KCNRG cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNRG
Entrez Gene ID	283518
Full Name	potassium channel regulator
Synonyms	DLTET
General protein information	Preferred Names potassium channel regulator Names potassium channel regulatory protein putative potassium channel regulatory protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q14.2
Summary	This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].
Disorder MIM:	607947

mRNA and Protein(s)

mRNA	Protein	Name
NM_199464.3	NP_955751.1	potassium channel regulatory protein isoform 2
NM_199464.2	NP_955751.1	potassium channel regulatory protein isoform 2
NM_173605.1	NP_775876.1	potassium channel regulatory protein isoform 1
NM_173605.2	NP_775876.1	potassium channel regulatory protein isoform 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	KCNRG	NP_991377.1
Gallus gallus (chicken)	KCNRG	XP_417068.2
Xenopus tropicalis (tropical clawed frog)	kcnrg	NP_988863.1
Homo sapiens (human)	KCNRG	NP_775876.1
	LOC707341	XP_002808193.1
Canis lupus familiaris (dog)	KCNRG	XP_849751.1
Mus musculus (house mouse)	Kcnrg	NP_001034194.1
Rattus norvegicus (Norway rat)	Kcnrg	NP_001178616.1
Pan troglodytes (chimpanzee)	KCNRG	XP_522758.2

Gene Ontology
Bibliography

Related articles in PubMed

Pro-apoptotic and antiproliferative activity of human KCNRG, a putative tumor suppressor in 13q14 region.
Birerdinc A, Nohelty E, Marakhonov A, Manyam G, Panov I, Coon S, Nikitin E, Skoblov M, Chandhoke V, Baranova A
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine31(1)33-45(2010 Jan)

Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels.
Usman H, Mathew MK
Biochemical and biophysical research communications391(3)1301-5(2010 Jan)

Shifted Transversal Design smart-pooling for high coverage interactome mapping.
Xin X, Rual JF, Hirozane-Kishikawa T, Hill DE, Vidal M, Boone C, Thierry-Mieg N
Genome research19(7)1262-9(2009 Jul)

Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigen.
Alimohammadi M, Dubois N, Sk?ldberg F, Hallgren A, Tardivel I, Hedstrand H, Haavik J, Husebye ES, Gustafsson J, Rorsman F, Meloni A, Janson C, Vialettes B, Kajosaari M, Egner W, Sargur R, Pont?n F, Amoura Z, Grimfeld A, De Luca F, Betterle C, Perheentupa J, K?mpe O, Carel JC
Proceedings of the National Academy of Sciences of the United States of America106(11)4396-401(2009 Mar)

Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas.
Cho YG, Kim CJ, Song JH, Rhie DJ, Park YK, Kim SY, Nam SW, Yoo NJ, Lee JY, Park WS
Experimental & molecular medicine38(3)247-55(2006 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The haploinsufficiency of KCNRG might be relevant to the progression of chronic lymphocytic leukemia (CLL)and multiple myeloma(MM) at least in a subset of patients.
Title: Pro-apoptotic and antiproliferative activity of human KCNRG, a putative tumor suppressor in 13q14 region.

KCNRG is an ER-associated protein, which is proposed to regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.
Title: Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels.

Autoantibodies to KCNRG were present in 7 of the 8 patients with respiratory symptoms in autoimmune polyendocrine syndrome type 1
Title: Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigen.

Results suggest that genetic alterations and the expression of KCNRG might play an important role in the development and/or progression of a subset of hepatocellular carcinoma.
Title: Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas.

the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3; is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene
Title: A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3.

The following KCNRG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNRG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07329	NM_173605.2 Latest version!	Homo sapiens potassium channel regulator (KCNRG), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu02828	NM_199464.3 Latest version!	Homo sapiens potassium channel regulator (KCNRG), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu02828	NM_199464.2	Homo sapiens potassium channel regulator (KCNRG), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu07329	NM_173605.1	Homo sapiens potassium channel regulator (KCNRG), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNRG ( NM_173605.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_775876.1 Homo sapiens potassium channel regulator (KCNRG), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07329
Clone ID Related Accession (Same CDS sequence)	NM_173605.1 , NM_173605.2
Accession Version	NM_173605.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 819bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	potassium channel regulatory protein isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY169388.1. Transcript Variant: This variant (1) is the shorter transcript and encodes the longer protein (isoform 1). ##Evidence-Data-START## Transcript exon combination :: AY169388.1, AY190921.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END##

