSLPRPVGRRRTLGDLYAISWRQEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP

Target ORF information:

RefSeq Version	XM_017009351.1
Organism	Homo sapiens(human)
Definition	Homo sapiens SH3 and PX domains 2B (SH3PXD2B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017009351.1

ORF Insert Sequence:

ATGCCGCCGC GGCGCAGCAT CGTGGAGGTG AAGGTGCTAG ACGTGCAGAA GCGGCGGGTG 
CCCAACAAGC ATTATGTCTA CATCATCCGG GTCACGTGGT CCAGCGGCTC CACCGAGGCC 
ATTTACCGGC GCTACAGCAA GTTTTTTGAC CTCCAGATGC AGATGTTGGA CAAATTTCCC 
ATGGAAGGAG GACAGAAGGA CCCCAAGCAG CGGATCATCC CCTTTCTGCC AGGTAAGATT 
CTCTTCAGAC GAAGCCACAT CCGGGACGTG GCTGTCAAAC GCCTGATACC AATTGATGAA 
TACTGTAAGG CCCTCATCCA GCTGCCCCCC TACATCTCTC AGTGTGATGA GGTGCTGCAG 
TTCTTTGAGA CAAGACCTGA GGACCTGAAT CCCCCCAAAG AGGAGCACAT TGGGAAAAAG 
AAATCTGGGG GTGACCAAAC CTCAGTGGAC CCCATGGTCC TGGAGCAGTA TGTGGTGGTA 
GCCAACTACC AGAAGCAGGA GAGTTCGGAG ATCAGCCTCA GCGTGGGGCA GGTGGTGGAC 
ATCATCGAGA AGAATGAGTC AGGTTGGTGG TTCGTCAGCA CTGCCGAGGA GCAAGGCTGG 
GTCCCTGCAA CGTGCCTCGA AGGCCAGGAT GGGGTGCAGG ATGAGTTTTC TCTGCAGCCT 
GAAGAAGTCT CATGGAGGTA TTGGTCTCTG CCCCGGCCGG TGGGCCGCCG CCGGACTCTG 
GGGGACTTGT ATGCCATCAG CTGGCGTCAA GAGGAGAAGT ACACAGTCAT CTACCCGTAC 
ACAGCTCGGG ACCAGGATGA AATGAACCTG GAGAGAGGGG CTGTGGTGGA GGTCATCCAG 
AAAAACCTGG AAGGCTGGTG GAAGATCAGG TACCAGGGCA AAGAAGGCTG GGCCCCCGCC 
TCCTACCTAA AGAAGAACAG TGGGGAGCCC TTGCCCCCGA AGCCAGGCCC TGGCTCACCC 
TCCCACCCGG GTGCCCTTGA CTTGGATGGT GTTTCCCGGC AGCAGAACGC GGTGGGCAGG 
GAGAAGGAGC TGCTCAGCAG CCAGAGGGAC GGGCGGTTTG AAGGCCGCCC GGTGCCCGAC 
GGTGACGCCA AGCAGAGATC ACCAAAGATG AGGCAGAGAC CCCCTCCTCG CCGGGACATG 
ACCATTCCTC GAGGCCTCAA CCTGCCGAAG CCGCCCATCC CGCCCCAAGT GGAGGAAGAG 
TATTACACCA TCGCCGAATT CCAGACAACC ATCCCAGACG GCATCAGCTT CCAGGCAGGC 
CTGAAGGTCG AGGTGATCGA GAAAAACTTG AGTGGCTGGT GGTACATTCA GATTGAAGAT 
AAGGAAGGGT GGGCCCCGGC CACCTTCATT GACAAGTACA AGAAGACGAG CAACGCGTCG 
AGACCCAACT TTCTGGCTCC CCTGCCCCAC GAGGTGACCC AGCTCCGGCT GGGGGAAGCA 
GCAGCGCTGG AGAACAACAC GGGCAGCGAA GCCACGGGCC CCTCCCGGCC CCTGCCTGAC 
GCACCGCATG GTGTCATGGA CTCGGGGTTG CCATGGTCTA AAGACTGGAA GGGCAGTAAG 
GATGTCCTGA GGAAGGCATC TTCAGACATG TCTGCGTCAG CAGGCTACGA GGAGATCTCA 
GACCCCGACA TGGAGGAGAA GCCCAGCCTC CCTCCGCGGA AAGAATCCAT CATCAAGTCG 
GAGGGGGAGC TGCTGGAGCG GGAGCGGGAG CGGCAGAGGA CGGAGCAGCT CCGGGGCCCC 
