FBXO22 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FBXO22
Entrez Gene ID	26263
Full Name	F-box protein 22
Synonyms	FBX22,FISTC1
General protein information	Preferred Names F-box protein 22 Names F-box only protein 22 F-box protein FBX22p44 FIST domain containing 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q24.2
Summary	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010].
Disorder MIM:	609096

mRNA and Protein(s)

mRNA	Protein	Name
XM_011521447.2	XP_011519749.1	F-box only protein 22 isoform X1
NM_147188.2	NP_671717.1	F-box only protein 22 isoform a
NM_012170.3	NP_036302.1	F-box only protein 22 isoform b
XM_011521447.3	XP_011519749.1	F-box only protein 22 isoform X1
NM_147188.3	NP_671717.1	F-box only protein 22 isoform a

Pathways from BioSystems

Homologies

Homo sapiens (human)	FBXO22	NP_671717.1
Pan troglodytes (chimpanzee)	FBXO22	XP_001145977.1
Mus musculus (house mouse)	Fbxo22	NP_082325.2
Gallus gallus (chicken)	FBXO22	NP_001025716.1
Xenopus tropicalis (tropical clawed frog)	fbxo22	NP_001072897.1
Canis lupus familiaris (dog)	FBXO22	XP_544796.2
Rattus norvegicus (Norway rat)	Fbxo22	NP_001032859.1
Danio rerio (zebrafish)	fbxo22	NP_001025277.1
	FBXO22	XP_001104297.1
Bos taurus (cattle)	FBXO22	NP_001092544.1

Gene Ontology
Bibliography

Related articles in PubMed

F-Box Protein FBXO22 Mediates Polyubiquitination and Degradation of CD147 to Reverse Cisplatin Resistance of Tumor Cells.
Wu B, Liu ZY, Cui J, Yang XM, Jing L, Zhou Y, Chen ZN, Jiang JL
International journal of molecular sciences18(1)(2017 Jan)

A High-Density Map for Navigating the Human Polycomb Complexome.
Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M, Beisel C
Cell reports17(2)583-595(2016 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that FBXO22 mediated the polyubiquitination and degradation of CD147 by interacting with CD147 intracellular domain (CD147-ICD).
Title: F-Box Protein FBXO22 Mediates Polyubiquitination and Degradation of CD147 to Reverse Cisplatin Resistance of Tumor Cells.

Results indicate that SCF(Fbxo22)-KDM4A is an E3 ubiquitin ligase that targets methylated p53 and regulates key senescent processes.
Title: SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.

Authors demonstrate that F-box only protein 22 (FBXO22) interacts with and thereby destabilizes KLF4 via polyubiquitination. As a result, FBXO22 could promote HCC cells proliferation.
Title: F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression.

FBXO22 protein is required for optimal synthesis of NMDA receptor coagonist D-serine by interacting with serine racemase, activating it, and preventing its targeting to membranes.
Title: FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.

we determined that the phage-encoded GogB effector protein in Salmonella targets the host SCF E3 type ubiquitin ligase through an interaction with Skp1 and the human F-box only 22 (FBXO22) protein
Title: GogB is an anti-inflammatory effector that limits tissue damage during Salmonella infection through interaction with human FBXO22 and Skp1.

