AMPD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AMPD1
Entrez Gene ID	270
Full Name	adenosine monophosphate deaminase 1
Synonyms	MAD,MADA,MMDD
General protein information	Preferred Names adenosine monophosphate deaminase 1 Names AMP deaminase 1 AMPD adenosine monophosphate deaminase 1 (isoform M) adenosine monophosphate deaminase-1 (muscle) myoadenylate deaminase skeletal muscle AMPD
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p13.2
Summary	Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010].
Disorder MIM:	102770
Disorder Html:	Myopathy due to myoadenylate deaminase deficiency, 615511 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001172626.1	NP_001166097.1	AMP deaminase 1 isoform 2
NM_000036.2	NP_000027.2	AMP deaminase 1 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	AMPD1	NP_000027.2
Danio rerio (zebrafish)	ampd1	NP_957187.1
	AMPD1	XP_001111578.2
Xenopus tropicalis (tropical clawed frog)	ampd1	XP_002935821.2
Pan troglodytes (chimpanzee)	AMPD1	XP_513671.3
Mus musculus (house mouse)	Ampd1	NP_001028475.2
Gallus gallus (chicken)	AMPD1	XP_003642776.1
Bos taurus (cattle)	AMPD1	NP_001093819.1
Rattus norvegicus (Norway rat)	Ampd1	NP_620231.1
Canis lupus familiaris (dog)	AMPD1	XP_848536.2

Gene Ontology
Bibliography

Related articles in PubMed

Effects of AMPD1 gene C34T polymorphism on cardiac index, blood pressure and prognosis in patients with cardiovascular diseases: a meta-analysis.
Feng AF, Liu ZH, Zhou SL, Zhao SY, Zhu YX, Wang HX
BMC cardiovascular disorders17(1)174(2017 Jul)

Effects of AMPD1 common mutation on the metabolic-chronotropic relationship: Insights from patients with myoadenylate deaminase deficiency.
Rannou F, Scotet V, Marcorelles P, Monnoyer R, Le Mar?chal C
PloS one12(11)e0187266(2017)

Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome.
Maltese PE, Venturini L, Poplavskaya E, Bertelli M, Cecchin S, Granato M, Nikulina SY, Salmina A, Aksyutina N, Capelli E, Ricevuti G, Lorusso L
Genetics and molecular research : GMR15(3)(2016 Jul)

Association between the C34T polymorphism of the AMPD1 gene and essential hypertension in Malaysian patients.
Nemati R, Lu J, Ramachandran V, Etemad A, Heidari M, Yahya MJ, Roozafzoon R, Ismail P
Genetics and molecular research : GMR15(2)(2016 Jun)

Characterization of the human and rat myoadenylate deaminase genes.
Sabina RL, Morisaki T, Clarke P, Eddy R, Shows TB, Morton CC, Holmes EW
The Journal of biological chemistry265(16)9423-33(1990 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

T allele of AMPD1 gene C34T polymorphism may be correlated with LVEF, LVEDD and SBP, which plays a protective role in the cardiac functions and blood pressure in cardiovascular disease patients.
Title: Effects of AMPD1 gene C34T polymorphism on cardiac index, blood pressure and prognosis in patients with cardiovascular diseases: a meta-analysis.

The metabolic-chronotropic response is decreased in skeletal muscle MAD deficiency, suggesting a biological mechanism by which AMPD1 gene exerts cardiac effect
Title: Effects of AMPD1 common mutation on the metabolic-chronotropic relationship: Insights from patients with myoadenylate deaminase deficiency.

Variations in AMPD1, CPT2, and PGYM genes are not associated with the onset, susceptibility, or severity of chronic fatigue syndrome.
Title: Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome.

Common polymorphism of the AMPD1 gene (C34T) is strongly associated with essential hypertension.
Title: Association between the C34T polymorphism of the AMPD1 gene and essential hypertension in Malaysian patients.