ACTCCCAAGC CTCCGGGCGT GATTTTGCCG ATGATGCCAG CCAAACACAT CCCTCCAGCC 
CGGGACAGCA GGAGGCCAGA GCCCAAACCT GACAAAAGCA GACTGTTCCA GCTGAAAAAT 
GACATGGGGC TGGAGTGTGG CCACAAGGTC TTGGCCAAGG AAGTGAAGAA GCCCAACCTC 
CGGCCCATCT CCAAATCCAA AACTGACCTG CCAGAGGAGA AGCCAGATGC CACTCCCCAG 
AATCCCTTCT TGAAGTCCAG ACCTCAGGTT AGGCCAAAAC CAGCTCCTTC CCCCAAAACG 
GAGCCACCTC AGGGCGAAGA CCAAGTCGAC ATCTGCAACC TCAGGAGTAA GCTCAGGCCT 
GCCAAGTCCC AAGACAAGTC CTTGTTGGAT GGGGAGGGCC CCCAGGCAGT AGGGGGCCAA 
GACGTGGCCT TCAGCCGAAG CTTCCTCCCA GGAGAGGGGC CTGGCCGCGC CCAGGACAGG 
ACGGGCAAAC AGGATGGTCT CAGCCCAAAA GAGATTTCCT GCAGAGCCCC TCCGAGGCCA 
GCCAAGACCA CAGATCCTGT GTCTAAGAGC GTGCCTGTTC CTCTCCAAGA GGCTCCCCAG 
CAGAGACCTG TGGTCCCACC CCGCAGACCA CCTCCCCCAA AGAAAACCTC TTCGTCATCC 
AGGCCGCTCC CAGAGGTCAG AGGTCCACAG TGTGAAGGCC ACGAAAGCAG GGCAGCTCCC 
ACCCCAGGCC GTGCTCTCCT CGTCCCTCCA AAAGCCAAAC CTTTTCTCTC CAACTCTTTG 
GGGGGCCAGG ATGACACGCG AGGCAAAGGC AGCCTGGGGC CATGGGGGAC CGGCAAGATT 
GGAGAAAACA GGGAGAAAGC AGCTGCAGCC TCTGTCCCCA ATGCCGACGG CCTGAAGGAC 
TCTTTGTATG TGGCCGTGGC CGACTTTGAA GGAGACAAAG ACACCAGCAG CTTCCAGGAA 
GGGACAGTGT TTGAAGTCCG GGAGAAGAAC AGCAGTGGCT GGTGGTTCTG CCAGGTCCTG 
AGCGGAGCCC CTTCCTGGGA AGGGTGGATT CCTTCCAACT ATCTCAGAAA GAAGCCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ophthalmic findings in Frank-ter Haar syndrome: report of a sibling pair.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus21(6)514-516(2017 Dec)
Chang TC,Bauer M,Puerta HS,Greenberg MB,Cavuoto KM

The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.
Oncotarget7(48)78473-78486(2016 Nov)
Iizuka S,Abdullah C,Buschman MD,Diaz B,Courtneidge SA

Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes.
Cell communication and signaling : CCS1333(2015 Jul)
?d?m C,Fekete A,B?gel G,N?meth Z,T?k?si N,Ov?di J,Liliom K,Pesti S,Geiszt M,Buday L

Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults.
PloS one9(8)e105062(2014)
Scannell Bryan M,Argos M,Pierce B,Tong L,Rakibuz-Zaman M,Ahmed A,Rahman M,Islam T,Yunus M,Parvez F,Roy S,Jasmine F,Baron JA,Kibriya MG,Ahsan H

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SH3PXD2B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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