The following FBXO22 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FBXO22 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11465	NM_147188.3 Latest version!	Homo sapiens F-box protein 22 (FBXO22), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu66911	XM_011521447.3 Latest version!	Homo sapiens F-box protein 22 (FBXO22), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu11955	NM_012170.3 Latest version!	Homo sapiens F-box protein 22 (FBXO22), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu66911	XM_011521447.2	Homo sapiens F-box protein 22 (FBXO22), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu11465	NM_147188.2	Homo sapiens F-box protein 22 (FBXO22), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FBXO22 ( NM_147188.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_671717.1 Homo sapiens F-box protein 22 (FBXO22), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11465
Clone ID Related Accession (Same CDS sequence)	NM_147188.2 , NM_147188.3
Accession Version	NM_147188.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1212bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	F-box only protein 22 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC020204.1, AC027104.6 and AW292124.1. On Dec 9, 2010 this sequence version replaced NM_147188.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020204.1, SRR1660807.77979.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCGG TAGGCTGCTG CGGCGAGTGC CGCGGCTCCT CCGTAGACCC GCGGAGCACC 
TTCGTGTTGA GTAACCTGGC GGAGGTGGTG GAGCGTGTGC TCACCTTCCT GCCCGCCAAG 
GCGTTGCTGC GGGTGGCCTG CGTGTGCCGC TTATGGAGGG AGTGTGTGCG CAGAGTATTG 
CGGACCCATC GGAGCGTAAC CTGGATCTCC GCAGGCCTGG CGGAGGCCGG CCACCTGGAG 
GGGCATTGCT TGGTTCGCGT GGTAGCAGAG GAGCTTGAGA ATGTTCGCAT CTTACCACAT 
ACAGTTCTTT ACATGGCTGA TTCAGAAACT TTCATTAGTC TGGAAGAGTG TCGTGGCCAT 
AAGAGAGCAA GGAAAAGAAC TAGTATGGAA ACAGCACTTG CCCTTGAGAA GCTATTCCCC 
AAACAATGCC AAGTCCTTGG GATTGTGACC CCAGGAATTG TAGTGACTCC AATGGGATCA 
GGTAGCAATC GACCTCAGGA AATAGAAATT GGAGAATCTG GTTTTGCTTT ATTATTCCCT 
CAAATTGAAG GAATAAAAAT ACAACCCTTT CATTTTATTA AGGATCCAAA GAATTTAACA 
TTAGAAAGAC ATCAACTCAC TGAAGTAGGT CTTTTAGATA ACCCTGAACT TCGTGTGGTC 
CTTGTCTTTG GTTATAATTG CTGTAAGGTG GGAGCCAGTA ATTATCTGCA GCAAGTAGTC 
AGCACTTTCA GTGATATGAA TATCATCTTG GCTGGAGGCC AGGTGGACAA CCTGTCATCA 
CTGACTTCTG AAAAGAACCC TCTGGATATT GATGCCTCGG GTGTGGTTGG ACTGTCATTT 
AGTGGACACC GAATCCAGAG TGCCACTGTG CTCCTCAACG AGGACGTCAG TGATGAGAAG 
ACTGCTGAGG CTGCGATGCA GCGCCTCAAA GCGGCCAACA TTCCAGAGCA TAACACCATT 
GGCTTCATGT TTGCATGCGT TGGCAGGGGC TTTCAGTATT ACAGAGCCAA GGGGAATGTT 
GAGGCTGATG CATTTAGAAA GTTTTTTCCT AGTGTTCCCT TATTCGGCTT CTTTGGAAAT 
GGAGAAATTG GATGTGATCG GATAGTCACT GGGAACTTTA TATTGAGGAA ATGTAATGAG 
GTAAAAGATG ATGATCTGTT TCATAGCTAT ACAACAATAA TGGCACTCAT ACATCTGGGG 
TCATCTAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_671717.1
CDS	106..1317
Translation	MEPVGCCGECRGSSVDPRSTFVLSNLAEVVERVLTFLPAKALLRVACVCRLWRECVRRVLRTHRSVTWISAGLAEAGHLEGHCLVRVVAEELENVRILPHTVLYMADSETFISLEECRGHKRARKRTSMETALALEKLFPKQCQVLGIVTPGIVVTPMGSGSNRPQEIEIGESGFALLFPQIEGIKIQPFHFIKDPKNLTLERHQLTEVGLLDNPELRVVLVFGYNCCKVGASNYLQQVVSTFSDMNIILAGGQVDNLSSLTSEKNPLDIDASGVVGLSFSGHRIQSATVLLNEDVSDEKTAEAAMQRLKAANIPEHNTIGFMFACVGRGFQYYRAKGNVEADAFRKFFPSVPLFGFFGNGEIGCDRIVTGNFILRKCNEVKDDDLFHSYTTIMALIHLGSSK

Target ORF information:

RefSeq Version	NM_147188.2
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 22 (FBXO22), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_147188.2

ORF Insert Sequence:

ATGGAGCCGG TAGGCTGCTG CGGCGAGTGC CGCGGCTCCT CCGTAGACCC GCGGAGCACC 
TTCGTGTTGA GTAACCTGGC GGAGGTGGTG GAGCGTGTGC TCACCTTCCT GCCCGCCAAG 
GCGTTGCTGC GGGTGGCCTG CGTGTGCCGC TTATGGAGGG AGTGTGTGCG CAGAGTATTG 
CGGACCCATC GGAGCGTAAC CTGGATCTCC GCAGGCCTGG CGGAGGCCGG CCACCTGGAG 
GGGCATTGCT TGGTTCGCGT GGTAGCAGAG GAGCTTGAGA ATGTTCGCAT CTTACCACAT 
ACAGTTCTTT ACATGGCTGA TTCAGAAACT TTCATTAGTC TGGAAGAGTG TCGTGGCCAT 
AAGAGAGCAA GGAAAAGAAC TAGTATGGAA ACAGCACTTG CCCTTGAGAA GCTATTCCCC 
AAACAATGCC AAGTCCTTGG GATTGTGACC CCAGGAATTG TAGTGACTCC AATGGGATCA 
GGTAGCAATC GACCTCAGGA AATAGAAATT GGAGAATCTG GTTTTGCTTT ATTATTCCCT 
CAAATTGAAG GAATAAAAAT ACAACCCTTT CATTTTATTA AGGATCCAAA GAATTTAACA 
TTAGAAAGAC ATCAACTCAC TGAAGTAGGT CTTTTAGATA ACCCTGAACT TCGTGTGGTC 
CTTGTCTTTG GTTATAATTG CTGTAAGGTG GGAGCCAGTA ATTATCTGCA GCAAGTAGTC 
AGCACTTTCA GTGATATGAA TATCATCTTG GCTGGAGGCC AGGTGGACAA CCTGTCATCA 
CTGACTTCTG AAAAGAACCC TCTGGATATT GATGCCTCGG GTGTGGTTGG ACTGTCATTT 
AGTGGACACC GAATCCAGAG TGCCACTGTG CTCCTCAACG AGGACGTCAG TGATGAGAAG 
ACTGCTGAGG CTGCGATGCA GCGCCTCAAA GCGGCCAACA TTCCAGAGCA TAACACCATT 
GGCTTCATGT TTGCATGCGT TGGCAGGGGC TTTCAGTATT ACAGAGCCAA GGGGAATGTT 
GAGGCTGATG CATTTAGAAA GTTTTTTCCT AGTGTTCCCT TATTCGGCTT CTTTGGAAAT 
GGAGAAATTG GATGTGATCG GATAGTCACT GGGAACTTTA TATTGAGGAA ATGTAATGAG 
GTAAAAGATG ATGATCTGTT TCATAGCTAT ACAACAATAA TGGCACTCAT ACATCTGGGG 
TCATCTAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXO22 ( NM_147188.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_671717.1 Homo sapiens F-box protein 22 (FBXO22), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11465
Clone ID Related Accession (Same CDS sequence)	NM_147188.2 , NM_147188.3
Accession Version	NM_147188.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1212bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	F-box only protein 22 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC020204.1, AC027104.6 and AW292124.1. On Nov 23, 2018 this sequence version replaced NM_147188.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.206369.1, SRR1803615.239091.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000308275.8/ ENSP00000307833.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCCGG TAGGCTGCTG CGGCGAGTGC CGCGGCTCCT CCGTAGACCC GCGGAGCACC 
