GDI1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GDI1
Entrez Gene ID	2664
Full Name	GDP dissociation inhibitor 1
Synonyms	1A,GDIL,MRX41,MRX48,OPHN2,RABGD1A,RABGDIA,XAP-4
General protein information	Preferred Names GDP dissociation inhibitor 1 Names rab GDP dissociation inhibitor alpha GDI-1 guanosine diphosphate dissociation inhibitor 1 mental retardation, X-linked 48 oligophrenin-2 protein XAP-4 rab GDI alpha rab GDP-dissociation inhibitor, alpha testis secretory sperm-binding protein Li 208a
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability. [provided by RefSeq, Jul 2008].
Disorder MIM:	300104
Disorder Html:	Mental retardation, X-linked 41, 300849 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001493.3	NP_001484.1	rab GDP dissociation inhibitor alpha
NM_001493.2	NP_001484.1	rab GDP dissociation inhibitor alpha

Pathways from BioSystems

Homologies

Homo sapiens (human)	GDI1	NP_001484.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010025	XP_319173.1
Eremothecium gossypii	AGOS_AFR183C	NP_985730.1
Mus musculus (house mouse)	Gdi1	NP_034403.1
Drosophila melanogaster (fruit fly)	Gdi	NP_001245953.1
Magnaporthe oryzae (rice blast fungus)	MGG_07137	XP_003715332.1
Neurospora crassa	NCU05288	XP_962059.1
Oryza sativa (rice)	Os05g0304400	NP_001055142.1
Pan troglodytes (chimpanzee)	GDI1	NP_001009061.1
Bos taurus (cattle)	GDI1	NP_776489.1
Rattus norvegicus (Norway rat)	Gdi1	NP_058784.2
Kluyveromyces lactis	KLLA0F09185g	XP_455498.1
Oryza sativa (rice)	Os05g0418000	NP_001055566.1
	GDI1	XP_001092845.2
Canis lupus familiaris (dog)	GDI1	NP_001003185.1
Arabidopsis thaliana (thale cress)	GDI2	NP_191551.1
Xenopus tropicalis (tropical clawed frog)	gdi1	XP_004919702.1
Danio rerio (zebrafish)	gdi1	NP_001018444.1
Caenorhabditis elegans (roundworm)	gdi-1	NP_001041044.1
Saccharomyces cerevisiae (baker's yeast)	GDI1	NP_011062.1
Schizosaccharomyces pombe (fission yeast)	gdi1	NP_593749.1
Arabidopsis thaliana (thale cress)	GDI1	NP_181938.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

Tumor-specific mutations in low-frequency genes affect their functional properties.
Erdem-Eraslan L, Heijsman D, de Wit M, Kremer A, Sacchetti A, van der Spek PJ, Sillevis Smitt PA, French PJ
Journal of neuro-oncology122(3)461-70(2015 May)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Human oligodendrogliomas cells stably expressing mutant GDI1 showed altered cell proliferation.
Title: Tumor-specific mutations in low-frequency genes affect their functional properties.

Data confirm isolated adrenocorticotropin deficiency (IAD) as autoimmune disease; RABGDIA (human, human recombinant, or rat) exhibits characteristics of autoantigen in anterior pituitary; patients with IAD exhibit autoantibodies against RABGDIA.
Title: Identification of the novel autoantigen candidate Rab GDP dissociation inhibitor alpha in isolated adrenocorticotropin deficiency.

The results of this study identified RabGDI as a component of the switching mechanism that is required for commissural axons to change their response from attraction to repulsion at the intermediate target
Title: RabGDI controls axonal midline crossing by regulating Robo1 surface expression.

GDI1 mutations cause an unspecific phenotype characterized by cognitive deficits of variable degree in males, and to a lesser degree in female carriers.
Title: Novel GDI1 mutation in a large family with nonsyndromic X-linked intellectual disability.

The mutations in this gene are common and do not seem to influence the gene expression so as to cause a change in phenotype.
Title: Mutations in GDI1 and X-linked non-specific mental retardation.

The following GDI1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GDI1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19497	NM_001493.3 Latest version!	Homo sapiens GDP dissociation inhibitor 1 (GDI1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu19497	NM_001493.2	Homo sapiens GDP dissociation inhibitor 1 (GDI1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GDI1 ( NM_001493.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001484.1 Homo sapiens GDP dissociation inhibitor 1 (GDI1), mRNA.

