TAS2R50 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAS2R50
Entrez Gene ID	259296
Full Name	taste 2 receptor member 50
Synonyms	T2R50,T2R51,TAS2R51
General protein information	Preferred Names taste 2 receptor member 50 Names taste receptor type 2 member 50 taste receptor type 2 member 51 taste receptor, type 2, member 50
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.2
Summary	TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). See also TAS2R10 (MIM 604791).[supplied by OMIM, Mar 2008].
Disorder MIM:	609627

mRNA and Protein(s)

mRNA	Protein	Name
NM_176890.2	NP_795371.2	taste receptor type 2 member 50

Pathways from BioSystems

Homologies

Homo sapiens (human)	TAS2R50	NP_795371.2
Pan troglodytes (chimpanzee)	TAS2R50	NP_001009143.1
	LOC693513	XP_001081977.2

Gene Ontology
Bibliography

Related articles in PubMed

A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture.
Risso DS, Giuliani C, Antinucci M, Morini G, Garagnani P, Tofanelli S, Luiselli D
Appetite114240-247(2017 Jul)

KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.
Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ
Atherosclerosis220(2)456-62(2012 Feb)

Variations of specific non-candidate genes and risk of myocardial infarction: a replication study.
Koch W, Hoppmann P, Sch?mig A, Kastrati A
International journal of cardiology147(1)38-41(2011 Feb)

The molecular receptive ranges of human TAS2R bitter taste receptors.
Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M
Chemical senses35(2)157-70(2010 Feb)

The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin.
Behrens M, Brockhoff A, Batram C, Kuhn C, Appendino G, Meyerhof W
Journal of agricultural and food chemistry57(21)9860-6(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Assessment of KIF6 genotype is not useful in predicting low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.
Title: KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.

Observational study of gene-disease association. (HuGE Navigator)
Title: Variations of specific non-candidate genes and risk of myocardial infarction: a replication study.

TAS2R50 is activated by the natural bitter terpenoids andrographolide and amarogentin.
Title: The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene variants associated with ischemic stroke: the cardiovascular health study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.

The following TAS2R50 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAS2R50 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu32105	NM_176890.2 Latest version!	Homo sapiens taste 2 receptor member 50 (TAS2R50), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAS2R50 ( NM_176890.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_795371.2 Homo sapiens taste 2 receptor member 50 (TAS2R50), mRNA.

Price & Availability↑

CloneID	OHu32105
Clone ID Related Accession (Same CDS sequence)	NM_176890.2
Accession Version	NM_176890.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Homo sapiens(human)
Product	taste receptor type 2 member 50
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC112100.1. On Aug 9, 2007 this sequence version replaced NM_176890.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC112100.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000506868.1/ ENSP00000424040.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGATAACTT TTCTATACAT TTTTTTTTCA ATTCTAATAA TGGTTTTATT TGTTCTCGGA 
AACTTTGCCA ATGGCTTCAT AGCACTGGTA AATTTCATTG ACTGGGTGAA GAGAAAAAAG 
ATCTCCTCAG CTGACCAAAT TCTCACTGCT CTGGCGGTCT CCAGAATTGG TTTGCTCTGG 
GCATTATTAT TAAATTGGTA TTTAACTGTG TTGAATCCAG CTTTTTATAG TGTAGAATTA 
AGAATTACTT CTTATAATGC CTGGGTTGTA ACCAACCATT TCAGCATGTG GCTTGCTGCT 
AACCTCAGCA TATTTTATTT GCTCAAGATT GCCAATTTCT CCAACCTTCT TTTTCTTCAT 
TTAAAGAGGA GAGTTAGGAG TGTCATTCTG GTGATACTGT TGGGGACTTT GATATTTTTG 
GTTTGTCATC TTCTTGTGGC AAACATGGAT GAGAGTATGT GGGCAGAAGA ATATGAAGGA 
AACATGACTG GGAAGATGAA ATTGAGGAAT ACAGTACATC TTTCATATTT GACTGTAACT 
ACCCTATGGA GCTTCATACC CTTTACTCTG TCCCTGATAT CTTTTCTGAT GCTAATCTGT 
TCTCTGTGTA AACATCTCAA GAAGATGCAG CTCCATGGAG AAGGATCGCA AGATCTCAGC 
ACCAAGGTCC ACATAAAAGC TTTGCAAACT CTGATCTCCT TCCTCTTGTT ATGTGCCATT 
TTCTTTCTAT TCCTAATCGT TTCGGTTTGG AGTCCTAGGA GGCTGCGGAA TGACCCGGTT 
GTCATGGTTA GCAAGGCTGT TGGAAACATA TATCTTGCAT TCGACTCATT CATCCTAATT 
TGGAGAACCA AGAAGCTAAA ACACACCTTT CTTTTGATTT TGTGTCAGAT TAGGTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_795371.2
CDS	53..952
Translation	MITFLYIFFSILIMVLFVLGNFANGFIALVNFIDWVKRKKISSADQILTALAVSRIGLLWALLLNWYLTVLNPAFYSVELRITSYNAWVVTNHFSMWLAANLSIFYLLKIANFSNLLFLHLKRRVRSVILVILLGTLIFLVCHLLVANMDESMWAEEYEGNMTGKMKLRNTVHLSYLTVTTLWSFIPFTLSLISFLMLICSLCKHLKKMQLHGEGSQDLSTKVHIKALQTLISFLLLCAIFFLFLIVSVWSPRRLRNDPVVMVSKAVGNIYLAFDSFILIWRTKKLKHTFLLILCQIRC

