Gene Symbol | GCLM |
Entrez Gene ID | 2730 |
Full Name | glutamate-cysteine ligase modifier subunit |
Synonyms | GLCLR |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. |
Disorder MIM: | |
Disorder Html: | {Myocardial infarction, susceptibility to}, 608446 (3) |