TTLL12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TTLL12
Entrez Gene ID	23170
Full Name	tubulin tyrosine ligase like 12
Synonyms	dJ526I14.2
General protein information	Preferred Names tubulin tyrosine ligase like 12 Names tubulin--tyrosine ligase-like protein 12 tubulin tyrosine ligase-like family, member 12
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_015140.3	NP_055955.1	tubulin--tyrosine ligase-like protein 12
NM_015140.4	NP_055955.1	tubulin--tyrosine ligase-like protein 12

Pathways from BioSystems

Homologies

	TTLL12	XP_001104848.2
Mus musculus (house mouse)	Ttll12	NP_898838.2
Gallus gallus (chicken)	TTLL12	NP_001012558.1
Xenopus tropicalis (tropical clawed frog)	LOC100486512	XP_002944634.2
Pan troglodytes (chimpanzee)	TTLL12	XP_001171890.1
Bos taurus (cattle)	TTLL12	NP_001068978.1
Arabidopsis thaliana (thale cress)	AT1G77550	NP_177879.3
Homo sapiens (human)	TTLL12	NP_055955.1
Rattus norvegicus (Norway rat)	Ttll12	NP_001129394.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004284	XP_313558.5
Caenorhabditis elegans (roundworm)	ttll-12	NP_495990.1
Canis lupus familiaris (dog)	TTLL12	XP_531703.4
Danio rerio (zebrafish)	ttll12	NP_956546.1
Drosophila melanogaster (fruit fly)	CG1550	NP_610325.1
Oryza sativa (rice)	Os03g0179000	NP_001049155.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS.
Ju LG, Zhu Y, Lei PJ, Yan D, Zhu K, Wang X, Li QL, Li XJ, Chen JW, Li LY, Wu M
Journal of immunology (Baltimore, Md. : 1950)198(3)1274-1284(2017 Feb)

Identification of a novel transcript isoform of the TTLL12 gene in human cancers.
Wen R, Xiao Y, Zhang Y, Yang M, Lin Y, Tang J
Oncology reports36(6)3172-3180(2016 Dec)

Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH).
K?hnisch J, Thiering E, Heitm?ller D, Tiesler CM, Grallert H, Heinrich-Weltzien R, Hickel R, Heinrich J, ,
Clinical oral investigations18(2)677-82(2014)

Tubulin tyrosine ligase like 12, a TTLL family member with SET- and TTL-like domains and roles in histone and tubulin modifications and mitosis.
Brants J, Semenchenko K, Wasylyk C, Robert A, Carles A, Zambrano A, Pradeau-Aubreton K, Birck C, Schalken JA, Poch O, de Mey J, Wasylyk B
PloS one7(12)e51258(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TTLL12 as a negative regulator of RNA-virus-induced type I IFN expression by inhibiting the interaction of VISA with other proteins.
Title: TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS.

A new TTLL12 isoform may be of importance for proper maintenance of lung cancer cells.
Title: Identification of a novel transcript isoform of the TTLL12 gene in human cancers.

results suggest that hTTLL12 has non-catalytic functions related to tubulin and histone modification, which could be linked to its effects on mitosis and chromosome number stability
Title: Tubulin tyrosine ligase like 12, a TTLL family member with SET- and TTL-like domains and roles in histone and tubulin modifications and mitosis.

Results raise the possibility that TTLL12 could contribute to tumorigenesis through effects on the cytoskeleton, tubulin modification and chromosome number stability.
Title: Tubulin tyrosine ligase like 12 links to prostate cancer through tubulin posttranslational modification and chromosome ploidy.

The following TTLL12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TTLL12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26655	NM_015140.4 Latest version!	Homo sapiens tubulin tyrosine ligase like 12 (TTLL12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu26655	NM_015140.3	Homo sapiens tubulin tyrosine ligase like 12 (TTLL12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TTLL12 ( NM_015140.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055955.1 Homo sapiens tubulin tyrosine ligase like 12 (TTLL12), mRNA.

