GLRB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GLRB
Entrez Gene ID	2743
Full Name	glycine receptor beta
Synonyms	HKPX2
General protein information	Preferred Names glycine receptor beta Names glycine receptor subunit beta glycine receptor 58 kDa subunit glycine receptor, beta subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q32.1
Summary	This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
Disorder MIM:	138492
Disorder Html:	Hyperekplexia 2, autosomal recessive, 614619 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017008034.1	XP_016863523.1	glycine receptor subunit beta isoform X1
XM_017008035.1	XP_016863524.1	glycine receptor subunit beta isoform X2
NM_001166061.1	NP_001159533.1	glycine receptor subunit beta isoform B precursor
NM_000824.4	NP_000815.1	glycine receptor subunit beta isoform A precursor
XM_017008035.2	XP_016863524.1	glycine receptor subunit beta isoform X2
NM_001166060.1	NP_001159532.1	glycine receptor subunit beta isoform A precursor
NM_000824.5	NP_000815.1	glycine receptor subunit beta isoform A precursor

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	ort	NP_524406.1
Xenopus tropicalis (tropical clawed frog)	glrb	NP_001072255.1
Homo sapiens (human)	GLRB	NP_000815.1
Pan troglodytes (chimpanzee)	GLRB	XP_517504.1
	GLRB	XP_001093832.1
Bos taurus (cattle)	GLRB	NP_776496.1
Canis lupus familiaris (dog)	GLRB	XP_532701.1
Danio rerio (zebrafish)	glrbb	NP_001003587.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001913	XP_321152.5
Mus musculus (house mouse)	Glrb	NP_034428.2
Rattus norvegicus (Norway rat)	Glrb	NP_445748.1
Gallus gallus (chicken)	GLRB	XP_420379.2
Danio rerio (zebrafish)	glrba	NP_571856.1

Gene Ontology
Bibliography

Related articles in PubMed

GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder.
Deckert J, Weber H, Villmann C, Lonsdorf TB, Richter J, Andreatta M, Arias-Vasquez A, Hommers L, Kent L, Schartner C, Cichon S, Wolf C, Schaefer N, von Collenberg CR, Wachter B, Blum R, Sch?mann D, Scharfenort R, Schumacher J, Forstner AJ, Baumann C, Schiele MA, Notzon S, Zwanzger P, Janzing JGE, Galesloot T, Kiemeney LA, Gajewska A, Glotzbach-Schoon E, M?hlberger A, Alpers G, Fydrich T, Fehm L, Gerlach AL, Kircher T, Lang T, Str?hle A, Arolt V, Wittchen HU, Kalisch R, B?chel C, Hamm A, N?then MM, Romanos M, Domschke K, Pauli P, Reif A
Molecular psychiatry22(10)1431-1439(2017 Oct)

Modulation of defensive reactivity by GLRB allelic variation: converging evidence from an intermediate phenotype approach.
Lueken U, Kuhn M, Yang Y, Straube B, Kircher T, Wittchen HU, Pfleiderer B, Arolt V, Wittmann A, Str?hle A, Weber H, Reif A, Domschke K, Deckert J, Lonsdorf TB
Translational psychiatry7(9)e1227(2017 Sep)

Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbers.
Patrizio A, Renner M, Pizzarelli R, Triller A, Specht CG
Scientific reports7(1)10899(2017 Sep)

[GLYCINE RECEPTOR: MOLECULAR ORGANIZATION AND PATHOLOGY].
Maleeva GV, Bregestovski PD
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)61(5)107-17(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A genome-wide significant association was found between ACQ and single non-coding nucleotide variants of the GLRB gene (rs78726293, P = 3.3 x 10 - 8; rs191260602, P = 3.9 x 10- 8).GLRB gene expression was found to be modulated by rs7688285 in brain tissue, as well as cell culture.
Title: GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder.

Whole-exome sequencing in ASD patients from each family identified a second rare inherited genetic variant, affecting GLRB expressed in inhibitory or in excitatory synapses.
Title: GABA/Glutamate synaptic pathways targeted by integrative genomic and electrophysiological explorations distinguish autism from intellectual disability.

GLRA1 and GLRB mutations are responsible for abnormal startled reactions in humans. (Review)
Title: [GLYCINE RECEPTOR: MOLECULAR ORGANIZATION AND PATHOLOGY].

The N-terminal region of GABRA3 and the GlyR beta subunit occupies the same binding site of gephyrin.
Title: Molecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrin.

p.E375X truncated subunits are incorporated into functional hGlyRs together with unmutated alpha1 or alpha1 plus beta subunits.
Title: New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms.

