ANAPC13 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ANAPC13
Entrez Gene ID	25847
Full Name	anaphase promoting complex subunit 13
Synonyms	APC13,SWM1
General protein information	Preferred Names anaphase promoting complex subunit 13 Names anaphase-promoting complex subunit 13 cyclosome subunit 13
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q22.2
Summary	This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008].
Disorder MIM:	614484

mRNA and Protein(s)

mRNA	Protein	Name
NM_015391.3	NP_056206.1	anaphase-promoting complex subunit 13
NM_001242374.1	NP_001229303.1	anaphase-promoting complex subunit 13
NM_001242375.1	NP_001229304.1	anaphase-promoting complex subunit 13
NM_015391.4	NP_056206.1	anaphase-promoting complex subunit 13

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	ANAPC13	NP_001264411.1
Danio rerio (zebrafish)	anapc13	XP_002666018.1
Homo sapiens (human)	ANAPC13	NP_056206.1
	ANAPC13	XP_001115306.1
Pan troglodytes (chimpanzee)	ANAPC13	XP_003950249.1
Bos taurus (cattle)	ANAPC13	NP_001106700.1
Canis lupus familiaris (dog)	ANAPC13	XP_851892.1
Mus musculus (house mouse)	Anapc13	NP_852059.1
Rattus norvegicus (Norway rat)	Anapc13	NP_001167454.1
Xenopus tropicalis (tropical clawed frog)	anapc13.1	NP_001017240.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.
Lee JJ, Essers JB, Kugathasan S, Escher JC, Lettre G, Butler JL, Stephens MC, Ramoni MF, Grand RJ, Hirschhorn J
Annals of human genetics74(6)489-97(2010 Nov)

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
Zhao J, Li M, Bradfield JP, Zhang H, Mentch FD, Wang K, Sleiman PM, Kim CE, Glessner JT, Hou C, Keating BJ, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Chiavacci RM, Berkowitz RI, Hakonarson H, Grant SF
BMC medical genetics1196(2010 Jun)

Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, H?rich? JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science (New York, N.Y.)328(5978)593-9(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.

Observational study of gene-disease association. (HuGE Navigator)
Title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.

The following ANAPC13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ANAPC13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06976	NM_001242375.1 Latest version!	Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu06976	NM_001242374.1 Latest version!	Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu06976	NM_015391.4 Latest version!	Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu06976	NM_015391.3	Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ANAPC13 ( NM_015391.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_056206.1 Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06976
Clone ID Related Accession (Same CDS sequence)	NM_015391.3 , NM_001242374.1 , NM_001242375.1 , NM_015391.4
Accession Version	NM_015391.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 225bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	anaphase-promoting complex subunit 13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG428689.1, BU852706.1, BC005398.1 and AK026550.1. On Nov 7, 2008 this sequence version replaced NM_015391.2. Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.643281.1, SRR1163658.127817.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1970526, SAMEA2142670 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAGTG AGGTTCAGAG AGATGGAAGG ATCTTGGATT TGATTGATGA TGCTTGGCGA 
GAAGACAAGC TGCCTTATGA GGATGTCGCA ATACCACTGA ATGAGCTTCC TGAACCTGAA 
CAAGACAATG GTGGCACCAC AGAATCTGTC AAAGAACAAG AAATGAAGTG GACAGACTTA 
GCCTTACAGT ACCTCCATGA GAATGTTCCC CCCATTGGAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056206.1
CDS	98..322
Translation	MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDLALQYLHENVPPIGN

Target ORF information:

RefSeq Version	NM_015391.3
Organism	Homo sapiens(human)
Definition	Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015391.3

ORF Insert Sequence:

ATGGACAGTG AGGTTCAGAG AGATGGAAGG ATCTTGGATT TGATTGATGA TGCTTGGCGA 
GAAGACAAGC TGCCTTATGA GGATGTCGCA ATACCACTGA ATGAGCTTCC TGAACCTGAA 
CAAGACAATG GTGGCACCAC AGAATCTGTC AAAGAACAAG AAATGAAGTG GACAGACTTA 
GCCTTACAGT ACCTCCATGA GAATGTTCCC CCCATTGGAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ANAPC13 ( NM_001242374.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001229303.1 Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu06976
Clone ID Related Accession (Same CDS sequence)	NM_015391.3 , NM_001242374.1 , NM_001242375.1 , NM_015391.4
Accession Version	NM_001242374.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 225bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	anaphase-promoting complex subunit 13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010207.18, AK290761.1, AV682398.1 and BU627217.1. On Jun 2, 2011 this sequence version replaced NR_024400.1. Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AK001285.1, SRR1660805.2038.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146, SAMN03267769 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAGTG AGGTTCAGAG AGATGGAAGG ATCTTGGATT TGATTGATGA TGCTTGGCGA 
GAAGACAAGC TGCCTTATGA GGATGTCGCA ATACCACTGA ATGAGCTTCC TGAACCTGAA 
CAAGACAATG GTGGCACCAC AGAATCTGTC AAAGAACAAG AAATGAAGTG GACAGACTTA 
GCCTTACAGT ACCTCCATGA GAATGTTCCC CCCATTGGAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001229303.1
CDS	732..956
Translation	MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDLALQYLHENVPPIGN

Target ORF information:

RefSeq Version	NM_001242374.1
Organism	Homo sapiens(human)
Definition	Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001242374.1