TTCGTGTTGA GTAACCTGGC GGAGGTGGTG GAGCGTGTGC TCACCTTCCT GCCCGCCAAG 
GCGTTGCTGC GGGTGGCCTG CGTGTGCCGC TTATGGAGGG AGTGTGTGCG CAGAGTATTG 
CGGACCCATC GGAGCGTAAC CTGGATCTCC GCAGGCCTGG CGGAGGCCGG CCACCTGGAG 
GGGCATTGCT TGGTTCGCGT GGTAGCAGAG GAGCTTGAGA ATGTTCGCAT CTTACCACAT 
ACAGTTCTTT ACATGGCTGA TTCAGAAACT TTCATTAGTC TGGAAGAGTG TCGTGGCCAT 
AAGAGAGCAA GGAAAAGAAC TAGTATGGAA ACAGCACTTG CCCTTGAGAA GCTATTCCCC 
AAACAATGCC AAGTCCTTGG GATTGTGACC CCAGGAATTG TAGTGACTCC AATGGGATCA 
GGTAGCAATC GACCTCAGGA AATAGAAATT GGAGAATCTG GTTTTGCTTT ATTATTCCCT 
CAAATTGAAG GAATAAAAAT ACAACCCTTT CATTTTATTA AGGATCCAAA GAATTTAACA 
TTAGAAAGAC ATCAACTCAC TGAAGTAGGT CTTTTAGATA ACCCTGAACT TCGTGTGGTC 
CTTGTCTTTG GTTATAATTG CTGTAAGGTG GGAGCCAGTA ATTATCTGCA GCAAGTAGTC 
AGCACTTTCA GTGATATGAA TATCATCTTG GCTGGAGGCC AGGTGGACAA CCTGTCATCA 
CTGACTTCTG AAAAGAACCC TCTGGATATT GATGCCTCGG GTGTGGTTGG ACTGTCATTT 
AGTGGACACC GAATCCAGAG TGCCACTGTG CTCCTCAACG AGGACGTCAG TGATGAGAAG 
ACTGCTGAGG CTGCGATGCA GCGCCTCAAA GCGGCCAACA TTCCAGAGCA TAACACCATT 
GGCTTCATGT TTGCATGCGT TGGCAGGGGC TTTCAGTATT ACAGAGCCAA GGGGAATGTT 
GAGGCTGATG CATTTAGAAA GTTTTTTCCT AGTGTTCCCT TATTCGGCTT CTTTGGAAAT 
GGAGAAATTG GATGTGATCG GATAGTCACT GGGAACTTTA TATTGAGGAA ATGTAATGAG 
GTAAAAGATG ATGATCTGTT TCATAGCTAT ACAACAATAA TGGCACTCAT ACATCTGGGG 
TCATCTAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_671717.1
CDS	87..1298
Translation	MEPVGCCGECRGSSVDPRSTFVLSNLAEVVERVLTFLPAKALLRVACVCRLWRECVRRVLRTHRSVTWISAGLAEAGHLEGHCLVRVVAEELENVRILPHTVLYMADSETFISLEECRGHKRARKRTSMETALALEKLFPKQCQVLGIVTPGIVVTPMGSGSNRPQEIEIGESGFALLFPQIEGIKIQPFHFIKDPKNLTLERHQLTEVGLLDNPELRVVLVFGYNCCKVGASNYLQQVVSTFSDMNIILAGGQVDNLSSLTSEKNPLDIDASGVVGLSFSGHRIQSATVLLNEDVSDEKTAEAAMQRLKAANIPEHNTIGFMFACVGRGFQYYRAKGNVEADAFRKFFPSVPLFGFFGNGEIGCDRIVTGNFILRKCNEVKDDDLFHSYTTIMALIHLGSSK