The following GLRB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GLRB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16432	NM_001166060.1 Latest version!	Homo sapiens glycine receptor beta (GLRB), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu16432	NM_000824.4 Latest version!	Homo sapiens glycine receptor beta (GLRB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu16551	NM_001166061.1 Latest version!	Homo sapiens glycine receptor beta (GLRB), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu57988	XM_017008034.1 Latest version!	Homo sapiens glycine receptor beta (GLRB), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu107606	NM_000824.5 Latest version!	Homo sapiens glycine receptor beta (GLRB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu95067	XM_017008035.2 Latest version!	Homo sapiens glycine receptor beta (GLRB), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu95067	XM_017008035.1	Homo sapiens glycine receptor beta (GLRB), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GLRB ( NM_000824.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000815.1 Homo sapiens glycine receptor beta (GLRB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16432
Clone ID Related Accession (Same CDS sequence)	NM_000824.4 , NM_001166060.1
Accession Version	NM_000824.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1494bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	glycine receptor subunit beta isoform A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA168145.1, BC032635.1, BC022502.1 and CA437106.1. This sequence is a reference standard in the RefSeqGene project. On Oct 6, 2009 this sequence version replaced NM_000824.3. Transcript Variant: This variant (1, also known as variant A) represents the longest transcript and encodes the longer isoform (A). Both variants 1 and 2 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.35429.1, SRR1660805.79916.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGTTTT TATTGACAAC TGCCTTTTTA ATTTTAATTT CCTTGTGGGT GGAAGAAGCC 
TATTCTAAGG AAAAGTCTTC AAAGAAAGGG AAGGGGAAAA AGAAGCAGTA TCTATGCCCA 
TCTCAGCAGT CAGCAGAGGA CCTTGCCCGA GTACCTGCCA ACTCCACTAG CAATATCTTG 
AACAGGTTAT TGGTCAGTTA TGATCCCAGG ATAAGACCAA ACTTCAAAGG CATTCCTGTT 
GATGTAGTAG TCAACATTTT TATTAACAGT TTTGGATCCA TTCAAGAAAC AACAATGGAC 
TATAGAGTTA ACATCTTCCT GAGACAAAAA TGGAATGACC CCAGGCTGAA GCTCCCCAGT 
GATTTTAGGG GTTCAGATGC ACTGACAGTG GATCCAACAA TGTACAAGTG TTTATGGAAA 
CCTGATTTAT TTTTTGCAAA TGAAAAAAGT GCCAATTTTC ATGATGTGAC CCAGGAAAAC 
ATCCTCCTCT TTATTTTTCG TGATGGAGAT GTCCTTGTCA GCATGAGGTT ATCTATTACT 
CTTTCATGCC CTTTGGACTT GACATTGTTT CCCATGGATA CACAACGTTG CAAGATGCAA 
CTGGAGAGCT TTGGTTACAC AACTGATGAT TTACGATTTA TCTGGCAGTC AGGAGATCCT 
GTGCAATTAG AAAAAATTGC CTTGCCTCAA TTTGATATCA AAAAGGAAGA TATTGAATAT 
GGTAACTGTA CAAAATACTA TAAAGGCACG GGCTACTACA CATGCGTGGA AGTCATCTTC 
ACCCTGAGGA GGCAGGTCGG CTTTTACATG ATGGGGGTCT ACGCCCCAAC CCTGCTCATT 
GTTGTTCTCT CCTGGCTTTC CTTCTGGATC AACCCGGACG CGAGTGCTGC CAGAGTGCCC 
CTGGGTATCT TCTCAGTCCT CAGCTTGGCC TCTGAGTGCA CAACCCTTGC CGCTGAGCTT 
CCCAAAGTTT CCTATGTGAA GGCTCTTGAT GTTTGGCTTA TTGCTTGCCT TCTCTTTGGG 
TTTGCTTCCC TGGTGGAGTA TGCAGTTGTC CAGGTGATGC TGAACAACCC CAAAAGGGTT 
GAAGCTGAAA AAGCCAGAAT TGCTAAGGCT GAGCAAGCAG ATGGAAAAGG TGGAAATGTG 
GCTAAAAAGA ATACTGTGAA TGGAACAGGG ACTCCTGTTC ATATTAGCAC TTTGCAGGTT 
GGTGAGACCA GATGCAAAAA AGTTTGTACT TCTAAGTCTG ATCTGAGATC TAATGACTTC 
AGCATTGTTG GAAGCTTACC AAGAGATTTT GAACTATCCA ATTATGACTG CTATGGAAAA 
CCCATTGAAG TTAACAACGG ACTTGGGAAA TCTCAGGCTA AGAACAACAA GAAGCCTCCC 
CCTGCGAAAC CTGTTATTCC AACAGCAGCA AAGCGAATTG ATCTTTATGC AAGAGCATTG 
TTTCCTTTCT GCTTCTTGTT CTTCAATGTT ATATATTGGT CTATATATTT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000815.1
CDS	203..1696
Translation	MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL

Target ORF information:

RefSeq Version	NM_000824.4
Organism	Homo sapiens(human)
Definition	Homo sapiens glycine receptor beta (GLRB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000824.4

ORF Insert Sequence:

ATGAAGTTTT TATTGACAAC TGCCTTTTTA ATTTTAATTT CCTTGTGGGT GGAAGAAGCC 
TATTCTAAGG AAAAGTCTTC AAAGAAAGGG AAGGGGAAAA AGAAGCAGTA TCTATGCCCA 
TCTCAGCAGT CAGCAGAGGA CCTTGCCCGA GTACCTGCCA ACTCCACTAG CAATATCTTG 
AACAGGTTAT TGGTCAGTTA TGATCCCAGG ATAAGACCAA ACTTCAAAGG CATTCCTGTT 
GATGTAGTAG TCAACATTTT TATTAACAGT TTTGGATCCA TTCAAGAAAC AACAATGGAC 
TATAGAGTTA ACATCTTCCT GAGACAAAAA TGGAATGACC CCAGGCTGAA GCTCCCCAGT 
GATTTTAGGG GTTCAGATGC ACTGACAGTG GATCCAACAA TGTACAAGTG TTTATGGAAA 
CCTGATTTAT TTTTTGCAAA TGAAAAAAGT GCCAATTTTC ATGATGTGAC CCAGGAAAAC 
ATCCTCCTCT TTATTTTTCG TGATGGAGAT GTCCTTGTCA GCATGAGGTT ATCTATTACT 
CTTTCATGCC CTTTGGACTT GACATTGTTT CCCATGGATA CACAACGTTG CAAGATGCAA 
CTGGAGAGCT TTGGTTACAC AACTGATGAT TTACGATTTA TCTGGCAGTC AGGAGATCCT 
GTGCAATTAG AAAAAATTGC CTTGCCTCAA TTTGATATCA AAAAGGAAGA TATTGAATAT 
GGTAACTGTA CAAAATACTA TAAAGGCACG GGCTACTACA CATGCGTGGA AGTCATCTTC 
ACCCTGAGGA GGCAGGTCGG CTTTTACATG ATGGGGGTCT ACGCCCCAAC CCTGCTCATT 
GTTGTTCTCT CCTGGCTTTC CTTCTGGATC AACCCGGACG CGAGTGCTGC CAGAGTGCCC 
CTGGGTATCT TCTCAGTCCT CAGCTTGGCC TCTGAGTGCA CAACCCTTGC CGCTGAGCTT 
CCCAAAGTTT CCTATGTGAA GGCTCTTGAT GTTTGGCTTA TTGCTTGCCT TCTCTTTGGG 
TTTGCTTCCC TGGTGGAGTA TGCAGTTGTC CAGGTGATGC TGAACAACCC CAAAAGGGTT 
GAAGCTGAAA AAGCCAGAAT TGCTAAGGCT GAGCAAGCAG ATGGAAAAGG TGGAAATGTG 
GCTAAAAAGA ATACTGTGAA TGGAACAGGG ACTCCTGTTC ATATTAGCAC TTTGCAGGTT 
GGTGAGACCA GATGCAAAAA AGTTTGTACT TCTAAGTCTG ATCTGAGATC TAATGACTTC 
AGCATTGTTG GAAGCTTACC AAGAGATTTT GAACTATCCA ATTATGACTG CTATGGAAAA 
CCCATTGAAG TTAACAACGG ACTTGGGAAA TCTCAGGCTA AGAACAACAA GAAGCCTCCC 
CCTGCGAAAC CTGTTATTCC AACAGCAGCA AAGCGAATTG ATCTTTATGC AAGAGCATTG 
TTTCCTTTCT GCTTCTTGTT CTTCAATGTT ATATATTGGT CTATATATTT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GLRB ( NM_001166060.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001159532.1 Homo sapiens glycine receptor beta (GLRB), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16432
Clone ID Related Accession (Same CDS sequence)	NM_000824.4 , NM_001166060.1
Accession Version	NM_001166060.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1494bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	glycine receptor subunit beta isoform A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB479295.1, AF094755.1, BC032635.1, BC022502.1 and CA437106.1. Transcript Variant: This variant (2, also known as variant B) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (A). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.162685.1, SRR1660809.74093.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGTTTT TATTGACAAC TGCCTTTTTA ATTTTAATTT CCTTGTGGGT GGAAGAAGCC 
TATTCTAAGG AAAAGTCTTC AAAGAAAGGG AAGGGGAAAA AGAAGCAGTA TCTATGCCCA 
TCTCAGCAGT CAGCAGAGGA CCTTGCCCGA GTACCTGCCA ACTCCACTAG CAATATCTTG 
AACAGGTTAT TGGTCAGTTA TGATCCCAGG ATAAGACCAA ACTTCAAAGG CATTCCTGTT 
GATGTAGTAG TCAACATTTT TATTAACAGT TTTGGATCCA TTCAAGAAAC AACAATGGAC 
TATAGAGTTA ACATCTTCCT GAGACAAAAA TGGAATGACC CCAGGCTGAA GCTCCCCAGT 
GATTTTAGGG GTTCAGATGC ACTGACAGTG GATCCAACAA TGTACAAGTG TTTATGGAAA 
CCTGATTTAT TTTTTGCAAA TGAAAAAAGT GCCAATTTTC ATGATGTGAC CCAGGAAAAC 
ATCCTCCTCT TTATTTTTCG TGATGGAGAT GTCCTTGTCA GCATGAGGTT ATCTATTACT 
CTTTCATGCC CTTTGGACTT GACATTGTTT CCCATGGATA CACAACGTTG CAAGATGCAA 
CTGGAGAGCT TTGGTTACAC AACTGATGAT TTACGATTTA TCTGGCAGTC AGGAGATCCT 
GTGCAATTAG AAAAAATTGC CTTGCCTCAA TTTGATATCA AAAAGGAAGA TATTGAATAT 
GGTAACTGTA CAAAATACTA TAAAGGCACG GGCTACTACA CATGCGTGGA AGTCATCTTC 
ACCCTGAGGA GGCAGGTCGG CTTTTACATG ATGGGGGTCT ACGCCCCAAC CCTGCTCATT 
GTTGTTCTCT CCTGGCTTTC CTTCTGGATC AACCCGGACG CGAGTGCTGC CAGAGTGCCC 
CTGGGTATCT TCTCAGTCCT CAGCTTGGCC TCTGAGTGCA CAACCCTTGC CGCTGAGCTT 
CCCAAAGTTT CCTATGTGAA GGCTCTTGAT GTTTGGCTTA TTGCTTGCCT TCTCTTTGGG 
TTTGCTTCCC TGGTGGAGTA TGCAGTTGTC CAGGTGATGC TGAACAACCC CAAAAGGGTT 
GAAGCTGAAA AAGCCAGAAT TGCTAAGGCT GAGCAAGCAG ATGGAAAAGG TGGAAATGTG 
GCTAAAAAGA ATACTGTGAA TGGAACAGGG ACTCCTGTTC ATATTAGCAC TTTGCAGGTT 
GGTGAGACCA GATGCAAAAA AGTTTGTACT TCTAAGTCTG ATCTGAGATC TAATGACTTC 
AGCATTGTTG GAAGCTTACC AAGAGATTTT GAACTATCCA ATTATGACTG CTATGGAAAA 
CCCATTGAAG TTAACAACGG ACTTGGGAAA TCTCAGGCTA AGAACAACAA GAAGCCTCCC 
CCTGCGAAAC CTGTTATTCC AACAGCAGCA AAGCGAATTG ATCTTTATGC AAGAGCATTG 
TTTCCTTTCT GCTTCTTGTT CTTCAATGTT ATATATTGGT CTATATATTT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159532.1
CDS	186..1679
Translation	MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL

Target ORF information:

RefSeq Version	NM_001166060.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glycine receptor beta (GLRB), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166060.1

ORF Insert Sequence:

ATGAAGTTTT TATTGACAAC TGCCTTTTTA ATTTTAATTT CCTTGTGGGT GGAAGAAGCC 
TATTCTAAGG AAAAGTCTTC AAAGAAAGGG AAGGGGAAAA AGAAGCAGTA TCTATGCCCA 
TCTCAGCAGT CAGCAGAGGA CCTTGCCCGA GTACCTGCCA ACTCCACTAG CAATATCTTG 
AACAGGTTAT TGGTCAGTTA TGATCCCAGG ATAAGACCAA ACTTCAAAGG CATTCCTGTT 
GATGTAGTAG TCAACATTTT TATTAACAGT TTTGGATCCA TTCAAGAAAC AACAATGGAC 
TATAGAGTTA ACATCTTCCT GAGACAAAAA TGGAATGACC CCAGGCTGAA GCTCCCCAGT 
GATTTTAGGG GTTCAGATGC ACTGACAGTG GATCCAACAA TGTACAAGTG TTTATGGAAA 
CCTGATTTAT TTTTTGCAAA TGAAAAAAGT GCCAATTTTC ATGATGTGAC CCAGGAAAAC 
ATCCTCCTCT TTATTTTTCG TGATGGAGAT GTCCTTGTCA GCATGAGGTT ATCTATTACT 
CTTTCATGCC CTTTGGACTT GACATTGTTT CCCATGGATA CACAACGTTG CAAGATGCAA 
CTGGAGAGCT TTGGTTACAC AACTGATGAT TTACGATTTA TCTGGCAGTC AGGAGATCCT 
GTGCAATTAG AAAAAATTGC CTTGCCTCAA TTTGATATCA AAAAGGAAGA TATTGAATAT 
GGTAACTGTA CAAAATACTA TAAAGGCACG GGCTACTACA CATGCGTGGA AGTCATCTTC 
ACCCTGAGGA GGCAGGTCGG CTTTTACATG ATGGGGGTCT ACGCCCCAAC CCTGCTCATT 
GTTGTTCTCT CCTGGCTTTC CTTCTGGATC AACCCGGACG CGAGTGCTGC CAGAGTGCCC 
CTGGGTATCT TCTCAGTCCT CAGCTTGGCC TCTGAGTGCA CAACCCTTGC CGCTGAGCTT 
CCCAAAGTTT CCTATGTGAA GGCTCTTGAT GTTTGGCTTA TTGCTTGCCT TCTCTTTGGG 
TTTGCTTCCC TGGTGGAGTA TGCAGTTGTC CAGGTGATGC TGAACAACCC CAAAAGGGTT 
GAAGCTGAAA AAGCCAGAAT TGCTAAGGCT GAGCAAGCAG ATGGAAAAGG TGGAAATGTG 
GCTAAAAAGA ATACTGTGAA TGGAACAGGG ACTCCTGTTC ATATTAGCAC TTTGCAGGTT 
GGTGAGACCA GATGCAAAAA AGTTTGTACT TCTAAGTCTG ATCTGAGATC TAATGACTTC 
AGCATTGTTG GAAGCTTACC AAGAGATTTT GAACTATCCA ATTATGACTG CTATGGAAAA 
CCCATTGAAG TTAACAACGG ACTTGGGAAA TCTCAGGCTA AGAACAACAA GAAGCCTCCC 
CCTGCGAAAC CTGTTATTCC AACAGCAGCA AAGCGAATTG ATCTTTATGC AAGAGCATTG 
TTTCCTTTCT GCTTCTTGTT CTTCAATGTT ATATATTGGT CTATATATTT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GLRB ( NM_001166061.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001159533.1 Homo sapiens glycine receptor beta (GLRB), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu16551
Clone ID Related Accession (Same CDS sequence)	NM_001166061.1
Accession Version	NM_001166061.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	glycine receptor subunit beta isoform B precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA168145.1, CD013911.1, BC032635.1, BC022502.1 and CA437106.1. Transcript Variant: This variant (3, also known as GlyR beta delta8) lacks an alternate internal exon that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (B) has a distinct C-terminus and is shorter than isoform A. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.33915.1, SRR1660809.111767.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGTTTT TATTGACAAC TGCCTTTTTA ATTTTAATTT CCTTGTGGGT GGAAGAAGCC 
TATTCTAAGG AAAAGTCTTC AAAGAAAGGG AAGGGGAAAA AGAAGCAGTA TCTATGCCCA 
TCTCAGCAGT CAGCAGAGGA CCTTGCCCGA GTACCTGCCA ACTCCACTAG CAATATCTTG 
AACAGGTTAT TGGTCAGTTA TGATCCCAGG ATAAGACCAA ACTTCAAAGG CATTCCTGTT 
GATGTAGTAG TCAACATTTT TATTAACAGT TTTGGATCCA TTCAAGAAAC AACAATGGAC 
TATAGAGTTA ACATCTTCCT GAGACAAAAA TGGAATGACC CCAGGCTGAA GCTCCCCAGT 
GATTTTAGGG GTTCAGATGC ACTGACAGTG GATCCAACAA TGTACAAGTG TTTATGGAAA 
CCTGATTTAT TTTTTGCAAA TGAAAAAAGT GCCAATTTTC ATGATGTGAC CCAGGAAAAC 
ATCCTCCTCT TTATTTTTCG TGATGGAGAT GTCCTTGTCA GCATGAGGTT ATCTATTACT 
CTTTCATGCC CTTTGGACTT GACATTGTTT CCCATGGATA CACAACGTTG CAAGATGCAA 
CTGGAGAGCT TTGGTTACAC AACTGATGAT TTACGATTTA TCTGGCAGTC AGGAGATCCT 
GTGCAATTAG AAAAAATTGC CTTGCCTCAA TTTGATATCA AAAAGGAAGA TATTGAATAT 
GGTAACTGTA CAAAATACTA TAAAGGCACG GGCTACTACA CATGCGTGGA AGTCATCTTC 
ACCCTGAGGA GGCAGGTCGG CTTTTACATG ATGGGGGTCT ACGCCCCAAC CCTGCTCATT 
GTTGTTCTCT CCTGGCTTTC CTTCTGGATC AACCCGGACG CGAGTGCTGC CAGAGTGCCC 
CTGGGTTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159533.1
CDS	203..1114
Translation	MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGW

Target ORF information:

RefSeq Version	NM_001166061.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glycine receptor beta (GLRB), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166061.1

ORF Insert Sequence:

ATGAAGTTTT TATTGACAAC TGCCTTTTTA ATTTTAATTT CCTTGTGGGT GGAAGAAGCC 
TATTCTAAGG AAAAGTCTTC AAAGAAAGGG AAGGGGAAAA AGAAGCAGTA TCTATGCCCA 
TCTCAGCAGT CAGCAGAGGA CCTTGCCCGA GTACCTGCCA ACTCCACTAG CAATATCTTG 
AACAGGTTAT TGGTCAGTTA TGATCCCAGG ATAAGACCAA ACTTCAAAGG CATTCCTGTT 
GATGTAGTAG TCAACATTTT TATTAACAGT TTTGGATCCA TTCAAGAAAC AACAATGGAC 
TATAGAGTTA ACATCTTCCT GAGACAAAAA TGGAATGACC CCAGGCTGAA GCTCCCCAGT 
GATTTTAGGG GTTCAGATGC ACTGACAGTG GATCCAACAA TGTACAAGTG TTTATGGAAA 
CCTGATTTAT TTTTTGCAAA TGAAAAAAGT GCCAATTTTC ATGATGTGAC CCAGGAAAAC 
ATCCTCCTCT TTATTTTTCG TGATGGAGAT GTCCTTGTCA GCATGAGGTT ATCTATTACT 
CTTTCATGCC CTTTGGACTT GACATTGTTT CCCATGGATA CACAACGTTG CAAGATGCAA 
CTGGAGAGCT TTGGTTACAC AACTGATGAT TTACGATTTA TCTGGCAGTC AGGAGATCCT 
GTGCAATTAG AAAAAATTGC CTTGCCTCAA TTTGATATCA AAAAGGAAGA TATTGAATAT 
GGTAACTGTA CAAAATACTA TAAAGGCACG GGCTACTACA CATGCGTGGA AGTCATCTTC 
ACCCTGAGGA GGCAGGTCGG CTTTTACATG ATGGGGGTCT ACGCCCCAAC CCTGCTCATT 
GTTGTTCTCT CCTGGCTTTC CTTCTGGATC AACCCGGACG CGAGTGCTGC CAGAGTGCCC 
CTGGGTTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GLRB ( XM_017008034.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016863523.1 Homo sapiens glycine receptor beta (GLRB), transcript variant X1, mRNA.