Price & Availability↑

CloneID	OHu19497
Clone ID Related Accession (Same CDS sequence)	NM_001493.3 , NM_001493.2
Accession Version	NM_001493.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	rab GDP dissociation inhibitor alpha
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA133083.1 and BC000317.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001493.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005621.1, SRR3476690.997560.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000447750.7/ ENSP00000394071.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACGAGG AATACGATGT GATCGTGCTG GGGACCGGTC TCACCGAATG CATCCTGTCG 
GGCATCATGT CTGTGAACGG GAAGAAGGTG CTGCACATGG ACCGGAACCC CTACTACGGG 
GGCGAGAGCT CCTCCATCAC ACCCCTGGAG GAGCTGTATA AGCGTTTTCA GTTGCTGGAG 
GGGCCCCCTG AGTCGATGGG CCGAGGCCGA GACTGGAATG TTGACCTGAT TCCCAAATTC 
CTCATGGCTA ACGGGCAGCT GGTAAAGATG CTACTGTATA CAGAGGTGAC TCGCTACCTG 
GACTTCAAGG TGGTGGAGGG CAGCTTTGTC TACAAGGGGG GCAAGATCTA CAAAGTGCCG 
TCCACTGAGA CTGAGGCCTT GGCTTCCAAT CTGATGGGCA TGTTTGAGAA ACGGCGCTTC 
CGCAAGTTCC TGGTGTTTGT GGCAAACTTC GATGAGAATG ACCCCAAGAC CTTTGAGGGC 
GTTGACCCCC AGACTACCAG CATGCGTGAC GTCTACCGGA AGTTTGATCT GGGCCAGGAT 
GTCATCGATT TCACTGGCCA TGCCCTGGCG CTCTACCGCA CTGATGACTA CCTGGACCAG 
CCCTGCCTTG AGACCGTCAA CCGCATCAAG TTGTACAGTG AGTCCCTGGC CCGGTATGGC 
AAGAGCCCAT ATTTATACCC GCTCTACGGC TTGGGCGAGC TGCCCCAGGG TTTTGCAAGA 
TTGAGTGCCA TCTATGGGGG GACATATATG CTGAACAAAC CTGTGGATGA CATCATCATG 
GAGAACGGCA AGGTGGTGGG CGTGAAGTCT GAGGGAGAGG TGGCCCGCTG CAAGCAGCTG 
ATCTGTGACC CCAGCTACAT CCCGGACCGT GTGCGGAAGG CTGGCCAGGT TATCCGCATC 
ATCTGTATCC TTAGCCACCC CATCAAGAAC ACCAACGACG CCAACTCCTG CCAAATAATC 
ATCCCCCAGA ACCAGGTCAA CAGGAAGTCA GACATCTACG TGTGCATGAT CTCCTATGCA 
CACAACGTGG CGGCCCAGGG CAAGTACATA GCTATTGCCA GCACTACTGT GGAGACCACG 
GACCCTGAAA AGGAGGTGGA GCCGGCTCTG GAGCTGTTGG AGCCCATTGA CCAGAAGTTT 
GTGGCTATCA GTGACTTGTA TGAGCCCATT GATGATGGTT GTGAGAGCCA GGTGTTCTGT 
TCCTGCTCCT ACGATGCCAC CACACACTTT GAGACAACCT GCAACGACAT CAAAGACATC 
TACAAACGCA TGGCTGGCAC GGCCTTTGAC TTTGAGAACA TGAAGCGCAA ACAGAACGAC 
GTCTTTGGAG AAGCTGAGCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001484.1
CDS	102..1445
Translation	MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRIICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETTDPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESQVFCSCSYDATTHFETTCNDIKDIYKRMAGTAFDFENMKRKQNDVFGEAEQ

Target ORF information:

RefSeq Version	NM_001493.3
Organism	Homo sapiens(human)
Definition	Homo sapiens GDP dissociation inhibitor 1 (GDI1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001493.3

ORF Insert Sequence:

