TTLL5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TTLL5
Entrez Gene ID	23093
Full Name	tubulin tyrosine ligase like 5
Synonyms	CORD19,KIAA0998,STAMP
General protein information	Preferred Names tubulin tyrosine ligase like 5 Names tubulin polyglutamylase TTLL5 SRC1 and TIF2 associated binding protein SRC1 and TIF2-associated modulatory protein tubulin tyrosine ligase-like family, member 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q24.3
Summary	This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.[provided by RefSeq, Feb 2010].
Disorder MIM:	612268
Disorder Html:	Cone-rod dystrophy 19, 615860 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_015072.4	NP_055887.3	tubulin polyglutamylase TTLL5
NM_015072.5	NP_055887.3	tubulin polyglutamylase TTLL5

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TTLL5	XP_005623734.1
Rattus norvegicus (Norway rat)	Ttll5	XP_006240435.1
Pan troglodytes (chimpanzee)	TTLL5	XP_001161309.3
	LOC703116	XP_002805202.1
Mus musculus (house mouse)	Ttll5	NP_001074892.2
Bos taurus (cattle)	TTLL5	XP_005212294.1
Gallus gallus (chicken)	TTLL5	NP_001026375.1
Homo sapiens (human)	TTLL5	NP_055887.3
Danio rerio (zebrafish)	LOC100538301	XP_003200448.2
Xenopus tropicalis (tropical clawed frog)	ttll5	NP_001121451.1

Gene Ontology
Bibliography

Related articles in PubMed

Novel splice-site mutation in TTLL5 causes cone dystrophy in a consanguineous family.
Dias MS, Hamel CP, Meunier I, Varin J, Blanchard S, Boyard F, Sahel JA, Zeitz C
Molecular vision23131-139(2017)

Mutations in the polyglutamylase gene TTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility.
Bedoni N, Haer-Wigman L, Vaclavik V, Tran VH, Farinelli P, Balzano S, Royer-Bertrand B, El-Asrag ME, Bonny O, Ikonomidis C, Litzistorf Y, Nikopoulos K, Yioti GG, Stefaniotou MI, McKibbin M, Booth AP, Ellingford JM, Black GC, Toomes C, Inglehearn CF, Hoyng CB, Bax N, Klaver CC, Thiadens AA, Murisier F, Schorderet DF, Ali M, Cremers FP, Andr?asson S, Munier FL, Rivolta C
Human molecular genetics25(20)4546-4555(2016 10)

Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused by TTLL5 mutations.
Sun X, Park JH, Gumerson J, Wu Z, Swaroop A, Qian H, Roll-Mecak A, Li T
Proceedings of the National Academy of Sciences of the United States of America113(21)E2925-34(2016 May)

Biallelic variants in TTLL5, encoding a tubulin glutamylase, cause retinal dystrophy.
Sergouniotis PI, Chakarova C, Murphy C, Becker M, Lenassi E, Arno G, Lek M, MacArthur DG, , Bhattacharya SS, Moore AT, Holder GE, Robson AG, Wolfrum U, Webster AR, Plagnol V
American journal of human genetics94(5)760-9(2014 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study has performed exome sequencing in 28 individuals with a similar disease phenotype and subsequently used a casecontrol approach to identify mutations in TTLL5 as a cause of recessive retinal dystrophy.
Title: Biallelic variants in TTLL5, encoding a tubulin glutamylase, cause retinal dystrophy.

This study indicates that a physiological function of STAMP in several settings is to modify cell growth rates in a manner that can be independent of steroid hormones.
Title: STAMP alters the growth of transformed and ovarian cancer cells.

STAMP is an important new, downstream component of GR action in both gene activation and gene repression.
Title: STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression.

The following TTLL5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TTLL5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17953	NM_015072.5 Latest version!	Homo sapiens tubulin tyrosine ligase like 5 (TTLL5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
View Old Accession Versions >>
OHu17953	NM_015072.4	Homo sapiens tubulin tyrosine ligase like 5 (TTLL5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TTLL5 ( NM_015072.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055887.3 Homo sapiens tubulin tyrosine ligase like 5 (TTLL5), mRNA.