Price & Availability↑

CloneID	OHu26655
Clone ID Related Accession (Same CDS sequence)	NM_015140.3 , NM_015140.4
Accession Version	NM_015140.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1935bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	tubulin--tyrosine ligase-like protein 12
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX411143.2, BC001070.2 and BE785973.1. On May 13, 2010 this sequence version replaced NM_015140.2. ##Evidence-Data-START## Transcript exon combination :: BC001070.2, SRR1803615.158732.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267761 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGCCG AGCGGGGTCC CGAGCGCCGG CCTGCGGAGC GTAGCAGCCC GGGCCAGACG 
CCGGAGGAGG GCGCGCAGGC CTTGGCCGAG TTCGCGGCGC TGCACGGCCC GGCGCTGCGC 
GCTTCGGGGG TCCCCGAACG TTACTGGGGC CGCCTCCTGC ACAAGCTGGA GCACGAGGTT 
TTCGACGCTG GGGAAGTGTT TGGGATCATG CAAGTGGAGG AGGTAGAAGA GGAGGAGGAC 
GAGGCAGCCC GGGAGGTGCG GAAGCAGCAG CCCAACCCGG GGAACGAGCT GTGCTACAAG 
GTCATCGTGA CCAGGGAGAG CGGGCTCCAG GCAGCCCACC CCAACAGCAT CTTCCTCATC 
GACCACGCCT GGACGTGCCG TGTGGAGCAC GCGCGCCAGC AGCTGCAGCA GGTGCCCGGG 
CTGCTGCACC GCATGGCCAA CCTGATGGGC ATTGAGTTCC ACGGTGAGCT GCCCAGTACA 
GAGGCTGTGG CCCTGGTGCT GGAGGAGATG TGGAAGTTCA ACCAGACCTA CCAGCTGGCC 
CATGGGACAG CTGAGGAGAA GATGCCGGTG TGGTATATCA TGGACGAGTT CGGTTCGCGG 
ATCCAGCACG CGGACGTGCC CAGCTTCGCC ACGGCACCCT TCTTCTACAT GCCGCAGCAG 
GTGGCCTACA CGCTGCTGTG GCCCCTGAGG GACCTGGACA CTGGCGAGGA GGTGACCCGA 
GACTTTGCCT ACGGAGAGAC GGACCCCCTG ATCCGGAAGT GCATGCTGCT GCCCTGGGCC 
CCCACCGACA TGCTGGACCT CAGCTCTTGC ACACCCGAGC CGCCCGCCGA GCACTACCAG 
GCCATTCTGG AGGAAAACAA GGAGAAGCTG CCACTTGACA TCAACCCCGT GGTGCACCCC 
CACGGCCACA TCTTCAAGGT CTACACGGAC GTGCAGCAGG TGGCCAGCAG CCTCACCCAC 
CCGCGCTTCA CCCTCACCCA GAGTGAGGCG GACGCCGACA TCCTCTTCAA CTTCTCACAC 
