GP9 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GP9
Entrez Gene ID	2815
Full Name	glycoprotein IX platelet
Synonyms	CD42a,GPIX
General protein information	Preferred Names glycoprotein IX platelet Names platelet glycoprotein IX glycoprotein 9
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q21.3
Summary	This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq, Oct 2008].
Disorder MIM:	173515
Disorder Html:	Bernard-Soulier syndrome, type C, 231200 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000174.4	NP_000165.1	platelet glycoprotein IX precursor
XM_011512701.1	XP_011511003.1	platelet glycoprotein IX isoform X1
XM_005247374.3	XP_005247431.1	platelet glycoprotein IX isoform X1
XM_011512702.1	XP_011511004.1	platelet glycoprotein IX isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	GP9	XP_852017.1
Mus musculus (house mouse)	Gp9	NP_061232.1
	GP9	NP_001135785.1
Homo sapiens (human)	GP9	NP_000165.1
Pan troglodytes (chimpanzee)	GP9	XP_001140600.1
Bos taurus (cattle)	GP9	XP_005223237.1
Rattus norvegicus (Norway rat)	Gp9	NP_001026995.1
Gallus gallus (chicken)	GP9	XP_414314.1

Gene Ontology
Bibliography

Related articles in PubMed

The BEACH-domain containing protein, Nbeal2, interacts with Dock7, Sec16a and Vac14.
Mayer L, Jasztal M, Pardo M, Aguera de Haro S, Collins J, Bariana TK, Smethurst PA, Grassi L, Petersen R, Nurden P, Favier R, Yu L, Meacham S, Astle WJ, Choudhary J, Yue WW, Ouwehand WH, Guerrero JA
Blood(2017 Nov)

Cab4b, the first human platelet antigen carried by glycoprotein IX discovered in a context of severe neonatal thrombocytopenia.
Jallu V, Beranger T, Bianchi F, Casale C, Chenet C, Ferre N, Philippe S, Quesne J, Martageix C, Petermann R
Journal of thrombosis and haemostasis : JTH15(8)1646-1654(2017 Aug)

Extracellular signal-regulated kinase 5 associates with casein kinase II to regulate GPIb-IX-mediated platelet activation via the PTEN/PI3K/Akt pathway.
Cheng Z, Gao W, Fan X, Chen X, Mei H, Liu J, Luo X, Hu Y
Journal of thrombosis and haemostasis : JTH15(8)1679-1688(2017 Aug)

The Transmembrane Domains of ? and IX Subunits Mediate the Localization of the Platelet Glycoprotein Ib-IX Complex to the Glycosphingolipid-enriched Membrane Domain.
Xu G, Shang D, Zhang Z, Shaw TS, Ran Y, L?pez JA, Peng Y
The Journal of biological chemistry290(36)22155-62(2015 Sep)

Novel genetic abnormalities in Bernard-Soulier syndrome in India.
Ali S, Ghosh K, Shetty S
Annals of hematology93(3)381-4(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that localization of the GP Ib-IX complex to the lipid domain is mediated by GP Ibbeta and GP IX transmembrane domains.
Title: The Transmembrane Domains of ? and IX Subunits Mediate the Localization of the Platelet Glycoprotein Ib-IX Complex to the Glycosphingolipid-enriched Membrane Domain.

genetic association study in population in western India: Data suggest novel mutations in platelet glycoprotein Ib (GP1BA, GP1BB) and GP9 are associated with Bernard-Soulier syndrome in subjects studies; of 12 mutations identified, ten were novel.
Title: Novel genetic abnormalities in Bernard-Soulier syndrome in India.

Studies indicate that platelets from Bernard-Soulier syndrome (BSS) are defective in glycoprotein (GP)Ib-IX-V, a platelet-specific adhesion-signaling complex, composed of GPIbalpha disulfide linked to GPIbbeta, and noncovalently associated with GPIX and GPV.
Title: Bernard-Soulier syndrome: an update.

