LAT cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LAT
Entrez Gene ID	27040
Full Name	linker for activation of T cells
Synonyms	IMD52,LAT1,pp36
General protein information	Preferred Names linker for activation of T cells Names linker for activation of T-cells family member 1 36 kDa phospho-tyrosine adapter protein 36 kDa phospho-tyrosine adaptor protein linker for activation of T cells, transmembrane adaptor p36-38
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p11.2
Summary	The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Disorder MIM:	602354
Disorder Html:	Immunodeficiency 52, 617514 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001014987.2	NP_001014987.1	linker for activation of T-cells family member 1 isoform b
NM_014387.4	NP_055202.1	linker for activation of T-cells family member 1 isoform a
NM_014387.3	NP_055202.1	linker for activation of T-cells family member 1 isoform a
NM_001014988.1	NP_001014988.1	linker for activation of T-cells family member 1 isoform c
NM_001014987.1	NP_001014987.1	linker for activation of T-cells family member 1 isoform b
NM_001014989.1	NP_001014989.2	linker for activation of T-cells family member 1 isoform d
NM_001014988.2	NP_001014988.1	linker for activation of T-cells family member 1 isoform c
NM_001014989.2	NP_001014989.2	linker for activation of T-cells family member 1 isoform d

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LAT	XP_001147360.2
	LAT	XP_001102058.2
Canis lupus familiaris (dog)	LAT	XP_005621440.1
Mus musculus (house mouse)	Lat	NP_034819.1
Rattus norvegicus (Norway rat)	Lat	NP_110480.1
Bos taurus (cattle)	LAT	NP_001098448.1
Homo sapiens (human)	LAT	NP_001014989.2

Gene Ontology
Bibliography

Related articles in PubMed

Dynamic Scaling Analysis of Molecular Motion within the LAT:Grb2:SOS Protein Network on?Membranes.
Huang WYC, Chiang HK, Groves JT
Biophysical journal113(8)1807-1813(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study examined molecular mobility within LAT:Grb2:SOS assemblies on supported membranes by single-molecule tracking. Trajectory analysis reveals a discrete temporal transition to subdiffusive motion below a characteristic timescale, indicating that the LAT:Grb2:SOS assembly has the dynamical structure of a loosely entangled polymer.
Title: Dynamic Scaling Analysis of Molecular Motion within the LAT:Grb2:SOS Protein Network on?Membranes.

Overexpression of LAT is associated with microcephaly.
Title: The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs.

Data indicate that the T cell-specific adaptor protein (TSAd) SH2 domain interacts with CD6 antigen and linker for activation of T cells protein (LAT) phosphotyrosine (pTyr) peptides.
Title: CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell-Specific Adaptor Protein.

this study shows that inherited LAT deficiency should be considered in patients with combined immunodeficiency with T-cell abnormalities
Title: Mutations in linker for activation of T?cells (LAT) lead to a novel form of severe combined immunodeficiency.

LAT and SLP-76 are randomly dispersed throughout the clusters that form upon T cell receptor engagement.
Title: Development of nanoscale structure in LAT-based signaling complexes.

The following LAT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LAT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17064	NM_001014987.2 Latest version!	Homo sapiens linker for activation of T cells (LAT), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu17631	NM_001014989.2 Latest version!	Homo sapiens linker for activation of T cells (LAT), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu17129	NM_001014988.2 Latest version!	Homo sapiens linker for activation of T cells (LAT), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OHu17155	NM_014387.4 Latest version!	Homo sapiens linker for activation of T cells (LAT), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu17155	NM_014387.3	Homo sapiens linker for activation of T cells (LAT), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu17064	NM_001014987.1	Homo sapiens linker for activation of T cells (LAT), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu17129	NM_001014988.1	Homo sapiens linker for activation of T cells (LAT), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OHu17631	NM_001014989.1	Homo sapiens linker for activation of T cells (LAT), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LAT ( NM_001014987.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001014987.1 Homo sapiens linker for activation of T cells (LAT), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17064
Clone ID Related Accession (Same CDS sequence)	NM_001014987.2 , NM_001014987.1
Accession Version	NM_001014987.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-02
Organism	Homo sapiens(human)
Product	linker for activation of T-cells family member 1 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC109460.3, BI769296.1, AJ223280.1 and BC011563.1. On Jun 2, 2019 this sequence version replaced NM_001014987.1. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (b) is shorter at the N-terminus compared to isoform d. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ223280.1, ERR279827.2531.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGGAGG CCATCCTGGT CCCCTGCGTG CTGGGGCTCC TGCTGCTGCC CATCCTGGCC 
ATGTTGATGG CACTGTGTGT GCACTGCCAC AGACTGCCAG GCTCCTACGA CAGCACATCC 
TCAGATAGTT TGTATCCAAG GGGCATCCAG TTCAAACGGC CTCACACGGT TGCCCCCTGG 
CCACCTGCCT ACCCACCTGT CACCTCCTAC CCACCCCTGA GCCAGCCAGA CCTGCTCCCC 
ATCCCAAGAT CCCCGCAGCC CCTTGGGGGC TCCCACCGGA CGCCATCTTC CCGGCGGGAT 
TCTGATGGTG CCAACAGTGT GGCGAGCTAC GAGAACGAGG AACCAGCCTG TGAGGATGCG 
GATGAGGATG AGGACGACTA TCACAACCCA GGCTACCTGG TGGTGCTTCC TGACAGCACC 
CCGGCCACTA GCACTGCTGC CCCATCAGCT CCTGCACTCA GCACCCCTGG CATCCGAGAC 
AGTGCCTTCT CCATGGAGTC CATTGATGAT TACGTGAACG TTCCGGAGAG CGGGGAGAGC 
GCAGAAGCGT CTCTGGATGG CAGCCGGGAG TATGTGAATG TGTCCCAGGA ACTGCATCCT 
GGAGCGGCTA AGACTGAGCC TGCCGCCCTG AGTTCCCAGG AGGCAGAGGA AGTGGAGGAA 
GAGGGGGCTC CAGATTACGA GAATCTGCAG GAGCTGAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014987.1
CDS	367..1068
Translation	MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN

Target ORF information:

RefSeq Version	NM_001014987.2
Organism	Homo sapiens(human)
Definition	Homo sapiens linker for activation of T cells (LAT), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014987.2

ORF Insert Sequence:

ATGGAGGAGG CCATCCTGGT CCCCTGCGTG CTGGGGCTCC TGCTGCTGCC CATCCTGGCC 
ATGTTGATGG CACTGTGTGT GCACTGCCAC AGACTGCCAG GCTCCTACGA CAGCACATCC 
TCAGATAGTT TGTATCCAAG GGGCATCCAG TTCAAACGGC CTCACACGGT TGCCCCCTGG 
CCACCTGCCT ACCCACCTGT CACCTCCTAC CCACCCCTGA GCCAGCCAGA CCTGCTCCCC 
ATCCCAAGAT CCCCGCAGCC CCTTGGGGGC TCCCACCGGA CGCCATCTTC CCGGCGGGAT 
TCTGATGGTG CCAACAGTGT GGCGAGCTAC GAGAACGAGG AACCAGCCTG TGAGGATGCG 
GATGAGGATG AGGACGACTA TCACAACCCA GGCTACCTGG TGGTGCTTCC TGACAGCACC 
CCGGCCACTA GCACTGCTGC CCCATCAGCT CCTGCACTCA GCACCCCTGG CATCCGAGAC 
AGTGCCTTCT CCATGGAGTC CATTGATGAT TACGTGAACG TTCCGGAGAG CGGGGAGAGC 
GCAGAAGCGT CTCTGGATGG CAGCCGGGAG TATGTGAATG TGTCCCAGGA ACTGCATCCT 
GGAGCGGCTA AGACTGAGCC TGCCGCCCTG AGTTCCCAGG AGGCAGAGGA AGTGGAGGAA 
GAGGGGGCTC CAGATTACGA GAATCTGCAG GAGCTGAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAT ( NM_001014987.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001014987.1 Homo sapiens linker for activation of T cells (LAT), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17064
Clone ID Related Accession (Same CDS sequence)	NM_001014987.2 , NM_001014987.1
Accession Version	NM_001014987.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-22
Organism	Homo sapiens(human)
Product	linker for activation of T-cells family member 1 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI769296.1, AJ223280.1 and BC011563.1. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (b) is shorter at the N-terminus compared to isoform d. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279867.3029.1, AJ223280.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGAGG CCATCCTGGT CCCCTGCGTG CTGGGGCTCC TGCTGCTGCC CATCCTGGCC 
ATGTTGATGG CACTGTGTGT GCACTGCCAC AGACTGCCAG GCTCCTACGA CAGCACATCC 
TCAGATAGTT TGTATCCAAG GGGCATCCAG TTCAAACGGC CTCACACGGT TGCCCCCTGG 
CCACCTGCCT ACCCACCTGT CACCTCCTAC CCACCCCTGA GCCAGCCAGA CCTGCTCCCC 
ATCCCAAGAT CCCCGCAGCC CCTTGGGGGC TCCCACCGGA CGCCATCTTC CCGGCGGGAT 
TCTGATGGTG CCAACAGTGT GGCGAGCTAC GAGAACGAGG AACCAGCCTG TGAGGATGCG 
GATGAGGATG AGGACGACTA TCACAACCCA GGCTACCTGG TGGTGCTTCC TGACAGCACC 
CCGGCCACTA GCACTGCTGC CCCATCAGCT CCTGCACTCA GCACCCCTGG CATCCGAGAC 
AGTGCCTTCT CCATGGAGTC CATTGATGAT TACGTGAACG TTCCGGAGAG CGGGGAGAGC 
GCAGAAGCGT CTCTGGATGG CAGCCGGGAG TATGTGAATG TGTCCCAGGA ACTGCATCCT 
GGAGCGGCTA AGACTGAGCC TGCCGCCCTG AGTTCCCAGG AGGCAGAGGA AGTGGAGGAA 
GAGGGGGCTC CAGATTACGA GAATCTGCAG GAGCTGAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014987.1
CDS	353..1054
Translation	MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN

Target ORF information:

RefSeq Version	NM_001014987.1
Organism	Homo sapiens(human)
Definition	Homo sapiens linker for activation of T cells (LAT), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014987.1

ORF Insert Sequence:

ATGGAGGAGG CCATCCTGGT CCCCTGCGTG CTGGGGCTCC TGCTGCTGCC CATCCTGGCC 
ATGTTGATGG CACTGTGTGT GCACTGCCAC AGACTGCCAG GCTCCTACGA CAGCACATCC 
TCAGATAGTT TGTATCCAAG GGGCATCCAG TTCAAACGGC CTCACACGGT TGCCCCCTGG 
CCACCTGCCT ACCCACCTGT CACCTCCTAC CCACCCCTGA GCCAGCCAGA CCTGCTCCCC 
ATCCCAAGAT CCCCGCAGCC CCTTGGGGGC TCCCACCGGA CGCCATCTTC CCGGCGGGAT 
TCTGATGGTG CCAACAGTGT GGCGAGCTAC GAGAACGAGG AACCAGCCTG TGAGGATGCG 
GATGAGGATG AGGACGACTA TCACAACCCA GGCTACCTGG TGGTGCTTCC TGACAGCACC 
CCGGCCACTA GCACTGCTGC CCCATCAGCT CCTGCACTCA GCACCCCTGG CATCCGAGAC 
AGTGCCTTCT CCATGGAGTC CATTGATGAT TACGTGAACG TTCCGGAGAG CGGGGAGAGC 
GCAGAAGCGT CTCTGGATGG CAGCCGGGAG TATGTGAATG TGTCCCAGGA ACTGCATCCT 
GGAGCGGCTA AGACTGAGCC TGCCGCCCTG AGTTCCCAGG AGGCAGAGGA AGTGGAGGAA 
GAGGGGGCTC CAGATTACGA GAATCTGCAG GAGCTGAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAT ( NM_001014989.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001014989.2 Homo sapiens linker for activation of T cells (LAT), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu17631
Clone ID Related Accession (Same CDS sequence)	NM_001014989.1 , NM_001014989.2
Accession Version	NM_001014989.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-22
Organism	Homo sapiens(human)
Product	linker for activation of T-cells family member 1 isoform d
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC011563.1. Transcript Variant: This variant (4) encodes the longest isoform (d). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011563.1, BM810074.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2152719 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCCA CGGCTGCCAG CTGGCAGGTG GCTGTCCCCG TCTTGGGGGG GGCCAGCAGA 
CCCTTGGGGC CTAGGGGTGC AGCCAGCCTG CTCCGAGCTC CCCTGCAGAT GGAGGAGGCC 
ATCCTGGTCC CCTGCGTGCT GGGGCTCCTG CTGCTGCCCA TCCTGGCCAT GTTGATGGCA 
CTGTGTGTGC ACTGCCACAG ACTGCCAGGC TCCTACGACA GCACATCCTC AGATAGTTTG 
TATCCAAGGG GCATCCAGTT CAAACGGCCT CACACGGTTG CCCCCTGGCC ACCTGCCTAC 
CCACCTGTCA CCTCCTACCC ACCCCTGAGC CAGCCAGACC TGCTCCCCAT CCCAAGATCC 
CCGCAGCCCC TTGGGGGCTC CCACCGGACG CCATCTTCCC GGCGGGATTC TGATGGTGCC 
AACAGTGTGG CGAGCTACGA GAACGAGGAA CCAGCCTGTG AGGATGCGGA TGAGGATGAG 
GACGACTATC ACAACCCAGG CTACCTGGTG GTGCTTCCTG ACAGCACCCC GGCCACTAGC 
ACTGCTGCCC CATCAGCTCC TGCACTCAGC ACCCCTGGCA TCCGAGACAG TGCCTTCTCC 
ATGGAGTCCA TTGATGATTA CGTGAACGTT CCGGAGAGCG GGGAGAGCGC AGAAGCGTCT 
CTGGATGGCA GCCGGGAGTA TGTGAATGTG TCCCAGGAAC TGCATCCTGG AGCGGCTAAG 
ACTGAGCCTG CCGCCCTGAG TTCCCAGGAG GCAGAGGAAG TGGAGGAAGA GGGGGCTCCA 
GATTACGAGA ATCTGCAGGA GCTGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014989.2
CDS	37..846
Translation	MEATAASWQVAVPVLGGASRPLGPRGAASLLRAPLQMEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN

Target ORF information:

RefSeq Version	NM_001014989.1
Organism	Homo sapiens(human)
Definition	Homo sapiens linker for activation of T cells (LAT), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014989.1

ORF Insert Sequence:

ATGGAGGCCA CGGCTGCCAG CTGGCAGGTG GCTGTCCCCG TCTTGGGGGG GGCCAGCAGA 
CCCTTGGGGC CTAGGGGTGC AGCCAGCCTG CTCCGAGCTC CCCTGCAGAT GGAGGAGGCC 
ATCCTGGTCC CCTGCGTGCT GGGGCTCCTG CTGCTGCCCA TCCTGGCCAT GTTGATGGCA 
CTGTGTGTGC ACTGCCACAG ACTGCCAGGC TCCTACGACA GCACATCCTC AGATAGTTTG 
TATCCAAGGG GCATCCAGTT CAAACGGCCT CACACGGTTG CCCCCTGGCC ACCTGCCTAC 
CCACCTGTCA CCTCCTACCC ACCCCTGAGC CAGCCAGACC TGCTCCCCAT CCCAAGATCC 
CCGCAGCCCC TTGGGGGCTC CCACCGGACG CCATCTTCCC GGCGGGATTC TGATGGTGCC 
AACAGTGTGG CGAGCTACGA GAACGAGGAA CCAGCCTGTG AGGATGCGGA TGAGGATGAG 
GACGACTATC ACAACCCAGG CTACCTGGTG GTGCTTCCTG ACAGCACCCC GGCCACTAGC 
ACTGCTGCCC CATCAGCTCC TGCACTCAGC ACCCCTGGCA TCCGAGACAG TGCCTTCTCC 
ATGGAGTCCA TTGATGATTA CGTGAACGTT CCGGAGAGCG GGGAGAGCGC AGAAGCGTCT 
CTGGATGGCA GCCGGGAGTA TGTGAATGTG TCCCAGGAAC TGCATCCTGG AGCGGCTAAG 
ACTGAGCCTG CCGCCCTGAG TTCCCAGGAG GCAGAGGAAG TGGAGGAAGA GGGGGCTCCA 
GATTACGAGA ATCTGCAGGA GCTGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAT ( NM_001014989.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001014989.2 Homo sapiens linker for activation of T cells (LAT), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu17631
Clone ID Related Accession (Same CDS sequence)	NM_001014989.1 , NM_001014989.2
Accession Version	NM_001014989.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	linker for activation of T-cells family member 1 isoform d
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC109460.3 and BC011563.1. On Jun 2, 2019 this sequence version replaced NM_001014989.1. Transcript Variant: This variant (4) encodes the longest isoform (d). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011563.1, BM810074.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2152719 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCCA CGGCTGCCAG CTGGCAGGTG GCTGTCCCCG TCTTGGGGGG GGCCAGCAGA 
CCCTTGGGGC CTAGGGGTGC AGCCAGCCTG CTCCGAGCTC CCCTGCAGAT GGAGGAGGCC 
ATCCTGGTCC CCTGCGTGCT GGGGCTCCTG CTGCTGCCCA TCCTGGCCAT GTTGATGGCA 
CTGTGTGTGC ACTGCCACAG ACTGCCAGGC TCCTACGACA GCACATCCTC AGATAGTTTG 
TATCCAAGGG GCATCCAGTT CAAACGGCCT CACACGGTTG CCCCCTGGCC ACCTGCCTAC 
CCACCTGTCA CCTCCTACCC ACCCCTGAGC CAGCCAGACC TGCTCCCCAT CCCAAGATCC 
CCGCAGCCCC TTGGGGGCTC CCACCGGACG CCATCTTCCC GGCGGGATTC TGATGGTGCC 
AACAGTGTGG CGAGCTACGA GAACGAGGAA CCAGCCTGTG AGGATGCGGA TGAGGATGAG 
GACGACTATC ACAACCCAGG CTACCTGGTG GTGCTTCCTG ACAGCACCCC GGCCACTAGC 
ACTGCTGCCC CATCAGCTCC TGCACTCAGC ACCCCTGGCA TCCGAGACAG TGCCTTCTCC 
ATGGAGTCCA TTGATGATTA CGTGAACGTT CCGGAGAGCG GGGAGAGCGC AGAAGCGTCT 
CTGGATGGCA GCCGGGAGTA TGTGAATGTG TCCCAGGAAC TGCATCCTGG AGCGGCTAAG 
ACTGAGCCTG CCGCCCTGAG TTCCCAGGAG GCAGAGGAAG TGGAGGAAGA GGGGGCTCCA 
GATTACGAGA ATCTGCAGGA GCTGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014989.2
CDS	60..869
Translation	MEATAASWQVAVPVLGGASRPLGPRGAASLLRAPLQMEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN

Target ORF information:

RefSeq Version	NM_001014989.2
Organism	Homo sapiens(human)
Definition	Homo sapiens linker for activation of T cells (LAT), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014989.2

ORF Insert Sequence:

ATGGAGGCCA CGGCTGCCAG CTGGCAGGTG GCTGTCCCCG TCTTGGGGGG GGCCAGCAGA 
CCCTTGGGGC CTAGGGGTGC AGCCAGCCTG CTCCGAGCTC CCCTGCAGAT GGAGGAGGCC 
ATCCTGGTCC CCTGCGTGCT GGGGCTCCTG CTGCTGCCCA TCCTGGCCAT GTTGATGGCA 
CTGTGTGTGC ACTGCCACAG ACTGCCAGGC TCCTACGACA GCACATCCTC AGATAGTTTG 
TATCCAAGGG GCATCCAGTT CAAACGGCCT CACACGGTTG CCCCCTGGCC ACCTGCCTAC 
CCACCTGTCA CCTCCTACCC ACCCCTGAGC CAGCCAGACC TGCTCCCCAT CCCAAGATCC 
CCGCAGCCCC TTGGGGGCTC CCACCGGACG CCATCTTCCC GGCGGGATTC TGATGGTGCC 
AACAGTGTGG CGAGCTACGA GAACGAGGAA CCAGCCTGTG AGGATGCGGA TGAGGATGAG 
GACGACTATC ACAACCCAGG CTACCTGGTG GTGCTTCCTG ACAGCACCCC GGCCACTAGC 
ACTGCTGCCC CATCAGCTCC TGCACTCAGC ACCCCTGGCA TCCGAGACAG TGCCTTCTCC 
ATGGAGTCCA TTGATGATTA CGTGAACGTT CCGGAGAGCG GGGAGAGCGC AGAAGCGTCT 
CTGGATGGCA GCCGGGAGTA TGTGAATGTG TCCCAGGAAC TGCATCCTGG AGCGGCTAAG 
ACTGAGCCTG CCGCCCTGAG TTCCCAGGAG GCAGAGGAAG TGGAGGAAGA GGGGGCTCCA 
GATTACGAGA ATCTGCAGGA GCTGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAT ( NM_001014988.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001014988.1 Homo sapiens linker for activation of T cells (LAT), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu17129
Clone ID Related Accession (Same CDS sequence)	NM_001014988.1 , NM_001014988.2
Accession Version	NM_001014988.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-22
Organism	Homo sapiens(human)
Product	linker for activation of T-cells family member 1 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI769296.1, BI911769.1, AJ223280.1 and BC011563.1. Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 4. The resulting isoform (c) is shorter at the N- terminus and lacks an internal aa compared to isoform d. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.304813.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGAGG CCATCCTGGT CCCCTGCGTG CTGGGGCTCC TGCTGCTGCC CATCCTGGCC 
ATGTTGATGG CACTGTGTGT GCACTGCCAC AGACTGCCAG GCTCCTACGA CAGCACATCC 
TCAGATAGTT TGTATCCAAG GGGCATCCAG TTCAAACGGC CTCACACGGT TGCCCCCTGG 
CCACCTGCCT ACCCACCTGT CACCTCCTAC CCACCCCTGA GCCAGCCAGA CCTGCTCCCC 
ATCCCATCCC CGCAGCCCCT TGGGGGCTCC CACCGGACGC CATCTTCCCG GCGGGATTCT 
GATGGTGCCA ACAGTGTGGC GAGCTACGAG AACGAGGAAC CAGCCTGTGA GGATGCGGAT 
GAGGATGAGG ACGACTATCA CAACCCAGGC TACCTGGTGG TGCTTCCTGA CAGCACCCCG 
GCCACTAGCA CTGCTGCCCC ATCAGCTCCT GCACTCAGCA CCCCTGGCAT CCGAGACAGT 
GCCTTCTCCA TGGAGTCCAT TGATGATTAC GTGAACGTTC CGGAGAGCGG GGAGAGCGCA 
GAAGCGTCTC TGGATGGCAG CCGGGAGTAT GTGAATGTGT CCCAGGAACT GCATCCTGGA 
GCGGCTAAGA CTGAGCCTGC CGCCCTGAGT TCCCAGGAGG CAGAGGAAGT GGAGGAAGAG 
GGGGCTCCAG ATTACGAGAA TCTGCAGGAG CTGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014988.1
CDS	353..1051
Translation	MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPSPQPLGGSHRTPSSRRDSDGANSVASYENEEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN

Target ORF information:

RefSeq Version	NM_001014988.1
Organism	Homo sapiens(human)
Definition	Homo sapiens linker for activation of T cells (LAT), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014988.1

ORF Insert Sequence:

ATGGAGGAGG CCATCCTGGT CCCCTGCGTG CTGGGGCTCC TGCTGCTGCC CATCCTGGCC 
ATGTTGATGG CACTGTGTGT GCACTGCCAC AGACTGCCAG GCTCCTACGA CAGCACATCC 
TCAGATAGTT TGTATCCAAG GGGCATCCAG TTCAAACGGC CTCACACGGT TGCCCCCTGG 
CCACCTGCCT ACCCACCTGT CACCTCCTAC CCACCCCTGA GCCAGCCAGA CCTGCTCCCC 
ATCCCATCCC CGCAGCCCCT TGGGGGCTCC CACCGGACGC CATCTTCCCG GCGGGATTCT 
GATGGTGCCA ACAGTGTGGC GAGCTACGAG AACGAGGAAC CAGCCTGTGA GGATGCGGAT 
GAGGATGAGG ACGACTATCA CAACCCAGGC TACCTGGTGG TGCTTCCTGA CAGCACCCCG 
GCCACTAGCA CTGCTGCCCC ATCAGCTCCT GCACTCAGCA CCCCTGGCAT CCGAGACAGT 
GCCTTCTCCA TGGAGTCCAT TGATGATTAC GTGAACGTTC CGGAGAGCGG GGAGAGCGCA 
GAAGCGTCTC TGGATGGCAG CCGGGAGTAT GTGAATGTGT CCCAGGAACT GCATCCTGGA 
GCGGCTAAGA CTGAGCCTGC CGCCCTGAGT TCCCAGGAGG CAGAGGAAGT GGAGGAAGAG 
GGGGCTCCAG ATTACGAGAA TCTGCAGGAG CTGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAT ( NM_001014988.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001014988.1 Homo sapiens linker for activation of T cells (LAT), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu17129
Clone ID Related Accession (Same CDS sequence)	NM_001014988.1 , NM_001014988.2
Accession Version	NM_001014988.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	linker for activation of T-cells family member 1 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC109460.3, BI769296.1, BI911769.1, AJ223280.1 and BC011563.1. On Jun 2, 2019 this sequence version replaced NM_001014988.1. Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 4. The resulting isoform (c) is shorter at the N- terminus and lacks an internal aa compared to isoform d. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.304813.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGAGG CCATCCTGGT CCCCTGCGTG CTGGGGCTCC TGCTGCTGCC CATCCTGGCC 
ATGTTGATGG CACTGTGTGT GCACTGCCAC AGACTGCCAG GCTCCTACGA CAGCACATCC 
TCAGATAGTT TGTATCCAAG GGGCATCCAG TTCAAACGGC CTCACACGGT TGCCCCCTGG 
CCACCTGCCT ACCCACCTGT CACCTCCTAC CCACCCCTGA GCCAGCCAGA CCTGCTCCCC 
ATCCCATCCC CGCAGCCCCT TGGGGGCTCC CACCGGACGC CATCTTCCCG GCGGGATTCT 
GATGGTGCCA ACAGTGTGGC GAGCTACGAG AACGAGGAAC CAGCCTGTGA GGATGCGGAT 
GAGGATGAGG ACGACTATCA CAACCCAGGC TACCTGGTGG TGCTTCCTGA CAGCACCCCG 
GCCACTAGCA CTGCTGCCCC ATCAGCTCCT GCACTCAGCA CCCCTGGCAT CCGAGACAGT 
GCCTTCTCCA TGGAGTCCAT TGATGATTAC GTGAACGTTC CGGAGAGCGG GGAGAGCGCA 
GAAGCGTCTC TGGATGGCAG CCGGGAGTAT GTGAATGTGT CCCAGGAACT GCATCCTGGA 
GCGGCTAAGA CTGAGCCTGC CGCCCTGAGT TCCCAGGAGG CAGAGGAAGT GGAGGAAGAG 
GGGGCTCCAG ATTACGAGAA TCTGCAGGAG CTGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014988.1
CDS	367..1065
Translation	MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPSPQPLGGSHRTPSSRRDSDGANSVASYENEEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN

Target ORF information:

RefSeq Version	NM_001014988.2
Organism	Homo sapiens(human)
Definition	Homo sapiens linker for activation of T cells (LAT), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014988.2

ORF Insert Sequence:

ATGGAGGAGG CCATCCTGGT CCCCTGCGTG CTGGGGCTCC TGCTGCTGCC CATCCTGGCC 
ATGTTGATGG CACTGTGTGT GCACTGCCAC AGACTGCCAG GCTCCTACGA CAGCACATCC 
TCAGATAGTT TGTATCCAAG GGGCATCCAG TTCAAACGGC CTCACACGGT TGCCCCCTGG 
CCACCTGCCT ACCCACCTGT CACCTCCTAC CCACCCCTGA GCCAGCCAGA CCTGCTCCCC 
ATCCCATCCC CGCAGCCCCT TGGGGGCTCC CACCGGACGC CATCTTCCCG GCGGGATTCT 
GATGGTGCCA ACAGTGTGGC GAGCTACGAG AACGAGGAAC CAGCCTGTGA GGATGCGGAT 
GAGGATGAGG ACGACTATCA CAACCCAGGC TACCTGGTGG TGCTTCCTGA CAGCACCCCG 
GCCACTAGCA CTGCTGCCCC ATCAGCTCCT GCACTCAGCA CCCCTGGCAT CCGAGACAGT 
GCCTTCTCCA TGGAGTCCAT TGATGATTAC GTGAACGTTC CGGAGAGCGG GGAGAGCGCA 
GAAGCGTCTC TGGATGGCAG CCGGGAGTAT GTGAATGTGT CCCAGGAACT GCATCCTGGA 
GCGGCTAAGA CTGAGCCTGC CGCCCTGAGT TCCCAGGAGG CAGAGGAAGT GGAGGAAGAG 
GGGGCTCCAG ATTACGAGAA TCTGCAGGAG CTGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAT ( NM_014387.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055202.1 Homo sapiens linker for activation of T cells (LAT), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17155
Clone ID Related Accession (Same CDS sequence)	NM_014387.4 , NM_014387.3
Accession Version	NM_014387.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	linker for activation of T-cells family member 1 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC109460.3, BI769296.1, AJ223280.1, AF036906.1 and BC011563.1. On Jun 2, 2019 this sequence version replaced NM_014387.3. Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence and contains an internal in-frame segment compared to variant 4. The resulting isoform (a) is shorter at the N-terminus and contains an internal segment compared to isoform d. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF036906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGAGG CCATCCTGGT CCCCTGCGTG CTGGGGCTCC TGCTGCTGCC CATCCTGGCC 
ATGTTGATGG CACTGTGTGT GCACTGCCAC AGACTGCCAG GCTCCTACGA CAGCACATCC 
TCAGATAGTT TGTATCCAAG GGGCATCCAG TTCAAACGGC CTCACACGGT TGCCCCCTGG 
CCACCTGCCT ACCCACCTGT CACCTCCTAC CCACCCCTGA GCCAGCCAGA CCTGCTCCCC 
ATCCCAAGAT CCCCGCAGCC CCTTGGGGGC TCCCACCGGA CGCCATCTTC CCGGCGGGAT 
TCTGATGGTG CCAACAGTGT GGCGAGCTAC GAGAACGAGG GTGCGTCTGG GATCCGAGGT 
GCCCAGGCTG GGTGGGGAGT CTGGGGTCCG TCCTGGACTA GGCTGACCCC TGTGTCGTTA 
CCCCCAGAAC CAGCCTGTGA GGATGCGGAT GAGGATGAGG ACGACTATCA CAACCCAGGC 
TACCTGGTGG TGCTTCCTGA CAGCACCCCG GCCACTAGCA CTGCTGCCCC ATCAGCTCCT 
GCACTCAGCA CCCCTGGCAT CCGAGACAGT GCCTTCTCCA TGGAGTCCAT TGATGATTAC 
GTGAACGTTC CGGAGAGCGG GGAGAGCGCA GAAGCGTCTC TGGATGGCAG CCGGGAGTAT 
GTGAATGTGT CCCAGGAACT GCATCCTGGA GCGGCTAAGA CTGAGCCTGC CGCCCTGAGT 
TCCCAGGAGG CAGAGGAAGT GGAGGAAGAG GGGGCTCCAG ATTACGAGAA TCTGCAGGAG 
CTGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055202.1
CDS	367..1155
Translation	MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEGASGIRGAQAGWGVWGPSWTRLTPVSLPPEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN

Target ORF information:

RefSeq Version	NM_014387.4
Organism	Homo sapiens(human)
Definition	Homo sapiens linker for activation of T cells (LAT), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014387.4

ORF Insert Sequence:

ATGGAGGAGG CCATCCTGGT CCCCTGCGTG CTGGGGCTCC TGCTGCTGCC CATCCTGGCC 
ATGTTGATGG CACTGTGTGT GCACTGCCAC AGACTGCCAG GCTCCTACGA CAGCACATCC 
TCAGATAGTT TGTATCCAAG GGGCATCCAG TTCAAACGGC CTCACACGGT TGCCCCCTGG 
CCACCTGCCT ACCCACCTGT CACCTCCTAC CCACCCCTGA GCCAGCCAGA CCTGCTCCCC 
ATCCCAAGAT CCCCGCAGCC CCTTGGGGGC TCCCACCGGA CGCCATCTTC CCGGCGGGAT 
TCTGATGGTG CCAACAGTGT GGCGAGCTAC GAGAACGAGG GTGCGTCTGG GATCCGAGGT 
GCCCAGGCTG GGTGGGGAGT CTGGGGTCCG TCCTGGACTA GGCTGACCCC TGTGTCGTTA 
CCCCCAGAAC CAGCCTGTGA GGATGCGGAT GAGGATGAGG ACGACTATCA CAACCCAGGC 
TACCTGGTGG TGCTTCCTGA CAGCACCCCG GCCACTAGCA CTGCTGCCCC ATCAGCTCCT 
GCACTCAGCA CCCCTGGCAT CCGAGACAGT GCCTTCTCCA TGGAGTCCAT TGATGATTAC 
GTGAACGTTC CGGAGAGCGG GGAGAGCGCA GAAGCGTCTC TGGATGGCAG CCGGGAGTAT 
GTGAATGTGT CCCAGGAACT GCATCCTGGA GCGGCTAAGA CTGAGCCTGC CGCCCTGAGT 
TCCCAGGAGG CAGAGGAAGT GGAGGAAGAG GGGGCTCCAG ATTACGAGAA TCTGCAGGAG 
CTGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAT ( NM_014387.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055202.1 Homo sapiens linker for activation of T cells (LAT), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17155
Clone ID Related Accession (Same CDS sequence)	NM_014387.4 , NM_014387.3
Accession Version	NM_014387.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	linker for activation of T-cells family member 1 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI769296.1, AJ223280.1, AF036906.1 and BC011563.1. On Apr 19, 2005 this sequence version replaced NM_014387.2. Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence and contains an internal in-frame segment compared to variant 4. The resulting isoform (a) is shorter at the N-terminus and contains an internal segment compared to isoform d. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF036906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGAGG CCATCCTGGT CCCCTGCGTG CTGGGGCTCC TGCTGCTGCC CATCCTGGCC 
ATGTTGATGG CACTGTGTGT GCACTGCCAC AGACTGCCAG GCTCCTACGA CAGCACATCC 
TCAGATAGTT TGTATCCAAG GGGCATCCAG TTCAAACGGC CTCACACGGT TGCCCCCTGG 
CCACCTGCCT ACCCACCTGT CACCTCCTAC CCACCCCTGA GCCAGCCAGA CCTGCTCCCC 
ATCCCAAGAT CCCCGCAGCC CCTTGGGGGC TCCCACCGGA CGCCATCTTC CCGGCGGGAT 
TCTGATGGTG CCAACAGTGT GGCGAGCTAC GAGAACGAGG GTGCGTCTGG GATCCGAGGT 
GCCCAGGCTG GGTGGGGAGT CTGGGGTCCG TCCTGGACTA GGCTGACCCC TGTGTCGTTA 
CCCCCAGAAC CAGCCTGTGA GGATGCGGAT GAGGATGAGG ACGACTATCA CAACCCAGGC 
TACCTGGTGG TGCTTCCTGA CAGCACCCCG GCCACTAGCA CTGCTGCCCC ATCAGCTCCT 
GCACTCAGCA CCCCTGGCAT CCGAGACAGT GCCTTCTCCA TGGAGTCCAT TGATGATTAC 
GTGAACGTTC CGGAGAGCGG GGAGAGCGCA GAAGCGTCTC TGGATGGCAG CCGGGAGTAT 
GTGAATGTGT CCCAGGAACT GCATCCTGGA GCGGCTAAGA CTGAGCCTGC CGCCCTGAGT 
TCCCAGGAGG CAGAGGAAGT GGAGGAAGAG GGGGCTCCAG ATTACGAGAA TCTGCAGGAG 
CTGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055202.1
CDS	353..1141
Translation	MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEGASGIRGAQAGWGVWGPSWTRLTPVSLPPEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN

Target ORF information:

RefSeq Version	NM_014387.3
Organism	Homo sapiens(human)
Definition	Homo sapiens linker for activation of T cells (LAT), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014387.3

ORF Insert Sequence:

ATGGAGGAGG CCATCCTGGT CCCCTGCGTG CTGGGGCTCC TGCTGCTGCC CATCCTGGCC 
ATGTTGATGG CACTGTGTGT GCACTGCCAC AGACTGCCAG GCTCCTACGA CAGCACATCC 
TCAGATAGTT TGTATCCAAG GGGCATCCAG TTCAAACGGC CTCACACGGT TGCCCCCTGG 
CCACCTGCCT ACCCACCTGT CACCTCCTAC CCACCCCTGA GCCAGCCAGA CCTGCTCCCC 
ATCCCAAGAT CCCCGCAGCC CCTTGGGGGC TCCCACCGGA CGCCATCTTC CCGGCGGGAT 
TCTGATGGTG CCAACAGTGT GGCGAGCTAC GAGAACGAGG GTGCGTCTGG GATCCGAGGT 
GCCCAGGCTG GGTGGGGAGT CTGGGGTCCG TCCTGGACTA GGCTGACCCC TGTGTCGTTA 
CCCCCAGAAC CAGCCTGTGA GGATGCGGAT GAGGATGAGG ACGACTATCA CAACCCAGGC 
TACCTGGTGG TGCTTCCTGA CAGCACCCCG GCCACTAGCA CTGCTGCCCC ATCAGCTCCT 
GCACTCAGCA CCCCTGGCAT CCGAGACAGT GCCTTCTCCA TGGAGTCCAT TGATGATTAC 
GTGAACGTTC CGGAGAGCGG GGAGAGCGCA GAAGCGTCTC TGGATGGCAG CCGGGAGTAT 
GTGAATGTGT CCCAGGAACT GCATCCTGGA GCGGCTAAGA CTGAGCCTGC CGCCCTGAGT 
TCCCAGGAGG CAGAGGAAGT GGAGGAAGAG GGGGCTCCAG ATTACGAGAA TCTGCAGGAG 
CTGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dynamic Scaling Analysis of Molecular Motion within the LAT:Grb2:SOS Protein Network on?Membranes.
Biophysical journal113(8)1807-1813(2017 Oct)
Huang WYC,Chiang HK,Groves JT

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LAT cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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