Target ORF information:

RefSeq Version	NM_147188.3
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 22 (FBXO22), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_147188.3

ORF Insert Sequence:

ATGGAGCCGG TAGGCTGCTG CGGCGAGTGC CGCGGCTCCT CCGTAGACCC GCGGAGCACC 
TTCGTGTTGA GTAACCTGGC GGAGGTGGTG GAGCGTGTGC TCACCTTCCT GCCCGCCAAG 
GCGTTGCTGC GGGTGGCCTG CGTGTGCCGC TTATGGAGGG AGTGTGTGCG CAGAGTATTG 
CGGACCCATC GGAGCGTAAC CTGGATCTCC GCAGGCCTGG CGGAGGCCGG CCACCTGGAG 
GGGCATTGCT TGGTTCGCGT GGTAGCAGAG GAGCTTGAGA ATGTTCGCAT CTTACCACAT 
ACAGTTCTTT ACATGGCTGA TTCAGAAACT TTCATTAGTC TGGAAGAGTG TCGTGGCCAT 
AAGAGAGCAA GGAAAAGAAC TAGTATGGAA ACAGCACTTG CCCTTGAGAA GCTATTCCCC 
AAACAATGCC AAGTCCTTGG GATTGTGACC CCAGGAATTG TAGTGACTCC AATGGGATCA 
GGTAGCAATC GACCTCAGGA AATAGAAATT GGAGAATCTG GTTTTGCTTT ATTATTCCCT 
CAAATTGAAG GAATAAAAAT ACAACCCTTT CATTTTATTA AGGATCCAAA GAATTTAACA 
TTAGAAAGAC ATCAACTCAC TGAAGTAGGT CTTTTAGATA ACCCTGAACT TCGTGTGGTC 
CTTGTCTTTG GTTATAATTG CTGTAAGGTG GGAGCCAGTA ATTATCTGCA GCAAGTAGTC 
AGCACTTTCA GTGATATGAA TATCATCTTG GCTGGAGGCC AGGTGGACAA CCTGTCATCA 
CTGACTTCTG AAAAGAACCC TCTGGATATT GATGCCTCGG GTGTGGTTGG ACTGTCATTT 
AGTGGACACC GAATCCAGAG TGCCACTGTG CTCCTCAACG AGGACGTCAG TGATGAGAAG 
ACTGCTGAGG CTGCGATGCA GCGCCTCAAA GCGGCCAACA TTCCAGAGCA TAACACCATT 
GGCTTCATGT TTGCATGCGT TGGCAGGGGC TTTCAGTATT ACAGAGCCAA GGGGAATGTT 
GAGGCTGATG CATTTAGAAA GTTTTTTCCT AGTGTTCCCT TATTCGGCTT CTTTGGAAAT 
GGAGAAATTG GATGTGATCG GATAGTCACT GGGAACTTTA TATTGAGGAA ATGTAATGAG 
GTAAAAGATG ATGATCTGTT TCATAGCTAT ACAACAATAA TGGCACTCAT ACATCTGGGG 
TCATCTAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXO22 ( XM_011521447.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011519749.1 Homo sapiens F-box protein 22 (FBXO22), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu66911
Clone ID Related Accession (Same CDS sequence)	XM_011521447.2 , XM_011521447.3
Accession Version	XM_011521447.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	F-box only protein 22 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011521447.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGATT CAGAAACTTT CATTAGTCTG GAAGAGTGTC GTGGCCATAA GAGAGCAAGG 
AAAAGAACTA GTATGGAAAC AGCACTTGCC CTTGAGAAGC TATTCCCCAA ACAATGCCAA 
GTCCTTGGGA TTGTGACCCC AGGAATTGTA GTGACTCCAA TGGGATCAGG TAGCAATCGA 
CCTCAGGAAA TAGAAATTGG AGAATCTGGT TTTGCTTTAT TATTCCCTCA AATTGAAGGA 
ATAAAAATAC AACCCTTTCA TTTTATTAAG GATCCAAAGA ATTTAACATT AGAAAGACAT 
CAACTCACTG AAGTAGGTCT TTTAGATAAC CCTGAACTTC GTGTGGTCCT TGTCTTTGGT 
TATAATTGCT GTAAGGTGGG AGCCAGTAAT TATCTGCAGC AAGTAGTCAG CACTTTCAGT 
GATATGAATA TCATCTTGGC TGGAGGCCAG GTGGACAACC TGTCATCACT GACTTCTGAA 
AAGAACCCTC TGGATATTGA TGCCTCGGGT GTGGTTGGAC TGTCATTTAG TGGACACCGA 
ATCCAGAGTG CCACTGTGCT CCTCAACGAG GACGTCAGTG ATGAGAAGAC TGCTGAGGCT 
GCGATGCAGC GCCTCAAAGC GGCCAACATT CCAGAGCATA ACACCATTGG CTTCATGTTT 
GCATGCGTTG GCAGGGGCTT TCAGTATTAC AGAGCCAAGG GGAATGTTGA GGCTGATGCA 
TTTAGAAAGT TTTTTCCTAG TGTTCCCTTA TTCGGCTTCT TTGGAAATGG AGAAATTGGA 
TGTGATCGGA TAGTCACTGG GAACTTTATA TTGAGGAAAT GTAATGAGGT AAAAGATGAT 
GATCTGTTTC ATAGCTATAC AACAATAATG GCACTCATAC ATCTGGGGTC ATCTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011519749.1
CDS	418..1317
Translation	MADSETFISLEECRGHKRARKRTSMETALALEKLFPKQCQVLGIVTPGIVVTPMGSGSNRPQEIEIGESGFALLFPQIEGIKIQPFHFIKDPKNLTLERHQLTEVGLLDNPELRVVLVFGYNCCKVGASNYLQQVVSTFSDMNIILAGGQVDNLSSLTSEKNPLDIDASGVVGLSFSGHRIQSATVLLNEDVSDEKTAEAAMQRLKAANIPEHNTIGFMFACVGRGFQYYRAKGNVEADAFRKFFPSVPLFGFFGNGEIGCDRIVTGNFILRKCNEVKDDDLFHSYTTIMALIHLGSSK

Target ORF information:

RefSeq Version	XM_011521447.2
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 22 (FBXO22), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011521447.2

ORF Insert Sequence:

ATGGCTGATT CAGAAACTTT CATTAGTCTG GAAGAGTGTC GTGGCCATAA GAGAGCAAGG 
AAAAGAACTA GTATGGAAAC AGCACTTGCC CTTGAGAAGC TATTCCCCAA ACAATGCCAA 
GTCCTTGGGA TTGTGACCCC AGGAATTGTA GTGACTCCAA TGGGATCAGG TAGCAATCGA 
CCTCAGGAAA TAGAAATTGG AGAATCTGGT TTTGCTTTAT TATTCCCTCA AATTGAAGGA 
ATAAAAATAC AACCCTTTCA TTTTATTAAG GATCCAAAGA ATTTAACATT AGAAAGACAT 
CAACTCACTG AAGTAGGTCT TTTAGATAAC CCTGAACTTC GTGTGGTCCT TGTCTTTGGT 
TATAATTGCT GTAAGGTGGG AGCCAGTAAT TATCTGCAGC AAGTAGTCAG CACTTTCAGT 
GATATGAATA TCATCTTGGC TGGAGGCCAG GTGGACAACC TGTCATCACT GACTTCTGAA 
AAGAACCCTC TGGATATTGA TGCCTCGGGT GTGGTTGGAC TGTCATTTAG TGGACACCGA 
ATCCAGAGTG CCACTGTGCT CCTCAACGAG GACGTCAGTG ATGAGAAGAC TGCTGAGGCT 
GCGATGCAGC GCCTCAAAGC GGCCAACATT CCAGAGCATA ACACCATTGG CTTCATGTTT 
GCATGCGTTG GCAGGGGCTT TCAGTATTAC AGAGCCAAGG GGAATGTTGA GGCTGATGCA 
TTTAGAAAGT TTTTTCCTAG TGTTCCCTTA TTCGGCTTCT TTGGAAATGG AGAAATTGGA 
TGTGATCGGA TAGTCACTGG GAACTTTATA TTGAGGAAAT GTAATGAGGT AAAAGATGAT 
GATCTGTTTC ATAGCTATAC AACAATAATG GCACTCATAC ATCTGGGGTC ATCTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXO22 ( XM_011521447.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011519749.1 Homo sapiens F-box protein 22 (FBXO22), transcript variant X1, mRNA.

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CloneID	OHu66911
Clone ID Related Accession (Same CDS sequence)	XM_011521447.2 , XM_011521447.3
Accession Version	XM_011521447.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	F-box only protein 22 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011521447.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGATT CAGAAACTTT CATTAGTCTG GAAGAGTGTC GTGGCCATAA GAGAGCAAGG 
AAAAGAACTA GTATGGAAAC AGCACTTGCC CTTGAGAAGC TATTCCCCAA ACAATGCCAA 
GTCCTTGGGA TTGTGACCCC AGGAATTGTA GTGACTCCAA TGGGATCAGG TAGCAATCGA 
CCTCAGGAAA TAGAAATTGG AGAATCTGGT TTTGCTTTAT TATTCCCTCA AATTGAAGGA 
ATAAAAATAC AACCCTTTCA TTTTATTAAG GATCCAAAGA ATTTAACATT AGAAAGACAT 
CAACTCACTG AAGTAGGTCT TTTAGATAAC CCTGAACTTC GTGTGGTCCT TGTCTTTGGT 
TATAATTGCT GTAAGGTGGG AGCCAGTAAT TATCTGCAGC AAGTAGTCAG CACTTTCAGT 
GATATGAATA TCATCTTGGC TGGAGGCCAG GTGGACAACC TGTCATCACT GACTTCTGAA 
AAGAACCCTC TGGATATTGA TGCCTCGGGT GTGGTTGGAC TGTCATTTAG TGGACACCGA 
ATCCAGAGTG CCACTGTGCT CCTCAACGAG GACGTCAGTG ATGAGAAGAC TGCTGAGGCT 
GCGATGCAGC GCCTCAAAGC GGCCAACATT CCAGAGCATA ACACCATTGG CTTCATGTTT 
GCATGCGTTG GCAGGGGCTT TCAGTATTAC AGAGCCAAGG GGAATGTTGA GGCTGATGCA 
TTTAGAAAGT TTTTTCCTAG TGTTCCCTTA TTCGGCTTCT TTGGAAATGG AGAAATTGGA 
TGTGATCGGA TAGTCACTGG GAACTTTATA TTGAGGAAAT GTAATGAGGT AAAAGATGAT 
GATCTGTTTC ATAGCTATAC AACAATAATG GCACTCATAC ATCTGGGGTC ATCTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011519749.1
CDS	418..1317
Translation	MADSETFISLEECRGHKRARKRTSMETALALEKLFPKQCQVLGIVTPGIVVTPMGSGSNRPQEIEIGESGFALLFPQIEGIKIQPFHFIKDPKNLTLERHQLTEVGLLDNPELRVVLVFGYNCCKVGASNYLQQVVSTFSDMNIILAGGQVDNLSSLTSEKNPLDIDASGVVGLSFSGHRIQSATVLLNEDVSDEKTAEAAMQRLKAANIPEHNTIGFMFACVGRGFQYYRAKGNVEADAFRKFFPSVPLFGFFGNGEIGCDRIVTGNFILRKCNEVKDDDLFHSYTTIMALIHLGSSK

