FBXO5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FBXO5
Entrez Gene ID	26271
Full Name	F-box protein 5
Synonyms	EMI1,FBX5,Fbxo31
General protein information	Preferred Names F-box protein 5 Names F-box only protein 5 F-box protein Fbx5 early mitotic inhibitor 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q25.2
Summary	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008].
Disorder MIM:	606013

mRNA and Protein(s)

mRNA	Protein	Name
NM_012177.4	NP_036309.1	F-box only protein 5 isoform a
NM_001142522.2	NP_001135994.1	F-box only protein 5 isoform b
NM_001142522.3	NP_001135994.1	F-box only protein 5 isoform b
NM_012177.5	NP_036309.1	F-box only protein 5 isoform a

Pathways from BioSystems

Homologies

Homo sapiens (human)	FBXO5	NP_036309.1
	FBXO5	XP_001096104.1
Gallus gallus (chicken)	FBXO5	XP_419681.3
Canis lupus familiaris (dog)	FBXO5	XP_854840.2
Mus musculus (house mouse)	Fbxo5	NP_080271.2
Pan troglodytes (chimpanzee)	FBXO5	XP_518817.2
Rattus norvegicus (Norway rat)	Fbxo5	NP_001099676.1
Danio rerio (zebrafish)	fbxo5	NP_001003869.1
Xenopus tropicalis (tropical clawed frog)	fbxo5	NP_001037934.1

Gene Ontology
Bibliography

Related articles in PubMed

In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis.
Vaidyanathan S, Cato K, Tang L, Pavey S, Haass NK, Gabrielli BG, Duijf PH
Oncogene35(41)5446-5455(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The fact that Emi1 overexpression promotes chromosome instability (CIN) and the formation of solid cancers in vivo indicates that Emi1 overexpression actively drives solid tumorigenesis. These novel mechanistic insights have important clinical implications.
Title: In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis.

Examined eoffect of Emi1 over-expression on Skp2 expression in breast cancer. Found expression of Emi1 was positively related with Skp2 expression; Emi1 expression correlated significantly with histologic grade. Skp2 expression obtained similar results.
Title: The expression and prognosis of Emi1 and Skp2 in breast carcinoma: associated with PI3K/Akt pathway and cell proliferation.

Human papillomavirus type 16 E7 expression causes increased EMI1 mRNA expression and also inhibits EMI1 degradation.
Title: Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis.

The C-terminal domain inhibits multiple APC/C(CDH1) functions. The intrinsically disordered D-box, linker & tail elements, & a structured Zn-binding domain synergistically block the substrate-binding site & inhibit ubiquitin-chain elongation.
Title: Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.

Emi1 depletion enhances the sensitivity of cancer cells to doxorubicin and x-ray irradiation.
Title: Selective enhancing effect of early mitotic inhibitor 1 (Emi1) depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cells.

