FBXO2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FBXO2
Entrez Gene ID	26232
Full Name	F-box protein 2
Synonyms	FBG1,FBX2,Fbs1,NFB42,OCP1
General protein information	Preferred Names F-box protein 2 Names F-box only protein 2 F-box gene 1 organ of Corti protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.22
Summary	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008].
Disorder MIM:	607112

mRNA and Protein(s)

mRNA	Protein	Name
NM_012168.5	NP_036300.2	F-box only protein 2
NM_012168.6	NP_036300.2	F-box only protein 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FBXO2	NP_001069037.1
Gallus gallus (chicken)	FBXO2	XP_004947571.1
Danio rerio (zebrafish)	zgc:175088	NP_001107270.1
Xenopus tropicalis (tropical clawed frog)	LOC101733128	XP_004916577.1
Mus musculus (house mouse)	Fbxo2	NP_789818.1
Homo sapiens (human)	FBXO2	NP_036300.2
Pan troglodytes (chimpanzee)	FBXO2	XP_514389.2
Canis lupus familiaris (dog)	FBXO2	XP_535406.3
Rattus norvegicus (Norway rat)	Fbxo2	NP_445963.1

Gene Ontology
Bibliography

Related articles in PubMed

FBXO2, a novel marker for metastasis in human gastric cancer.
Sun X, Wang T, Guan ZR, Zhang C, Chen Y, Jin J, Hua D
Biochemical and biophysical research communications495(3)2158-2164(2018 Jan)

Genetic Analysis of FBXO2, FBXO6, FBXO12, and FBXO41 Variants in Han Chinese Patients with Sporadic Parkinson's Disease.
Yuan L, Song Z, Deng X, Yang Z, Yang Y, Guo Y, Lu H, Deng H
Neuroscience bulletin33(5)510-514(2017 Oct)

An engineered high affinity Fbs1 carbohydrate binding protein for selective capture of N-glycans and N-glycopeptides.
Chen M, Shi X, Duke RM, Ruse CI, Dai N, Taron CH, Samuelson JC
Nature communications815487(2017 May)

SYVN1, NEDD8, and FBXO2 Proteins Regulate ?F508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation.
Ramachandran S, Osterhaus SR, Parekh KR, Jacobi AM, Behlke MA, McCray PB Jr
The Journal of biological chemistry291(49)25489-25504(2016 Dec)

A High-Density Map for Navigating the Human Polycomb Complexome.
Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M, Beisel C
Cell reports17(2)583-595(2016 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study provides new knowledge of the CFTR biosynthetic pathway. It suggests that SYVN1 and FBXO2 represent two distinct multiprotein complexes that may degrade DeltaF508-CFTR in airway epithelia and identifies a new role for NEDD8 in regulating DeltaF508-CFTR ubiquitination.
Title: SYVN1, NEDD8, and FBXO2 Proteins Regulate ?F508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation.

Structural analysis of a function-associated loop mutant of the substrate-recognition domain of Fbs1 ubiquitin ligase has been presented.
Title: Structural analysis of a function-associated loop mutant of the substrate-recognition domain of Fbs1 ubiquitin ligase.

FBG1 degrades A1AT-Z through a Beclin1-dependent arm of autophagy.
Title: FBG1 Is the Final Arbitrator of A1AT-Z Degradation.

Although the overall structure of FBG3 is similar to that of Fbs1, the residues that form the Fbs1 carbohydrate-binding pocket failed to be superposed with the corresponding residues of FBG3.
Title: The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3.

FBG1 is unique among known F-box proteins in that it contains a non-canonical D-Box within F-box domain, required for the growth arrest.
Title: FBG1 is a promiscuous ubiquitin ligase that sequesters APC2 and causes S-phase arrest.

The following FBXO2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FBXO2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12106	NM_012168.6 Latest version!	Homo sapiens F-box protein 2 (FBXO2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu12106	NM_012168.5	Homo sapiens F-box protein 2 (FBXO2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FBXO2 ( NM_012168.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_036300.2 Homo sapiens F-box protein 2 (FBXO2), mRNA.

