CYP4A22 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CYP4A22
Entrez Gene ID	284541
Full Name	cytochrome P450 family 4 subfamily A member 22
General protein information	Preferred Names cytochrome P450 family 4 subfamily A member 22 Names cytochrome P450 4A22 CYPIVA22 cytochrome P450 4A22K cytochrome P450, family 4, subfamily A, polypeptide 22 fatty acid omega-hydroxylase lauric acid omega-hydroxylase long-chain fatty acid omega-monooxygenase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p33
Summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Disorder MIM:	615341

mRNA and Protein(s)

mRNA	Protein	Name
XM_005270770.3	XP_005270827.1	cytochrome P450 4A22 isoform X2
NM_001010969.4	NP_001010969.2	cytochrome P450 4A22 isoform 1
NM_001308102.1	NP_001295031.1	cytochrome P450 4A22 isoform 2
NM_001010969.3	NP_001010969.2	cytochrome P450 4A22 isoform 1
XM_005270767.3	XP_005270824.1	cytochrome P450 4A22 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CYP4A11	NP_001071376.1
Canis lupus familiaris (dog)	CYP4A11	NP_001041499.1
Homo sapiens (human)	CYP4A22	NP_001010969.2
	LOC709461	XP_001109135.1
Canis lupus familiaris (dog)	CYP4A38	NP_001041482.1
Canis lupus familiaris (dog)	CYP4A37	NP_001041490.1
Bos taurus (cattle)	CYP4A22	NP_001092460.1
Mus musculus (house mouse)	Cyp4a12a	NP_803125.2
Mus musculus (house mouse)	Cyp4a12b	NP_758510.2
Rattus norvegicus (Norway rat)	Cyp4a8	NP_113793.2
Pan troglodytes (chimpanzee)	LOC456835	XP_513388.2
Gallus gallus (chicken)	CYP4B1	XP_422455.2
Arabidopsis thaliana (thale cress)	CYP715A1	NP_200053.2
Oryza sativa (rice)	Os02g0824100	NP_001048573.1

Gene Ontology
Bibliography

Related articles in PubMed

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
Goldstein JI, Jarskog LF, Hilliard C, Alfirevic A, Duncan L, Fourches D, Huang H, Lek M, Neale BM, Ripke S, Shianna K, Szatkiewicz JP, Tropsha A, van den Oord EJ, Cascorbi I, Dettling M, Gazit E, Goff DC, Holden AL, Kelly DL, Malhotra AK, Nielsen J, Pirmohamed M, Rujescu D, Werge T, Levy DL, Josiassen RC, Kennedy JL, Lieberman JA, Daly MJ, Sullivan PF
Nature communications54757(2014 Sep)

Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.
Lino Cardenas CL, Renault N, Farce A, Cauffiez C, Allorge D, Lo-Guidice JM, Lhermitte M, Chavatte P, Broly F, Chevalier D
Gene487(1)10-20(2011 Nov)

Molecular modeling study on orphan human protein CYP4A22 for identification of potential ligand binding site.
Gajendrarao P, Krishnamoorthy N, Sakkiah S, Lazar P, Lee KW
Journal of molecular graphics & modelling28(6)524-32(2010 Feb)

Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population.
Hiratsuka M, Nozawa H, Katsumoto Y, Moteki T, Sasaki T, Konno Y, Mizugaki M
Mutation research599(1-2)98-104(2006 Jul)

Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.
Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH
Circulation111(1)63-9(2005 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that results could be helpful for further investigations of the potential role of CYP4A variants in the genetic susceptibility to cardiovascular diseases such as arterial hypertension.
Title: Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.

A homology model has been constructed for CYP4A22 and refined by molecular dynamics simulation.
Title: Molecular modeling study on orphan human protein CYP4A22 for identification of potential ligand binding site.