AMPD1 34C>T variant is associated with higher infection susceptibility to community acquired pneumonia but not to ventilator associated pneumonia in sepsis pateints
Title: Effects of the 34C>T Variant of the AMPD1 Gene on Immune Function, Multi-Organ Dysfunction, and Mortality in Sepsis Patients.

The following AMPD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AMPD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu04499	NM_001172626.1 Latest version!	Homo sapiens adenosine monophosphate deaminase 1 (AMPD1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$389.50-$545.30 $779.00
OHu19364	NM_000036.2 Latest version!	Homo sapiens adenosine monophosphate deaminase 1 (AMPD1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$394.50-$552.30 $789.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AMPD1 ( NM_001172626.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001166097.1 Homo sapiens adenosine monophosphate deaminase 1 (AMPD1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04499
Clone ID Related Accession (Same CDS sequence)	NM_001172626.1
Accession Version	NM_001172626.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2331bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	AMP deaminase 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK097077.1, AK314252.1 and AA086476.1. Transcript Variant: This variant (2) lacks an in-frame coding exon in the 5' region, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK097077.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGAATGTCA GGATATTTTA TAGTGTCAGT CAGTCACCCC ACAGTCTCCT CTCTCTTCTT 
TTCTACTGTG CTATCCTAGA ATCAAGGATT TCAGCAACAA TGCCTCTGTT CAAACTCCCA 
GAAATTGATG ATGCAATGCG CAACTTTGCT GAAAAAGTGT TTGCCTCTGA AGTCAAAGAT 
GAAGGAGGTC GTCAGGAGAT TTCCCCCTTT GATGTGGATG AGATCTGTCC GATTTCTCAT 
CATGAGATGC AAGCACACAT ATTCCATCTG GAGACTCTGT CCACCTCCAC AGAAGCCAGG 
AGAAAAAAGC GTTTCCAAGG ACGGAAGACT GTTAATTTGT CCATTCCACT AAGTGAAACA 
TCTTCCACCA AACTGTCCCA CATTGATGAA TACATTTCCT CATCTCCAAC CTACCAGACC 
GTGCCTGATT TTCAGAGAGT GCAGATTACT GGTGACTATG CCTCTGGGGT TACAGTTGAA 
GATTTTGAAA TTGTTTGCAA AGGTCTGTAT CGGGCACTAT GCATACGTGA GAAATACATG 
CAGAAGTCGT TTCAGAGGTT CCCTAAAACC CCTTCCAAAT ACTTGCGGAA CATTGATGGT 
GAGGCTTGGG TAGCAAATGA GAGCTTCTAT CCAGTCTTTA CTCCTCCTGT GAAGAAGGGA 
GAGGACCCCT TCCGAACAGA CAACCTTCCT GAAAACCTGG GCTATCACCT CAAAATGAAG 
GACGGTGTAG TTTACGTCTA TCCTAATGAA GCAGCAGTCA GCAAAGATGA GCCTAAGCCA 
CTTCCTTACC CAAATCTGGA CACCTTCTTA GACGATATGA ATTTTTTACT TGCTTTAATT 
GCTCAAGGAC CTGTTAAGAC CTATACCCAC CGGCGCCTGA AGTTCCTCTC CTCCAAGTTC 