ATGAGTAGTC AGGAACTGGT CACTTTGAAT GTGGGAGGGA AGATATTCAC GACAAGGTTT 
TCTACGATAA AGCAGTTTCC TGCTTCTCGT TTGGCACGCA TGTTAGATGG CAGAGACCAA 
GAATTCAAGA TGGTTGGTGG CCAGATTTTT GTAGACAGAG ATGGTGATTT GTTTAGTTTC 
ATCTTAGATT TTTTGAGAAC TCACCAGCTT TTATTACCCA CTGAATTTTC AGACTATCTT 
AGGCTTCAGA GAGAGGCTCT TTTCTATGAA CTTCGTTCTC TAGTTGATCT CTTAAACCCA 
TACCTGCTAC AGCCAAGACC TGCTCTTGTG GAGGTACATT TCCTAAGCCG GAACACTCAA 
GCTTTTTTCA GGGTGTTTGG CTCTTGCAGC AAAACAATTG AGATGCTAAC AGGGAGGATT 
ACAGTGTTTA CAGAACAACC TTCAGCGCCG ACCTGGAATG GTAACTTTTT CCCTCCTCAG 
ATGACCTTAC TTCCACTGCC TCCACAAAGA CCTTCTTACC ATGACCTGGT TTTCCAGTGT 
GGTTCTGACA GCACTACTGA TAACCAAACT GGAGTCAGGT ATGTTTCTAT AAAACCTGAT 
AACCGAAAAT TGGCCAACGG AACAAATGTC CTCGGCTTAC TGATTGACAC TTTATTAAAG 
GAAGGCTTTC ATTTGGTCAG CACTAGAACA GTATCTTCTG AAGACAAAAC TGAATGCTAT 
AGCTTTGAAA GGATAAAAAG CCCTGAAGTG CTCATCACGA ATGAAACACC AAAACCAGAG 
ACTATCATCA TACCAGAGCA ATCTCAGATA AAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775876.1
CDS	241..1059
Translation	MSSQELVTLNVGGKIFTTRFSTIKQFPASRLARMLDGRDQEFKMVGGQIFVDRDGDLFSFILDFLRTHQLLLPTEFSDYLRLQREALFYELRSLVDLLNPYLLQPRPALVEVHFLSRNTQAFFRVFGSCSKTIEMLTGRITVFTEQPSAPTWNGNFFPPQMTLLPLPPQRPSYHDLVFQCGSDSTTDNQTGVRYVSIKPDNRKLANGTNVLGLLIDTLLKEGFHLVSTRTVSSEDKTECYSFERIKSPEVLITNETPKPETIIIPEQSQIKK

Target ORF information:

RefSeq Version	NM_173605.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium channel regulator (KCNRG), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173605.1

ORF Insert Sequence:

ATGAGTAGTC AGGAACTGGT CACTTTGAAT GTGGGAGGGA AGATATTCAC GACAAGGTTT 
TCTACGATAA AGCAGTTTCC TGCTTCTCGT TTGGCACGCA TGTTAGATGG CAGAGACCAA 
GAATTCAAGA TGGTTGGTGG CCAGATTTTT GTAGACAGAG ATGGTGATTT GTTTAGTTTC 
ATCTTAGATT TTTTGAGAAC TCACCAGCTT TTATTACCCA CTGAATTTTC AGACTATCTT 
AGGCTTCAGA GAGAGGCTCT TTTCTATGAA CTTCGTTCTC TAGTTGATCT CTTAAACCCA 
TACCTGCTAC AGCCAAGACC TGCTCTTGTG GAGGTACATT TCCTAAGCCG GAACACTCAA 
GCTTTTTTCA GGGTGTTTGG CTCTTGCAGC AAAACAATTG AGATGCTAAC AGGGAGGATT 
ACAGTGTTTA CAGAACAACC TTCAGCGCCG ACCTGGAATG GTAACTTTTT CCCTCCTCAG 
ATGACCTTAC TTCCACTGCC TCCACAAAGA CCTTCTTACC ATGACCTGGT TTTCCAGTGT 
GGTTCTGACA GCACTACTGA TAACCAAACT GGAGTCAGGT ATGTTTCTAT AAAACCTGAT 
AACCGAAAAT TGGCCAACGG AACAAATGTC CTCGGCTTAC TGATTGACAC TTTATTAAAG 
GAAGGCTTTC ATTTGGTCAG CACTAGAACA GTATCTTCTG AAGACAAAAC TGAATGCTAT 
AGCTTTGAAA GGATAAAAAG CCCTGAAGTG CTCATCACGA ATGAAACACC AAAACCAGAG 
ACTATCATCA TACCAGAGCA ATCTCAGATA AAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNRG ( NM_173605.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_775876.1 Homo sapiens potassium channel regulator (KCNRG), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07329
Clone ID Related Accession (Same CDS sequence)	NM_173605.1 , NM_173605.2
Accession Version	NM_173605.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 819bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	potassium channel regulatory protein isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY169388.1. On Nov 23, 2018 this sequence version replaced NM_173605.1. Transcript Variant: This variant (1) is the shorter transcript and encodes the longer protein (isoform 1). ##Evidence-Data-START## Transcript exon combination :: AY129654.1, AY169388.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000312942.2/ ENSP00000324191.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTAGTC AGGAACTGGT CACTTTGAAT GTGGGAGGGA AGATATTCAC GACAAGGTTT 
TCTACGATAA AGCAGTTTCC TGCTTCTCGT TTGGCACGCA TGTTAGATGG CAGAGACCAA 
GAATTCAAGA TGGTTGGTGG CCAGATTTTT GTAGACAGAG ATGGTGATTT GTTTAGTTTC 
ATCTTAGATT TTTTGAGAAC TCACCAGCTT TTATTACCCA CTGAATTTTC AGACTATCTT 
AGGCTTCAGA GAGAGGCTCT TTTCTATGAA CTTCGTTCTC TAGTTGATCT CTTAAACCCA 
TACCTGCTAC AGCCAAGACC TGCTCTTGTG GAGGTACATT TCCTAAGCCG GAACACTCAA 
GCTTTTTTCA GGGTGTTTGG CTCTTGCAGC AAAACAATTG AGATGCTAAC AGGGAGGATT 
ACAGTGTTTA CAGAACAACC TTCAGCGCCG ACCTGGAATG GTAACTTTTT CCCTCCTCAG 
ATGACCTTAC TTCCACTGCC TCCACAAAGA CCTTCTTACC ATGACCTGGT TTTCCAGTGT 
GGTTCTGACA GCACTACTGA TAACCAAACT GGAGTCAGGT ATGTTTCTAT AAAACCTGAT 
AACCGAAAAT TGGCCAACGG AACAAATGTC CTCGGCTTAC TGATTGACAC TTTATTAAAG 
GAAGGCTTTC ATTTGGTCAG CACTAGAACA GTATCTTCTG AAGACAAAAC TGAATGCTAT 
AGCTTTGAAA GGATAAAAAG CCCTGAAGTG CTCATCACGA ATGAAACACC AAAACCAGAG 
ACTATCATCA TACCAGAGCA ATCTCAGATA AAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775876.1
CDS	51..869
Translation	MSSQELVTLNVGGKIFTTRFSTIKQFPASRLARMLDGRDQEFKMVGGQIFVDRDGDLFSFILDFLRTHQLLLPTEFSDYLRLQREALFYELRSLVDLLNPYLLQPRPALVEVHFLSRNTQAFFRVFGSCSKTIEMLTGRITVFTEQPSAPTWNGNFFPPQMTLLPLPPQRPSYHDLVFQCGSDSTTDNQTGVRYVSIKPDNRKLANGTNVLGLLIDTLLKEGFHLVSTRTVSSEDKTECYSFERIKSPEVLITNETPKPETIIIPEQSQIKK

Target ORF information:

RefSeq Version	NM_173605.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium channel regulator (KCNRG), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173605.2

ORF Insert Sequence:

ATGAGTAGTC AGGAACTGGT CACTTTGAAT GTGGGAGGGA AGATATTCAC GACAAGGTTT 
TCTACGATAA AGCAGTTTCC TGCTTCTCGT TTGGCACGCA TGTTAGATGG CAGAGACCAA 
GAATTCAAGA TGGTTGGTGG CCAGATTTTT GTAGACAGAG ATGGTGATTT GTTTAGTTTC 
ATCTTAGATT TTTTGAGAAC TCACCAGCTT TTATTACCCA CTGAATTTTC AGACTATCTT 
AGGCTTCAGA GAGAGGCTCT TTTCTATGAA CTTCGTTCTC TAGTTGATCT CTTAAACCCA 
TACCTGCTAC AGCCAAGACC TGCTCTTGTG GAGGTACATT TCCTAAGCCG GAACACTCAA 
GCTTTTTTCA GGGTGTTTGG CTCTTGCAGC AAAACAATTG AGATGCTAAC AGGGAGGATT 
ACAGTGTTTA CAGAACAACC TTCAGCGCCG ACCTGGAATG GTAACTTTTT CCCTCCTCAG 
ATGACCTTAC TTCCACTGCC TCCACAAAGA CCTTCTTACC ATGACCTGGT TTTCCAGTGT 
GGTTCTGACA GCACTACTGA TAACCAAACT GGAGTCAGGT ATGTTTCTAT AAAACCTGAT 
AACCGAAAAT TGGCCAACGG AACAAATGTC CTCGGCTTAC TGATTGACAC TTTATTAAAG 
GAAGGCTTTC ATTTGGTCAG CACTAGAACA GTATCTTCTG AAGACAAAAC TGAATGCTAT 
AGCTTTGAAA GGATAAAAAG CCCTGAAGTG CTCATCACGA ATGAAACACC AAAACCAGAG 
ACTATCATCA TACCAGAGCA ATCTCAGATA AAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNRG ( NM_199464.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_955751.1 Homo sapiens potassium channel regulator (KCNRG), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02828
Clone ID Related Accession (Same CDS sequence)	NM_199464.3 , NM_199464.2
Accession Version	NM_199464.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	potassium channel regulatory protein isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY169387.1 and BX116021.1. On May 31, 2019 this sequence version replaced NM_199464.2. Transcript Variant: This variant (2) contains an alternate exon which results in a frameshift compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AY129653.1, BC020887.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144333, SAMEA2156099 [ECO:0000348] ##Evidence-Data-END##

ATGAGTAGTC AGGAACTGGT CACTTTGAAT GTGGGAGGGA AGATATTCAC GACAAGGTTT 
TCTACGATAA AGCAGTTTCC TGCTTCTCGT TTGGCACGCA TGTTAGATGG CAGAGACCAA 
GAATTCAAGA TGGTTGGTGG CCAGATTTTT GTAGACAGAG ATGGTGATTT GTTTAGTTTC 
ATCTTAGATT TTTTGAGAAC TCACCAGCTT TTATTACCCA CTGAATTTTC AGACTATCTT 
AGGCTTCAGA GAGAGGCTCT TTTCTATGAA CTTCGTTCTC TAGTTGATCT CTTAAACCCA 
TACCTGCTAC AGCCAAGACC TGCTCTTGTG GAGGTACATT TCCTAAGCCG GAACACTCAA 
GCTTTTTTCA GGGTGTTTGG CTCTTGCAGC AAAACAATTG AGATGCTAAC AGGGAGGATT 
ACAGTGTTTA CAGAACAACC TTCAGCGCCG ACCTGGAATG GTAACTTTTT CCCTCCTCAG 
ATGACCTTAC TTCCACTGCC TCCACAAAGA CCTTCTTACC ATGACCTGGT TTTCCAGTGT 
GGTTCTGACA GCACTACTGA TAACCAAACT GGAGTCAGGC TGGTATGCAA TGGCGTGATC 
TCGGCTCACC ACAACCTCCG CCTCTGGGGT TCAAGTGATT CTCCTGCCTC AGCCTCCCGA 
GTAGCTGGGA TTACAGGTAT GTTTCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_955751.1
CDS	51..740
Translation	MSSQELVTLNVGGKIFTTRFSTIKQFPASRLARMLDGRDQEFKMVGGQIFVDRDGDLFSFILDFLRTHQLLLPTEFSDYLRLQREALFYELRSLVDLLNPYLLQPRPALVEVHFLSRNTQAFFRVFGSCSKTIEMLTGRITVFTEQPSAPTWNGNFFPPQMTLLPLPPQRPSYHDLVFQCGSDSTTDNQTGVRLVCNGVISAHHNLRLWGSSDSPASASRVAGITGMFL

