ABCB10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ABCB10
Entrez Gene ID	23456
Full Name	ATP binding cassette subfamily B member 10
Synonyms	EST20237,M-ABC2,MTABC2
General protein information	Preferred Names ATP binding cassette subfamily B member 10 Names ATP-binding cassette sub-family B member 10, mitochondrial ABC transporter 10 protein ATP-binding cassette transporter 10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 mitochondrial ATP-binding cassette 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q42.13
Summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. [provided by RefSeq, Jul 2008].
Disorder MIM:	605454

mRNA and Protein(s)

mRNA	Protein	Name
XM_011544136.2	XP_011542438.1	ATP-binding cassette sub-family B member 10, mitochondrial isoform X2
NM_012089.2	NP_036221.2	ATP-binding cassette sub-family B member 10, mitochondrial
XM_011544135.2	XP_011542437.1	ATP-binding cassette sub-family B member 10, mitochondrial isoform X1
XM_011544135.3	XP_011542437.1	ATP-binding cassette sub-family B member 10, mitochondrial isoform X1
NM_012089.3	NP_036221.2	ATP-binding cassette sub-family B member 10, mitochondrial

Pathways from BioSystems

Homologies

Homo sapiens (human)	ABCB10	NP_036221.2
Bos taurus (cattle)	ABCB10	XP_002698814.2
Rattus norvegicus (Norway rat)	Abcb10	NP_001012166.1
Caenorhabditis elegans (roundworm)	haf-3	NP_506927.2
Eremothecium gossypii	AGOS_ACR022W	NP_983425.2
Neurospora crassa	NCU04117	XP_961273.2
Canis lupus familiaris (dog)	ABCB10	XP_005618913.1
Kluyveromyces lactis	KLLA0D00748g	XP_453105.1
Schizosaccharomyces pombe (fission yeast)	mdl1	NP_595751.1
Arabidopsis thaliana (thale cress)	TAP2	NP_198720.2
Mus musculus (house mouse)	Abcb10	NP_062425.1
Gallus gallus (chicken)	ABCB10	XP_419578.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002717	XP_312209.4
Caenorhabditis elegans (roundworm)	haf-1	NP_503098.2
Saccharomyces cerevisiae (baker's yeast)	MDL2	NP_015053.2
Pan troglodytes (chimpanzee)	ABCB10	XP_003308870.1
	ABCB10	XP_001082734.1
Danio rerio (zebrafish)	abcb10	XP_001343218.3
Drosophila melanogaster (fruit fly)	CG3156	NP_569844.2
Magnaporthe oryzae (rice blast fungus)	MGG_06878	XP_003709605.1
Oryza sativa (rice)	Os03g0755100	NP_001051311.1

Gene Ontology
Bibliography

Related articles in PubMed

Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes.
Seguin A, Takahashi-Makise N, Yien YY, Huston NC, Whitman JC, Musso G, Wallace JA, Bradley T, Bergonia HA, Kafina MD, Matsumoto M, Igarashi K, Phillips JD, Paw BH, Kaplan J, Ward DM
The Journal of biological chemistry292(39)16284-16299(2017 09)

ABCB10 depletion reduces unfolded protein response in mitochondria.
Yano M
Biochemical and biophysical research communications486(2)465-469(2017 04)

Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
Reiner AP, Hartiala J, Zeller T, Bis JC, Dupuis J, Fornage M, Baumert J, Kleber ME, Wild PS, Baldus S, Bielinski SJ, Fontes JD, Illig T, Keating BJ, Lange LA, Ojeda F, M?ller-Nurasyid M, Munzel TF, Psaty BM, Rice K, Rotter JI, Schnabel RB, Tang WH, Thorand B, Erdmann J, , Jacobs DR Jr, Wilson JG, Koenig W, Tracy RP, Blankenberg S, M?rz W, Gross MD, Benjamin EJ, Hazen SL, Allayee H
Human molecular genetics22(16)3381-93(2013 Aug)

ATP-binding cassette B10 regulates early steps of heme synthesis.
Bayeva M, Khechaduri A, Wu R, Burke MA, Wasserstrom JA, Singh N, Liesa M, Shirihai OS, Langer NB, Paw BH, Ardehali H
Circulation research113(3)279-87(2013 Jul)

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.
Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, Marsden BD, von Delft F, Bullock AN, Gileadi O, Burgess-Brown NA, Carpenter EP
Proceedings of the National Academy of Sciences of the United States of America110(24)9710-5(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that ABCB10 silencing results in alteration in heme biosynthesis transcriptional profile due to repression by transcriptional regulator BACH1. (ABCB10 = ATP-binding cassette, sub-family B [MDR-TAP], member 10; BACH1 = BTB and CNC homology 1, basic leucine zipper transcription factor 1)
Title: Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes.

ABCB10 is involved in unfolded protein response signaling pathway, although it probably does not participate in peptide export from mitochondria.
Title: ABCB10 depletion reduces unfolded protein response in mitochondria.

ABCB10 is not a heme exporter but is required for the early mitochondrial steps of heme biosynthesis.
Title: ATP-binding cassette B10 regulates early steps of heme synthesis.

Data indicate that ABCB10 may exist in an open-inwards conformation when nucleotide is bound.
Title: Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.

ABCB10 is required for primitive erythropoiesis and to protect from oxidative stress associated with cardiac ischemia-reperfusion in mice. Antioxidants can rescue the defects associated with ABCB10 loss-of-function in mice.
Title: Mitochondrial ABC transporters function: the role of ABCB10 (ABC-me) as a novel player in cellular handling of reactive oxygen species.

The following ABCB10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ABCB10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08914	NM_012089.3 Latest version!	Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu35007	XM_011544135.3 Latest version!	Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu66200	XM_011544136.2 Latest version!	Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu35007	XM_011544135.2	Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu08914	NM_012089.2	Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ABCB10 ( NM_012089.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036221.2 Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10), mRNA.

