GNG3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GNG3
Entrez Gene ID	2785
Full Name	G protein subunit gamma 3
General protein information	Preferred Names G protein subunit gamma 3 Names guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 NBP gamma-3 guanine nucleotide binding protein (G protein), gamma 3 guanine nucleotide-binding protein gamma-3 subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.3
Summary	Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012].
Disorder MIM:	608941

mRNA and Protein(s)

mRNA	Protein	Name
NM_012202.5	NP_036334.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
NM_012202.4	NP_036334.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
XM_006718500.2	XP_006718563.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gng3	NP_034446.1
Xenopus tropicalis (tropical clawed frog)	gng3	NP_001165080.1
Homo sapiens (human)	GNG3	NP_036334.1
Canis lupus familiaris (dog)	GNG3	XP_540904.2
Bos taurus (cattle)	GNG3	NP_776498.1
Rattus norvegicus (Norway rat)	Gng3	NP_446110.1
Pan troglodytes (chimpanzee)	GNG3	XP_001156854.1
Danio rerio (zebrafish)	gng3	NP_571916.1

Gene Ontology
Bibliography

Related articles in PubMed

Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy.
Wagnon JL, Barker BS, Hounshell JA, Haaxma CA, Shealy A, Moss T, Parikh S, Messer RD, Patel MK, Meisler MH
Annals of clinical and translational neurology3(2)114-23(2016 Feb)

Interaction of G-protein ?? complex with chromatin modulates GPCR-dependent gene regulation.
Bhatnagar A, Unal H, Jagannathan R, Kaveti S, Duan ZH, Yong S, Vasanji A, Kinter M, Desnoyer R, Karnik SS
PloS one8(1)e52689(2013)

Regulation of Golgi structure and secretion by receptor-induced G protein ?? complex translocation.
Saini DK, Karunarathne WK, Angaswamy N, Saini D, Cho JH, Kalyanaraman V, Gautam N
Proceedings of the National Academy of Sciences of the United States of America107(25)11417-22(2010 Jun)

Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.
Fowler CE, Aryal P, Suen KF, Slesinger PA
The Journal of physiology580(Pt 1)51-65(2007 Apr)

Mice with deficiency of G protein gamma3 are lean and have seizures.
Schwindinger WF, Giger KE, Betz KS, Stauffer AM, Sunderlin EM, Sim-Selley LJ, Selley DE, Bronson SK, Robishaw JD
Molecular and cellular biology24(17)7758-68(2004 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings suggest a wide-ranging mechanism by which direct interaction of Gbetagamma with specific chromatin bound transcription factors regulates functional gene networks in response to GPCR activation in cells including the angiotensin II type 1 receptor.
Title: Interaction of G-protein ?? complex with chromatin modulates GPCR-dependent gene regulation.

Golgi structure and secretion is regulated by receptor-induced G protein betagamma complex translocation
Title: Regulation of Golgi structure and secretion by receptor-induced G protein ?? complex translocation.

The following GNG3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GNG3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08630	NM_012202.5 Latest version!	Homo sapiens G protein subunit gamma 3 (GNG3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu08630	XM_006718500.2 Latest version!	Homo sapiens G protein subunit gamma 3 (GNG3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu08630	NM_012202.4	Homo sapiens G protein subunit gamma 3 (GNG3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GNG3 ( NM_012202.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_036334.1 Homo sapiens G protein subunit gamma 3 (GNG3), mRNA.

Price & Availability↑

CloneID	OHu08630
Clone ID Related Accession (Same CDS sequence)	NM_012202.5 , NM_012202.4 , XM_006718500.2
Accession Version	NM_012202.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 228bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA123305.1, AP001458.6, AF092129.1 and AF087900.1. On Nov 23, 2018 this sequence version replaced NM_012202.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.192929.1, SRR5189652.193201.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000294117.6/ ENSP00000294117.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAAGGTG AGACCCCGGT GAACAGCACT ATGAGTATTG GGCAAGCACG CAAGATGGTG 
GAACAGCTTA AGATTGAAGC CAGCTTGTGT CGGATAAAGG TGTCCAAGGC AGCAGCAGAC 
CTGATGACTT ACTGTGATGC CCACGCCTGT GAGGATCCCC TCATCACCCC TGTGCCCACT 
TCGGAGAACC CCTTCCGGGA GAAGAAGTTC TTCTGTGCTC TCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036334.1
CDS	242..469
Translation	MKGETPVNSTMSIGQARKMVEQLKIEASLCRIKVSKAAADLMTYCDAHACEDPLITPVPTSENPFREKKFFCALL

Target ORF information:

RefSeq Version	NM_012202.5
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit gamma 3 (GNG3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012202.5

ORF Insert Sequence:

ATGAAAGGTG AGACCCCGGT GAACAGCACT ATGAGTATTG GGCAAGCACG CAAGATGGTG 
GAACAGCTTA AGATTGAAGC CAGCTTGTGT CGGATAAAGG TGTCCAAGGC AGCAGCAGAC 
CTGATGACTT ACTGTGATGC CCACGCCTGT GAGGATCCCC TCATCACCCC TGTGCCCACT 
TCGGAGAACC CCTTCCGGGA GAAGAAGTTC TTCTGTGCTC TCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNG3 ( NM_012202.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036334.1 Homo sapiens G protein subunit gamma 3 (GNG3), mRNA.