CAGGTCCATC AGATGCTTAA CGAGATGGAC GAGTTAAAGG AGCTGAAAAA CAACCCCCAC 
CGAGATTTTT ATAACTGCAG GAAGGTGGAC ACCCATATCC ATGCAGCCGC TTGCATGAAC 
CAGAAACATC TGCTGCGTTT TATTAAGAAA TCTTACCAAA TTGATGCTGA CAGAGTGGTC 
TATAGCACCA AAGAGAAGAA TCTGACCCTA AAGGAACTTT TTGCTAAATT AAAAATGCAT 
CCTTATGACC TGACTGTTGA TTCTCTGGAT GTTCATGCTG GACGCCAGAC CTTCCAGCGT 
TTTGATAAGT TCAATGACAA ATATAATCCT GTAGGAGCAA GTGAGCTACG GGACCTCTAC 
TTGAAGACAG ACAATTACAT TAATGGGGAA TATTTTGCCA CTATCATCAA GGAGGTAGGT 
GCGGACCTGG TGGAGGCCAA GTACCAGCAT GCTGAGCCCC GCCTGTCCAT CTATGGCCGC 
AGTCCTGATG AGTGGAGCAA ACTCTCCTCC TGGTTCGTCT GCAATCGCAT CCACTGCCCC 
AACATGACAT GGATGATCCA GGTTCCCAGG ATCTATGATG TGTTCCGTTC CAAGAATTTC 
CTTCCACATT TTGGAAAAAT GCTGGAGAAT ATTTTCATGC CAGTGTTTGA GGCCACCATC 
AACCCCCAGG CTGACCCAGA ACTCAGTGTC TTCCTCAAGC ATATCACTGG CTTTGACAGT 
GTGGATGATG AGTCCAAACA CAGTGGCCAC ATGTTCTCCT CCAAGAGTCC CAAGCCCCAG 
GAGTGGACAT TGGAAAAGAA TCCATCTTAC ACTTACTATG CCTACTACAT GTATGCAAAC 
ATCATGGTGC TCAACAGCCT GAGAAAGGAA CGAGGCATGA ATACGTTTCT GTTCCGACCT 
CACTGTGGAG AAGCTGGAGC CCTCACCCAT CTCATGACAG CATTCATGAT AGCAGATGAT 
ATCTCTCATG GCCTAAATTT AAAAAAGAGT CCCGTGCTAC AGTACTTGTT TTTCTTAGCC 
CAAATTCCCA TCGCCATGTC ACCACTAAGT AACAATAGCC TATTTCTAGA GTATGCCAAA 
AATCCTTTTT TGGATTTCCT TCAGAAAGGG CTAATGATCT CACTGTCTAC AGATGACCCA 
ATGCAATTCC ACTTTACCAA GGAGCCCCTA ATGGAAGAAT ATGCTATTGC TGCACAAGTC 
TTCAAGCTGA GCACCTGTGA TATGTGCGAA GTGGCAAGGA ACAGTGTCTT GCAGTGTGGA 
ATTTCTCATG AGGAGAAAGT AAAGTTTCTG GGCGACAATT ACCTTGAGGA AGGCCCTGCT 
GGAAATGATA TCCGGAGGAC AAATGTAGCC CAAATCCGCA TGGCCTATCG CTATGAAACC 
TGGTGTTATG AACTCAATTT AATTGCTGAG GGTCTTAAAT CAACAGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166097.1
CDS	49..2379
Translation	MNVRIFYSVSQSPHSLLSLLFYCAILESRISATMPLFKLPEIDDAMRNFAEKVFASEVKDEGGRQEISPFDVDEICPISHHEMQAHIFHLETLSTSTEARRKKRFQGRKTVNLSIPLSETSSTKLSHIDEYISSSPTYQTVPDFQRVQITGDYASGVTVEDFEIVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEAWVANESFYPVFTPPVKKGEDPFRTDNLPENLGYHLKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTFLDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKVDTHIHAAACMNQKHLLRFIKKSYQIDADRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSLDVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVEAKYQHAEPRLSIYGRSPDEWSKLSSWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFMPVFEATINPQADPELSVFLKHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPSYTYYAYYMYANIMVLNSLRKERGMNTFLFRPHCGEAGALTHLMTAFMIADDISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNVAQIRMAYRYETWCYELNLIAEGLKSTE

