FBXL3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FBXL3
Entrez Gene ID	26224
Full Name	F-box and leucine rich repeat protein 3
Synonyms	FBL3,FBL3A,FBXL3A
General protein information	Preferred Names F-box and leucine rich repeat protein 3 Names F-box/LRR-repeat protein 3 F-box and leucine-rich repeat protein 3A F-box protein Fbl3a F-box/LRR-repeat protein 3A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q22.3
Summary	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008].
Disorder MIM:	605653

mRNA and Protein(s)

mRNA	Protein	Name
XM_005266337.2	XP_005266394.1	F-box/LRR-repeat protein 3 isoform X2
NM_012158.3	NP_036290.1	F-box/LRR-repeat protein 3
XM_017020538.2	XP_016876027.1	F-box/LRR-repeat protein 3 isoform X3
NM_012158.4	NP_036290.1	F-box/LRR-repeat protein 3
XM_005266337.3	XP_005266394.1	F-box/LRR-repeat protein 3 isoform X2
XM_017020538.1	XP_016876027.1	F-box/LRR-repeat protein 3 isoform X3
NM_012158.2	NP_036290.1	F-box/LRR-repeat protein 3
XM_005266336.1	XP_005266393.1	F-box/LRR-repeat protein 3 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	FBXL3	NP_036290.1
Rattus norvegicus (Norway rat)	Fbxl3	NP_001094038.1
Danio rerio (zebrafish)	LOC504112	XP_002663386.1
Xenopus tropicalis (tropical clawed frog)	fbxl3	NP_001016128.1
Mus musculus (house mouse)	Fbxl3	NP_056637.1
Danio rerio (zebrafish)	fbxl3a	NP_001005773.2
Pan troglodytes (chimpanzee)	FBXL3	XP_522774.2
Canis lupus familiaris (dog)	FBXL3	XP_542618.2
Gallus gallus (chicken)	FBXL3	XP_425611.2

Gene Ontology
Bibliography

Related articles in PubMed

miR-181d and c-myc-mediated inhibition of CRY2 and FBXL3 reprograms metabolism in colorectal cancer.
Guo X, Zhu Y, Hong X, Zhang M, Qiu X, Wang Z, Qi Z, Hong X
Cell death & disease8(7)e2958(2017 Jul)

CRY2 and FBXL3 Cooperatively Degrade c-MYC.
Huber AL, Papp SJ, Chan AB, Henriksson E, Jordan SD, Kriebs A, Nguyen M, Wallace M, Li Z, Metallo CM, Lamia KA
Molecular cell64(4)774-789(2016 Nov)

A Cryptochrome 2 mutation yields advanced sleep phase in humans.
Hirano A, Shi G, Jones CR, Lipzen A, Pennacchio LA, Xu Y, Hallows WC, McMahon T, Yamazaki M, Pt??ek LJ, Fu YH
eLife5(2016 08)

Highly Efficient Genome Editing via CRISPR/Cas9 to Create Clock Gene Knockout Cells.
Korge S, Grudziecki A, Kramer A
Journal of biological rhythms30(5)389-95(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CRY2 and FBXL3 cooperatively degrade c-MYC preventing the development of cancer.
Title: CRY2 and FBXL3 Cooperatively Degrade c-MYC.

These results demonstrate that CRY2 stability controlled by FBXL3 plays a key role in the regulation of human sleep wake behavior.
Title: A Cryptochrome 2 mutation yields advanced sleep phase in humans.

Data show that CRISPR/Cas9 genome editing generated F-box and leucine-rich repeat protein 3 (Fbxl3) knockout in circadian clock model U2OS cells.
Title: Highly Efficient Genome Editing via CRISPR/Cas9 to Create Clock Gene Knockout Cells.

Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
Title: Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.

Mutation in the Fbxl3 protein reveals distinct roles for CRY1 and CRY2 in the circadian molecular clockwork.
Title: Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation.

The following FBXL3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FBXL3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06084	NM_012158.4 Latest version!	Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu06084	XM_005266336.1 Latest version!	Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu47137	XM_005266337.3 Latest version!	Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu84513	XM_017020538.2 Latest version!	Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu06084	NM_012158.3	Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu47137	XM_005266337.2	Homo sapiens F-box and leucine-rich repeat protein 3 (FBXL3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu84513	XM_017020538.1	Homo sapiens F-box and leucine-rich repeat protein 3 (FBXL3), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu06084	NM_012158.2	Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FBXL3 ( NM_012158.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036290.1 Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), mRNA.

