VPS41 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VPS41
Entrez Gene ID	27072
Full Name	VPS41, HOPS complex subunit
Synonyms	HVPS41,HVSP41,hVps41p
General protein information	Preferred Names VPS41, HOPS complex subunit Names vacuolar protein sorting-associated protein 41 homolog S53 vacuolar assembly protein 41 vacuolar protein sorting 41 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p14.1
Summary	Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. [provided by RefSeq, Jul 2008].
Disorder MIM:	605485

mRNA and Protein(s)

mRNA	Protein	Name
NM_014396.4	NP_055211.2	vacuolar protein sorting-associated protein 41 homolog isoform 1
NM_080631.3	NP_542198.2	vacuolar protein sorting-associated protein 41 homolog isoform 2
XM_017011988.1	XP_016867477.1	vacuolar protein sorting-associated protein 41 homolog isoform X1
NM_014396.3	NP_055211.2	vacuolar protein sorting-associated protein 41 homolog isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	VPS41	XP_533084.2
Mus musculus (house mouse)	Vps41	NP_742118.3
Oryza sativa (rice)	Os04g0195000	NP_001052213.1
Xenopus tropicalis (tropical clawed frog)	vps41	XP_004912577.1
Pan troglodytes (chimpanzee)	VPS41	XP_519057.3
	VPS41	XP_001101460.2
Rattus norvegicus (Norway rat)	Vps41	NP_001100825.1
Drosophila melanogaster (fruit fly)	lt	NP_001260695.1
Homo sapiens (human)	VPS41	NP_055211.2
Danio rerio (zebrafish)	vps41	XP_691671.2
Bos taurus (cattle)	VPS41	NP_001076922.1
Gallus gallus (chicken)	VPS41	NP_001012877.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009174	XP_319939.4
Arabidopsis thaliana (thale cress)	VPS41	NP_172297.2

Gene Ontology
Bibliography

Related articles in PubMed

VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction.
Hunter MR, Scourfield EJ, Emmott E, Graham SC
The Biochemical journal474(21)3615-3626(2017 10)

Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.
van der Kant R, Jonker CT, Wijdeven RH, Bakker J, Janssen L, Klumperman J, Neefjes J
The Journal of biological chemistry290(51)30280-90(2015 Dec)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.
Wartosch L, G?nesdogan U, Graham SC, Luzio JP
Traffic (Copenhagen, Denmark)16(7)727-42(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction
Title: VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction.

VPS41 subunit of HOPS complex was defined to be the major partner for interacting with RILP.
Title: RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking.

Vps41 knockdown impairs late endosome fusion and fusion between late endosomes and lysosomes.
Title: The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion.

hVps41 and VAMP7 are specifically involved in the fusion of trans-Golgi network-derived lysosome-associated membrane protein carriers with late endosomes.
Title: hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins.

Both a functional heterotetrameric adaptor protein complex and a homotypic fusion and vacuole protein sorting-tethering complex are required for VPS41 to elicit neuroprotection in a transgenic model of Parkinson's disease.
Title: Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease.