Target ORF information:

RefSeq Version	NM_001172626.1
Organism	Homo sapiens(human)
Definition	Homo sapiens adenosine monophosphate deaminase 1 (AMPD1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001172626.1

ORF Insert Sequence:

ATGAATGTCA GGATATTTTA TAGTGTCAGT CAGTCACCCC ACAGTCTCCT CTCTCTTCTT 
TTCTACTGTG CTATCCTAGA ATCAAGGATT TCAGCAACAA TGCCTCTGTT CAAACTCCCA 
GAAATTGATG ATGCAATGCG CAACTTTGCT GAAAAAGTGT TTGCCTCTGA AGTCAAAGAT 
GAAGGAGGTC GTCAGGAGAT TTCCCCCTTT GATGTGGATG AGATCTGTCC GATTTCTCAT 
CATGAGATGC AAGCACACAT ATTCCATCTG GAGACTCTGT CCACCTCCAC AGAAGCCAGG 
AGAAAAAAGC GTTTCCAAGG ACGGAAGACT GTTAATTTGT CCATTCCACT AAGTGAAACA 
TCTTCCACCA AACTGTCCCA CATTGATGAA TACATTTCCT CATCTCCAAC CTACCAGACC 
GTGCCTGATT TTCAGAGAGT GCAGATTACT GGTGACTATG CCTCTGGGGT TACAGTTGAA 
GATTTTGAAA TTGTTTGCAA AGGTCTGTAT CGGGCACTAT GCATACGTGA GAAATACATG 
CAGAAGTCGT TTCAGAGGTT CCCTAAAACC CCTTCCAAAT ACTTGCGGAA CATTGATGGT 
GAGGCTTGGG TAGCAAATGA GAGCTTCTAT CCAGTCTTTA CTCCTCCTGT GAAGAAGGGA 
GAGGACCCCT TCCGAACAGA CAACCTTCCT GAAAACCTGG GCTATCACCT CAAAATGAAG 
GACGGTGTAG TTTACGTCTA TCCTAATGAA GCAGCAGTCA GCAAAGATGA GCCTAAGCCA 
CTTCCTTACC CAAATCTGGA CACCTTCTTA GACGATATGA ATTTTTTACT TGCTTTAATT 
GCTCAAGGAC CTGTTAAGAC CTATACCCAC CGGCGCCTGA AGTTCCTCTC CTCCAAGTTC 
CAGGTCCATC AGATGCTTAA CGAGATGGAC GAGTTAAAGG AGCTGAAAAA CAACCCCCAC 
CGAGATTTTT ATAACTGCAG GAAGGTGGAC ACCCATATCC ATGCAGCCGC TTGCATGAAC 
CAGAAACATC TGCTGCGTTT TATTAAGAAA TCTTACCAAA TTGATGCTGA CAGAGTGGTC 
TATAGCACCA AAGAGAAGAA TCTGACCCTA AAGGAACTTT TTGCTAAATT AAAAATGCAT 
CCTTATGACC TGACTGTTGA TTCTCTGGAT GTTCATGCTG GACGCCAGAC CTTCCAGCGT 
TTTGATAAGT TCAATGACAA ATATAATCCT GTAGGAGCAA GTGAGCTACG GGACCTCTAC 
TTGAAGACAG ACAATTACAT TAATGGGGAA TATTTTGCCA CTATCATCAA GGAGGTAGGT 
GCGGACCTGG TGGAGGCCAA GTACCAGCAT GCTGAGCCCC GCCTGTCCAT CTATGGCCGC 
AGTCCTGATG AGTGGAGCAA ACTCTCCTCC TGGTTCGTCT GCAATCGCAT CCACTGCCCC 
AACATGACAT GGATGATCCA GGTTCCCAGG ATCTATGATG TGTTCCGTTC CAAGAATTTC 
CTTCCACATT TTGGAAAAAT GCTGGAGAAT ATTTTCATGC CAGTGTTTGA GGCCACCATC 
AACCCCCAGG CTGACCCAGA ACTCAGTGTC TTCCTCAAGC ATATCACTGG CTTTGACAGT 
GTGGATGATG AGTCCAAACA CAGTGGCCAC ATGTTCTCCT CCAAGAGTCC CAAGCCCCAG 
GAGTGGACAT TGGAAAAGAA TCCATCTTAC ACTTACTATG CCTACTACAT GTATGCAAAC 
ATCATGGTGC TCAACAGCCT GAGAAAGGAA CGAGGCATGA ATACGTTTCT GTTCCGACCT 
CACTGTGGAG AAGCTGGAGC CCTCACCCAT CTCATGACAG CATTCATGAT AGCAGATGAT 
ATCTCTCATG GCCTAAATTT AAAAAAGAGT CCCGTGCTAC AGTACTTGTT TTTCTTAGCC 