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CloneID	OHu57988
Clone ID Related Accession (Same CDS sequence)	XM_017008034.1
Accession Version	XM_017008034.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	glycine receptor subunit beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACTATA GAGTTAACAT CTTCCTGAGA CAAAAATGGA ATGACCCCAG GCTGAAGCTC 
CCCAGTGATT TTAGGGGTTC AGATGCACTG ACAGTGGATC CAACAATGTA CAAGTGTTTA 
TGGAAACCTG ATTTATTTTT TGCAAATGAA AAAAGTGCCA ATTTTCATGA TGTGACCCAG 
GAAAACATCC TCCTCTTTAT TTTTCGTGAT GGAGATGTCC TTGTCAGCAT GAGGTTATCT 
ATTACTCTTT CATGCCCTTT GGACTTGACA TTGTTTCCCA TGGATACACA ACGTTGCAAG 
ATGCAACTGG AGAGCTTTGG TTACACAACT GATGATTTAC GATTTATCTG GCAGTCAGGA 
GATCCTGTGC AATTAGAAAA AATTGCCTTG CCTCAATTTG ATATCAAAAA GGAAGATATT 
GAATATGGTA ACTGTACAAA ATACTATAAA GGCACGGGCT ACTACACATG CGTGGAAGTC 
ATCTTCACCC TGAGGAGGCA GGTCGGCTTT TACATGATGG GGGTCTACGC CCCAACTCTG 
CTCATTGTTG TTCTCTCCTG GCTTTCCTTC TGGATCAACC CGGACGCGAG TGCTGCCAGA 
GTGCCCCTGG GTATCTTCTC AGTCCTCAGC TTGGCCTCTG AGTGCACAAC CCTTGCCGCT 
GAGCTTCCCA AAGTTTCCTA TGTGAAGGCT CTTGATGTTT GGCTTATTGC TTGCCTTCTC 
TTTGGGTTTG CTTCCCTGGT GGAGTATGCA GTTGTCCAGG TGATGCTGAA CAACCCCAAA 
AGGGTTGAAG CTGAAAAAGC CAGAATTGCT AAGGCTGAGC AAGCAGATGG AAAAGGTGGA 
AATGTGGCTA AAAAGAATAC TGTGAATGGA ACAGGGACTC CTGTTCATAT TAGCACTTTG 
CAGGTTGGTG AGACCAGATG CAAAAAAGTT TGTACTTCTA AGTCTGATCT GAGATCTAAT 
GACTTCAGCA TTGTTGGAAG CTTACCAAGA GATTTTGAAC TATCCAATTA TGACTGCTAT 
GGAAAACCCA TTGAAGTTAA CAACGGACTT GGGAAATCTC AGGCTAAGAA CAACAAGAAG 
CCTCCCCCTG CGAAACCTGT TATTCCAACA GCAGCAAAGC GAATTGATCT TTATGCAAGA 
GCATTGTTTC CTTTCTGCTT CTTGTTCTTC AATGTTATAT ATTGGTCTAT ATATTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016863523.1
CDS	291..1490
Translation	MDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL

Target ORF information:

RefSeq Version	XM_017008034.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glycine receptor beta (GLRB), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017008034.1

ORF Insert Sequence:

ATGGACTATA GAGTTAACAT CTTCCTGAGA CAAAAATGGA ATGACCCCAG GCTGAAGCTC 
CCCAGTGATT TTAGGGGTTC AGATGCACTG ACAGTGGATC CAACAATGTA CAAGTGTTTA 
TGGAAACCTG ATTTATTTTT TGCAAATGAA AAAAGTGCCA ATTTTCATGA TGTGACCCAG 
GAAAACATCC TCCTCTTTAT TTTTCGTGAT GGAGATGTCC TTGTCAGCAT GAGGTTATCT 
ATTACTCTTT CATGCCCTTT GGACTTGACA TTGTTTCCCA TGGATACACA ACGTTGCAAG 
ATGCAACTGG AGAGCTTTGG TTACACAACT GATGATTTAC GATTTATCTG GCAGTCAGGA 
GATCCTGTGC AATTAGAAAA AATTGCCTTG CCTCAATTTG ATATCAAAAA GGAAGATATT 
GAATATGGTA ACTGTACAAA ATACTATAAA GGCACGGGCT ACTACACATG CGTGGAAGTC 
ATCTTCACCC TGAGGAGGCA GGTCGGCTTT TACATGATGG GGGTCTACGC CCCAACTCTG 
CTCATTGTTG TTCTCTCCTG GCTTTCCTTC TGGATCAACC CGGACGCGAG TGCTGCCAGA 
GTGCCCCTGG GTATCTTCTC AGTCCTCAGC TTGGCCTCTG AGTGCACAAC CCTTGCCGCT 
GAGCTTCCCA AAGTTTCCTA TGTGAAGGCT CTTGATGTTT GGCTTATTGC TTGCCTTCTC 
TTTGGGTTTG CTTCCCTGGT GGAGTATGCA GTTGTCCAGG TGATGCTGAA CAACCCCAAA 
AGGGTTGAAG CTGAAAAAGC CAGAATTGCT AAGGCTGAGC AAGCAGATGG AAAAGGTGGA 
AATGTGGCTA AAAAGAATAC TGTGAATGGA ACAGGGACTC CTGTTCATAT TAGCACTTTG 
CAGGTTGGTG AGACCAGATG CAAAAAAGTT TGTACTTCTA AGTCTGATCT GAGATCTAAT 
GACTTCAGCA TTGTTGGAAG CTTACCAAGA GATTTTGAAC TATCCAATTA TGACTGCTAT 
GGAAAACCCA TTGAAGTTAA CAACGGACTT GGGAAATCTC AGGCTAAGAA CAACAAGAAG 
CCTCCCCCTG CGAAACCTGT TATTCCAACA GCAGCAAAGC GAATTGATCT TTATGCAAGA 
GCATTGTTTC CTTTCTGCTT CTTGTTCTTC AATGTTATAT ATTGGTCTAT ATATTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GLRB ( NM_000824.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000815.1 Homo sapiens glycine receptor beta (GLRB), transcript variant 1, mRNA.