The following VPS41 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VPS41 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06360	NM_014396.4 Latest version!	Homo sapiens VPS41 subunit of HOPS complex (VPS41), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu97163	XM_017011988.1 Latest version!	Homo sapiens VPS41 subunit of HOPS complex (VPS41), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu30332	NM_080631.3 Latest version!	Homo sapiens VPS41 subunit of HOPS complex (VPS41), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$580.30 $829.00
View Old Accession Versions >>
OHu06360	NM_014396.3	Homo sapiens VPS41, HOPS complex subunit (VPS41), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VPS41 ( NM_014396.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055211.2 Homo sapiens VPS41 subunit of HOPS complex (VPS41), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06360
Clone ID Related Accession (Same CDS sequence)	NM_014396.4 , NM_014396.3
Accession Version	NM_014396.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2565bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-13
Organism	Homo sapiens(human)
Product	vacuolar protein sorting-associated protein 41 homolog isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U87309.1, BC044851.1 and AC004850.3. On Nov 22, 2018 this sequence version replaced NM_014396.3. Transcript Variant: This variant (1) encodes the full-length isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.23467.1, SRR1660803.90518.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000310301.9/ ENSP00000309457.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGAAG CAGAGGAGCA GGAAACTGGG TCCCTTGAAG AATCTACAGA TGAGTCTGAG 
GAAGAAGAGA GCGAAGAGGA ACCCAAGCTG AAGTATGAAA GGCTTTCCAA TGGGGTAACT 
GAAATACTTC AGAAGGATGC AGCTAGCTGC ATGACAGTCC ATGACAAGTT TTTGGCATTG 
GGCACACATT ATGGCAAGGT TTATTTACTT GATGTCCAGG GGAACATCAC TCAGAAGTTT 
GATGTAAGTC CTGTGAAGAT AAATCAGATT AGCTTGGATG AAAGTGGAGA GCACATGGGT 
GTGTGTTCAG AGGATGGCAA GGTGCAGGTA TTTGGACTGT ATTCTGGAGA AGAATTTCAC 
GAGACTTTTG ACTGTCCCAT TAAAATTATT GCTGTGCACC CACATTTCGT GAGATCCAGT 
TGCAAGCAGT TTGTGACCGG AGGGAAGAAG CTGCTACTGT TTGAACGGTC TTGGATGAAC 
AGATGGAAGT CTGCTGTTCT GCATGAAGGG GAAGGGAACA TAAGGAGTGT GAAGTGGAGA 
GGCCATCTGA TTGCTTGGGC CAATAATATG GGTGTGAAGA TTTTTGACAT CATCTCAAAG 
CAAAGAATCA CCAATGTGCC CCGGGATGAT ATAAGTCTTC GCCCAGACAT GTATCCCTGC 
AGCCTCTGCT GGAAGGACAA TGTGACACTG ATTATTGGCT GGGGGACTTC TGTCAAGGTG 
TGCTCAGTGA AGGAACGGCA TGCCAGTGAA ATGAGGGATT TGCCAAGTCG ATATGTTGAA 
ATAGTGTCTC AGTTTGAAAC TGAATTCTAC ATCAGTGGAC TTGCACCTCT CTGTGATCAG 
CTTGTTGTAC TTTCGTATGT AAAGGAGATT TCAGAAAAAA CGGAAAGAGA ATACTGTGCC 
AGGCCTAGAC TGGACATCAT CCAGCCACTT TCTGAGACTT GTGAAGAGAT CTCTTCTGAT 
GCTTTGACAG TCAGAGGCTT TCAGGAGAAT GAATGTAGAG ATTATCATTT AGAATACTCT 
GAAGGGGAAT CACTTTTTTA CATCGTGAGT CCGAGAGATG TTGTAGTGGC CAAGGAACGA 
GACCAAGATG ATCACATTGA CTGGCTCCTT GAAAAGAAGA AATATGAAGA AGCATTGATG 
GCAGCTGAAA TTAGCCAAAA AAATATTAAA AGACATAAGA TTCTGGATAT TGGCTTGGCA 
TATATAAATC ACCTGGTGGA GAGAGGAGAC TATGACATAG CAGCACGCAA ATGCCAGAAA 
ATTCTTGGGA AAAATGCAGC ACTCTGGGAA TATGAAGTTT ATAAATTTAA AGAAATTGGA 
CAGCTTAAGG CTATTAGTCC TTATTTGCCA AGAGGTGATC CAGTTCTGAA ACCACTCATC 
TATGAAATGA TCTTACATGA ATTTTTGGAG AGTGATTATG AGGGTTTTGC CACATTGATC 
CGAGAATGGC CTGGAGATCT GTATAATAAT TCAGTCATAG TTCAAGCAGT TCGGGATCAT 
TTGAAGAAAG ATAGTCAGAA CAAGACTTTA CTTAAAACCC TGGCAGAATT GTACACCTAT 
GACAAGAACT ATGGCAATGC TCTGGAAATA TACTTAACAT TAAGACATAA AGACGTTTTT 
CAGTTGATCC ACAAGCATAA TCTTTTCAGT TCTATCAAGG ATAAAATTGT TTTATTAATG 
GATTTTGATT CAGAGAAAGC TGTTGACATG CTTTTGGACA ATGAAGATAA AATTTCAATT 
AAAAAGGTAG TGGAAGAATT GGAAGACAGA CCAGAGCTAC AGCATGTGTA TTTGCATAAG 
CTTTTCAAGA GAGACCACCA TAAGGGGCAG CGTTACCATG AAAAACAGAT CAGTCTTTAT 
GCTGAATATG ATCGACCAAA CTTACTTCCC TTTCTCCGAG ACAGTACCCA TTGCCCACTT 
GAAAAGGCTC TTGAGATCTG TCAACAGAGA AACTTTGTAG AAGAGACAGT TTATCTTCTG 
AGCCGAATGG GTAATAGCCG AAGTGCCCTG AAGATGATTA TGGAGGAATT ACATGATGTT 
GATAAAGCAA TCGAATTTGC CAAGGAGCAA GATGATGGAG AGCTGTGGGA AGATTTGATT 
TTATATTCCA TTGACAAACC ACCATTTATT ACTGGCTTGT TAAACAACAT TGGCACACAT 
GTTGACCCAA TTCTACTGAT TCACCGTATT AAGGAAGGAA TGGAGATCCC CAATTTGAGA 
GATTCCTTGG TTAAAATTCT GCAAGACTAC AATTTGCAAA TTCTGCTTCG TGAAGGCTGC 
AAGAAGATTC TCGTAGCTGA CTCTTTGTCC TTACTGAAGA AAATGCACCG AACTCAAATG 
AAAGGTGTTC TTGTTGATGA GGAGAACATC TGTGAGTCGT GCCTTTCCCC TATTCTTCCA 
TCAGATGCAG CTAAGCCCTT CAGCGTGGTG GTCTTCCATT GCCGGCACAT GTTCCACAAG 
GAGTGCCTGC CCATGCCCAG CATGAACTCT GCTGCACAGT TCTGCAACAT CTGCAGTGCT 
AAGAACCGTG GACCAGGAAG TGCAATTTTG GAGATGAAAA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055211.2
CDS	18..2582
Translation	MAEAEEQETGSLEESTDESEEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGNITQKFDVSPVKINQISLDESGEHMGVCSEDGKVQVFGLYSGEEFHETFDCPIKIIAVHPHFVRSSCKQFVTGGKKLLLFERSWMNRWKSAVLHEGEGNIRSVKWRGHLIAWANNMGVKIFDIISKQRITNVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSVKVCSVKERHASEMRDLPSRYVEIVSQFETEFYISGLAPLCDQLVVLSYVKEISEKTEREYCARPRLDIIQPLSETCEEISSDALTVRGFQENECRDYHLEYSEGESLFYIVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQKNIKRHKILDIGLAYINHLVERGDYDIAARKCQKILGKNAALWEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEENICESCLSPILPSDAAKPFSVVVFHCRHMFHKECLPMPSMNSAAQFCNICSAKNRGPGSAILEMKK

Target ORF information:

RefSeq Version	NM_014396.4
Organism	Homo sapiens(human)
Definition	Homo sapiens VPS41 subunit of HOPS complex (VPS41), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014396.4

ORF Insert Sequence:

