DUX1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DUX1
Entrez Gene ID	26584
Full Name	double homeobox 1
General protein information	Preferred Names double homeobox 1 Names double homeobox protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Summary	The human genome contains hundreds of repeats of the 3.3-kb family in regions associated with heterochromatin. The DUX gene family, including DUX1, resides within these 3.3-kb repeated elements (Beckers et al., 2001 [PubMed 11245978]). See DUX4 (MIM 606009).[supplied by OMIM, Mar 2008].
Disorder MIM:	611441

mRNA and Protein(s)

mRNA	Protein	Name
NM_012146.1	NP_036278.1	double homeobox protein 1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.
Ansseau E, Eidahl JO, Lancelot C, Tassin A, Matteotti C, Yip C, Liu J, Leroy B, Hubeau C, Gerbaux C, Cloet S, Wauters A, Zorbo S, Meyer P, Pirson I, Laoudj-Chenivesse D, Wattiez R, Harper SQ, Belayew A, Copp?e F
PloS one11(1)e0146893(2016)

Intracellular trafficking and dynamics of double homeodomain proteins.
Ostlund C, Garcia-Carrasquillo RM, Belayew A, Worman HJ
Biochemistry44(7)2378-84(2005 Feb)

Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements.
Beckers M, Gabri?ls J, van der Maarel S, De Vriese A, Frants RR, Collen D, Belayew A
Gene264(1)51-7(2001 Feb)

Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3 kb dispersed repeated elements.
Ding H, Beckers MC, Plaisance S, Marynen P, Collen D, Belayew A
Human molecular genetics7(11)1681-94(1998 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Report shows that full-length DUX1 is actively transported into the nuclei of transfected C2C12 myoblasts, and that DUX1 homeodomains contain the signals required for this localization.
Title: Intracellular trafficking and dynamics of double homeodomain proteins.

The following DUX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DUX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu31242	NM_012146.1 Latest version!	Homo sapiens double homeobox 1 (DUX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DUX1 ( NM_012146.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_036278.1 Homo sapiens double homeobox 1 (DUX1), mRNA.

Price & Availability↑

CloneID	OHu31242
Clone ID Related Accession (Same CDS sequence)	NM_012146.1
Accession Version	NM_012146.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 513bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	double homeobox protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ001481.1. ##Evidence-Data-START## Transcript is intronless :: AJ001481.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCCTCC TGACAGCTTT GGACGACACC CTCCCCGAGG AAGCCCAGGG ACCGGGAAGG 
CGAATGATAC TCCTTTCGAC CCCGAGTCAA AGTGATGCCC TGCGAGCCTG CTTTGAGCGG 
AACCTGTACC CGGGCATTGC CACCAAAGAA GAGCTGGCCC AGGGCATCGA CATTCCGGAG 
CCCAGGGTCC AGATTTGGTT TCAGAATGAG AGATCATGCC AGTTGAGGCA GCACCGGCGG 
CAATCTCGGC CCTGGCCCGG GAGACGTGAC CCGCAAAAAG GCAGACGAAA GCGGACTGCC 
ATCACCGGAT CCCAAACCGC CCTGCTCCTC CGAGCCTTTG AGAAGGATCG CTTTCCAGGC 
ATTGCTGCCA GGGAAGAGCT GGCCAGAGAG ACGGGCCTCC CGGAGTCCAG GATTCAGATC 
TGGTTTCAGA ATCGAAGAGC CAGGCACCGG GGACAGTCTG GCAGGGCGCC CACGCAGGCA 
AGCATCCGGT GCAATGCAGC CCCAATTGGG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036278.1
CDS	113..625
Translation	MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHRGQSGRAPTQASIRCNAAPIG

Target ORF information:

RefSeq Version	NM_012146.1
Organism	Homo sapiens(human)
Definition	Homo sapiens double homeobox 1 (DUX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012146.1

ORF Insert Sequence:

ATGGCCCTCC TGACAGCTTT GGACGACACC CTCCCCGAGG AAGCCCAGGG ACCGGGAAGG 
CGAATGATAC TCCTTTCGAC CCCGAGTCAA AGTGATGCCC TGCGAGCCTG CTTTGAGCGG 
AACCTGTACC CGGGCATTGC CACCAAAGAA GAGCTGGCCC AGGGCATCGA CATTCCGGAG 
CCCAGGGTCC AGATTTGGTT TCAGAATGAG AGATCATGCC AGTTGAGGCA GCACCGGCGG 
CAATCTCGGC CCTGGCCCGG GAGACGTGAC CCGCAAAAAG GCAGACGAAA GCGGACTGCC 
ATCACCGGAT CCCAAACCGC CCTGCTCCTC CGAGCCTTTG AGAAGGATCG CTTTCCAGGC 
ATTGCTGCCA GGGAAGAGCT GGCCAGAGAG ACGGGCCTCC CGGAGTCCAG GATTCAGATC 
TGGTTTCAGA ATCGAAGAGC CAGGCACCGG GGACAGTCTG GCAGGGCGCC CACGCAGGCA 
AGCATCCGGT GCAATGCAGC CCCAATTGGG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.
PloS one11(1)e0146893(2016)
Ansseau E,Eidahl JO,Lancelot C,Tassin A,Matteotti C,Yip C,Liu J,Leroy B,Hubeau C,Gerbaux C,Cloet S,Wauters A,Zorbo S,Meyer P,Pirson I,Laoudj-Chenivesse D,Wattiez R,Harper SQ,Belayew A,Copp?e F

Intracellular trafficking and dynamics of double homeodomain proteins.
Biochemistry44(7)2378-84(2005 Feb)
Ostlund C,Garcia-Carrasquillo RM,Belayew A,Worman HJ

Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements.
Gene264(1)51-7(2001 Feb)
Beckers M,Gabri?ls J,van der Maarel S,De Vriese A,Frants RR,Collen D,Belayew A

Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3 kb dispersed repeated elements.
Human molecular genetics7(11)1681-94(1998 Oct)
Ding H,Beckers MC,Plaisance S,Marynen P,Collen D,Belayew A

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DUX1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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