PTCD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PTCD1
Entrez Gene ID	26024
Full Name	pentatricopeptide repeat domain 1
General protein information	Preferred Names pentatricopeptide repeat domain 1 Names pentatricopeptide repeat-containing protein 1, mitochondrial
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q22.1
Summary	This gene encodes a mitochondrial protein that binds leucine tRNAs and other mitochondrial RNAs and plays a role in the regulation of translation. Increased expression of this gene results in decreased mitochondrial leucine tRNA levels. Naturally occurring read-through transcription exists between upstream ATP5J2 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2) and this gene. [provided by RefSeq, Aug 2015].
Disorder MIM:	614774

mRNA and Protein(s)

mRNA	Protein	Name
NM_015545.3	NP_056360.2	pentatricopeptide repeat-containing protein 1, mitochondrial
NM_015545.4	NP_056360.2	pentatricopeptide repeat-containing protein 1, mitochondrial

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Mitochondrial leucine tRNA level and PTCD1 are regulated in response to leucine starvation.
Schild C, Hahn D, Schaller A, Jackson CB, Rothen-Rutishauser B, Mirkovitch J, Nuoffer JM
Amino acids46(7)1775-83(2014 Jul)

Human pentatricopeptide proteins: only a few and what do they do?
Lightowlers RN, Chrzanowska-Lightowlers ZM
RNA biology10(9)1433-8(2013)

The role of mammalian PPR domain proteins in the regulation of mitochondrial gene expression.
Rackham O, Filipovska A
Biochimica et biophysica acta1819(9-10)1008-16(2012 Sep-Oct)

RNA processing in human mitochondria.
Sanchez MI, Mercer TR, Davies SM, Shearwood AM, Nyg?rd KK, Richman TR, Mattick JS, Rackham O, Filipovska A
Cell cycle (Georgetown, Tex.)10(17)2904-16(2011 Sep)

Pentatricopeptide repeat domain protein 1 lowers the levels of mitochondrial leucine tRNAs in cells.
Rackham O, Davies SM, Shearwood AM, Hamilton KL, Whelan J, Filipovska A
Nucleic acids research37(17)5859-67(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Leucine starvation decreased PTCD1 on the protein level.
Title: Mitochondrial leucine tRNA level and PTCD1 are regulated in response to leucine starvation.

ELAC2 and PTCD1 affect the 3' end processing of tRNAs.
Title: RNA processing in human mitochondria.

The following PTCD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTCD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09305	NM_015545.4 Latest version!	Homo sapiens pentatricopeptide repeat domain 1 (PTCD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu09305	NM_015545.3	Homo sapiens pentatricopeptide repeat domain 1 (PTCD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PTCD1 ( NM_015545.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_056360.2 Homo sapiens pentatricopeptide repeat domain 1 (PTCD1), mRNA.

