EXOSC2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EXOSC2
Entrez Gene ID	23404
Full Name	exosome component 2
Synonyms	RRP4,Rrp4p,SHRF,hRrp4p,p7
General protein information	Preferred Names exosome component 2 Names exosome complex component RRP4 exosome complex exonuclease RRP4 homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4) homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease ribosomal RNA-processing protein 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q34.12
Disorder MIM:	602238
Disorder Html:	Short stature, hearing loss, retinitis pigmentosa, and distinctive facies, 617763 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_014285.6	NP_055100.2	exosome complex component RRP4 isoform 1
NM_001282708.1	NP_001269637.1	exosome complex component RRP4 isoform 2
NM_001282709.1	NP_001269638.1	exosome complex component RRP4 isoform 3
NM_014285.7	NP_055100.2	exosome complex component RRP4 isoform 1
XM_005272176.2	XP_005272233.1	exosome complex component RRP4 isoform X1
XM_017014558.1	XP_016870047.1	exosome complex component RRP4 isoform X1
XM_006717023.2	XP_006717086.1	exosome complex component RRP4 isoform X2

Pathways from BioSystems

Homologies

Homo sapiens (human)	EXOSC2	NP_055100.2
Canis lupus familiaris (dog)	EXOSC2	XP_005625290.1
Caenorhabditis elegans (roundworm)	exos-2	NP_500978.1
Schizosaccharomyces pombe (fission yeast)	SPAC2F7.14c	NP_592984.1
Neurospora crassa	NCU04009	XP_957624.2
Pan troglodytes (chimpanzee)	EXOSC2	XP_001166030.1
Gallus gallus (chicken)	EXOSC2	NP_001012816.2
Danio rerio (zebrafish)	exosc2	NP_001017572.2
Magnaporthe oryzae (rice blast fungus)	MGG_08100	XP_003715055.1
Oryza sativa (rice)	Os04g0520000	NP_001053332.1
	EXOSC2	XP_001106567.1
Xenopus tropicalis (tropical clawed frog)	exosc2	NP_001025658.1
Rattus norvegicus (Norway rat)	Exosc2	NP_001102422.1
Drosophila melanogaster (fruit fly)	Rrp4	NP_611807.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011211	XP_309432.3
Arabidopsis thaliana (thale cress)	RRP4	NP_171835.1
Bos taurus (cattle)	EXOSC2	NP_001040026.1
Mus musculus (house mouse)	Exosc2	NP_659135.1
Saccharomyces cerevisiae (baker's yeast)	RRP4	NP_011936.1
Kluyveromyces lactis	KLLA0E12739g	XP_454524.1
Eremothecium gossypii	AGOS_AAL034C	NP_982508.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Mutations in EXOSC2 are associated with a novel syndrome characterised by retinitis pigmentosa, progressive hearing loss, premature ageing, short stature, mild intellectual disability and distinctive gestalt.
Di Donato N, Neuhann T, Kahlert AK, Klink B, Hackmann K, Neuhann I, Novotna B, Schallner J, Krause C, Glass IA, Parnell SE, Benet-Pages A, Nissen AM, Berger W, Altm?ller J, Thiele H, Weber BH, Schrock E, Dobyns WB, Bier A, Rump A
Journal of medical genetics53(6)419-25(2016 Jun)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing.
Yoshikatsu Y, Ishida Y, Sudo H, Yuasa K, Tsuji A, Nagahama M
Biochemical and biophysical research communications464(3)780-6(2015 Aug)

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.
Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW
Cell144(3)353-63(2011 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The EXOSC2-associated phenotype shows only minimal overlap with the previously reported diseases associated with mutations.
Title: Mutations in EXOSC2 are associated with a novel syndrome characterised by retinitis pigmentosa, progressive hearing loss, premature ageing, short stature, mild intellectual disability and distinctive gestalt.

Knock-down of hRrp41p or hRrp4p but not PM/Scl-100 or PM/Scl-75 leads to codepletion of other subunits.
Title: Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways.

Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.
Title: Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.