TTCAAGGACT ACAGGAAACT CAGCCAGGAG AGGCCAGGCG TGCTGCTGAA CCAGTTCCCC 
TGCGAGAACC TGCTGACTGT CAAGGACTGC CTGGCCTCCA TCGCGCGCCG GGCAGGTGGC 
CCCGAGGGCC CACCCTGGCT GCCCCGAACC TTCAACCTGC GCACTGAGCT GCCCCAGTTT 
GTCAGCTACT TCCAGCAGCG GGAAAGGTGG GGCGAGGACA ACCACTGGAT CTGCAAGCCC 
TGGAACCTGG CGCGCAGCCT GGACACCCAC GTCACCAAGA GCCTGCACAG CATCATCCGG 
CACCGAGAGA GCACCCCCAA GGTTGTGTCC AAGTACATCG AAAGTCCCGT GTTGTTCCTT 
CGAGAAGACG TGGGAAAGGT CAAGTTCGAC ATCCGCTACA TCGTGCTGCT GCGGTCAGTG 
AGGCCCCTAC GGTTGTTCGT GTATGATGTG TTCTGGCTGC GGTTCTCCAA CCGGGCCTTT 
GCACTCAACG ACCTGGATGA CTACGAGAAG CACTTCACGG TCATGAACTA TGACCCGGAT 
GTGGTGCTGA AGCAGGTGCA CTGTGAAGAG TTCATCCCCG AGTTTGAGAA GCAATACCCA 
GAATTTCCCT GGACGGACGT CCAGGCTGAG ATCTTCCGGG CCTTCACGGA GCTGTTCCAG 
GTGGCCTGTG CCAAGCCACC ACCCCTGGGC CTCTGCGACT ACCCCTCATC CCGGGCCATG 
TATGCCGTCG ACCTCATGCT GAAGTGGGAC AACGGCCCAG ATGGAAGGCG GGTGATGCAG 
CCGCAGATCC TGGAGGTGAA CTTCAACCCC GACTGTGAGC GAGCCTGCAG GTACCACCCC 
ACCTTCTTCA ACGACGTCTT CAGCACCTTG TTTCTGGACC AGCCCGGTGG CTGCCACGTT 
ACCTGCCTTG TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055955.1
CDS	63..1997
Translation	MEAERGPERRPAERSSPGQTPEEGAQALAEFAALHGPALRASGVPERYWGRLLHKLEHEVFDAGEVFGIMQVEEVEEEEDEAAREVRKQQPNPGNELCYKVIVTRESGLQAAHPNSIFLIDHAWTCRVEHARQQLQQVPGLLHRMANLMGIEFHGELPSTEAVALVLEEMWKFNQTYQLAHGTAEEKMPVWYIMDEFGSRIQHADVPSFATAPFFYMPQQVAYTLLWPLRDLDTGEEVTRDFAYGETDPLIRKCMLLPWAPTDMLDLSSCTPEPPAEHYQAILEENKEKLPLDINPVVHPHGHIFKVYTDVQQVASSLTHPRFTLTQSEADADILFNFSHFKDYRKLSQERPGVLLNQFPCENLLTVKDCLASIARRAGGPEGPPWLPRTFNLRTELPQFVSYFQQRERWGEDNHWICKPWNLARSLDTHVTKSLHSIIRHRESTPKVVSKYIESPVLFLREDVGKVKFDIRYIVLLRSVRPLRLFVYDVFWLRFSNRAFALNDLDDYEKHFTVMNYDPDVVLKQVHCEEFIPEFEKQYPEFPWTDVQAEIFRAFTELFQVACAKPPPLGLCDYPSSRAMYAVDLMLKWDNGPDGRRVMQPQILEVNFNPDCERACRYHPTFFNDVFSTLFLDQPGGCHVTCLV

