GAS1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GAS1
Entrez Gene ID	2619
Full Name	growth arrest specific 1
General protein information	Preferred Names growth arrest specific 1 Names growth arrest-specific protein 1 GAS-1 Growth arrest-specific gene-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q21.33
Summary	Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	139185

mRNA and Protein(s)

mRNA	Protein	Name
NM_002048.3	NP_002039.2	growth arrest-specific protein 1 precursor
NM_002048.2	NP_002039.2	growth arrest-specific protein 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GAS1	NP_002039.2
Canis lupus familiaris (dog)	GAS1	XP_849279.1
Bos taurus (cattle)	GAS1	XP_002689867.1
Mus musculus (house mouse)	Gas1	NP_032112.1
Danio rerio (zebrafish)	gas1b	NP_001071269.1
Danio rerio (zebrafish)	gas1a	NP_001104690.1
Xenopus tropicalis (tropical clawed frog)	gas1	NP_001072692.1
Pan troglodytes (chimpanzee)	GAS1	XP_001138712.3
Rattus norvegicus (Norway rat)	Gas1	XP_003751685.1

Gene Ontology
Bibliography

Related articles in PubMed

Downregulation of OCLN and GAS1 in clear cell renal cell carcinoma.
Concei??o AL, Da Silva CT, Badial RM, Valsechi MC, Stuqui B, Gon?alves JD, Jasiulionis MG, De Freitas Calmon M, Rahal P
Oncology reports37(3)1487-1496(2017 Mar)

WT1 is involved in the Akt-JNK pathway dependent autophagy through directly regulating Gas1 expression in human osteosarcoma cells.
Mo H, He J, Yuan Z, Mo L, Wu Z, Lin X, Liu B, Guan J
Biochemical and biophysical research communications478(1)74-80(2016 09)

Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma.
Li Q, Qin Y, Wei P, Lian P, Li Y, Xu Y, Li X, Li D, Cai S
Molecular cancer research : MCR14(9)830-40(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Downregulation of GAS1 is associated with clear cell renal cell carcinoma.
Title: Downregulation of OCLN and GAS1 in clear cell renal cell carcinoma.

These results demonstrated that miR-184 and the GAS1/Akt pathway may be a potential therapeutic target for intervertebral disc degeneration.
Title: MiR-184 Regulates Proliferation in Nucleus Pulposus Cells by Targeting GAS1.

WT1 modulates Akt/JNK signaling pathway mediated autophagy by controlling the expression of growth arrest-specific 1 (Gas1).
Title: WT1 is involved in the Akt-JNK pathway dependent autophagy through directly regulating Gas1 expression in human osteosarcoma cells.

Studies establish Gas1 as a negative regulator in colorectal cancer.
Title: Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma.

the synergistic effect of Gas1 inhibition and GDNF against glutamate-induced cell injury in human SH-SY5Y neuroblastoma cells, is reported.
Title: Gas1 Knockdown Increases the Neuroprotective Effect of Glial Cell-Derived Neurotrophic Factor Against Glutamate-Induced Cell Injury in Human SH-SY5Y Neuroblastoma Cells.

The following GAS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GAS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24962	NM_002048.3 Latest version!	Homo sapiens growth arrest specific 1 (GAS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
View Old Accession Versions >>
OHu24962	NM_002048.2	Homo sapiens growth arrest specific 1 (GAS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GAS1 ( NM_002048.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002039.2 Homo sapiens growth arrest specific 1 (GAS1), mRNA.