The following FBXO5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FBXO5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31493	NM_012177.5 Latest version!	Homo sapiens F-box protein 5 (FBXO5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu32114	NM_001142522.3 Latest version!	Homo sapiens F-box protein 5 (FBXO5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu32114	NM_001142522.2	Homo sapiens F-box protein 5 (FBXO5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu31493	NM_012177.4	Homo sapiens F-box protein 5 (FBXO5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FBXO5 ( NM_012177.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036309.1 Homo sapiens F-box protein 5 (FBXO5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31493
Clone ID Related Accession (Same CDS sequence)	NM_012177.4 , NM_012177.5
Accession Version	NM_012177.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-09
Organism	Homo sapiens(human)
Product	F-box only protein 5 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA819893.1, BC018905.1, AJ420499.1, AF129535.2 and AI769650.1. On Nov 22, 2016 this sequence version replaced NM_012177.3. Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.149738.1, SRR1660807.51719.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267754, SAMN03267767 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCCGGC GCCCCTGCAG CTGCGCCCTA CGGCCACCCC GCTGCTCCTG CAGCGCCAGC 
CCCAGCGCAG TGACAGCCGC CGGGCGCCCT CGACCCTCGG ATAGTTGTAA AGAAGAAAGT 
TCTACCCTTT CTGTCAAAAT GAAGTGTGAT TTTAATTGTA ACCATGTTCA TTCCGGACTT 
AAACTGGTAA AACCTGATGA CATTGGAAGA CTAGTTTCCT ACACCCCTGC ATATTTGGAA 
GGTTCCTGTA AAGACTGCAT TAAAGACTAT GAAAGGCTGT CATGTATTGG GTCACCGATT 
GTGAGCCCTA GGATTGTACA ACTTGAAACT GAAAGCAAGC GCTTGCATAA CAAGGAAAAT 
CAACATGTGC AACAGACACT TAATAGTACA AATGAAATAG AAGCACTAGA GACCAGTAGA 
CTTTATGAAG ACAGTGGCTA TTCCTCATTT TCTCTACAAA GTGGCCTCAG TGAACATGAA 
GAAGGTAGCC TCCTGGAGGA GAATTTCGGT GACAGTCTAC AATCCTGCCT GCTACAAATA 
CAAAGCCCAG ACCAATATCC CAACAAAAAC TTGCTGCCAG TTCTTCATTT TGAAAAAGTG 
GTTTGTTCAA CATTAAAAAA GAATGCAAAA CGAAATCCTA AAGTAGATCG GGAGATGCTG 
AAGGAAATTA TAGCCAGAGG AAATTTTAGA CTGCAGAATA TAATTGGCAG AAAAATGGGC 
CTAGAATGTG TAGATATTCT CAGCGAACTC TTTCGAAGGG GACTCAGACA TGTCTTAGCA 
ACTATTTTAG CACAACTCAG TGACATGGAC TTAATCAATG TGTCTAAAGT GAGCACAACT 
TGGAAGAAGA TCCTAGAAGA TGATAAGGGG GCATTCCAGT TGTACAGTAA AGCAATACAA 
AGAGTTACCG AAAACAACAA TAAATTTTCA CCTCATGCTT CAACCAGAGA ATATGTTATG 
TTCAGAACCC CACTGGCTTC TGTTCAGAAA TCAGCAGCCC AGACTTCTCT CAAAAAAGAT 
GCTCAAACCA AGTTATCCAA TCAAGGTGAT CAGAAAGGTT CTACTTATAG TCGACACAAT 
GAATTCTCTG AGGTTGCCAA GACATTGAAA AAGAACGAAA GCCTCAAAGC CTGTATTCGC 
TGTAATTCAC CTGCAAAATA TGATTGCTAT TTACAACGGG CAACCTGCAA ACGAGAAGGC 
TGTGGATTTG ATTATTGTAC GAAGTGTCTC TGTAATTATC ATACTACTAA AGACTGTTCA 
GATGGCAAGC TCCTCAAAGC CAGTTGTAAA ATAGGTCCCC TGCCTGGTAC AAAGAAAAGC 
AAAAAGAATT TACGAAGATT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036309.1
CDS	124..1467
Translation	MSRRPCSCALRPPRCSCSASPSAVTAAGRPRPSDSCKEESSTLSVKMKCDFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVQLETESKRLHNKENQHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENFGDSLQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNFRLQNIIGRKMGLECVDILSELFRRGLRHVLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQRVTENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL

Target ORF information:

RefSeq Version	NM_012177.4
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 5 (FBXO5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012177.4

ORF Insert Sequence:

ATGAGCCGGC GCCCCTGCAG CTGCGCCCTA CGGCCACCCC GCTGCTCCTG CAGCGCCAGC 
CCCAGCGCAG TGACAGCCGC CGGGCGCCCT CGACCCTCGG ATAGTTGTAA AGAAGAAAGT 
TCTACCCTTT CTGTCAAAAT GAAGTGTGAT TTTAATTGTA ACCATGTTCA TTCCGGACTT 
AAACTGGTAA AACCTGATGA CATTGGAAGA CTAGTTTCCT ACACCCCTGC ATATTTGGAA 
GGTTCCTGTA AAGACTGCAT TAAAGACTAT GAAAGGCTGT CATGTATTGG GTCACCGATT 
GTGAGCCCTA GGATTGTACA ACTTGAAACT GAAAGCAAGC GCTTGCATAA CAAGGAAAAT 
CAACATGTGC AACAGACACT TAATAGTACA AATGAAATAG AAGCACTAGA GACCAGTAGA 
CTTTATGAAG ACAGTGGCTA TTCCTCATTT TCTCTACAAA GTGGCCTCAG TGAACATGAA 
GAAGGTAGCC TCCTGGAGGA GAATTTCGGT GACAGTCTAC AATCCTGCCT GCTACAAATA 
CAAAGCCCAG ACCAATATCC CAACAAAAAC TTGCTGCCAG TTCTTCATTT TGAAAAAGTG 
GTTTGTTCAA CATTAAAAAA GAATGCAAAA CGAAATCCTA AAGTAGATCG GGAGATGCTG 
AAGGAAATTA TAGCCAGAGG AAATTTTAGA CTGCAGAATA TAATTGGCAG AAAAATGGGC 
CTAGAATGTG TAGATATTCT CAGCGAACTC TTTCGAAGGG GACTCAGACA TGTCTTAGCA 
ACTATTTTAG CACAACTCAG TGACATGGAC TTAATCAATG TGTCTAAAGT GAGCACAACT 
TGGAAGAAGA TCCTAGAAGA TGATAAGGGG GCATTCCAGT TGTACAGTAA AGCAATACAA 
AGAGTTACCG AAAACAACAA TAAATTTTCA CCTCATGCTT CAACCAGAGA ATATGTTATG 
TTCAGAACCC CACTGGCTTC TGTTCAGAAA TCAGCAGCCC AGACTTCTCT CAAAAAAGAT 
GCTCAAACCA AGTTATCCAA TCAAGGTGAT CAGAAAGGTT CTACTTATAG TCGACACAAT 
GAATTCTCTG AGGTTGCCAA GACATTGAAA AAGAACGAAA GCCTCAAAGC CTGTATTCGC 
TGTAATTCAC CTGCAAAATA TGATTGCTAT TTACAACGGG CAACCTGCAA ACGAGAAGGC 
TGTGGATTTG ATTATTGTAC GAAGTGTCTC TGTAATTATC ATACTACTAA AGACTGTTCA 
GATGGCAAGC TCCTCAAAGC CAGTTGTAAA ATAGGTCCCC TGCCTGGTAC AAAGAAAAGC 
AAAAAGAATT TACGAAGATT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXO5 ( NM_012177.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_036309.1 Homo sapiens F-box protein 5 (FBXO5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31493
Clone ID Related Accession (Same CDS sequence)	NM_012177.4 , NM_012177.5
Accession Version	NM_012177.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	F-box only protein 5 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA819893.1, BC018905.1, AJ420499.1 and AF129535.2. On Nov 23, 2018 this sequence version replaced NM_012177.4. Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189661.181552.1, SRR1660803.149738.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267754, SAMN03267767 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000229758.8/ ENSP00000229758.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCCGGC GCCCCTGCAG CTGCGCCCTA CGGCCACCCC GCTGCTCCTG CAGCGCCAGC 
