MCHR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MCHR1
Entrez Gene ID	2847
Full Name	melanin concentrating hormone receptor 1
Synonyms	GPR24,MCH-1R,MCH1R,SLC-1,SLC1
General protein information	Preferred Names melanin concentrating hormone receptor 1 Names melanin-concentrating hormone receptor 1 G protein-coupled receptor 24 MCH receptor 1 somatostatin receptor-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.2
Summary	The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008].
Disorder MIM:	601751

mRNA and Protein(s)

mRNA	Protein	Name
NM_005297.3	NP_005288.3	melanin-concentrating hormone receptor 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	MCHR1	NP_005288.3
Pan troglodytes (chimpanzee)	MCHR1	NP_001012440.1
Canis lupus familiaris (dog)	MCHR1	NP_001003038.1
Bos taurus (cattle)	MCHR1	NP_001096762.1
Rattus norvegicus (Norway rat)	Mchr1	NP_113946.1
Xenopus tropicalis (tropical clawed frog)	mchr1.2	NP_001072243.1
Danio rerio (zebrafish)	mchr1b	XP_692413.3
Danio rerio (zebrafish)	mchr1a	XP_001343144.1
	MCHR1	NP_001028057.1
Mus musculus (house mouse)	Mchr1	NP_660114.1
Gallus gallus (chicken)	LOC100859572	XP_004946431.1

Gene Ontology
Bibliography

Related articles in PubMed

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
Badgandi HB, Hwang SH, Shimada IS, Loriot E, Mukhopadhyay S
The Journal of cell biology216(3)743-760(2017 Mar)

Melanin-concentrating hormone receptor 1 polymorphisms are associated with components of energy balance in the Complex Diseases in the Newfoundland Population: Environment and Genetics (CODING) study.
Fontaine-Bisson B, Thorburn J, Gregory A, Zhang H, Sun G
The American journal of clinical nutrition99(2)384-91(2014 Feb)

The gene encoding the melanin-concentrating hormone receptor 1 is associated with schizophrenia in a Danish case-control sample.
Demontis D, Nyegaard M, Christensen JH, Severinsen J, Hedemand A, Hansen T, Werge T, Mors O, B?rglum AD
Psychiatric genetics22(2)62-9(2012 Apr)

Microarray-based mutation detection of pediatric sporadic nonsyndromic hearing loss in China.
Qu C, Sun X, Shi Y, Gong A, Liang S, Zhao M, Chen Y, Liang F
International journal of pediatric otorhinolaryngology76(2)235-9(2012 Feb)

Allele-specific, age-dependent and BMI-associated DNA methylation of human MCHR1.
Stepanow S, Reichwald K, Huse K, Gausmann U, Nebel A, Rosenstiel P, Wabitsch M, Fischer-Posovszky P, Platzer M
PloS one6(5)e17711(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Polymorphisms in the MCHR1 gene are associated with differences in body composition and interact with physiologic and energy-related lifestyle factors.
Title: Melanin-concentrating hormone receptor 1 polymorphisms are associated with components of energy balance in the Complex Diseases in the Newfoundland Population: Environment and Genetics (CODING) study.

results suggest that MCHR1 may influence schizophrenia susceptibility, in particular among men and patients responding to conventional (nonclozapine) treatment
Title: The gene encoding the melanin-concentrating hormone receptor 1 is associated with schizophrenia in a Danish case-control sample.

SLC-1 protein human mutation demonstrated important genetic susceptibility of sporadic nonsyndromic hearing loss in China.
Title: Microarray-based mutation detection of pediatric sporadic nonsyndromic hearing loss in China.

DNA methylation at MCHR1 is allele-specific, age-dependent, body mass index-associated and affects transcription.
Title: Allele-specific, age-dependent and BMI-associated DNA methylation of human MCHR1.

MCHR1 expression level was 1.6 times higher in vitiligo uninvolved skin (P < 0.05) and 2.23 times lower in involved skin (P < 0.05), when compared to healthy control skin.
Title: Analysis of the expression profile of CRH-POMC system genes in vitiligo skin biopsies.