Price & Availability↑

CloneID	OHu24962
Clone ID Related Accession (Same CDS sequence)	NM_002048.3 , NM_002048.2
Accession Version	NM_002048.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	growth arrest-specific protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL158149.14, L13698.1, BC132682.1 and BM661942.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002048.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: ERR279833.2917.1, L13698.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000298743.9/ ENSP00000298743.7 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGGCCG CGCTGCTGGG CGGCGGCGGC GAGGCCCGCG GGGGGACAGT GCCGGGCGCC 
TGGCTGTGCC TGATGGCGCT GCTGCAGCTG CTGGGCTCGG CGCCGCGGGG ATCGGGGCTG 
GCGCACGGCC GCCGCCTCAT CTGCTGGCAG GCGCTGCTGC AGTGCCAGGG GGAGCCGGAG 
TGCAGCTACG CCTACAACCA GTACGCCGAG GCGTGCGCGC CGGTGCTGGC GCAGCACGGC 
GGGGGCGACG CGCCCGGGGC CGCCGCCGCC GCTTTCCCGG CCTCGGCCGC CTCTTTCTCG 
TCGCGCTGGC GCTGCCCGAG TCACTGCATC TCGGCCCTCA TTCAGCTCAA CCACACGCGC 
CGCGGGCCCG CCCTGGAGGA CTGTGACTGC GCGCAGGACG AGAACTGCAA GTCCACCAAG 
CGCGCCATTG AGCCGTGCCT GCCCCGGACG AGCGGCGGCG GCGCGGGCGG CCCCGGCGCG 
GGCGGGGTCA TGGGCTGCAC CGAGGCCCGG CGGCGCTGCG ACCGCGACAG CCGCTGCAAC 
CTGGCGCTGA GCCGCTACCT GACCTACTGC GGCAAAGTCT TCAACGGGCT GCGCTGCACG 
GACGAATGCC GCACCGTCAT TGAGGACATG CTGGCTATGC CCAAGGCGGC GCTGCTCAAC 
GACTGCGTGT GCGACGGCCT CGAGCGGCCC ATCTGCGAGT CGGTCAAGGA GAACATGGCC 
CGCCTGTGCT TCGGCGCCGA GCTGGGCAAC GGCCCCGGCA GCAGCGGCTC GGACGGGGGC 
CTGGACGACT ACTACGATGA GGACTACGAT GACGAGCAGC GCACCGGGGG CGCGGGTGGT 
GAGCAGCCGC TGGACGACGA CGACGGCGTC CCGCACCCAC CGCGCCCGGG CAGCGGCGCT 
GCTGCATCGG GCGGCCGCGG GGACCTGCCC TATGGGCCTG GGCGCAGGAG CAGCGGCGGC 
GGCGGCCGCT TGGCGCCCCG GGGCGCCTGG ACCCCACTCG CCTCCATCTT GCTGCTGCTG 
CTTGGGCCGC TCTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002039.2
CDS	728..1765
Translation	MVAALLGGGGEARGGTVPGAWLCLMALLQLLGSAPRGSGLAHGRRLICWQALLQCQGEPECSYAYNQYAEACAPVLAQHGGGDAPGAAAAAFPASAASFSSRWRCPSHCISALIQLNHTRRGPALEDCDCAQDENCKSTKRAIEPCLPRTSGGGAGGPGAGGVMGCTEARRRCDRDSRCNLALSRYLTYCGKVFNGLRCTDECRTVIEDMLAMPKAALLNDCVCDGLERPICESVKENMARLCFGAELGNGPGSSGSDGGLDDYYDEDYDDEQRTGGAGGEQPLDDDDGVPHPPRPGSGAAASGGRGDLPYGPGRRSSGGGGRLAPRGAWTPLASILLLLLGPLF

Target ORF information:

RefSeq Version	NM_002048.3
Organism	Homo sapiens(human)
Definition	Homo sapiens growth arrest specific 1 (GAS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002048.3

ORF Insert Sequence:

ATGGTGGCCG CGCTGCTGGG CGGCGGCGGC GAGGCCCGCG GGGGGACAGT GCCGGGCGCC 
TGGCTGTGCC TGATGGCGCT GCTGCAGCTG CTGGGCTCGG CGCCGCGGGG ATCGGGGCTG 
GCGCACGGCC GCCGCCTCAT CTGCTGGCAG GCGCTGCTGC AGTGCCAGGG GGAGCCGGAG 
TGCAGCTACG CCTACAACCA GTACGCCGAG GCGTGCGCGC CGGTGCTGGC GCAGCACGGC 
GGGGGCGACG CGCCCGGGGC CGCCGCCGCC GCTTTCCCGG CCTCGGCCGC CTCTTTCTCG 
TCGCGCTGGC GCTGCCCGAG TCACTGCATC TCGGCCCTCA TTCAGCTCAA CCACACGCGC 
CGCGGGCCCG CCCTGGAGGA CTGTGACTGC GCGCAGGACG AGAACTGCAA GTCCACCAAG 
CGCGCCATTG AGCCGTGCCT GCCCCGGACG AGCGGCGGCG GCGCGGGCGG CCCCGGCGCG 
GGCGGGGTCA TGGGCTGCAC CGAGGCCCGG CGGCGCTGCG ACCGCGACAG CCGCTGCAAC 
CTGGCGCTGA GCCGCTACCT GACCTACTGC GGCAAAGTCT TCAACGGGCT GCGCTGCACG 
GACGAATGCC GCACCGTCAT TGAGGACATG CTGGCTATGC CCAAGGCGGC GCTGCTCAAC 
GACTGCGTGT GCGACGGCCT CGAGCGGCCC ATCTGCGAGT CGGTCAAGGA GAACATGGCC 
CGCCTGTGCT TCGGCGCCGA GCTGGGCAAC GGCCCCGGCA GCAGCGGCTC GGACGGGGGC 
CTGGACGACT ACTACGATGA GGACTACGAT GACGAGCAGC GCACCGGGGG CGCGGGTGGT 
GAGCAGCCGC TGGACGACGA CGACGGCGTC CCGCACCCAC CGCGCCCGGG CAGCGGCGCT 
GCTGCATCGG GCGGCCGCGG GGACCTGCCC TATGGGCCTG GGCGCAGGAG CAGCGGCGGC 
GGCGGCCGCT TGGCGCCCCG GGGCGCCTGG ACCCCACTCG CCTCCATCTT GCTGCTGCTG 
CTTGGGCCGC TCTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GAS1 ( NM_002048.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002039.2 Homo sapiens growth arrest specific 1 (GAS1), mRNA.

Price & Availability↑

CloneID	OHu24962
Clone ID Related Accession (Same CDS sequence)	NM_002048.3 , NM_002048.2
Accession Version	NM_002048.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	growth arrest-specific protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L13698.1, BC132682.1 and BM661942.1. This sequence is a reference standard in the RefSeqGene project. On Feb 8, 2008 this sequence version replaced NM_002048.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: L13698.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGCCG CGCTGCTGGG CGGCGGCGGC GAGGCCCGCG GGGGGACAGT GCCGGGCGCC 
TGGCTGTGCC TGATGGCGCT GCTGCAGCTG CTGGGCTCGG CGCCGCGGGG ATCGGGGCTG 
GCGCACGGCC GCCGCCTCAT CTGCTGGCAG GCGCTGCTGC AGTGCCAGGG GGAGCCGGAG 
TGCAGCTACG CCTACAACCA GTACGCCGAG GCGTGCGCGC CGGTGCTGGC GCAGCACGGC 
GGGGGCGACG CGCCCGGGGC CGCCGCCGCC GCTTTCCCGG CCTCGGCCGC CTCTTTCTCG 
TCGCGCTGGC GCTGCCCGAG TCACTGCATC TCGGCCCTCA TTCAGCTCAA CCACACGCGC 
CGCGGGCCCG CCCTGGAGGA CTGTGACTGC GCGCAGGACG AGAACTGCAA GTCCACCAAG 
CGCGCCATTG AGCCGTGCCT GCCCCGGACG AGCGGCGGCG GCGCGGGCGG CCCCGGCGCG 
GGCGGGGTCA TGGGCTGCAC CGAGGCCCGG CGGCGCTGCG ACCGCGACAG CCGCTGCAAC 
CTGGCGCTGA GCCGCTACCT GACCTACTGC GGCAAAGTCT TCAACGGGCT GCGCTGCACG 
GACGAATGCC GCACCGTCAT TGAGGACATG CTGGCTATGC CCAAGGCGGC GCTGCTCAAC 
GACTGCGTGT GCGACGGCCT CGAGCGGCCC ATCTGCGAGT CGGTCAAGGA GAACATGGCC 
CGCCTGTGCT TCGGCGCCGA GCTGGGCAAC GGCCCCGGCA GCAGCGGCTC GGACGGGGGC 
CTGGACGACT ACTACGATGA GGACTACGAT GACGAGCAGC GCACCGGGGG CGCGGGTGGT 
GAGCAGCCGC TGGACGACGA CGACGGCGTC CCGCACCCAC CGCGCCCGGG CAGCGGCGCT 
GCTGCATCGG GCGGCCGCGG GGACCTGCCC TATGGGCCTG GGCGCAGGAG CAGCGGCGGC 
GGCGGCCGCT TGGCGCCCCG GGGCGCCTGG ACCCCACTCG CCTCCATCTT GCTGCTGCTG 
CTTGGGCCGC TCTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002039.2
CDS	411..1448
Translation	MVAALLGGGGEARGGTVPGAWLCLMALLQLLGSAPRGSGLAHGRRLICWQALLQCQGEPECSYAYNQYAEACAPVLAQHGGGDAPGAAAAAFPASAASFSSRWRCPSHCISALIQLNHTRRGPALEDCDCAQDENCKSTKRAIEPCLPRTSGGGAGGPGAGGVMGCTEARRRCDRDSRCNLALSRYLTYCGKVFNGLRCTDECRTVIEDMLAMPKAALLNDCVCDGLERPICESVKENMARLCFGAELGNGPGSSGSDGGLDDYYDEDYDDEQRTGGAGGEQPLDDDDGVPHPPRPGSGAAASGGRGDLPYGPGRRSSGGGGRLAPRGAWTPLASILLLLLGPLF