Price & Availability↑

CloneID	OHu08914
Clone ID Related Accession (Same CDS sequence)	NM_012089.2 , NM_012089.3
Accession Version	NM_012089.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-23
Organism	Homo sapiens(human)
Product	ATP-binding cassette sub-family B member 10, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF216833.1, AB013380.1 and BC064930.1. On Mar 28, 2008 this sequence version replaced NM_012089.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF216833.1, BC064930.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGAGGCC CCCCTGCCTG GCCGCTGCGG CTGCTCGAGC CACCGAGCCC TGCCGAGCCA 
GGTCGGCTCC TGCCGGTAGC CTGCGTGTGG GCCGCGGCCA GCCGCGTTCC CGGGTCCCTA 
TCGCCGTTCA CTGGCCTGAG GCCGGCGCGG CTATGGGGCG CGGGGCCCGC GCTGCTCTGG 
GGCGTTGGAG CCGCGCGCCG CTGGAGGAGC GGCTGCCGGG GCGGGGGTCC GGGCGCCTCG 
CGGGGCGTCC TGGGCCTCGC GCGGCTCCTG GGGCTGTGGG CTCGCGGCCC CGGCAGCTGC 
AGGTGCGGGG CTTTTGCCGG GCCAGGCGCT CCTCGGCTCC CGCGCGCCCG GTTCCCGGGC 
GGTCCCGCAG CCGCTGCCTG GGCAGGGGAC GAGGCCTGGC GGCGCGGGCC GGCGGCGCCT 
CCCGGGGACA AGGGGCGGCT GCGCCCCGCA GCGGCCGGAC TCCCGGAGGC CCGGAAGCTC 
CTGGGGCTGG CGTACCCTGA GCGCCGGAGG CTGGCAGCTG CGGTTGGATT TCTCACGATG 
TCCAGTGTTA TCTCCATGTC TGCCCCTTTC TTCCTGGGGA AGATCATTGA TGTCATCTAT 
ACCAACCCCA CTGTGGACTA CAGCGACAAC CTGACCCGCC TCTGCCTAGG GCTCAGTGCC 
GTGTTTCTGT GTGGTGCTGC CGCCAATGCC ATTCGTGTCT ACCTCATGCA AACTTCAGGT 
CAGCGCATTG TGAATAGGCT GAGAACTTCA TTATTCTCCT CCATTCTGAG GCAGGAGGTT 
GCTTTCTTTG ACAAGACTCG CACAGGAGAA TTGATTAACC GCCTCTCATC AGACACTGCA 
CTCCTGGGGC GCTCAGTGAC TGAAAACCTC TCAGATGGGC TCAGGGCCGG GGCCCAGGCT 
TCCGTAGGCA TCAGTATGAT GTTTTTTGTC TCACCTAATC TGGCCACCTT TGTTTTGAGC 
GTGGTGCCTC CAGTGTCAAT CATTGCTGTA ATTTATGGGC GATATCTACG GAAACTGACC 
AAAGTCACTC AGGATTCCCT GGCACAAGCC ACTCAGCTAG CTGAGGAACG TATTGGAAAT 
GTAAGAACTG TTCGAGCTTT TGGGAAAGAA ATGACTGAAA TCGAGAAATA TGCCAGCAAA 
GTGGACCATG TAATGCAGTT AGCAAGGAAA GAGGCATTCG CCCGGGCTGG TTTCTTTGGA 
GCAACTGGGC TCTCCGGAAA CCTGATCGTG CTTTCTGTCC TGTACAAAGG AGGGCTGCTG 
ATGGGCAGTG CCCACATGAC CGTGGGTGAA CTCTCTTCCT TCCTAATGTA TGCTTTCTGG 
GTTGGAATAA GCATTGGAGG TCTGAGCTCT TTCTACTCGG AGCTGATGAA AGGACTGGGT 
GCAGGGGGGC GCCTCTGGGA GCTCCTGGAG AGAGAGCCCA AGCTGCCTTT TAACGAGGGG 
GTCATCTTAA ATGAGAAAAG CTTCCAGGGT GCTTTGGAGT TTAAGAACGT GCATTTTGCC 
TATCCAGCTC GCCCAGAGGT GCCCATATTT CAGGATTTCA GCCTTTCCAT TCCGTCAGGA 
TCTGTCACGG CACTGGTTGG CCCAAGTGGT TCTGGCAAAT CAACAGTGCT TTCACTCCTG 
CTGAGGTTGT ACGACCCTGC TTCTGGAACT ATTAGTCTTG ATGGCCATGA CATCCGTCAG 
CTAAACCCAG TGTGGCTGAG ATCCAAAATT GGGACAGTGA GTCAGGAACC CATTTTGTTT 
TCTTGCTCTA TTGCTGAGAA CATTGCTTAT GGTGCTGATG ACCCTTCCTC TGTGACCGCT 
GAGGAAATCC AGAGAGTGGC TGAAGTGGCC AATGCAGTGG CCTTCATCCG GAATTTCCCC 
CAAGGGTTCA ACACTGTGGT TGGAGAAAAG GGTGTTCTCC TCTCAGGTGG GCAGAAACAG 
CGGATTGCGA TTGCCCGTGC TCTGCTAAAG AATCCCAAAA TTCTTCTCCT AGATGAAGCA 
ACCAGTGCGC TGGATGCCGA AAATGAGTAC CTTGTTCAAG AAGCTCTAGA TCGACTGATG 
GATGGAAGAA CGGTGTTAGT TATTGCCCAT CGTCTGTCCA CCATTAAGAA TGCTAATATG 
GTTGCTGTTC TTGACCAAGG AAAAATTACT GAATATGGAA AACATGAAGA GCTGCTTTCA 
AAACCAAATG GGATATACAG AAAACTAATG AACAAACAAA GTTTTATTTC AGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036221.2
CDS	44..2260
Translation	MRGPPAWPLRLLEPPSPAEPGRLLPVACVWAAASRVPGSLSPFTGLRPARLWGAGPALLWGVGAARRWRSGCRGGGPGASRGVLGLARLLGLWARGPGSCRCGAFAGPGAPRLPRARFPGGPAAAAWAGDEAWRRGPAAPPGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSFISA

Target ORF information:

RefSeq Version	NM_012089.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012089.2

ORF Insert Sequence:

ATGCGAGGCC CCCCTGCCTG GCCGCTGCGG CTGCTCGAGC CACCGAGCCC TGCCGAGCCA 
GGTCGGCTCC TGCCGGTAGC CTGCGTGTGG GCCGCGGCCA GCCGCGTTCC CGGGTCCCTA 
TCGCCGTTCA CTGGCCTGAG GCCGGCGCGG CTATGGGGCG CGGGGCCCGC GCTGCTCTGG 
GGCGTTGGAG CCGCGCGCCG CTGGAGGAGC GGCTGCCGGG GCGGGGGTCC GGGCGCCTCG 
CGGGGCGTCC TGGGCCTCGC GCGGCTCCTG GGGCTGTGGG CTCGCGGCCC CGGCAGCTGC 
AGGTGCGGGG CTTTTGCCGG GCCAGGCGCT CCTCGGCTCC CGCGCGCCCG GTTCCCGGGC 
GGTCCCGCAG CCGCTGCCTG GGCAGGGGAC GAGGCCTGGC GGCGCGGGCC GGCGGCGCCT 
CCCGGGGACA AGGGGCGGCT GCGCCCCGCA GCGGCCGGAC TCCCGGAGGC CCGGAAGCTC 
CTGGGGCTGG CGTACCCTGA GCGCCGGAGG CTGGCAGCTG CGGTTGGATT TCTCACGATG 
TCCAGTGTTA TCTCCATGTC TGCCCCTTTC TTCCTGGGGA AGATCATTGA TGTCATCTAT 
ACCAACCCCA CTGTGGACTA CAGCGACAAC CTGACCCGCC TCTGCCTAGG GCTCAGTGCC 
GTGTTTCTGT GTGGTGCTGC CGCCAATGCC ATTCGTGTCT ACCTCATGCA AACTTCAGGT 
CAGCGCATTG TGAATAGGCT GAGAACTTCA TTATTCTCCT CCATTCTGAG GCAGGAGGTT 
GCTTTCTTTG ACAAGACTCG CACAGGAGAA TTGATTAACC GCCTCTCATC AGACACTGCA 
CTCCTGGGGC GCTCAGTGAC TGAAAACCTC TCAGATGGGC TCAGGGCCGG GGCCCAGGCT 
TCCGTAGGCA TCAGTATGAT GTTTTTTGTC TCACCTAATC TGGCCACCTT TGTTTTGAGC 
GTGGTGCCTC CAGTGTCAAT CATTGCTGTA ATTTATGGGC GATATCTACG GAAACTGACC 
AAAGTCACTC AGGATTCCCT GGCACAAGCC ACTCAGCTAG CTGAGGAACG TATTGGAAAT 
GTAAGAACTG TTCGAGCTTT TGGGAAAGAA ATGACTGAAA TCGAGAAATA TGCCAGCAAA 
GTGGACCATG TAATGCAGTT AGCAAGGAAA GAGGCATTCG CCCGGGCTGG TTTCTTTGGA 
GCAACTGGGC TCTCCGGAAA CCTGATCGTG CTTTCTGTCC TGTACAAAGG AGGGCTGCTG 
ATGGGCAGTG CCCACATGAC CGTGGGTGAA CTCTCTTCCT TCCTAATGTA TGCTTTCTGG 
GTTGGAATAA GCATTGGAGG TCTGAGCTCT TTCTACTCGG AGCTGATGAA AGGACTGGGT 
GCAGGGGGGC GCCTCTGGGA GCTCCTGGAG AGAGAGCCCA AGCTGCCTTT TAACGAGGGG 
GTCATCTTAA ATGAGAAAAG CTTCCAGGGT GCTTTGGAGT TTAAGAACGT GCATTTTGCC 
TATCCAGCTC GCCCAGAGGT GCCCATATTT CAGGATTTCA GCCTTTCCAT TCCGTCAGGA 
TCTGTCACGG CACTGGTTGG CCCAAGTGGT TCTGGCAAAT CAACAGTGCT TTCACTCCTG 
CTGAGGTTGT ACGACCCTGC TTCTGGAACT ATTAGTCTTG ATGGCCATGA CATCCGTCAG 
CTAAACCCAG TGTGGCTGAG ATCCAAAATT GGGACAGTGA GTCAGGAACC CATTTTGTTT 
TCTTGCTCTA TTGCTGAGAA CATTGCTTAT GGTGCTGATG ACCCTTCCTC TGTGACCGCT 
GAGGAAATCC AGAGAGTGGC TGAAGTGGCC AATGCAGTGG CCTTCATCCG GAATTTCCCC 
CAAGGGTTCA ACACTGTGGT TGGAGAAAAG GGTGTTCTCC TCTCAGGTGG GCAGAAACAG 
CGGATTGCGA TTGCCCGTGC TCTGCTAAAG AATCCCAAAA TTCTTCTCCT AGATGAAGCA 
ACCAGTGCGC TGGATGCCGA AAATGAGTAC CTTGTTCAAG AAGCTCTAGA TCGACTGATG 
GATGGAAGAA CGGTGTTAGT TATTGCCCAT CGTCTGTCCA CCATTAAGAA TGCTAATATG 
GTTGCTGTTC TTGACCAAGG AAAAATTACT GAATATGGAA AACATGAAGA GCTGCTTTCA 
AAACCAAATG GGATATACAG AAAACTAATG AACAAACAAA GTTTTATTTC AGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ABCB10 ( NM_012089.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036221.2 Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10), mRNA.