CCCAGCGCAG TGACAGCCGC CGGGCGCCCT CGACCCTCGG ATAGTTGTAA AGAAGAAAGT 
TCTACCCTTT CTGTCAAAAT GAAGTGTGAT TTTAATTGTA ACCATGTTCA TTCCGGACTT 
AAACTGGTAA AACCTGATGA CATTGGAAGA CTAGTTTCCT ACACCCCTGC ATATTTGGAA 
GGTTCCTGTA AAGACTGCAT TAAAGACTAT GAAAGGCTGT CATGTATTGG GTCACCGATT 
GTGAGCCCTA GGATTGTACA ACTTGAAACT GAAAGCAAGC GCTTGCATAA CAAGGAAAAT 
CAACATGTGC AACAGACACT TAATAGTACA AATGAAATAG AAGCACTAGA GACCAGTAGA 
CTTTATGAAG ACAGTGGCTA TTCCTCATTT TCTCTACAAA GTGGCCTCAG TGAACATGAA 
GAAGGTAGCC TCCTGGAGGA GAATTTCGGT GACAGTCTAC AATCCTGCCT GCTACAAATA 
CAAAGCCCAG ACCAATATCC CAACAAAAAC TTGCTGCCAG TTCTTCATTT TGAAAAAGTG 
GTTTGTTCAA CATTAAAAAA GAATGCAAAA CGAAATCCTA AAGTAGATCG GGAGATGCTG 
AAGGAAATTA TAGCCAGAGG AAATTTTAGA CTGCAGAATA TAATTGGCAG AAAAATGGGC 
CTAGAATGTG TAGATATTCT CAGCGAACTC TTTCGAAGGG GACTCAGACA TGTCTTAGCA 
ACTATTTTAG CACAACTCAG TGACATGGAC TTAATCAATG TGTCTAAAGT GAGCACAACT 
TGGAAGAAGA TCCTAGAAGA TGATAAGGGG GCATTCCAGT TGTACAGTAA AGCAATACAA 
AGAGTTACCG AAAACAACAA TAAATTTTCA CCTCATGCTT CAACCAGAGA ATATGTTATG 
TTCAGAACCC CACTGGCTTC TGTTCAGAAA TCAGCAGCCC AGACTTCTCT CAAAAAAGAT 
GCTCAAACCA AGTTATCCAA TCAAGGTGAT CAGAAAGGTT CTACTTATAG TCGACACAAT 
GAATTCTCTG AGGTTGCCAA GACATTGAAA AAGAACGAAA GCCTCAAAGC CTGTATTCGC 
TGTAATTCAC CTGCAAAATA TGATTGCTAT TTACAACGGG CAACCTGCAA ACGAGAAGGC 
TGTGGATTTG ATTATTGTAC GAAGTGTCTC TGTAATTATC ATACTACTAA AGACTGTTCA 
GATGGCAAGC TCCTCAAAGC CAGTTGTAAA ATAGGTCCCC TGCCTGGTAC AAAGAAAAGC 
AAAAAGAATT TACGAAGATT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036309.1
CDS	83..1426
Translation	MSRRPCSCALRPPRCSCSASPSAVTAAGRPRPSDSCKEESSTLSVKMKCDFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVQLETESKRLHNKENQHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENFGDSLQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNFRLQNIIGRKMGLECVDILSELFRRGLRHVLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQRVTENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL

Target ORF information:

RefSeq Version	NM_012177.5
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 5 (FBXO5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012177.5

ORF Insert Sequence:

ATGAGCCGGC GCCCCTGCAG CTGCGCCCTA CGGCCACCCC GCTGCTCCTG CAGCGCCAGC 
CCCAGCGCAG TGACAGCCGC CGGGCGCCCT CGACCCTCGG ATAGTTGTAA AGAAGAAAGT 
TCTACCCTTT CTGTCAAAAT GAAGTGTGAT TTTAATTGTA ACCATGTTCA TTCCGGACTT 
AAACTGGTAA AACCTGATGA CATTGGAAGA CTAGTTTCCT ACACCCCTGC ATATTTGGAA 
GGTTCCTGTA AAGACTGCAT TAAAGACTAT GAAAGGCTGT CATGTATTGG GTCACCGATT 
GTGAGCCCTA GGATTGTACA ACTTGAAACT GAAAGCAAGC GCTTGCATAA CAAGGAAAAT 
CAACATGTGC AACAGACACT TAATAGTACA AATGAAATAG AAGCACTAGA GACCAGTAGA 
CTTTATGAAG ACAGTGGCTA TTCCTCATTT TCTCTACAAA GTGGCCTCAG TGAACATGAA 
GAAGGTAGCC TCCTGGAGGA GAATTTCGGT GACAGTCTAC AATCCTGCCT GCTACAAATA 
CAAAGCCCAG ACCAATATCC CAACAAAAAC TTGCTGCCAG TTCTTCATTT TGAAAAAGTG 
GTTTGTTCAA CATTAAAAAA GAATGCAAAA CGAAATCCTA AAGTAGATCG GGAGATGCTG 
AAGGAAATTA TAGCCAGAGG AAATTTTAGA CTGCAGAATA TAATTGGCAG AAAAATGGGC 
CTAGAATGTG TAGATATTCT CAGCGAACTC TTTCGAAGGG GACTCAGACA TGTCTTAGCA 
ACTATTTTAG CACAACTCAG TGACATGGAC TTAATCAATG TGTCTAAAGT GAGCACAACT 
TGGAAGAAGA TCCTAGAAGA TGATAAGGGG GCATTCCAGT TGTACAGTAA AGCAATACAA 
AGAGTTACCG AAAACAACAA TAAATTTTCA CCTCATGCTT CAACCAGAGA ATATGTTATG 
TTCAGAACCC CACTGGCTTC TGTTCAGAAA TCAGCAGCCC AGACTTCTCT CAAAAAAGAT 
GCTCAAACCA AGTTATCCAA TCAAGGTGAT CAGAAAGGTT CTACTTATAG TCGACACAAT 
GAATTCTCTG AGGTTGCCAA GACATTGAAA AAGAACGAAA GCCTCAAAGC CTGTATTCGC 
TGTAATTCAC CTGCAAAATA TGATTGCTAT TTACAACGGG CAACCTGCAA ACGAGAAGGC 
TGTGGATTTG ATTATTGTAC GAAGTGTCTC TGTAATTATC ATACTACTAA AGACTGTTCA 
GATGGCAAGC TCCTCAAAGC CAGTTGTAAA ATAGGTCCCC TGCCTGGTAC AAAGAAAAGC 
AAAAAGAATT TACGAAGATT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXO5 ( NM_001142522.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001135994.1 Homo sapiens F-box protein 5 (FBXO5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu32114
Clone ID Related Accession (Same CDS sequence)	NM_001142522.2 , NM_001142522.3
Accession Version	NM_001142522.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1206bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-17
Organism	Homo sapiens(human)
Product	F-box only protein 5 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA751659.1, BI838832.1, BC018905.1, AJ420499.1, AF129535.2 and AI769650.1. On Nov 22, 2016 this sequence version replaced NM_001142522.1. Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform b has a shorter N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK055221.1, SRR1660805.68484.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267767, SAMN03267770 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGTGTG ATTTTAATTG TAACCATGTT CATTCCGGAC TTAAACTGGT AAAACCTGAT 
GACATTGGAA GACTAGTTTC CTACACCCCT GCATATTTGG AAGGTTCCTG TAAAGACTGC 
ATTAAAGACT ATGAAAGGCT GTCATGTATT GGGTCACCGA TTGTGAGCCC TAGGATTGTA 
CAACTTGAAA CTGAAAGCAA GCGCTTGCAT AACAAGGAAA ATCAACATGT GCAACAGACA 
CTTAATAGTA CAAATGAAAT AGAAGCACTA GAGACCAGTA GACTTTATGA AGACAGTGGC 
TATTCCTCAT TTTCTCTACA AAGTGGCCTC AGTGAACATG AAGAAGGTAG CCTCCTGGAG 
GAGAATTTCG GTGACAGTCT ACAATCCTGC CTGCTACAAA TACAAAGCCC AGACCAATAT 
CCCAACAAAA ACTTGCTGCC AGTTCTTCAT TTTGAAAAAG TGGTTTGTTC AACATTAAAA 
AAGAATGCAA AACGAAATCC TAAAGTAGAT CGGGAGATGC TGAAGGAAAT TATAGCCAGA 
GGAAATTTTA GACTGCAGAA TATAATTGGC AGAAAAATGG GCCTAGAATG TGTAGATATT 
CTCAGCGAAC TCTTTCGAAG GGGACTCAGA CATGTCTTAG CAACTATTTT AGCACAACTC 
AGTGACATGG ACTTAATCAA TGTGTCTAAA GTGAGCACAA CTTGGAAGAA GATCCTAGAA 
GATGATAAGG GGGCATTCCA GTTGTACAGT AAAGCAATAC AAAGAGTTAC CGAAAACAAC 
AATAAATTTT CACCTCATGC TTCAACCAGA GAATATGTTA TGTTCAGAAC CCCACTGGCT 
TCTGTTCAGA AATCAGCAGC CCAGACTTCT CTCAAAAAAG ATGCTCAAAC CAAGTTATCC 
AATCAAGGTG ATCAGAAAGG TTCTACTTAT AGTCGACACA ATGAATTCTC TGAGGTTGCC 
AAGACATTGA AAAAGAACGA AAGCCTCAAA GCCTGTATTC GCTGTAATTC ACCTGCAAAA 
TATGATTGCT ATTTACAACG GGCAACCTGC AAACGAGAAG GCTGTGGATT TGATTATTGT 
ACGAAGTGTC TCTGTAATTA TCATACTACT AAAGACTGTT CAGATGGCAA GCTCCTCAAA 
GCCAGTTGTA AAATAGGTCC CCTGCCTGGT ACAAAGAAAA GCAAAAAGAA TTTACGAAGA 
TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135994.1
CDS	422..1627
Translation	MKCDFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVQLETESKRLHNKENQHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENFGDSLQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNFRLQNIIGRKMGLECVDILSELFRRGLRHVLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQRVTENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL

Target ORF information:

RefSeq Version	NM_001142522.2
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 5 (FBXO5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142522.2

ORF Insert Sequence:

ATGAAGTGTG ATTTTAATTG TAACCATGTT CATTCCGGAC TTAAACTGGT AAAACCTGAT 
GACATTGGAA GACTAGTTTC CTACACCCCT GCATATTTGG AAGGTTCCTG TAAAGACTGC 
ATTAAAGACT ATGAAAGGCT GTCATGTATT GGGTCACCGA TTGTGAGCCC TAGGATTGTA 
CAACTTGAAA CTGAAAGCAA GCGCTTGCAT AACAAGGAAA ATCAACATGT GCAACAGACA 
CTTAATAGTA CAAATGAAAT AGAAGCACTA GAGACCAGTA GACTTTATGA AGACAGTGGC 
TATTCCTCAT TTTCTCTACA AAGTGGCCTC AGTGAACATG AAGAAGGTAG CCTCCTGGAG 
GAGAATTTCG GTGACAGTCT ACAATCCTGC CTGCTACAAA TACAAAGCCC AGACCAATAT 
CCCAACAAAA ACTTGCTGCC AGTTCTTCAT TTTGAAAAAG TGGTTTGTTC AACATTAAAA 
AAGAATGCAA AACGAAATCC TAAAGTAGAT CGGGAGATGC TGAAGGAAAT TATAGCCAGA 
GGAAATTTTA GACTGCAGAA TATAATTGGC AGAAAAATGG GCCTAGAATG TGTAGATATT 
CTCAGCGAAC TCTTTCGAAG GGGACTCAGA CATGTCTTAG CAACTATTTT AGCACAACTC 
AGTGACATGG ACTTAATCAA TGTGTCTAAA GTGAGCACAA CTTGGAAGAA GATCCTAGAA 
GATGATAAGG GGGCATTCCA GTTGTACAGT AAAGCAATAC AAAGAGTTAC CGAAAACAAC 
AATAAATTTT CACCTCATGC TTCAACCAGA GAATATGTTA TGTTCAGAAC CCCACTGGCT 
TCTGTTCAGA AATCAGCAGC CCAGACTTCT CTCAAAAAAG ATGCTCAAAC CAAGTTATCC 
AATCAAGGTG ATCAGAAAGG TTCTACTTAT AGTCGACACA ATGAATTCTC TGAGGTTGCC 
AAGACATTGA AAAAGAACGA AAGCCTCAAA GCCTGTATTC GCTGTAATTC ACCTGCAAAA 
TATGATTGCT ATTTACAACG GGCAACCTGC AAACGAGAAG GCTGTGGATT TGATTATTGT 
ACGAAGTGTC TCTGTAATTA TCATACTACT AAAGACTGTT CAGATGGCAA GCTCCTCAAA 
GCCAGTTGTA AAATAGGTCC CCTGCCTGGT ACAAAGAAAA GCAAAAAGAA TTTACGAAGA 
TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXO5 ( NM_001142522.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001135994.1 Homo sapiens F-box protein 5 (FBXO5), transcript variant 2, mRNA.