Price & Availability↑

CloneID	OHu17953
Clone ID Related Accession (Same CDS sequence)	NM_015072.4 , NM_015072.5
Accession Version	NM_015072.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3846bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	tubulin polyglutamylase TTLL5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA195275.1, BC136472.1, AY237126.1 and GD137472.1. This sequence is a reference standard in the RefSeqGene project. On Mar 5, 2010 this sequence version replaced NM_015072.3. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.61814.1, AY237126.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCAATCG TGATGGCCCG GGACCTGGAG GAAACAGCAT CATCCTCAGA GGATGAGGAG 
GTCATAAGTC AAGAGGATCA TCCATGCATC ATGTGGACTG GAGGCTGCAG GAGAATTCCA 
GTTTTGGTAT TCCATGCCGA CGCTATTCTT ACAAAGGACA ACAATATTAG AGTAATTGGA 
GAACGTTATC ATTTGTCTTA TAAGATTGTA CGAACGGACA GTCGCCTAGT ACGCAGCATT 
CTGACAGCCC ATGGATTTCA TGAAGTTCAC CCAAGCAGCA CTGACTATAA CCTAATGTGG 
ACAGGATCCC ACCTGAAGCC CTTCTTACTG CGCACCCTCT CTGAAGCACA AAAAGTTAAT 
CACTTTCCCA GGTCTTATGA ACTTACCCGG AAGGACCGAC TGTACAAAAA CATTATTCGA 
ATGCAGCATA CACATGGATT CAAGGCTTTT CACATCCTCC CCCAGACCTT CCTCCTGCCA 
GCTGAGTACG CGGAATTTTG TAATTCATAT TCGAAGGACC GGGGACCTTG GATAGTAAAA 
CCAGTGGCAT CTTCAAGGGG GCGGGGCGTC TACCTGATCA ACAATCCAAA CCAGATCTCC 
CTGGAAGAGA ACATTTTGGT CTCCCGTTAC ATTAACAACC CCCTGCTCAT AGATGATTTC 
AAGTTTGACG TGCGCCTCTA TGTGCTCGTG ACTTCCTATG ATCCTCTTGT CATCTATCTC 
TATGAAGAAG GATTGGCTAG GTTTGCAACT GTGCGATATG ATCAAGGAGC CAAGAACATT 
CGGAACCAGT TCATGCATCT GACAAACTAC AGTGTCAACA AGAAAAGTGG AGATTACGTC 
AGTTGTGACG ATCCAGAAGT GGAGGATTAT GGAAACAAAT GGAGCATGAG TGCTATGCTT 
AGGTACCTGA AACAAGAAGG CAGAGATACA ACCGCATTGA TGGCCCATGT AGAAGACCTG 
ATCATTAAGA CTATAATCTC TGCTGAACTA GCTATTGCTA CTGCCTGTAA AACCTTTGTT 
CCTCATCGCA GCAGTTGTTT TGAACTCTAT GGCTTTGACG TGCTCATAGA TTCTACTCTG 
AAGCCATGGT TGTTGGAAGT GAATCTCTCT CCTTCTTTGG CCTGTGATGC GCCTCTGGAC 
CTAAAGATTA AAGCCAGTAT GATTTCAGAT ATGTTCACTG TTGTAGGATT TGTGTGCCAA 
GATCCTGCCC AGCGGGCATC AACTCGGCCA ATTTATCCCA CCTTTGAGTC TTCCAGGCGA 
AACCCTTTCC AGAAACCTCA GCGTTGCCGT CCACTCTCTG CCAGTGATGC GGAAATGAAA 