The following EXOSC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EXOSC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01881	NM_014285.7 Latest version!	Homo sapiens exosome component 2 (EXOSC2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu43131	XM_005272176.2 Latest version!	Homo sapiens exosome component 2 (EXOSC2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu43131	XM_017014558.1 Latest version!	Homo sapiens exosome component 2 (EXOSC2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu43132	XM_006717023.2 Latest version!	Homo sapiens exosome component 2 (EXOSC2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu00156	NM_001282708.1 Latest version!	Homo sapiens exosome component 2 (EXOSC2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu01445	NM_001282709.1 Latest version!	Homo sapiens exosome component 2 (EXOSC2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu01881	NM_014285.6	Homo sapiens exosome component 2 (EXOSC2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EXOSC2 ( NM_014285.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_055100.2 Homo sapiens exosome component 2 (EXOSC2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01881
Clone ID Related Accession (Same CDS sequence)	NM_014285.6 , NM_014285.7
Accession Version	NM_014285.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-16
Organism	Homo sapiens(human)
Product	exosome complex component RRP4 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU934039.1, BC000747.2 and AL359092.14. On Sep 18, 2013 this sequence version replaced NM_014285.5. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.237644.1, SRR1660805.171413.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGCGATGG AGATGAGGCT TCCAGTGGCT CGCAAGCCTC TTAGCGAGAG ACTGGGCCGC 
GACACTAAGA AACATCTAGT GGTGCCGGGG GATACAATCA CTACGGACAC AGGATTCATG 
CGGGGCCATG GAACGTATAT GGGAGAAGAG AAGCTCATTG CATCTGTTGC TGGCTCTGTG 
GAGAGAGTAA ACAAGTTGAT CTGTGTGAAA GCTTTGAAAA CCAGATACAT TGGTGAAGTA 
GGAGACATCG TAGTGGGACG AATCACAGAG GTTCAACAGA AGAGGTGGAA GGTGGAGACC 
AACTCCAGGC TGGATTCGGT CTTGCTGCTC TCGTCCATGA ACCTTCCTGG AGGAGAGCTG 
AGGAGAAGAT CTGCAGAAGA TGAGCTTGCA ATGAGAGGTT TCTTACAGGA AGGGGACCTT 
ATCAGTGCTG AGGTCCAGGC AGTGTTCTCT GACGGAGCTG TCTCTTTGCA CACGAGGAGC 
CTGAAATATG GAAAACTAGG TCAGGGGGTT TTGGTCCAGG TTTCCCCCTC CCTGGTGAAA 
CGGCAGAAGA CCCACTTTCA TGATTTGCCA TGTGGTGCCT CAGTGATTCT CGGTAACAAC 
GGCTTCATCT GGATTTACCC AACACCTGAG CACAAAGAAG AGGAAGCAGG GGGCTTCATT 
GCAAACCTGG AGCCTGTCTC TCTTGCTGAT CGAGAGGTGA TATCCCGGCT TCGGAACTGC 
ATCATCTCGC TGGTAACTCA GAGGATGATG CTGTATGATA CCAGCATCCT GTACTGCTAT 
GAAGCATCCC TTCCACATCA GATCAAAGAC ATCTTAAAGC CAGAAATAAT GGAGGAGATT 
GTGATGGAAA CACGCCAGAG GCTTTTGGAA CAGGAGGGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055100.2
CDS	33..914
Translation	MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSVERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG

Target ORF information:

RefSeq Version	NM_014285.6
Organism	Homo sapiens(human)
Definition	Homo sapiens exosome component 2 (EXOSC2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014285.6

ORF Insert Sequence:

ATGGCGATGG AGATGAGGCT TCCAGTGGCT CGCAAGCCTC TTAGCGAGAG ACTGGGCCGC 
GACACTAAGA AACATCTAGT GGTGCCGGGG GATACAATCA CTACGGACAC AGGATTCATG 
CGGGGCCATG GAACGTATAT GGGAGAAGAG AAGCTCATTG CATCTGTTGC TGGCTCTGTG 
GAGAGAGTAA ACAAGTTGAT CTGTGTGAAA GCTTTGAAAA CCAGATACAT TGGTGAAGTA 
GGAGACATCG TAGTGGGACG AATCACAGAG GTTCAACAGA AGAGGTGGAA GGTGGAGACC 
AACTCCAGGC TGGATTCGGT CTTGCTGCTC TCGTCCATGA ACCTTCCTGG AGGAGAGCTG 
AGGAGAAGAT CTGCAGAAGA TGAGCTTGCA ATGAGAGGTT TCTTACAGGA AGGGGACCTT 
ATCAGTGCTG AGGTCCAGGC AGTGTTCTCT GACGGAGCTG TCTCTTTGCA CACGAGGAGC 
CTGAAATATG GAAAACTAGG TCAGGGGGTT TTGGTCCAGG TTTCCCCCTC CCTGGTGAAA 
CGGCAGAAGA CCCACTTTCA TGATTTGCCA TGTGGTGCCT CAGTGATTCT CGGTAACAAC 
GGCTTCATCT GGATTTACCC AACACCTGAG CACAAAGAAG AGGAAGCAGG GGGCTTCATT 
GCAAACCTGG AGCCTGTCTC TCTTGCTGAT CGAGAGGTGA TATCCCGGCT TCGGAACTGC 
ATCATCTCGC TGGTAACTCA GAGGATGATG CTGTATGATA CCAGCATCCT GTACTGCTAT 
GAAGCATCCC TTCCACATCA GATCAAAGAC ATCTTAAAGC CAGAAATAAT GGAGGAGATT 
GTGATGGAAA CACGCCAGAG GCTTTTGGAA CAGGAGGGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EXOSC2 ( NM_014285.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_055100.2 Homo sapiens exosome component 2 (EXOSC2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01881
Clone ID Related Accession (Same CDS sequence)	NM_014285.6 , NM_014285.7
Accession Version	NM_014285.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	exosome complex component RRP4 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU934039.1, BC000747.2 and AL359092.14. On Nov 22, 2018 this sequence version replaced NM_014285.6. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.38231.1, SRR1660803.108578.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000372358.10/ ENSP00000361433.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGATGG AGATGAGGCT TCCAGTGGCT CGCAAGCCTC TTAGCGAGAG ACTGGGCCGC 
GACACTAAGA AACATCTAGT GGTGCCGGGG GATACAATCA CTACGGACAC AGGATTCATG 
CGGGGCCATG GAACGTATAT GGGAGAAGAG AAGCTCATTG CATCTGTTGC TGGCTCTGTG 
GAGAGAGTAA ACAAGTTGAT CTGTGTGAAA GCTTTGAAAA CCAGATACAT TGGTGAAGTA 
GGAGACATCG TAGTGGGACG AATCACAGAG GTTCAACAGA AGAGGTGGAA GGTGGAGACC 
AACTCCAGGC TGGATTCGGT CTTGCTGCTC TCGTCCATGA ACCTTCCTGG AGGAGAGCTG 
AGGAGAAGAT CTGCAGAAGA TGAGCTTGCA ATGAGAGGTT TCTTACAGGA AGGGGACCTT 
ATCAGTGCTG AGGTCCAGGC AGTGTTCTCT GACGGAGCTG TCTCTTTGCA CACGAGGAGC 
CTGAAATATG GAAAACTAGG TCAGGGGGTT TTGGTCCAGG TTTCCCCCTC CCTGGTGAAA 
CGGCAGAAGA CCCACTTTCA TGATTTGCCA TGTGGTGCCT CAGTGATTCT CGGTAACAAC 
GGCTTCATCT GGATTTACCC AACACCTGAG CACAAAGAAG AGGAAGCAGG GGGCTTCATT 
GCAAACCTGG AGCCTGTCTC TCTTGCTGAT CGAGAGGTGA TATCCCGGCT TCGGAACTGC 
ATCATCTCGC TGGTAACTCA GAGGATGATG CTGTATGATA CCAGCATCCT GTACTGCTAT 
GAAGCATCCC TTCCACATCA GATCAAAGAC ATCTTAAAGC CAGAAATAAT GGAGGAGATT 
GTGATGGAAA CACGCCAGAG GCTTTTGGAA CAGGAGGGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055100.2
CDS	13..894
Translation	MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSVERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG

Target ORF information:

RefSeq Version	NM_014285.7
Organism	Homo sapiens(human)
Definition	Homo sapiens exosome component 2 (EXOSC2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014285.7

ORF Insert Sequence:

ATGGCGATGG AGATGAGGCT TCCAGTGGCT CGCAAGCCTC TTAGCGAGAG ACTGGGCCGC 
GACACTAAGA AACATCTAGT GGTGCCGGGG GATACAATCA CTACGGACAC AGGATTCATG 
CGGGGCCATG GAACGTATAT GGGAGAAGAG AAGCTCATTG CATCTGTTGC TGGCTCTGTG 
GAGAGAGTAA ACAAGTTGAT CTGTGTGAAA GCTTTGAAAA CCAGATACAT TGGTGAAGTA 
GGAGACATCG TAGTGGGACG AATCACAGAG GTTCAACAGA AGAGGTGGAA GGTGGAGACC 
AACTCCAGGC TGGATTCGGT CTTGCTGCTC TCGTCCATGA ACCTTCCTGG AGGAGAGCTG 
AGGAGAAGAT CTGCAGAAGA TGAGCTTGCA ATGAGAGGTT TCTTACAGGA AGGGGACCTT 
ATCAGTGCTG AGGTCCAGGC AGTGTTCTCT GACGGAGCTG TCTCTTTGCA CACGAGGAGC 
CTGAAATATG GAAAACTAGG TCAGGGGGTT TTGGTCCAGG TTTCCCCCTC CCTGGTGAAA 
CGGCAGAAGA CCCACTTTCA TGATTTGCCA TGTGGTGCCT CAGTGATTCT CGGTAACAAC 
GGCTTCATCT GGATTTACCC AACACCTGAG CACAAAGAAG AGGAAGCAGG GGGCTTCATT 
GCAAACCTGG AGCCTGTCTC TCTTGCTGAT CGAGAGGTGA TATCCCGGCT TCGGAACTGC 
ATCATCTCGC TGGTAACTCA GAGGATGATG CTGTATGATA CCAGCATCCT GTACTGCTAT 
GAAGCATCCC TTCCACATCA GATCAAAGAC ATCTTAAAGC CAGAAATAAT GGAGGAGATT 
GTGATGGAAA CACGCCAGAG GCTTTTGGAA CAGGAGGGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EXOSC2 ( XM_005272176.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005272233.1 Homo sapiens exosome component 2 (EXOSC2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu43131
Clone ID Related Accession (Same CDS sequence)	XM_005272176.2 , XM_017014558.1
Accession Version	XM_005272176.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	exosome complex component RRP4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005272176.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCTTC CTGGAGGAGA GCTGAGGAGA AGATCTGCAG AAGATGAGCT TGCAATGAGA 
GGTTTCTTAC AGGAAGGGGA CCTTATCAGT GCTGAGGTCC AGGCAGTGTT CTCTGACGGA 
GCTGTCTCTT TGCACACGAG GAGCCTGAAA TATGGAAAAC TAGGTCAGGG GGTTTTGGTC 
CAGGTTTCCC CCTCCCTGGT GAAACGGCAG AAGACCCACT TTCATGATTT GCCATGTGGT 
GCCTCAGTGA TTCTCGGTAA CAACGGCTTC ATCTGGATTT ACCCAACACC TGAGCACAAA 
GAAGAGGAAG CAGGGGGCTT CATTGCAAAC CTGGAGCCTG TCTCTCTTGC TGATCGAGAG 
GTGATATCCC GGCTTCGGAA CTGCATCATC TCGCTGGTAA CTCAGAGGAT GATGCTGTAT 
GATACCAGCA TCCTGTACTG CTATGAAGCA TCCCTTCCAC ATCAGATCAA AGACATCTTA 
AAGCCAGAAA TAATGGAGGA GATTGTGATG GAAACACGCC AGAGGCTTTT GGAACAGGAG 
GGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005272233.1
CDS	367..912
Translation	MNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG

Target ORF information:

RefSeq Version	XM_005272176.2
Organism	Homo sapiens(human)
Definition	Homo sapiens exosome component 2 (EXOSC2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005272176.2

ORF Insert Sequence:

ATGAACCTTC CTGGAGGAGA GCTGAGGAGA AGATCTGCAG AAGATGAGCT TGCAATGAGA 
GGTTTCTTAC AGGAAGGGGA CCTTATCAGT GCTGAGGTCC AGGCAGTGTT CTCTGACGGA 
GCTGTCTCTT TGCACACGAG GAGCCTGAAA TATGGAAAAC TAGGTCAGGG GGTTTTGGTC 
CAGGTTTCCC CCTCCCTGGT GAAACGGCAG AAGACCCACT TTCATGATTT GCCATGTGGT 
GCCTCAGTGA TTCTCGGTAA CAACGGCTTC ATCTGGATTT ACCCAACACC TGAGCACAAA 
GAAGAGGAAG CAGGGGGCTT CATTGCAAAC CTGGAGCCTG TCTCTCTTGC TGATCGAGAG 
GTGATATCCC GGCTTCGGAA CTGCATCATC TCGCTGGTAA CTCAGAGGAT GATGCTGTAT 
GATACCAGCA TCCTGTACTG CTATGAAGCA TCCCTTCCAC ATCAGATCAA AGACATCTTA 
AAGCCAGAAA TAATGGAGGA GATTGTGATG GAAACACGCC AGAGGCTTTT GGAACAGGAG 
GGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EXOSC2 ( XM_017014558.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016870047.1 Homo sapiens exosome component 2 (EXOSC2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu43131
Clone ID Related Accession (Same CDS sequence)	XM_005272176.2 , XM_017014558.1
Accession Version	XM_017014558.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	exosome complex component RRP4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCTTC CTGGAGGAGA GCTGAGGAGA AGATCTGCAG AAGATGAGCT TGCAATGAGA 
GGTTTCTTAC AGGAAGGGGA CCTTATCAGT GCTGAGGTCC AGGCAGTGTT CTCTGACGGA 
GCTGTCTCTT TGCACACGAG GAGCCTGAAA TATGGAAAAC TAGGTCAGGG GGTTTTGGTC 
CAGGTTTCCC CCTCCCTGGT GAAACGGCAG AAGACCCACT TTCATGATTT GCCATGTGGT 
GCCTCAGTGA TTCTCGGTAA CAACGGCTTC ATCTGGATTT ACCCAACACC TGAGCACAAA 
GAAGAGGAAG CAGGGGGCTT CATTGCAAAC CTGGAGCCTG TCTCTCTTGC TGATCGAGAG 
GTGATATCCC GGCTTCGGAA CTGCATCATC TCGCTGGTAA CTCAGAGGAT GATGCTGTAT 
GATACCAGCA TCCTGTACTG CTATGAAGCA TCCCTTCCAC ATCAGATCAA AGACATCTTA 
AAGCCAGAAA TAATGGAGGA GATTGTGATG GAAACACGCC AGAGGCTTTT GGAACAGGAG 
GGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016870047.1
CDS	901..1446
Translation	MNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG

Target ORF information:

RefSeq Version	XM_017014558.1
Organism	Homo sapiens(human)
Definition	Homo sapiens exosome component 2 (EXOSC2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017014558.1

ORF Insert Sequence:

ATGAACCTTC CTGGAGGAGA GCTGAGGAGA AGATCTGCAG AAGATGAGCT TGCAATGAGA 
GGTTTCTTAC AGGAAGGGGA CCTTATCAGT GCTGAGGTCC AGGCAGTGTT CTCTGACGGA 
GCTGTCTCTT TGCACACGAG GAGCCTGAAA TATGGAAAAC TAGGTCAGGG GGTTTTGGTC 
CAGGTTTCCC CCTCCCTGGT GAAACGGCAG AAGACCCACT TTCATGATTT GCCATGTGGT 
GCCTCAGTGA TTCTCGGTAA CAACGGCTTC ATCTGGATTT ACCCAACACC TGAGCACAAA 
GAAGAGGAAG CAGGGGGCTT CATTGCAAAC CTGGAGCCTG TCTCTCTTGC TGATCGAGAG 
GTGATATCCC GGCTTCGGAA CTGCATCATC TCGCTGGTAA CTCAGAGGAT GATGCTGTAT 
GATACCAGCA TCCTGTACTG CTATGAAGCA TCCCTTCCAC ATCAGATCAA AGACATCTTA 
AAGCCAGAAA TAATGGAGGA GATTGTGATG GAAACACGCC AGAGGCTTTT GGAACAGGAG 
GGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EXOSC2 ( XM_006717023.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006717086.1 Homo sapiens exosome component 2 (EXOSC2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu43132
Clone ID Related Accession (Same CDS sequence)	XM_006717023.2
Accession Version	XM_006717023.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	exosome complex component RRP4 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006717023.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGAGGTT TCTTACAGGA AGGGGACCTT ATCAGTGCTG AGGTCCAGGC AGTGTTCTCT 
GACGGAGCTG TCTCTTTGCA CACGAGGAGC CTGAAATATG GAAAACTAGG TCAGGGGGTT 
TTGGTCCAGG TTTCCCCCTC CCTGGTGAAA CGGCAGAAGA CCCACTTTCA TGATTTGCCA 
TGTGGTGCCT CAGTGATTCT CGGTAACAAC GGCTTCATCT GGATTTACCC AACACCTGAG 
CACAAAGAAG AGGAAGCAGG GGGCTTCATT GCAAACCTGG AGCCTGTCTC TCTTGCTGAT 
CGAGAGGTGA TATCCCGGCT TCGGAACTGC ATCATCTCGC TGGTAACTCA GAGGATGATG 
CTGTATGATA CCAGCATCCT GTACTGCTAT GAAGCATCCC TTCCACATCA GATCAAAGAC 
ATCTTAAAGC CAGAAATAAT GGAGGAGATT GTGATGGAAA CACGCCAGAG GCTTTTGGAA 
CAGGAGGGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006717086.1
CDS	331..822
Translation	MRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG

Target ORF information:

RefSeq Version	XM_006717023.2
Organism	Homo sapiens(human)
Definition	Homo sapiens exosome component 2 (EXOSC2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006717023.2

ORF Insert Sequence:

ATGAGAGGTT TCTTACAGGA AGGGGACCTT ATCAGTGCTG AGGTCCAGGC AGTGTTCTCT 
GACGGAGCTG TCTCTTTGCA CACGAGGAGC CTGAAATATG GAAAACTAGG TCAGGGGGTT 
TTGGTCCAGG TTTCCCCCTC CCTGGTGAAA CGGCAGAAGA CCCACTTTCA TGATTTGCCA 
TGTGGTGCCT CAGTGATTCT CGGTAACAAC GGCTTCATCT GGATTTACCC AACACCTGAG 
CACAAAGAAG AGGAAGCAGG GGGCTTCATT GCAAACCTGG AGCCTGTCTC TCTTGCTGAT 
CGAGAGGTGA TATCCCGGCT TCGGAACTGC ATCATCTCGC TGGTAACTCA GAGGATGATG 
CTGTATGATA CCAGCATCCT GTACTGCTAT GAAGCATCCC TTCCACATCA GATCAAAGAC 
ATCTTAAAGC CAGAAATAAT GGAGGAGATT GTGATGGAAA CACGCCAGAG GCTTTTGGAA 
CAGGAGGGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EXOSC2 ( NM_001282708.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269637.1 Homo sapiens exosome component 2 (EXOSC2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu00156
Clone ID Related Accession (Same CDS sequence)	NM_001282708.1
Accession Version	NM_001282708.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	exosome complex component RRP4 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU934039.1, AK296605.1 and AL359092.14. On Sep 18, 2013 this sequence version replaced XM_005272174.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.487020.1, SRR1660803.343295.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGGCGATGG AGATGAGGCT TCCAGTGGCT CGCAAGCCTC TTAGCGAGAG ACTGGGCCGC 
GACACTAAGA AACATCTAGT GGTGCCGGGG GATACAATCA CTACGGACAC AGGATTCATG 
CGGGGCCATG GAACGTATAT GGGAGAAGAG AAGCTCATTG CATCTGTTGC TGGCTCTGTG 
GAGAGAGTAA ACAAGTTGAT CTGTGTGAAA GCTTTGAAAA CCAGATACAT TGGTGAAGTA 
GGAGACATCG TAGTGGGACG AATCACAGAG GTTCAACAGA AGAGGTGGAA GGTGGAGACC 
AACTCCAGGC TGGATTCGGT CTTGCTGCTC TCGTCCATGA ACCTTCCTGG AGGAGAGCTG 
AGGAGAAGAT CTGCAGAAGA TGAGCTTGCA ATGAGAGGTT TCTTACAGGA AGGGGACCTT 
ATCAGTGGGG TTTTGGTCCA GGTTTCCCCC TCCCTGGTGA AACGGCAGAA GACCCACTTT 
CATGATTTGC CATGTGGTGC CTCAGTGATT CTCGGTAACA ACGGCTTCAT CTGGATTTAC 
CCAACACCTG AGCACAAAGA AGAGGAAGCA GGGGGCTTCA TTGCAAACCT GGAGCCTGTC 
TCTCTTGCTG ATCGAGAGGT GATATCCCGG CTTCGGAACT GCATCATCTC GCTGGTAACT 
CAGAGGATGA TGCTGTATGA TACCAGCATC CTGTACTGCT ATGAAGCATC CCTTCCACAT 
CAGATCAAAG ACATCTTAAA GCCAGAAATA ATGGAGGAGA TTGTGATGGA AACACGCCAG 
AGGCTTTTGG AACAGGAGGG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269637.1
CDS	33..836
Translation	MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSVERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG

Target ORF information:

RefSeq Version	NM_001282708.1
Organism	Homo sapiens(human)
Definition	Homo sapiens exosome component 2 (EXOSC2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282708.1

ORF Insert Sequence:

ATGGCGATGG AGATGAGGCT TCCAGTGGCT CGCAAGCCTC TTAGCGAGAG ACTGGGCCGC 
GACACTAAGA AACATCTAGT GGTGCCGGGG GATACAATCA CTACGGACAC AGGATTCATG 
CGGGGCCATG GAACGTATAT GGGAGAAGAG AAGCTCATTG CATCTGTTGC TGGCTCTGTG 
GAGAGAGTAA ACAAGTTGAT CTGTGTGAAA GCTTTGAAAA CCAGATACAT TGGTGAAGTA 
GGAGACATCG TAGTGGGACG AATCACAGAG GTTCAACAGA AGAGGTGGAA GGTGGAGACC 
AACTCCAGGC TGGATTCGGT CTTGCTGCTC TCGTCCATGA ACCTTCCTGG AGGAGAGCTG 
AGGAGAAGAT CTGCAGAAGA TGAGCTTGCA ATGAGAGGTT TCTTACAGGA AGGGGACCTT 
ATCAGTGGGG TTTTGGTCCA GGTTTCCCCC TCCCTGGTGA AACGGCAGAA GACCCACTTT 
CATGATTTGC CATGTGGTGC CTCAGTGATT CTCGGTAACA ACGGCTTCAT CTGGATTTAC 
CCAACACCTG AGCACAAAGA AGAGGAAGCA GGGGGCTTCA TTGCAAACCT GGAGCCTGTC 
TCTCTTGCTG ATCGAGAGGT GATATCCCGG CTTCGGAACT GCATCATCTC GCTGGTAACT 
CAGAGGATGA TGCTGTATGA TACCAGCATC CTGTACTGCT ATGAAGCATC CCTTCCACAT 
CAGATCAAAG ACATCTTAAA GCCAGAAATA ATGGAGGAGA TTGTGATGGA AACACGCCAG 
AGGCTTTTGG AACAGGAGGG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EXOSC2 ( NM_001282709.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269638.1 Homo sapiens exosome component 2 (EXOSC2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu01445
Clone ID Related Accession (Same CDS sequence)	NM_001282709.1
Accession Version	NM_001282709.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	exosome complex component RRP4 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU934039.1, DA813307.1, AL573310.3 and AL359092.14. On Sep 18, 2013 this sequence version replaced XM_005272175.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 3 which is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.62954.1, SRR1660807.86716.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END##