Target ORF information:

RefSeq Version	NM_015140.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin tyrosine ligase like 12 (TTLL12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015140.3

ORF Insert Sequence:

ATGGAGGCCG AGCGGGGTCC CGAGCGCCGG CCTGCGGAGC GTAGCAGCCC GGGCCAGACG 
CCGGAGGAGG GCGCGCAGGC CTTGGCCGAG TTCGCGGCGC TGCACGGCCC GGCGCTGCGC 
GCTTCGGGGG TCCCCGAACG TTACTGGGGC CGCCTCCTGC ACAAGCTGGA GCACGAGGTT 
TTCGACGCTG GGGAAGTGTT TGGGATCATG CAAGTGGAGG AGGTAGAAGA GGAGGAGGAC 
GAGGCAGCCC GGGAGGTGCG GAAGCAGCAG CCCAACCCGG GGAACGAGCT GTGCTACAAG 
GTCATCGTGA CCAGGGAGAG CGGGCTCCAG GCAGCCCACC CCAACAGCAT CTTCCTCATC 
GACCACGCCT GGACGTGCCG TGTGGAGCAC GCGCGCCAGC AGCTGCAGCA GGTGCCCGGG 
CTGCTGCACC GCATGGCCAA CCTGATGGGC ATTGAGTTCC ACGGTGAGCT GCCCAGTACA 
GAGGCTGTGG CCCTGGTGCT GGAGGAGATG TGGAAGTTCA ACCAGACCTA CCAGCTGGCC 
CATGGGACAG CTGAGGAGAA GATGCCGGTG TGGTATATCA TGGACGAGTT CGGTTCGCGG 
ATCCAGCACG CGGACGTGCC CAGCTTCGCC ACGGCACCCT TCTTCTACAT GCCGCAGCAG 
GTGGCCTACA CGCTGCTGTG GCCCCTGAGG GACCTGGACA CTGGCGAGGA GGTGACCCGA 
GACTTTGCCT ACGGAGAGAC GGACCCCCTG ATCCGGAAGT GCATGCTGCT GCCCTGGGCC 
CCCACCGACA TGCTGGACCT CAGCTCTTGC ACACCCGAGC CGCCCGCCGA GCACTACCAG 
GCCATTCTGG AGGAAAACAA GGAGAAGCTG CCACTTGACA TCAACCCCGT GGTGCACCCC 
CACGGCCACA TCTTCAAGGT CTACACGGAC GTGCAGCAGG TGGCCAGCAG CCTCACCCAC 
CCGCGCTTCA CCCTCACCCA GAGTGAGGCG GACGCCGACA TCCTCTTCAA CTTCTCACAC 
TTCAAGGACT ACAGGAAACT CAGCCAGGAG AGGCCAGGCG TGCTGCTGAA CCAGTTCCCC 
TGCGAGAACC TGCTGACTGT CAAGGACTGC CTGGCCTCCA TCGCGCGCCG GGCAGGTGGC 
CCCGAGGGCC CACCCTGGCT GCCCCGAACC TTCAACCTGC GCACTGAGCT GCCCCAGTTT 
GTCAGCTACT TCCAGCAGCG GGAAAGGTGG GGCGAGGACA ACCACTGGAT CTGCAAGCCC 
TGGAACCTGG CGCGCAGCCT GGACACCCAC GTCACCAAGA GCCTGCACAG CATCATCCGG 
CACCGAGAGA GCACCCCCAA GGTTGTGTCC AAGTACATCG AAAGTCCCGT GTTGTTCCTT 
CGAGAAGACG TGGGAAAGGT CAAGTTCGAC ATCCGCTACA TCGTGCTGCT GCGGTCAGTG 
AGGCCCCTAC GGTTGTTCGT GTATGATGTG TTCTGGCTGC GGTTCTCCAA CCGGGCCTTT 
GCACTCAACG ACCTGGATGA CTACGAGAAG CACTTCACGG TCATGAACTA TGACCCGGAT 
GTGGTGCTGA AGCAGGTGCA CTGTGAAGAG TTCATCCCCG AGTTTGAGAA GCAATACCCA 
GAATTTCCCT GGACGGACGT CCAGGCTGAG ATCTTCCGGG CCTTCACGGA GCTGTTCCAG 
GTGGCCTGTG CCAAGCCACC ACCCCTGGGC CTCTGCGACT ACCCCTCATC CCGGGCCATG 
TATGCCGTCG ACCTCATGCT GAAGTGGGAC AACGGCCCAG ATGGAAGGCG GGTGATGCAG 
CCGCAGATCC TGGAGGTGAA CTTCAACCCC GACTGTGAGC GAGCCTGCAG GTACCACCCC 
ACCTTCTTCA ACGACGTCTT CAGCACCTTG TTTCTGGACC AGCCCGGTGG CTGCCACGTT 
ACCTGCCTTG TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TTLL12 ( NM_015140.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055955.1 Homo sapiens tubulin tyrosine ligase like 12 (TTLL12), mRNA.

