GNGT2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GNGT2
Entrez Gene ID	2793
Full Name	G protein subunit gamma transducin 2
Synonyms	G-GAMMA-8,G-GAMMA-C,GNG8,GNG9,GNGT8
General protein information	Preferred Names G protein subunit gamma transducin 2 Names guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 G protein cone gamma 8 subunit G-gamma-9 g gamma-C gamma-T2 subunit guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 guanine nucleotide binding protein gamma 9 guanine nucleotide binding protein gamma transducing activity polypeptide 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.32
Summary	Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010].
Disorder MIM:	139391

mRNA and Protein(s)

mRNA	Protein	Name
NM_001198755.1	NP_001185684.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
NM_001198756.1	NP_001185685.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
NM_031498.2	NP_113686.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
NM_001198754.1	NP_001185683.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
NM_001198754.2	NP_001185683.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

Pathways from BioSystems

Homologies

Homo sapiens (human)	GNGT2	NP_001185683.1
Pan troglodytes (chimpanzee)	GNGT2	XP_001172623.1
Xenopus tropicalis (tropical clawed frog)	gngt2	NP_001165091.1
Canis lupus familiaris (dog)	GNGT2	NP_001003071.1
Mus musculus (house mouse)	Gngt2	NP_001033753.2
Gallus gallus (chicken)	LOC100859179	XP_003642837.1
Danio rerio (zebrafish)	gngt2a	XP_001337030.1
	GNGT2	XP_001092081.1
Bos taurus (cattle)	GNGT2	NP_776753.1
Rattus norvegicus (Norway rat)	Gngt2	NP_001129239.1
Xenopus tropicalis (tropical clawed frog)	gngt2.1	NP_001165092.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
Eeles RA, Olama AA, Benlloch S, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Ghoussaini M, Luccarini C, Dennis J, Jugurnauth-Little S, Dadaev T, Neal DE, Hamdy FC, Donovan JL, Muir K, Giles GG, Severi G, Wiklund F, Gronberg H, Haiman CA, Schumacher F, Henderson BE, Le Marchand L, Lindstrom S, Kraft P, Hunter DJ, Gapstur S, Chanock SJ, Berndt SI, Albanes D, Andriole G, Schleutker J, Weischer M, Canzian F, Riboli E, Key TJ, Travis RC, Campa D, Ingles SA, John EM, Hayes RB, Pharoah PD, Pashayan N, Khaw KT, Stanford JL, Ostrander EA, Signorello LB, Thibodeau SN, Schaid D, Maier C, Vogel W, Kibel AS, Cybulski C, Lubinski J, Cannon-Albright L, Brenner H, Park JY, Kaneva R, Batra J, Spurdle AB, Clements JA, Teixeira MR, Dicks E, Lee A, Dunning AM, Baynes C, Conroy D, Maranian MJ, Ahmed S, Govindasami K, Guy M, Wilkinson RA, Sawyer EJ, Morgan A, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As NJ, Woodhouse CJ, Thompson A, Dudderidge T, Ogden C, Cooper CS, Lophatananon A, Cox A, Southey MC, Hopper JL, English DR, Aly M, Adolfsson J, Xu J, Zheng SL, Yeager M, Kaaks R, Diver WR, Gaudet MM, Stern MC, Corral R, Joshi AD, Shahabi A, Wahlfors T, Tammela TL, Auvinen A, Virtamo J, Klarskov P, Nordestgaard BG, R?der MA, Nielsen SF, Bojesen SE, Siddiq A, Fitzgerald LM, Kolb S, Kwon EM, Karyadi DM, Blot WJ, Zheng W, Cai Q, McDonnell SK, Rinckleb AE, Drake B, Colditz G, Wokolorczyk D, Stephenson RA, Teerlink C, Muller H, Rothenbacher D, Sellers TA, Lin HY, Slavov C, Mitev V, Lose F, Srinivasan S, Maia S, Paulo P, Lange E, Cooney KA, Antoniou AC, Vincent D, Bacot F, Tessier DC, , , , , , Kote-Jarai Z, Easton DF
Nature genetics45(4)385-91, 391e1-2(2013 Apr)

beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation.
Yang M, He RL, Benovic JL, Ye RD
The Biochemical journal417(1)287-96(2009 Jan)

Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.
Fowler CE, Aryal P, Suen KF, Slesinger PA
The Journal of physiology580(Pt 1)51-65(2007 Apr)

The molecular basis for T-type Ca2+ channel inhibition by G protein beta2gamma2 subunits.
DePuy SD, Yao J, Hu C, McIntire W, Bidaud I, Lory P, Rastinejad F, Gonzalez C, Garrison JC, Barrett PQ
Proceedings of the National Academy of Sciences of the United States of America103(39)14590-5(2006 Sep)

Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel.
Ivanina T, Rishal I, Varon D, Mullner C, Frohnwieser-Steinecke B, Schreibmayer W, Dessauer CW, Dascal N
The Journal of biological chemistry278(31)29174-83(2003 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results identify novel functions of beta-arrestin1 in binding to the beta1gamma2 subunits of heterotrimeric G-proteins and promoting G(betagamma)-mediated Akt signalling for NF-kappaB activation.
Title: beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation.