ATGGCGATGG AGATGAGGCT TCCAGTGGCT CGCAAGCCTC TTAGCGAGAG ACTGGGCCGC 
GACACTAAGA AACATCTAGT GGTGCCGGGG GATACAATCA CTACGGACAC AGGATTCATG 
CGGGGCCATG GAACGTATAT GGGAGAAGAG AAGCTCATTG CATCTGTTGC TGGCTCTGTG 
GAGAGAGTAA ACAAGTTGAT CTGTGTGAAA GCTTTGAAAA CCAGATACAT TGGTGAAGTA 
GGAGACATCG TAGTGGGACG AATCACAGAG AGGAGAAGAT CTGCAGAAGA TGAGCTTGCA 
ATGAGAGGTT TCTTACAGGA AGGGGACCTT ATCAGTGCTG AGGTCCAGGC AGTGTTCTCT 
GACGGAGCTG TCTCTTTGCA CACGAGGAGC CTGAAATATG GAAAACTAGG TCAGGGGGTT 
TTGGTCCAGG TTTCCCCCTC CCTGGTGAAA CGGCAGAAGA CCCACTTTCA TGATTTGCCA 
TGTGGTGCCT CAGTGATTCT CGGTAACAAC GGCTTCATCT GGATTTACCC AACACCTGAG 
CACAAAGAAG AGGAAGCAGG GGGCTTCATT GCAAACCTGG AGCCTGTCTC TCTTGCTGAT 
CGAGAGGTGA TATCCCGGCT TCGGAACTGC ATCATCTCGC TGGTAACTCA GAGGATGATG 
CTGTATGATA CCAGCATCCT GTACTGCTAT GAAGCATCCC TTCCACATCA GATCAAAGAC 
ATCTTAAAGC CAGAAATAAT GGAGGAGATT GTGATGGAAA CACGCCAGAG GCTTTTGGAA 
CAGGAGGGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269638.1
CDS	33..824
Translation	MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSVERVNKLICVKALKTRYIGEVGDIVVGRITERRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG

Target ORF information:

RefSeq Version	NM_001282709.1
Organism	Homo sapiens(human)
Definition	Homo sapiens exosome component 2 (EXOSC2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282709.1

ORF Insert Sequence:

ATGGCGATGG AGATGAGGCT TCCAGTGGCT CGCAAGCCTC TTAGCGAGAG ACTGGGCCGC 
GACACTAAGA AACATCTAGT GGTGCCGGGG GATACAATCA CTACGGACAC AGGATTCATG 
CGGGGCCATG GAACGTATAT GGGAGAAGAG AAGCTCATTG CATCTGTTGC TGGCTCTGTG 
GAGAGAGTAA ACAAGTTGAT CTGTGTGAAA GCTTTGAAAA CCAGATACAT TGGTGAAGTA 
GGAGACATCG TAGTGGGACG AATCACAGAG AGGAGAAGAT CTGCAGAAGA TGAGCTTGCA 
ATGAGAGGTT TCTTACAGGA AGGGGACCTT ATCAGTGCTG AGGTCCAGGC AGTGTTCTCT 
GACGGAGCTG TCTCTTTGCA CACGAGGAGC CTGAAATATG GAAAACTAGG TCAGGGGGTT 
TTGGTCCAGG TTTCCCCCTC CCTGGTGAAA CGGCAGAAGA CCCACTTTCA TGATTTGCCA 
TGTGGTGCCT CAGTGATTCT CGGTAACAAC GGCTTCATCT GGATTTACCC AACACCTGAG 
CACAAAGAAG AGGAAGCAGG GGGCTTCATT GCAAACCTGG AGCCTGTCTC TCTTGCTGAT 
CGAGAGGTGA TATCCCGGCT TCGGAACTGC ATCATCTCGC TGGTAACTCA GAGGATGATG 
CTGTATGATA CCAGCATCCT GTACTGCTAT GAAGCATCCC TTCCACATCA GATCAAAGAC 
ATCTTAAAGC CAGAAATAAT GGAGGAGATT GTGATGGAAA CACGCCAGAG GCTTTTGGAA 
CAGGAGGGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Mutations in EXOSC2 are associated with a novel syndrome characterised by retinitis pigmentosa, progressive hearing loss, premature ageing, short stature, mild intellectual disability and distinctive gestalt.
Journal of medical genetics53(6)419-25(2016 Jun)
Di Donato N,Neuhann T,Kahlert AK,Klink B,Hackmann K,Neuhann I,Novotna B,Schallner J,Krause C,Glass IA,Parnell SE,Benet-Pages A,Nissen AM,Berger W,Altm?ller J,Thiele H,Weber BH,Schrock E,Dobyns WB,Bier A,Rump A

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing.
Biochemical and biophysical research communications464(3)780-6(2015 Aug)
Yoshikatsu Y,Ishida Y,Sudo H,Yuasa K,Tsuji A,Nagahama M

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.
Cell144(3)353-63(2011 Feb)
Basu U,Meng FL,Keim C,Grinstein V,Pefanis E,Eccleston J,Zhang T,Myers D,Wasserman CR,Wesemann DR,Januszyk K,Gregory RI,Deng H,Lima CD,Alt FW

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

EXOSC2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報