MRPL46 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPL46
Entrez Gene ID	26589
Full Name	mitochondrial ribosomal protein L46
Synonyms	C15orf4,LIECG2,P2ECSL
General protein information	Preferred Names mitochondrial ribosomal protein L46 Names 39S ribosomal protein L46, mitochondrial L46mt MRP-L46 mitochondrial large ribosomal subunit protein mL46
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q25.3
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Disorder MIM:	611851

mRNA and Protein(s)

mRNA	Protein	Name
NM_022163.4	NP_071446.2	39S ribosomal protein L46, mitochondrial
NM_022163.3	NP_071446.2	39S ribosomal protein L46, mitochondrial

Pathways from BioSystems

Homologies

Homo sapiens (human)	MRPL46	NP_071446.2
Danio rerio (zebrafish)	mrpl46	NP_001002518.1
Drosophila melanogaster (fruit fly)	mRpL46	NP_647661.1
Caenorhabditis elegans (roundworm)	mrpl-46	NP_499994.4
Canis lupus familiaris (dog)	MRPL46	XP_536185.2
Gallus gallus (chicken)	MRPL46	NP_001264041.1
Rattus norvegicus (Norway rat)	Mrpl46	NP_001013086.1
Mus musculus (house mouse)	Mrpl46	NP_075820.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006684	XP_316723.3
Xenopus tropicalis (tropical clawed frog)	mrpl46	NP_001096501.1
Pan troglodytes (chimpanzee)	MRPL46	XP_510572.2
	MRPL46	XP_001088970.1
Bos taurus (cattle)	MRPL46	NP_001029884.1

Gene Ontology
Bibliography

Related articles in PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Brown A, Rathore S, Kimanius D, Aibara S, Bai XC, Rorbach J, Amunts A, Ramakrishnan V
Nature structural & molecular biology24(10)866-869(2017 Oct)

Structure of the large ribosomal subunit from human mitochondria.
Brown A, Amunts A, Bai XC, Sugimoto Y, Edwards PC, Murshudov G, Scheres SHW, Ramakrishnan V
Science (New York, N.Y.)346(6210)718-722(2014 Nov)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Zhang Z, Gerstein M
Genomics81(5)468-80(2003 May)

Cloning, mapping and expression analysis of C15orf4, a novel human gene with homology to the yeast mitochondrial ribosomal protein Ym130 gene.
Carim-Todd L, Sumoy L, Andreu N, Estivill X, Escarceller M
DNA sequence : the journal of DNA sequencing and mapping12(2)91-6(2001)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Expression is enriched in testis. Positioned to chromosome 15q24 by radiation hybrid mapping.
Title: Cloning, mapping and expression analysis of C15orf4, a novel human gene with homology to the yeast mitochondrial ribosomal protein Ym130 gene.

The following MRPL46 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPL46 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08991	NM_022163.4 Latest version!	Homo sapiens mitochondrial ribosomal protein L46 (MRPL46), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu08991	NM_022163.3	Homo sapiens mitochondrial ribosomal protein L46 (MRPL46), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPL46 ( NM_022163.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071446.2 Homo sapiens mitochondrial ribosomal protein L46 (MRPL46), mRNA.

Price & Availability↑

CloneID	OHu08991
Clone ID Related Accession (Same CDS sequence)	NM_022163.4 , NM_022163.3
Accession Version	NM_022163.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	39S ribosomal protein L46, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC017883.1 and AF210056.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_022163.3. ##Evidence-Data-START## Transcript exon combination :: AF210056.1, SRR5189655.206709.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142670, SAMEA2144835 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000312475.5/ ENSP00000312311.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGC CCGTAAGGCG GACGCTGTTA GGGGTGGCGG GGGGTTGGCG GCGGTTCGAG 
AGGCTCTGGG CCGGCAGTCT AAGCTCTCGC AGCCTGGCTC TTGCAGCCGC ACCCTCAAGC 
AACGGATCCC CATGGCGCTT GTTGGGCGCG TTGTGCCTGC AGCGGCCACC TGTAGTCTCC 
AAGCCGTTGA CCCCATTGCA GGAAGAGATG GCGTCTCTAC TGCAGCAGAT TGAGATAGAG 
AGAAGCCTGT ATTCAGACCA CGAGCTTCGT GCTCTGGATG AAAACCAGCG ACTGGCAAAG 
AAGAAAGCTG ACCTTCATGA TGAAGAAGAT GAACAGGATA TATTGCTGGC GCAAGATTTG 
GAAGATATGT GGGAGCAGAA ATTTCTACAG TTCAAACTTG GAGCTCGCAT AACAGAAGCT 
GATGAAAAGA ATGACCGAAC ATCCCTGAAC AGGAAGCTAG ACAGGAACCT TGTCCTGTTA 
GTCAGAGAGA AGTTTGGAGA CCAGGATGTT TGGATACTGC CCCAGGCAGA GTGGCAGCCT 
GGGGAGACCC TTCGAGGAAC AGCTGAACGA ACCCTGGCCA CACTCTCAGA AAACAACATG 
GAAGCCAAGT TCCTAGGAAA TGCACCCTGT GGGCACTACA CATTCAAGTT CCCCCAGGCA 
ATGCGGACAG AGAGTAACCT CGGAGCCAAG GTGTTCTTCT TCAAAGCACT GCTATTAACT 
GGAGACTTTT CCCAGGCTGG GAATAAGGGC CATCATGTGT GGGTCACTAA GGATGAGCTG 
GGTGACTATT TGAAACCAAA ATACCTGGCC CAAGTTAGGA GGTTTGTTTC AGACCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071446.2
CDS	12..851
Translation	MAAPVRRTLLGVAGGWRRFERLWAGSLSSRSLALAAAPSSNGSPWRLLGALCLQRPPVVSKPLTPLQEEMASLLQQIEIERSLYSDHELRALDENQRLAKKKADLHDEEDEQDILLAQDLEDMWEQKFLQFKLGARITEADEKNDRTSLNRKLDRNLVLLVREKFGDQDVWILPQAEWQPGETLRGTAERTLATLSENNMEAKFLGNAPCGHYTFKFPQAMRTESNLGAKVFFFKALLLTGDFSQAGNKGHHVWVTKDELGDYLKPKYLAQVRRFVSDL