Price & Availability↑

CloneID	OHu08914
Clone ID Related Accession (Same CDS sequence)	NM_012089.2 , NM_012089.3
Accession Version	NM_012089.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	ATP-binding cassette sub-family B member 10, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121990.34, AF216833.1, AB013380.1 and BC064930.1. On Nov 22, 2018 this sequence version replaced NM_012089.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB013380.1, AF216833.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000344517.5/ ENSP00000355637.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGAGGCC CCCCTGCCTG GCCGCTGCGG CTGCTCGAGC CACCGAGCCC TGCCGAGCCA 
GGTCGGCTCC TGCCGGTAGC CTGCGTGTGG GCCGCGGCCA GCCGCGTTCC CGGGTCCCTA 
TCGCCGTTCA CTGGCCTGAG GCCGGCGCGG CTATGGGGCG CGGGGCCCGC GCTGCTCTGG 
GGCGTTGGAG CCGCGCGCCG CTGGAGGAGC GGCTGCCGGG GCGGGGGTCC GGGCGCCTCG 
CGGGGCGTCC TGGGCCTCGC GCGGCTCCTG GGGCTGTGGG CTCGCGGCCC CGGCAGCTGC 
AGGTGCGGGG CTTTTGCCGG GCCAGGCGCT CCTCGGCTCC CGCGCGCCCG GTTCCCGGGC 
GGTCCCGCAG CCGCTGCCTG GGCAGGGGAC GAGGCCTGGC GGCGCGGGCC GGCGGCGCCT 
CCCGGGGACA AGGGGCGGCT GCGCCCCGCA GCGGCCGGAC TCCCGGAGGC CCGGAAGCTC 
CTGGGGCTGG CGTACCCTGA GCGCCGGAGG CTGGCAGCTG CGGTTGGATT TCTCACGATG 
TCCAGTGTTA TCTCCATGTC TGCCCCTTTC TTCCTGGGGA AGATCATTGA TGTCATCTAT 
ACCAACCCCA CTGTGGACTA CAGCGACAAC CTGACCCGCC TCTGCCTAGG GCTCAGTGCC 
GTGTTTCTGT GTGGTGCTGC CGCCAATGCC ATTCGTGTCT ACCTCATGCA AACTTCAGGT 
CAGCGCATTG TGAATAGGCT GAGAACTTCA TTATTCTCCT CCATTCTGAG GCAGGAGGTT 
GCTTTCTTTG ACAAGACTCG CACAGGAGAA TTGATTAACC GCCTCTCATC AGACACTGCA 
CTCCTGGGGC GCTCAGTGAC TGAAAACCTC TCAGATGGGC TCAGGGCCGG GGCCCAGGCT 
TCCGTAGGCA TCAGTATGAT GTTTTTTGTC TCACCTAATC TGGCCACCTT TGTTTTGAGC 
GTGGTGCCTC CAGTGTCAAT CATTGCTGTA ATTTATGGGC GATATCTACG GAAACTGACC 
AAAGTCACTC AGGATTCCCT GGCACAAGCC ACTCAGCTAG CTGAGGAACG TATTGGAAAT 
GTAAGAACTG TTCGAGCTTT TGGGAAAGAA ATGACTGAAA TCGAGAAATA TGCCAGCAAA 
GTGGACCATG TAATGCAGTT AGCAAGGAAA GAGGCATTCG CCCGGGCTGG TTTCTTTGGA 
GCAACTGGGC TCTCCGGAAA CCTGATCGTG CTTTCTGTCC TGTACAAAGG AGGGCTGCTG 
ATGGGCAGTG CCCACATGAC CGTGGGTGAA CTCTCTTCCT TCCTAATGTA TGCTTTCTGG 
GTTGGAATAA GCATTGGAGG TCTGAGCTCT TTCTACTCGG AGCTGATGAA AGGACTGGGT 
GCAGGGGGGC GCCTCTGGGA GCTCCTGGAG AGAGAGCCCA AGCTGCCTTT TAACGAGGGG 
GTCATCTTAA ATGAGAAAAG CTTCCAGGGT GCTTTGGAGT TTAAGAACGT GCATTTTGCC 
TATCCAGCTC GCCCAGAGGT GCCCATATTT CAGGATTTCA GCCTTTCCAT TCCGTCAGGA 
TCTGTCACGG CACTGGTTGG CCCAAGTGGT TCTGGCAAAT CAACAGTGCT TTCACTCCTG 
CTGAGGTTGT ACGACCCTGC TTCTGGAACT ATTAGTCTTG ATGGCCATGA CATCCGTCAG 
CTAAACCCAG TGTGGCTGAG ATCCAAAATT GGGACAGTGA GTCAGGAACC CATTTTGTTT 
TCTTGCTCTA TTGCTGAGAA CATTGCTTAT GGTGCTGATG ACCCTTCCTC TGTGACCGCT 
GAGGAAATCC AGAGAGTGGC TGAAGTGGCC AATGCAGTGG CCTTCATCCG GAATTTCCCC 
CAAGGGTTCA ACACTGTGGT TGGAGAAAAG GGTGTTCTCC TCTCAGGTGG GCAGAAACAG 
CGGATTGCGA TTGCCCGTGC TCTGCTAAAG AATCCCAAAA TTCTTCTCCT AGATGAAGCA 
ACCAGTGCGC TGGATGCCGA AAATGAGTAC CTTGTTCAAG AAGCTCTAGA TCGACTGATG 
GATGGAAGAA CGGTGTTAGT TATTGCCCAT CGTCTGTCCA CCATTAAGAA TGCTAATATG 
GTTGCTGTTC TTGACCAAGG AAAAATTACT GAATATGGAA AACATGAAGA GCTGCTTTCA 
AAACCAAATG GGATATACAG AAAACTAATG AACAAACAAA GTTTTATTTC AGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036221.2
CDS	56..2272
Translation	MRGPPAWPLRLLEPPSPAEPGRLLPVACVWAAASRVPGSLSPFTGLRPARLWGAGPALLWGVGAARRWRSGCRGGGPGASRGVLGLARLLGLWARGPGSCRCGAFAGPGAPRLPRARFPGGPAAAAWAGDEAWRRGPAAPPGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSFISA

Target ORF information:

RefSeq Version	NM_012089.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012089.3

ORF Insert Sequence:

ATGCGAGGCC CCCCTGCCTG GCCGCTGCGG CTGCTCGAGC CACCGAGCCC TGCCGAGCCA 
GGTCGGCTCC TGCCGGTAGC CTGCGTGTGG GCCGCGGCCA GCCGCGTTCC CGGGTCCCTA 
TCGCCGTTCA CTGGCCTGAG GCCGGCGCGG CTATGGGGCG CGGGGCCCGC GCTGCTCTGG 
GGCGTTGGAG CCGCGCGCCG CTGGAGGAGC GGCTGCCGGG GCGGGGGTCC GGGCGCCTCG 
CGGGGCGTCC TGGGCCTCGC GCGGCTCCTG GGGCTGTGGG CTCGCGGCCC CGGCAGCTGC 
AGGTGCGGGG CTTTTGCCGG GCCAGGCGCT CCTCGGCTCC CGCGCGCCCG GTTCCCGGGC 
GGTCCCGCAG CCGCTGCCTG GGCAGGGGAC GAGGCCTGGC GGCGCGGGCC GGCGGCGCCT 
CCCGGGGACA AGGGGCGGCT GCGCCCCGCA GCGGCCGGAC TCCCGGAGGC CCGGAAGCTC 
CTGGGGCTGG CGTACCCTGA GCGCCGGAGG CTGGCAGCTG CGGTTGGATT TCTCACGATG 
TCCAGTGTTA TCTCCATGTC TGCCCCTTTC TTCCTGGGGA AGATCATTGA TGTCATCTAT 
ACCAACCCCA CTGTGGACTA CAGCGACAAC CTGACCCGCC TCTGCCTAGG GCTCAGTGCC 
GTGTTTCTGT GTGGTGCTGC CGCCAATGCC ATTCGTGTCT ACCTCATGCA AACTTCAGGT 
CAGCGCATTG TGAATAGGCT GAGAACTTCA TTATTCTCCT CCATTCTGAG GCAGGAGGTT 
GCTTTCTTTG ACAAGACTCG CACAGGAGAA TTGATTAACC GCCTCTCATC AGACACTGCA 
CTCCTGGGGC GCTCAGTGAC TGAAAACCTC TCAGATGGGC TCAGGGCCGG GGCCCAGGCT 
TCCGTAGGCA TCAGTATGAT GTTTTTTGTC TCACCTAATC TGGCCACCTT TGTTTTGAGC 
GTGGTGCCTC CAGTGTCAAT CATTGCTGTA ATTTATGGGC GATATCTACG GAAACTGACC 
AAAGTCACTC AGGATTCCCT GGCACAAGCC ACTCAGCTAG CTGAGGAACG TATTGGAAAT 
GTAAGAACTG TTCGAGCTTT TGGGAAAGAA ATGACTGAAA TCGAGAAATA TGCCAGCAAA 
GTGGACCATG TAATGCAGTT AGCAAGGAAA GAGGCATTCG CCCGGGCTGG TTTCTTTGGA 
GCAACTGGGC TCTCCGGAAA CCTGATCGTG CTTTCTGTCC TGTACAAAGG AGGGCTGCTG 
ATGGGCAGTG CCCACATGAC CGTGGGTGAA CTCTCTTCCT TCCTAATGTA TGCTTTCTGG 
GTTGGAATAA GCATTGGAGG TCTGAGCTCT TTCTACTCGG AGCTGATGAA AGGACTGGGT 
GCAGGGGGGC GCCTCTGGGA GCTCCTGGAG AGAGAGCCCA AGCTGCCTTT TAACGAGGGG 
GTCATCTTAA ATGAGAAAAG CTTCCAGGGT GCTTTGGAGT TTAAGAACGT GCATTTTGCC 
TATCCAGCTC GCCCAGAGGT GCCCATATTT CAGGATTTCA GCCTTTCCAT TCCGTCAGGA 
TCTGTCACGG CACTGGTTGG CCCAAGTGGT TCTGGCAAAT CAACAGTGCT TTCACTCCTG 
CTGAGGTTGT ACGACCCTGC TTCTGGAACT ATTAGTCTTG ATGGCCATGA CATCCGTCAG 
CTAAACCCAG TGTGGCTGAG ATCCAAAATT GGGACAGTGA GTCAGGAACC CATTTTGTTT 
TCTTGCTCTA TTGCTGAGAA CATTGCTTAT GGTGCTGATG ACCCTTCCTC TGTGACCGCT 
GAGGAAATCC AGAGAGTGGC TGAAGTGGCC AATGCAGTGG CCTTCATCCG GAATTTCCCC 
CAAGGGTTCA ACACTGTGGT TGGAGAAAAG GGTGTTCTCC TCTCAGGTGG GCAGAAACAG 
CGGATTGCGA TTGCCCGTGC TCTGCTAAAG AATCCCAAAA TTCTTCTCCT AGATGAAGCA 
ACCAGTGCGC TGGATGCCGA AAATGAGTAC CTTGTTCAAG AAGCTCTAGA TCGACTGATG 
GATGGAAGAA CGGTGTTAGT TATTGCCCAT CGTCTGTCCA CCATTAAGAA TGCTAATATG 
GTTGCTGTTC TTGACCAAGG AAAAATTACT GAATATGGAA AACATGAAGA GCTGCTTTCA 
AAACCAAATG GGATATACAG AAAACTAATG AACAAACAAA GTTTTATTTC AGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ABCB10 ( XM_011544135.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011542437.1 Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10), transcript variant X1, mRNA.