CAAATTCCCA TCGCCATGTC ACCACTAAGT AACAATAGCC TATTTCTAGA GTATGCCAAA 
AATCCTTTTT TGGATTTCCT TCAGAAAGGG CTAATGATCT CACTGTCTAC AGATGACCCA 
ATGCAATTCC ACTTTACCAA GGAGCCCCTA ATGGAAGAAT ATGCTATTGC TGCACAAGTC 
TTCAAGCTGA GCACCTGTGA TATGTGCGAA GTGGCAAGGA ACAGTGTCTT GCAGTGTGGA 
ATTTCTCATG AGGAGAAAGT AAAGTTTCTG GGCGACAATT ACCTTGAGGA AGGCCCTGCT 
GGAAATGATA TCCGGAGGAC AAATGTAGCC CAAATCCGCA TGGCCTATCG CTATGAAACC 
TGGTGTTATG AACTCAATTT AATTGCTGAG GGTCTTAAAT CAACAGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AMPD1 ( NM_000036.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000027.2 Homo sapiens adenosine monophosphate deaminase 1 (AMPD1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19364
Clone ID Related Accession (Same CDS sequence)	NM_000036.2
Accession Version	NM_000036.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2343bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	AMP deaminase 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK097077.1, M60092.1 and AA086476.1. This sequence is a reference standard in the RefSeqGene project. On Feb 24, 2010 this sequence version replaced NM_000036.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M60092.1, AK291349.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGAATGTCA GGATATTTTA TAGTGTCAGT CAGTCACCCC ACAGTCTCCT CTCTCTTCTT 
TTCTACTGTG CTATCCTAGA ATCAAGGATT TCAGCAACAA TGCCTCTGTT CAAACTCCCA 
GCTGAAGAGA AACAAATTGA TGATGCAATG CGCAACTTTG CTGAAAAAGT GTTTGCCTCT 
GAAGTCAAAG ATGAAGGAGG TCGTCAGGAG ATTTCCCCCT TTGATGTGGA TGAGATCTGT 
CCGATTTCTC ATCATGAGAT GCAAGCACAC ATATTCCATC TGGAGACTCT GTCCACCTCC 
ACAGAAGCCA GGAGAAAAAA GCGTTTCCAA GGACGGAAGA CTGTTAATTT GTCCATTCCA 
CTAAGTGAAA CATCTTCCAC CAAACTGTCC CACATTGATG AATACATTTC CTCATCTCCA 
ACCTACCAGA CCGTGCCTGA TTTTCAGAGA GTGCAGATTA CTGGTGACTA TGCCTCTGGG 
GTTACAGTTG AAGATTTTGA AATTGTTTGC AAAGGTCTGT ATCGGGCACT ATGCATACGT 
GAGAAATACA TGCAGAAGTC GTTTCAGAGG TTCCCTAAAA CCCCTTCCAA ATACTTGCGG 
AACATTGATG GTGAGGCTTG GGTAGCAAAT GAGAGCTTCT ATCCAGTCTT TACTCCTCCT 
GTGAAGAAGG GAGAGGACCC CTTCCGAACA GACAACCTTC CTGAAAACCT GGGCTATCAC 
CTCAAAATGA AGGACGGTGT AGTTTACGTC TATCCTAATG AAGCAGCAGT CAGCAAAGAT 
GAGCCTAAGC CACTTCCTTA CCCAAATCTG GACACCTTCT TAGACGATAT GAATTTTTTA 
CTTGCTTTAA TTGCTCAAGG ACCTGTTAAG ACCTATACCC ACCGGCGCCT GAAGTTCCTC 
TCCTCCAAGT TCCAGGTCCA TCAGATGCTT AACGAGATGG ACGAGTTAAA GGAGCTGAAA 
AACAACCCCC ACCGAGATTT TTATAACTGC AGGAAGGTGG ACACCCATAT CCATGCAGCC 
