TIMM10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TIMM10
Entrez Gene ID	26519
Full Name	translocase of inner mitochondrial membrane 10
Synonyms	TIM10,TIM10A,TIMM10A
General protein information	Preferred Names translocase of inner mitochondrial membrane 10 Names mitochondrial import inner membrane translocase subunit Tim10 translocase of inner mitochondrial membrane 10 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.1
Summary	The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011].
Disorder MIM:	602251

mRNA and Protein(s)

mRNA	Protein	Name
NM_012456.2	NP_036588.1	mitochondrial import inner membrane translocase subunit Tim10
NM_012456.3	NP_036588.1	mitochondrial import inner membrane translocase subunit Tim10
XM_024448436.1	XP_024304204.1	mitochondrial import inner membrane translocase subunit Tim10 isoform X1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	TIMM10	XP_422986.2
Danio rerio (zebrafish)	timm10	NP_001002678.1
Drosophila melanogaster (fruit fly)	Tim10	NP_726104.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010679	XP_311395.2
Rattus norvegicus (Norway rat)	Timm10	NP_742071.1
Homo sapiens (human)	TIMM10	NP_036588.1
Pan troglodytes (chimpanzee)	TIMM10	XP_001138330.1
Mus musculus (house mouse)	Timm10	NP_038927.2
Caenorhabditis elegans (roundworm)	tin-10	NP_499480.1
Xenopus tropicalis (tropical clawed frog)	timm10	NP_989294.1
	TIMM10	XP_001102305.1
Canis lupus familiaris (dog)	TIMM10	XP_533175.1
Bos taurus (cattle)	TIMM10	NP_001039597.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
Wang AG, Yoon SY, Oh JH, Jeon YJ, Kim M, Kim JM, Byun SS, Yang JO, Kim JH, Kim DG, Yeom YI, Yoo HS, Kim YS, Kim NS
Biochemical and biophysical research communications345(3)1022-32(2006 Jul)

A germline-specific class of small RNAs binds mammalian Piwi proteins.
Girard A, Sachidanandam R, Hannon GJ, Carmell MA
Nature442(7099)199-202(2006 Jul)

Identification of novel genes expressed during rhabdomyosarcoma differentiation using cDNA microarrays.
Carey KA, Segal D, Klein R, Sanigorski A, Walder K, Collier GR, Cameron-Smith D
Pathology international56(5)246-55(2006 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Marked differences in the expression of PTMA and Tim10 were observed during the differentiation of human primary skeletal muscle cells.
Title: Identification of novel genes expressed during rhabdomyosarcoma differentiation using cDNA microarrays.

The crystal structure of TIM9.10 described here reveals a previously undescribed alpha-propeller topology in which helical "blades" radiate from a narrow central pore lined with polar residues.
Title: Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller.

in contrast to yeast, only a small fraction of Tim9-Tim10a-Tim10b complex is in a stable association with Tim22
Title: Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria.

The following TIMM10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TIMM10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17406	NM_012456.3 Latest version!	Homo sapiens translocase of inner mitochondrial membrane 10 (TIMM10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17406	XM_024448436.1 Latest version!	Homo sapiens translocase of inner mitochondrial membrane 10 (TIMM10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17406	NM_012456.2	Homo sapiens translocase of inner mitochondrial membrane 10 (TIMM10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TIMM10 ( NM_012456.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036588.1 Homo sapiens translocase of inner mitochondrial membrane 10 (TIMM10), mRNA.

Price & Availability↑

CloneID	OHu17406
Clone ID Related Accession (Same CDS sequence)	NM_012456.2 , NM_012456.3 , XM_024448436.1
Accession Version	NM_012456.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 273bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	mitochondrial import inner membrane translocase subunit Tim10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB106298.1, AF150089.1 and AI498204.1. On Apr 20, 2006 this sequence version replaced NM_012456.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB992401.1, SRR1163657.377216.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149178, SAMEA2150385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGATCCTC TCAGGGCCCA ACAGCTGGCT GCGGAGCTGG AGGTGGAGAT GATGGCCGAT 
ATGTACAACA GAATGACCAG TGCCTGCCAC CGGAAGTGTG TGCCTCCTCA CTACAAGGAA 
GCAGAGCTCT CCAAGGGCGA GTCTGTGTGC CTGGACCGAT GTGTCTCTAA GTACCTGGAC 
ATCCATGAGC GGATGGGCAA AAAGTTGACA GAGTTGTCTA TGCAGGATGA AGAGCTGATG 
AAGAGGGTGC AGCAGAGCTC TGGGCCTGCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036588.1
CDS	148..420
Translation	MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELSKGESVCLDRCVSKYLDIHERMGKKLTELSMQDEELMKRVQQSSGPA

Target ORF information:

RefSeq Version	NM_012456.2
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of inner mitochondrial membrane 10 (TIMM10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012456.2

ORF Insert Sequence:

ATGGATCCTC TCAGGGCCCA ACAGCTGGCT GCGGAGCTGG AGGTGGAGAT GATGGCCGAT 
ATGTACAACA GAATGACCAG TGCCTGCCAC CGGAAGTGTG TGCCTCCTCA CTACAAGGAA 
GCAGAGCTCT CCAAGGGCGA GTCTGTGTGC CTGGACCGAT GTGTCTCTAA GTACCTGGAC 
ATCCATGAGC GGATGGGCAA AAAGTTGACA GAGTTGTCTA TGCAGGATGA AGAGCTGATG 
AAGAGGGTGC AGCAGAGCTC TGGGCCTGCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TIMM10 ( NM_012456.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036588.1 Homo sapiens translocase of inner mitochondrial membrane 10 (TIMM10), mRNA.