ATGGCGGAAG CAGAGGAGCA GGAAACTGGG TCCCTTGAAG AATCTACAGA TGAGTCTGAG 
GAAGAAGAGA GCGAAGAGGA ACCCAAGCTG AAGTATGAAA GGCTTTCCAA TGGGGTAACT 
GAAATACTTC AGAAGGATGC AGCTAGCTGC ATGACAGTCC ATGACAAGTT TTTGGCATTG 
GGCACACATT ATGGCAAGGT TTATTTACTT GATGTCCAGG GGAACATCAC TCAGAAGTTT 
GATGTAAGTC CTGTGAAGAT AAATCAGATT AGCTTGGATG AAAGTGGAGA GCACATGGGT 
GTGTGTTCAG AGGATGGCAA GGTGCAGGTA TTTGGACTGT ATTCTGGAGA AGAATTTCAC 
GAGACTTTTG ACTGTCCCAT TAAAATTATT GCTGTGCACC CACATTTCGT GAGATCCAGT 
TGCAAGCAGT TTGTGACCGG AGGGAAGAAG CTGCTACTGT TTGAACGGTC TTGGATGAAC 
AGATGGAAGT CTGCTGTTCT GCATGAAGGG GAAGGGAACA TAAGGAGTGT GAAGTGGAGA 
GGCCATCTGA TTGCTTGGGC CAATAATATG GGTGTGAAGA TTTTTGACAT CATCTCAAAG 
CAAAGAATCA CCAATGTGCC CCGGGATGAT ATAAGTCTTC GCCCAGACAT GTATCCCTGC 
AGCCTCTGCT GGAAGGACAA TGTGACACTG ATTATTGGCT GGGGGACTTC TGTCAAGGTG 
TGCTCAGTGA AGGAACGGCA TGCCAGTGAA ATGAGGGATT TGCCAAGTCG ATATGTTGAA 
ATAGTGTCTC AGTTTGAAAC TGAATTCTAC ATCAGTGGAC TTGCACCTCT CTGTGATCAG 
CTTGTTGTAC TTTCGTATGT AAAGGAGATT TCAGAAAAAA CGGAAAGAGA ATACTGTGCC 
AGGCCTAGAC TGGACATCAT CCAGCCACTT TCTGAGACTT GTGAAGAGAT CTCTTCTGAT 
GCTTTGACAG TCAGAGGCTT TCAGGAGAAT GAATGTAGAG ATTATCATTT AGAATACTCT 
GAAGGGGAAT CACTTTTTTA CATCGTGAGT CCGAGAGATG TTGTAGTGGC CAAGGAACGA 
GACCAAGATG ATCACATTGA CTGGCTCCTT GAAAAGAAGA AATATGAAGA AGCATTGATG 
GCAGCTGAAA TTAGCCAAAA AAATATTAAA AGACATAAGA TTCTGGATAT TGGCTTGGCA 
TATATAAATC ACCTGGTGGA GAGAGGAGAC TATGACATAG CAGCACGCAA ATGCCAGAAA 
ATTCTTGGGA AAAATGCAGC ACTCTGGGAA TATGAAGTTT ATAAATTTAA AGAAATTGGA 
CAGCTTAAGG CTATTAGTCC TTATTTGCCA AGAGGTGATC CAGTTCTGAA ACCACTCATC 
TATGAAATGA TCTTACATGA ATTTTTGGAG AGTGATTATG AGGGTTTTGC CACATTGATC 
CGAGAATGGC CTGGAGATCT GTATAATAAT TCAGTCATAG TTCAAGCAGT TCGGGATCAT 
TTGAAGAAAG ATAGTCAGAA CAAGACTTTA CTTAAAACCC TGGCAGAATT GTACACCTAT 
GACAAGAACT ATGGCAATGC TCTGGAAATA TACTTAACAT TAAGACATAA AGACGTTTTT 
CAGTTGATCC ACAAGCATAA TCTTTTCAGT TCTATCAAGG ATAAAATTGT TTTATTAATG 
GATTTTGATT CAGAGAAAGC TGTTGACATG CTTTTGGACA ATGAAGATAA AATTTCAATT 
AAAAAGGTAG TGGAAGAATT GGAAGACAGA CCAGAGCTAC AGCATGTGTA TTTGCATAAG 
CTTTTCAAGA GAGACCACCA TAAGGGGCAG CGTTACCATG AAAAACAGAT CAGTCTTTAT 
GCTGAATATG ATCGACCAAA CTTACTTCCC TTTCTCCGAG ACAGTACCCA TTGCCCACTT 
GAAAAGGCTC TTGAGATCTG TCAACAGAGA AACTTTGTAG AAGAGACAGT TTATCTTCTG 
AGCCGAATGG GTAATAGCCG AAGTGCCCTG AAGATGATTA TGGAGGAATT ACATGATGTT 
GATAAAGCAA TCGAATTTGC CAAGGAGCAA GATGATGGAG AGCTGTGGGA AGATTTGATT 
TTATATTCCA TTGACAAACC ACCATTTATT ACTGGCTTGT TAAACAACAT TGGCACACAT 
GTTGACCCAA TTCTACTGAT TCACCGTATT AAGGAAGGAA TGGAGATCCC CAATTTGAGA 
GATTCCTTGG TTAAAATTCT GCAAGACTAC AATTTGCAAA TTCTGCTTCG TGAAGGCTGC 
AAGAAGATTC TCGTAGCTGA CTCTTTGTCC TTACTGAAGA AAATGCACCG AACTCAAATG 
AAAGGTGTTC TTGTTGATGA GGAGAACATC TGTGAGTCGT GCCTTTCCCC TATTCTTCCA 
TCAGATGCAG CTAAGCCCTT CAGCGTGGTG GTCTTCCATT GCCGGCACAT GTTCCACAAG 
GAGTGCCTGC CCATGCCCAG CATGAACTCT GCTGCACAGT TCTGCAACAT CTGCAGTGCT 
AAGAACCGTG GACCAGGAAG TGCAATTTTG GAGATGAAAA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VPS41 ( NM_014396.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055211.2 Homo sapiens VPS41, HOPS complex subunit (VPS41), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06360
Clone ID Related Accession (Same CDS sequence)	NM_014396.4 , NM_014396.3
Accession Version	NM_014396.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2565bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-31
Organism	Homo sapiens(human)
Product	vacuolar protein sorting-associated protein 41 homolog isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U87309.1, BC044851.1 and AC004850.3. On Sep 8, 2006 this sequence version replaced NM_014396.2. Transcript Variant: This variant (1) encodes the full-length isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U87309.1, SRR1660803.90518.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAAG CAGAGGAGCA GGAAACTGGG TCCCTTGAAG AATCTACAGA TGAGTCTGAG 