Price & Availability↑

CloneID	OHu26655
Clone ID Related Accession (Same CDS sequence)	NM_015140.3 , NM_015140.4
Accession Version	NM_015140.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1935bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	tubulin--tyrosine ligase-like protein 12
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from Z82214.23, BX411143.2, BC001070.2 and BE785973.1. On Nov 22, 2018 this sequence version replaced NM_015140.3. ##Evidence-Data-START## Transcript exon combination :: BC001070.2, SRR1803615.158732.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267761 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216129.7/ ENSP00000216129.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGCCG AGCGGGGTCC CGAGCGCCGG CCTGCGGAGC GTAGCAGCCC GGGCCAGACG 
CCGGAGGAGG GCGCGCAGGC CTTGGCCGAG TTCGCGGCGC TGCACGGCCC GGCGCTGCGC 
GCTTCGGGGG TCCCCGAACG TTACTGGGGC CGCCTCCTGC ACAAGCTGGA GCACGAGGTT 
TTCGACGCTG GGGAAGTGTT TGGGATCATG CAAGTGGAGG AGGTAGAAGA GGAGGAGGAC 
GAGGCAGCCC GGGAGGTGCG GAAGCAGCAG CCCAACCCGG GGAACGAGCT GTGCTACAAG 
GTCATCGTGA CCAGGGAGAG CGGGCTCCAG GCAGCCCACC CCAACAGCAT CTTCCTCATC 
GACCACGCCT GGACGTGCCG TGTGGAGCAC GCGCGCCAGC AGCTGCAGCA GGTGCCCGGG 
CTGCTGCACC GCATGGCCAA CCTGATGGGC ATTGAGTTCC ACGGTGAGCT GCCCAGTACA 
GAGGCTGTGG CCCTGGTGCT GGAGGAGATG TGGAAGTTCA ACCAGACCTA CCAGCTGGCC 
CATGGGACAG CTGAGGAGAA GATGCCGGTG TGGTATATCA TGGACGAGTT CGGTTCGCGG 
ATCCAGCACG CGGACGTGCC CAGCTTCGCC ACGGCACCCT TCTTCTACAT GCCGCAGCAG 
GTGGCCTACA CGCTGCTGTG GCCCCTGAGG GACCTGGACA CTGGCGAGGA GGTGACCCGA 
GACTTTGCCT ACGGAGAGAC GGACCCCCTG ATCCGGAAGT GCATGCTGCT GCCCTGGGCC 
CCCACCGACA TGCTGGACCT CAGCTCTTGC ACACCCGAGC CGCCCGCCGA GCACTACCAG 
GCCATTCTGG AGGAAAACAA GGAGAAGCTG CCACTTGACA TCAACCCCGT GGTGCACCCC 
CACGGCCACA TCTTCAAGGT CTACACGGAC GTGCAGCAGG TGGCCAGCAG CCTCACCCAC 