Price & Availability↑

CloneID	OHu09305
Clone ID Related Accession (Same CDS sequence)	NM_015545.3 , NM_015545.4
Accession Version	NM_015545.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2103bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	pentatricopeptide repeat-containing protein 1, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA770648.1 and AB014532.1. This sequence is a reference standard in the RefSeqGene project. On Nov 11, 2010 this sequence version replaced NM_015545.2. ##Evidence-Data-START## Transcript exon combination :: AB014532.1, SRR1660805.92789.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 19651879 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACTTCG TGAGACTCGC TCGACTGTTC GCCAGGGCCC GCCCCATGGG ACTGTTCATC 
CTGCAACACC TGGACCCCTG TAGAGCCAGG TGGGCAGGAG GCAGGGAGGG GCTGATGCGG 
CCAATGTGGG CGCCCTTCAG CAGCTCCTCC TCTCAGCTGC CCCTCGGCCA GGAGCGTCAG 
GAAAACACGG GCAGCCTGGG CTCTGACCCG AGCCACTCCA ACTCCACGGC CACGCAGGAA 
GAAGACGAGG AGGAGGAGGA GAGTTTTGGG ACCCTCTCTG ACAAATACTC CTCCCGGAGA 
CTATTCCGCA AATCCGCAGC CCAGTTCCAT AACCTGCGGT TTGGGGAACG GAGAGATGAG 
CAAATGGAAC CGGAGCCCAA ATTATGGCGA GGCCGGAGAA ACACCCCGTA CTGGTACTTC 
TTGCAGTGCA AACACCTGAT CAAGGAAGGG AAGCTGGTTG AAGCCCTGGA CCTGTTTGAG 
AGGCAGATGC TGAAGGAGGA GCGATTGCAG CCCATGGAGA GCAACTACAC GGTGCTGATT 
GGGGGCTGCG GGCGGGTTGG CTACCTGAAG AAGGCCTTCA ACCTCTACAA CCAGATGAAA 
AAGCGGGACC TGGAGCCCTC GGACGCCACC TACACGGCCC TGTTCAACGT CTGTGCCGAG 
TCCCCCTGGA AGGACTCAGC TCTACAGAGC GCCCTGAAGC TCCGGCAGCA GCTGCAGGCC 
AAAAACTTCG AGCTCAACTT GAAAACATAC CACGCGCTGC TGAAGATGGC TGCCAAGTGC 
GCAGACCTTA GGATGTGCCT CGATGTGTTC AAGGAAATCA TCCACAAAGG GCACGTGGTC 
ACAGAGGAGA CCTTCAGTTT CCTGCTCATG GGCTGCATCC AAGACAAGAA GACAGGCTTC 
CGGTACGCCC TCCAGGTGTG GCGGCTGATG CTGAGTCTAG GGCTACAGCC GAGCCGGGAC 
AGCTACAACC TGCTGTTGGT GGCAGCTCGG GACTGTGGCC TAGGGGACCC CCAGGTGGCC 
TCAGAGCTGC TTCTGAAGCC CAGGGAGGAG GCGACTGTGC TTCAGCCCCC AGTGAGCAGG 