GCTTGCATGA ACCAGAAACA TCTGCTGCGT TTTATTAAGA AATCTTACCA AATTGATGCT 
GACAGAGTGG TCTATAGCAC CAAAGAGAAG AATCTGACCC TAAAGGAACT TTTTGCTAAA 
TTAAAAATGC ATCCTTATGA CCTGACTGTT GATTCTCTGG ATGTTCATGC TGGACGCCAG 
ACCTTCCAGC GTTTTGATAA GTTCAATGAC AAATATAATC CTGTAGGAGC AAGTGAGCTA 
CGGGACCTCT ACTTGAAGAC AGACAATTAC ATTAATGGGG AATATTTTGC CACTATCATC 
AAGGAGGTAG GTGCGGACCT GGTGGAGGCC AAGTACCAGC ATGCTGAGCC CCGCCTGTCC 
ATCTATGGCC GCAGTCCTGA TGAGTGGAGC AAACTCTCCT CCTGGTTCGT CTGCAATCGC 
ATCCACTGCC CCAACATGAC ATGGATGATC CAGGTTCCCA GGATCTATGA TGTGTTCCGT 
TCCAAGAATT TCCTTCCACA TTTTGGAAAA ATGCTGGAGA ATATTTTCAT GCCAGTGTTT 
GAGGCCACCA TCAACCCCCA GGCTGACCCA GAACTCAGTG TCTTCCTCAA GCATATCACT 
GGCTTTGACA GTGTGGATGA TGAGTCCAAA CACAGTGGCC ACATGTTCTC CTCCAAGAGT 
CCCAAGCCCC AGGAGTGGAC ATTGGAAAAG AATCCATCTT ACACTTACTA TGCCTACTAC 
ATGTATGCAA ACATCATGGT GCTCAACAGC CTGAGAAAGG AACGAGGCAT GAATACGTTT 
CTGTTCCGAC CTCACTGTGG AGAAGCTGGA GCCCTCACCC ATCTCATGAC AGCATTCATG 
ATAGCAGATG ATATCTCTCA TGGCCTAAAT TTAAAAAAGA GTCCCGTGCT ACAGTACTTG 
TTTTTCTTAG CCCAAATTCC CATCGCCATG TCACCACTAA GTAACAATAG CCTATTTCTA 
GAGTATGCCA AAAATCCTTT TTTGGATTTC CTTCAGAAAG GGCTAATGAT CTCACTGTCT 
ACAGATGACC CAATGCAATT CCACTTTACC AAGGAGCCCC TAATGGAAGA ATATGCTATT 
GCTGCACAAG TCTTCAAGCT GAGCACCTGT GATATGTGCG AAGTGGCAAG GAACAGTGTC 
TTGCAGTGTG GAATTTCTCA TGAGGAGAAA GTAAAGTTTC TGGGCGACAA TTACCTTGAG 
GAAGGCCCTG CTGGAAATGA TATCCGGAGG ACAAATGTAG CCCAAATCCG CATGGCCTAT 
CGCTATGAAA CCTGGTGTTA TGAACTCAAT TTAATTGCTG AGGGTCTTAA ATCAACAGAA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000027.2
CDS	49..2391
Translation	MNVRIFYSVSQSPHSLLSLLFYCAILESRISATMPLFKLPAEEKQIDDAMRNFAEKVFASEVKDEGGRQEISPFDVDEICPISHHEMQAHIFHLETLSTSTEARRKKRFQGRKTVNLSIPLSETSSTKLSHIDEYISSSPTYQTVPDFQRVQITGDYASGVTVEDFEIVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEAWVANESFYPVFTPPVKKGEDPFRTDNLPENLGYHLKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTFLDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKVDTHIHAAACMNQKHLLRFIKKSYQIDADRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSLDVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVEAKYQHAEPRLSIYGRSPDEWSKLSSWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFMPVFEATINPQADPELSVFLKHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPSYTYYAYYMYANIMVLNSLRKERGMNTFLFRPHCGEAGALTHLMTAFMIADDISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNVAQIRMAYRYETWCYELNLIAEGLKSTE

