GNG5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GNG5
Entrez Gene ID	2787
Full Name	G protein subunit gamma 5
General protein information	Preferred Names G protein subunit gamma 5 Names guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 guanine nucleotide binding protein (G protein), gamma 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p22.3
Summary	G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010].
Disorder MIM:	600874

mRNA and Protein(s)

mRNA	Protein	Name
NM_005274.3	NP_005265.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 precursor
NM_005274.2	NP_005265.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GNG5	NP_005265.1
Pan troglodytes (chimpanzee)	GNG5	NP_001238951.1
	GNG5	XP_001107243.1
Canis lupus familiaris (dog)	GNG5	XP_003434843.1
Mus musculus (house mouse)	Gm15776	XP_003945606.1
Gallus gallus (chicken)	GNG5	XP_422375.4
Xenopus tropicalis (tropical clawed frog)	gng5	NP_001165076.1
Mus musculus (house mouse)	Gng5	NP_034448.2
Rattus norvegicus (Norway rat)	Gng5	NP_077353.1
Danio rerio (zebrafish)	gng5	NP_999886.1
Bos taurus (cattle)	GNG5	NP_777236.1

Gene Ontology
Bibliography

Related articles in PubMed

Association between single nucleotide polymorphisms of the G-protein ?5 subunit and the risk of essential hypertension in the population of Poland.
Hejduk P, Sakowicz AM, Miko?ajczyk M, ?liwi?ska A, Drzewoski J, Pietrucha T
Polskie Archiwum Medycyny Wewnetrznej125(12)903-9(2015)

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
Ahmed SM, Th?riault BL, Uppalapati M, Chiu CW, Gallie BL, Sidhu SS, Angers S
The Journal of cell biology199(6)951-67(2012 Dec)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

Changes in liver and spleen of normal and allergic rabbits after intraparenchymal injections of serum, and the modifications induced by oral administration of alcohol.
ROGERS WN
Quarterly journal of studies on alcohol7(3)325-40(1946 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

rs13093 in the promoter region of GNG5 may be associated with an increased risk of essential hypertension in the Polish population.
Title: Association between single nucleotide polymorphisms of the G-protein ?5 subunit and the risk of essential hypertension in the population of Poland.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following GNG5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GNG5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09122	NM_005274.3 Latest version!	Homo sapiens G protein subunit gamma 5 (GNG5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu09122	NM_005274.2	Homo sapiens G protein subunit gamma 5 (GNG5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GNG5 ( NM_005274.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005265.1 Homo sapiens G protein subunit gamma 5 (GNG5), mRNA.

Price & Availability↑

CloneID	OHu09122
Clone ID Related Accession (Same CDS sequence)	NM_005274.3 , NM_005274.2
Accession Version	NM_005274.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 207bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL359762.24, BM834854.1, BC003563.1 and BM809260.1. On Nov 23, 2018 this sequence version replaced NM_005274.2. [supplied by OMIM, Nov 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.612147.1, SRR5189661.2416.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370645.9/ ENSP00000359679.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTGGCT CCTCCAGCGT CGCCGCTATG AAGAAAGTGG TTCAACAGCT CCGGCTGGAG 
GCCGGACTCA ACCGCGTAAA AGTTTCCCAG GCAGCTGCAG ACTTGAAACA GTTCTGTCTG 
CAGAATGCTC AACATGACCC TCTGCTGACT GGAGTATCTT CAAGTACAAA TCCCTTCAGA 
CCCCAGAAAG TCTGTTCCTT TTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005265.1
CDS	357..563
Translation	MSGSSSVAAMKKVVQQLRLEAGLNRVKVSQAAADLKQFCLQNAQHDPLLTGVSSSTNPFRPQKVCSFL

Target ORF information:

RefSeq Version	NM_005274.3
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit gamma 5 (GNG5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005274.3

ORF Insert Sequence:

ATGTCTGGCT CCTCCAGCGT CGCCGCTATG AAGAAAGTGG TTCAACAGCT CCGGCTGGAG 
GCCGGACTCA ACCGCGTAAA AGTTTCCCAG GCAGCTGCAG ACTTGAAACA GTTCTGTCTG 
CAGAATGCTC AACATGACCC TCTGCTGACT GGAGTATCTT CAAGTACAAA TCCCTTCAGA 
CCCCAGAAAG TCTGTTCCTT TTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNG5 ( NM_005274.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005265.1 Homo sapiens G protein subunit gamma 5 (GNG5), mRNA.

Price & Availability↑

CloneID	OHu09122
Clone ID Related Accession (Same CDS sequence)	NM_005274.3 , NM_005274.2
Accession Version	NM_005274.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 207bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM834854.1, BC003563.1 and BM809260.1. On or before Aug 31, 2013 this sequence version replaced XM_005270763.1, NM_005274.1. [supplied by OMIM, Nov 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.210159.1, SRR1163655.612147.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGTCTGGCT CCTCCAGCGT CGCCGCTATG AAGAAAGTGG TTCAACAGCT CCGGCTGGAG 
GCCGGACTCA ACCGCGTAAA AGTTTCCCAG GCAGCTGCAG ACTTGAAACA GTTCTGTCTG 
CAGAATGCTC AACATGACCC TCTGCTGACT GGAGTATCTT CAAGTACAAA TCCCTTCAGA 
CCCCAGAAAG TCTGTTCCTT TTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005265.1
CDS	355..561
Translation	MSGSSSVAAMKKVVQQLRLEAGLNRVKVSQAAADLKQFCLQNAQHDPLLTGVSSSTNPFRPQKVCSFL

Target ORF information:

RefSeq Version	NM_005274.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit gamma 5 (GNG5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005274.2

ORF Insert Sequence:

ATGTCTGGCT CCTCCAGCGT CGCCGCTATG AAGAAAGTGG TTCAACAGCT CCGGCTGGAG 
GCCGGACTCA ACCGCGTAAA AGTTTCCCAG GCAGCTGCAG ACTTGAAACA GTTCTGTCTG 
CAGAATGCTC AACATGACCC TCTGCTGACT GGAGTATCTT CAAGTACAAA TCCCTTCAGA 
CCCCAGAAAG TCTGTTCCTT TTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association between single nucleotide polymorphisms of the G-protein ?5 subunit and the risk of essential hypertension in the population of Poland.
Polskie Archiwum Medycyny Wewnetrznej125(12)903-9(2015)
Hejduk P,Sakowicz AM,Miko?ajczyk M,?liwi?ska A,Drzewoski J,Pietrucha T

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
The Journal of cell biology199(6)951-67(2012 Dec)
Ahmed SM,Th?riault BL,Uppalapati M,Chiu CW,Gallie BL,Sidhu SS,Angers S

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

Changes in liver and spleen of normal and allergic rabbits after intraparenchymal injections of serum, and the modifications induced by oral administration of alcohol.
Quarterly journal of studies on alcohol7(3)325-40(1946 Dec)
ROGERS WN

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GNG5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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