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CloneID	OHu107606
Clone ID Related Accession (Same CDS sequence)	NM_000824.5
Accession Version	NM_000824.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1494bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	glycine receptor subunit beta isoform A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC079403.3. On Nov 22, 2018 this sequence version replaced NM_000824.4. Transcript Variant: This variant (1, also known as variant A) represents the longest transcript and encodes the longer isoform (A). Both variants 1 and 2 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.106379.1, SRR1660807.35429.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000264428.9/ ENSP00000264428.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGTTTT TATTGACAAC TGCCTTTTTA ATTTTAATTT CCTTGTGGGT GGAAGAAGCC 
TATTCTAAGG AAAAGTCTTC AAAGAAAGGG AAGGGGAAAA AGAAGCAGTA TCTATGCCCA 
TCTCAGCAGT CAGCAGAGGA CCTTGCCCGA GTACCTGCCA ACTCCACTAG CAATATCTTG 
AACAGGTTAT TGGTCAGTTA TGATCCCAGG ATAAGACCAA ACTTCAAAGG CATTCCTGTT 
GATGTAGTAG TCAACATTTT TATTAACAGT TTTGGATCCA TTCAAGAAAC AACAATGGAC 
TATAGAGTTA ACATCTTCCT GAGACAAAAA TGGAATGACC CCAGGCTGAA GCTCCCCAGT 
GATTTTAGGG GTTCAGATGC ACTGACAGTG GATCCAACAA TGTACAAGTG TTTATGGAAA 
CCTGATTTAT TTTTTGCAAA TGAAAAAAGT GCCAATTTTC ATGATGTGAC CCAGGAAAAC 
ATCCTCCTCT TTATTTTTCG TGATGGAGAT GTCCTTGTCA GCATGAGGTT ATCTATTACT 
CTTTCATGCC CTTTGGACTT GACATTGTTT CCCATGGATA CACAACGTTG CAAGATGCAA 
CTGGAGAGCT TTGGTTACAC AACTGATGAT TTACGATTTA TCTGGCAGTC AGGAGATCCT 
GTGCAATTAG AAAAAATTGC CTTGCCTCAA TTTGATATCA AAAAGGAAGA TATTGAATAT 
GGTAACTGTA CAAAATACTA TAAAGGCACG GGCTACTACA CATGCGTGGA AGTCATCTTC 
ACCCTGAGGA GGCAGGTCGG CTTTTACATG ATGGGGGTCT ACGCCCCAAC TCTGCTCATT 
GTTGTTCTCT CCTGGCTTTC CTTCTGGATC AACCCGGACG CGAGTGCTGC CAGAGTGCCC 
CTGGGTATCT TCTCAGTCCT CAGCTTGGCC TCTGAGTGCA CAACCCTTGC CGCTGAGCTT 
CCCAAAGTTT CCTATGTGAA GGCTCTTGAT GTTTGGCTTA TTGCTTGCCT TCTCTTTGGG 
TTTGCTTCCC TGGTGGAGTA TGCAGTTGTC CAGGTGATGC TGAACAACCC CAAAAGGGTT 
GAAGCTGAAA AAGCCAGAAT TGCTAAGGCT GAGCAAGCAG ATGGAAAAGG TGGAAATGTG 
GCTAAAAAGA ATACTGTGAA TGGAACAGGG ACTCCTGTTC ATATTAGCAC TTTGCAGGTT 
GGTGAGACCA GATGCAAAAA AGTTTGTACT TCTAAGTCTG ATCTGAGATC TAATGACTTC 
AGCATTGTTG GAAGCTTACC AAGAGATTTT GAACTATCCA ATTATGACTG CTATGGAAAA 
CCCATTGAAG TTAACAACGG ACTTGGGAAA TCTCAGGCTA AGAACAACAA GAAGCCTCCC 
CCTGCGAAAC CTGTTATTCC AACAGCAGCA AAGCGAATTG ATCTTTATGC AAGAGCATTG 
TTTCCTTTCT GCTTCTTGTT CTTCAATGTT ATATATTGGT CTATATATTT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000815.1
CDS	178..1671
Translation	MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL

Target ORF information:

RefSeq Version	NM_000824.5
Organism	Homo sapiens(human)
Definition	Homo sapiens glycine receptor beta (GLRB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000824.5

ORF Insert Sequence:

ATGAAGTTTT TATTGACAAC TGCCTTTTTA ATTTTAATTT CCTTGTGGGT GGAAGAAGCC 
TATTCTAAGG AAAAGTCTTC AAAGAAAGGG AAGGGGAAAA AGAAGCAGTA TCTATGCCCA 
TCTCAGCAGT CAGCAGAGGA CCTTGCCCGA GTACCTGCCA ACTCCACTAG CAATATCTTG 
AACAGGTTAT TGGTCAGTTA TGATCCCAGG ATAAGACCAA ACTTCAAAGG CATTCCTGTT 
GATGTAGTAG TCAACATTTT TATTAACAGT TTTGGATCCA TTCAAGAAAC AACAATGGAC 
TATAGAGTTA ACATCTTCCT GAGACAAAAA TGGAATGACC CCAGGCTGAA GCTCCCCAGT 
GATTTTAGGG GTTCAGATGC ACTGACAGTG GATCCAACAA TGTACAAGTG TTTATGGAAA 
CCTGATTTAT TTTTTGCAAA TGAAAAAAGT GCCAATTTTC ATGATGTGAC CCAGGAAAAC 
ATCCTCCTCT TTATTTTTCG TGATGGAGAT GTCCTTGTCA GCATGAGGTT ATCTATTACT 
CTTTCATGCC CTTTGGACTT GACATTGTTT CCCATGGATA CACAACGTTG CAAGATGCAA 
CTGGAGAGCT TTGGTTACAC AACTGATGAT TTACGATTTA TCTGGCAGTC AGGAGATCCT 
GTGCAATTAG AAAAAATTGC CTTGCCTCAA TTTGATATCA AAAAGGAAGA TATTGAATAT 
GGTAACTGTA CAAAATACTA TAAAGGCACG GGCTACTACA CATGCGTGGA AGTCATCTTC 
ACCCTGAGGA GGCAGGTCGG CTTTTACATG ATGGGGGTCT ACGCCCCAAC TCTGCTCATT 
GTTGTTCTCT CCTGGCTTTC CTTCTGGATC AACCCGGACG CGAGTGCTGC CAGAGTGCCC 
CTGGGTATCT TCTCAGTCCT CAGCTTGGCC TCTGAGTGCA CAACCCTTGC CGCTGAGCTT 
CCCAAAGTTT CCTATGTGAA GGCTCTTGAT GTTTGGCTTA TTGCTTGCCT TCTCTTTGGG 
TTTGCTTCCC TGGTGGAGTA TGCAGTTGTC CAGGTGATGC TGAACAACCC CAAAAGGGTT 
GAAGCTGAAA AAGCCAGAAT TGCTAAGGCT GAGCAAGCAG ATGGAAAAGG TGGAAATGTG 
GCTAAAAAGA ATACTGTGAA TGGAACAGGG ACTCCTGTTC ATATTAGCAC TTTGCAGGTT 
GGTGAGACCA GATGCAAAAA AGTTTGTACT TCTAAGTCTG ATCTGAGATC TAATGACTTC 
AGCATTGTTG GAAGCTTACC AAGAGATTTT GAACTATCCA ATTATGACTG CTATGGAAAA 
CCCATTGAAG TTAACAACGG ACTTGGGAAA TCTCAGGCTA AGAACAACAA GAAGCCTCCC 
CCTGCGAAAC CTGTTATTCC AACAGCAGCA AAGCGAATTG ATCTTTATGC AAGAGCATTG 
TTTCCTTTCT GCTTCTTGTT CTTCAATGTT ATATATTGGT CTATATATTT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GLRB ( XM_017008035.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016863524.1 Homo sapiens glycine receptor beta (GLRB), transcript variant X3, mRNA.