GAAGAAGAGA GCGAAGAGGA ACCCAAGCTG AAGTATGAAA GGCTTTCCAA TGGGGTAACT 
GAAATACTTC AGAAGGATGC AGCTAGCTGC ATGACAGTCC ATGACAAGTT TTTGGCATTG 
GGCACACATT ATGGCAAGGT TTATTTACTT GATGTCCAGG GGAACATCAC TCAGAAGTTT 
GATGTAAGTC CTGTGAAGAT AAATCAGATT AGCTTGGATG AAAGTGGAGA GCACATGGGT 
GTGTGTTCAG AGGATGGCAA GGTGCAGGTA TTTGGACTGT ATTCTGGAGA AGAATTTCAC 
GAGACTTTTG ACTGTCCCAT TAAAATTATT GCTGTGCACC CACATTTCGT GAGATCCAGT 
TGCAAGCAGT TTGTGACCGG AGGGAAGAAG CTGCTACTGT TTGAACGGTC TTGGATGAAC 
AGATGGAAGT CTGCTGTTCT GCATGAAGGG GAAGGGAACA TAAGGAGTGT GAAGTGGAGA 
GGCCATCTGA TTGCTTGGGC CAATAATATG GGTGTGAAGA TTTTTGACAT CATCTCAAAG 
CAAAGAATCA CCAATGTGCC CCGGGATGAT ATAAGTCTTC GCCCAGACAT GTATCCCTGC 
AGCCTCTGCT GGAAGGACAA TGTGACACTG ATTATTGGCT GGGGGACTTC TGTCAAGGTG 
TGCTCAGTGA AGGAACGGCA TGCCAGTGAA ATGAGGGATT TGCCAAGTCG ATATGTTGAA 
ATAGTGTCTC AGTTTGAAAC TGAATTCTAC ATCAGTGGAC TTGCACCTCT CTGTGATCAG 
CTTGTTGTAC TTTCGTATGT AAAGGAGATT TCAGAAAAAA CGGAAAGAGA ATACTGTGCC 
AGGCCTAGAC TGGACATCAT CCAGCCACTT TCTGAGACTT GTGAAGAGAT CTCTTCTGAT 
GCTTTGACAG TCAGAGGCTT TCAGGAGAAT GAATGTAGAG ATTATCATTT AGAATACTCT 
GAAGGGGAAT CACTTTTTTA CATCGTGAGT CCGAGAGATG TTGTAGTGGC CAAGGAACGA 
GACCAAGATG ATCACATTGA CTGGCTCCTT GAAAAGAAGA AATATGAAGA AGCATTGATG 
GCAGCTGAAA TTAGCCAAAA AAATATTAAA AGACATAAGA TTCTGGATAT TGGCTTGGCA 
TATATAAATC ACCTGGTGGA GAGAGGAGAC TATGACATAG CAGCACGCAA ATGCCAGAAA 
ATTCTTGGGA AAAATGCAGC ACTCTGGGAA TATGAAGTTT ATAAATTTAA AGAAATTGGA 
CAGCTTAAGG CTATTAGTCC TTATTTGCCA AGAGGTGATC CAGTTCTGAA ACCACTCATC 
TATGAAATGA TCTTACATGA ATTTTTGGAG AGTGATTATG AGGGTTTTGC CACATTGATC 
CGAGAATGGC CTGGAGATCT GTATAATAAT TCAGTCATAG TTCAAGCAGT TCGGGATCAT 
TTGAAGAAAG ATAGTCAGAA CAAGACTTTA CTTAAAACCC TGGCAGAATT GTACACCTAT 
GACAAGAACT ATGGCAATGC TCTGGAAATA TACTTAACAT TAAGACATAA AGACGTTTTT 
CAGTTGATCC ACAAGCATAA TCTTTTCAGT TCTATCAAGG ATAAAATTGT TTTATTAATG 
GATTTTGATT CAGAGAAAGC TGTTGACATG CTTTTGGACA ATGAAGATAA AATTTCAATT 
AAAAAGGTAG TGGAAGAATT GGAAGACAGA CCAGAGCTAC AGCATGTGTA TTTGCATAAG 
CTTTTCAAGA GAGACCACCA TAAGGGGCAG CGTTACCATG AAAAACAGAT CAGTCTTTAT 
GCTGAATATG ATCGACCAAA CTTACTTCCC TTTCTCCGAG ACAGTACCCA TTGCCCACTT 
GAAAAGGCTC TTGAGATCTG TCAACAGAGA AACTTTGTAG AAGAGACAGT TTATCTTCTG 
AGCCGAATGG GTAATAGCCG AAGTGCCCTG AAGATGATTA TGGAGGAATT ACATGATGTT 
GATAAAGCAA TCGAATTTGC CAAGGAGCAA GATGATGGAG AGCTGTGGGA AGATTTGATT 
TTATATTCCA TTGACAAACC ACCATTTATT ACTGGCTTGT TAAACAACAT TGGCACACAT 
GTTGACCCAA TTCTACTGAT TCACCGTATT AAGGAAGGAA TGGAGATCCC CAATTTGAGA 
GATTCCTTGG TTAAAATTCT GCAAGACTAC AATTTGCAAA TTCTGCTTCG TGAAGGCTGC 
AAGAAGATTC TCGTAGCTGA CTCTTTGTCC TTACTGAAGA AAATGCACCG AACTCAAATG 
AAAGGTGTTC TTGTTGATGA GGAGAACATC TGTGAGTCGT GCCTTTCCCC TATTCTTCCA 
TCAGATGCAG CTAAGCCCTT CAGCGTGGTG GTCTTCCATT GCCGGCACAT GTTCCACAAG 
GAGTGCCTGC CCATGCCCAG CATGAACTCT GCTGCACAGT TCTGCAACAT CTGCAGTGCT 
AAGAACCGTG GACCAGGAAG TGCAATTTTG GAGATGAAAA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055211.2
CDS	27..2591
Translation	MAEAEEQETGSLEESTDESEEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGNITQKFDVSPVKINQISLDESGEHMGVCSEDGKVQVFGLYSGEEFHETFDCPIKIIAVHPHFVRSSCKQFVTGGKKLLLFERSWMNRWKSAVLHEGEGNIRSVKWRGHLIAWANNMGVKIFDIISKQRITNVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSVKVCSVKERHASEMRDLPSRYVEIVSQFETEFYISGLAPLCDQLVVLSYVKEISEKTEREYCARPRLDIIQPLSETCEEISSDALTVRGFQENECRDYHLEYSEGESLFYIVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQKNIKRHKILDIGLAYINHLVERGDYDIAARKCQKILGKNAALWEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEENICESCLSPILPSDAAKPFSVVVFHCRHMFHKECLPMPSMNSAAQFCNICSAKNRGPGSAILEMKK