CAGCGGCCAA GGAGGACAGC CCAGGCCAAG GCAGGCAACC TCATGTCAGC CATGCTGCAT 
GTGGAGGCCC TGGAGAGGCA GCTGTTTCTG GAACCTTCTC AGGCACTTGG GCCTCCAGAG 
CCTCCGGAAG CCAGAGTGCC CGGCAAGGCC CAACCAGAGG TGGATACTAA GGCAGAGCCC 
AGCCACACAG CAGCCCTCAC CGCAGTGGCC CTGAAGCCAC CTCCCGTGGA GCTGGAAGTC 
AACCTCCTGA CCCCCGGGGC CGTTCCCCCT ACAGTGGTCT CCTTTGGAAC GGTGACCACC 
CCAGCTGACC GGCTGGCCTT GATAGGGGGC CTGGAGGGCT TCCTGAGCAA GATGGCAGAG 
CACAGGCAGC AGCCCGACAT CAGGACCCTC ACGCTACTGG CCGAGGTGGT GGAGTCCGGG 
AGTCCTGCAG AGTCCTTGCT GCTGGCCCTC CTGGATGAGC ACCAGGTAGA GGCCGACCTG 
ACATTCTTTA ACACGCTGGT GAGAAAGAAG AGCAAGCTGG GAGACCTGGA GGGGGCCAAG 
GCGCTGTTGC CGGTCCTGGC AAAGAGGGGC CTCGTCCCCA ACCTGCAGAC ATTCTGCAAC 
CTGGCCATCG GGTGCCACAG GCCGAAGGAC GGTCTACAGC TTCTCACAGA CATGAAGAAG 
TCCCAGGTGA CCCCCAACAC TCACATCTAC AGTGCCCTCA TCAACGCGGC CATCAGGAAG 
CTGAACTACA CCTATCTCAT CAGCATCTTG AAGGACATGA AGCAGAACAG GGTCCCGGTG 
AACGAAGTGG TCATCCGCCA GCTGGAGTTT GCAGCCCAGT ACCCTCCCAC CTTTGACCGG 
TACCAAGGGA AGAACACCTA CCTGGAGAAG ATTGACGGCT TCCGAGCCTA TTACAAGCAG 
TGGCTGACAG TGATGCCCGC AGAGGAAACC CCGCACCCCT GGCAGAAGTT CCGGACCAAG 
CCCCAGGGGG ACCAGGACAC CGGCAAGGAG GCTGATGACG GATGTGCCCT TGGGGGCAGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056360.2
CDS	175..2277
Translation	MDFVRLARLFARARPMGLFILQHLDPCRARWAGGREGLMRPMWAPFSSSSSQLPLGQERQENTGSLGSDPSHSNSTATQEEDEEEEESFGTLSDKYSSRRLFRKSAAQFHNLRFGERRDEQMEPEPKLWRGRRNTPYWYFLQCKHLIKEGKLVEALDLFERQMLKEERLQPMESNYTVLIGGCGRVGYLKKAFNLYNQMKKRDLEPSDATYTALFNVCAESPWKDSALQSALKLRQQLQAKNFELNLKTYHALLKMAAKCADLRMCLDVFKEIIHKGHVVTEETFSFLLMGCIQDKKTGFRYALQVWRLMLSLGLQPSRDSYNLLLVAARDCGLGDPQVASELLLKPREEATVLQPPVSRQRPRRTAQAKAGNLMSAMLHVEALERQLFLEPSQALGPPEPPEARVPGKAQPEVDTKAEPSHTAALTAVALKPPPVELEVNLLTPGAVPPTVVSFGTVTTPADRLALIGGLEGFLSKMAEHRQQPDIRTLTLLAEVVESGSPAESLLLALLDEHQVEADLTFFNTLVRKKSKLGDLEGAKALLPVLAKRGLVPNLQTFCNLAIGCHRPKDGLQLLTDMKKSQVTPNTHIYSALINAAIRKLNYTYLISILKDMKQNRVPVNEVVIRQLEFAAQYPPTFDRYQGKNTYLEKIDGFRAYYKQWLTVMPAEETPHPWQKFRTKPQGDQDTGKEADDGCALGGR

