CXCL17 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CXCL17
Entrez Gene ID	284340
Full Name	C-X-C motif chemokine ligand 17
Synonyms	DMC,Dcip1,UNQ473,VCC-1,VCC1
General protein information	Preferred Names C-X-C motif chemokine ligand 17 Names C-X-C motif chemokine 17 6-Cys CXCL17 VEGF co-regulated chemokine 1 VEGF coregulated chemokine 1 chemokine (C-X-C motif) ligand 17 dendritic cell and monocyte chemokine-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.2
Summary	The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015].
Disorder MIM:	611387

mRNA and Protein(s)

mRNA	Protein	Name
NM_198477.3	NP_940879.1	C-X-C motif chemokine 17 precursor
NM_198477.1	NP_940879.1	VEGF coregulated chemokine 1 precursor
NM_198477.2	NP_940879.1	C-X-C motif chemokine 17 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CXCL17	NP_940879.1
Rattus norvegicus (Norway rat)	Cxcl17	NP_001100961.1
Bos taurus (cattle)	CXCL17	NP_001077268.1
Mus musculus (house mouse)	Cxcl17	NP_705804.2
Pan troglodytes (chimpanzee)	CXCL17	XP_001154726.1
	CXCL17	XP_001105835.1

Gene Ontology
Bibliography

Related articles in PubMed

The role and clinical significance of the CXCL17-CXCR8 (GPR35) axis in breast cancer.
Guo YJ, Zhou YJ, Yang XL, Shao ZM, Ou ZL
Biochemical and biophysical research communications493(3)1159-1167(2017 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High expression of CXCL17 correlates with shorter overall survival of breast cancer patients.CXCL17 interacts with CXCR8 in breast cancer cells.
Title: The role and clinical significance of the CXCL17-CXCR8 (GPR35) axis in breast cancer.

CXCL17 attenuates Imiquimod -induced psoriasis-like skin inflammation by recruiting myeloid-derived suppressor cells and regulatory T cells , which may be important for regulating excessive inflammation in psoriasis skin.
Title: CXCL17 Attenuates Imiquimod-Induced Psoriasis-like Skin Inflammation by Recruiting Myeloid-Derived Suppressor Cells and Regulatory T Cells.

This article shows that GPR35 is the receptor of CXCL17.
Title: Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17.

CXCL17 production correlated with adverse immune infiltration and might be an important target for anti-HCC therapies.
Title: CXCL17 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma.

We conclude that CXCL17 is an antimicrobial mucosal chemokine that may play a role in the pathogenesis of interstitial lung diseases
Title: CXCL17 is a mucosal chemokine elevated in idiopathic pulmonary fibrosis that exhibits broad antimicrobial activity.

The following CXCL17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCL17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02580	NM_198477.3 Latest version!	Homo sapiens C-X-C motif chemokine ligand 17 (CXCL17), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu02580	NM_198477.1	Homo sapiens chemokine (C-X-C motif) ligand 17 (CXCL17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu02580	NM_198477.2	Homo sapiens C-X-C motif chemokine ligand 17 (CXCL17), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CXCL17 ( NM_198477.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_940879.1 Homo sapiens C-X-C motif chemokine ligand 17 (CXCL17), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02580
Clone ID Related Accession (Same CDS sequence)	NM_198477.3 , NM_198477.1 , NM_198477.2
Accession Version	NM_198477.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	C-X-C motif chemokine 17 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY358433.1, BU684368.1 and AC011497.6. On May 17, 2019 this sequence version replaced NM_198477.2. Transcript Variant: This variant (1) represents the protein-coding transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292985.1, DB236758.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2147920 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000601181.6/ ENSP00000472467.1 Protein has antimicrobial activity :: PMID: 22611239 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAAGTTC TAATCTCTTC CCTCCTCCTG TTGCTGCCAC TAATGCTGAT GTCCATGGTC 
TCTAGCAGCC TGAATCCAGG GGTCGCCAGA GGCCACAGGG ACCGAGGCCA GGCTTCTAGG 
AGATGGCTCC AGGAAGGCGG CCAAGAATGT GAGTGCAAAG ATTGGTTCCT GAGAGCCCCG 
AGAAGAAAAT TCATGACAGT GTCTGGGCTG CCAAAGAAGC AGTGCCCCTG TGATCATTTC 
AAGGGCAATG TGAAGAAAAC AAGACACCAA AGGCACCACA GAAAGCCAAA CAAGCATTCC 
AGAGCCTGCC AGCAATTTCT CAAACAATGT CAGCTAAGAA GCTTTGCTCT GCCTTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_940879.1
CDS	115..474
Translation	MKVLISSLLLLLPLMLMSMVSSSLNPGVARGHRDRGQASRRWLQEGGQECECKDWFLRAPRRKFMTVSGLPKKQCPCDHFKGNVKKTRHQRHHRKPNKHSRACQQFLKQCQLRSFALPL