Target ORF information:

RefSeq Version	NM_014396.3
Organism	Homo sapiens(human)
Definition	Homo sapiens VPS41, HOPS complex subunit (VPS41), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014396.3

ORF Insert Sequence:

ATGGCGGAAG CAGAGGAGCA GGAAACTGGG TCCCTTGAAG AATCTACAGA TGAGTCTGAG 
GAAGAAGAGA GCGAAGAGGA ACCCAAGCTG AAGTATGAAA GGCTTTCCAA TGGGGTAACT 
GAAATACTTC AGAAGGATGC AGCTAGCTGC ATGACAGTCC ATGACAAGTT TTTGGCATTG 
GGCACACATT ATGGCAAGGT TTATTTACTT GATGTCCAGG GGAACATCAC TCAGAAGTTT 
GATGTAAGTC CTGTGAAGAT AAATCAGATT AGCTTGGATG AAAGTGGAGA GCACATGGGT 
GTGTGTTCAG AGGATGGCAA GGTGCAGGTA TTTGGACTGT ATTCTGGAGA AGAATTTCAC 
GAGACTTTTG ACTGTCCCAT TAAAATTATT GCTGTGCACC CACATTTCGT GAGATCCAGT 
TGCAAGCAGT TTGTGACCGG AGGGAAGAAG CTGCTACTGT TTGAACGGTC TTGGATGAAC 
AGATGGAAGT CTGCTGTTCT GCATGAAGGG GAAGGGAACA TAAGGAGTGT GAAGTGGAGA 
GGCCATCTGA TTGCTTGGGC CAATAATATG GGTGTGAAGA TTTTTGACAT CATCTCAAAG 
CAAAGAATCA CCAATGTGCC CCGGGATGAT ATAAGTCTTC GCCCAGACAT GTATCCCTGC 
AGCCTCTGCT GGAAGGACAA TGTGACACTG ATTATTGGCT GGGGGACTTC TGTCAAGGTG 
TGCTCAGTGA AGGAACGGCA TGCCAGTGAA ATGAGGGATT TGCCAAGTCG ATATGTTGAA 
ATAGTGTCTC AGTTTGAAAC TGAATTCTAC ATCAGTGGAC TTGCACCTCT CTGTGATCAG 
CTTGTTGTAC TTTCGTATGT AAAGGAGATT TCAGAAAAAA CGGAAAGAGA ATACTGTGCC 
AGGCCTAGAC TGGACATCAT CCAGCCACTT TCTGAGACTT GTGAAGAGAT CTCTTCTGAT 
GCTTTGACAG TCAGAGGCTT TCAGGAGAAT GAATGTAGAG ATTATCATTT AGAATACTCT 
GAAGGGGAAT CACTTTTTTA CATCGTGAGT CCGAGAGATG TTGTAGTGGC CAAGGAACGA 
GACCAAGATG ATCACATTGA CTGGCTCCTT GAAAAGAAGA AATATGAAGA AGCATTGATG 
GCAGCTGAAA TTAGCCAAAA AAATATTAAA AGACATAAGA TTCTGGATAT TGGCTTGGCA 
TATATAAATC ACCTGGTGGA GAGAGGAGAC TATGACATAG CAGCACGCAA ATGCCAGAAA 
ATTCTTGGGA AAAATGCAGC ACTCTGGGAA TATGAAGTTT ATAAATTTAA AGAAATTGGA 
CAGCTTAAGG CTATTAGTCC TTATTTGCCA AGAGGTGATC CAGTTCTGAA ACCACTCATC 
TATGAAATGA TCTTACATGA ATTTTTGGAG AGTGATTATG AGGGTTTTGC CACATTGATC 
CGAGAATGGC CTGGAGATCT GTATAATAAT TCAGTCATAG TTCAAGCAGT TCGGGATCAT 
TTGAAGAAAG ATAGTCAGAA CAAGACTTTA CTTAAAACCC TGGCAGAATT GTACACCTAT 
GACAAGAACT ATGGCAATGC TCTGGAAATA TACTTAACAT TAAGACATAA AGACGTTTTT 
CAGTTGATCC ACAAGCATAA TCTTTTCAGT TCTATCAAGG ATAAAATTGT TTTATTAATG 
GATTTTGATT CAGAGAAAGC TGTTGACATG CTTTTGGACA ATGAAGATAA AATTTCAATT 
AAAAAGGTAG TGGAAGAATT GGAAGACAGA CCAGAGCTAC AGCATGTGTA TTTGCATAAG 
CTTTTCAAGA GAGACCACCA TAAGGGGCAG CGTTACCATG AAAAACAGAT CAGTCTTTAT 
GCTGAATATG ATCGACCAAA CTTACTTCCC TTTCTCCGAG ACAGTACCCA TTGCCCACTT 
GAAAAGGCTC TTGAGATCTG TCAACAGAGA AACTTTGTAG AAGAGACAGT TTATCTTCTG 
AGCCGAATGG GTAATAGCCG AAGTGCCCTG AAGATGATTA TGGAGGAATT ACATGATGTT 
GATAAAGCAA TCGAATTTGC CAAGGAGCAA GATGATGGAG AGCTGTGGGA AGATTTGATT 
TTATATTCCA TTGACAAACC ACCATTTATT ACTGGCTTGT TAAACAACAT TGGCACACAT 
GTTGACCCAA TTCTACTGAT TCACCGTATT AAGGAAGGAA TGGAGATCCC CAATTTGAGA 
GATTCCTTGG TTAAAATTCT GCAAGACTAC AATTTGCAAA TTCTGCTTCG TGAAGGCTGC 
AAGAAGATTC TCGTAGCTGA CTCTTTGTCC TTACTGAAGA AAATGCACCG AACTCAAATG 
AAAGGTGTTC TTGTTGATGA GGAGAACATC TGTGAGTCGT GCCTTTCCCC TATTCTTCCA 
TCAGATGCAG CTAAGCCCTT CAGCGTGGTG GTCTTCCATT GCCGGCACAT GTTCCACAAG 
GAGTGCCTGC CCATGCCCAG CATGAACTCT GCTGCACAGT TCTGCAACAT CTGCAGTGCT 
AAGAACCGTG GACCAGGAAG TGCAATTTTG GAGATGAAAA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VPS41 ( XM_017011988.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016867477.1 Homo sapiens VPS41 subunit of HOPS complex (VPS41), transcript variant X2, mRNA.