Price & Availability↑

CloneID	OHu08630
Clone ID Related Accession (Same CDS sequence)	NM_012202.5 , NM_012202.4 , XM_006718500.2
Accession Version	NM_012202.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 228bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA123305.1, AP001458.6, AF092129.1 and AF087900.1. On Jan 26, 2012 this sequence version replaced NM_012202.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF087900.1, AF092129.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAAGGTG AGACCCCGGT GAACAGCACT ATGAGTATTG GGCAAGCACG CAAGATGGTG 
GAACAGCTTA AGATTGAAGC CAGCTTGTGT CGGATAAAGG TGTCCAAGGC AGCAGCAGAC 
CTGATGACTT ACTGTGATGC CCACGCCTGT GAGGATCCCC TCATCACCCC TGTGCCCACT 
TCGGAGAACC CCTTCCGGGA GAAGAAGTTC TTCTGTGCTC TCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036334.1
CDS	324..551
Translation	MKGETPVNSTMSIGQARKMVEQLKIEASLCRIKVSKAAADLMTYCDAHACEDPLITPVPTSENPFREKKFFCALL

Target ORF information:

RefSeq Version	NM_012202.4
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit gamma 3 (GNG3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012202.4

ORF Insert Sequence:

ATGAAAGGTG AGACCCCGGT GAACAGCACT ATGAGTATTG GGCAAGCACG CAAGATGGTG 
GAACAGCTTA AGATTGAAGC CAGCTTGTGT CGGATAAAGG TGTCCAAGGC AGCAGCAGAC 
CTGATGACTT ACTGTGATGC CCACGCCTGT GAGGATCCCC TCATCACCCC TGTGCCCACT 
TCGGAGAACC CCTTCCGGGA GAAGAAGTTC TTCTGTGCTC TCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNG3 ( XM_006718500.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006718563.1 Homo sapiens G protein subunit gamma 3 (GNG3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu08630
Clone ID Related Accession (Same CDS sequence)	NM_012202.5 , NM_012202.4 , XM_006718500.2
Accession Version	XM_006718500.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 228bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006718500.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAAGGTG AGACCCCGGT GAACAGCACT ATGAGTATTG GGCAAGCACG CAAGATGGTG 
GAACAGCTTA AGATTGAAGC CAGCTTGTGT CGGATAAAGG TGTCCAAGGC AGCAGCAGAC 
CTGATGACTT ACTGTGATGC CCACGCCTGT GAGGATCCCC TCATCACCCC TGTGCCCACT 
TCGGAGAACC CCTTCCGGGA GAAGAAGTTC TTCTGTGCTC TCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006718563.1
CDS	311..538
Translation	MKGETPVNSTMSIGQARKMVEQLKIEASLCRIKVSKAAADLMTYCDAHACEDPLITPVPTSENPFREKKFFCALL

Target ORF information:

RefSeq Version	XM_006718500.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit gamma 3 (GNG3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006718500.2

ORF Insert Sequence:

ATGAAAGGTG AGACCCCGGT GAACAGCACT ATGAGTATTG GGCAAGCACG CAAGATGGTG 
GAACAGCTTA AGATTGAAGC CAGCTTGTGT CGGATAAAGG TGTCCAAGGC AGCAGCAGAC 
CTGATGACTT ACTGTGATGC CCACGCCTGT GAGGATCCCC TCATCACCCC TGTGCCCACT 
TCGGAGAACC CCTTCCGGGA GAAGAAGTTC TTCTGTGCTC TCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy.
Annals of clinical and translational neurology3(2)114-23(2016 Feb)
Wagnon JL,Barker BS,Hounshell JA,Haaxma CA,Shealy A,Moss T,Parikh S,Messer RD,Patel MK,Meisler MH

Interaction of G-protein ?? complex with chromatin modulates GPCR-dependent gene regulation.
PloS one8(1)e52689(2013)
Bhatnagar A,Unal H,Jagannathan R,Kaveti S,Duan ZH,Yong S,Vasanji A,Kinter M,Desnoyer R,Karnik SS

Regulation of Golgi structure and secretion by receptor-induced G protein ?? complex translocation.
Proceedings of the National Academy of Sciences of the United States of America107(25)11417-22(2010 Jun)
Saini DK,Karunarathne WK,Angaswamy N,Saini D,Cho JH,Kalyanaraman V,Gautam N

Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.
The Journal of physiology580(Pt 1)51-65(2007 Apr)
Fowler CE,Aryal P,Suen KF,Slesinger PA

Mice with deficiency of G protein gamma3 are lean and have seizures.
Molecular and cellular biology24(17)7758-68(2004 Sep)
Schwindinger WF,Giger KE,Betz KS,Stauffer AM,Sunderlin EM,Sim-Selley LJ,Selley DE,Bronson SK,Robishaw JD

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GNG3 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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