The following CYP4A22 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYP4A22 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18788	NM_001010969.4 Latest version!	Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu33353	NM_001308102.1 Latest version!	Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu33352	XM_005270767.3 Latest version!	Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu33355	XM_005270770.3 Latest version!	Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu18788	NM_001010969.3	Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CYP4A22 ( NM_001010969.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001010969.2 Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18788
Clone ID Related Accession (Same CDS sequence)	NM_001010969.4 , NM_001010969.3
Accession Version	NM_001010969.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1560bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	cytochrome P450 4A22 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC148248.1 and AL135960.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001010969.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AY280371.1, BC148248.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145122 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371891.8/ ENSP00000360958.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTGTCT CTGTCCTGAG CCCCAGCAGA CGCCTGGGTG GTGTCTCCGG GATCCTCCAA 
GTGACCTCCC TGCTCATTCT GCTTCTGCTG CTGATCAAGG CAGCTCAGCT CTACCTGCAT 
AGGCAGTGGC TGCTCAAAGC CCTCCAGCAG TTCCCGTGCC CTCCCTCCCA CTGGCTCTTC 
GGGCACATCC AGGAGTTCCA ACACGACCAG GAGCTACAAC GGATTCAGGA ACGGGTGAAG 
ACATTCCCAA GTGCCTGTCC TTATTGGATA TGGGGAGGCA AAGTTCGTGT CCAGCTCTAT 
GACCCTGACT ATATGAAGGT GATTCTGGGG AGATCAGACC CGAAATCCCA TGGATCCTAC 
AAATTCCTGG CTCCACGGAT TGGGTACGGC TTGCTCCTGT TGAATGGGCA GACATGGTTC 
CAGCATCGAC GGATGCTGAC CCCAGCCTTC CACAATGACA TCCTGAAGCC ATACGTGGGG 
CTCATGGCAG ACTCTGTACG AGTGATGCTG GACAAATGGG AAGAGCTCCT TGGCCAGGAT 
TCCCCTCTGG AGGTCTTTCA GCACGTCTCC TTGATGACCC TGGACACCAT CATGAAGAGT 
GCCTTCAGCC ATCAGGGCAG CATCCAGGTG GACAGGAATT CTCAGTCCTA CATCCAGGCC 
ATTAGTGACC TGAACAGCCT GGTTTTTTGC TGTATGAGGA ATGCCTTTCA TGAGAATGAC 
ACCATCTACA GCCTGACCTC TGCTGGCCGC TGGACACACC GCGCCTGCCA GCTGGCCCAT 
CAGCACACAG ACCAAGTGAT CCAACTGAGG AAGGCTCAAC TACAGAAGGA GGGGGAGCTG 
GAGAAGATCA AGAGGAAGAG GCACTTGGAT TTTCTGGACA TCCTCCTCTT GGCCAAAATG 
GAGAATGGGA GCATCTTGTC AGACAAGGAC CTCCGTGCTG AGGTGGACAC GTTCATGTTT 
GAGGGCCACG ACACCACAGC CAGTGGGATC TCCTGGATCC TCTATGCTCT GGCCACACAC 
CCCAAGCATC AGGAGAGGTG CCGGGAGGAG ATCCATGGCC TCCTGGGTGA TGGAGCCTCC 
ATCACCTGGA ACCACCTGGA CCAGATGCCC TACACCACCA TGTGCATTAA GGAGGCACTG 
AGGCTCTACC CACCGGTGCC AGGCATTGGA AGAGAGCTCA GCACTCCCGT CACCTTCCCT 
GATGGGCGCT CCTTGCCCAA AGGTATCATG GTCCTCCTCT CCATTTATGG CCTTCACCAC 
AACCCAAAAG TGTGGCCCAA CCTAGAGGTG TTTGACCCTT CCCGTTTTGC ACCGGGTTCT 
GCTCAACACA GCCACGCTTT CCTGCCCTTC TCAGGAGGAT CAAGGAACTG CATCGGGAAA 
CAATTTGCCA TGAACCAGCT GAAGGTGGCC AGGGCCCTGA CCCTGCTCCG CTTTGAGCTG 
CTGCCTGATC CCACCAGGAT CCCCATCCCC ATGGCACGAC TTGTGTTGAA ATCCAAAAAT 
GGAATCCACC TGCGTCTCAG GAGGCTCCCT AACCCTTGTG AAGACAAGGA CCAGCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001010969.2
CDS	46..1605
Translation	MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL

Target ORF information:

RefSeq Version	NM_001010969.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001010969.4

ORF Insert Sequence:

ATGAGTGTCT CTGTCCTGAG CCCCAGCAGA CGCCTGGGTG GTGTCTCCGG GATCCTCCAA 
GTGACCTCCC TGCTCATTCT GCTTCTGCTG CTGATCAAGG CAGCTCAGCT CTACCTGCAT 
AGGCAGTGGC TGCTCAAAGC CCTCCAGCAG TTCCCGTGCC CTCCCTCCCA CTGGCTCTTC 
GGGCACATCC AGGAGTTCCA ACACGACCAG GAGCTACAAC GGATTCAGGA ACGGGTGAAG 
ACATTCCCAA GTGCCTGTCC TTATTGGATA TGGGGAGGCA AAGTTCGTGT CCAGCTCTAT 
GACCCTGACT ATATGAAGGT GATTCTGGGG AGATCAGACC CGAAATCCCA TGGATCCTAC 
AAATTCCTGG CTCCACGGAT TGGGTACGGC TTGCTCCTGT TGAATGGGCA GACATGGTTC 
CAGCATCGAC GGATGCTGAC CCCAGCCTTC CACAATGACA TCCTGAAGCC ATACGTGGGG 
CTCATGGCAG ACTCTGTACG AGTGATGCTG GACAAATGGG AAGAGCTCCT TGGCCAGGAT 
TCCCCTCTGG AGGTCTTTCA GCACGTCTCC TTGATGACCC TGGACACCAT CATGAAGAGT 
GCCTTCAGCC ATCAGGGCAG CATCCAGGTG GACAGGAATT CTCAGTCCTA CATCCAGGCC 
ATTAGTGACC TGAACAGCCT GGTTTTTTGC TGTATGAGGA ATGCCTTTCA TGAGAATGAC 
ACCATCTACA GCCTGACCTC TGCTGGCCGC TGGACACACC GCGCCTGCCA GCTGGCCCAT 
CAGCACACAG ACCAAGTGAT CCAACTGAGG AAGGCTCAAC TACAGAAGGA GGGGGAGCTG 
GAGAAGATCA AGAGGAAGAG GCACTTGGAT TTTCTGGACA TCCTCCTCTT GGCCAAAATG 
GAGAATGGGA GCATCTTGTC AGACAAGGAC CTCCGTGCTG AGGTGGACAC GTTCATGTTT 
GAGGGCCACG ACACCACAGC CAGTGGGATC TCCTGGATCC TCTATGCTCT GGCCACACAC 
CCCAAGCATC AGGAGAGGTG CCGGGAGGAG ATCCATGGCC TCCTGGGTGA TGGAGCCTCC 
ATCACCTGGA ACCACCTGGA CCAGATGCCC TACACCACCA TGTGCATTAA GGAGGCACTG 
AGGCTCTACC CACCGGTGCC AGGCATTGGA AGAGAGCTCA GCACTCCCGT CACCTTCCCT 
GATGGGCGCT CCTTGCCCAA AGGTATCATG GTCCTCCTCT CCATTTATGG CCTTCACCAC 
AACCCAAAAG TGTGGCCCAA CCTAGAGGTG TTTGACCCTT CCCGTTTTGC ACCGGGTTCT 
GCTCAACACA GCCACGCTTT CCTGCCCTTC TCAGGAGGAT CAAGGAACTG CATCGGGAAA 
CAATTTGCCA TGAACCAGCT GAAGGTGGCC AGGGCCCTGA CCCTGCTCCG CTTTGAGCTG 
CTGCCTGATC CCACCAGGAT CCCCATCCCC ATGGCACGAC TTGTGTTGAA ATCCAAAAAT 
GGAATCCACC TGCGTCTCAG GAGGCTCCCT AACCCTTGTG AAGACAAGGA CCAGCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYP4A22 ( NM_001010969.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001010969.2 Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18788
Clone ID Related Accession (Same CDS sequence)	NM_001010969.4 , NM_001010969.3
Accession Version	NM_001010969.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1560bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-07-09
Organism	Homo sapiens(human)