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CloneID	OHu97163
Clone ID Related Accession (Same CDS sequence)	XM_017011988.1
Accession Version	XM_017011988.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1410bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	vacuolar protein sorting-associated protein 41 homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAGCTG AGAGAGGAGA GAATTCCAGG GATATTGGCT TGGCATATAT AAATCACCTG 
GTGGAGAGAG GAGACTATGA CATAGCAGCA CGCAAATGCC AGAAAATTCT TGGGAAAAAT 
GCAGCACTCT GGGAATATGA AGTTTATAAA TTTAAAGAAA TTGGACAGCT TAAGGCTATT 
AGTCCTTATT TGCCAAGAGG TGATCCAGTT CTGAAACCAC TCATCTATGA AATGATCTTA 
CATGAATTTT TGGAGAGTGA TTATGAGGGT TTTGCCACAT TGATCCGAGA ATGGCCTGGA 
GATCTGTATA ATAATTCAGT CATAGTTCAA GCAGTTCGGG ATCATTTGAA GAAAGATAGT 
CAGAACAAGA CTTTACTTAA AACCCTGGCA GAATTGTACA CCTATGACAA GAACTATGGC 
AATGCTCTGG AAATATACTT AACATTAAGA CATAAAGACG TTTTTCAGTT GATCCACAAG 
CATAATCTTT TCAGTTCTAT CAAGGATAAA ATTGTTTTAT TAATGGATTT TGATTCAGAG 
AAAGCTGTTG ACATGCTTTT GGACAATGAA GATAAAATTT CAATTAAAAA GGTAGTGGAA 
GAATTGGAAG ACAGACCAGA GCTACAGCAT GTGTATTTGC ATAAGCTTTT CAAGAGAGAC 
CACCATAAGG GGCAGCGTTA CCATGAAAAA CAGATCAGTC TTTATGCTGA ATATGATCGA 
CCAAACTTAC TTCCCTTTCT CCGAGACAGT ACCCATTGCC CACTTGAAAA GGCTCTTGAG 
ATCTGTCAAC AGAGAAACTT TGTAGAAGAG ACAGTTTATC TTCTGAGCCG AATGGGTAAT 
AGCCGAAGTG CCCTGAAGAT GATTATGGAG GAATTACATG ATGTTGATAA AGCAATCGAA 
TTTGCCAAGG AGCAAGATGA TGGAGAGCTG TGGGAAGATT TGATTTTATA TTCCATTGAC 
AAACCACCAT TTATTACTGG CTTGTTAAAC AACATTGGCA CACATGTTGA CCCAATTCTA 
CTGATTCACC GTATTAAGGA AGGAATGGAG ATCCCCAATT TGAGAGATTC CTTGGTTAAA 
ATTCTGCAAG ACTACAATTT GCAAATTCTG CTTCGTGAAG GCTGCAAGAA GATTCTCGTA 
GCTGACTCTT TGTCCTTACT GAAGAAAATG CACCGAACTC AAATGAAAGG TGTTCTTGTT 
GATGAGGAGA ACATCTGTGA GTCGTGCCTT TCCCCTATTC TTCCATCAGA TGCAGCTAAG 
CCCTTCAGCG TGGTGGTCTT CCATTGCCGG CACATGTTCC ACAAGGAGTG CCTGCCCATG 
CCCAGCATGA ACTCTGCTGC ACAGTTCTGC AACATCTGCA GTGCTAAGAA CCGTGGACCA 
GGAAGTGCAA TTTTGGAGAT GAAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016867477.1
CDS	115..1524
Translation	MGAERGENSRDIGLAYINHLVERGDYDIAARKCQKILGKNAALWEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEENICESCLSPILPSDAAKPFSVVVFHCRHMFHKECLPMPSMNSAAQFCNICSAKNRGPGSAILEMKK

Target ORF information:

RefSeq Version	XM_017011988.1
Organism	Homo sapiens(human)
Definition	Homo sapiens VPS41 subunit of HOPS complex (VPS41), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017011988.1

ORF Insert Sequence:

ATGGGAGCTG AGAGAGGAGA GAATTCCAGG GATATTGGCT TGGCATATAT AAATCACCTG 
GTGGAGAGAG GAGACTATGA CATAGCAGCA CGCAAATGCC AGAAAATTCT TGGGAAAAAT 
GCAGCACTCT GGGAATATGA AGTTTATAAA TTTAAAGAAA TTGGACAGCT TAAGGCTATT 
AGTCCTTATT TGCCAAGAGG TGATCCAGTT CTGAAACCAC TCATCTATGA AATGATCTTA 
CATGAATTTT TGGAGAGTGA TTATGAGGGT TTTGCCACAT TGATCCGAGA ATGGCCTGGA 
GATCTGTATA ATAATTCAGT CATAGTTCAA GCAGTTCGGG ATCATTTGAA GAAAGATAGT 
CAGAACAAGA CTTTACTTAA AACCCTGGCA GAATTGTACA CCTATGACAA GAACTATGGC 
AATGCTCTGG AAATATACTT AACATTAAGA CATAAAGACG TTTTTCAGTT GATCCACAAG 
CATAATCTTT TCAGTTCTAT CAAGGATAAA ATTGTTTTAT TAATGGATTT TGATTCAGAG 
AAAGCTGTTG ACATGCTTTT GGACAATGAA GATAAAATTT CAATTAAAAA GGTAGTGGAA 
GAATTGGAAG ACAGACCAGA GCTACAGCAT GTGTATTTGC ATAAGCTTTT CAAGAGAGAC 
CACCATAAGG GGCAGCGTTA CCATGAAAAA CAGATCAGTC TTTATGCTGA ATATGATCGA 
CCAAACTTAC TTCCCTTTCT CCGAGACAGT ACCCATTGCC CACTTGAAAA GGCTCTTGAG 
ATCTGTCAAC AGAGAAACTT TGTAGAAGAG ACAGTTTATC TTCTGAGCCG AATGGGTAAT 
AGCCGAAGTG CCCTGAAGAT GATTATGGAG GAATTACATG ATGTTGATAA AGCAATCGAA 
TTTGCCAAGG AGCAAGATGA TGGAGAGCTG TGGGAAGATT TGATTTTATA TTCCATTGAC 
AAACCACCAT TTATTACTGG CTTGTTAAAC AACATTGGCA CACATGTTGA CCCAATTCTA 
CTGATTCACC GTATTAAGGA AGGAATGGAG ATCCCCAATT TGAGAGATTC CTTGGTTAAA 
ATTCTGCAAG ACTACAATTT GCAAATTCTG CTTCGTGAAG GCTGCAAGAA GATTCTCGTA 
GCTGACTCTT TGTCCTTACT GAAGAAAATG CACCGAACTC AAATGAAAGG TGTTCTTGTT 
GATGAGGAGA ACATCTGTGA GTCGTGCCTT TCCCCTATTC TTCCATCAGA TGCAGCTAAG 
CCCTTCAGCG TGGTGGTCTT CCATTGCCGG CACATGTTCC ACAAGGAGTG CCTGCCCATG 
CCCAGCATGA ACTCTGCTGC ACAGTTCTGC AACATCTGCA GTGCTAAGAA CCGTGGACCA 
GGAAGTGCAA TTTTGGAGAT GAAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VPS41 ( NM_080631.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_542198.2 Homo sapiens VPS41 subunit of HOPS complex (VPS41), transcript variant 2, mRNA.