Price & Availability↑

CloneID	OHu17406
Clone ID Related Accession (Same CDS sequence)	NM_012456.2 , NM_012456.3 , XM_024448436.1
Accession Version	NM_012456.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 273bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	mitochondrial import inner membrane translocase subunit Tim10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB106298.1, AF150089.1 and AI498204.1. On Nov 22, 2018 this sequence version replaced NM_012456.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.430185.1, SRR5189658.168541.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149178, SAMEA2150385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000257245.9/ ENSP00000257245.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATCCTC TCAGGGCCCA ACAGCTGGCT GCGGAGCTGG AGGTGGAGAT GATGGCCGAT 
ATGTACAACA GAATGACCAG TGCCTGCCAC CGGAAGTGTG TGCCTCCTCA CTACAAGGAA 
GCAGAGCTCT CCAAGGGCGA GTCTGTGTGC CTGGACCGAT GTGTCTCTAA GTACCTGGAC 
ATCCATGAGC GGATGGGCAA AAAGTTGACA GAGTTGTCTA TGCAGGATGA AGAGCTGATG 
AAGAGGGTGC AGCAGAGCTC TGGGCCTGCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036588.1
CDS	143..415
Translation	MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELSKGESVCLDRCVSKYLDIHERMGKKLTELSMQDEELMKRVQQSSGPA

Target ORF information:

RefSeq Version	NM_012456.3
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of inner mitochondrial membrane 10 (TIMM10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012456.3

ORF Insert Sequence:

ATGGATCCTC TCAGGGCCCA ACAGCTGGCT GCGGAGCTGG AGGTGGAGAT GATGGCCGAT 
ATGTACAACA GAATGACCAG TGCCTGCCAC CGGAAGTGTG TGCCTCCTCA CTACAAGGAA 
GCAGAGCTCT CCAAGGGCGA GTCTGTGTGC CTGGACCGAT GTGTCTCTAA GTACCTGGAC 
ATCCATGAGC GGATGGGCAA AAAGTTGACA GAGTTGTCTA TGCAGGATGA AGAGCTGATG 
AAGAGGGTGC AGCAGAGCTC TGGGCCTGCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TIMM10 ( XM_024448436.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024304204.1 Homo sapiens translocase of inner mitochondrial membrane 10 (TIMM10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu17406
Clone ID Related Accession (Same CDS sequence)	NM_012456.2 , NM_012456.3 , XM_024448436.1
Accession Version	XM_024448436.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 273bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	mitochondrial import inner membrane translocase subunit Tim10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATCCTC TCAGGGCCCA ACAGCTGGCT GCGGAGCTGG AGGTGGAGAT GATGGCCGAT 
ATGTACAACA GAATGACCAG TGCCTGCCAC CGGAAGTGTG TGCCTCCTCA CTACAAGGAA 
GCAGAGCTCT CCAAGGGCGA GTCTGTGTGC CTGGACCGAT GTGTCTCTAA GTACCTGGAC 
ATCCATGAGC GGATGGGCAA AAAGTTGACA GAGTTGTCTA TGCAGGATGA AGAGCTGATG 
AAGAGGGTGC AGCAGAGCTC TGGGCCTGCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024304204.1
CDS	1121..1393
Translation	MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELSKGESVCLDRCVSKYLDIHERMGKKLTELSMQDEELMKRVQQSSGPA

Target ORF information:

RefSeq Version	XM_024448436.1
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of inner mitochondrial membrane 10 (TIMM10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024448436.1

ORF Insert Sequence:

ATGGATCCTC TCAGGGCCCA ACAGCTGGCT GCGGAGCTGG AGGTGGAGAT GATGGCCGAT 
ATGTACAACA GAATGACCAG TGCCTGCCAC CGGAAGTGTG TGCCTCCTCA CTACAAGGAA 
GCAGAGCTCT CCAAGGGCGA GTCTGTGTGC CTGGACCGAT GTGTCTCTAA GTACCTGGAC 
ATCCATGAGC GGATGGGCAA AAAGTTGACA GAGTTGTCTA TGCAGGATGA AGAGCTGATG 
AAGAGGGTGC AGCAGAGCTC TGGGCCTGCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
Biochemical and biophysical research communications345(3)1022-32(2006 Jul)
Wang AG,Yoon SY,Oh JH,Jeon YJ,Kim M,Kim JM,Byun SS,Yang JO,Kim JH,Kim DG,Yeom YI,Yoo HS,Kim YS,Kim NS

A germline-specific class of small RNAs binds mammalian Piwi proteins.
Nature442(7099)199-202(2006 Jul)
Girard A,Sachidanandam R,Hannon GJ,Carmell MA

Identification of novel genes expressed during rhabdomyosarcoma differentiation using cDNA microarrays.
Pathology international56(5)246-55(2006 May)
Carey KA,Segal D,Klein R,Sanigorski A,Walder K,Collier GR,Cameron-Smith D

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TIMM10 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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