GPIX increased the expression of GPIba by promoting the formation of a disulfide bond between GPIba and GPIbb in transfected CHO-K1 cells.
Title: Platelets with a W127X mutation in GPIX express sufficient residual amounts of GPIb? to support adhesion to von Willebrand factor and collagen.

GPIbbeta missense mutations from Bernard-Soulier syndrome were examined for changes to GPIb-IX complex surface expression. Mutations A108P and P74R were found to maintain normal secretion/folding of GPIbbeta(E) but were unable to support GPIX surface expression
Title: Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIb? and a GPIb?/GPIX chimera.

The following GP9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GP9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18917	NM_000174.4 Latest version!	Homo sapiens glycoprotein IX platelet (GP9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18917	XM_011512702.1 Latest version!	Homo sapiens glycoprotein IX platelet (GP9), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18917	XM_005247374.3 Latest version!	Homo sapiens glycoprotein IX platelet (GP9), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18917	XM_011512701.1 Latest version!	Homo sapiens glycoprotein IX platelet (GP9), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GP9 ( NM_000174.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000165.1 Homo sapiens glycoprotein IX platelet (GP9), mRNA.

Price & Availability↑

CloneID	OHu18917
Clone ID Related Accession (Same CDS sequence)	NM_000174.4 , XM_011512701.1 , XM_005247374.3 , XM_011512702.1
Accession Version	NM_000174.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 534bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	platelet glycoprotein IX precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X52997.1, BC030229.1 and BM971739.1. This sequence is a reference standard in the RefSeqGene project. On Aug 16, 2014 this sequence version replaced NM_000174.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X52997.1, BC030229.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTGCCT GGGGAGCCCT GTTCCTGCTC TGGGCCACAG CAGAGGCCAC CAAGGACTGC 
CCCAGCCCAT GTACCTGCCG CGCCCTGGAA ACCATGGGGC TGTGGGTGGA CTGCAGGGGC 
CACGGACTCA CGGCCCTGCC TGCCCTGCCG GCCCGCACCC GCCACCTTCT GCTGGCCAAC 
AACAGCCTTC AGTCCGTGCC CCCGGGAGCC TTTGACCACC TGCCCCAGCT GCAGACCCTC 
GATGTGACGC AGAACCCCTG GCACTGTGAC TGCAGCCTCA CCTATCTGCG CCTCTGGCTG 
GAGGACCGCA CGCCCGAGGC CCTGCTGCAG GTCCGCTGTG CCAGCCCCAG CCTCGCTGCC 
CATGGCCCGC TGGGCCGGCT GACAGGCTAC CAGCTGGGCA GCTGTGGCTG GCAGCTGCAG 
GCGTCCTGGG TGCGCCCGGG GGTCTTGTGG GACGTGGCGC TGGTCGCCGT GGCCGCGCTG 
GGCCTGGCTC TTCTGGCTGG CCTGCTGTGT GCCACCACAG AGGCCCTGGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000165.1
CDS	223..756
Translation	MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLANNSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAAHGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD

Target ORF information:

RefSeq Version	NM_000174.4
Organism	Homo sapiens(human)
Definition	Homo sapiens glycoprotein IX platelet (GP9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000174.4

ORF Insert Sequence:

ATGCCTGCCT GGGGAGCCCT GTTCCTGCTC TGGGCCACAG CAGAGGCCAC CAAGGACTGC 
CCCAGCCCAT GTACCTGCCG CGCCCTGGAA ACCATGGGGC TGTGGGTGGA CTGCAGGGGC 
CACGGACTCA CGGCCCTGCC TGCCCTGCCG GCCCGCACCC GCCACCTTCT GCTGGCCAAC 
AACAGCCTTC AGTCCGTGCC CCCGGGAGCC TTTGACCACC TGCCCCAGCT GCAGACCCTC 
GATGTGACGC AGAACCCCTG GCACTGTGAC TGCAGCCTCA CCTATCTGCG CCTCTGGCTG 
GAGGACCGCA CGCCCGAGGC CCTGCTGCAG GTCCGCTGTG CCAGCCCCAG CCTCGCTGCC 
CATGGCCCGC TGGGCCGGCT GACAGGCTAC CAGCTGGGCA GCTGTGGCTG GCAGCTGCAG 
GCGTCCTGGG TGCGCCCGGG GGTCTTGTGG GACGTGGCGC TGGTCGCCGT GGCCGCGCTG 
GGCCTGGCTC TTCTGGCTGG CCTGCTGTGT GCCACCACAG AGGCCCTGGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GP9 ( XM_011512701.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011511003.1 Homo sapiens glycoprotein IX platelet (GP9), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu18917
Clone ID Related Accession (Same CDS sequence)	NM_000174.4 , XM_011512701.1 , XM_005247374.3 , XM_011512702.1
Accession Version	XM_011512701.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 534bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	platelet glycoprotein IX isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTGCCT GGGGAGCCCT GTTCCTGCTC TGGGCCACAG CAGAGGCCAC CAAGGACTGC 
CCCAGCCCAT GTACCTGCCG CGCCCTGGAA ACCATGGGGC TGTGGGTGGA CTGCAGGGGC 
CACGGACTCA CGGCCCTGCC TGCCCTGCCG GCCCGCACCC GCCACCTTCT GCTGGCCAAC 
AACAGCCTTC AGTCCGTGCC CCCGGGAGCC TTTGACCACC TGCCCCAGCT GCAGACCCTC 
GATGTGACGC AGAACCCCTG GCACTGTGAC TGCAGCCTCA CCTATCTGCG CCTCTGGCTG 
GAGGACCGCA CGCCCGAGGC CCTGCTGCAG GTCCGCTGTG CCAGCCCCAG CCTCGCTGCC 
CATGGCCCGC TGGGCCGGCT GACAGGCTAC CAGCTGGGCA GCTGTGGCTG GCAGCTGCAG 
GCGTCCTGGG TGCGCCCGGG GGTCTTGTGG GACGTGGCGC TGGTCGCCGT GGCCGCGCTG 
GGCCTGGCTC TTCTGGCTGG CCTGCTGTGT GCCACCACAG AGGCCCTGGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011511003.1
CDS	601..1134
Translation	MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLANNSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAAHGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD

Target ORF information:

RefSeq Version	XM_011512701.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glycoprotein IX platelet (GP9), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011512701.1

ORF Insert Sequence:

ATGCCTGCCT GGGGAGCCCT GTTCCTGCTC TGGGCCACAG CAGAGGCCAC CAAGGACTGC 
CCCAGCCCAT GTACCTGCCG CGCCCTGGAA ACCATGGGGC TGTGGGTGGA CTGCAGGGGC 
CACGGACTCA CGGCCCTGCC TGCCCTGCCG GCCCGCACCC GCCACCTTCT GCTGGCCAAC 
AACAGCCTTC AGTCCGTGCC CCCGGGAGCC TTTGACCACC TGCCCCAGCT GCAGACCCTC 
GATGTGACGC AGAACCCCTG GCACTGTGAC TGCAGCCTCA CCTATCTGCG CCTCTGGCTG 
GAGGACCGCA CGCCCGAGGC CCTGCTGCAG GTCCGCTGTG CCAGCCCCAG CCTCGCTGCC 
CATGGCCCGC TGGGCCGGCT GACAGGCTAC CAGCTGGGCA GCTGTGGCTG GCAGCTGCAG 
GCGTCCTGGG TGCGCCCGGG GGTCTTGTGG GACGTGGCGC TGGTCGCCGT GGCCGCGCTG 
GGCCTGGCTC TTCTGGCTGG CCTGCTGTGT GCCACCACAG AGGCCCTGGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GP9 ( XM_005247374.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005247431.1 Homo sapiens glycoprotein IX platelet (GP9), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu18917
Clone ID Related Accession (Same CDS sequence)	NM_000174.4 , XM_011512701.1 , XM_005247374.3 , XM_011512702.1
Accession Version	XM_005247374.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 534bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	platelet glycoprotein IX isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005247374.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTGCCT GGGGAGCCCT GTTCCTGCTC TGGGCCACAG CAGAGGCCAC CAAGGACTGC 
CCCAGCCCAT GTACCTGCCG CGCCCTGGAA ACCATGGGGC TGTGGGTGGA CTGCAGGGGC 
CACGGACTCA CGGCCCTGCC TGCCCTGCCG GCCCGCACCC GCCACCTTCT GCTGGCCAAC 
AACAGCCTTC AGTCCGTGCC CCCGGGAGCC TTTGACCACC TGCCCCAGCT GCAGACCCTC 
GATGTGACGC AGAACCCCTG GCACTGTGAC TGCAGCCTCA CCTATCTGCG CCTCTGGCTG 
GAGGACCGCA CGCCCGAGGC CCTGCTGCAG GTCCGCTGTG CCAGCCCCAG CCTCGCTGCC 
CATGGCCCGC TGGGCCGGCT GACAGGCTAC CAGCTGGGCA GCTGTGGCTG GCAGCTGCAG 
GCGTCCTGGG TGCGCCCGGG GGTCTTGTGG GACGTGGCGC TGGTCGCCGT GGCCGCGCTG 
GGCCTGGCTC TTCTGGCTGG CCTGCTGTGT GCCACCACAG AGGCCCTGGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005247431.1
CDS	519..1052
Translation	MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLANNSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAAHGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD

Target ORF information:

RefSeq Version	XM_005247374.3
Organism	Homo sapiens(human)
Definition	Homo sapiens glycoprotein IX platelet (GP9), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005247374.3

ORF Insert Sequence:

ATGCCTGCCT GGGGAGCCCT GTTCCTGCTC TGGGCCACAG CAGAGGCCAC CAAGGACTGC 
CCCAGCCCAT GTACCTGCCG CGCCCTGGAA ACCATGGGGC TGTGGGTGGA CTGCAGGGGC 
CACGGACTCA CGGCCCTGCC TGCCCTGCCG GCCCGCACCC GCCACCTTCT GCTGGCCAAC 
AACAGCCTTC AGTCCGTGCC CCCGGGAGCC TTTGACCACC TGCCCCAGCT GCAGACCCTC 
GATGTGACGC AGAACCCCTG GCACTGTGAC TGCAGCCTCA CCTATCTGCG CCTCTGGCTG 
GAGGACCGCA CGCCCGAGGC CCTGCTGCAG GTCCGCTGTG CCAGCCCCAG CCTCGCTGCC 
CATGGCCCGC TGGGCCGGCT GACAGGCTAC CAGCTGGGCA GCTGTGGCTG GCAGCTGCAG 
GCGTCCTGGG TGCGCCCGGG GGTCTTGTGG GACGTGGCGC TGGTCGCCGT GGCCGCGCTG 
GGCCTGGCTC TTCTGGCTGG CCTGCTGTGT GCCACCACAG AGGCCCTGGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GP9 ( XM_011512702.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011511004.1 Homo sapiens glycoprotein IX platelet (GP9), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu18917
Clone ID Related Accession (Same CDS sequence)	NM_000174.4 , XM_011512701.1 , XM_005247374.3 , XM_011512702.1
Accession Version	XM_011512702.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 534bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	platelet glycoprotein IX isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTGCCT GGGGAGCCCT GTTCCTGCTC TGGGCCACAG CAGAGGCCAC CAAGGACTGC 
CCCAGCCCAT GTACCTGCCG CGCCCTGGAA ACCATGGGGC TGTGGGTGGA CTGCAGGGGC 
CACGGACTCA CGGCCCTGCC TGCCCTGCCG GCCCGCACCC GCCACCTTCT GCTGGCCAAC 
AACAGCCTTC AGTCCGTGCC CCCGGGAGCC TTTGACCACC TGCCCCAGCT GCAGACCCTC 
GATGTGACGC AGAACCCCTG GCACTGTGAC TGCAGCCTCA CCTATCTGCG CCTCTGGCTG 
GAGGACCGCA CGCCCGAGGC CCTGCTGCAG GTCCGCTGTG CCAGCCCCAG CCTCGCTGCC 
CATGGCCCGC TGGGCCGGCT GACAGGCTAC CAGCTGGGCA GCTGTGGCTG GCAGCTGCAG 
GCGTCCTGGG TGCGCCCGGG GGTCTTGTGG GACGTGGCGC TGGTCGCCGT GGCCGCGCTG 
GGCCTGGCTC TTCTGGCTGG CCTGCTGTGT GCCACCACAG AGGCCCTGGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011511004.1
CDS	476..1009
Translation	MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLANNSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAAHGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD

Target ORF information:

RefSeq Version	XM_011512702.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glycoprotein IX platelet (GP9), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011512702.1

ORF Insert Sequence:

ATGCCTGCCT GGGGAGCCCT GTTCCTGCTC TGGGCCACAG CAGAGGCCAC CAAGGACTGC 
CCCAGCCCAT GTACCTGCCG CGCCCTGGAA ACCATGGGGC TGTGGGTGGA CTGCAGGGGC 
CACGGACTCA CGGCCCTGCC TGCCCTGCCG GCCCGCACCC GCCACCTTCT GCTGGCCAAC 
AACAGCCTTC AGTCCGTGCC CCCGGGAGCC TTTGACCACC TGCCCCAGCT GCAGACCCTC 
GATGTGACGC AGAACCCCTG GCACTGTGAC TGCAGCCTCA CCTATCTGCG CCTCTGGCTG 
GAGGACCGCA CGCCCGAGGC CCTGCTGCAG GTCCGCTGTG CCAGCCCCAG CCTCGCTGCC 
CATGGCCCGC TGGGCCGGCT GACAGGCTAC CAGCTGGGCA GCTGTGGCTG GCAGCTGCAG 
GCGTCCTGGG TGCGCCCGGG GGTCTTGTGG GACGTGGCGC TGGTCGCCGT GGCCGCGCTG 
GGCCTGGCTC TTCTGGCTGG CCTGCTGTGT GCCACCACAG AGGCCCTGGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The BEACH-domain containing protein, Nbeal2, interacts with Dock7, Sec16a and Vac14.
Blood(2017 Nov)
Mayer L,Jasztal M,Pardo M,Aguera de Haro S,Collins J,Bariana TK,Smethurst PA,Grassi L,Petersen R,Nurden P,Favier R,Yu L,Meacham S,Astle WJ,Choudhary J,Yue WW,Ouwehand WH,Guerrero JA

Cab4b, the first human platelet antigen carried by glycoprotein IX discovered in a context of severe neonatal thrombocytopenia.
Journal of thrombosis and haemostasis : JTH15(8)1646-1654(2017 Aug)
Jallu V,Beranger T,Bianchi F,Casale C,Chenet C,Ferre N,Philippe S,Quesne J,Martageix C,Petermann R

Extracellular signal-regulated kinase 5 associates with casein kinase II to regulate GPIb-IX-mediated platelet activation via the PTEN/PI3K/Akt pathway.
Journal of thrombosis and haemostasis : JTH15(8)1679-1688(2017 Aug)
Cheng Z,Gao W,Fan X,Chen X,Mei H,Liu J,Luo X,Hu Y

The Transmembrane Domains of ? and IX Subunits Mediate the Localization of the Platelet Glycoprotein Ib-IX Complex to the Glycosphingolipid-enriched Membrane Domain.
The Journal of biological chemistry290(36)22155-62(2015 Sep)
Xu G,Shang D,Zhang Z,Shaw TS,Ran Y,L?pez JA,Peng Y

Novel genetic abnormalities in Bernard-Soulier syndrome in India.
Annals of hematology93(3)381-4(2014 Mar)
Ali S,Ghosh K,Shetty S

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GP9 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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