ATGGACGAGG AATACGATGT GATCGTGCTG GGGACCGGTC TCACCGAATG CATCCTGTCG 
GGCATCATGT CTGTGAACGG GAAGAAGGTG CTGCACATGG ACCGGAACCC CTACTACGGG 
GGCGAGAGCT CCTCCATCAC ACCCCTGGAG GAGCTGTATA AGCGTTTTCA GTTGCTGGAG 
GGGCCCCCTG AGTCGATGGG CCGAGGCCGA GACTGGAATG TTGACCTGAT TCCCAAATTC 
CTCATGGCTA ACGGGCAGCT GGTAAAGATG CTACTGTATA CAGAGGTGAC TCGCTACCTG 
GACTTCAAGG TGGTGGAGGG CAGCTTTGTC TACAAGGGGG GCAAGATCTA CAAAGTGCCG 
TCCACTGAGA CTGAGGCCTT GGCTTCCAAT CTGATGGGCA TGTTTGAGAA ACGGCGCTTC 
CGCAAGTTCC TGGTGTTTGT GGCAAACTTC GATGAGAATG ACCCCAAGAC CTTTGAGGGC 
GTTGACCCCC AGACTACCAG CATGCGTGAC GTCTACCGGA AGTTTGATCT GGGCCAGGAT 
GTCATCGATT TCACTGGCCA TGCCCTGGCG CTCTACCGCA CTGATGACTA CCTGGACCAG 
CCCTGCCTTG AGACCGTCAA CCGCATCAAG TTGTACAGTG AGTCCCTGGC CCGGTATGGC 
AAGAGCCCAT ATTTATACCC GCTCTACGGC TTGGGCGAGC TGCCCCAGGG TTTTGCAAGA 
TTGAGTGCCA TCTATGGGGG GACATATATG CTGAACAAAC CTGTGGATGA CATCATCATG 
GAGAACGGCA AGGTGGTGGG CGTGAAGTCT GAGGGAGAGG TGGCCCGCTG CAAGCAGCTG 
ATCTGTGACC CCAGCTACAT CCCGGACCGT GTGCGGAAGG CTGGCCAGGT TATCCGCATC 
ATCTGTATCC TTAGCCACCC CATCAAGAAC ACCAACGACG CCAACTCCTG CCAAATAATC 
ATCCCCCAGA ACCAGGTCAA CAGGAAGTCA GACATCTACG TGTGCATGAT CTCCTATGCA 
CACAACGTGG CGGCCCAGGG CAAGTACATA GCTATTGCCA GCACTACTGT GGAGACCACG 
GACCCTGAAA AGGAGGTGGA GCCGGCTCTG GAGCTGTTGG AGCCCATTGA CCAGAAGTTT 
GTGGCTATCA GTGACTTGTA TGAGCCCATT GATGATGGTT GTGAGAGCCA GGTGTTCTGT 
TCCTGCTCCT ACGATGCCAC CACACACTTT GAGACAACCT GCAACGACAT CAAAGACATC 
TACAAACGCA TGGCTGGCAC GGCCTTTGAC TTTGAGAACA TGAAGCGCAA ACAGAACGAC 
GTCTTTGGAG AAGCTGAGCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GDI1 ( NM_001493.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001484.1 Homo sapiens GDP dissociation inhibitor 1 (GDI1), mRNA.

Price & Availability↑

CloneID	OHu19497
Clone ID Related Accession (Same CDS sequence)	NM_001493.3 , NM_001493.2
Accession Version	NM_001493.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	rab GDP dissociation inhibitor alpha
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB005169.1, DA133083.1 and BC000317.2. This sequence is a reference standard in the RefSeqGene project. On May 8, 2008 this sequence version replaced NM_001493.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005621.1, SRR1660809.241445.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGACGAGG AATACGATGT GATCGTGCTG GGGACCGGTC TCACCGAATG CATCCTGTCG 
GGCATCATGT CTGTGAACGG GAAGAAGGTG CTGCACATGG ACCGGAACCC CTACTACGGG 
GGCGAGAGCT CCTCCATCAC ACCCCTGGAG GAGCTGTATA AGCGTTTTCA GTTGCTGGAG 
GGGCCCCCTG AGTCGATGGG CCGAGGCCGA GACTGGAATG TTGACCTGAT TCCCAAATTC 
CTCATGGCTA ACGGGCAGCT GGTAAAGATG CTACTGTATA CAGAGGTGAC TCGCTACCTG 
GACTTCAAGG TGGTGGAGGG CAGCTTTGTC TACAAGGGGG GCAAGATCTA CAAAGTGCCG 
TCCACTGAGA CTGAGGCCTT GGCTTCCAAT CTGATGGGCA TGTTTGAGAA ACGGCGCTTC 
CGCAAGTTCC TGGTGTTTGT GGCAAACTTC GATGAGAATG ACCCCAAGAC CTTTGAGGGC 
GTTGACCCCC AGACTACCAG CATGCGTGAC GTCTACCGGA AGTTTGATCT GGGCCAGGAT 
GTCATCGATT TCACTGGCCA TGCCCTGGCG CTCTACCGCA CTGATGACTA CCTGGACCAG 
CCCTGCCTTG AGACCGTCAA CCGCATCAAG TTGTACAGTG AGTCCCTGGC CCGGTATGGC 
AAGAGCCCAT ATTTATACCC GCTCTACGGC TTGGGCGAGC TGCCCCAGGG TTTTGCAAGA 
TTGAGTGCCA TCTATGGGGG GACATATATG CTGAACAAAC CTGTGGATGA CATCATCATG 
GAGAACGGCA AGGTGGTGGG CGTGAAGTCT GAGGGAGAGG TGGCCCGCTG CAAGCAGCTG 
ATCTGTGACC CCAGCTACAT CCCGGACCGT GTGCGGAAGG CTGGCCAGGT TATCCGCATC 
ATCTGTATCC TTAGCCACCC CATCAAGAAC ACCAACGACG CCAACTCCTG CCAAATAATC 
ATCCCCCAGA ACCAGGTCAA CAGGAAGTCA GACATCTACG TGTGCATGAT CTCCTATGCA 
CACAACGTGG CGGCCCAGGG CAAGTACATA GCTATTGCCA GCACTACTGT GGAGACCACG 
GACCCTGAAA AGGAGGTGGA GCCGGCTCTG GAGCTGTTGG AGCCCATTGA CCAGAAGTTT 
GTGGCTATCA GTGACTTGTA TGAGCCCATT GATGATGGTT GTGAGAGCCA GGTGTTCTGT 
TCCTGCTCCT ACGATGCCAC CACACACTTT GAGACAACCT GCAACGACAT CAAAGACATC 
TACAAACGCA TGGCTGGCAC GGCCTTTGAC TTTGAGAACA TGAAGCGCAA ACAGAACGAC 
GTCTTTGGAG AAGCTGAGCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001484.1
CDS	343..1686
Translation	MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRIICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETTDPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESQVFCSCSYDATTHFETTCNDIKDIYKRMAGTAFDFENMKRKQNDVFGEAEQ