Price & Availability↑

CloneID	OHu06084
Clone ID Related Accession (Same CDS sequence)	NM_012158.3 , NM_012158.4 , NM_012158.2 , XM_005266336.1
Accession Version	NM_012158.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA119701.1 and BC072448.1. On Nov 24, 2018 this sequence version replaced NM_012158.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.189466.1, SRR1660805.241012.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152568, SAMEA2152798 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAACGAG GAGGAAGAGA TAGTGACCGT AATTCATCAG AAGAAGGAAC TGCAGAGAAA 
TCCAAGAAAC TGAGGACTAC AAATGAGCAT TCTCAGACTT GTGATTGGGG TAATCTCCTT 
CAGGACATTA TTCTCCAAGT ATTTAAATAT TTGCCTCTTC TTGACCGGGC TCATGCTTCA 
CAAGTTTGCC GCAACTGGAA CCAGGTATTT CACATGCCTG ACTTGTGGAG ATGTTTTGAA 
TTTGAACTGA ATCAGCCAGC TACATCTTAT TTGAAAGCTA CCCATCCAGA GCTGATCAAA 
CAGATTATTA AAAGACATTC AAACCATCTA CAATATGTCA GCTTCAAGGT GGACAGCAGC 
AAGGAATCAG CTGAAGCAGC TTGTGATATA CTATCGCAAC TTGTGAATTG CTCTTTAAAA 
ACACTTGGAC TTATTTCAAC TGCTCGACCA AGCTTTATGG ATTTACCAAA GTCTCACTTT 
ATCTCTGCAC TGACAGTTGT GTTCGTAAAC TCCAAATCCC TGTCTTCGCT TAAGATAGAT 
GATACTCCAG TAGATGATCC ATCTCTCAAA GTACTAGTGG CCAACAATAG TGATACACTC 
AAGCTGTTGA AAATGAGCAG CTGTCCTCAT GTCTCTCCAG CAGGTATCCT TTGTGTGGCT 
GATCAGTGTC ACGGCTTAAG AGAACTAGCC CTGAACTACC ACTTATTGAG TGATGAGTTG 
TTACTTGCAT TGTCTTCTGA AAAACATGTT CGATTAGAAC ATTTGCGCAT TGATGTAGTC 
AGTGAGAATC CTGGACAGAC ACACTTCCAT ACTATTCAGA AGAGTAGCTG GGATGCTTTC 
ATCAGACATT CACCCAAAGT GAACTTAGTG ATGTATTTTT TTTTATATGA AGAAGAATTT 
GACCCCTTCT TTCGCTATGA AATACCTGCC ACCCATCTGT ACTTTGGGAG ATCAGTAAGC 
AAAGATGTGC TTGGCCGTGT GGGAATGACA TGCCCTAGAC TGGTTGAACT AGTAGTGTGT 
GCAAATGGAT TACGGCCACT TGATGAAGAG TTAATTCGCA TTGCAGAACG TTGCAAAAAT 
TTGTCAGCTA TTGGACTAGG GGAATGTGAA GTCTCATGTA GTGCCTTTGT TGAGTTTGTG 
AAGATGTGTG GTGGCCGCCT ATCTCAATTA TCCATTATGG AAGAAGTACT AATTCCTGAC 
CAAAAGTATA GTTTGGAGCA GATTCACTGG GAAGTGTCCA AGCATCTTGG TAGGGTGTGG 
TTTCCCGACA TGATGCCCAC TTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036290.1
CDS	335..1621
Translation	MKRGGRDSDRNSSEEGTAEKSKKLRTTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW

Target ORF information:

RefSeq Version	NM_012158.3
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012158.3

ORF Insert Sequence:

ATGAAACGAG GAGGAAGAGA TAGTGACCGT AATTCATCAG AAGAAGGAAC TGCAGAGAAA 
TCCAAGAAAC TGAGGACTAC AAATGAGCAT TCTCAGACTT GTGATTGGGG TAATCTCCTT 
CAGGACATTA TTCTCCAAGT ATTTAAATAT TTGCCTCTTC TTGACCGGGC TCATGCTTCA 
CAAGTTTGCC GCAACTGGAA CCAGGTATTT CACATGCCTG ACTTGTGGAG ATGTTTTGAA 
TTTGAACTGA ATCAGCCAGC TACATCTTAT TTGAAAGCTA CCCATCCAGA GCTGATCAAA 
CAGATTATTA AAAGACATTC AAACCATCTA CAATATGTCA GCTTCAAGGT GGACAGCAGC 
AAGGAATCAG CTGAAGCAGC TTGTGATATA CTATCGCAAC TTGTGAATTG CTCTTTAAAA 
ACACTTGGAC TTATTTCAAC TGCTCGACCA AGCTTTATGG ATTTACCAAA GTCTCACTTT 
ATCTCTGCAC TGACAGTTGT GTTCGTAAAC TCCAAATCCC TGTCTTCGCT TAAGATAGAT 
GATACTCCAG TAGATGATCC ATCTCTCAAA GTACTAGTGG CCAACAATAG TGATACACTC 
AAGCTGTTGA AAATGAGCAG CTGTCCTCAT GTCTCTCCAG CAGGTATCCT TTGTGTGGCT 
GATCAGTGTC ACGGCTTAAG AGAACTAGCC CTGAACTACC ACTTATTGAG TGATGAGTTG 
TTACTTGCAT TGTCTTCTGA AAAACATGTT CGATTAGAAC ATTTGCGCAT TGATGTAGTC 
AGTGAGAATC CTGGACAGAC ACACTTCCAT ACTATTCAGA AGAGTAGCTG GGATGCTTTC 
ATCAGACATT CACCCAAAGT GAACTTAGTG ATGTATTTTT TTTTATATGA AGAAGAATTT 
GACCCCTTCT TTCGCTATGA AATACCTGCC ACCCATCTGT ACTTTGGGAG ATCAGTAAGC 
AAAGATGTGC TTGGCCGTGT GGGAATGACA TGCCCTAGAC TGGTTGAACT AGTAGTGTGT 
GCAAATGGAT TACGGCCACT TGATGAAGAG TTAATTCGCA TTGCAGAACG TTGCAAAAAT 
TTGTCAGCTA TTGGACTAGG GGAATGTGAA GTCTCATGTA GTGCCTTTGT TGAGTTTGTG 
AAGATGTGTG GTGGCCGCCT ATCTCAATTA TCCATTATGG AAGAAGTACT AATTCCTGAC 
CAAAAGTATA GTTTGGAGCA GATTCACTGG GAAGTGTCCA AGCATCTTGG TAGGGTGTGG 
TTTCCCGACA TGATGCCCAC TTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXL3 ( NM_012158.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036290.1 Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), mRNA.