The following MCHR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MCHR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18174	NM_005297.3 Latest version!	Homo sapiens melanin concentrating hormone receptor 1 (MCHR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MCHR1 ( NM_005297.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005288.3 Homo sapiens melanin concentrating hormone receptor 1 (MCHR1), mRNA.

Price & Availability↑

CloneID	OHu18174
Clone ID Related Accession (Same CDS sequence)	NM_005297.3
Accession Version	NM_005297.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1269bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	melanin-concentrating hormone receptor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z86090.10 and AF490537.2. This sequence is a reference standard in the RefSeqGene project. On Feb 23, 2006 this sequence version replaced NM_005297.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF490537.2, SRR1803613.193448.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCAGTGG GAGCCATGAA GAAGGGAGTG GGGAGGGCAG TTGGGCTTGG AGGCGGCAGC 
GGCTGCCAGG CTACGGAGGA AGACCCCCTT CCCAACTGCG GGGCTTGCGC TCCGGGACAA 
GGTGGCAGGC GCTGGAGGCT GCCGCAGCCT GCGTGGGTGG AGGGGAGCTC AGCTCGGTTG 
TGGGAGCAGG CGACCGGCAC TGGCTGGATG GACCTGGAAG CCTCGCTGCT GCCCACTGGT 
CCCAACGCCA GCAACACCTC TGATGGCCCC GATAACCTCA CTTCGGCAGG ATCACCTCCT 
CGCACGGGGA GCATCTCCTA CATCAACATC ATCATGCCTT CGGTGTTCGG CACCATCTGC 
CTCCTGGGCA TCATCGGGAA CTCCACGGTC ATCTTCGCGG TCGTGAAGAA GTCCAAGCTG 
CACTGGTGCA ACAACGTCCC CGACATCTTC ATCATCAACC TCTCGGTAGT AGATCTCCTC 
TTTCTCCTGG GCATGCCCTT CATGATCCAC CAGCTCATGG GCAATGGGGT GTGGCACTTT 
GGGGAGACCA TGTGCACCCT CATCACGGCC ATGGATGCCA ATAGTCAGTT CACCAGCACC 
TACATCCTGA CCGCCATGGC CATTGACCGC TACCTGGCCA CTGTCCACCC CATCTCTTCC 
ACGAAGTTCC GGAAGCCCTC TGTGGCCACC CTGGTGATCT GCCTCCTGTG GGCCCTCTCC 
TTCATCAGCA TCACCCCTGT GTGGCTGTAT GCCAGACTCA TCCCCTTCCC AGGAGGTGCA 
GTGGGCTGCG GCATACGCCT GCCCAACCCA GACACTGACC TCTACTGGTT CACCCTGTAC 
CAGTTTTTCC TGGCCTTTGC CCTGCCTTTT GTGGTCATCA CAGCCGCATA CGTGAGGATC 
CTGCAGCGCA TGACGTCCTC AGTGGCCCCC GCCTCCCAGC GCAGCATCCG GCTGCGGACA 
AAGAGGGTGA CCCGCACAGC CATCGCCATC TGTCTGGTCT TCTTTGTGTG CTGGGCACCC 
TACTATGTGC TACAGCTGAC CCAGTTGTCC ATCAGCCGCC CGACCCTCAC CTTTGTCTAC 
TTATACAATG CGGCCATCAG CTTGGGCTAT GCCAACAGCT GCCTCAACCC CTTTGTGTAC 
ATCGTGCTCT GTGAGACGTT CCGCAAACGC TTGGTCCTGT CGGTGAAGCC TGCAGCCCAG 
GGGCAGCTTC GCGCTGTCAG CAACGCTCAG ACGGCTGACG AGGAGAGGAC AGAAAGCAAA 
GGCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005288.3
CDS	269..1537
Translation	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT

Target ORF information:

RefSeq Version	NM_005297.3
Organism	Homo sapiens(human)
Definition	Homo sapiens melanin concentrating hormone receptor 1 (MCHR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005297.3

ORF Insert Sequence:

ATGTCAGTGG GAGCCATGAA GAAGGGAGTG GGGAGGGCAG TTGGGCTTGG AGGCGGCAGC 
GGCTGCCAGG CTACGGAGGA AGACCCCCTT CCCAACTGCG GGGCTTGCGC TCCGGGACAA 
GGTGGCAGGC GCTGGAGGCT GCCGCAGCCT GCGTGGGTGG AGGGGAGCTC AGCTCGGTTG 
TGGGAGCAGG CGACCGGCAC TGGCTGGATG GACCTGGAAG CCTCGCTGCT GCCCACTGGT 
CCCAACGCCA GCAACACCTC TGATGGCCCC GATAACCTCA CTTCGGCAGG ATCACCTCCT 
CGCACGGGGA GCATCTCCTA CATCAACATC ATCATGCCTT CGGTGTTCGG CACCATCTGC 
CTCCTGGGCA TCATCGGGAA CTCCACGGTC ATCTTCGCGG TCGTGAAGAA GTCCAAGCTG 
CACTGGTGCA ACAACGTCCC CGACATCTTC ATCATCAACC TCTCGGTAGT AGATCTCCTC 
TTTCTCCTGG GCATGCCCTT CATGATCCAC CAGCTCATGG GCAATGGGGT GTGGCACTTT 
GGGGAGACCA TGTGCACCCT CATCACGGCC ATGGATGCCA ATAGTCAGTT CACCAGCACC 
TACATCCTGA CCGCCATGGC CATTGACCGC TACCTGGCCA CTGTCCACCC CATCTCTTCC 
ACGAAGTTCC GGAAGCCCTC TGTGGCCACC CTGGTGATCT GCCTCCTGTG GGCCCTCTCC 
TTCATCAGCA TCACCCCTGT GTGGCTGTAT GCCAGACTCA TCCCCTTCCC AGGAGGTGCA 
GTGGGCTGCG GCATACGCCT GCCCAACCCA GACACTGACC TCTACTGGTT CACCCTGTAC 
CAGTTTTTCC TGGCCTTTGC CCTGCCTTTT GTGGTCATCA CAGCCGCATA CGTGAGGATC 
CTGCAGCGCA TGACGTCCTC AGTGGCCCCC GCCTCCCAGC GCAGCATCCG GCTGCGGACA 
AAGAGGGTGA CCCGCACAGC CATCGCCATC TGTCTGGTCT TCTTTGTGTG CTGGGCACCC 
TACTATGTGC TACAGCTGAC CCAGTTGTCC ATCAGCCGCC CGACCCTCAC CTTTGTCTAC 
TTATACAATG CGGCCATCAG CTTGGGCTAT GCCAACAGCT GCCTCAACCC CTTTGTGTAC 
ATCGTGCTCT GTGAGACGTT CCGCAAACGC TTGGTCCTGT CGGTGAAGCC TGCAGCCCAG 
GGGCAGCTTC GCGCTGTCAG CAACGCTCAG ACGGCTGACG AGGAGAGGAC AGAAAGCAAA 
GGCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
The Journal of cell biology216(3)743-760(2017 Mar)
Badgandi HB,Hwang SH,Shimada IS,Loriot E,Mukhopadhyay S

Melanin-concentrating hormone receptor 1 polymorphisms are associated with components of energy balance in the Complex Diseases in the Newfoundland Population: Environment and Genetics (CODING) study.
The American journal of clinical nutrition99(2)384-91(2014 Feb)
Fontaine-Bisson B,Thorburn J,Gregory A,Zhang H,Sun G

The gene encoding the melanin-concentrating hormone receptor 1 is associated with schizophrenia in a Danish case-control sample.
Psychiatric genetics22(2)62-9(2012 Apr)
Demontis D,Nyegaard M,Christensen JH,Severinsen J,Hedemand A,Hansen T,Werge T,Mors O,B?rglum AD

Microarray-based mutation detection of pediatric sporadic nonsyndromic hearing loss in China.
International journal of pediatric otorhinolaryngology76(2)235-9(2012 Feb)
Qu C,Sun X,Shi Y,Gong A,Liang S,Zhao M,Chen Y,Liang F

Allele-specific, age-dependent and BMI-associated DNA methylation of human MCHR1.
PloS one6(5)e17711(2011)
Stepanow S,Reichwald K,Huse K,Gausmann U,Nebel A,Rosenstiel P,Wabitsch M,Fischer-Posovszky P,Platzer M

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MCHR1 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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