AACCTCGTGG GCTCAGCCCG GGAGAAAGGG CCAGGGAAGT TGGGTGGTTC TGTGCTTGGT 
CTGTCAATGG AGGAGATCAA AGTTTTACGA AGGGTGAAGG AGGAGAATGA TCGGCGAGGT 
GGATTTATTC GCATATTTCC TACATCTGAG ACATGGGAAA TATATGGGTC CTACCTCGAG 
CATAAGACCT CAATGAACTA TATGCTGGCA ACACGCCTCT TCCAGGACAG AATGACTGCT 
GATGGAGCGC CAGAATTGAA GATAGAGAGT CTGAATTCAA AGGCCAAGCT GCATGCTGCA 
CTTTACGAGA GGAAGCTCCT GTCTCTGGAG GTGCGAAAAC GTAGACGACG GAGTAGCAGA 
TTGAGGGCAA TGAGGCCAAA ATACCCAGTG ATTACCCAAC CAGCTGAAAT GAATGTTAAA 
ACTGAGACAG AGAGTGAAGA GGAGGAAGAA GTCGCATTAG ATAATGAAGA TGAAGAACAG 
GAGGCTTCCC AGGAGGAGTC TGCAGGATTT CTTAGAGAAA ATCAAGCCAA ATATACACCC 
TCATTGACAG CTTTGGTAGA AAATACACCC AAAGAAAATT CCATGAAAGT TCGTGAATGG 
AATAATAAAG GTGGACACTG CTGCAAACTT GAGACTCAGG AGCTAGAGCC TAAATTTAAC 
CTGATGCAGA TTCTTCAAGA TAATGGCAAT CTTAGCAAAA TGCAGGCCCG AATAGCATTC 
TCTGCCTATC TCCAGCATGT TCAAATTCGC CTGATGAAAG ACAGTGGCGG TCAGACGTTC 
AGTGCCAGTT GGGCTGCCAA AGAGGATGAA CAGATGGAGC TGGTTGTTCG TTTCCTCAAG 
CGAGCATCAA ATAACCTCCA GCATTCACTG AGGATGGTAT TACCCAGTCG ACGATTGGCA 
CTTCTGGAAC GCAGAAGAAT CCTGGCCCAC CAGCTGGGTG ACTTTATCAT TGTATACAAC 
AAGGAAACAG AACAAATGGC TGAAAAGAAA TCAAAGAAGA AAGTTGAGGA AGAAGAGGAA 
GATGGGGTGA ATATGGAAAA CTTTCAGGAG TTCATCAGAC AAGCAAGTGA GGCTGAACTG 
GAGGAGGTGT TGACTTTTTA TACCCAAAAG AACAAGTCTG CTAGTGTCTT CCTGGGGACT 
CACTCTAAAA TTTCTAAGAA CAACAACAAT TATTCTGATA GTGGGGCAAA AGGTGATCAC 
CCTGAGACTA TAATGGAAGA AGTGAAAATA AAGCCACCTA AACAGCAACA GACGACAGAA 
ATTCATTCTG ATAAATTATC TCGATTTACC ACTTCAGCAG AAAAAGAGGC AAAATTAGTT 
TATAGCAATT CCTCCTCTGG TCCTACTGCT ACTCTGCAGA AAATTCCCAA CACCCATTTG 
TCATCTGTTA CAACCTCTGA CCTCTCTCCA GGGCCTTGCC ACCATTCTTC TTTATCTCAA 
ATTCCTTCAG CTATCCCCAG CATGCCTCAC CAGCCAACAA TTTTACTGAA CACAGTCTCT 
GCCAGTGCTT CTCCCTGCCT ACATCCCGGG GCACAGAACA TCCCAAGCCC TACTGGCCTG 
CCACGCTGTC GATCAGGAAG TCACACCATT GGTCCCTTTT CTTCCTTCCA AAGTGCTGCA 
CACATCTATA GCCAGAAACT GTCTCGTCCC TCTTCAGCAA AGGCAGGATC GTGCTATCTA 
AACAAGCATC ATTCAGGAAT AGCCAAAACA CAAAAAGAGG GAGAAGATGC TTCTTTATAT 
AGCAAACGGT ACAACCAAAG TATGGTTACA GCTGAACTTC AGCGGCTAGC TGAGAAGCAG 
GCAGCGAGAC AGTATTCTCC ATCCAGCCAC ATCAACCTCC TCACCCAACA GGTAACAAAC 