Target ORF information:

RefSeq Version	XM_011521447.3
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 22 (FBXO22), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011521447.3

ORF Insert Sequence:

ATGGCTGATT CAGAAACTTT CATTAGTCTG GAAGAGTGTC GTGGCCATAA GAGAGCAAGG 
AAAAGAACTA GTATGGAAAC AGCACTTGCC CTTGAGAAGC TATTCCCCAA ACAATGCCAA 
GTCCTTGGGA TTGTGACCCC AGGAATTGTA GTGACTCCAA TGGGATCAGG TAGCAATCGA 
CCTCAGGAAA TAGAAATTGG AGAATCTGGT TTTGCTTTAT TATTCCCTCA AATTGAAGGA 
ATAAAAATAC AACCCTTTCA TTTTATTAAG GATCCAAAGA ATTTAACATT AGAAAGACAT 
CAACTCACTG AAGTAGGTCT TTTAGATAAC CCTGAACTTC GTGTGGTCCT TGTCTTTGGT 
TATAATTGCT GTAAGGTGGG AGCCAGTAAT TATCTGCAGC AAGTAGTCAG CACTTTCAGT 
GATATGAATA TCATCTTGGC TGGAGGCCAG GTGGACAACC TGTCATCACT GACTTCTGAA 
AAGAACCCTC TGGATATTGA TGCCTCGGGT GTGGTTGGAC TGTCATTTAG TGGACACCGA 
ATCCAGAGTG CCACTGTGCT CCTCAACGAG GACGTCAGTG ATGAGAAGAC TGCTGAGGCT 
GCGATGCAGC GCCTCAAAGC GGCCAACATT CCAGAGCATA ACACCATTGG CTTCATGTTT 
GCATGCGTTG GCAGGGGCTT TCAGTATTAC AGAGCCAAGG GGAATGTTGA GGCTGATGCA 
TTTAGAAAGT TTTTTCCTAG TGTTCCCTTA TTCGGCTTCT TTGGAAATGG AGAAATTGGA 
TGTGATCGGA TAGTCACTGG GAACTTTATA TTGAGGAAAT GTAATGAGGT AAAAGATGAT 
GATCTGTTTC ATAGCTATAC AACAATAATG GCACTCATAC ATCTGGGGTC ATCTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXO22 ( NM_012170.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036302.1 Homo sapiens F-box protein 22 (FBXO22), transcript variant 2, mRNA.