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CloneID	OHu30332
Clone ID Related Accession (Same CDS sequence)	NM_080631.3
Accession Version	NM_080631.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2490bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-13
Organism	Homo sapiens(human)
Product	vacuolar protein sorting-associated protein 41 homolog isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U87309.1, BC044851.1 and AC004850.3. On Sep 8, 2006 this sequence version replaced NM_080631.2. Transcript Variant: This variant (2) is missing a sequence segment in the coding region compared to transcript variant 1. However, it maintains the same reading frame and encodes an isoform (2) which is 25 aa shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.196466.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAAG CAGAGGAGCA GGAAACTGGG TCCCTTGAAG AATCTACAGA TGAGTCTGAG 
GAAGAAGAGA GCGAAGAGGA ACCCAAGCTG AAGTATGAAA GGCTTTCCAA TGGGGTAACT 
GAAATACTTC AGAAGGATGC AGCTAGCTGC ATGACAGTCC ATGACAAGTT TTTGGCATTG 
GGCACACATT ATGGCAAGGT TTATTTACTT GATGTCCAGG GGAACATCAC TCAGAAGTTT 
GATGTAGTGC AGGTATTTGG ACTGTATTCT GGAGAAGAAT TTCACGAGAC TTTTGACTGT 
CCCATTAAAA TTATTGCTGT GCACCCACAT TTCGTGAGAT CCAGTTGCAA GCAGTTTGTG 
ACCGGAGGGA AGAAGCTGCT ACTGTTTGAA CGGTCTTGGA TGAACAGATG GAAGTCTGCT 
GTTCTGCATG AAGGGGAAGG GAACATAAGG AGTGTGAAGT GGAGAGGCCA TCTGATTGCT 
TGGGCCAATA ATATGGGTGT GAAGATTTTT GACATCATCT CAAAGCAAAG AATCACCAAT 
GTGCCCCGGG ATGATATAAG TCTTCGCCCA GACATGTATC CCTGCAGCCT CTGCTGGAAG 
GACAATGTGA CACTGATTAT TGGCTGGGGG ACTTCTGTCA AGGTGTGCTC AGTGAAGGAA 
CGGCATGCCA GTGAAATGAG GGATTTGCCA AGTCGATATG TTGAAATAGT GTCTCAGTTT 
GAAACTGAAT TCTACATCAG TGGACTTGCA CCTCTCTGTG ATCAGCTTGT TGTACTTTCG 
TATGTAAAGG AGATTTCAGA AAAAACGGAA AGAGAATACT GTGCCAGGCC TAGACTGGAC 
ATCATCCAGC CACTTTCTGA GACTTGTGAA GAGATCTCTT CTGATGCTTT GACAGTCAGA 
GGCTTTCAGG AGAATGAATG TAGAGATTAT CATTTAGAAT ACTCTGAAGG GGAATCACTT 
TTTTACATCG TGAGTCCGAG AGATGTTGTA GTGGCCAAGG AACGAGACCA AGATGATCAC 
ATTGACTGGC TCCTTGAAAA GAAGAAATAT GAAGAAGCAT TGATGGCAGC TGAAATTAGC 
CAAAAAAATA TTAAAAGACA TAAGATTCTG GATATTGGCT TGGCATATAT AAATCACCTG 
GTGGAGAGAG GAGACTATGA CATAGCAGCA CGCAAATGCC AGAAAATTCT TGGGAAAAAT 
GCAGCACTCT GGGAATATGA AGTTTATAAA TTTAAAGAAA TTGGACAGCT TAAGGCTATT 
AGTCCTTATT TGCCAAGAGG TGATCCAGTT CTGAAACCAC TCATCTATGA AATGATCTTA 
CATGAATTTT TGGAGAGTGA TTATGAGGGT TTTGCCACAT TGATCCGAGA ATGGCCTGGA 
GATCTGTATA ATAATTCAGT CATAGTTCAA GCAGTTCGGG ATCATTTGAA GAAAGATAGT 
CAGAACAAGA CTTTACTTAA AACCCTGGCA GAATTGTACA CCTATGACAA GAACTATGGC 
AATGCTCTGG AAATATACTT AACATTAAGA CATAAAGACG TTTTTCAGTT GATCCACAAG 
CATAATCTTT TCAGTTCTAT CAAGGATAAA ATTGTTTTAT TAATGGATTT TGATTCAGAG 
AAAGCTGTTG ACATGCTTTT GGACAATGAA GATAAAATTT CAATTAAAAA GGTAGTGGAA 
GAATTGGAAG ACAGACCAGA GCTACAGCAT GTGTATTTGC ATAAGCTTTT CAAGAGAGAC 
CACCATAAGG GGCAGCGTTA CCATGAAAAA CAGATCAGTC TTTATGCTGA ATATGATCGA 
CCAAACTTAC TTCCCTTTCT CCGAGACAGT ACCCATTGCC CACTTGAAAA GGCTCTTGAG 
ATCTGTCAAC AGAGAAACTT TGTAGAAGAG ACAGTTTATC TTCTGAGCCG AATGGGTAAT 
AGCCGAAGTG CCCTGAAGAT GATTATGGAG GAATTACATG ATGTTGATAA AGCAATCGAA 
TTTGCCAAGG AGCAAGATGA TGGAGAGCTG TGGGAAGATT TGATTTTATA TTCCATTGAC 
AAACCACCAT TTATTACTGG CTTGTTAAAC AACATTGGCA CACATGTTGA CCCAATTCTA 
CTGATTCACC GTATTAAGGA AGGAATGGAG ATCCCCAATT TGAGAGATTC CTTGGTTAAA 
ATTCTGCAAG ACTACAATTT GCAAATTCTG CTTCGTGAAG GCTGCAAGAA GATTCTCGTA 
GCTGACTCTT TGTCCTTACT GAAGAAAATG CACCGAACTC AAATGAAAGG TGTTCTTGTT 
GATGAGGAGA ACATCTGTGA GTCGTGCCTT TCCCCTATTC TTCCATCAGA TGCAGCTAAG 
CCCTTCAGCG TGGTGGTCTT CCATTGCCGG CACATGTTCC ACAAGGAGTG CCTGCCCATG 
CCCAGCATGA ACTCTGCTGC ACAGTTCTGC AACATCTGCA GTGCTAAGAA CCGTGGACCA 
GGAAGTGCAA TTTTGGAGAT GAAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542198.2
CDS	27..2516
Translation	MAEAEEQETGSLEESTDESEEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGNITQKFDVVQVFGLYSGEEFHETFDCPIKIIAVHPHFVRSSCKQFVTGGKKLLLFERSWMNRWKSAVLHEGEGNIRSVKWRGHLIAWANNMGVKIFDIISKQRITNVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSVKVCSVKERHASEMRDLPSRYVEIVSQFETEFYISGLAPLCDQLVVLSYVKEISEKTEREYCARPRLDIIQPLSETCEEISSDALTVRGFQENECRDYHLEYSEGESLFYIVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQKNIKRHKILDIGLAYINHLVERGDYDIAARKCQKILGKNAALWEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEENICESCLSPILPSDAAKPFSVVVFHCRHMFHKECLPMPSMNSAAQFCNICSAKNRGPGSAILEMKK