Price & Availability↑

CloneID	OHu06084
Clone ID Related Accession (Same CDS sequence)	NM_012158.3 , NM_012158.4 , NM_012158.2 , XM_005266336.1
Accession Version	NM_012158.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC001226.1. On Aug 31, 2019 this sequence version replaced NM_012158.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC072448.1, AL833187.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000355619.10/ ENSP00000347834.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAACGAG GAGGAAGAGA TAGTGACCGT AATTCATCAG AAGAAGGAAC TGCAGAGAAA 
TCCAAGAAAC TGAGGACTAC AAATGAGCAT TCTCAGACTT GTGATTGGGG TAATCTCCTT 
CAGGACATTA TTCTCCAAGT ATTTAAATAT TTGCCTCTTC TTGACCGGGC TCATGCTTCA 
CAAGTTTGCC GCAACTGGAA CCAGGTATTT CACATGCCTG ACTTGTGGAG ATGTTTTGAA 
TTTGAACTGA ATCAGCCAGC TACATCTTAT TTGAAAGCTA CCCATCCAGA GCTGATCAAA 
CAGATTATTA AAAGACATTC AAACCATCTA CAATATGTCA GCTTCAAGGT GGACAGCAGC 
AAGGAATCAG CTGAAGCAGC TTGTGATATA CTATCGCAAC TTGTGAATTG CTCTTTAAAA 
ACACTTGGAC TTATTTCAAC TGCTCGACCA AGCTTTATGG ATTTACCAAA GTCTCACTTT 
ATCTCTGCAC TGACAGTTGT GTTCGTAAAC TCCAAATCCC TGTCTTCGCT TAAGATAGAT 
GATACTCCAG TAGATGATCC ATCTCTCAAA GTACTAGTGG CCAACAATAG TGATACACTC 
AAGCTGTTGA AAATGAGCAG CTGTCCTCAT GTCTCTCCAG CAGGTATCCT TTGTGTGGCT 
GATCAGTGTC ACGGCTTAAG AGAACTAGCC CTGAACTACC ACTTATTGAG TGATGAGTTG 
TTACTTGCAT TGTCTTCTGA AAAACATGTT CGATTAGAAC ATTTGCGCAT TGATGTAGTC 
AGTGAGAATC CTGGACAGAC ACACTTCCAT ACTATTCAGA AGAGTAGCTG GGATGCTTTC 
ATCAGACATT CACCCAAAGT GAACTTAGTG ATGTATTTTT TTTTATATGA AGAAGAATTT 
GACCCCTTCT TTCGCTATGA AATACCTGCC ACCCATCTGT ACTTTGGGAG ATCAGTAAGC 
AAAGATGTGC TTGGCCGTGT GGGAATGACA TGCCCTAGAC TGGTTGAACT AGTAGTGTGT 
GCAAATGGAT TACGGCCACT TGATGAAGAG TTAATTCGCA TTGCAGAACG TTGCAAAAAT 
TTGTCAGCTA TTGGACTAGG GGAATGTGAA GTCTCATGTA GTGCCTTTGT TGAGTTTGTG 
AAGATGTGTG GTGGCCGCCT ATCTCAATTA TCCATTATGG AAGAAGTACT AATTCCTGAC 
CAAAAGTATA GTTTGGAGCA GATTCACTGG GAAGTGTCCA AGCATCTTGG TAGGGTGTGG 
TTTCCCGACA TGATGCCCAC TTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036290.1
CDS	335..1621
Translation	MKRGGRDSDRNSSEEGTAEKSKKLRTTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW

Target ORF information:

RefSeq Version	NM_012158.4
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012158.4

ORF Insert Sequence:

ATGAAACGAG GAGGAAGAGA TAGTGACCGT AATTCATCAG AAGAAGGAAC TGCAGAGAAA 
TCCAAGAAAC TGAGGACTAC AAATGAGCAT TCTCAGACTT GTGATTGGGG TAATCTCCTT 
CAGGACATTA TTCTCCAAGT ATTTAAATAT TTGCCTCTTC TTGACCGGGC TCATGCTTCA 
CAAGTTTGCC GCAACTGGAA CCAGGTATTT CACATGCCTG ACTTGTGGAG ATGTTTTGAA 
TTTGAACTGA ATCAGCCAGC TACATCTTAT TTGAAAGCTA CCCATCCAGA GCTGATCAAA 
CAGATTATTA AAAGACATTC AAACCATCTA CAATATGTCA GCTTCAAGGT GGACAGCAGC 
AAGGAATCAG CTGAAGCAGC TTGTGATATA CTATCGCAAC TTGTGAATTG CTCTTTAAAA 
ACACTTGGAC TTATTTCAAC TGCTCGACCA AGCTTTATGG ATTTACCAAA GTCTCACTTT 
ATCTCTGCAC TGACAGTTGT GTTCGTAAAC TCCAAATCCC TGTCTTCGCT TAAGATAGAT 
GATACTCCAG TAGATGATCC ATCTCTCAAA GTACTAGTGG CCAACAATAG TGATACACTC 
AAGCTGTTGA AAATGAGCAG CTGTCCTCAT GTCTCTCCAG CAGGTATCCT TTGTGTGGCT 
GATCAGTGTC ACGGCTTAAG AGAACTAGCC CTGAACTACC ACTTATTGAG TGATGAGTTG 
TTACTTGCAT TGTCTTCTGA AAAACATGTT CGATTAGAAC ATTTGCGCAT TGATGTAGTC 
AGTGAGAATC CTGGACAGAC ACACTTCCAT ACTATTCAGA AGAGTAGCTG GGATGCTTTC 
ATCAGACATT CACCCAAAGT GAACTTAGTG ATGTATTTTT TTTTATATGA AGAAGAATTT 
GACCCCTTCT TTCGCTATGA AATACCTGCC ACCCATCTGT ACTTTGGGAG ATCAGTAAGC 
AAAGATGTGC TTGGCCGTGT GGGAATGACA TGCCCTAGAC TGGTTGAACT AGTAGTGTGT 
GCAAATGGAT TACGGCCACT TGATGAAGAG TTAATTCGCA TTGCAGAACG TTGCAAAAAT 
TTGTCAGCTA TTGGACTAGG GGAATGTGAA GTCTCATGTA GTGCCTTTGT TGAGTTTGTG 
AAGATGTGTG GTGGCCGCCT ATCTCAATTA TCCATTATGG AAGAAGTACT AATTCCTGAC 
CAAAAGTATA GTTTGGAGCA GATTCACTGG GAAGTGTCCA AGCATCTTGG TAGGGTGTGG 
TTTCCCGACA TGATGCCCAC TTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXL3 ( NM_012158.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036290.1 Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), mRNA.