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CloneID	OHu95067
Clone ID Related Accession (Same CDS sequence)	XM_017008035.1 , XM_017008035.2
Accession Version	XM_017008035.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	glycine receptor subunit beta isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGTTTT TATTGACAAC TGCCTTTTTA ATTTTAATTT CCTTGTGGGT GGAAGAAGCC 
TATTCTAAGG AAAAGTCTTC AAAGAAAGGG AAGGGGAAAA AGAAGCAGTA TCTATGCCCA 
TCTCAGCAGT CAGCAGAGGA CCTTGCCCGA GTACCTGCCA ACTCCACTAG CAATATCTTG 
AACAGGTTAT TGGTCAGTTA TGATCCCAGG ATAAGACCAA ACTTCAAAGG CATTCCTGTT 
GATGTAGTAG TCAACATTTT TATTAACAGT TTTGGATCCA TTCAAGAAAC AACAATGGAC 
TATAGAGTTA ACATCTTCCT GAGACAAAAA TGGAATGACC CCAGGCTGAA GCTCCCCAGT 
GATTTTAGGG GTTCAGATGC ACTGACAGTG GATCCAACAA TGTACAAGTG TTTATGGAAA 
CCTGATTTAT TTTTTGCAAA TGAAAAAAGT GCCAATTTTC ATGATGTGAC CCAGGAAAAC 
ATCCTCCTCT TTATTTTTCG TGATGGAGAT GTCCTTGTCA GCATGAGGTT ATCTATTACT 
CTTTCATGCC CTTTGGACTT GACATTGTTT CCCATGGATA CACAACGTTG CAAGATGCAA 
CTGGAGAGCT TTGGTTACAC AACTGATGAT TTACGATTTA TCTGGCAGTC AGGAGATCCT 
GTGCAATTAG AAAAAATTGC CTTGCCTCAA TTTGATATCA AAAAGGAAGA TATTGAATAT 
GGTAACTGTA CAAAATACTA TAAAGGCACG GGCTACTACA CATGCGTGGA AGTCATCTTC 
ACCCTGAGGA GGCAGGTCGG CTTTTACATG ATGGGGGTCT ACGCCCCAAC TCTGCTCATT 
GTTGTTCTCT CCTGGCTTTC CTTCTGGATC AACCCGGACG CGAGTGCTGC CAGAGTGCCC 
CTGGGTTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016863524.1
CDS	180..1091
Translation	MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGW

Target ORF information:

RefSeq Version	XM_017008035.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glycine receptor beta (GLRB), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017008035.1

ORF Insert Sequence:

ATGAAGTTTT TATTGACAAC TGCCTTTTTA ATTTTAATTT CCTTGTGGGT GGAAGAAGCC 
TATTCTAAGG AAAAGTCTTC AAAGAAAGGG AAGGGGAAAA AGAAGCAGTA TCTATGCCCA 
TCTCAGCAGT CAGCAGAGGA CCTTGCCCGA GTACCTGCCA ACTCCACTAG CAATATCTTG 
AACAGGTTAT TGGTCAGTTA TGATCCCAGG ATAAGACCAA ACTTCAAAGG CATTCCTGTT 
GATGTAGTAG TCAACATTTT TATTAACAGT TTTGGATCCA TTCAAGAAAC AACAATGGAC 
TATAGAGTTA ACATCTTCCT GAGACAAAAA TGGAATGACC CCAGGCTGAA GCTCCCCAGT 
GATTTTAGGG GTTCAGATGC ACTGACAGTG GATCCAACAA TGTACAAGTG TTTATGGAAA 
CCTGATTTAT TTTTTGCAAA TGAAAAAAGT GCCAATTTTC ATGATGTGAC CCAGGAAAAC 
ATCCTCCTCT TTATTTTTCG TGATGGAGAT GTCCTTGTCA GCATGAGGTT ATCTATTACT 
CTTTCATGCC CTTTGGACTT GACATTGTTT CCCATGGATA CACAACGTTG CAAGATGCAA 
CTGGAGAGCT TTGGTTACAC AACTGATGAT TTACGATTTA TCTGGCAGTC AGGAGATCCT 
GTGCAATTAG AAAAAATTGC CTTGCCTCAA TTTGATATCA AAAAGGAAGA TATTGAATAT 
GGTAACTGTA CAAAATACTA TAAAGGCACG GGCTACTACA CATGCGTGGA AGTCATCTTC 
ACCCTGAGGA GGCAGGTCGG CTTTTACATG ATGGGGGTCT ACGCCCCAAC TCTGCTCATT 
GTTGTTCTCT CCTGGCTTTC CTTCTGGATC AACCCGGACG CGAGTGCTGC CAGAGTGCCC 
CTGGGTTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GLRB ( XM_017008035.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016863524.1 Homo sapiens glycine receptor beta (GLRB), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu95067
Clone ID Related Accession (Same CDS sequence)	XM_017008035.1 , XM_017008035.2
Accession Version	XM_017008035.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	glycine receptor subunit beta isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017008035.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGTTTT TATTGACAAC TGCCTTTTTA ATTTTAATTT CCTTGTGGGT GGAAGAAGCC 
TATTCTAAGG AAAAGTCTTC AAAGAAAGGG AAGGGGAAAA AGAAGCAGTA TCTATGCCCA 
TCTCAGCAGT CAGCAGAGGA CCTTGCCCGA GTACCTGCCA ACTCCACTAG CAATATCTTG 
AACAGGTTAT TGGTCAGTTA TGATCCCAGG ATAAGACCAA ACTTCAAAGG CATTCCTGTT 
GATGTAGTAG TCAACATTTT TATTAACAGT TTTGGATCCA TTCAAGAAAC AACAATGGAC 
TATAGAGTTA ACATCTTCCT GAGACAAAAA TGGAATGACC CCAGGCTGAA GCTCCCCAGT 
GATTTTAGGG GTTCAGATGC ACTGACAGTG GATCCAACAA TGTACAAGTG TTTATGGAAA 
CCTGATTTAT TTTTTGCAAA TGAAAAAAGT GCCAATTTTC ATGATGTGAC CCAGGAAAAC 
ATCCTCCTCT TTATTTTTCG TGATGGAGAT GTCCTTGTCA GCATGAGGTT ATCTATTACT 
CTTTCATGCC CTTTGGACTT GACATTGTTT CCCATGGATA CACAACGTTG CAAGATGCAA 
CTGGAGAGCT TTGGTTACAC AACTGATGAT TTACGATTTA TCTGGCAGTC AGGAGATCCT 
GTGCAATTAG AAAAAATTGC CTTGCCTCAA TTTGATATCA AAAAGGAAGA TATTGAATAT 
GGTAACTGTA CAAAATACTA TAAAGGCACG GGCTACTACA CATGCGTGGA AGTCATCTTC 
ACCCTGAGGA GGCAGGTCGG CTTTTACATG ATGGGGGTCT ACGCCCCAAC TCTGCTCATT 
GTTGTTCTCT CCTGGCTTTC CTTCTGGATC AACCCGGACG CGAGTGCTGC CAGAGTGCCC 
CTGGGTTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016863524.1
CDS	155..1066
Translation	MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGW

Target ORF information:

RefSeq Version	XM_017008035.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glycine receptor beta (GLRB), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017008035.2

ORF Insert Sequence:

ATGAAGTTTT TATTGACAAC TGCCTTTTTA ATTTTAATTT CCTTGTGGGT GGAAGAAGCC 
TATTCTAAGG AAAAGTCTTC AAAGAAAGGG AAGGGGAAAA AGAAGCAGTA TCTATGCCCA 
TCTCAGCAGT CAGCAGAGGA CCTTGCCCGA GTACCTGCCA ACTCCACTAG CAATATCTTG 
AACAGGTTAT TGGTCAGTTA TGATCCCAGG ATAAGACCAA ACTTCAAAGG CATTCCTGTT 
GATGTAGTAG TCAACATTTT TATTAACAGT TTTGGATCCA TTCAAGAAAC AACAATGGAC 
TATAGAGTTA ACATCTTCCT GAGACAAAAA TGGAATGACC CCAGGCTGAA GCTCCCCAGT 
GATTTTAGGG GTTCAGATGC ACTGACAGTG GATCCAACAA TGTACAAGTG TTTATGGAAA 
CCTGATTTAT TTTTTGCAAA TGAAAAAAGT GCCAATTTTC ATGATGTGAC CCAGGAAAAC 
ATCCTCCTCT TTATTTTTCG TGATGGAGAT GTCCTTGTCA GCATGAGGTT ATCTATTACT 
CTTTCATGCC CTTTGGACTT GACATTGTTT CCCATGGATA CACAACGTTG CAAGATGCAA 
CTGGAGAGCT TTGGTTACAC AACTGATGAT TTACGATTTA TCTGGCAGTC AGGAGATCCT 
GTGCAATTAG AAAAAATTGC CTTGCCTCAA TTTGATATCA AAAAGGAAGA TATTGAATAT 
GGTAACTGTA CAAAATACTA TAAAGGCACG GGCTACTACA CATGCGTGGA AGTCATCTTC 
ACCCTGAGGA GGCAGGTCGG CTTTTACATG ATGGGGGTCT ACGCCCCAAC TCTGCTCATT 
GTTGTTCTCT CCTGGCTTTC CTTCTGGATC AACCCGGACG CGAGTGCTGC CAGAGTGCCC 
CTGGGTTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder.
Molecular psychiatry22(10)1431-1439(2017 Oct)
Deckert J,Weber H,Villmann C,Lonsdorf TB,Richter J,Andreatta M,Arias-Vasquez A,Hommers L,Kent L,Schartner C,Cichon S,Wolf C,Schaefer N,von Collenberg CR,Wachter B,Blum R,Sch?mann D,Scharfenort R,Schumacher J,Forstner AJ,Baumann C,Schiele MA,Notzon S,Zwanzger P,Janzing JGE,Galesloot T,Kiemeney LA,Gajewska A,Glotzbach-Schoon E,M?hlberger A,Alpers G,Fydrich T,Fehm L,Gerlach AL,Kircher T,Lang T,Str?hle A,Arolt V,Wittchen HU,Kalisch R,B?chel C,Hamm A,N?then MM,Romanos M,Domschke K,Pauli P,Reif A

Modulation of defensive reactivity by GLRB allelic variation: converging evidence from an intermediate phenotype approach.
Translational psychiatry7(9)e1227(2017 Sep)
Lueken U,Kuhn M,Yang Y,Straube B,Kircher T,Wittchen HU,Pfleiderer B,Arolt V,Wittmann A,Str?hle A,Weber H,Reif A,Domschke K,Deckert J,Lonsdorf TB

Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbers.
Scientific reports7(1)10899(2017 Sep)
Patrizio A,Renner M,Pizzarelli R,Triller A,Specht CG

[GLYCINE RECEPTOR: MOLECULAR ORGANIZATION AND PATHOLOGY].
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)61(5)107-17(2015)
Maleeva GV,Bregestovski PD

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GLRB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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