Target ORF information:

RefSeq Version	NM_002048.2
Organism	Homo sapiens(human)
Definition	Homo sapiens growth arrest specific 1 (GAS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002048.2

ORF Insert Sequence:

ATGGTGGCCG CGCTGCTGGG CGGCGGCGGC GAGGCCCGCG GGGGGACAGT GCCGGGCGCC 
TGGCTGTGCC TGATGGCGCT GCTGCAGCTG CTGGGCTCGG CGCCGCGGGG ATCGGGGCTG 
GCGCACGGCC GCCGCCTCAT CTGCTGGCAG GCGCTGCTGC AGTGCCAGGG GGAGCCGGAG 
TGCAGCTACG CCTACAACCA GTACGCCGAG GCGTGCGCGC CGGTGCTGGC GCAGCACGGC 
GGGGGCGACG CGCCCGGGGC CGCCGCCGCC GCTTTCCCGG CCTCGGCCGC CTCTTTCTCG 
TCGCGCTGGC GCTGCCCGAG TCACTGCATC TCGGCCCTCA TTCAGCTCAA CCACACGCGC 
CGCGGGCCCG CCCTGGAGGA CTGTGACTGC GCGCAGGACG AGAACTGCAA GTCCACCAAG 
CGCGCCATTG AGCCGTGCCT GCCCCGGACG AGCGGCGGCG GCGCGGGCGG CCCCGGCGCG 
GGCGGGGTCA TGGGCTGCAC CGAGGCCCGG CGGCGCTGCG ACCGCGACAG CCGCTGCAAC 
CTGGCGCTGA GCCGCTACCT GACCTACTGC GGCAAAGTCT TCAACGGGCT GCGCTGCACG 
GACGAATGCC GCACCGTCAT TGAGGACATG CTGGCTATGC CCAAGGCGGC GCTGCTCAAC 
GACTGCGTGT GCGACGGCCT CGAGCGGCCC ATCTGCGAGT CGGTCAAGGA GAACATGGCC 
CGCCTGTGCT TCGGCGCCGA GCTGGGCAAC GGCCCCGGCA GCAGCGGCTC GGACGGGGGC 
CTGGACGACT ACTACGATGA GGACTACGAT GACGAGCAGC GCACCGGGGG CGCGGGTGGT 
GAGCAGCCGC TGGACGACGA CGACGGCGTC CCGCACCCAC CGCGCCCGGG CAGCGGCGCT 
GCTGCATCGG GCGGCCGCGG GGACCTGCCC TATGGGCCTG GGCGCAGGAG CAGCGGCGGC 
GGCGGCCGCT TGGCGCCCCG GGGCGCCTGG ACCCCACTCG CCTCCATCTT GCTGCTGCTG 
CTTGGGCCGC TCTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Downregulation of OCLN and GAS1 in clear cell renal cell carcinoma.
Oncology reports37(3)1487-1496(2017 Mar)
Concei??o AL,Da Silva CT,Badial RM,Valsechi MC,Stuqui B,Gon?alves JD,Jasiulionis MG,De Freitas Calmon M,Rahal P

WT1 is involved in the Akt-JNK pathway dependent autophagy through directly regulating Gas1 expression in human osteosarcoma cells.
Biochemical and biophysical research communications478(1)74-80(2016 09)
Mo H,He J,Yuan Z,Mo L,Wu Z,Lin X,Liu B,Guan J

Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma.
Molecular cancer research : MCR14(9)830-40(2016 Sep)
Li Q,Qin Y,Wei P,Lian P,Li Y,Xu Y,Li X,Li D,Cai S

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GAS1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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