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CloneID	OHu11955
Clone ID Related Accession (Same CDS sequence)	NM_012170.3
Accession Version	NM_012170.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	F-box only protein 22 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC020204.1, AK024048.1, AL705285.1 and AC027104.6. On Dec 9, 2010 this sequence version replaced NM_012170.2. Transcript Variant: This variant (2) contains a distinct 3' coding sequence and 3' UTR compared to variant 1. This results in a shorter isoform (b) with a distinct C-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.108780.1, AK024048.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCGG TAGGCTGCTG CGGCGAGTGC CGCGGCTCCT CCGTAGACCC GCGGAGCACC 
TTCGTGTTGA GTAACCTGGC GGAGGTGGTG GAGCGTGTGC TCACCTTCCT GCCCGCCAAG 
GCGTTGCTGC GGGTGGCCTG CGTGTGCCGC TTATGGAGGG AGTGTGTGCG CAGAGTATTG 
CGGACCCATC GGAGCGTAAC CTGGATCTCC GCAGGCCTGG CGGAGGCCGG CCACCTGGAG 
GGGCATTGCT TGGTTCGCGT GGTAGCAGAG GAGCTTGAGA ATGTTCGCAT CTTACCACAT 
ACAGTTCTTT ACATGGCTGA TTCAGAAACT TTCATTAGTC TGGAAGAGTG TCGTGGCCAT 
AAGAGAGCAA GGAAAAGAAC TAGTATGGAA ACAGCACTTG CCCTTGAGAA GCTATTCCCC 
AAACAATGCC AAGTCCTTGG GATTGTGACC CCAGGAATTG TAGTGACTCC AATGGGATCA 
GGTAGCAATC GACCTCAGGA AATAGAAATT GGAGAATCTG GTTTTGCTTT ATTATTCCCT 
CAAATTGAAG GAATAAAAAT ACAACCCTTT CATTTTATTA AGGATCCAAA GAATTTAACA 
TTAGAAAGAC ATCAACTCAC TGAAGTAGGT CTTTTAGATA ACCCTGAACT TCGTGTGGTC 
CTTGTCTTTG GTTATAATTG CTGTAAGGTG GGAGCCAGTA ATTATCTGCA GCAAGTAGTC 
AGCACTTTCA GTGATATGAA TATCATCTTG GCTGGAGGCC AGGTGGACAA CCTGTCATCA 
CTGACTTCTG AAAAGTATGT CTTGTGTGCT TCTGATTTCG TCTGTGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036302.1
CDS	106..936
Translation	MEPVGCCGECRGSSVDPRSTFVLSNLAEVVERVLTFLPAKALLRVACVCRLWRECVRRVLRTHRSVTWISAGLAEAGHLEGHCLVRVVAEELENVRILPHTVLYMADSETFISLEECRGHKRARKRTSMETALALEKLFPKQCQVLGIVTPGIVVTPMGSGSNRPQEIEIGESGFALLFPQIEGIKIQPFHFIKDPKNLTLERHQLTEVGLLDNPELRVVLVFGYNCCKVGASNYLQQVVSTFSDMNIILAGGQVDNLSSLTSEKYVLCASDFVCE

Target ORF information:

RefSeq Version	NM_012170.3
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 22 (FBXO22), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012170.3

ORF Insert Sequence:

ATGGAGCCGG TAGGCTGCTG CGGCGAGTGC CGCGGCTCCT CCGTAGACCC GCGGAGCACC 
TTCGTGTTGA GTAACCTGGC GGAGGTGGTG GAGCGTGTGC TCACCTTCCT GCCCGCCAAG 
GCGTTGCTGC GGGTGGCCTG CGTGTGCCGC TTATGGAGGG AGTGTGTGCG CAGAGTATTG 
CGGACCCATC GGAGCGTAAC CTGGATCTCC GCAGGCCTGG CGGAGGCCGG CCACCTGGAG 
GGGCATTGCT TGGTTCGCGT GGTAGCAGAG GAGCTTGAGA ATGTTCGCAT CTTACCACAT 
ACAGTTCTTT ACATGGCTGA TTCAGAAACT TTCATTAGTC TGGAAGAGTG TCGTGGCCAT 
AAGAGAGCAA GGAAAAGAAC TAGTATGGAA ACAGCACTTG CCCTTGAGAA GCTATTCCCC 
AAACAATGCC AAGTCCTTGG GATTGTGACC CCAGGAATTG TAGTGACTCC AATGGGATCA 
GGTAGCAATC GACCTCAGGA AATAGAAATT GGAGAATCTG GTTTTGCTTT ATTATTCCCT 
CAAATTGAAG GAATAAAAAT ACAACCCTTT CATTTTATTA AGGATCCAAA GAATTTAACA 
TTAGAAAGAC ATCAACTCAC TGAAGTAGGT CTTTTAGATA ACCCTGAACT TCGTGTGGTC 
CTTGTCTTTG GTTATAATTG CTGTAAGGTG GGAGCCAGTA ATTATCTGCA GCAAGTAGTC 
AGCACTTTCA GTGATATGAA TATCATCTTG GCTGGAGGCC AGGTGGACAA CCTGTCATCA 
CTGACTTCTG AAAAGTATGT CTTGTGTGCT TCTGATTTCG TCTGTGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

F-Box Protein FBXO22 Mediates Polyubiquitination and Degradation of CD147 to Reverse Cisplatin Resistance of Tumor Cells.
International journal of molecular sciences18(1)(2017 Jan)
Wu B,Liu ZY,Cui J,Yang XM,Jing L,Zhou Y,Chen ZN,Jiang JL

A High-Density Map for Navigating the Human Polycomb Complexome.
Cell reports17(2)583-595(2016 10)
Hauri S,Comoglio F,Seimiya M,Gerstung M,Glatter T,Hansen K,Aebersold R,Paro R,Gstaiger M,Beisel C

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FBXO22 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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