CTGAATTTGG CAACTGGCAT CATAAACAGA AGCAGTGCTT CAGCTCCCCC AACCCTCCGA 
CCCATCATCA GTCCTAGTGG CCCGACATGG TCTACACAGT CAGACCCCCA AGCTCCCGAG 
AATCACTCCA GCTCTCCTGG AAGCAGGAGC CTGCAGACAG GGGGATTTGC CTGGGAAGGA 
GAAGTAGAAA ACAACGTGTA CAGCCAGGCT ACAGGGGTGG TCCCCCAGCA CAAGTATCAC 
CCCACAGCAG GCAGCTATCA GCTTCAATTT GCCCTGCAGC AACTTGAACA ACAAAAACTT 
CAGTCCCGGC AGCTCCTGGA CCAGAGTCGA GCCCGGCACC AGGCAATCTT TGGCAGCCAG 
ACACTACCTA ACTCCAATTT ATGGACAATG AATAATGGTG CAGGTTGTAG AATTTCCAGT 
GCCACAGCTA GTGGCCAGAA GCCAACCACT CTGCCACAAA AAGTGGTACC ACCTCCAAGT 
TCTTGCGCCT CCCTGGTTCC CAAACCCCCA CCCAACCACG AACAAGTGCT CAGAAGGGCA 
ACATCCCAGA AAGCTTCCAA AGGGTCCTCC GCGGAAGGGC AGCTGAATGG ACTCCAGAGC 
AGCCTTAACC CTGCAGCCTT TGTGCCCATC ACCAGCTCTA CAGATCCTGC TCACACTAAA 
ATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055887.3
CDS	276..4121
Translation	MPIVMARDLEETASSSEDEEVISQEDHPCIMWTGGCRRIPVLVFHADAILTKDNNIRVIGERYHLSYKIVRTDSRLVRSILTAHGFHEVHPSSTDYNLMWTGSHLKPFLLRTLSEAQKVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCNSYSKDRGPWIVKPVASSRGRGVYLINNPNQISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGAKNIRNQFMHLTNYSVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGRDTTALMAHVEDLIIKTIISAELAIATACKTFVPHRSSCFELYGFDVLIDSTLKPWLLEVNLSPSLACDAPLDLKIKASMISDMFTVVGFVCQDPAQRASTRPIYPTFESSRRNPFQKPQRCRPLSASDAEMKNLVGSAREKGPGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRMTADGAPELKIESLNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKYTPSLTALVENTPKENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNLSKMQARIAFSAYLQHVQIRLMKDSGGQTFSASWAAKEDEQMELVVRFLKRASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNKETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQASEAELEEVLTFYTQKNKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIKPPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSSGPTATLQKIPNTHLSSVTTSDLSPGPCHHSSLSQIPSAIPSMPHQPTILLNTVSASASPCLHPGAQNIPSPTGLPRCRSGSHTIGPFSSFQSAAHIYSQKLSRPSSAKAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVTAELQRLAEKQAARQYSPSSHINLLTQQVTNLNLATGIINRSSASAPPTLRPIISPSGPTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKVVPPPSSCASLVPKPPPNHEQVLRRATSQKASKGSSAEGQLNGLQSSLNPAAFVPITSSTDPAHTKI