Recombinant Gbetagamma subunits were used to establish that the Gbeta(2)gamma(2) dimer can selectively reconstitute the inhibition of alpha(1H) channels in isolated membrane patches.
Title: The molecular basis for T-type Ca2+ channel inhibition by G protein beta2gamma2 subunits.

The following GNGT2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GNGT2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08363	NM_001198755.1 Latest version!	Homo sapiens G protein subunit gamma transducin 2 (GNGT2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu08363	NM_001198754.2 Latest version!	Homo sapiens G protein subunit gamma transducin 2 (GNGT2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu08363	NM_031498.2 Latest version!	Homo sapiens G protein subunit gamma transducin 2 (GNGT2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu08363	NM_001198756.1 Latest version!	Homo sapiens G protein subunit gamma transducin 2 (GNGT2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu08363	NM_001198754.1	Homo sapiens G protein subunit gamma transducin 2 (GNGT2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GNGT2 ( NM_001198755.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001185684.1 Homo sapiens G protein subunit gamma transducin 2 (GNGT2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu08363
Clone ID Related Accession (Same CDS sequence)	NM_001198755.1 , NM_001198756.1 , NM_031498.2 , NM_001198754.1 , NM_001198754.2
Accession Version	NM_001198755.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 210bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK312839.1, AC069454.22 and BU742490.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK312839.1, DB148559.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCAGG ATCTCAGCGA GAAGGACCTG TTGAAGATGG AGGTGGAGCA GCTGAAGAAA 
GAAGTGAAAA ACACAAGAAT TCCGATTTCC AAAGCGGGAA AGGAAATCAA GGAGTACGTG 
GAGGCCCAAG CAGGAAACGA TCCTTTTCTC AAAGGCATCC CTGAGGACAA GAATCCCTTC 
AAGGAGAAAG GTGGCTGTCT GATAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001185684.1
CDS	291..500
Translation	MAQDLSEKDLLKMEVEQLKKEVKNTRIPISKAGKEIKEYVEAQAGNDPFLKGIPEDKNPFKEKGGCLIS

Target ORF information:

RefSeq Version	NM_001198755.1
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit gamma transducin 2 (GNGT2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001198755.1

ORF Insert Sequence:

ATGGCCCAGG ATCTCAGCGA GAAGGACCTG TTGAAGATGG AGGTGGAGCA GCTGAAGAAA 
GAAGTGAAAA ACACAAGAAT TCCGATTTCC AAAGCGGGAA AGGAAATCAA GGAGTACGTG 
GAGGCCCAAG CAGGAAACGA TCCTTTTCTC AAAGGCATCC CTGAGGACAA GAATCCCTTC 
AAGGAGAAAG GTGGCTGTCT GATAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNGT2 ( NM_001198756.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001185685.1 Homo sapiens G protein subunit gamma transducin 2 (GNGT2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu08363
Clone ID Related Accession (Same CDS sequence)	NM_001198755.1 , NM_001198756.1 , NM_031498.2 , NM_001198754.1 , NM_001198754.2
Accession Version	NM_001198756.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 210bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM723861.1, AC069454.22 and BU742490.1. Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM723861.1, SRR1803614.236879.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCAGG ATCTCAGCGA GAAGGACCTG TTGAAGATGG AGGTGGAGCA GCTGAAGAAA 
GAAGTGAAAA ACACAAGAAT TCCGATTTCC AAAGCGGGAA AGGAAATCAA GGAGTACGTG 
GAGGCCCAAG CAGGAAACGA TCCTTTTCTC AAAGGCATCC CTGAGGACAA GAATCCCTTC 
AAGGAGAAAG GTGGCTGTCT GATAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001185685.1
CDS	181..390
Translation	MAQDLSEKDLLKMEVEQLKKEVKNTRIPISKAGKEIKEYVEAQAGNDPFLKGIPEDKNPFKEKGGCLIS

Target ORF information:

RefSeq Version	NM_001198756.1
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit gamma transducin 2 (GNGT2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001198756.1

ORF Insert Sequence:

ATGGCCCAGG ATCTCAGCGA GAAGGACCTG TTGAAGATGG AGGTGGAGCA GCTGAAGAAA 
GAAGTGAAAA ACACAAGAAT TCCGATTTCC AAAGCGGGAA AGGAAATCAA GGAGTACGTG 
GAGGCCCAAG CAGGAAACGA TCCTTTTCTC AAAGGCATCC CTGAGGACAA GAATCCCTTC 
AAGGAGAAAG GTGGCTGTCT GATAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNGT2 ( NM_031498.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_113686.1 Homo sapiens G protein subunit gamma transducin 2 (GNGT2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu08363
Clone ID Related Accession (Same CDS sequence)	NM_001198755.1 , NM_001198756.1 , NM_031498.2 , NM_001198754.1 , NM_001198754.2
Accession Version	NM_031498.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 210bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC008663.1, AI857683.1 and BU742490.1. This sequence is a reference standard in the RefSeqGene project. On Jan 24, 2009 this sequence version replaced NM_031498.1. Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008663.1, BE618270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCAGG ATCTCAGCGA GAAGGACCTG TTGAAGATGG AGGTGGAGCA GCTGAAGAAA 
GAAGTGAAAA ACACAAGAAT TCCGATTTCC AAAGCGGGAA AGGAAATCAA GGAGTACGTG 
GAGGCCCAAG CAGGAAACGA TCCTTTTCTC AAAGGCATCC CTGAGGACAA GAATCCCTTC 
AAGGAGAAAG GTGGCTGTCT GATAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113686.1
CDS	308..517
Translation	MAQDLSEKDLLKMEVEQLKKEVKNTRIPISKAGKEIKEYVEAQAGNDPFLKGIPEDKNPFKEKGGCLIS

Target ORF information:

RefSeq Version	NM_031498.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit gamma transducin 2 (GNGT2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031498.2

ORF Insert Sequence:

ATGGCCCAGG ATCTCAGCGA GAAGGACCTG TTGAAGATGG AGGTGGAGCA GCTGAAGAAA 
GAAGTGAAAA ACACAAGAAT TCCGATTTCC AAAGCGGGAA AGGAAATCAA GGAGTACGTG 
GAGGCCCAAG CAGGAAACGA TCCTTTTCTC AAAGGCATCC CTGAGGACAA GAATCCCTTC 
AAGGAGAAAG GTGGCTGTCT GATAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNGT2 ( NM_001198754.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001185683.1 Homo sapiens G protein subunit gamma transducin 2 (GNGT2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08363
Clone ID Related Accession (Same CDS sequence)	NM_001198755.1 , NM_001198756.1 , NM_031498.2 , NM_001198754.1 , NM_001198754.2
Accession Version	NM_001198754.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 210bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA248836.1, AC069454.22 and BU742490.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA248836.1, SRR1163658.569967.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCAGG ATCTCAGCGA GAAGGACCTG TTGAAGATGG AGGTGGAGCA GCTGAAGAAA 
GAAGTGAAAA ACACAAGAAT TCCGATTTCC AAAGCGGGAA AGGAAATCAA GGAGTACGTG 
GAGGCCCAAG CAGGAAACGA TCCTTTTCTC AAAGGCATCC CTGAGGACAA GAATCCCTTC 
AAGGAGAAAG GTGGCTGTCT GATAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001185683.1
CDS	264..473
Translation	MAQDLSEKDLLKMEVEQLKKEVKNTRIPISKAGKEIKEYVEAQAGNDPFLKGIPEDKNPFKEKGGCLIS

Target ORF information:

RefSeq Version	NM_001198754.1
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit gamma transducin 2 (GNGT2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001198754.1

ORF Insert Sequence:

ATGGCCCAGG ATCTCAGCGA GAAGGACCTG TTGAAGATGG AGGTGGAGCA GCTGAAGAAA 
GAAGTGAAAA ACACAAGAAT TCCGATTTCC AAAGCGGGAA AGGAAATCAA GGAGTACGTG 
GAGGCCCAAG CAGGAAACGA TCCTTTTCTC AAAGGCATCC CTGAGGACAA GAATCCCTTC 
AAGGAGAAAG GTGGCTGTCT GATAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNGT2 ( NM_001198754.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001185683.1 Homo sapiens G protein subunit gamma transducin 2 (GNGT2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08363
Clone ID Related Accession (Same CDS sequence)	NM_001198755.1 , NM_001198756.1 , NM_031498.2 , NM_001198754.1 , NM_001198754.2
Accession Version	NM_001198754.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 210bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA248836.1, AC069454.22 and BU742490.1. On Nov 23, 2018 this sequence version replaced NM_001198754.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.569967.1, SRR1803616.223574.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000507680.6/ ENSP00000421710.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCAGG ATCTCAGCGA GAAGGACCTG TTGAAGATGG AGGTGGAGCA GCTGAAGAAA 
GAAGTGAAAA ACACAAGAAT TCCGATTTCC AAAGCGGGAA AGGAAATCAA GGAGTACGTG 
GAGGCCCAAG CAGGAAACGA TCCTTTTCTC AAAGGCATCC CTGAGGACAA GAATCCCTTC 
AAGGAGAAAG GTGGCTGTCT GATAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001185683.1
CDS	264..473
Translation	MAQDLSEKDLLKMEVEQLKKEVKNTRIPISKAGKEIKEYVEAQAGNDPFLKGIPEDKNPFKEKGGCLIS