Target ORF information:

RefSeq Version	NM_015545.3
Organism	Homo sapiens(human)
Definition	Homo sapiens pentatricopeptide repeat domain 1 (PTCD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015545.3

ORF Insert Sequence:

ATGGACTTCG TGAGACTCGC TCGACTGTTC GCCAGGGCCC GCCCCATGGG ACTGTTCATC 
CTGCAACACC TGGACCCCTG TAGAGCCAGG TGGGCAGGAG GCAGGGAGGG GCTGATGCGG 
CCAATGTGGG CGCCCTTCAG CAGCTCCTCC TCTCAGCTGC CCCTCGGCCA GGAGCGTCAG 
GAAAACACGG GCAGCCTGGG CTCTGACCCG AGCCACTCCA ACTCCACGGC CACGCAGGAA 
GAAGACGAGG AGGAGGAGGA GAGTTTTGGG ACCCTCTCTG ACAAATACTC CTCCCGGAGA 
CTATTCCGCA AATCCGCAGC CCAGTTCCAT AACCTGCGGT TTGGGGAACG GAGAGATGAG 
CAAATGGAAC CGGAGCCCAA ATTATGGCGA GGCCGGAGAA ACACCCCGTA CTGGTACTTC 
TTGCAGTGCA AACACCTGAT CAAGGAAGGG AAGCTGGTTG AAGCCCTGGA CCTGTTTGAG 
AGGCAGATGC TGAAGGAGGA GCGATTGCAG CCCATGGAGA GCAACTACAC GGTGCTGATT 
GGGGGCTGCG GGCGGGTTGG CTACCTGAAG AAGGCCTTCA ACCTCTACAA CCAGATGAAA 
AAGCGGGACC TGGAGCCCTC GGACGCCACC TACACGGCCC TGTTCAACGT CTGTGCCGAG 
TCCCCCTGGA AGGACTCAGC TCTACAGAGC GCCCTGAAGC TCCGGCAGCA GCTGCAGGCC 
AAAAACTTCG AGCTCAACTT GAAAACATAC CACGCGCTGC TGAAGATGGC TGCCAAGTGC 
GCAGACCTTA GGATGTGCCT CGATGTGTTC AAGGAAATCA TCCACAAAGG GCACGTGGTC 
ACAGAGGAGA CCTTCAGTTT CCTGCTCATG GGCTGCATCC AAGACAAGAA GACAGGCTTC 
CGGTACGCCC TCCAGGTGTG GCGGCTGATG CTGAGTCTAG GGCTACAGCC GAGCCGGGAC 
AGCTACAACC TGCTGTTGGT GGCAGCTCGG GACTGTGGCC TAGGGGACCC CCAGGTGGCC 
TCAGAGCTGC TTCTGAAGCC CAGGGAGGAG GCGACTGTGC TTCAGCCCCC AGTGAGCAGG 
CAGCGGCCAA GGAGGACAGC CCAGGCCAAG GCAGGCAACC TCATGTCAGC CATGCTGCAT 
GTGGAGGCCC TGGAGAGGCA GCTGTTTCTG GAACCTTCTC AGGCACTTGG GCCTCCAGAG 
CCTCCGGAAG CCAGAGTGCC CGGCAAGGCC CAACCAGAGG TGGATACTAA GGCAGAGCCC 
AGCCACACAG CAGCCCTCAC CGCAGTGGCC CTGAAGCCAC CTCCCGTGGA GCTGGAAGTC 
AACCTCCTGA CCCCCGGGGC CGTTCCCCCT ACAGTGGTCT CCTTTGGAAC GGTGACCACC 
CCAGCTGACC GGCTGGCCTT GATAGGGGGC CTGGAGGGCT TCCTGAGCAA GATGGCAGAG 
CACAGGCAGC AGCCCGACAT CAGGACCCTC ACGCTACTGG CCGAGGTGGT GGAGTCCGGG 
AGTCCTGCAG AGTCCTTGCT GCTGGCCCTC CTGGATGAGC ACCAGGTAGA GGCCGACCTG 
ACATTCTTTA ACACGCTGGT GAGAAAGAAG AGCAAGCTGG GAGACCTGGA GGGGGCCAAG 
GCGCTGTTGC CGGTCCTGGC AAAGAGGGGC CTCGTCCCCA ACCTGCAGAC ATTCTGCAAC 
CTGGCCATCG GGTGCCACAG GCCGAAGGAC GGTCTACAGC TTCTCACAGA CATGAAGAAG 
TCCCAGGTGA CCCCCAACAC TCACATCTAC AGTGCCCTCA TCAACGCGGC CATCAGGAAG 
CTGAACTACA CCTATCTCAT CAGCATCTTG AAGGACATGA AGCAGAACAG GGTCCCGGTG 
AACGAAGTGG TCATCCGCCA GCTGGAGTTT GCAGCCCAGT ACCCTCCCAC CTTTGACCGG 
TACCAAGGGA AGAACACCTA CCTGGAGAAG ATTGACGGCT TCCGAGCCTA TTACAAGCAG 
TGGCTGACAG TGATGCCCGC AGAGGAAACC CCGCACCCCT GGCAGAAGTT CCGGACCAAG 
CCCCAGGGGG ACCAGGACAC CGGCAAGGAG GCTGATGACG GATGTGCCCT TGGGGGCAGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTCD1 ( NM_015545.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_056360.2 Homo sapiens pentatricopeptide repeat domain 1 (PTCD1), mRNA.