CCGCGCTTCA CCCTCACCCA GAGTGAGGCG GACGCCGACA TCCTCTTCAA CTTCTCACAC 
TTCAAGGACT ACAGGAAACT CAGCCAGGAG AGGCCAGGCG TGCTGCTGAA CCAGTTCCCC 
TGCGAGAACC TGCTGACTGT CAAGGACTGC CTGGCCTCCA TCGCGCGCCG GGCAGGTGGC 
CCCGAGGGCC CACCCTGGCT GCCCCGAACC TTCAACCTGC GCACTGAGCT GCCCCAGTTT 
GTCAGCTACT TCCAGCAGCG GGAAAGGTGG GGCGAGGACA ACCACTGGAT CTGCAAGCCC 
TGGAACCTGG CGCGCAGCCT GGACACCCAC GTCACCAAGA GCCTGCACAG CATCATCCGG 
CACCGAGAGA GCACCCCCAA GGTTGTGTCC AAGTACATCG AAAGTCCCGT GTTGTTCCTT 
CGAGAAGACG TGGGAAAGGT CAAGTTCGAC ATCCGCTACA TCGTGCTGCT GCGGTCAGTG 
AGGCCCCTAC GGTTGTTCGT GTATGATGTG TTCTGGCTGC GGTTCTCCAA CCGGGCCTTT 
GCACTCAACG ACCTGGATGA CTACGAGAAG CACTTCACGG TCATGAACTA TGACCCGGAT 
GTGGTGCTGA AGCAGGTGCA CTGTGAAGAG TTCATCCCCG AGTTTGAGAA GCAATACCCA 
GAATTTCCCT GGACGGACGT CCAGGCTGAG ATCTTCCGGG CCTTCACGGA GCTGTTCCAG 
GTGGCCTGTG CCAAGCCACC ACCCCTGGGC CTCTGCGACT ACCCCTCATC CCGGGCCATG 
TATGCCGTCG ACCTCATGCT GAAGTGGGAC AACGGCCCAG ATGGAAGGCG GGTGATGCAG 
CCGCAGATCC TGGAGGTGAA CTTCAACCCC GACTGTGAGC GAGCCTGCAG GTACCACCCC 
ACCTTCTTCA ACGACGTCTT CAGCACCTTG TTTCTGGACC AGCCCGGTGG CTGCCACGTT 
ACCTGCCTTG TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055955.1
CDS	66..2000
Translation	MEAERGPERRPAERSSPGQTPEEGAQALAEFAALHGPALRASGVPERYWGRLLHKLEHEVFDAGEVFGIMQVEEVEEEEDEAAREVRKQQPNPGNELCYKVIVTRESGLQAAHPNSIFLIDHAWTCRVEHARQQLQQVPGLLHRMANLMGIEFHGELPSTEAVALVLEEMWKFNQTYQLAHGTAEEKMPVWYIMDEFGSRIQHADVPSFATAPFFYMPQQVAYTLLWPLRDLDTGEEVTRDFAYGETDPLIRKCMLLPWAPTDMLDLSSCTPEPPAEHYQAILEENKEKLPLDINPVVHPHGHIFKVYTDVQQVASSLTHPRFTLTQSEADADILFNFSHFKDYRKLSQERPGVLLNQFPCENLLTVKDCLASIARRAGGPEGPPWLPRTFNLRTELPQFVSYFQQRERWGEDNHWICKPWNLARSLDTHVTKSLHSIIRHRESTPKVVSKYIESPVLFLREDVGKVKFDIRYIVLLRSVRPLRLFVYDVFWLRFSNRAFALNDLDDYEKHFTVMNYDPDVVLKQVHCEEFIPEFEKQYPEFPWTDVQAEIFRAFTELFQVACAKPPPLGLCDYPSSRAMYAVDLMLKWDNGPDGRRVMQPQILEVNFNPDCERACRYHPTFFNDVFSTLFLDQPGGCHVTCLV

