FBXO33 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FBXO33
Entrez Gene ID	254170
Full Name	F-box protein 33
Synonyms	BMND12,Fbx33,c14_5247
General protein information	Preferred Names F-box protein 33 Names F-box only protein 33
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q21.1
Summary	This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis.[provided by RefSeq, Sep 2010].
Disorder MIM:	609103

mRNA and Protein(s)

mRNA	Protein	Name
NM_203301.3	NP_976046.1	F-box only protein 33

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Fbxo33	NP_001028328.2
Rattus norvegicus (Norway rat)	Fbxo33	NP_001101493.1
Canis lupus familiaris (dog)	FBXO33	XP_850997.1
Gallus gallus (chicken)	FBXO33	XP_426443.3
Pan troglodytes (chimpanzee)	FBXO33	XP_001149215.1
Danio rerio (zebrafish)	LOC567750	XP_696143.1
Homo sapiens (human)	FBXO33	NP_976046.1
	FBXO33	XP_001093383.1
Xenopus tropicalis (tropical clawed frog)	fbxo33	NP_001135667.1
Bos taurus (cattle)	FBXO33	NP_001192678.1

Gene Ontology
Bibliography

Related articles in PubMed

A High-Density Map for Navigating the Human Polycomb Complexome.
Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M, Beisel C
Cell reports17(2)583-595(2016 10)

Case-control genome-wide association study of persistent attention-deficit hyperactivity disorder identifies FBXO33 as a novel susceptibility gene for the disorder.
S?nchez-Mora C, Ramos-Quiroga JA, Bosch R, Corrales M, Garcia-Mart?nez I, Nogueira M, Pagerols M, Palomar G, Richarte V, Vidal R, Arias-Vasquez A, Bustamante M, Forns J, Gross-Lesch S, Guxens M, Hinney A, Hoogman M, Jacob C, Jacobsen KK, Kan CC, Kiemeney L, Kittel-Schneider S, Klein M, Onnink M, Rivero O, Zayats T, Buitelaar J, Faraone SV, Franke B, Haavik J, Johansson S, Lesch KP, Reif A, Sunyer J, Bay?s M, Casas M, Cormand B, Ribas?s M
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology40(4)915-26(2015 Mar)

Proteasomal degradation of the multifunctional regulator YB-1 is mediated by an F-Box protein induced during programmed cell death.
Lutz M, Wempe F, Bahr I, Zopf D, von Melchner H
FEBS letters580(16)3921-30(2006 Jul)

Systematic analysis and nomenclature of mammalian F-box proteins.
Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW
Genes & development18(21)2573-80(2004 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study findings show tentative evidence for the involvement of FBXO33 in the susceptibility to adult attention-deficit hyperactivity disorder.
Title: Case-control genome-wide association study of persistent attention-deficit hyperactivity disorder identifies FBXO33 as a novel susceptibility gene for the disorder.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following FBXO33 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FBXO33 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu23174	NM_203301.3 Latest version!	Homo sapiens F-box protein 33 (FBXO33), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FBXO33 ( NM_203301.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_976046.1 Homo sapiens F-box protein 33 (FBXO33), mRNA.