Price & Availability↑

CloneID	OHu12106
Clone ID Related Accession (Same CDS sequence)	NM_012168.5 , NM_012168.6
Accession Version	NM_012168.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 891bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-29
Organism	Homo sapiens(human)
Product	F-box only protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP209877.1, BF967195.1, AF187318.1, AL031731.44, AW162121.1 and BE464909.1. On Jan 20, 2011 this sequence version replaced NM_012168.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279842.10280.1, ERR279856.3518.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGGAG ACGGTGACCC AGAGAGCGTG GGCCAGCCCG AGGAGGCAAG CCCGGAGGAG 
CAGCCAGAGG AGGCGAGTGC TGAGGAGGAG CGGCCGGAGG ACCAGCAGGA GGAGGAGGCG 
GCGGCCGCCG CCGCGTACCT GGACGAGCTG CCCGAGCCGC TGCTGCTGCG CGTGCTGGCC 
GCACTGCCGG CCGCCGAGCT GGTGCAGGCC TGCCGCCTGG TGTGCCTGCG CTGGAAGGAG 
CTGGTGGACG GCGCCCCGCT GTGGCTGCTC AAGTGCCAGC AGGAGGGGCT GGTGCCCGAG 
GGCGGCGTGG AGGAGGAGCG CGACCACTGG CAGCAGTTCT ACTTCCTGAG CAAGCGGCGC 
CGCAACCTTC TGCGTAACCC GTGTGGGGAA GAGGACTTGG AAGGCTGGTG TGACGTGGAG 
CATGGTGGGG ACGGCTGGAG GGTGGAGGAG CTGCCTGGAG ACAGTGGGGT GGAGTTCACC 
CACGATGAGA GCGTCAAGAA GTACTTCGCC TCCTCCTTTG AGTGGTGTCG CAAAGCACAG 
GTCATTGACC TGCAGGCTGA GGGCTACTGG GAGGAGCTGC TGGACACGAC TCAGCCGGCC 
ATCGTGGTGA AGGACTGGTA CTCGGGCCGC AGCGACGCTG GTTGCCTCTA CGAGCTCACC 
GTTAAGCTAC TGTCCGAGCA CGAGAACGTG CTGGCTGAGT TCAGCAGCGG GCAGGTGGCA 
GTGCCCCAAG ACAGTGACGG CGGGGGCTGG ATGGAGATCT CCCACACCTT CACCGACTAC 
GGGCCGGGCG TCCGCTTCGT CCGCTTCGAG CACGGGGGGC AGGACTCCGT CTACTGGAAG 
GGCTGGTTCG GGGCCCGGGT GACCAACAGC AGCGTGTGGG TAGAACCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036300.2
CDS	492..1382
Translation	MDGDGDPESVGQPEEASPEEQPEEASAEEERPEDQQEEEAAAAAAYLDELPEPLLLRVLAALPAAELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGGVEEERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWCDVEHGGDGWRVEELPGDSGVEFTHDESVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRSDAGCLYELTVKLLSEHENVLAEFSSGQVAVPQDSDGGGWMEISHTFTDYGPGVRFVRFEHGGQDSVYWKGWFGARVTNSSVWVEP

Target ORF information:

RefSeq Version	NM_012168.5
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 2 (FBXO2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012168.5

ORF Insert Sequence:

ATGGACGGAG ACGGTGACCC AGAGAGCGTG GGCCAGCCCG AGGAGGCAAG CCCGGAGGAG 
CAGCCAGAGG AGGCGAGTGC TGAGGAGGAG CGGCCGGAGG ACCAGCAGGA GGAGGAGGCG 
GCGGCCGCCG CCGCGTACCT GGACGAGCTG CCCGAGCCGC TGCTGCTGCG CGTGCTGGCC 
GCACTGCCGG CCGCCGAGCT GGTGCAGGCC TGCCGCCTGG TGTGCCTGCG CTGGAAGGAG 
CTGGTGGACG GCGCCCCGCT GTGGCTGCTC AAGTGCCAGC AGGAGGGGCT GGTGCCCGAG 
GGCGGCGTGG AGGAGGAGCG CGACCACTGG CAGCAGTTCT ACTTCCTGAG CAAGCGGCGC 
CGCAACCTTC TGCGTAACCC GTGTGGGGAA GAGGACTTGG AAGGCTGGTG TGACGTGGAG 
CATGGTGGGG ACGGCTGGAG GGTGGAGGAG CTGCCTGGAG ACAGTGGGGT GGAGTTCACC 
CACGATGAGA GCGTCAAGAA GTACTTCGCC TCCTCCTTTG AGTGGTGTCG CAAAGCACAG 
GTCATTGACC TGCAGGCTGA GGGCTACTGG GAGGAGCTGC TGGACACGAC TCAGCCGGCC 
ATCGTGGTGA AGGACTGGTA CTCGGGCCGC AGCGACGCTG GTTGCCTCTA CGAGCTCACC 
GTTAAGCTAC TGTCCGAGCA CGAGAACGTG CTGGCTGAGT TCAGCAGCGG GCAGGTGGCA 
GTGCCCCAAG ACAGTGACGG CGGGGGCTGG ATGGAGATCT CCCACACCTT CACCGACTAC 
GGGCCGGGCG TCCGCTTCGT CCGCTTCGAG CACGGGGGGC AGGACTCCGT CTACTGGAAG 
GGCTGGTTCG GGGCCCGGGT GACCAACAGC AGCGTGTGGG TAGAACCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXO2 ( NM_012168.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_036300.2 Homo sapiens F-box protein 2 (FBXO2), mRNA.

Price & Availability↑

CloneID	OHu12106
Clone ID Related Accession (Same CDS sequence)	NM_012168.5 , NM_012168.6
Accession Version	NM_012168.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 891bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	F-box only protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF187318.1, AL031731.44 and AW162121.1. On Nov 23, 2018 this sequence version replaced NM_012168.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC096747.1, SRR3476690.299589.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000354287.5/ ENSP00000346240.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACGGAG ACGGTGACCC AGAGAGCGTG GGCCAGCCCG AGGAGGCAAG CCCGGAGGAG 
CAGCCAGAGG AGGCGAGTGC TGAGGAGGAG CGGCCGGAGG ACCAGCAGGA GGAGGAGGCG 
GCGGCCGCCG CCGCGTACCT GGACGAGCTG CCCGAGCCGC TGCTGCTGCG CGTGCTGGCC 
GCACTGCCGG CCGCCGAGCT GGTGCAGGCC TGCCGCCTGG TGTGCCTGCG CTGGAAGGAG 
CTGGTGGACG GCGCCCCGCT GTGGCTGCTC AAGTGCCAGC AGGAGGGGCT GGTGCCCGAG 
GGCGGCGTGG AGGAGGAGCG CGACCACTGG CAGCAGTTCT ACTTCCTGAG CAAGCGGCGC 
CGCAACCTTC TGCGTAACCC GTGTGGGGAA GAGGACTTGG AAGGCTGGTG TGACGTGGAG 
CATGGTGGGG ACGGCTGGAG GGTGGAGGAG CTGCCTGGAG ACAGTGGGGT GGAGTTCACC 
CACGATGAGA GCGTCAAGAA GTACTTCGCC TCCTCCTTTG AGTGGTGTCG CAAAGCACAG 
GTCATTGACC TGCAGGCTGA GGGCTACTGG GAGGAGCTGC TGGACACGAC TCAGCCGGCC 
ATCGTGGTGA AGGACTGGTA CTCGGGCCGC AGCGACGCTG GTTGCCTCTA CGAGCTCACC 
GTTAAGCTAC TGTCCGAGCA CGAGAACGTG CTGGCTGAGT TCAGCAGCGG GCAGGTGGCA 
GTGCCCCAAG ACAGTGACGG CGGGGGCTGG ATGGAGATCT CCCACACCTT CACCGACTAC 
GGGCCGGGCG TCCGCTTCGT CCGCTTCGAG CACGGGGGGC AGGACTCCGT CTACTGGAAG 
GGCTGGTTCG GGGCCCGGGT GACCAACAGC AGCGTGTGGG TAGAACCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036300.2
CDS	90..980
Translation	MDGDGDPESVGQPEEASPEEQPEEASAEEERPEDQQEEEAAAAAAYLDELPEPLLLRVLAALPAAELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGGVEEERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWCDVEHGGDGWRVEELPGDSGVEFTHDESVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRSDAGCLYELTVKLLSEHENVLAEFSSGQVAVPQDSDGGGWMEISHTFTDYGPGVRFVRFEHGGQDSVYWKGWFGARVTNSSVWVEP