Price & Availability↑

CloneID	OHu06084
Clone ID Related Accession (Same CDS sequence)	NM_012158.3 , NM_012158.4 , NM_012158.2 , XM_005266336.1
Accession Version	NM_012158.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-27
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA119701.1 and BC072448.1. On Jan 24, 2009 this sequence version replaced NM_012158.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC072448.1, SRR1660807.181072.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152568, SAMEA2152798 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAACGAG GAGGAAGAGA TAGTGACCGT AATTCATCAG AAGAAGGAAC TGCAGAGAAA 
TCCAAGAAAC TGAGGACTAC AAATGAGCAT TCTCAGACTT GTGATTGGGG TAATCTCCTT 
CAGGACATTA TTCTCCAAGT ATTTAAATAT TTGCCTCTTC TTGACCGGGC TCATGCTTCA 
CAAGTTTGCC GCAACTGGAA CCAGGTATTT CACATGCCTG ACTTGTGGAG ATGTTTTGAA 
TTTGAACTGA ATCAGCCAGC TACATCTTAT TTGAAAGCTA CCCATCCAGA GCTGATCAAA 
CAGATTATTA AAAGACATTC AAACCATCTA CAATATGTCA GCTTCAAGGT GGACAGCAGC 
AAGGAATCAG CTGAAGCAGC TTGTGATATA CTATCGCAAC TTGTGAATTG CTCTTTAAAA 
ACACTTGGAC TTATTTCAAC TGCTCGACCA AGCTTTATGG ATTTACCAAA GTCTCACTTT 
ATCTCTGCAC TGACAGTTGT GTTCGTAAAC TCCAAATCCC TGTCTTCGCT TAAGATAGAT 
GATACTCCAG TAGATGATCC ATCTCTCAAA GTACTAGTGG CCAACAATAG TGATACACTC 
AAGCTGTTGA AAATGAGCAG CTGTCCTCAT GTCTCTCCAG CAGGTATCCT TTGTGTGGCT 
GATCAGTGTC ACGGCTTAAG AGAACTAGCC CTGAACTACC ACTTATTGAG TGATGAGTTG 
TTACTTGCAT TGTCTTCTGA AAAACATGTT CGATTAGAAC ATTTGCGCAT TGATGTAGTC 
AGTGAGAATC CTGGACAGAC ACACTTCCAT ACTATTCAGA AGAGTAGCTG GGATGCTTTC 
ATCAGACATT CACCCAAAGT GAACTTAGTG ATGTATTTTT TTTTATATGA AGAAGAATTT 
GACCCCTTCT TTCGCTATGA AATACCTGCC ACCCATCTGT ACTTTGGGAG ATCAGTAAGC 
AAAGATGTGC TTGGCCGTGT GGGAATGACA TGCCCTAGAC TGGTTGAACT AGTAGTGTGT 
GCAAATGGAT TACGGCCACT TGATGAAGAG TTAATTCGCA TTGCAGAACG TTGCAAAAAT 
TTGTCAGCTA TTGGACTAGG GGAATGTGAA GTCTCATGTA GTGCCTTTGT TGAGTTTGTG 
AAGATGTGTG GTGGCCGCCT ATCTCAATTA TCCATTATGG AAGAAGTACT AATTCCTGAC 
CAAAAGTATA GTTTGGAGCA GATTCACTGG GAAGTGTCCA AGCATCTTGG TAGGGTGTGG 
TTTCCCGACA TGATGCCCAC TTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036290.1
CDS	372..1658
Translation	MKRGGRDSDRNSSEEGTAEKSKKLRTTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW

Target ORF information:

RefSeq Version	NM_012158.2
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012158.2

ORF Insert Sequence:

ATGAAACGAG GAGGAAGAGA TAGTGACCGT AATTCATCAG AAGAAGGAAC TGCAGAGAAA 
TCCAAGAAAC TGAGGACTAC AAATGAGCAT TCTCAGACTT GTGATTGGGG TAATCTCCTT 
CAGGACATTA TTCTCCAAGT ATTTAAATAT TTGCCTCTTC TTGACCGGGC TCATGCTTCA 
CAAGTTTGCC GCAACTGGAA CCAGGTATTT CACATGCCTG ACTTGTGGAG ATGTTTTGAA 
TTTGAACTGA ATCAGCCAGC TACATCTTAT TTGAAAGCTA CCCATCCAGA GCTGATCAAA 
CAGATTATTA AAAGACATTC AAACCATCTA CAATATGTCA GCTTCAAGGT GGACAGCAGC 
AAGGAATCAG CTGAAGCAGC TTGTGATATA CTATCGCAAC TTGTGAATTG CTCTTTAAAA 
ACACTTGGAC TTATTTCAAC TGCTCGACCA AGCTTTATGG ATTTACCAAA GTCTCACTTT 
ATCTCTGCAC TGACAGTTGT GTTCGTAAAC TCCAAATCCC TGTCTTCGCT TAAGATAGAT 
GATACTCCAG TAGATGATCC ATCTCTCAAA GTACTAGTGG CCAACAATAG TGATACACTC 
AAGCTGTTGA AAATGAGCAG CTGTCCTCAT GTCTCTCCAG CAGGTATCCT TTGTGTGGCT 
GATCAGTGTC ACGGCTTAAG AGAACTAGCC CTGAACTACC ACTTATTGAG TGATGAGTTG 
TTACTTGCAT TGTCTTCTGA AAAACATGTT CGATTAGAAC ATTTGCGCAT TGATGTAGTC 
AGTGAGAATC CTGGACAGAC ACACTTCCAT ACTATTCAGA AGAGTAGCTG GGATGCTTTC 
ATCAGACATT CACCCAAAGT GAACTTAGTG ATGTATTTTT TTTTATATGA AGAAGAATTT 
GACCCCTTCT TTCGCTATGA AATACCTGCC ACCCATCTGT ACTTTGGGAG ATCAGTAAGC 
AAAGATGTGC TTGGCCGTGT GGGAATGACA TGCCCTAGAC TGGTTGAACT AGTAGTGTGT 
GCAAATGGAT TACGGCCACT TGATGAAGAG TTAATTCGCA TTGCAGAACG TTGCAAAAAT 
TTGTCAGCTA TTGGACTAGG GGAATGTGAA GTCTCATGTA GTGCCTTTGT TGAGTTTGTG 
AAGATGTGTG GTGGCCGCCT ATCTCAATTA TCCATTATGG AAGAAGTACT AATTCCTGAC 
CAAAAGTATA GTTTGGAGCA GATTCACTGG GAAGTGTCCA AGCATCTTGG TAGGGTGTGG 
TTTCCCGACA TGATGCCCAC TTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXL3 ( XM_005266336.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005266393.1 Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), transcript variant X1, mRNA.