Target ORF information:

RefSeq Version	NM_198477.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-X-C motif chemokine ligand 17 (CXCL17), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198477.3

ORF Insert Sequence:

ATGAAAGTTC TAATCTCTTC CCTCCTCCTG TTGCTGCCAC TAATGCTGAT GTCCATGGTC 
TCTAGCAGCC TGAATCCAGG GGTCGCCAGA GGCCACAGGG ACCGAGGCCA GGCTTCTAGG 
AGATGGCTCC AGGAAGGCGG CCAAGAATGT GAGTGCAAAG ATTGGTTCCT GAGAGCCCCG 
AGAAGAAAAT TCATGACAGT GTCTGGGCTG CCAAAGAAGC AGTGCCCCTG TGATCATTTC 
AAGGGCAATG TGAAGAAAAC AAGACACCAA AGGCACCACA GAAAGCCAAA CAAGCATTCC 
AGAGCCTGCC AGCAATTTCT CAAACAATGT CAGCTAAGAA GCTTTGCTCT GCCTTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CXCL17 ( NM_198477.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_940879.1 Homo sapiens chemokine (C-X-C motif) ligand 17 (CXCL17), mRNA.

Price & Availability↑

CloneID	OHu02580
Clone ID Related Accession (Same CDS sequence)	NM_198477.3 , NM_198477.1 , NM_198477.2
Accession Version	NM_198477.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	VEGF coregulated chemokine 1 precursor
Comment

ATGAAAGTTC TAATCTCTTC CCTCCTCCTG TTGCTGCCAC TAATGCTGAT GTCCATGGTC 
TCTAGCAGCC TGAATCCAGG GGTCGCCAGA GGCCACAGGG ACCGAGGCCA GGCTTCTAGG 
AGATGGCTCC AGGAAGGCGG CCAAGAATGT GAGTGCAAAG ATTGGTTCCT GAGAGCCCCG 
AGAAGAAAAT TCATGACAGT GTCTGGGCTG CCAAAGAAGC AGTGCCCCTG TGATCATTTC 
AAGGGCAATG TGAAGAAAAC AAGACACCAA AGGCACCACA GAAAGCCAAA CAAGCATTCC 
AGAGCCTGCC AGCAATTTCT CAAACAATGT CAGCTAAGAA GCTTTGCTCT GCCTTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_940879.1
Translation	MKVLISSLLLLLPLMLMSMVSSSLNPGVARGHRDRGQASRRWLQEGGQECECKDWFLRAPRRKFMTVSGLPKKQCPCDHFKGNVKKTRHQRHHRKPNKHSRACQQFLKQCQLRSFALPL

Target ORF information:

RefSeq Version	NM_198477.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens chemokine (C-X-C motif) ligand 17 (CXCL17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198477.1

ORF Insert Sequence:

ATGAAAGTTC TAATCTCTTC CCTCCTCCTG TTGCTGCCAC TAATGCTGAT GTCCATGGTC 
TCTAGCAGCC TGAATCCAGG GGTCGCCAGA GGCCACAGGG ACCGAGGCCA GGCTTCTAGG 
AGATGGCTCC AGGAAGGCGG CCAAGAATGT GAGTGCAAAG ATTGGTTCCT GAGAGCCCCG 
AGAAGAAAAT TCATGACAGT GTCTGGGCTG CCAAAGAAGC AGTGCCCCTG TGATCATTTC 
AAGGGCAATG TGAAGAAAAC AAGACACCAA AGGCACCACA GAAAGCCAAA CAAGCATTCC 
AGAGCCTGCC AGCAATTTCT CAAACAATGT CAGCTAAGAA GCTTTGCTCT GCCTTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CXCL17 ( NM_198477.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_940879.1 Homo sapiens C-X-C motif chemokine ligand 17 (CXCL17), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02580
Clone ID Related Accession (Same CDS sequence)	NM_198477.3 , NM_198477.1 , NM_198477.2
Accession Version	NM_198477.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	C-X-C motif chemokine 17 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY598464.1, AY358433.1 and BU684368.1. On Dec 8, 2015 this sequence version replaced NM_198477.1. Transcript Variant: This variant (1) represents the protein-coding transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY598464.1, AY358433.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2147920 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 22611239 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAAGTTC TAATCTCTTC CCTCCTCCTG TTGCTGCCAC TAATGCTGAT GTCCATGGTC 
TCTAGCAGCC TGAATCCAGG GGTCGCCAGA GGCCACAGGG ACCGAGGCCA GGCTTCTAGG 
AGATGGCTCC AGGAAGGCGG CCAAGAATGT GAGTGCAAAG ATTGGTTCCT GAGAGCCCCG 
AGAAGAAAAT TCATGACAGT GTCTGGGCTG CCAAAGAAGC AGTGCCCCTG TGATCATTTC 
AAGGGCAATG TGAAGAAAAC AAGACACCAA AGGCACCACA GAAAGCCAAA CAAGCATTCC 
AGAGCCTGCC AGCAATTTCT CAAACAATGT CAGCTAAGAA GCTTTGCTCT GCCTTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_940879.1
CDS	217..576
Translation	MKVLISSLLLLLPLMLMSMVSSSLNPGVARGHRDRGQASRRWLQEGGQECECKDWFLRAPRRKFMTVSGLPKKQCPCDHFKGNVKKTRHQRHHRKPNKHSRACQQFLKQCQLRSFALPL

Target ORF information:

RefSeq Version	NM_198477.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-X-C motif chemokine ligand 17 (CXCL17), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198477.2

ORF Insert Sequence:

ATGAAAGTTC TAATCTCTTC CCTCCTCCTG TTGCTGCCAC TAATGCTGAT GTCCATGGTC 
TCTAGCAGCC TGAATCCAGG GGTCGCCAGA GGCCACAGGG ACCGAGGCCA GGCTTCTAGG 
AGATGGCTCC AGGAAGGCGG CCAAGAATGT GAGTGCAAAG ATTGGTTCCT GAGAGCCCCG 
AGAAGAAAAT TCATGACAGT GTCTGGGCTG CCAAAGAAGC AGTGCCCCTG TGATCATTTC 
AAGGGCAATG TGAAGAAAAC AAGACACCAA AGGCACCACA GAAAGCCAAA CAAGCATTCC 
AGAGCCTGCC AGCAATTTCT CAAACAATGT CAGCTAAGAA GCTTTGCTCT GCCTTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role and clinical significance of the CXCL17-CXCR8 (GPR35) axis in breast cancer.
Biochemical and biophysical research communications493(3)1159-1167(2017 11)
Guo YJ,Zhou YJ,Yang XL,Shao ZM,Ou ZL

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CXCL17 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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