Product	cytochrome P450 4A22 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC148248.1 and AL135960.1. This sequence is a reference standard in the RefSeqGene project. On Apr 22, 2015 this sequence version replaced NM_001010969.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AY280371.1, AY280372.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145122 [ECO:0000348] ##Evidence-Data-END##

ATGAGTGTCT CTGTCCTGAG CCCCAGCAGA CGCCTGGGTG GTGTCTCCGG GATCCTCCAA 
GTGACCTCCC TGCTCATTCT GCTTCTGCTG CTGATCAAGG CAGCTCAGCT CTACCTGCAT 
AGGCAGTGGC TGCTCAAAGC CCTCCAGCAG TTCCCGTGCC CTCCCTCCCA CTGGCTCTTC 
GGGCACATCC AGGAGTTCCA ACACGACCAG GAGCTACAAC GGATTCAGGA ACGGGTGAAG 
ACATTCCCAA GTGCCTGTCC TTATTGGATA TGGGGAGGCA AAGTTCGTGT CCAGCTCTAT 
GACCCTGACT ATATGAAGGT GATTCTGGGG AGATCAGACC CGAAATCCCA TGGATCCTAC 
AAATTCCTGG CTCCACGGAT TGGGTACGGC TTGCTCCTGT TGAATGGGCA GACATGGTTC 
CAGCATCGAC GGATGCTGAC CCCAGCCTTC CACAATGACA TCCTGAAGCC ATACGTGGGG 
CTCATGGCAG ACTCTGTACG AGTGATGCTG GACAAATGGG AAGAGCTCCT TGGCCAGGAT 
TCCCCTCTGG AGGTCTTTCA GCACGTCTCC TTGATGACCC TGGACACCAT CATGAAGAGT 
GCCTTCAGCC ATCAGGGCAG CATCCAGGTG GACAGGAATT CTCAGTCCTA CATCCAGGCC 
ATTAGTGACC TGAACAGCCT GGTTTTTTGC TGTATGAGGA ATGCCTTTCA TGAGAATGAC 
ACCATCTACA GCCTGACCTC TGCTGGCCGC TGGACACACC GCGCCTGCCA GCTGGCCCAT 
CAGCACACAG ACCAAGTGAT CCAACTGAGG AAGGCTCAAC TACAGAAGGA GGGGGAGCTG 
GAGAAGATCA AGAGGAAGAG GCACTTGGAT TTTCTGGACA TCCTCCTCTT GGCCAAAATG 
GAGAATGGGA GCATCTTGTC AGACAAGGAC CTCCGTGCTG AGGTGGACAC GTTCATGTTT 
GAGGGCCACG ACACCACAGC CAGTGGGATC TCCTGGATCC TCTATGCTCT GGCCACACAC 
CCCAAGCATC AGGAGAGGTG CCGGGAGGAG ATCCATGGCC TCCTGGGTGA TGGAGCCTCC 
ATCACCTGGA ACCACCTGGA CCAGATGCCC TACACCACCA TGTGCATTAA GGAGGCACTG 
AGGCTCTACC CACCGGTGCC AGGCATTGGA AGAGAGCTCA GCACTCCCGT CACCTTCCCT 
GATGGGCGCT CCTTGCCCAA AGGTATCATG GTCCTCCTCT CCATTTATGG CCTTCACCAC 
AACCCAAAAG TGTGGCCCAA CCTAGAGGTG TTTGACCCTT CCCGTTTTGC ACCGGGTTCT 
GCTCAACACA GCCACGCTTT CCTGCCCTTC TCAGGAGGAT CAAGGAACTG CATCGGGAAA 
CAATTTGCCA TGAACCAGCT GAAGGTGGCC AGGGCCCTGA CCCTGCTCCG CTTTGAGCTG 
CTGCCTGATC CCACCAGGAT CCCCATCCCC ATGGCACGAC TTGTGTTGAA ATCCAAAAAT 
GGAATCCACC TGCGTCTCAG GAGGCTCCCT AACCCTTGTG AAGACAAGGA CCAGCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001010969.2
CDS	62..1621
Translation	MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL

Target ORF information:

RefSeq Version	NM_001010969.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001010969.3

ORF Insert Sequence:

ATGAGTGTCT CTGTCCTGAG CCCCAGCAGA CGCCTGGGTG GTGTCTCCGG GATCCTCCAA 
GTGACCTCCC TGCTCATTCT GCTTCTGCTG CTGATCAAGG CAGCTCAGCT CTACCTGCAT 
AGGCAGTGGC TGCTCAAAGC CCTCCAGCAG TTCCCGTGCC CTCCCTCCCA CTGGCTCTTC 
GGGCACATCC AGGAGTTCCA ACACGACCAG GAGCTACAAC GGATTCAGGA ACGGGTGAAG 
ACATTCCCAA GTGCCTGTCC TTATTGGATA TGGGGAGGCA AAGTTCGTGT CCAGCTCTAT 
GACCCTGACT ATATGAAGGT GATTCTGGGG AGATCAGACC CGAAATCCCA TGGATCCTAC 
AAATTCCTGG CTCCACGGAT TGGGTACGGC TTGCTCCTGT TGAATGGGCA GACATGGTTC 
CAGCATCGAC GGATGCTGAC CCCAGCCTTC CACAATGACA TCCTGAAGCC ATACGTGGGG 
CTCATGGCAG ACTCTGTACG AGTGATGCTG GACAAATGGG AAGAGCTCCT TGGCCAGGAT 
TCCCCTCTGG AGGTCTTTCA GCACGTCTCC TTGATGACCC TGGACACCAT CATGAAGAGT 
GCCTTCAGCC ATCAGGGCAG CATCCAGGTG GACAGGAATT CTCAGTCCTA CATCCAGGCC 
ATTAGTGACC TGAACAGCCT GGTTTTTTGC TGTATGAGGA ATGCCTTTCA TGAGAATGAC 
ACCATCTACA GCCTGACCTC TGCTGGCCGC TGGACACACC GCGCCTGCCA GCTGGCCCAT 
CAGCACACAG ACCAAGTGAT CCAACTGAGG AAGGCTCAAC TACAGAAGGA GGGGGAGCTG 
GAGAAGATCA AGAGGAAGAG GCACTTGGAT TTTCTGGACA TCCTCCTCTT GGCCAAAATG 
GAGAATGGGA GCATCTTGTC AGACAAGGAC CTCCGTGCTG AGGTGGACAC GTTCATGTTT 
GAGGGCCACG ACACCACAGC CAGTGGGATC TCCTGGATCC TCTATGCTCT GGCCACACAC 
CCCAAGCATC AGGAGAGGTG CCGGGAGGAG ATCCATGGCC TCCTGGGTGA TGGAGCCTCC 
ATCACCTGGA ACCACCTGGA CCAGATGCCC TACACCACCA TGTGCATTAA GGAGGCACTG 
AGGCTCTACC CACCGGTGCC AGGCATTGGA AGAGAGCTCA GCACTCCCGT CACCTTCCCT 
GATGGGCGCT CCTTGCCCAA AGGTATCATG GTCCTCCTCT CCATTTATGG CCTTCACCAC 
AACCCAAAAG TGTGGCCCAA CCTAGAGGTG TTTGACCCTT CCCGTTTTGC ACCGGGTTCT 
GCTCAACACA GCCACGCTTT CCTGCCCTTC TCAGGAGGAT CAAGGAACTG CATCGGGAAA 
CAATTTGCCA TGAACCAGCT GAAGGTGGCC AGGGCCCTGA CCCTGCTCCG CTTTGAGCTG 
CTGCCTGATC CCACCAGGAT CCCCATCCCC ATGGCACGAC TTGTGTTGAA ATCCAAAAAT 
GGAATCCACC TGCGTCTCAG GAGGCTCCCT AACCCTTGTG AAGACAAGGA CCAGCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYP4A22 ( NM_001308102.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001295031.1 Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu33353
Clone ID Related Accession (Same CDS sequence)	NM_001308102.1
Accession Version	NM_001308102.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	cytochrome P450 4A22 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC148248.1, BC142690.1, AL135960.1 and BC142607.1. On Apr 22, 2015 this sequence version replaced XM_005270768.1. Transcript Variant: This variant (2) differs in the 3' UTR and has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct internal region and has a shorter C-terminus than isoform 1. ##Evidence-Data-START## Transcript exon combination :: BC142690.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145122 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGTCT CTGTCCTGAG CCCCAGCAGA CGCCTGGGTG GTGTCTCCGG GATCCTCCAA 
GTGACCTCCC TGCTCATTCT GCTTCTGCTG CTGATCAAGG CAGCTCAGCT CTACCTGCAT 
AGGCAGTGGC TGCTCAAAGC CCTCCAGCAG TTCCCGTGCC CTCCCTCCCA CTGGCTCTTC 
GGGCACATCC AGGAGTTCCA ACACGACCAG GAGCTACAAC GGATTCAGGA ACGGGTGAAG 
ACATTCCCAA GTGCCTGTCC TTATTGGATA TGGGGAGGCA AAGTTCGTGT CCAGCTCTAT 
GACCCTGACT ATATGAAGGT GATTCTGGGG AGATCAGACC CGAAATCCCA TGGATCCTAC 
AAATTCCTGG CTCCACGGAT TGGGTACGGC TTGCTCCTGT TGAATGGGCA GACATGGTTC 
CAGCATCGAC GGATGCTGAC CCCAGCCTTC CACAATGACA TCCTGAAGCC ATACGTGGGG 
CTCATGGCAG ACTCTGTACG AGTGATGCTG GACAAATGGG AAGAGCTCCT TGGCCAGGAT 
TCCCCTCTGG AGGTCTTTCA GCACGTCTCC TTGATGACCC TGGACACCAT CATGAAGAGT 
GCCTTCAGCC ATCAGGGCAG CATCCAGGTG GACAGACCAA GTGATCCAAC TGAGGAAGGC 
TCAACTACAG AAGGAGGGGG AGCTGGAGAA GATCAAGAGG AAGAGGCACT TGGATTTTCT 
GGACATCCTC CTCTTGGCCA AAGGGCCCCT GGTCTGCCCA GGCCTTGCTG GTGTTCAGGA 
TGGAATTGTT TCAGGAACCA CCTGGACCAG ATGCCCTACA CCACCATGTG CATTAAGGAG 
GCACTGAGGC TCTACCCACC GGTGCCAGGC ATTGGAAGAG AGCTCAGCAC TCCCGTCACC 
TTCCCTGATG GGCGCTCCTT GCCCAAAGGT ATCATGGTCC TCCTCTCCAT TTATGGCCTT 
CACCACAACC CAAAAGTGTG GCCCAACCTA GAGGTGTTTG ACCCTTCCCG TTTTGCACCG 
GGTTCTGCTC AACACAGCCA CGCTTTCCTG CCCTTCTCAG GAGGATCAAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001295031.1
CDS	62..1135
Translation	MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRPSDPTEEGSTTEGGGAGEDQEEEALGFSGHPPLGQRAPGLPRPCWCSGWNCFRNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSR

Target ORF information:

RefSeq Version	NM_001308102.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308102.1

ORF Insert Sequence:

ATGAGTGTCT CTGTCCTGAG CCCCAGCAGA CGCCTGGGTG GTGTCTCCGG GATCCTCCAA 
GTGACCTCCC TGCTCATTCT GCTTCTGCTG CTGATCAAGG CAGCTCAGCT CTACCTGCAT 
AGGCAGTGGC TGCTCAAAGC CCTCCAGCAG TTCCCGTGCC CTCCCTCCCA CTGGCTCTTC 
GGGCACATCC AGGAGTTCCA ACACGACCAG GAGCTACAAC GGATTCAGGA ACGGGTGAAG 
ACATTCCCAA GTGCCTGTCC TTATTGGATA TGGGGAGGCA AAGTTCGTGT CCAGCTCTAT 
GACCCTGACT ATATGAAGGT GATTCTGGGG AGATCAGACC CGAAATCCCA TGGATCCTAC 
AAATTCCTGG CTCCACGGAT TGGGTACGGC TTGCTCCTGT TGAATGGGCA GACATGGTTC 
CAGCATCGAC GGATGCTGAC CCCAGCCTTC CACAATGACA TCCTGAAGCC ATACGTGGGG 
CTCATGGCAG ACTCTGTACG AGTGATGCTG GACAAATGGG AAGAGCTCCT TGGCCAGGAT 
TCCCCTCTGG AGGTCTTTCA GCACGTCTCC TTGATGACCC TGGACACCAT CATGAAGAGT 
GCCTTCAGCC ATCAGGGCAG CATCCAGGTG GACAGACCAA GTGATCCAAC TGAGGAAGGC 
TCAACTACAG AAGGAGGGGG AGCTGGAGAA GATCAAGAGG AAGAGGCACT TGGATTTTCT 
GGACATCCTC CTCTTGGCCA AAGGGCCCCT GGTCTGCCCA GGCCTTGCTG GTGTTCAGGA 
TGGAATTGTT TCAGGAACCA CCTGGACCAG ATGCCCTACA CCACCATGTG CATTAAGGAG 
GCACTGAGGC TCTACCCACC GGTGCCAGGC ATTGGAAGAG AGCTCAGCAC TCCCGTCACC 
TTCCCTGATG GGCGCTCCTT GCCCAAAGGT ATCATGGTCC TCCTCTCCAT TTATGGCCTT 
CACCACAACC CAAAAGTGTG GCCCAACCTA GAGGTGTTTG ACCCTTCCCG TTTTGCACCG 
GGTTCTGCTC AACACAGCCA CGCTTTCCTG CCCTTCTCAG GAGGATCAAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYP4A22 ( XM_005270767.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005270824.1 Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu33352
Clone ID Related Accession (Same CDS sequence)	XM_005270767.3
Accession Version	XM_005270767.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cytochrome P450 4A22 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005270767.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTGTCT CTGTCCTGAG CCCCAGCAGA CGCCTGGGTG GTGTCTCCGG GATCCTCCAA 
GTGACCTCCC TGCTCATTCT GCTTCTGCTG CTGATCAAGG CAGCTCAGCT CTACCTGCAT 
AGGCAGTGGC TGCTCAAAGC CCTCCAGCAG TTCCCGTGCC CTCCCTCCCA CTGGCTCTTC 
GGGCACATCC AGGAGTTCCA ACACGACCAG GAGCTACAAC GGATTCAGGA ACGGGTGAAG 
ACATTCCCAA GTGCCTGTCC TTATTGGATA TGGGGAGGCA AAGTTCGTGT CCAGCTCTAT 
GACCCTGACT ATATGAAGGT GATTCTGGGG AGATCAGACC CGAAATCCCA TGGATCCTAC 
AAATTCCTGG CTCCACGGAT TGGGTACGGC TTGCTCCTGT TGAATGGGCA GACATGGTTC 
CAGCATCGAC GGATGCTGAC CCCAGCCTTC CACAATGACA TCCTGAAGCC ATACGTGGGG 
CTCATGGCAG ACTCTGTACG AGTGATGCTG GACAAATGGG AAGAGCTCCT TGGCCAGGAT 
TCCCCTCTGG AGGTCTTTCA GCACGTCTCC TTGATGACCC TGGACACCAT CATGAAGAGT 
GCCTTCAGCC ATCAGGGCAG CATCCAGGTG GACAGACCAA GTGATCCAAC TGAGGAAGGC 
TCAACTACAG AAGGAGGGGG AGCTGGAGAA GATCAAGAGG AAGAGGCACT TGGATTTTCT 
GGACATCCTC CTCTTGGCCA AAGGGCCCCT GGTCTGCCCA GGCCTTGCTG GTGTTCAGGA 
TGGAATTGTT TCAGGAACCA CCTGGACCAG ATGCCCTACA CCACCATGTG CATTAAGGAG 
GCACTGAGGC TCTACCCACC GGTGCCAGGC ATTGGAAGAG AGCTCAGCAC TCCCGTCACC 
TTCCCTGATG GGCGCTCCTT GCCCAAAGGT ATCATGGTCC TCCTCTCCAT TTATGGCCTT 
CACCACAACC CAAAAGTGTG GCCCAACCTA GAGGTGTTTG ACCCTTCCCG TTTTGCACCG 
GGTTCTGCTC AACACAGCCA CGCTTTCCTG CCCTTCTCAG GAGGATCAAG GAACTGCATC 
GGGAAACAAT TTGCCATGAA CCAGCTGAAG GTGGCCAGGG CCCTGACCCT GCTCCGCTTT 
GAGCTGCTGC CTGATCCCAC CAGGATCCCC ATCCCCATGG CACGACTTGT GTTGAAATCC 
AAAAATGGAA TCCACCTGCG TCTCAGGAGG CTCCCTAACC CTTGTGAAGA CAAGGACCAG 
CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005270824.1
CDS	44..1309
Translation	MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRPSDPTEEGSTTEGGGAGEDQEEEALGFSGHPPLGQRAPGLPRPCWCSGWNCFRNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL

Target ORF information:

RefSeq Version	XM_005270767.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005270767.3

ORF Insert Sequence:

ATGAGTGTCT CTGTCCTGAG CCCCAGCAGA CGCCTGGGTG GTGTCTCCGG GATCCTCCAA 
GTGACCTCCC TGCTCATTCT GCTTCTGCTG CTGATCAAGG CAGCTCAGCT CTACCTGCAT 
AGGCAGTGGC TGCTCAAAGC CCTCCAGCAG TTCCCGTGCC CTCCCTCCCA CTGGCTCTTC 
GGGCACATCC AGGAGTTCCA ACACGACCAG GAGCTACAAC GGATTCAGGA ACGGGTGAAG 
ACATTCCCAA GTGCCTGTCC TTATTGGATA TGGGGAGGCA AAGTTCGTGT CCAGCTCTAT 
GACCCTGACT ATATGAAGGT GATTCTGGGG AGATCAGACC CGAAATCCCA TGGATCCTAC 
AAATTCCTGG CTCCACGGAT TGGGTACGGC TTGCTCCTGT TGAATGGGCA GACATGGTTC 
CAGCATCGAC GGATGCTGAC CCCAGCCTTC CACAATGACA TCCTGAAGCC ATACGTGGGG 
CTCATGGCAG ACTCTGTACG AGTGATGCTG GACAAATGGG AAGAGCTCCT TGGCCAGGAT 
TCCCCTCTGG AGGTCTTTCA GCACGTCTCC TTGATGACCC TGGACACCAT CATGAAGAGT 
GCCTTCAGCC ATCAGGGCAG CATCCAGGTG GACAGACCAA GTGATCCAAC TGAGGAAGGC 
TCAACTACAG AAGGAGGGGG AGCTGGAGAA GATCAAGAGG AAGAGGCACT TGGATTTTCT 
GGACATCCTC CTCTTGGCCA AAGGGCCCCT GGTCTGCCCA GGCCTTGCTG GTGTTCAGGA 
TGGAATTGTT TCAGGAACCA CCTGGACCAG ATGCCCTACA CCACCATGTG CATTAAGGAG 
GCACTGAGGC TCTACCCACC GGTGCCAGGC ATTGGAAGAG AGCTCAGCAC TCCCGTCACC 
TTCCCTGATG GGCGCTCCTT GCCCAAAGGT ATCATGGTCC TCCTCTCCAT TTATGGCCTT 
CACCACAACC CAAAAGTGTG GCCCAACCTA GAGGTGTTTG ACCCTTCCCG TTTTGCACCG 
GGTTCTGCTC AACACAGCCA CGCTTTCCTG CCCTTCTCAG GAGGATCAAG GAACTGCATC 
GGGAAACAAT TTGCCATGAA CCAGCTGAAG GTGGCCAGGG CCCTGACCCT GCTCCGCTTT 
GAGCTGCTGC CTGATCCCAC CAGGATCCCC ATCCCCATGG CACGACTTGT GTTGAAATCC 
AAAAATGGAA TCCACCTGCG TCTCAGGAGG CTCCCTAACC CTTGTGAAGA CAAGGACCAG 
CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYP4A22 ( XM_005270770.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005270827.1 Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu33355
Clone ID Related Accession (Same CDS sequence)	XM_005270770.3
Accession Version	XM_005270770.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cytochrome P450 4A22 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005270770.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTGTCT CTGTCCTGAG CCCCAGCAGA CGCCTGGGTG GTGTCTCCGG GATCCTCCAA 
GTGACCTCCC TGCTCATTCT GCTTCTGCTG CTGATCAAGG CAGCTCAGCT CTACCTGCAT 
AGGCAGTGGC TGCTCAAAGC CCTCCAGCAG TTCCCGTGCC CTCCCTCCCA CTGGCTCTTC 
GGGCACATCC AGGAGTTCCA ACACGACCAG GAGCTACAAC GGATTCAGGA ACGGGTGAAG 
ACATTCCCAA GTGCCTGTCC TTATTGGATA TGGGGAGGCA AAGTTCGTGT CCAGCTCTAT 
GACCCTGACT ATATGAAGGT GATTCTGGGG AGATCAGACC CGAAATCCCA TGGATCCTAC 
AAATTCCTGG CTCCACGGAT TGGGTACGGC TTGCTCCTGT TGAATGGGCA GACATGGTTC 
CAGCATCGAC GGATGCTGAC CCCAGCCTTC CACAATGACA TCCTGAAGCC ATACGTGGGG 
CTCATGGCAG ACTCTGTACG AGTGATGCTG GACAAATGGG AAGAGCTCCT TGGCCAGGAT 
TCCCCTCTGG AGGTCTTTCA GCACGTCTCC TTGATGACCC TGGACACCAT CATGAAGAGT 
GCCTTCAGCC ATCAGGGCAG CATCCAGGTG GACAGACCAA GTGATCCAAC TGAGGAAGGC 
TCAACTACAG AAGGAGGGGG AGCTGGAGAA GATCAAGAGG AAGAGGCACT TGGATTTTCT 
GGACATCCTC CTCTTGGCCA AAATGGAGAA TGGGAGCATC TTGTCAGACA AGGACCTCCG 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005270827.1
CDS	44..829
Translation	MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRPSDPTEEGSTTEGGGAGEDQEEEALGFSGHPPLGQNGEWEHLVRQGPPC