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CloneID	OHu35007
Clone ID Related Accession (Same CDS sequence)	XM_011544135.2 , XM_011544135.3
Accession Version	XM_011544135.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1680bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	ATP-binding cassette sub-family B member 10, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011544135.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGTG TTATCTCCAT GTCTGCCCCT TTCTTCCTGG GGAAGATCAT TGATGTCATC 
TATACCAACC CCACTGTGGA CTACAGCGAC AACCTGACCC GCCTCTGCCT AGGGCTCAGT 
GCCGTGTTTC TGTGTGGTGC TGCCGCCAAT GCCATTCGTG TCTACCTCAT GCAAACTTCA 
GGTCAGCGCA TTGTGAATAG GCTGAGAACT TCATTATTCT CCTCCATTCT GAGGCAGGAG 
GTTGCTTTCT TTGACAAGAC TCGCACAGGA GAATTGATTA ACCGCCTCTC ATCAGACACT 
GCACTCCTGG GGCGCTCAGT GACTGAAAAC CTCTCAGATG GGCTCAGGGC CGGGGCCCAG 
GCTTCCGTAG GCATCAGTAT GATGTTTTTT GTCTCACCTA ATCTGGCCAC CTTTGTTTTG 
AGCGTGGTGC CTCCAGTGTC AATCATTGCT GTAATTTATG GGCGATATCT ACGGAAACTG 
ACCAAAGTCA CTCAGGATTC CCTGGCACAA GCCACTCAGC TAGCTGAGGA ACGTATTGGA 
AATGTAAGAA CTGTTCGAGC TTTTGGGAAA GAAATGACTG AAATCGAGAA ATATGCCAGC 
AAAGTGGACC ATGTAATGCA GTTAGCAAGG AAAGAGGCAT TCGCCCGGGC TGGTTTCTTT 
GGAGCAACTG GGCTCTCCGG AAACCTGATC GTGCTTTCTG TCCTGTACAA AGGAGGGCTG 
CTGATGGGCA GTGCCCACAT GACCGTGGGT GAACTCTCTT CCTTCCTAAT GTATGCTTTC 
TGGGTTGGAA TAAGCATTGG AGGTCTGAGC TCTTTCTACT CGGAGCTGAT GAAAGGACTG 
GGTGCAGGGG GGCGCCTCTG GGAGCTCCTG GAGAGAGAGC CCAAGCTGCC TTTTAACGAG 
GGGGTCATCT TAAATGAGAA AAGCTTCCAG GGTGCTTTGG AGTTTAAGAA CGTGCATTTT 
GCCTATCCAG CTCGCCCAGA GGTGCCCATA TTTCAGGATT TCAGCCTTTC CATTCCGTCA 
GGATCTGTCA CGGCACTGGT TGGCCCAAGT GGTTCTGGCA AATCAACAGT GCTTTCACTC 
CTGCTGAGGT TGTACGACCC TGCTTCTGGA ACTATTAGTC TTGATGGCCA TGACATCCGT 
CAGCTAAACC CAGTGTGGCT GAGATCCAAA ATTGGGACAG TGAGTCAGGA ACCCATTTTG 
TTTTCTTGCT CTATTGCTGA GAACATTGCT TATGGTGCTG ATGACCCTTC CTCTGTGACC 
GCTGAGGAAA TCCAGAGAGT GGCTGAAGTG GCCAATGCAG TGGCCTTCAT CCGGAATTTC 
CCCCAAGGGT TCAACACTGT GGTTGGAGAA AAGGGTGTTC TCCTCTCAGG TGGGCAGAAA 
CAGCGGATTG CGATTGCCCG TGCTCTGCTA AAGAATCCCA AAATTCTTCT CCTAGATGAA 
GCAACCAGTG CGCTGGATGC CGAAAATGAG TACCTTGTTC AAGAAGCTCT AGATCGACTG 
ATGGATGGAA GAACGGTGTT AGTTATTGCC CATCGTCTGT CCACCATTAA GAATGCTAAT 
ATGGTTGCTG TTCTTGACCA AGGAAAAATT ACTGAATATG GAAAACATGA AGAGCTGCTT 
TCAAAACCAA ATGGGATATA CAGAAAACTA ATGAACAAAC AAAGTTTTAT TTCAGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011542437.1
CDS	1352..3031
Translation	MSSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSFISA

Target ORF information:

RefSeq Version	XM_011544135.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011544135.2

ORF Insert Sequence:

ATGTCCAGTG TTATCTCCAT GTCTGCCCCT TTCTTCCTGG GGAAGATCAT TGATGTCATC 
TATACCAACC CCACTGTGGA CTACAGCGAC AACCTGACCC GCCTCTGCCT AGGGCTCAGT 
GCCGTGTTTC TGTGTGGTGC TGCCGCCAAT GCCATTCGTG TCTACCTCAT GCAAACTTCA 
GGTCAGCGCA TTGTGAATAG GCTGAGAACT TCATTATTCT CCTCCATTCT GAGGCAGGAG 
GTTGCTTTCT TTGACAAGAC TCGCACAGGA GAATTGATTA ACCGCCTCTC ATCAGACACT 
GCACTCCTGG GGCGCTCAGT GACTGAAAAC CTCTCAGATG GGCTCAGGGC CGGGGCCCAG 
GCTTCCGTAG GCATCAGTAT GATGTTTTTT GTCTCACCTA ATCTGGCCAC CTTTGTTTTG 
AGCGTGGTGC CTCCAGTGTC AATCATTGCT GTAATTTATG GGCGATATCT ACGGAAACTG 
ACCAAAGTCA CTCAGGATTC CCTGGCACAA GCCACTCAGC TAGCTGAGGA ACGTATTGGA 
AATGTAAGAA CTGTTCGAGC TTTTGGGAAA GAAATGACTG AAATCGAGAA ATATGCCAGC 
AAAGTGGACC ATGTAATGCA GTTAGCAAGG AAAGAGGCAT TCGCCCGGGC TGGTTTCTTT 
GGAGCAACTG GGCTCTCCGG AAACCTGATC GTGCTTTCTG TCCTGTACAA AGGAGGGCTG 
CTGATGGGCA GTGCCCACAT GACCGTGGGT GAACTCTCTT CCTTCCTAAT GTATGCTTTC 
TGGGTTGGAA TAAGCATTGG AGGTCTGAGC TCTTTCTACT CGGAGCTGAT GAAAGGACTG 
GGTGCAGGGG GGCGCCTCTG GGAGCTCCTG GAGAGAGAGC CCAAGCTGCC TTTTAACGAG 
GGGGTCATCT TAAATGAGAA AAGCTTCCAG GGTGCTTTGG AGTTTAAGAA CGTGCATTTT 
GCCTATCCAG CTCGCCCAGA GGTGCCCATA TTTCAGGATT TCAGCCTTTC CATTCCGTCA 
GGATCTGTCA CGGCACTGGT TGGCCCAAGT GGTTCTGGCA AATCAACAGT GCTTTCACTC 
CTGCTGAGGT TGTACGACCC TGCTTCTGGA ACTATTAGTC TTGATGGCCA TGACATCCGT 
CAGCTAAACC CAGTGTGGCT GAGATCCAAA ATTGGGACAG TGAGTCAGGA ACCCATTTTG 
TTTTCTTGCT CTATTGCTGA GAACATTGCT TATGGTGCTG ATGACCCTTC CTCTGTGACC 
GCTGAGGAAA TCCAGAGAGT GGCTGAAGTG GCCAATGCAG TGGCCTTCAT CCGGAATTTC 
CCCCAAGGGT TCAACACTGT GGTTGGAGAA AAGGGTGTTC TCCTCTCAGG TGGGCAGAAA 
CAGCGGATTG CGATTGCCCG TGCTCTGCTA AAGAATCCCA AAATTCTTCT CCTAGATGAA 
GCAACCAGTG CGCTGGATGC CGAAAATGAG TACCTTGTTC AAGAAGCTCT AGATCGACTG 
ATGGATGGAA GAACGGTGTT AGTTATTGCC CATCGTCTGT CCACCATTAA GAATGCTAAT 
ATGGTTGCTG TTCTTGACCA AGGAAAAATT ACTGAATATG GAAAACATGA AGAGCTGCTT 
TCAAAACCAA ATGGGATATA CAGAAAACTA ATGAACAAAC AAAGTTTTAT TTCAGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ABCB10 ( XM_011544135.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011542437.1 Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu35007
Clone ID Related Accession (Same CDS sequence)	XM_011544135.2 , XM_011544135.3
Accession Version	XM_011544135.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1680bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ATP-binding cassette sub-family B member 10, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011544135.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGTG TTATCTCCAT GTCTGCCCCT TTCTTCCTGG GGAAGATCAT TGATGTCATC 
TATACCAACC CCACTGTGGA CTACAGCGAC AACCTGACCC GCCTCTGCCT AGGGCTCAGT 
GCCGTGTTTC TGTGTGGTGC TGCCGCCAAT GCCATTCGTG TCTACCTCAT GCAAACTTCA 
GGTCAGCGCA TTGTGAATAG GCTGAGAACT TCATTATTCT CCTCCATTCT GAGGCAGGAG 
GTTGCTTTCT TTGACAAGAC TCGCACAGGA GAATTGATTA ACCGCCTCTC ATCAGACACT 
GCACTCCTGG GGCGCTCAGT GACTGAAAAC CTCTCAGATG GGCTCAGGGC CGGGGCCCAG 
GCTTCCGTAG GCATCAGTAT GATGTTTTTT GTCTCACCTA ATCTGGCCAC CTTTGTTTTG 
AGCGTGGTGC CTCCAGTGTC AATCATTGCT GTAATTTATG GGCGATATCT ACGGAAACTG 
ACCAAAGTCA CTCAGGATTC CCTGGCACAA GCCACTCAGC TAGCTGAGGA ACGTATTGGA 
AATGTAAGAA CTGTTCGAGC TTTTGGGAAA GAAATGACTG AAATCGAGAA ATATGCCAGC 
AAAGTGGACC ATGTAATGCA GTTAGCAAGG AAAGAGGCAT TCGCCCGGGC TGGTTTCTTT 
GGAGCAACTG GGCTCTCCGG AAACCTGATC GTGCTTTCTG TCCTGTACAA AGGAGGGCTG 
CTGATGGGCA GTGCCCACAT GACCGTGGGT GAACTCTCTT CCTTCCTAAT GTATGCTTTC 
TGGGTTGGAA TAAGCATTGG AGGTCTGAGC TCTTTCTACT CGGAGCTGAT GAAAGGACTG 
GGTGCAGGGG GGCGCCTCTG GGAGCTCCTG GAGAGAGAGC CCAAGCTGCC TTTTAACGAG 
GGGGTCATCT TAAATGAGAA AAGCTTCCAG GGTGCTTTGG AGTTTAAGAA CGTGCATTTT 
GCCTATCCAG CTCGCCCAGA GGTGCCCATA TTTCAGGATT TCAGCCTTTC CATTCCGTCA 
GGATCTGTCA CGGCACTGGT TGGCCCAAGT GGTTCTGGCA AATCAACAGT GCTTTCACTC 
CTGCTGAGGT TGTACGACCC TGCTTCTGGA ACTATTAGTC TTGATGGCCA TGACATCCGT 
CAGCTAAACC CAGTGTGGCT GAGATCCAAA ATTGGGACAG TGAGTCAGGA ACCCATTTTG 
TTTTCTTGCT CTATTGCTGA GAACATTGCT TATGGTGCTG ATGACCCTTC CTCTGTGACC 
GCTGAGGAAA TCCAGAGAGT GGCTGAAGTG GCCAATGCAG TGGCCTTCAT CCGGAATTTC 
CCCCAAGGGT TCAACACTGT GGTTGGAGAA AAGGGTGTTC TCCTCTCAGG TGGGCAGAAA 
CAGCGGATTG CGATTGCCCG TGCTCTGCTA AAGAATCCCA AAATTCTTCT CCTAGATGAA 
GCAACCAGTG CGCTGGATGC CGAAAATGAG TACCTTGTTC AAGAAGCTCT AGATCGACTG 
ATGGATGGAA GAACGGTGTT AGTTATTGCC CATCGTCTGT CCACCATTAA GAATGCTAAT 
ATGGTTGCTG TTCTTGACCA AGGAAAAATT ACTGAATATG GAAAACATGA AGAGCTGCTT 
TCAAAACCAA ATGGGATATA CAGAAAACTA ATGAACAAAC AAAGTTTTAT TTCAGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011542437.1
CDS	1353..3032
Translation	MSSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSFISA

Target ORF information:

RefSeq Version	XM_011544135.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011544135.3

ORF Insert Sequence:

ATGTCCAGTG TTATCTCCAT GTCTGCCCCT TTCTTCCTGG GGAAGATCAT TGATGTCATC 
TATACCAACC CCACTGTGGA CTACAGCGAC AACCTGACCC GCCTCTGCCT AGGGCTCAGT 
GCCGTGTTTC TGTGTGGTGC TGCCGCCAAT GCCATTCGTG TCTACCTCAT GCAAACTTCA 
GGTCAGCGCA TTGTGAATAG GCTGAGAACT TCATTATTCT CCTCCATTCT GAGGCAGGAG 
GTTGCTTTCT TTGACAAGAC TCGCACAGGA GAATTGATTA ACCGCCTCTC ATCAGACACT 
GCACTCCTGG GGCGCTCAGT GACTGAAAAC CTCTCAGATG GGCTCAGGGC CGGGGCCCAG 
GCTTCCGTAG GCATCAGTAT GATGTTTTTT GTCTCACCTA ATCTGGCCAC CTTTGTTTTG 
AGCGTGGTGC CTCCAGTGTC AATCATTGCT GTAATTTATG GGCGATATCT ACGGAAACTG 
ACCAAAGTCA CTCAGGATTC CCTGGCACAA GCCACTCAGC TAGCTGAGGA ACGTATTGGA 
AATGTAAGAA CTGTTCGAGC TTTTGGGAAA GAAATGACTG AAATCGAGAA ATATGCCAGC 
AAAGTGGACC ATGTAATGCA GTTAGCAAGG AAAGAGGCAT TCGCCCGGGC TGGTTTCTTT 
GGAGCAACTG GGCTCTCCGG AAACCTGATC GTGCTTTCTG TCCTGTACAA AGGAGGGCTG 
CTGATGGGCA GTGCCCACAT GACCGTGGGT GAACTCTCTT CCTTCCTAAT GTATGCTTTC 
TGGGTTGGAA TAAGCATTGG AGGTCTGAGC TCTTTCTACT CGGAGCTGAT GAAAGGACTG 
GGTGCAGGGG GGCGCCTCTG GGAGCTCCTG GAGAGAGAGC CCAAGCTGCC TTTTAACGAG 
GGGGTCATCT TAAATGAGAA AAGCTTCCAG GGTGCTTTGG AGTTTAAGAA CGTGCATTTT 
GCCTATCCAG CTCGCCCAGA GGTGCCCATA TTTCAGGATT TCAGCCTTTC CATTCCGTCA 
GGATCTGTCA CGGCACTGGT TGGCCCAAGT GGTTCTGGCA AATCAACAGT GCTTTCACTC 
CTGCTGAGGT TGTACGACCC TGCTTCTGGA ACTATTAGTC TTGATGGCCA TGACATCCGT 
CAGCTAAACC CAGTGTGGCT GAGATCCAAA ATTGGGACAG TGAGTCAGGA ACCCATTTTG 
TTTTCTTGCT CTATTGCTGA GAACATTGCT TATGGTGCTG ATGACCCTTC CTCTGTGACC 
GCTGAGGAAA TCCAGAGAGT GGCTGAAGTG GCCAATGCAG TGGCCTTCAT CCGGAATTTC 
CCCCAAGGGT TCAACACTGT GGTTGGAGAA AAGGGTGTTC TCCTCTCAGG TGGGCAGAAA 
CAGCGGATTG CGATTGCCCG TGCTCTGCTA AAGAATCCCA AAATTCTTCT CCTAGATGAA 
GCAACCAGTG CGCTGGATGC CGAAAATGAG TACCTTGTTC AAGAAGCTCT AGATCGACTG 
ATGGATGGAA GAACGGTGTT AGTTATTGCC CATCGTCTGT CCACCATTAA GAATGCTAAT 
ATGGTTGCTG TTCTTGACCA AGGAAAAATT ACTGAATATG GAAAACATGA AGAGCTGCTT 
TCAAAACCAA ATGGGATATA CAGAAAACTA ATGAACAAAC AAAGTTTTAT TTCAGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ABCB10 ( XM_011544136.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011542438.1 Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu66200
Clone ID Related Accession (Same CDS sequence)	XM_011544136.2
Accession Version	XM_011544136.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1329bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ATP-binding cassette sub-family B member 10, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011544136.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCATTCG TGTCTACCTC ATGCAAACTT CAGTTTTTTG TCTCACCTAA TCTGGCCACC 
TTTGTTTTGA GCGTGGTGCC TCCAGTGTCA ATCATTGCTG TAATTTATGG GCGATATCTA 
CGGAAACTGA CCAAAGTCAC TCAGGATTCC CTGGCACAAG CCACTCAGCT AGCTGAGGAA 
CGTATTGGAA ATGTAAGAAC TGTTCGAGCT TTTGGGAAAG AAATGACTGA AATCGAGAAA 
TATGCCAGCA AAGTGGACCA TGTAATGCAG TTAGCAAGGA AAGAGGCATT CGCCCGGGCT 
GGTTTCTTTG GAGCAACTGG GCTCTCCGGA AACCTGATCG TGCTTTCTGT CCTGTACAAA 
GGAGGGCTGC TGATGGGCAG TGCCCACATG ACCGTGGGTG AACTCTCTTC CTTCCTAATG 
TATGCTTTCT GGGTTGGAAT AAGCATTGGA GGTCTGAGCT CTTTCTACTC GGAGCTGATG 
AAAGGACTGG GTGCAGGGGG GCGCCTCTGG GAGCTCCTGG AGAGAGAGCC CAAGCTGCCT 
TTTAACGAGG GGGTCATCTT AAATGAGAAA AGCTTCCAGG GTGCTTTGGA GTTTAAGAAC 
GTGCATTTTG CCTATCCAGC TCGCCCAGAG GTGCCCATAT TTCAGGATTT CAGCCTTTCC 
ATTCCGTCAG GATCTGTCAC GGCACTGGTT GGCCCAAGTG GTTCTGGCAA ATCAACAGTG 
CTTTCACTCC TGCTGAGGTT GTACGACCCT GCTTCTGGAA CTATTAGTCT TGATGGCCAT 
GACATCCGTC AGCTAAACCC AGTGTGGCTG AGATCCAAAA TTGGGACAGT GAGTCAGGAA 
CCCATTTTGT TTTCTTGCTC TATTGCTGAG AACATTGCTT ATGGTGCTGA TGACCCTTCC 
TCTGTGACCG CTGAGGAAAT CCAGAGAGTG GCTGAAGTGG CCAATGCAGT GGCCTTCATC 
CGGAATTTCC CCCAAGGGTT CAACACTGTG GTTGGAGAAA AGGGTGTTCT CCTCTCAGGT 
GGGCAGAAAC AGCGGATTGC GATTGCCCGT GCTCTGCTAA AGAATCCCAA AATTCTTCTC 
CTAGATGAAG CAACCAGTGC GCTGGATGCC GAAAATGAGT ACCTTGTTCA AGAAGCTCTA 
GATCGACTGA TGGATGGAAG AACGGTGTTA GTTATTGCCC ATCGTCTGTC CACCATTAAG 
AATGCTAATA TGGTTGCTGT TCTTGACCAA GGAAAAATTA CTGAATATGG AAAACATGAA 
GAGCTGCTTT CAAAACCAAA TGGGATATAC AGAAAACTAA TGAACAAACA AAGTTTTATT 
TCAGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011542438.1
CDS	169..1497
Translation	MPFVSTSCKLQFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSFISA

Target ORF information:

RefSeq Version	XM_011544136.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011544136.2

ORF Insert Sequence:

ATGCCATTCG TGTCTACCTC ATGCAAACTT CAGTTTTTTG TCTCACCTAA TCTGGCCACC 
TTTGTTTTGA GCGTGGTGCC TCCAGTGTCA ATCATTGCTG TAATTTATGG GCGATATCTA 
CGGAAACTGA CCAAAGTCAC TCAGGATTCC CTGGCACAAG CCACTCAGCT AGCTGAGGAA 
CGTATTGGAA ATGTAAGAAC TGTTCGAGCT TTTGGGAAAG AAATGACTGA AATCGAGAAA 
TATGCCAGCA AAGTGGACCA TGTAATGCAG TTAGCAAGGA AAGAGGCATT CGCCCGGGCT 
GGTTTCTTTG GAGCAACTGG GCTCTCCGGA AACCTGATCG TGCTTTCTGT CCTGTACAAA 
GGAGGGCTGC TGATGGGCAG TGCCCACATG ACCGTGGGTG AACTCTCTTC CTTCCTAATG 
TATGCTTTCT GGGTTGGAAT AAGCATTGGA GGTCTGAGCT CTTTCTACTC GGAGCTGATG 
AAAGGACTGG GTGCAGGGGG GCGCCTCTGG GAGCTCCTGG AGAGAGAGCC CAAGCTGCCT 
TTTAACGAGG GGGTCATCTT AAATGAGAAA AGCTTCCAGG GTGCTTTGGA GTTTAAGAAC 
GTGCATTTTG CCTATCCAGC TCGCCCAGAG GTGCCCATAT TTCAGGATTT CAGCCTTTCC 
ATTCCGTCAG GATCTGTCAC GGCACTGGTT GGCCCAAGTG GTTCTGGCAA ATCAACAGTG 
CTTTCACTCC TGCTGAGGTT GTACGACCCT GCTTCTGGAA CTATTAGTCT TGATGGCCAT 
GACATCCGTC AGCTAAACCC AGTGTGGCTG AGATCCAAAA TTGGGACAGT GAGTCAGGAA 
CCCATTTTGT TTTCTTGCTC TATTGCTGAG AACATTGCTT ATGGTGCTGA TGACCCTTCC 
TCTGTGACCG CTGAGGAAAT CCAGAGAGTG GCTGAAGTGG CCAATGCAGT GGCCTTCATC 
CGGAATTTCC CCCAAGGGTT CAACACTGTG GTTGGAGAAA AGGGTGTTCT CCTCTCAGGT 
GGGCAGAAAC AGCGGATTGC GATTGCCCGT GCTCTGCTAA AGAATCCCAA AATTCTTCTC 
CTAGATGAAG CAACCAGTGC GCTGGATGCC GAAAATGAGT ACCTTGTTCA AGAAGCTCTA 
GATCGACTGA TGGATGGAAG AACGGTGTTA GTTATTGCCC ATCGTCTGTC CACCATTAAG 
AATGCTAATA TGGTTGCTGT TCTTGACCAA GGAAAAATTA CTGAATATGG AAAACATGAA 
GAGCTGCTTT CAAAACCAAA TGGGATATAC AGAAAACTAA TGAACAAACA AAGTTTTATT 
TCAGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes.
The Journal of biological chemistry292(39)16284-16299(2017 09)
Seguin A,Takahashi-Makise N,Yien YY,Huston NC,Whitman JC,Musso G,Wallace JA,Bradley T,Bergonia HA,Kafina MD,Matsumoto M,Igarashi K,Phillips JD,Paw BH,Kaplan J,Ward DM

ABCB10 depletion reduces unfolded protein response in mitochondria.
Biochemical and biophysical research communications486(2)465-469(2017 04)
Yano M

Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
Human molecular genetics22(16)3381-93(2013 Aug)
Reiner AP,Hartiala J,Zeller T,Bis JC,Dupuis J,Fornage M,Baumert J,Kleber ME,Wild PS,Baldus S,Bielinski SJ,Fontes JD,Illig T,Keating BJ,Lange LA,Ojeda F,M?ller-Nurasyid M,Munzel TF,Psaty BM,Rice K,Rotter JI,Schnabel RB,Tang WH,Thorand B,Erdmann J,,Jacobs DR Jr,Wilson JG,Koenig W,Tracy RP,Blankenberg S,M?rz W,Gross MD,Benjamin EJ,Hazen SL,Allayee H

ATP-binding cassette B10 regulates early steps of heme synthesis.
Circulation research113(3)279-87(2013 Jul)
Bayeva M,Khechaduri A,Wu R,Burke MA,Wasserstrom JA,Singh N,Liesa M,Shirihai OS,Langer NB,Paw BH,Ardehali H

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.
Proceedings of the National Academy of Sciences of the United States of America110(24)9710-5(2013 Jun)
Shintre CA,Pike AC,Li Q,Kim JI,Barr AJ,Goubin S,Shrestha L,Yang J,Berridge G,Ross J,Stansfeld PJ,Sansom MS,Edwards AM,Bountra C,Marsden BD,von Delft F,Bullock AN,Gileadi O,Burgess-Brown NA,Carpenter EP

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ABCB10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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