Price & Availability↑

CloneID	OHu09305
Clone ID Related Accession (Same CDS sequence)	NM_015545.3 , NM_015545.4
Accession Version	NM_015545.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2103bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	pentatricopeptide repeat-containing protein 1, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA770648.1 and AB014532.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_015545.3. ##Evidence-Data-START## Transcript exon combination :: AB014532.1, SRR1803611.45229.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 19651879 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACTTCG TGAGACTCGC TCGACTGTTC GCCAGGGCCC GCCCCATGGG ACTGTTCATC 
CTGCAACACC TGGACCCCTG TAGAGCCAGG TGGGCAGGAG GCAGGGAGGG GCTGATGCGG 
CCAATGTGGG CGCCCTTCAG CAGCTCCTCC TCTCAGCTGC CCCTCGGCCA GGAGCGTCAG 
GAAAACACGG GCAGCCTGGG CTCTGACCCG AGCCACTCCA ACTCCACGGC CACGCAGGAA 
GAAGACGAGG AGGAGGAGGA GAGTTTTGGG ACCCTCTCTG ACAAATACTC CTCCCGGAGA 
CTATTCCGCA AATCCGCAGC CCAGTTCCAT AACCTGCGGT TTGGGGAACG GAGAGATGAG 
CAAATGGAAC CGGAGCCCAA ATTATGGCGA GGCCGGAGAA ACACCCCGTA CTGGTACTTC 
TTGCAGTGCA AACACCTGAT CAAGGAAGGG AAGCTGGTTG AAGCCCTGGA CCTGTTTGAG 
AGGCAGATGC TGAAGGAGGA GCGATTGCAG CCCATGGAGA GCAACTACAC GGTGCTGATT 
GGGGGCTGCG GGCGGGTTGG CTACCTGAAG AAGGCCTTCA ACCTCTACAA CCAGATGAAA 
AAGCGGGACC TGGAGCCCTC GGACGCCACC TACACGGCCC TGTTCAACGT CTGTGCCGAG 
TCCCCCTGGA AGGACTCAGC TCTACAGAGC GCCCTGAAGC TCCGGCAGCA GCTGCAGGCC 
AAAAACTTCG AGCTCAACTT GAAAACATAC CACGCGCTGC TGAAGATGGC TGCCAAGTGC 
GCAGACCTTA GGATGTGCCT CGATGTGTTC AAGGAAATCA TCCACAAAGG GCACGTGGTC 
ACAGAGGAGA CCTTCAGTTT CCTGCTCATG GGCTGCATCC AAGACAAGAA GACAGGCTTC 
CGGTACGCCC TCCAGGTGTG GCGGCTGATG CTGAGTCTAG GGCTACAGCC GAGCCGGGAC 
AGCTACAACC TGCTGTTGGT GGCAGCTCGG GACTGTGGCC TAGGGGACCC CCAGGTGGCC 
TCAGAGCTGC TTCTGAAGCC CAGGGAGGAG GCGACTGTGC TTCAGCCCCC AGTGAGCAGG 
CAGCGGCCAA GGAGGACAGC CCAGGCCAAG GCAGGCAACC TCATGTCAGC CATGCTGCAT 