Target ORF information:

RefSeq Version	NM_012168.6
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 2 (FBXO2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012168.6

ORF Insert Sequence:

ATGGACGGAG ACGGTGACCC AGAGAGCGTG GGCCAGCCCG AGGAGGCAAG CCCGGAGGAG 
CAGCCAGAGG AGGCGAGTGC TGAGGAGGAG CGGCCGGAGG ACCAGCAGGA GGAGGAGGCG 
GCGGCCGCCG CCGCGTACCT GGACGAGCTG CCCGAGCCGC TGCTGCTGCG CGTGCTGGCC 
GCACTGCCGG CCGCCGAGCT GGTGCAGGCC TGCCGCCTGG TGTGCCTGCG CTGGAAGGAG 
CTGGTGGACG GCGCCCCGCT GTGGCTGCTC AAGTGCCAGC AGGAGGGGCT GGTGCCCGAG 
GGCGGCGTGG AGGAGGAGCG CGACCACTGG CAGCAGTTCT ACTTCCTGAG CAAGCGGCGC 
CGCAACCTTC TGCGTAACCC GTGTGGGGAA GAGGACTTGG AAGGCTGGTG TGACGTGGAG 
CATGGTGGGG ACGGCTGGAG GGTGGAGGAG CTGCCTGGAG ACAGTGGGGT GGAGTTCACC 
CACGATGAGA GCGTCAAGAA GTACTTCGCC TCCTCCTTTG AGTGGTGTCG CAAAGCACAG 
GTCATTGACC TGCAGGCTGA GGGCTACTGG GAGGAGCTGC TGGACACGAC TCAGCCGGCC 
ATCGTGGTGA AGGACTGGTA CTCGGGCCGC AGCGACGCTG GTTGCCTCTA CGAGCTCACC 
GTTAAGCTAC TGTCCGAGCA CGAGAACGTG CTGGCTGAGT TCAGCAGCGG GCAGGTGGCA 
GTGCCCCAAG ACAGTGACGG CGGGGGCTGG ATGGAGATCT CCCACACCTT CACCGACTAC 
GGGCCGGGCG TCCGCTTCGT CCGCTTCGAG CACGGGGGGC AGGACTCCGT CTACTGGAAG 
GGCTGGTTCG GGGCCCGGGT GACCAACAGC AGCGTGTGGG TAGAACCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FBXO2, a novel marker for metastasis in human gastric cancer.
Biochemical and biophysical research communications495(3)2158-2164(2018 Jan)
Sun X,Wang T,Guan ZR,Zhang C,Chen Y,Jin J,Hua D

Genetic Analysis of FBXO2, FBXO6, FBXO12, and FBXO41 Variants in Han Chinese Patients with Sporadic Parkinson's Disease.
Neuroscience bulletin33(5)510-514(2017 Oct)
Yuan L,Song Z,Deng X,Yang Z,Yang Y,Guo Y,Lu H,Deng H

An engineered high affinity Fbs1 carbohydrate binding protein for selective capture of N-glycans and N-glycopeptides.
Nature communications815487(2017 May)
Chen M,Shi X,Duke RM,Ruse CI,Dai N,Taron CH,Samuelson JC

SYVN1, NEDD8, and FBXO2 Proteins Regulate ?F508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation.
The Journal of biological chemistry291(49)25489-25504(2016 Dec)
Ramachandran S,Osterhaus SR,Parekh KR,Jacobi AM,Behlke MA,McCray PB Jr

A High-Density Map for Navigating the Human Polycomb Complexome.
Cell reports17(2)583-595(2016 10)
Hauri S,Comoglio F,Seimiya M,Gerstung M,Glatter T,Hansen K,Aebersold R,Paro R,Gstaiger M,Beisel C

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FBXO2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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