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CloneID	OHu06084
Clone ID Related Accession (Same CDS sequence)	NM_012158.3 , NM_012158.4 , NM_012158.2 , XM_005266336.1
Accession Version	XM_005266336.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAACGAG GAGGAAGAGA TAGTGACCGT AATTCATCAG AAGAAGGAAC TGCAGAGAAA 
TCCAAGAAAC TGAGGACTAC AAATGAGCAT TCTCAGACTT GTGATTGGGG TAATCTCCTT 
CAGGACATTA TTCTCCAAGT ATTTAAATAT TTGCCTCTTC TTGACCGGGC TCATGCTTCA 
CAAGTTTGCC GCAACTGGAA CCAGGTATTT CACATGCCTG ACTTGTGGAG ATGTTTTGAA 
TTTGAACTGA ATCAGCCAGC TACATCTTAT TTGAAAGCTA CCCATCCAGA GCTGATCAAA 
CAGATTATTA AAAGACATTC AAACCATCTA CAATATGTCA GCTTCAAGGT GGACAGCAGC 
AAGGAATCAG CTGAAGCAGC TTGTGATATA CTATCGCAAC TTGTGAATTG CTCTTTAAAA 
ACACTTGGAC TTATTTCAAC TGCTCGACCA AGCTTTATGG ATTTACCAAA GTCTCACTTT 
ATCTCTGCAC TGACAGTTGT GTTCGTAAAC TCCAAATCCC TGTCTTCGCT TAAGATAGAT 
GATACTCCAG TAGATGATCC ATCTCTCAAA GTACTAGTGG CCAACAATAG TGATACACTC 
AAGCTGTTGA AAATGAGCAG CTGTCCTCAT GTCTCTCCAG CAGGTATCCT TTGTGTGGCT 
GATCAGTGTC ACGGCTTAAG AGAACTAGCC CTGAACTACC ACTTATTGAG TGATGAGTTG 
TTACTTGCAT TGTCTTCTGA AAAACATGTT CGATTAGAAC ATTTGCGCAT TGATGTAGTC 
AGTGAGAATC CTGGACAGAC ACACTTCCAT ACTATTCAGA AGAGTAGCTG GGATGCTTTC 
ATCAGACATT CACCCAAAGT GAACTTAGTG ATGTATTTTT TTTTATATGA AGAAGAATTT 
GACCCCTTCT TTCGCTATGA AATACCTGCC ACCCATCTGT ACTTTGGGAG ATCAGTAAGC 
AAAGATGTGC TTGGCCGTGT GGGAATGACA TGCCCTAGAC TGGTTGAACT AGTAGTGTGT 
GCAAATGGAT TACGGCCACT TGATGAAGAG TTAATTCGCA TTGCAGAACG TTGCAAAAAT 
TTGTCAGCTA TTGGACTAGG GGAATGTGAA GTCTCATGTA GTGCCTTTGT TGAGTTTGTG 
AAGATGTGTG GTGGCCGCCT ATCTCAATTA TCCATTATGG AAGAAGTACT AATTCCTGAC 
CAAAAGTATA GTTTGGAGCA GATTCACTGG GAAGTGTCCA AGCATCTTGG TAGGGTGTGG 
TTTCCCGACA TGATGCCCAC TTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005266393.1
CDS	155..1441
Translation	MKRGGRDSDRNSSEEGTAEKSKKLRTTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW

Target ORF information:

RefSeq Version	XM_005266336.1
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005266336.1

ORF Insert Sequence:

ATGAAACGAG GAGGAAGAGA TAGTGACCGT AATTCATCAG AAGAAGGAAC TGCAGAGAAA 
TCCAAGAAAC TGAGGACTAC AAATGAGCAT TCTCAGACTT GTGATTGGGG TAATCTCCTT 
CAGGACATTA TTCTCCAAGT ATTTAAATAT TTGCCTCTTC TTGACCGGGC TCATGCTTCA 
CAAGTTTGCC GCAACTGGAA CCAGGTATTT CACATGCCTG ACTTGTGGAG ATGTTTTGAA 
TTTGAACTGA ATCAGCCAGC TACATCTTAT TTGAAAGCTA CCCATCCAGA GCTGATCAAA 
CAGATTATTA AAAGACATTC AAACCATCTA CAATATGTCA GCTTCAAGGT GGACAGCAGC 
AAGGAATCAG CTGAAGCAGC TTGTGATATA CTATCGCAAC TTGTGAATTG CTCTTTAAAA 
ACACTTGGAC TTATTTCAAC TGCTCGACCA AGCTTTATGG ATTTACCAAA GTCTCACTTT 
ATCTCTGCAC TGACAGTTGT GTTCGTAAAC TCCAAATCCC TGTCTTCGCT TAAGATAGAT 
GATACTCCAG TAGATGATCC ATCTCTCAAA GTACTAGTGG CCAACAATAG TGATACACTC 
AAGCTGTTGA AAATGAGCAG CTGTCCTCAT GTCTCTCCAG CAGGTATCCT TTGTGTGGCT 
GATCAGTGTC ACGGCTTAAG AGAACTAGCC CTGAACTACC ACTTATTGAG TGATGAGTTG 
TTACTTGCAT TGTCTTCTGA AAAACATGTT CGATTAGAAC ATTTGCGCAT TGATGTAGTC 
AGTGAGAATC CTGGACAGAC ACACTTCCAT ACTATTCAGA AGAGTAGCTG GGATGCTTTC 
ATCAGACATT CACCCAAAGT GAACTTAGTG ATGTATTTTT TTTTATATGA AGAAGAATTT 
GACCCCTTCT TTCGCTATGA AATACCTGCC ACCCATCTGT ACTTTGGGAG ATCAGTAAGC 
AAAGATGTGC TTGGCCGTGT GGGAATGACA TGCCCTAGAC TGGTTGAACT AGTAGTGTGT 
GCAAATGGAT TACGGCCACT TGATGAAGAG TTAATTCGCA TTGCAGAACG TTGCAAAAAT 
TTGTCAGCTA TTGGACTAGG GGAATGTGAA GTCTCATGTA GTGCCTTTGT TGAGTTTGTG 
AAGATGTGTG GTGGCCGCCT ATCTCAATTA TCCATTATGG AAGAAGTACT AATTCCTGAC 
CAAAAGTATA GTTTGGAGCA GATTCACTGG GAAGTGTCCA AGCATCTTGG TAGGGTGTGG 
TTTCCCGACA TGATGCCCAC TTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXL3 ( XM_005266337.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005266394.1 Homo sapiens F-box and leucine-rich repeat protein 3 (FBXL3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu47137
Clone ID Related Accession (Same CDS sequence)	XM_005266337.2 , XM_005266337.3
Accession Version	XM_005266337.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005266337.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATTTAC CAAAGTCTCA CTTTATCTCT GCACTGACAG TTGTGTTCGT AAACTCCAAA 
TCCCTGTCTT CGCTTAAGAT AGATGATACT CCAGTAGATG ATCCATCTCT CAAAGTACTA 
GTGGCCAACA ATAGTGATAC ACTCAAGCTG TTGAAAATGA GCAGCTGTCC TCATGTCTCT 
CCAGCAGGTA TCCTTTGTGT GGCTGATCAG TGTCACGGCT TAAGAGAACT AGCCCTGAAC 
TACCACTTAT TGAGTGATGA GTTGTTACTT GCATTGTCTT CTGAAAAACA TGTTCGATTA 
GAACATTTGC GCATTGATGT AGTCAGTGAG AATCCTGGAC AGACACACTT CCATACTATT 
CAGAAGAGTA GCTGGGATGC TTTCATCAGA CATTCACCCA AAGTGAACTT AGTGATGTAT 
TTTTTTTTAT ATGAAGAAGA ATTTGACCCC TTCTTTCGCT ATGAAATACC TGCCACCCAT 
CTGTACTTTG GGAGATCAGT AAGCAAAGAT GTGCTTGGCC GTGTGGGAAT GACATGCCCT 
AGACTGGTTG AACTAGTAGT GTGTGCAAAT GGATTACGGC CACTTGATGA AGAGTTAATT 
CGCATTGCAG AACGTTGCAA AAATTTGTCA GCTATTGGAC TAGGGGAATG TGAAGTCTCA 
TGTAGTGCCT TTGTTGAGTT TGTGAAGATG TGTGGTGGCC GCCTATCTCA ATTATCCATT 
ATGGAAGAAG TACTAATTCC TGACCAAAAG TATAGTTTGG AGCAGATTCA CTGGGAAGTG 
TCCAAGCATC TTGGTAGGGT GTGGTTTCCC GACATGATGC CCACTTGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005266394.1
CDS	463..1293
Translation	MDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW

Target ORF information:

RefSeq Version	XM_005266337.2
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine-rich repeat protein 3 (FBXL3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005266337.2

ORF Insert Sequence:

ATGGATTTAC CAAAGTCTCA CTTTATCTCT GCACTGACAG TTGTGTTCGT AAACTCCAAA 
TCCCTGTCTT CGCTTAAGAT AGATGATACT CCAGTAGATG ATCCATCTCT CAAAGTACTA 
GTGGCCAACA ATAGTGATAC ACTCAAGCTG TTGAAAATGA GCAGCTGTCC TCATGTCTCT 
CCAGCAGGTA TCCTTTGTGT GGCTGATCAG TGTCACGGCT TAAGAGAACT AGCCCTGAAC 
TACCACTTAT TGAGTGATGA GTTGTTACTT GCATTGTCTT CTGAAAAACA TGTTCGATTA 
GAACATTTGC GCATTGATGT AGTCAGTGAG AATCCTGGAC AGACACACTT CCATACTATT 
CAGAAGAGTA GCTGGGATGC TTTCATCAGA CATTCACCCA AAGTGAACTT AGTGATGTAT 
TTTTTTTTAT ATGAAGAAGA ATTTGACCCC TTCTTTCGCT ATGAAATACC TGCCACCCAT 
CTGTACTTTG GGAGATCAGT AAGCAAAGAT GTGCTTGGCC GTGTGGGAAT GACATGCCCT 
AGACTGGTTG AACTAGTAGT GTGTGCAAAT GGATTACGGC CACTTGATGA AGAGTTAATT 
CGCATTGCAG AACGTTGCAA AAATTTGTCA GCTATTGGAC TAGGGGAATG TGAAGTCTCA 
TGTAGTGCCT TTGTTGAGTT TGTGAAGATG TGTGGTGGCC GCCTATCTCA ATTATCCATT 
ATGGAAGAAG TACTAATTCC TGACCAAAAG TATAGTTTGG AGCAGATTCA CTGGGAAGTG 
TCCAAGCATC TTGGTAGGGT GTGGTTTCCC GACATGATGC CCACTTGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXL3 ( XM_005266337.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005266394.1 Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu47137
Clone ID Related Accession (Same CDS sequence)	XM_005266337.2 , XM_005266337.3
Accession Version	XM_005266337.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005266337.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATTTAC CAAAGTCTCA CTTTATCTCT GCACTGACAG TTGTGTTCGT AAACTCCAAA 
TCCCTGTCTT CGCTTAAGAT AGATGATACT CCAGTAGATG ATCCATCTCT CAAAGTACTA 
GTGGCCAACA ATAGTGATAC ACTCAAGCTG TTGAAAATGA GCAGCTGTCC TCATGTCTCT 
CCAGCAGGTA TCCTTTGTGT GGCTGATCAG TGTCACGGCT TAAGAGAACT AGCCCTGAAC 
TACCACTTAT TGAGTGATGA GTTGTTACTT GCATTGTCTT CTGAAAAACA TGTTCGATTA 
GAACATTTGC GCATTGATGT AGTCAGTGAG AATCCTGGAC AGACACACTT CCATACTATT 
CAGAAGAGTA GCTGGGATGC TTTCATCAGA CATTCACCCA AAGTGAACTT AGTGATGTAT 
TTTTTTTTAT ATGAAGAAGA ATTTGACCCC TTCTTTCGCT ATGAAATACC TGCCACCCAT 
CTGTACTTTG GGAGATCAGT AAGCAAAGAT GTGCTTGGCC GTGTGGGAAT GACATGCCCT 
AGACTGGTTG AACTAGTAGT GTGTGCAAAT GGATTACGGC CACTTGATGA AGAGTTAATT 
CGCATTGCAG AACGTTGCAA AAATTTGTCA GCTATTGGAC TAGGGGAATG TGAAGTCTCA 
TGTAGTGCCT TTGTTGAGTT TGTGAAGATG TGTGGTGGCC GCCTATCTCA ATTATCCATT 
ATGGAAGAAG TACTAATTCC TGACCAAAAG TATAGTTTGG AGCAGATTCA CTGGGAAGTG 
TCCAAGCATC TTGGTAGGGT GTGGTTTCCC GACATGATGC CCACTTGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005266394.1
CDS	447..1277
Translation	MDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW

Target ORF information:

RefSeq Version	XM_005266337.3
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005266337.3

ORF Insert Sequence:

ATGGATTTAC CAAAGTCTCA CTTTATCTCT GCACTGACAG TTGTGTTCGT AAACTCCAAA 
TCCCTGTCTT CGCTTAAGAT AGATGATACT CCAGTAGATG ATCCATCTCT CAAAGTACTA 
GTGGCCAACA ATAGTGATAC ACTCAAGCTG TTGAAAATGA GCAGCTGTCC TCATGTCTCT 
CCAGCAGGTA TCCTTTGTGT GGCTGATCAG TGTCACGGCT TAAGAGAACT AGCCCTGAAC 
TACCACTTAT TGAGTGATGA GTTGTTACTT GCATTGTCTT CTGAAAAACA TGTTCGATTA 
GAACATTTGC GCATTGATGT AGTCAGTGAG AATCCTGGAC AGACACACTT CCATACTATT 
CAGAAGAGTA GCTGGGATGC TTTCATCAGA CATTCACCCA AAGTGAACTT AGTGATGTAT 
TTTTTTTTAT ATGAAGAAGA ATTTGACCCC TTCTTTCGCT ATGAAATACC TGCCACCCAT 
CTGTACTTTG GGAGATCAGT AAGCAAAGAT GTGCTTGGCC GTGTGGGAAT GACATGCCCT 
AGACTGGTTG AACTAGTAGT GTGTGCAAAT GGATTACGGC CACTTGATGA AGAGTTAATT 
CGCATTGCAG AACGTTGCAA AAATTTGTCA GCTATTGGAC TAGGGGAATG TGAAGTCTCA 
TGTAGTGCCT TTGTTGAGTT TGTGAAGATG TGTGGTGGCC GCCTATCTCA ATTATCCATT 
ATGGAAGAAG TACTAATTCC TGACCAAAAG TATAGTTTGG AGCAGATTCA CTGGGAAGTG 
TCCAAGCATC TTGGTAGGGT GTGGTTTCCC GACATGATGC CCACTTGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXL3 ( XM_017020538.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016876027.1 Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu84513
Clone ID Related Accession (Same CDS sequence)	XM_017020538.2 , XM_017020538.1
Accession Version	XM_017020538.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 753bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 3 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017020538.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAACGAG GAGGAAGAGA TAGTGACCGT AATTCATCAG AAGAAGGAAC TGCAGAGAAA 
TCCAAGAAAC TGAGGACTAC AAATGAGCAT TCTCAGACTT GTGATTGGGG TAATCTCCTT 
CAGGACATTA TTCTCCAAGT ATTTAAATAT TTGCCTCTTC TTGACCGGGC TCATGCTTCA 
CAAGTTTGCC GCAACTGGAA CCAGGTATTT CACATGCCTG ACTTGTGGAG ATGTTTTGAA 
TTTGAACTGA ATCAGCCAGC TACATCTTAT TTGAAAGCTA CCCATCCAGA GCTGATCAAA 
CAGATTATTA AAAGACATTC AAACCATCTA CAATATGTCA GCTTCAAGGT GGACAGCAGC 
AAGGAATCAG CTGAAGCAGC TTGTGATATA CTATCGCAAC TTGTGAATTG CTCTTTAAAA 
ACACTTGGAC TTATTTCAAC TGCTCGACCA AGCTTTATGG ATTTACCAAA GTCTCACTTT 
ATCTCTGCAC TGACAGTTGT GTTCGTAAAC TCCAAATCCC TGTCTTCGCT TAAGATAGAT 
GATACTCCAG TAGATGATCC ATCTCTCAAA GTACTAGTGG CCAACAATAG TGATACACTC 
AAGCTGTTGA AAATGAGCAG CTGTCCTCAT GTCTCTCCAG CAGCTATCTC TGACCGCCGG 
AGGCTGTGTC TTCTCTGTCA AAGGCTGGAA TCGACCTCCC AGGTGTGCGG GCTCTGTCCC 
CGACTTAGGA CCGGCGTCCT ACCTCCAGGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016876027.1
CDS	340..1092
Translation	MKRGGRDSDRNSSEEGTAEKSKKLRTTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAAISDRRRLCLLCQRLESTSQVCGLCPRLRTGVLPPG

Target ORF information:

RefSeq Version	XM_017020538.2
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017020538.2

ORF Insert Sequence:

ATGAAACGAG GAGGAAGAGA TAGTGACCGT AATTCATCAG AAGAAGGAAC TGCAGAGAAA 
TCCAAGAAAC TGAGGACTAC AAATGAGCAT TCTCAGACTT GTGATTGGGG TAATCTCCTT 
CAGGACATTA TTCTCCAAGT ATTTAAATAT TTGCCTCTTC TTGACCGGGC TCATGCTTCA 
CAAGTTTGCC GCAACTGGAA CCAGGTATTT CACATGCCTG ACTTGTGGAG ATGTTTTGAA 
TTTGAACTGA ATCAGCCAGC TACATCTTAT TTGAAAGCTA CCCATCCAGA GCTGATCAAA 
CAGATTATTA AAAGACATTC AAACCATCTA CAATATGTCA GCTTCAAGGT GGACAGCAGC 
AAGGAATCAG CTGAAGCAGC TTGTGATATA CTATCGCAAC TTGTGAATTG CTCTTTAAAA 
ACACTTGGAC TTATTTCAAC TGCTCGACCA AGCTTTATGG ATTTACCAAA GTCTCACTTT 
ATCTCTGCAC TGACAGTTGT GTTCGTAAAC TCCAAATCCC TGTCTTCGCT TAAGATAGAT 
GATACTCCAG TAGATGATCC ATCTCTCAAA GTACTAGTGG CCAACAATAG TGATACACTC 
AAGCTGTTGA AAATGAGCAG CTGTCCTCAT GTCTCTCCAG CAGCTATCTC TGACCGCCGG 
AGGCTGTGTC TTCTCTGTCA AAGGCTGGAA TCGACCTCCC AGGTGTGCGG GCTCTGTCCC 
CGACTTAGGA CCGGCGTCCT ACCTCCAGGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXL3 ( XM_017020538.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016876027.1 Homo sapiens F-box and leucine-rich repeat protein 3 (FBXL3), transcript variant X3, mRNA.