GTGGAGGCCC TGGAGAGGCA GCTGTTTCTG GAACCTTCTC AGGCACTTGG GCCTCCAGAG 
CCTCCGGAAG CCAGAGTGCC CGGCAAGGCC CAACCAGAGG TGGATACTAA GGCAGAGCCC 
AGCCACACAG CAGCCCTCAC CGCAGTGGCC CTGAAGCCAC CTCCCGTGGA GCTGGAAGTC 
AACCTCCTGA CCCCCGGGGC CGTTCCCCCT ACAGTGGTCT CCTTTGGAAC GGTGACCACC 
CCAGCTGACC GGCTGGCCTT GATAGGGGGC CTGGAGGGCT TCCTGAGCAA GATGGCAGAG 
CACAGGCAGC AGCCCGACAT CAGGACCCTC ACGCTACTGG CCGAGGTGGT GGAGTCCGGG 
AGTCCTGCAG AGTCCTTGCT GCTGGCCCTC CTGGATGAGC ACCAGGTAGA GGCCGACCTG 
ACATTCTTTA ACACGCTGGT GAGAAAGAAG AGCAAGCTGG GAGACCTGGA GGGGGCCAAG 
GCGCTGTTGC CGGTCCTGGC AAAGAGGGGC CTCGTCCCCA ACCTGCAGAC ATTCTGCAAC 
CTGGCCATCG GGTGCCACAG GCCGAAGGAC GGTCTACAGC TTCTCACAGA CATGAAGAAG 
TCCCAGGTGA CCCCCAACAC TCACATCTAC AGTGCCCTCA TCAACGCGGC CATCAGGAAG 
CTGAACTACA CCTATCTCAT CAGCATCTTG AAGGACATGA AGCAGAACAG GGTCCCGGTG 
AACGAAGTGG TCATCCGCCA GCTGGAGTTT GCAGCCCAGT ACCCTCCCAC CTTTGACCGG 
TACCAAGGGA AGAACACCTA CCTGGAGAAG ATTGACGGCT TCCGAGCCTA TTACAAGCAG 
TGGCTGACAG TGATGCCCGC AGAGGAAACC CCGCACCCCT GGCAGAAGTT CCGGACCAAG 
CCCCAGGGGG ACCAGGACAC CGGCAAGGAG GCTGATGACG GATGTGCCCT TGGGGGCAGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056360.2
CDS	134..2236
Translation	MDFVRLARLFARARPMGLFILQHLDPCRARWAGGREGLMRPMWAPFSSSSSQLPLGQERQENTGSLGSDPSHSNSTATQEEDEEEEESFGTLSDKYSSRRLFRKSAAQFHNLRFGERRDEQMEPEPKLWRGRRNTPYWYFLQCKHLIKEGKLVEALDLFERQMLKEERLQPMESNYTVLIGGCGRVGYLKKAFNLYNQMKKRDLEPSDATYTALFNVCAESPWKDSALQSALKLRQQLQAKNFELNLKTYHALLKMAAKCADLRMCLDVFKEIIHKGHVVTEETFSFLLMGCIQDKKTGFRYALQVWRLMLSLGLQPSRDSYNLLLVAARDCGLGDPQVASELLLKPREEATVLQPPVSRQRPRRTAQAKAGNLMSAMLHVEALERQLFLEPSQALGPPEPPEARVPGKAQPEVDTKAEPSHTAALTAVALKPPPVELEVNLLTPGAVPPTVVSFGTVTTPADRLALIGGLEGFLSKMAEHRQQPDIRTLTLLAEVVESGSPAESLLLALLDEHQVEADLTFFNTLVRKKSKLGDLEGAKALLPVLAKRGLVPNLQTFCNLAIGCHRPKDGLQLLTDMKKSQVTPNTHIYSALINAAIRKLNYTYLISILKDMKQNRVPVNEVVIRQLEFAAQYPPTFDRYQGKNTYLEKIDGFRAYYKQWLTVMPAEETPHPWQKFRTKPQGDQDTGKEADDGCALGGR