Target ORF information:

RefSeq Version	NM_022163.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L46 (MRPL46), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022163.4

ORF Insert Sequence:

ATGGCGGCGC CCGTAAGGCG GACGCTGTTA GGGGTGGCGG GGGGTTGGCG GCGGTTCGAG 
AGGCTCTGGG CCGGCAGTCT AAGCTCTCGC AGCCTGGCTC TTGCAGCCGC ACCCTCAAGC 
AACGGATCCC CATGGCGCTT GTTGGGCGCG TTGTGCCTGC AGCGGCCACC TGTAGTCTCC 
AAGCCGTTGA CCCCATTGCA GGAAGAGATG GCGTCTCTAC TGCAGCAGAT TGAGATAGAG 
AGAAGCCTGT ATTCAGACCA CGAGCTTCGT GCTCTGGATG AAAACCAGCG ACTGGCAAAG 
AAGAAAGCTG ACCTTCATGA TGAAGAAGAT GAACAGGATA TATTGCTGGC GCAAGATTTG 
GAAGATATGT GGGAGCAGAA ATTTCTACAG TTCAAACTTG GAGCTCGCAT AACAGAAGCT 
GATGAAAAGA ATGACCGAAC ATCCCTGAAC AGGAAGCTAG ACAGGAACCT TGTCCTGTTA 
GTCAGAGAGA AGTTTGGAGA CCAGGATGTT TGGATACTGC CCCAGGCAGA GTGGCAGCCT 
GGGGAGACCC TTCGAGGAAC AGCTGAACGA ACCCTGGCCA CACTCTCAGA AAACAACATG 
GAAGCCAAGT TCCTAGGAAA TGCACCCTGT GGGCACTACA CATTCAAGTT CCCCCAGGCA 
ATGCGGACAG AGAGTAACCT CGGAGCCAAG GTGTTCTTCT TCAAAGCACT GCTATTAACT 
GGAGACTTTT CCCAGGCTGG GAATAAGGGC CATCATGTGT GGGTCACTAA GGATGAGCTG 
GGTGACTATT TGAAACCAAA ATACCTGGCC CAAGTTAGGA GGTTTGTTTC AGACCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL46 ( NM_022163.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071446.2 Homo sapiens mitochondrial ribosomal protein L46 (MRPL46), mRNA.