Target ORF information:

RefSeq Version	NM_001493.2
Organism	Homo sapiens(human)
Definition	Homo sapiens GDP dissociation inhibitor 1 (GDI1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001493.2

ORF Insert Sequence:

ATGGACGAGG AATACGATGT GATCGTGCTG GGGACCGGTC TCACCGAATG CATCCTGTCG 
GGCATCATGT CTGTGAACGG GAAGAAGGTG CTGCACATGG ACCGGAACCC CTACTACGGG 
GGCGAGAGCT CCTCCATCAC ACCCCTGGAG GAGCTGTATA AGCGTTTTCA GTTGCTGGAG 
GGGCCCCCTG AGTCGATGGG CCGAGGCCGA GACTGGAATG TTGACCTGAT TCCCAAATTC 
CTCATGGCTA ACGGGCAGCT GGTAAAGATG CTACTGTATA CAGAGGTGAC TCGCTACCTG 
GACTTCAAGG TGGTGGAGGG CAGCTTTGTC TACAAGGGGG GCAAGATCTA CAAAGTGCCG 
TCCACTGAGA CTGAGGCCTT GGCTTCCAAT CTGATGGGCA TGTTTGAGAA ACGGCGCTTC 
CGCAAGTTCC TGGTGTTTGT GGCAAACTTC GATGAGAATG ACCCCAAGAC CTTTGAGGGC 
GTTGACCCCC AGACTACCAG CATGCGTGAC GTCTACCGGA AGTTTGATCT GGGCCAGGAT 
GTCATCGATT TCACTGGCCA TGCCCTGGCG CTCTACCGCA CTGATGACTA CCTGGACCAG 
CCCTGCCTTG AGACCGTCAA CCGCATCAAG TTGTACAGTG AGTCCCTGGC CCGGTATGGC 
AAGAGCCCAT ATTTATACCC GCTCTACGGC TTGGGCGAGC TGCCCCAGGG TTTTGCAAGA 
TTGAGTGCCA TCTATGGGGG GACATATATG CTGAACAAAC CTGTGGATGA CATCATCATG 
GAGAACGGCA AGGTGGTGGG CGTGAAGTCT GAGGGAGAGG TGGCCCGCTG CAAGCAGCTG 
ATCTGTGACC CCAGCTACAT CCCGGACCGT GTGCGGAAGG CTGGCCAGGT TATCCGCATC 
ATCTGTATCC TTAGCCACCC CATCAAGAAC ACCAACGACG CCAACTCCTG CCAAATAATC 
ATCCCCCAGA ACCAGGTCAA CAGGAAGTCA GACATCTACG TGTGCATGAT CTCCTATGCA 
CACAACGTGG CGGCCCAGGG CAAGTACATA GCTATTGCCA GCACTACTGT GGAGACCACG 
GACCCTGAAA AGGAGGTGGA GCCGGCTCTG GAGCTGTTGG AGCCCATTGA CCAGAAGTTT 
GTGGCTATCA GTGACTTGTA TGAGCCCATT GATGATGGTT GTGAGAGCCA GGTGTTCTGT 
TCCTGCTCCT ACGATGCCAC CACACACTTT GAGACAACCT GCAACGACAT CAAAGACATC 
TACAAACGCA TGGCTGGCAC GGCCTTTGAC TTTGAGAACA TGAAGCGCAA ACAGAACGAC 
GTCTTTGGAG AAGCTGAGCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

Tumor-specific mutations in low-frequency genes affect their functional properties.
Journal of neuro-oncology122(3)461-70(2015 May)
Erdem-Eraslan L,Heijsman D,de Wit M,Kremer A,Sacchetti A,van der Spek PJ,Sillevis Smitt PA,French PJ

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

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GDI1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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