Target ORF information:

RefSeq Version	NM_000036.2
Organism	Homo sapiens(human)
Definition	Homo sapiens adenosine monophosphate deaminase 1 (AMPD1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000036.2

ORF Insert Sequence:

ATGAATGTCA GGATATTTTA TAGTGTCAGT CAGTCACCCC ACAGTCTCCT CTCTCTTCTT 
TTCTACTGTG CTATCCTAGA ATCAAGGATT TCAGCAACAA TGCCTCTGTT CAAACTCCCA 
GCTGAAGAGA AACAAATTGA TGATGCAATG CGCAACTTTG CTGAAAAAGT GTTTGCCTCT 
GAAGTCAAAG ATGAAGGAGG TCGTCAGGAG ATTTCCCCCT TTGATGTGGA TGAGATCTGT 
CCGATTTCTC ATCATGAGAT GCAAGCACAC ATATTCCATC TGGAGACTCT GTCCACCTCC 
ACAGAAGCCA GGAGAAAAAA GCGTTTCCAA GGACGGAAGA CTGTTAATTT GTCCATTCCA 
CTAAGTGAAA CATCTTCCAC CAAACTGTCC CACATTGATG AATACATTTC CTCATCTCCA 
ACCTACCAGA CCGTGCCTGA TTTTCAGAGA GTGCAGATTA CTGGTGACTA TGCCTCTGGG 
GTTACAGTTG AAGATTTTGA AATTGTTTGC AAAGGTCTGT ATCGGGCACT ATGCATACGT 
GAGAAATACA TGCAGAAGTC GTTTCAGAGG TTCCCTAAAA CCCCTTCCAA ATACTTGCGG 
AACATTGATG GTGAGGCTTG GGTAGCAAAT GAGAGCTTCT ATCCAGTCTT TACTCCTCCT 
GTGAAGAAGG GAGAGGACCC CTTCCGAACA GACAACCTTC CTGAAAACCT GGGCTATCAC 
CTCAAAATGA AGGACGGTGT AGTTTACGTC TATCCTAATG AAGCAGCAGT CAGCAAAGAT 
GAGCCTAAGC CACTTCCTTA CCCAAATCTG GACACCTTCT TAGACGATAT GAATTTTTTA 
CTTGCTTTAA TTGCTCAAGG ACCTGTTAAG ACCTATACCC ACCGGCGCCT GAAGTTCCTC 
TCCTCCAAGT TCCAGGTCCA TCAGATGCTT AACGAGATGG ACGAGTTAAA GGAGCTGAAA 
AACAACCCCC ACCGAGATTT TTATAACTGC AGGAAGGTGG ACACCCATAT CCATGCAGCC 
GCTTGCATGA ACCAGAAACA TCTGCTGCGT TTTATTAAGA AATCTTACCA AATTGATGCT 
GACAGAGTGG TCTATAGCAC CAAAGAGAAG AATCTGACCC TAAAGGAACT TTTTGCTAAA 
TTAAAAATGC ATCCTTATGA CCTGACTGTT GATTCTCTGG ATGTTCATGC TGGACGCCAG 
ACCTTCCAGC GTTTTGATAA GTTCAATGAC AAATATAATC CTGTAGGAGC AAGTGAGCTA 
CGGGACCTCT ACTTGAAGAC AGACAATTAC ATTAATGGGG AATATTTTGC CACTATCATC 
AAGGAGGTAG GTGCGGACCT GGTGGAGGCC AAGTACCAGC ATGCTGAGCC CCGCCTGTCC 
ATCTATGGCC GCAGTCCTGA TGAGTGGAGC AAACTCTCCT CCTGGTTCGT CTGCAATCGC 
ATCCACTGCC CCAACATGAC ATGGATGATC CAGGTTCCCA GGATCTATGA TGTGTTCCGT 
TCCAAGAATT TCCTTCCACA TTTTGGAAAA ATGCTGGAGA ATATTTTCAT GCCAGTGTTT 
GAGGCCACCA TCAACCCCCA GGCTGACCCA GAACTCAGTG TCTTCCTCAA GCATATCACT 
GGCTTTGACA GTGTGGATGA TGAGTCCAAA CACAGTGGCC ACATGTTCTC CTCCAAGAGT 