Price & Availability↑

CloneID	OHu08991
Clone ID Related Accession (Same CDS sequence)	NM_022163.4 , NM_022163.3
Accession Version	NM_022163.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	39S ribosomal protein L46, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN309742.1, BC017883.1 and AF210056.1. This sequence is a reference standard in the RefSeqGene project. On Mar 7, 2008 this sequence version replaced NM_022163.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.164511.1, BC017883.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142670, SAMEA2144835 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGC CCGTAAGGCG GACGCTGTTA GGGGTGGCGG GGGGTTGGCG GCGGTTCGAG 
AGGCTCTGGG CCGGCAGTCT AAGCTCTCGC AGCCTGGCTC TTGCAGCCGC ACCCTCAAGC 
AACGGATCCC CATGGCGCTT GTTGGGCGCG TTGTGCCTGC AGCGGCCACC TGTAGTCTCC 
AAGCCGTTGA CCCCATTGCA GGAAGAGATG GCGTCTCTAC TGCAGCAGAT TGAGATAGAG 
AGAAGCCTGT ATTCAGACCA CGAGCTTCGT GCTCTGGATG AAAACCAGCG ACTGGCAAAG 
AAGAAAGCTG ACCTTCATGA TGAAGAAGAT GAACAGGATA TATTGCTGGC GCAAGATTTG 
GAAGATATGT GGGAGCAGAA ATTTCTACAG TTCAAACTTG GAGCTCGCAT AACAGAAGCT 
GATGAAAAGA ATGACCGAAC ATCCCTGAAC AGGAAGCTAG ACAGGAACCT TGTCCTGTTA 
GTCAGAGAGA AGTTTGGAGA CCAGGATGTT TGGATACTGC CCCAGGCAGA GTGGCAGCCT 
GGGGAGACCC TTCGAGGAAC AGCTGAACGA ACCCTGGCCA CACTCTCAGA AAACAACATG 
GAAGCCAAGT TCCTAGGAAA TGCACCCTGT GGGCACTACA CATTCAAGTT CCCCCAGGCA 
ATGCGGACAG AGAGTAACCT CGGAGCCAAG GTGTTCTTCT TCAAAGCACT GCTATTAACT 
GGAGACTTTT CCCAGGCTGG GAATAAGGGC CATCATGTGT GGGTCACTAA GGATGAGCTG 
GGTGACTATT TGAAACCAAA ATACCTGGCC CAAGTTAGGA GGTTTGTTTC AGACCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071446.2
CDS	26..865
Translation	MAAPVRRTLLGVAGGWRRFERLWAGSLSSRSLALAAAPSSNGSPWRLLGALCLQRPPVVSKPLTPLQEEMASLLQQIEIERSLYSDHELRALDENQRLAKKKADLHDEEDEQDILLAQDLEDMWEQKFLQFKLGARITEADEKNDRTSLNRKLDRNLVLLVREKFGDQDVWILPQAEWQPGETLRGTAERTLATLSENNMEAKFLGNAPCGHYTFKFPQAMRTESNLGAKVFFFKALLLTGDFSQAGNKGHHVWVTKDELGDYLKPKYLAQVRRFVSDL

Target ORF information:

RefSeq Version	NM_022163.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L46 (MRPL46), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022163.3

ORF Insert Sequence:

ATGGCGGCGC CCGTAAGGCG GACGCTGTTA GGGGTGGCGG GGGGTTGGCG GCGGTTCGAG 
AGGCTCTGGG CCGGCAGTCT AAGCTCTCGC AGCCTGGCTC TTGCAGCCGC ACCCTCAAGC 
AACGGATCCC CATGGCGCTT GTTGGGCGCG TTGTGCCTGC AGCGGCCACC TGTAGTCTCC 
AAGCCGTTGA CCCCATTGCA GGAAGAGATG GCGTCTCTAC TGCAGCAGAT TGAGATAGAG 
AGAAGCCTGT ATTCAGACCA CGAGCTTCGT GCTCTGGATG AAAACCAGCG ACTGGCAAAG 
AAGAAAGCTG ACCTTCATGA TGAAGAAGAT GAACAGGATA TATTGCTGGC GCAAGATTTG 
GAAGATATGT GGGAGCAGAA ATTTCTACAG TTCAAACTTG GAGCTCGCAT AACAGAAGCT 
GATGAAAAGA ATGACCGAAC ATCCCTGAAC AGGAAGCTAG ACAGGAACCT TGTCCTGTTA 
GTCAGAGAGA AGTTTGGAGA CCAGGATGTT TGGATACTGC CCCAGGCAGA GTGGCAGCCT 
GGGGAGACCC TTCGAGGAAC AGCTGAACGA ACCCTGGCCA CACTCTCAGA AAACAACATG 
GAAGCCAAGT TCCTAGGAAA TGCACCCTGT GGGCACTACA CATTCAAGTT CCCCCAGGCA 
ATGCGGACAG AGAGTAACCT CGGAGCCAAG GTGTTCTTCT TCAAAGCACT GCTATTAACT 
GGAGACTTTT CCCAGGCTGG GAATAAGGGC CATCATGTGT GGGTCACTAA GGATGAGCTG 
GGTGACTATT TGAAACCAAA ATACCTGGCC CAAGTTAGGA GGTTTGTTTC AGACCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Nature structural & molecular biology24(10)866-869(2017 Oct)
Brown A,Rathore S,Kimanius D,Aibara S,Bai XC,Rorbach J,Amunts A,Ramakrishnan V

Structure of the large ribosomal subunit from human mitochondria.
Science (New York, N.Y.)346(6210)718-722(2014 Nov)
Brown A,Amunts A,Bai XC,Sugimoto Y,Edwards PC,Murshudov G,Scheres SHW,Ramakrishnan V

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Genomics81(5)468-80(2003 May)
Zhang Z,Gerstein M

Cloning, mapping and expression analysis of C15orf4, a novel human gene with homology to the yeast mitochondrial ribosomal protein Ym130 gene.
DNA sequence : the journal of DNA sequencing and mapping12(2)91-6(2001)
Carim-Todd L,Sumoy L,Andreu N,Estivill X,Escarceller M

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MRPL46 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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