Target ORF information:

RefSeq Version	NM_015545.4
Organism	Homo sapiens(human)
Definition	Homo sapiens pentatricopeptide repeat domain 1 (PTCD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015545.4

ORF Insert Sequence:

ATGGACTTCG TGAGACTCGC TCGACTGTTC GCCAGGGCCC GCCCCATGGG ACTGTTCATC 
CTGCAACACC TGGACCCCTG TAGAGCCAGG TGGGCAGGAG GCAGGGAGGG GCTGATGCGG 
CCAATGTGGG CGCCCTTCAG CAGCTCCTCC TCTCAGCTGC CCCTCGGCCA GGAGCGTCAG 
GAAAACACGG GCAGCCTGGG CTCTGACCCG AGCCACTCCA ACTCCACGGC CACGCAGGAA 
GAAGACGAGG AGGAGGAGGA GAGTTTTGGG ACCCTCTCTG ACAAATACTC CTCCCGGAGA 
CTATTCCGCA AATCCGCAGC CCAGTTCCAT AACCTGCGGT TTGGGGAACG GAGAGATGAG 
CAAATGGAAC CGGAGCCCAA ATTATGGCGA GGCCGGAGAA ACACCCCGTA CTGGTACTTC 
TTGCAGTGCA AACACCTGAT CAAGGAAGGG AAGCTGGTTG AAGCCCTGGA CCTGTTTGAG 
AGGCAGATGC TGAAGGAGGA GCGATTGCAG CCCATGGAGA GCAACTACAC GGTGCTGATT 
GGGGGCTGCG GGCGGGTTGG CTACCTGAAG AAGGCCTTCA ACCTCTACAA CCAGATGAAA 
AAGCGGGACC TGGAGCCCTC GGACGCCACC TACACGGCCC TGTTCAACGT CTGTGCCGAG 
TCCCCCTGGA AGGACTCAGC TCTACAGAGC GCCCTGAAGC TCCGGCAGCA GCTGCAGGCC 
AAAAACTTCG AGCTCAACTT GAAAACATAC CACGCGCTGC TGAAGATGGC TGCCAAGTGC 
GCAGACCTTA GGATGTGCCT CGATGTGTTC AAGGAAATCA TCCACAAAGG GCACGTGGTC 
ACAGAGGAGA CCTTCAGTTT CCTGCTCATG GGCTGCATCC AAGACAAGAA GACAGGCTTC 
CGGTACGCCC TCCAGGTGTG GCGGCTGATG CTGAGTCTAG GGCTACAGCC GAGCCGGGAC 
AGCTACAACC TGCTGTTGGT GGCAGCTCGG GACTGTGGCC TAGGGGACCC CCAGGTGGCC 
TCAGAGCTGC TTCTGAAGCC CAGGGAGGAG GCGACTGTGC TTCAGCCCCC AGTGAGCAGG 
CAGCGGCCAA GGAGGACAGC CCAGGCCAAG GCAGGCAACC TCATGTCAGC CATGCTGCAT 
GTGGAGGCCC TGGAGAGGCA GCTGTTTCTG GAACCTTCTC AGGCACTTGG GCCTCCAGAG 
CCTCCGGAAG CCAGAGTGCC CGGCAAGGCC CAACCAGAGG TGGATACTAA GGCAGAGCCC 
AGCCACACAG CAGCCCTCAC CGCAGTGGCC CTGAAGCCAC CTCCCGTGGA GCTGGAAGTC 
AACCTCCTGA CCCCCGGGGC CGTTCCCCCT ACAGTGGTCT CCTTTGGAAC GGTGACCACC 
CCAGCTGACC GGCTGGCCTT GATAGGGGGC CTGGAGGGCT TCCTGAGCAA GATGGCAGAG 
CACAGGCAGC AGCCCGACAT CAGGACCCTC ACGCTACTGG CCGAGGTGGT GGAGTCCGGG 
AGTCCTGCAG AGTCCTTGCT GCTGGCCCTC CTGGATGAGC ACCAGGTAGA GGCCGACCTG 
ACATTCTTTA ACACGCTGGT GAGAAAGAAG AGCAAGCTGG GAGACCTGGA GGGGGCCAAG 
GCGCTGTTGC CGGTCCTGGC AAAGAGGGGC CTCGTCCCCA ACCTGCAGAC ATTCTGCAAC 
CTGGCCATCG GGTGCCACAG GCCGAAGGAC GGTCTACAGC TTCTCACAGA CATGAAGAAG 
TCCCAGGTGA CCCCCAACAC TCACATCTAC AGTGCCCTCA TCAACGCGGC CATCAGGAAG 
CTGAACTACA CCTATCTCAT CAGCATCTTG AAGGACATGA AGCAGAACAG GGTCCCGGTG 
AACGAAGTGG TCATCCGCCA GCTGGAGTTT GCAGCCCAGT ACCCTCCCAC CTTTGACCGG 
TACCAAGGGA AGAACACCTA CCTGGAGAAG ATTGACGGCT TCCGAGCCTA TTACAAGCAG 
TGGCTGACAG TGATGCCCGC AGAGGAAACC CCGCACCCCT GGCAGAAGTT CCGGACCAAG 
CCCCAGGGGG ACCAGGACAC CGGCAAGGAG GCTGATGACG GATGTGCCCT TGGGGGCAGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondrial leucine tRNA level and PTCD1 are regulated in response to leucine starvation.
Amino acids46(7)1775-83(2014 Jul)
Schild C,Hahn D,Schaller A,Jackson CB,Rothen-Rutishauser B,Mirkovitch J,Nuoffer JM

Human pentatricopeptide proteins: only a few and what do they do?
RNA biology10(9)1433-8(2013)
Lightowlers RN,Chrzanowska-Lightowlers ZM

The role of mammalian PPR domain proteins in the regulation of mitochondrial gene expression.
Biochimica et biophysica acta1819(9-10)1008-16(2012 Sep-Oct)
Rackham O,Filipovska A

RNA processing in human mitochondria.
Cell cycle (Georgetown, Tex.)10(17)2904-16(2011 Sep)
Sanchez MI,Mercer TR,Davies SM,Shearwood AM,Nyg?rd KK,Richman TR,Mattick JS,Rackham O,Filipovska A

Pentatricopeptide repeat domain protein 1 lowers the levels of mitochondrial leucine tRNAs in cells.
Nucleic acids research37(17)5859-67(2009 Sep)
Rackham O,Davies SM,Shearwood AM,Hamilton KL,Whelan J,Filipovska A

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PTCD1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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