CCCAAGCCCC AGGAGTGGAC ATTGGAAAAG AATCCATCTT ACACTTACTA TGCCTACTAC 
ATGTATGCAA ACATCATGGT GCTCAACAGC CTGAGAAAGG AACGAGGCAT GAATACGTTT 
CTGTTCCGAC CTCACTGTGG AGAAGCTGGA GCCCTCACCC ATCTCATGAC AGCATTCATG 
ATAGCAGATG ATATCTCTCA TGGCCTAAAT TTAAAAAAGA GTCCCGTGCT ACAGTACTTG 
TTTTTCTTAG CCCAAATTCC CATCGCCATG TCACCACTAA GTAACAATAG CCTATTTCTA 
GAGTATGCCA AAAATCCTTT TTTGGATTTC CTTCAGAAAG GGCTAATGAT CTCACTGTCT 
ACAGATGACC CAATGCAATT CCACTTTACC AAGGAGCCCC TAATGGAAGA ATATGCTATT 
GCTGCACAAG TCTTCAAGCT GAGCACCTGT GATATGTGCG AAGTGGCAAG GAACAGTGTC 
TTGCAGTGTG GAATTTCTCA TGAGGAGAAA GTAAAGTTTC TGGGCGACAA TTACCTTGAG 
GAAGGCCCTG CTGGAAATGA TATCCGGAGG ACAAATGTAG CCCAAATCCG CATGGCCTAT 
CGCTATGAAA CCTGGTGTTA TGAACTCAAT TTAATTGCTG AGGGTCTTAA ATCAACAGAA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effects of AMPD1 gene C34T polymorphism on cardiac index, blood pressure and prognosis in patients with cardiovascular diseases: a meta-analysis.
BMC cardiovascular disorders17(1)174(2017 Jul)
Feng AF,Liu ZH,Zhou SL,Zhao SY,Zhu YX,Wang HX

Effects of AMPD1 common mutation on the metabolic-chronotropic relationship: Insights from patients with myoadenylate deaminase deficiency.
PloS one12(11)e0187266(2017)
Rannou F,Scotet V,Marcorelles P,Monnoyer R,Le Mar?chal C

Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome.
Genetics and molecular research : GMR15(3)(2016 Jul)
Maltese PE,Venturini L,Poplavskaya E,Bertelli M,Cecchin S,Granato M,Nikulina SY,Salmina A,Aksyutina N,Capelli E,Ricevuti G,Lorusso L

Association between the C34T polymorphism of the AMPD1 gene and essential hypertension in Malaysian patients.
Genetics and molecular research : GMR15(2)(2016 Jun)
Nemati R,Lu J,Ramachandran V,Etemad A,Heidari M,Yahya MJ,Roozafzoon R,Ismail P

Characterization of the human and rat myoadenylate deaminase genes.
The Journal of biological chemistry265(16)9423-33(1990 Jun)
Sabina RL,Morisaki T,Clarke P,Eddy R,Shows TB,Morton CC,Holmes EW

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AMPD1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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