ORF Insert Sequence:

ATGGACAGTG AGGTTCAGAG AGATGGAAGG ATCTTGGATT TGATTGATGA TGCTTGGCGA 
GAAGACAAGC TGCCTTATGA GGATGTCGCA ATACCACTGA ATGAGCTTCC TGAACCTGAA 
CAAGACAATG GTGGCACCAC AGAATCTGTC AAAGAACAAG AAATGAAGTG GACAGACTTA 
GCCTTACAGT ACCTCCATGA GAATGTTCCC CCCATTGGAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ANAPC13 ( NM_001242375.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001229304.1 Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu06976
Clone ID Related Accession (Same CDS sequence)	NM_015391.3 , NM_001242374.1 , NM_001242375.1 , NM_015391.4
Accession Version	NM_001242375.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 225bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	anaphase-promoting complex subunit 13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010207.18, CN258858.1, AV682398.1 and BU627217.1. On Jun 2, 2011 this sequence version replaced NR_024401.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AL050051.1, SRR1163658.95043.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAGTG AGGTTCAGAG AGATGGAAGG ATCTTGGATT TGATTGATGA TGCTTGGCGA 
GAAGACAAGC TGCCTTATGA GGATGTCGCA ATACCACTGA ATGAGCTTCC TGAACCTGAA 
CAAGACAATG GTGGCACCAC AGAATCTGTC AAAGAACAAG AAATGAAGTG GACAGACTTA 
GCCTTACAGT ACCTCCATGA GAATGTTCCC CCCATTGGAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001229304.1
CDS	317..541
Translation	MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDLALQYLHENVPPIGN

Target ORF information:

RefSeq Version	NM_001242375.1
Organism	Homo sapiens(human)
Definition	Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001242375.1

ORF Insert Sequence:

ATGGACAGTG AGGTTCAGAG AGATGGAAGG ATCTTGGATT TGATTGATGA TGCTTGGCGA 
GAAGACAAGC TGCCTTATGA GGATGTCGCA ATACCACTGA ATGAGCTTCC TGAACCTGAA 
CAAGACAATG GTGGCACCAC AGAATCTGTC AAAGAACAAG AAATGAAGTG GACAGACTTA 
GCCTTACAGT ACCTCCATGA GAATGTTCCC CCCATTGGAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ANAPC13 ( NM_015391.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_056206.1 Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06976
Clone ID Related Accession (Same CDS sequence)	NM_015391.3 , NM_001242374.1 , NM_001242375.1 , NM_015391.4
Accession Version	NM_015391.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 225bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	anaphase-promoting complex subunit 13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005398.1 and AK026550.1. On Jun 2, 2019 this sequence version replaced NM_015391.3. Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.226192.1, SRR7410570.226193.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1970526, SAMEA2142670 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACAGTG AGGTTCAGAG AGATGGAAGG ATCTTGGATT TGATTGATGA TGCTTGGCGA 
GAAGACAAGC TGCCTTATGA GGATGTCGCA ATACCACTGA ATGAGCTTCC TGAACCTGAA 
CAAGACAATG GTGGCACCAC AGAATCTGTC AAAGAACAAG AAATGAAGTG GACAGACTTA 
GCCTTACAGT ACCTCCATGA GAATGTTCCC CCCATTGGAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056206.1
CDS	62..286
Translation	MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDLALQYLHENVPPIGN

Target ORF information:

RefSeq Version	NM_015391.4
Organism	Homo sapiens(human)
Definition	Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015391.4

ORF Insert Sequence:

ATGGACAGTG AGGTTCAGAG AGATGGAAGG ATCTTGGATT TGATTGATGA TGCTTGGCGA 
GAAGACAAGC TGCCTTATGA GGATGTCGCA ATACCACTGA ATGAGCTTCC TGAACCTGAA 
CAAGACAATG GTGGCACCAC AGAATCTGTC AAAGAACAAG AAATGAAGTG GACAGACTTA 
GCCTTACAGT ACCTCCATGA GAATGTTCCC CCCATTGGAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.
Annals of human genetics74(6)489-97(2010 Nov)
Lee JJ,Essers JB,Kugathasan S,Escher JC,Lettre G,Butler JL,Stephens MC,Ramoni MF,Grand RJ,Hirschhorn J

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
BMC medical genetics1196(2010 Jun)
Zhao J,Li M,Bradfield JP,Zhang H,Mentch FD,Wang K,Sleiman PM,Kim CE,Glessner JT,Hou C,Keating BJ,Thomas KA,Garris ML,Deliard S,Frackelton EC,Otieno FG,Chiavacci RM,Berkowitz RI,Hakonarson H,Grant SF

Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Science (New York, N.Y.)328(5978)593-9(2010 Apr)
Hutchins JR,Toyoda Y,Hegemann B,Poser I,H?rich? JK,Sykora MM,Augsburg M,Hudecz O,Buschhorn BA,Bulkescher J,Conrad C,Comartin D,Schleiffer A,Sarov M,Pozniakovsky A,Slabicki MM,Schloissnig S,Steinmacher I,Leuschner M,Ssykor A,Lawo S,Pelletier L,Stark H,Nasmyth K,Ellenberg J,Durbin R,Buchholz F,Mechtler K,Hyman AA,Peters JM

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ANAPC13 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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