Target ORF information:

RefSeq Version	NM_199464.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium channel regulator (KCNRG), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199464.3

ORF Insert Sequence:

ATGAGTAGTC AGGAACTGGT CACTTTGAAT GTGGGAGGGA AGATATTCAC GACAAGGTTT 
TCTACGATAA AGCAGTTTCC TGCTTCTCGT TTGGCACGCA TGTTAGATGG CAGAGACCAA 
GAATTCAAGA TGGTTGGTGG CCAGATTTTT GTAGACAGAG ATGGTGATTT GTTTAGTTTC 
ATCTTAGATT TTTTGAGAAC TCACCAGCTT TTATTACCCA CTGAATTTTC AGACTATCTT 
AGGCTTCAGA GAGAGGCTCT TTTCTATGAA CTTCGTTCTC TAGTTGATCT CTTAAACCCA 
TACCTGCTAC AGCCAAGACC TGCTCTTGTG GAGGTACATT TCCTAAGCCG GAACACTCAA 
GCTTTTTTCA GGGTGTTTGG CTCTTGCAGC AAAACAATTG AGATGCTAAC AGGGAGGATT 
ACAGTGTTTA CAGAACAACC TTCAGCGCCG ACCTGGAATG GTAACTTTTT CCCTCCTCAG 
ATGACCTTAC TTCCACTGCC TCCACAAAGA CCTTCTTACC ATGACCTGGT TTTCCAGTGT 
GGTTCTGACA GCACTACTGA TAACCAAACT GGAGTCAGGC TGGTATGCAA TGGCGTGATC 
TCGGCTCACC ACAACCTCCG CCTCTGGGGT TCAAGTGATT CTCCTGCCTC AGCCTCCCGA 
GTAGCTGGGA TTACAGGTAT GTTTCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNRG ( NM_199464.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_955751.1 Homo sapiens potassium channel regulator (KCNRG), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02828
Clone ID Related Accession (Same CDS sequence)	NM_199464.3 , NM_199464.2
Accession Version	NM_199464.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	potassium channel regulatory protein isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY169387.1 and BX116021.1. On Feb 9, 2012 this sequence version replaced NM_199464.1. Transcript Variant: This variant (2) contains an alternate exon which results in a frameshift compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AY169387.1, BC020887.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144333, SAMEA2156099 [ECO:0000348] ##Evidence-Data-END##

ATGAGTAGTC AGGAACTGGT CACTTTGAAT GTGGGAGGGA AGATATTCAC GACAAGGTTT 
TCTACGATAA AGCAGTTTCC TGCTTCTCGT TTGGCACGCA TGTTAGATGG CAGAGACCAA 
GAATTCAAGA TGGTTGGTGG CCAGATTTTT GTAGACAGAG ATGGTGATTT GTTTAGTTTC 
ATCTTAGATT TTTTGAGAAC TCACCAGCTT TTATTACCCA CTGAATTTTC AGACTATCTT 
AGGCTTCAGA GAGAGGCTCT TTTCTATGAA CTTCGTTCTC TAGTTGATCT CTTAAACCCA 
TACCTGCTAC AGCCAAGACC TGCTCTTGTG GAGGTACATT TCCTAAGCCG GAACACTCAA 
GCTTTTTTCA GGGTGTTTGG CTCTTGCAGC AAAACAATTG AGATGCTAAC AGGGAGGATT 
ACAGTGTTTA CAGAACAACC TTCAGCGCCG ACCTGGAATG GTAACTTTTT CCCTCCTCAG 
ATGACCTTAC TTCCACTGCC TCCACAAAGA CCTTCTTACC ATGACCTGGT TTTCCAGTGT 
GGTTCTGACA GCACTACTGA TAACCAAACT GGAGTCAGGC TGGTATGCAA TGGCGTGATC 
TCGGCTCACC ACAACCTCCG CCTCTGGGGT TCAAGTGATT CTCCTGCCTC AGCCTCCCGA 
GTAGCTGGGA TTACAGGTAT GTTTCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_955751.1
CDS	241..930
Translation	MSSQELVTLNVGGKIFTTRFSTIKQFPASRLARMLDGRDQEFKMVGGQIFVDRDGDLFSFILDFLRTHQLLLPTEFSDYLRLQREALFYELRSLVDLLNPYLLQPRPALVEVHFLSRNTQAFFRVFGSCSKTIEMLTGRITVFTEQPSAPTWNGNFFPPQMTLLPLPPQRPSYHDLVFQCGSDSTTDNQTGVRLVCNGVISAHHNLRLWGSSDSPASASRVAGITGMFL