Target ORF information:

RefSeq Version	NM_001198754.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit gamma transducin 2 (GNGT2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001198754.2

ORF Insert Sequence:

ATGGCCCAGG ATCTCAGCGA GAAGGACCTG TTGAAGATGG AGGTGGAGCA GCTGAAGAAA 
GAAGTGAAAA ACACAAGAAT TCCGATTTCC AAAGCGGGAA AGGAAATCAA GGAGTACGTG 
GAGGCCCAAG CAGGAAACGA TCCTTTTCTC AAAGGCATCC CTGAGGACAA GAATCCCTTC 
AAGGAGAAAG GTGGCTGTCT GATAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
Nature genetics45(4)385-91, 391e1-2(2013 Apr)
Eeles RA,Olama AA,Benlloch S,Saunders EJ,Leongamornlert DA,Tymrakiewicz M,Ghoussaini M,Luccarini C,Dennis J,Jugurnauth-Little S,Dadaev T,Neal DE,Hamdy FC,Donovan JL,Muir K,Giles GG,Severi G,Wiklund F,Gronberg H,Haiman CA,Schumacher F,Henderson BE,Le Marchand L,Lindstrom S,Kraft P,Hunter DJ,Gapstur S,Chanock SJ,Berndt SI,Albanes D,Andriole G,Schleutker J,Weischer M,Canzian F,Riboli E,Key TJ,Travis RC,Campa D,Ingles SA,John EM,Hayes RB,Pharoah PD,Pashayan N,Khaw KT,Stanford JL,Ostrander EA,Signorello LB,Thibodeau SN,Schaid D,Maier C,Vogel W,Kibel AS,Cybulski C,Lubinski J,Cannon-Albright L,Brenner H,Park JY,Kaneva R,Batra J,Spurdle AB,Clements JA,Teixeira MR,Dicks E,Lee A,Dunning AM,Baynes C,Conroy D,Maranian MJ,Ahmed S,Govindasami K,Guy M,Wilkinson RA,Sawyer EJ,Morgan A,Dearnaley DP,Horwich A,Huddart RA,Khoo VS,Parker CC,Van As NJ,Woodhouse CJ,Thompson A,Dudderidge T,Ogden C,Cooper CS,Lophatananon A,Cox A,Southey MC,Hopper JL,English DR,Aly M,Adolfsson J,Xu J,Zheng SL,Yeager M,Kaaks R,Diver WR,Gaudet MM,Stern MC,Corral R,Joshi AD,Shahabi A,Wahlfors T,Tammela TL,Auvinen A,Virtamo J,Klarskov P,Nordestgaard BG,R?der MA,Nielsen SF,Bojesen SE,Siddiq A,Fitzgerald LM,Kolb S,Kwon EM,Karyadi DM,Blot WJ,Zheng W,Cai Q,McDonnell SK,Rinckleb AE,Drake B,Colditz G,Wokolorczyk D,Stephenson RA,Teerlink C,Muller H,Rothenbacher D,Sellers TA,Lin HY,Slavov C,Mitev V,Lose F,Srinivasan S,Maia S,Paulo P,Lange E,Cooney KA,Antoniou AC,Vincent D,Bacot F,Tessier DC,,,,,,Kote-Jarai Z,Easton DF

beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation.
The Biochemical journal417(1)287-96(2009 Jan)
Yang M,He RL,Benovic JL,Ye RD

Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.
The Journal of physiology580(Pt 1)51-65(2007 Apr)
Fowler CE,Aryal P,Suen KF,Slesinger PA

The molecular basis for T-type Ca2+ channel inhibition by G protein beta2gamma2 subunits.
Proceedings of the National Academy of Sciences of the United States of America103(39)14590-5(2006 Sep)
DePuy SD,Yao J,Hu C,McIntire W,Bidaud I,Lory P,Rastinejad F,Gonzalez C,Garrison JC,Barrett PQ

Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel.
The Journal of biological chemistry278(31)29174-83(2003 Aug)
Ivanina T,Rishal I,Varon D,Mullner C,Frohnwieser-Steinecke B,Schreibmayer W,Dessauer CW,Dascal N

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GNGT2 cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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