Price & Availability↑

CloneID	OHu23174
Clone ID Related Accession (Same CDS sequence)	NM_203301.3
Accession Version	NM_203301.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1668bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	F-box only protein 33
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC030611.1, BC053537.1, AL157791.4 and AI141232.1. This sequence is a reference standard in the RefSeqGene project. On Sep 2, 2010 this sequence version replaced NM_203301.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC053537.1, SRR1803617.83451.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148874, SAMEA2467147 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTGTTGT TCTTGTCAGT GCCGCAGCCC CGACCGCCGG GAGCTCGAAC CCGAGCCGGG 
GCCGCCCGGG TGGCGCGGTG GCGGCGGCTG CGGCTGCAGC AGCTGCGACG GCTGCGGGGG 
CTGCTCCGGG TACTGCGGGG GCGGCCGGGA GCCGGCAGCC GGCGGCGGGG CCGGATGGCT 
CTGTGCGGGC AGGCGGCGGG CGCTGCGTCG CTGCCCAGCG AGCTGATCGT GCACATCTTC 
TCTTTTCTGC CGGCGCCCGA CCGGCTGCGG GCCTCGGCCT CCTGCTCGCA CTGGCGTGAG 
TGCCTCTTCT ATCCGGCCCT GTGGCCCCAG CTCCGCATCT GCCTCCGCGT CTCGCCCGCG 
GAGCAGCCTC GGCTGGAATT CCTCATGCGC AAGTGCGGCT GGTTCGTGCG AGAGCTGCGT 
GTTGAATTCG CCGCCGAGAA CTATCTGAGC GGCGGTGGCC CAGGGGACGG AGGTGGCGCG 
GACACCGGGA CTGGAGGGGA GGAAGTCGAG GCCCTGCAGC TCTCAGCTCG TTGGCTGGAA 
GTGCTGCGCA CCTACTTGGA GCTGGTGCTT TGCGTGCTGG TCAGCATCCG GAACAACAGG 
AACCTTCAGA AGTTTAGTCT TTTTGGAGAC ATAAGTGTTC TACAACAGCA AGGAAGTTTG 
TCAAATACAT ACCTCAGCAA GGTGGACCCT GATGGCAAAA AAATTAAACA AATTCAGCAA 
CTGTTTGAAG AAATCCTGAG TAATAGTAGG CAACTGAAAT GGCTGTCCTG TGGGTTTATG 
CTGGAAATAG TAACCCCAAC ATCACTGTCA TCTCTCTCTA ATGCTGTTGC CAACACCATG 
GAGCACCTCA GTTTACTGGA CAATAATATT CCTGGTAACA GCACTCTTAT TACTGCAGTT 
GAACTGGAGC GATTTGTGAA TCTGCACTCA CTTGCCTTGG ATTTTTGTGA CTTTACAGCT 
GAGATGGCAA GAGTCTTAAC TGATAGCAAC CATGTGCCTT TGCAACGACT GTCTCTTCTG 
GTTCACAATG TTTCTGTAAT GCACAAGTCT CTGGACAACA TGCCAAATGA TGAGCATTGG 
AAAGCCCTGT CACGAAAGAG CACCAGCTTT CGGGTCTATA TAATGGCTTT TGATATCAAG 
AGTGAAGATA TGTTAAAGAT TCTGAAACCC AGTATACCAC TAGAGAGGAT TCATTTTGAT 
AGCTATATCA CTTGTGTTTC AGGGGCTATT GTTGATCTTA TATCCAGGCA ATATGACAAG 
TTCCTCACTC ATTTTATTTT AATGAATGAT GTGATTGACA CATCTGGTTT TCCAGATCTT 
AGTGACAACC GAAATGAAGA TCCGTTGGTT TTATTAGCAT GGAGGTGCAC AAAGCTCTCT 
CTTCTGGCAA TTCATGGTTA CACGGTGTGG GCACACAACC TCATTGCCAT TGCTCGTCTT 
CGGGGCTCTG ATCTGAAAGT GCTTGAAGTC ACCGAAGAAA GCATTGATTT TGACCAAGGT 
GAACTGGCCG ACCAGGATGT AGATCCAGTG CATAACCTTA TTGAGCAGGT ATCCCTGGGC 
CTGGGTCAAC CTTGGCATGC AGTCATGGAC ATCGAATCAC TCAGTGTCTT CACTGAACCA 
AATCGTCATT TTTACAGAGA GATGCAAAGC TTCAGTGAAG ACATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_976046.1
CDS	339..2006
Translation	MLLFLSVPQPRPPGARTRAGAARVARWRRLRLQQLRRLRGLLRVLRGRPGAGSRRRGRMALCGQAAGAASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQPRLEFLMRKCGWFVRELRVEFAAENYLSGGGPGDGGGADTGTGGEEVEALQLSARWLEVLRTYLELVLCVLVSIRNNRNLQKFSLFGDISVLQQQGSLSNTYLSKVDPDGKKIKQIQQLFEEILSNSRQLKWLSCGFMLEIVTPTSLSSLSNAVANTMEHLSLLDNNIPGNSTLITAVELERFVNLHSLALDFCDFTAEMARVLTDSNHVPLQRLSLLVHNVSVMHKSLDNMPNDEHWKALSRKSTSFRVYIMAFDIKSEDMLKILKPSIPLERIHFDSYITCVSGAIVDLISRQYDKFLTHFILMNDVIDTSGFPDLSDNRNEDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIDFDQGELADQDVDPVHNLIEQVSLGLGQPWHAVMDIESLSVFTEPNRHFYREMQSFSEDI

Target ORF information:

RefSeq Version	NM_203301.3
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 33 (FBXO33), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_203301.3

ORF Insert Sequence:

ATGTTGTTGT TCTTGTCAGT GCCGCAGCCC CGACCGCCGG GAGCTCGAAC CCGAGCCGGG 
GCCGCCCGGG TGGCGCGGTG GCGGCGGCTG CGGCTGCAGC AGCTGCGACG GCTGCGGGGG 
CTGCTCCGGG TACTGCGGGG GCGGCCGGGA GCCGGCAGCC GGCGGCGGGG CCGGATGGCT 
CTGTGCGGGC AGGCGGCGGG CGCTGCGTCG CTGCCCAGCG AGCTGATCGT GCACATCTTC 
TCTTTTCTGC CGGCGCCCGA CCGGCTGCGG GCCTCGGCCT CCTGCTCGCA CTGGCGTGAG 
TGCCTCTTCT ATCCGGCCCT GTGGCCCCAG CTCCGCATCT GCCTCCGCGT CTCGCCCGCG 
GAGCAGCCTC GGCTGGAATT CCTCATGCGC AAGTGCGGCT GGTTCGTGCG AGAGCTGCGT 
GTTGAATTCG CCGCCGAGAA CTATCTGAGC GGCGGTGGCC CAGGGGACGG AGGTGGCGCG 
GACACCGGGA CTGGAGGGGA GGAAGTCGAG GCCCTGCAGC TCTCAGCTCG TTGGCTGGAA 
GTGCTGCGCA CCTACTTGGA GCTGGTGCTT TGCGTGCTGG TCAGCATCCG GAACAACAGG 
AACCTTCAGA AGTTTAGTCT TTTTGGAGAC ATAAGTGTTC TACAACAGCA AGGAAGTTTG 
TCAAATACAT ACCTCAGCAA GGTGGACCCT GATGGCAAAA AAATTAAACA AATTCAGCAA 
CTGTTTGAAG AAATCCTGAG TAATAGTAGG CAACTGAAAT GGCTGTCCTG TGGGTTTATG 
CTGGAAATAG TAACCCCAAC ATCACTGTCA TCTCTCTCTA ATGCTGTTGC CAACACCATG 
GAGCACCTCA GTTTACTGGA CAATAATATT CCTGGTAACA GCACTCTTAT TACTGCAGTT 
GAACTGGAGC GATTTGTGAA TCTGCACTCA CTTGCCTTGG ATTTTTGTGA CTTTACAGCT 
GAGATGGCAA GAGTCTTAAC TGATAGCAAC CATGTGCCTT TGCAACGACT GTCTCTTCTG 
GTTCACAATG TTTCTGTAAT GCACAAGTCT CTGGACAACA TGCCAAATGA TGAGCATTGG 
AAAGCCCTGT CACGAAAGAG CACCAGCTTT CGGGTCTATA TAATGGCTTT TGATATCAAG 
AGTGAAGATA TGTTAAAGAT TCTGAAACCC AGTATACCAC TAGAGAGGAT TCATTTTGAT 
AGCTATATCA CTTGTGTTTC AGGGGCTATT GTTGATCTTA TATCCAGGCA ATATGACAAG 
TTCCTCACTC ATTTTATTTT AATGAATGAT GTGATTGACA CATCTGGTTT TCCAGATCTT 
AGTGACAACC GAAATGAAGA TCCGTTGGTT TTATTAGCAT GGAGGTGCAC AAAGCTCTCT 
CTTCTGGCAA TTCATGGTTA CACGGTGTGG GCACACAACC TCATTGCCAT TGCTCGTCTT 
CGGGGCTCTG ATCTGAAAGT GCTTGAAGTC ACCGAAGAAA GCATTGATTT TGACCAAGGT 
GAACTGGCCG ACCAGGATGT AGATCCAGTG CATAACCTTA TTGAGCAGGT ATCCCTGGGC 
CTGGGTCAAC CTTGGCATGC AGTCATGGAC ATCGAATCAC TCAGTGTCTT CACTGAACCA 
AATCGTCATT TTTACAGAGA GATGCAAAGC TTCAGTGAAG ACATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A High-Density Map for Navigating the Human Polycomb Complexome.
Cell reports17(2)583-595(2016 10)
Hauri S,Comoglio F,Seimiya M,Gerstung M,Glatter T,Hansen K,Aebersold R,Paro R,Gstaiger M,Beisel C

Case-control genome-wide association study of persistent attention-deficit hyperactivity disorder identifies FBXO33 as a novel susceptibility gene for the disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology40(4)915-26(2015 Mar)
S?nchez-Mora C,Ramos-Quiroga JA,Bosch R,Corrales M,Garcia-Mart?nez I,Nogueira M,Pagerols M,Palomar G,Richarte V,Vidal R,Arias-Vasquez A,Bustamante M,Forns J,Gross-Lesch S,Guxens M,Hinney A,Hoogman M,Jacob C,Jacobsen KK,Kan CC,Kiemeney L,Kittel-Schneider S,Klein M,Onnink M,Rivero O,Zayats T,Buitelaar J,Faraone SV,Franke B,Haavik J,Johansson S,Lesch KP,Reif A,Sunyer J,Bay?s M,Casas M,Cormand B,Ribas?s M

Proteasomal degradation of the multifunctional regulator YB-1 is mediated by an F-Box protein induced during programmed cell death.
FEBS letters580(16)3921-30(2006 Jul)
Lutz M,Wempe F,Bahr I,Zopf D,von Melchner H

Systematic analysis and nomenclature of mammalian F-box proteins.
Genes & development18(21)2573-80(2004 Nov)
Jin J,Cardozo T,Lovering RC,Elledge SJ,Pagano M,Harper JW

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FBXO33 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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