Target ORF information:

RefSeq Version	XM_005270770.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005270770.3

ORF Insert Sequence:

ATGAGTGTCT CTGTCCTGAG CCCCAGCAGA CGCCTGGGTG GTGTCTCCGG GATCCTCCAA 
GTGACCTCCC TGCTCATTCT GCTTCTGCTG CTGATCAAGG CAGCTCAGCT CTACCTGCAT 
AGGCAGTGGC TGCTCAAAGC CCTCCAGCAG TTCCCGTGCC CTCCCTCCCA CTGGCTCTTC 
GGGCACATCC AGGAGTTCCA ACACGACCAG GAGCTACAAC GGATTCAGGA ACGGGTGAAG 
ACATTCCCAA GTGCCTGTCC TTATTGGATA TGGGGAGGCA AAGTTCGTGT CCAGCTCTAT 
GACCCTGACT ATATGAAGGT GATTCTGGGG AGATCAGACC CGAAATCCCA TGGATCCTAC 
AAATTCCTGG CTCCACGGAT TGGGTACGGC TTGCTCCTGT TGAATGGGCA GACATGGTTC 
CAGCATCGAC GGATGCTGAC CCCAGCCTTC CACAATGACA TCCTGAAGCC ATACGTGGGG 
CTCATGGCAG ACTCTGTACG AGTGATGCTG GACAAATGGG AAGAGCTCCT TGGCCAGGAT 
TCCCCTCTGG AGGTCTTTCA GCACGTCTCC TTGATGACCC TGGACACCAT CATGAAGAGT 
GCCTTCAGCC ATCAGGGCAG CATCCAGGTG GACAGACCAA GTGATCCAAC TGAGGAAGGC 
TCAACTACAG AAGGAGGGGG AGCTGGAGAA GATCAAGAGG AAGAGGCACT TGGATTTTCT 
GGACATCCTC CTCTTGGCCA AAATGGAGAA TGGGAGCATC TTGTCAGACA AGGACCTCCG 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
Nature communications54757(2014 Sep)
Goldstein JI,Jarskog LF,Hilliard C,Alfirevic A,Duncan L,Fourches D,Huang H,Lek M,Neale BM,Ripke S,Shianna K,Szatkiewicz JP,Tropsha A,van den Oord EJ,Cascorbi I,Dettling M,Gazit E,Goff DC,Holden AL,Kelly DL,Malhotra AK,Nielsen J,Pirmohamed M,Rujescu D,Werge T,Levy DL,Josiassen RC,Kennedy JL,Lieberman JA,Daly MJ,Sullivan PF

Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.
Gene487(1)10-20(2011 Nov)
Lino Cardenas CL,Renault N,Farce A,Cauffiez C,Allorge D,Lo-Guidice JM,Lhermitte M,Chavatte P,Broly F,Chevalier D

Molecular modeling study on orphan human protein CYP4A22 for identification of potential ligand binding site.
Journal of molecular graphics & modelling28(6)524-32(2010 Feb)
Gajendrarao P,Krishnamoorthy N,Sakkiah S,Lazar P,Lee KW

Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population.
Mutation research599(1-2)98-104(2006 Jul)
Hiratsuka M,Nozawa H,Katsumoto Y,Moteki T,Sasaki T,Konno Y,Mizugaki M

Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.
Circulation111(1)63-9(2005 Jan)
Gainer JV,Bellamine A,Dawson EP,Womble KE,Grant SW,Wang Y,Cupples LA,Guo CY,Demissie S,O'Donnell CJ,Brown NJ,Waterman MR,Capdevila JH

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CYP4A22 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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