Target ORF information:

RefSeq Version	NM_015140.4
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin tyrosine ligase like 12 (TTLL12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015140.4

ORF Insert Sequence:

ATGGAGGCCG AGCGGGGTCC CGAGCGCCGG CCTGCGGAGC GTAGCAGCCC GGGCCAGACG 
CCGGAGGAGG GCGCGCAGGC CTTGGCCGAG TTCGCGGCGC TGCACGGCCC GGCGCTGCGC 
GCTTCGGGGG TCCCCGAACG TTACTGGGGC CGCCTCCTGC ACAAGCTGGA GCACGAGGTT 
TTCGACGCTG GGGAAGTGTT TGGGATCATG CAAGTGGAGG AGGTAGAAGA GGAGGAGGAC 
GAGGCAGCCC GGGAGGTGCG GAAGCAGCAG CCCAACCCGG GGAACGAGCT GTGCTACAAG 
GTCATCGTGA CCAGGGAGAG CGGGCTCCAG GCAGCCCACC CCAACAGCAT CTTCCTCATC 
GACCACGCCT GGACGTGCCG TGTGGAGCAC GCGCGCCAGC AGCTGCAGCA GGTGCCCGGG 
CTGCTGCACC GCATGGCCAA CCTGATGGGC ATTGAGTTCC ACGGTGAGCT GCCCAGTACA 
GAGGCTGTGG CCCTGGTGCT GGAGGAGATG TGGAAGTTCA ACCAGACCTA CCAGCTGGCC 
CATGGGACAG CTGAGGAGAA GATGCCGGTG TGGTATATCA TGGACGAGTT CGGTTCGCGG 
ATCCAGCACG CGGACGTGCC CAGCTTCGCC ACGGCACCCT TCTTCTACAT GCCGCAGCAG 
GTGGCCTACA CGCTGCTGTG GCCCCTGAGG GACCTGGACA CTGGCGAGGA GGTGACCCGA 
GACTTTGCCT ACGGAGAGAC GGACCCCCTG ATCCGGAAGT GCATGCTGCT GCCCTGGGCC 
CCCACCGACA TGCTGGACCT CAGCTCTTGC ACACCCGAGC CGCCCGCCGA GCACTACCAG 
GCCATTCTGG AGGAAAACAA GGAGAAGCTG CCACTTGACA TCAACCCCGT GGTGCACCCC 
CACGGCCACA TCTTCAAGGT CTACACGGAC GTGCAGCAGG TGGCCAGCAG CCTCACCCAC 
CCGCGCTTCA CCCTCACCCA GAGTGAGGCG GACGCCGACA TCCTCTTCAA CTTCTCACAC 
TTCAAGGACT ACAGGAAACT CAGCCAGGAG AGGCCAGGCG TGCTGCTGAA CCAGTTCCCC 
TGCGAGAACC TGCTGACTGT CAAGGACTGC CTGGCCTCCA TCGCGCGCCG GGCAGGTGGC 
CCCGAGGGCC CACCCTGGCT GCCCCGAACC TTCAACCTGC GCACTGAGCT GCCCCAGTTT 
GTCAGCTACT TCCAGCAGCG GGAAAGGTGG GGCGAGGACA ACCACTGGAT CTGCAAGCCC 
TGGAACCTGG CGCGCAGCCT GGACACCCAC GTCACCAAGA GCCTGCACAG CATCATCCGG 
CACCGAGAGA GCACCCCCAA GGTTGTGTCC AAGTACATCG AAAGTCCCGT GTTGTTCCTT 
CGAGAAGACG TGGGAAAGGT CAAGTTCGAC ATCCGCTACA TCGTGCTGCT GCGGTCAGTG 
AGGCCCCTAC GGTTGTTCGT GTATGATGTG TTCTGGCTGC GGTTCTCCAA CCGGGCCTTT 
GCACTCAACG ACCTGGATGA CTACGAGAAG CACTTCACGG TCATGAACTA TGACCCGGAT 
GTGGTGCTGA AGCAGGTGCA CTGTGAAGAG TTCATCCCCG AGTTTGAGAA GCAATACCCA 
GAATTTCCCT GGACGGACGT CCAGGCTGAG ATCTTCCGGG CCTTCACGGA GCTGTTCCAG 
GTGGCCTGTG CCAAGCCACC ACCCCTGGGC CTCTGCGACT ACCCCTCATC CCGGGCCATG 
TATGCCGTCG ACCTCATGCT GAAGTGGGAC AACGGCCCAG ATGGAAGGCG GGTGATGCAG 
CCGCAGATCC TGGAGGTGAA CTTCAACCCC GACTGTGAGC GAGCCTGCAG GTACCACCCC 
ACCTTCTTCA ACGACGTCTT CAGCACCTTG TTTCTGGACC AGCCCGGTGG CTGCCACGTT 
ACCTGCCTTG TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS.
Journal of immunology (Baltimore, Md. : 1950)198(3)1274-1284(2017 Feb)
Ju LG,Zhu Y,Lei PJ,Yan D,Zhu K,Wang X,Li QL,Li XJ,Chen JW,Li LY,Wu M

Identification of a novel transcript isoform of the TTLL12 gene in human cancers.
Oncology reports36(6)3172-3180(2016 Dec)
Wen R,Xiao Y,Zhang Y,Yang M,Lin Y,Tang J

Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH).
Clinical oral investigations18(2)677-82(2014)
K?hnisch J,Thiering E,Heitm?ller D,Tiesler CM,Grallert H,Heinrich-Weltzien R,Hickel R,Heinrich J,,

Tubulin tyrosine ligase like 12, a TTLL family member with SET- and TTL-like domains and roles in histone and tubulin modifications and mitosis.
PloS one7(12)e51258(2012)
Brants J,Semenchenko K,Wasylyk C,Robert A,Carles A,Zambrano A,Pradeau-Aubreton K,Birck C,Schalken JA,Poch O,de Mey J,Wasylyk B

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TTLL12 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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