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CloneID	OHu32114
Clone ID Related Accession (Same CDS sequence)	NM_001142522.2 , NM_001142522.3
Accession Version	NM_001142522.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1206bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-30
Organism	Homo sapiens(human)
Product	F-box only protein 5 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI838832.1, BC018905.1, AJ420499.1 and AF129535.2. On May 31, 2019 this sequence version replaced NM_001142522.2. Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform b has a shorter N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK055221.1, AJ420499.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267767, SAMN03267770 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGTGTG ATTTTAATTG TAACCATGTT CATTCCGGAC TTAAACTGGT AAAACCTGAT 
GACATTGGAA GACTAGTTTC CTACACCCCT GCATATTTGG AAGGTTCCTG TAAAGACTGC 
ATTAAAGACT ATGAAAGGCT GTCATGTATT GGGTCACCGA TTGTGAGCCC TAGGATTGTA 
CAACTTGAAA CTGAAAGCAA GCGCTTGCAT AACAAGGAAA ATCAACATGT GCAACAGACA 
CTTAATAGTA CAAATGAAAT AGAAGCACTA GAGACCAGTA GACTTTATGA AGACAGTGGC 
TATTCCTCAT TTTCTCTACA AAGTGGCCTC AGTGAACATG AAGAAGGTAG CCTCCTGGAG 
GAGAATTTCG GTGACAGTCT ACAATCCTGC CTGCTACAAA TACAAAGCCC AGACCAATAT 
CCCAACAAAA ACTTGCTGCC AGTTCTTCAT TTTGAAAAAG TGGTTTGTTC AACATTAAAA 
AAGAATGCAA AACGAAATCC TAAAGTAGAT CGGGAGATGC TGAAGGAAAT TATAGCCAGA 
GGAAATTTTA GACTGCAGAA TATAATTGGC AGAAAAATGG GCCTAGAATG TGTAGATATT 
CTCAGCGAAC TCTTTCGAAG GGGACTCAGA CATGTCTTAG CAACTATTTT AGCACAACTC 
AGTGACATGG ACTTAATCAA TGTGTCTAAA GTGAGCACAA CTTGGAAGAA GATCCTAGAA 
GATGATAAGG GGGCATTCCA GTTGTACAGT AAAGCAATAC AAAGAGTTAC CGAAAACAAC 
AATAAATTTT CACCTCATGC TTCAACCAGA GAATATGTTA TGTTCAGAAC CCCACTGGCT 
TCTGTTCAGA AATCAGCAGC CCAGACTTCT CTCAAAAAAG ATGCTCAAAC CAAGTTATCC 
AATCAAGGTG ATCAGAAAGG TTCTACTTAT AGTCGACACA ATGAATTCTC TGAGGTTGCC 
AAGACATTGA AAAAGAACGA AAGCCTCAAA GCCTGTATTC GCTGTAATTC ACCTGCAAAA 
TATGATTGCT ATTTACAACG GGCAACCTGC AAACGAGAAG GCTGTGGATT TGATTATTGT 
ACGAAGTGTC TCTGTAATTA TCATACTACT AAAGACTGTT CAGATGGCAA GCTCCTCAAA 
GCCAGTTGTA AAATAGGTCC CCTGCCTGGT ACAAAGAAAA GCAAAAAGAA TTTACGAAGA 
TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135994.1
CDS	382..1587
Translation	MKCDFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVQLETESKRLHNKENQHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENFGDSLQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNFRLQNIIGRKMGLECVDILSELFRRGLRHVLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQRVTENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL

Target ORF information:

RefSeq Version	NM_001142522.3
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 5 (FBXO5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142522.3

ORF Insert Sequence:

ATGAAGTGTG ATTTTAATTG TAACCATGTT CATTCCGGAC TTAAACTGGT AAAACCTGAT 
GACATTGGAA GACTAGTTTC CTACACCCCT GCATATTTGG AAGGTTCCTG TAAAGACTGC 
ATTAAAGACT ATGAAAGGCT GTCATGTATT GGGTCACCGA TTGTGAGCCC TAGGATTGTA 
CAACTTGAAA CTGAAAGCAA GCGCTTGCAT AACAAGGAAA ATCAACATGT GCAACAGACA 
CTTAATAGTA CAAATGAAAT AGAAGCACTA GAGACCAGTA GACTTTATGA AGACAGTGGC 
TATTCCTCAT TTTCTCTACA AAGTGGCCTC AGTGAACATG AAGAAGGTAG CCTCCTGGAG 
GAGAATTTCG GTGACAGTCT ACAATCCTGC CTGCTACAAA TACAAAGCCC AGACCAATAT 
CCCAACAAAA ACTTGCTGCC AGTTCTTCAT TTTGAAAAAG TGGTTTGTTC AACATTAAAA 
AAGAATGCAA AACGAAATCC TAAAGTAGAT CGGGAGATGC TGAAGGAAAT TATAGCCAGA 
GGAAATTTTA GACTGCAGAA TATAATTGGC AGAAAAATGG GCCTAGAATG TGTAGATATT 
CTCAGCGAAC TCTTTCGAAG GGGACTCAGA CATGTCTTAG CAACTATTTT AGCACAACTC 
AGTGACATGG ACTTAATCAA TGTGTCTAAA GTGAGCACAA CTTGGAAGAA GATCCTAGAA 
GATGATAAGG GGGCATTCCA GTTGTACAGT AAAGCAATAC AAAGAGTTAC CGAAAACAAC 
AATAAATTTT CACCTCATGC TTCAACCAGA GAATATGTTA TGTTCAGAAC CCCACTGGCT 
TCTGTTCAGA AATCAGCAGC CCAGACTTCT CTCAAAAAAG ATGCTCAAAC CAAGTTATCC 
AATCAAGGTG ATCAGAAAGG TTCTACTTAT AGTCGACACA ATGAATTCTC TGAGGTTGCC 
AAGACATTGA AAAAGAACGA AAGCCTCAAA GCCTGTATTC GCTGTAATTC ACCTGCAAAA 
TATGATTGCT ATTTACAACG GGCAACCTGC AAACGAGAAG GCTGTGGATT TGATTATTGT 
ACGAAGTGTC TCTGTAATTA TCATACTACT AAAGACTGTT CAGATGGCAA GCTCCTCAAA 
GCCAGTTGTA AAATAGGTCC CCTGCCTGGT ACAAAGAAAA GCAAAAAGAA TTTACGAAGA 
TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis.
Oncogene35(41)5446-5455(2016 Oct)
Vaidyanathan S,Cato K,Tang L,Pavey S,Haass NK,Gabrielli BG,Duijf PH

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FBXO5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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