Target ORF information:

RefSeq Version	NM_080631.3
Organism	Homo sapiens(human)
Definition	Homo sapiens VPS41 subunit of HOPS complex (VPS41), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080631.3

ORF Insert Sequence:

ATGGCGGAAG CAGAGGAGCA GGAAACTGGG TCCCTTGAAG AATCTACAGA TGAGTCTGAG 
GAAGAAGAGA GCGAAGAGGA ACCCAAGCTG AAGTATGAAA GGCTTTCCAA TGGGGTAACT 
GAAATACTTC AGAAGGATGC AGCTAGCTGC ATGACAGTCC ATGACAAGTT TTTGGCATTG 
GGCACACATT ATGGCAAGGT TTATTTACTT GATGTCCAGG GGAACATCAC TCAGAAGTTT 
GATGTAGTGC AGGTATTTGG ACTGTATTCT GGAGAAGAAT TTCACGAGAC TTTTGACTGT 
CCCATTAAAA TTATTGCTGT GCACCCACAT TTCGTGAGAT CCAGTTGCAA GCAGTTTGTG 
ACCGGAGGGA AGAAGCTGCT ACTGTTTGAA CGGTCTTGGA TGAACAGATG GAAGTCTGCT 
GTTCTGCATG AAGGGGAAGG GAACATAAGG AGTGTGAAGT GGAGAGGCCA TCTGATTGCT 
TGGGCCAATA ATATGGGTGT GAAGATTTTT GACATCATCT CAAAGCAAAG AATCACCAAT 
GTGCCCCGGG ATGATATAAG TCTTCGCCCA GACATGTATC CCTGCAGCCT CTGCTGGAAG 
GACAATGTGA CACTGATTAT TGGCTGGGGG ACTTCTGTCA AGGTGTGCTC AGTGAAGGAA 
CGGCATGCCA GTGAAATGAG GGATTTGCCA AGTCGATATG TTGAAATAGT GTCTCAGTTT 
GAAACTGAAT TCTACATCAG TGGACTTGCA CCTCTCTGTG ATCAGCTTGT TGTACTTTCG 
TATGTAAAGG AGATTTCAGA AAAAACGGAA AGAGAATACT GTGCCAGGCC TAGACTGGAC 
ATCATCCAGC CACTTTCTGA GACTTGTGAA GAGATCTCTT CTGATGCTTT GACAGTCAGA 
GGCTTTCAGG AGAATGAATG TAGAGATTAT CATTTAGAAT ACTCTGAAGG GGAATCACTT 
TTTTACATCG TGAGTCCGAG AGATGTTGTA GTGGCCAAGG AACGAGACCA AGATGATCAC 
ATTGACTGGC TCCTTGAAAA GAAGAAATAT GAAGAAGCAT TGATGGCAGC TGAAATTAGC 
CAAAAAAATA TTAAAAGACA TAAGATTCTG GATATTGGCT TGGCATATAT AAATCACCTG 
GTGGAGAGAG GAGACTATGA CATAGCAGCA CGCAAATGCC AGAAAATTCT TGGGAAAAAT 
GCAGCACTCT GGGAATATGA AGTTTATAAA TTTAAAGAAA TTGGACAGCT TAAGGCTATT 
AGTCCTTATT TGCCAAGAGG TGATCCAGTT CTGAAACCAC TCATCTATGA AATGATCTTA 
CATGAATTTT TGGAGAGTGA TTATGAGGGT TTTGCCACAT TGATCCGAGA ATGGCCTGGA 
GATCTGTATA ATAATTCAGT CATAGTTCAA GCAGTTCGGG ATCATTTGAA GAAAGATAGT 
CAGAACAAGA CTTTACTTAA AACCCTGGCA GAATTGTACA CCTATGACAA GAACTATGGC 
AATGCTCTGG AAATATACTT AACATTAAGA CATAAAGACG TTTTTCAGTT GATCCACAAG 
CATAATCTTT TCAGTTCTAT CAAGGATAAA ATTGTTTTAT TAATGGATTT TGATTCAGAG 
AAAGCTGTTG ACATGCTTTT GGACAATGAA GATAAAATTT CAATTAAAAA GGTAGTGGAA 
GAATTGGAAG ACAGACCAGA GCTACAGCAT GTGTATTTGC ATAAGCTTTT CAAGAGAGAC 
CACCATAAGG GGCAGCGTTA CCATGAAAAA CAGATCAGTC TTTATGCTGA ATATGATCGA 
CCAAACTTAC TTCCCTTTCT CCGAGACAGT ACCCATTGCC CACTTGAAAA GGCTCTTGAG 
ATCTGTCAAC AGAGAAACTT TGTAGAAGAG ACAGTTTATC TTCTGAGCCG AATGGGTAAT 
AGCCGAAGTG CCCTGAAGAT GATTATGGAG GAATTACATG ATGTTGATAA AGCAATCGAA 
TTTGCCAAGG AGCAAGATGA TGGAGAGCTG TGGGAAGATT TGATTTTATA TTCCATTGAC 
AAACCACCAT TTATTACTGG CTTGTTAAAC AACATTGGCA CACATGTTGA CCCAATTCTA 
CTGATTCACC GTATTAAGGA AGGAATGGAG ATCCCCAATT TGAGAGATTC CTTGGTTAAA 
ATTCTGCAAG ACTACAATTT GCAAATTCTG CTTCGTGAAG GCTGCAAGAA GATTCTCGTA 
GCTGACTCTT TGTCCTTACT GAAGAAAATG CACCGAACTC AAATGAAAGG TGTTCTTGTT 
GATGAGGAGA ACATCTGTGA GTCGTGCCTT TCCCCTATTC TTCCATCAGA TGCAGCTAAG 
CCCTTCAGCG TGGTGGTCTT CCATTGCCGG CACATGTTCC ACAAGGAGTG CCTGCCCATG 
CCCAGCATGA ACTCTGCTGC ACAGTTCTGC AACATCTGCA GTGCTAAGAA CCGTGGACCA 
GGAAGTGCAA TTTTGGAGAT GAAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction.
The Biochemical journal474(21)3615-3626(2017 10)
Hunter MR,Scourfield EJ,Emmott E,Graham SC

Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.
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A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
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Traffic (Copenhagen, Denmark)16(7)727-42(2015 Jul)
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VPS41 cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

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