Target ORF information:

RefSeq Version	NM_176890.2
Organism	Homo sapiens(human)
Definition	Homo sapiens taste 2 receptor member 50 (TAS2R50), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176890.2

ORF Insert Sequence:

ATGATAACTT TTCTATACAT TTTTTTTTCA ATTCTAATAA TGGTTTTATT TGTTCTCGGA 
AACTTTGCCA ATGGCTTCAT AGCACTGGTA AATTTCATTG ACTGGGTGAA GAGAAAAAAG 
ATCTCCTCAG CTGACCAAAT TCTCACTGCT CTGGCGGTCT CCAGAATTGG TTTGCTCTGG 
GCATTATTAT TAAATTGGTA TTTAACTGTG TTGAATCCAG CTTTTTATAG TGTAGAATTA 
AGAATTACTT CTTATAATGC CTGGGTTGTA ACCAACCATT TCAGCATGTG GCTTGCTGCT 
AACCTCAGCA TATTTTATTT GCTCAAGATT GCCAATTTCT CCAACCTTCT TTTTCTTCAT 
TTAAAGAGGA GAGTTAGGAG TGTCATTCTG GTGATACTGT TGGGGACTTT GATATTTTTG 
GTTTGTCATC TTCTTGTGGC AAACATGGAT GAGAGTATGT GGGCAGAAGA ATATGAAGGA 
AACATGACTG GGAAGATGAA ATTGAGGAAT ACAGTACATC TTTCATATTT GACTGTAACT 
ACCCTATGGA GCTTCATACC CTTTACTCTG TCCCTGATAT CTTTTCTGAT GCTAATCTGT 
TCTCTGTGTA AACATCTCAA GAAGATGCAG CTCCATGGAG AAGGATCGCA AGATCTCAGC 
ACCAAGGTCC ACATAAAAGC TTTGCAAACT CTGATCTCCT TCCTCTTGTT ATGTGCCATT 
TTCTTTCTAT TCCTAATCGT TTCGGTTTGG AGTCCTAGGA GGCTGCGGAA TGACCCGGTT 
GTCATGGTTA GCAAGGCTGT TGGAAACATA TATCTTGCAT TCGACTCATT CATCCTAATT 
TGGAGAACCA AGAAGCTAAA ACACACCTTT CTTTTGATTT TGTGTCAGAT TAGGTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture.
Appetite114240-247(2017 Jul)
Risso DS,Giuliani C,Antinucci M,Morini G,Garagnani P,Tofanelli S,Luiselli D

KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.
Atherosclerosis220(2)456-62(2012 Feb)
Akao H,Polisecki E,Kajinami K,Trompet S,Robertson M,Ford I,Jukema JW,de Craen AJ,Westendorp RG,Shepherd J,Packard C,Buckley BM,Schaefer EJ

Variations of specific non-candidate genes and risk of myocardial infarction: a replication study.
International journal of cardiology147(1)38-41(2011 Feb)
Koch W,Hoppmann P,Sch?mig A,Kastrati A

The molecular receptive ranges of human TAS2R bitter taste receptors.
Chemical senses35(2)157-70(2010 Feb)
Meyerhof W,Batram C,Kuhn C,Brockhoff A,Chudoba E,Bufe B,Appendino G,Behrens M

The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin.
Journal of agricultural and food chemistry57(21)9860-6(2009 Nov)
Behrens M,Brockhoff A,Batram C,Kuhn C,Appendino G,Meyerhof W

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TAS2R50 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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