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CloneID	OHu84513
Clone ID Related Accession (Same CDS sequence)	XM_017020538.2 , XM_017020538.1
Accession Version	XM_017020538.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 753bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 3 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAACGAG GAGGAAGAGA TAGTGACCGT AATTCATCAG AAGAAGGAAC TGCAGAGAAA 
TCCAAGAAAC TGAGGACTAC AAATGAGCAT TCTCAGACTT GTGATTGGGG TAATCTCCTT 
CAGGACATTA TTCTCCAAGT ATTTAAATAT TTGCCTCTTC TTGACCGGGC TCATGCTTCA 
CAAGTTTGCC GCAACTGGAA CCAGGTATTT CACATGCCTG ACTTGTGGAG ATGTTTTGAA 
TTTGAACTGA ATCAGCCAGC TACATCTTAT TTGAAAGCTA CCCATCCAGA GCTGATCAAA 
CAGATTATTA AAAGACATTC AAACCATCTA CAATATGTCA GCTTCAAGGT GGACAGCAGC 
AAGGAATCAG CTGAAGCAGC TTGTGATATA CTATCGCAAC TTGTGAATTG CTCTTTAAAA 
ACACTTGGAC TTATTTCAAC TGCTCGACCA AGCTTTATGG ATTTACCAAA GTCTCACTTT 
ATCTCTGCAC TGACAGTTGT GTTCGTAAAC TCCAAATCCC TGTCTTCGCT TAAGATAGAT 
GATACTCCAG TAGATGATCC ATCTCTCAAA GTACTAGTGG CCAACAATAG TGATACACTC 
AAGCTGTTGA AAATGAGCAG CTGTCCTCAT GTCTCTCCAG CAGCTATCTC TGACCGCCGG 
AGGCTGTGTC TTCTCTGTCA AAGGCTGGAA TCGACCTCCC AGGTGTGCGG GCTCTGTCCC 
CGACTTAGGA CCGGCGTCCT ACCTCCAGGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016876027.1
CDS	356..1108
Translation	MKRGGRDSDRNSSEEGTAEKSKKLRTTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAAISDRRRLCLLCQRLESTSQVCGLCPRLRTGVLPPG

Target ORF information:

RefSeq Version	XM_017020538.1
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine-rich repeat protein 3 (FBXL3), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017020538.1

ORF Insert Sequence:

ATGAAACGAG GAGGAAGAGA TAGTGACCGT AATTCATCAG AAGAAGGAAC TGCAGAGAAA 
TCCAAGAAAC TGAGGACTAC AAATGAGCAT TCTCAGACTT GTGATTGGGG TAATCTCCTT 
CAGGACATTA TTCTCCAAGT ATTTAAATAT TTGCCTCTTC TTGACCGGGC TCATGCTTCA 
CAAGTTTGCC GCAACTGGAA CCAGGTATTT CACATGCCTG ACTTGTGGAG ATGTTTTGAA 
TTTGAACTGA ATCAGCCAGC TACATCTTAT TTGAAAGCTA CCCATCCAGA GCTGATCAAA 
CAGATTATTA AAAGACATTC AAACCATCTA CAATATGTCA GCTTCAAGGT GGACAGCAGC 
AAGGAATCAG CTGAAGCAGC TTGTGATATA CTATCGCAAC TTGTGAATTG CTCTTTAAAA 
ACACTTGGAC TTATTTCAAC TGCTCGACCA AGCTTTATGG ATTTACCAAA GTCTCACTTT 
ATCTCTGCAC TGACAGTTGT GTTCGTAAAC TCCAAATCCC TGTCTTCGCT TAAGATAGAT 
GATACTCCAG TAGATGATCC ATCTCTCAAA GTACTAGTGG CCAACAATAG TGATACACTC 
AAGCTGTTGA AAATGAGCAG CTGTCCTCAT GTCTCTCCAG CAGCTATCTC TGACCGCCGG 
AGGCTGTGTC TTCTCTGTCA AAGGCTGGAA TCGACCTCCC AGGTGTGCGG GCTCTGTCCC 
CGACTTAGGA CCGGCGTCCT ACCTCCAGGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-181d and c-myc-mediated inhibition of CRY2 and FBXL3 reprograms metabolism in colorectal cancer.
Cell death & disease8(7)e2958(2017 Jul)
Guo X,Zhu Y,Hong X,Zhang M,Qiu X,Wang Z,Qi Z,Hong X

CRY2 and FBXL3 Cooperatively Degrade c-MYC.
Molecular cell64(4)774-789(2016 Nov)
Huber AL,Papp SJ,Chan AB,Henriksson E,Jordan SD,Kriebs A,Nguyen M,Wallace M,Li Z,Metallo CM,Lamia KA

A Cryptochrome 2 mutation yields advanced sleep phase in humans.
eLife5(2016 08)
Hirano A,Shi G,Jones CR,Lipzen A,Pennacchio LA,Xu Y,Hallows WC,McMahon T,Yamazaki M,Pt??ek LJ,Fu YH

Highly Efficient Genome Editing via CRISPR/Cas9 to Create Clock Gene Knockout Cells.
Journal of biological rhythms30(5)389-95(2015 Oct)
Korge S,Grudziecki A,Kramer A

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FBXL3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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