Target ORF information:

RefSeq Version	NM_199464.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium channel regulator (KCNRG), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199464.2

ORF Insert Sequence:

ATGAGTAGTC AGGAACTGGT CACTTTGAAT GTGGGAGGGA AGATATTCAC GACAAGGTTT 
TCTACGATAA AGCAGTTTCC TGCTTCTCGT TTGGCACGCA TGTTAGATGG CAGAGACCAA 
GAATTCAAGA TGGTTGGTGG CCAGATTTTT GTAGACAGAG ATGGTGATTT GTTTAGTTTC 
ATCTTAGATT TTTTGAGAAC TCACCAGCTT TTATTACCCA CTGAATTTTC AGACTATCTT 
AGGCTTCAGA GAGAGGCTCT TTTCTATGAA CTTCGTTCTC TAGTTGATCT CTTAAACCCA 
TACCTGCTAC AGCCAAGACC TGCTCTTGTG GAGGTACATT TCCTAAGCCG GAACACTCAA 
GCTTTTTTCA GGGTGTTTGG CTCTTGCAGC AAAACAATTG AGATGCTAAC AGGGAGGATT 
ACAGTGTTTA CAGAACAACC TTCAGCGCCG ACCTGGAATG GTAACTTTTT CCCTCCTCAG 
ATGACCTTAC TTCCACTGCC TCCACAAAGA CCTTCTTACC ATGACCTGGT TTTCCAGTGT 
GGTTCTGACA GCACTACTGA TAACCAAACT GGAGTCAGGC TGGTATGCAA TGGCGTGATC 
TCGGCTCACC ACAACCTCCG CCTCTGGGGT TCAAGTGATT CTCCTGCCTC AGCCTCCCGA 
GTAGCTGGGA TTACAGGTAT GTTTCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pro-apoptotic and antiproliferative activity of human KCNRG, a putative tumor suppressor in 13q14 region.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine31(1)33-45(2010 Jan)
Birerdinc A,Nohelty E,Marakhonov A,Manyam G,Panov I,Coon S,Nikitin E,Skoblov M,Chandhoke V,Baranova A

Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels.
Biochemical and biophysical research communications391(3)1301-5(2010 Jan)
Usman H,Mathew MK

Shifted Transversal Design smart-pooling for high coverage interactome mapping.
Genome research19(7)1262-9(2009 Jul)
Xin X,Rual JF,Hirozane-Kishikawa T,Hill DE,Vidal M,Boone C,Thierry-Mieg N

Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigen.
Proceedings of the National Academy of Sciences of the United States of America106(11)4396-401(2009 Mar)
Alimohammadi M,Dubois N,Sk?ldberg F,Hallgren A,Tardivel I,Hedstrand H,Haavik J,Husebye ES,Gustafsson J,Rorsman F,Meloni A,Janson C,Vialettes B,Kajosaari M,Egner W,Sargur R,Pont?n F,Amoura Z,Grimfeld A,De Luca F,Betterle C,Perheentupa J,K?mpe O,Carel JC

Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas.
Experimental & molecular medicine38(3)247-55(2006 Jun)
Cho YG,Kim CJ,Song JH,Rhie DJ,Park YK,Kim SY,Nam SW,Yoo NJ,Lee JY,Park WS

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KCNRG cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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