Target ORF information:

RefSeq Version	NM_015072.4
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin tyrosine ligase like 5 (TTLL5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015072.4

ORF Insert Sequence:

ATGCCAATCG TGATGGCCCG GGACCTGGAG GAAACAGCAT CATCCTCAGA GGATGAGGAG 
GTCATAAGTC AAGAGGATCA TCCATGCATC ATGTGGACTG GAGGCTGCAG GAGAATTCCA 
GTTTTGGTAT TCCATGCCGA CGCTATTCTT ACAAAGGACA ACAATATTAG AGTAATTGGA 
GAACGTTATC ATTTGTCTTA TAAGATTGTA CGAACGGACA GTCGCCTAGT ACGCAGCATT 
CTGACAGCCC ATGGATTTCA TGAAGTTCAC CCAAGCAGCA CTGACTATAA CCTAATGTGG 
ACAGGATCCC ACCTGAAGCC CTTCTTACTG CGCACCCTCT CTGAAGCACA AAAAGTTAAT 
CACTTTCCCA GGTCTTATGA ACTTACCCGG AAGGACCGAC TGTACAAAAA CATTATTCGA 
ATGCAGCATA CACATGGATT CAAGGCTTTT CACATCCTCC CCCAGACCTT CCTCCTGCCA 
GCTGAGTACG CGGAATTTTG TAATTCATAT TCGAAGGACC GGGGACCTTG GATAGTAAAA 
CCAGTGGCAT CTTCAAGGGG GCGGGGCGTC TACCTGATCA ACAATCCAAA CCAGATCTCC 
CTGGAAGAGA ACATTTTGGT CTCCCGTTAC ATTAACAACC CCCTGCTCAT AGATGATTTC 
AAGTTTGACG TGCGCCTCTA TGTGCTCGTG ACTTCCTATG ATCCTCTTGT CATCTATCTC 
TATGAAGAAG GATTGGCTAG GTTTGCAACT GTGCGATATG ATCAAGGAGC CAAGAACATT 
CGGAACCAGT TCATGCATCT GACAAACTAC AGTGTCAACA AGAAAAGTGG AGATTACGTC 
AGTTGTGACG ATCCAGAAGT GGAGGATTAT GGAAACAAAT GGAGCATGAG TGCTATGCTT 
AGGTACCTGA AACAAGAAGG CAGAGATACA ACCGCATTGA TGGCCCATGT AGAAGACCTG 
ATCATTAAGA CTATAATCTC TGCTGAACTA GCTATTGCTA CTGCCTGTAA AACCTTTGTT 
CCTCATCGCA GCAGTTGTTT TGAACTCTAT GGCTTTGACG TGCTCATAGA TTCTACTCTG 
AAGCCATGGT TGTTGGAAGT GAATCTCTCT CCTTCTTTGG CCTGTGATGC GCCTCTGGAC 
CTAAAGATTA AAGCCAGTAT GATTTCAGAT ATGTTCACTG TTGTAGGATT TGTGTGCCAA 
GATCCTGCCC AGCGGGCATC AACTCGGCCA ATTTATCCCA CCTTTGAGTC TTCCAGGCGA 
AACCCTTTCC AGAAACCTCA GCGTTGCCGT CCACTCTCTG CCAGTGATGC GGAAATGAAA 
AACCTCGTGG GCTCAGCCCG GGAGAAAGGG CCAGGGAAGT TGGGTGGTTC TGTGCTTGGT 
CTGTCAATGG AGGAGATCAA AGTTTTACGA AGGGTGAAGG AGGAGAATGA TCGGCGAGGT 
GGATTTATTC GCATATTTCC TACATCTGAG ACATGGGAAA TATATGGGTC CTACCTCGAG 
CATAAGACCT CAATGAACTA TATGCTGGCA ACACGCCTCT TCCAGGACAG AATGACTGCT 
GATGGAGCGC CAGAATTGAA GATAGAGAGT CTGAATTCAA AGGCCAAGCT GCATGCTGCA 
CTTTACGAGA GGAAGCTCCT GTCTCTGGAG GTGCGAAAAC GTAGACGACG GAGTAGCAGA 
TTGAGGGCAA TGAGGCCAAA ATACCCAGTG ATTACCCAAC CAGCTGAAAT GAATGTTAAA 
ACTGAGACAG AGAGTGAAGA GGAGGAAGAA GTCGCATTAG ATAATGAAGA TGAAGAACAG 
GAGGCTTCCC AGGAGGAGTC TGCAGGATTT CTTAGAGAAA ATCAAGCCAA ATATACACCC 
TCATTGACAG CTTTGGTAGA AAATACACCC AAAGAAAATT CCATGAAAGT TCGTGAATGG 
AATAATAAAG GTGGACACTG CTGCAAACTT GAGACTCAGG AGCTAGAGCC TAAATTTAAC 
CTGATGCAGA TTCTTCAAGA TAATGGCAAT CTTAGCAAAA TGCAGGCCCG AATAGCATTC 
TCTGCCTATC TCCAGCATGT TCAAATTCGC CTGATGAAAG ACAGTGGCGG TCAGACGTTC 
AGTGCCAGTT GGGCTGCCAA AGAGGATGAA CAGATGGAGC TGGTTGTTCG TTTCCTCAAG 
CGAGCATCAA ATAACCTCCA GCATTCACTG AGGATGGTAT TACCCAGTCG ACGATTGGCA 
CTTCTGGAAC GCAGAAGAAT CCTGGCCCAC CAGCTGGGTG ACTTTATCAT TGTATACAAC 
AAGGAAACAG AACAAATGGC TGAAAAGAAA TCAAAGAAGA AAGTTGAGGA AGAAGAGGAA 
GATGGGGTGA ATATGGAAAA CTTTCAGGAG TTCATCAGAC AAGCAAGTGA GGCTGAACTG 
GAGGAGGTGT TGACTTTTTA TACCCAAAAG AACAAGTCTG CTAGTGTCTT CCTGGGGACT 
CACTCTAAAA TTTCTAAGAA CAACAACAAT TATTCTGATA GTGGGGCAAA AGGTGATCAC 
CCTGAGACTA TAATGGAAGA AGTGAAAATA AAGCCACCTA AACAGCAACA GACGACAGAA 
ATTCATTCTG ATAAATTATC TCGATTTACC ACTTCAGCAG AAAAAGAGGC AAAATTAGTT 
TATAGCAATT CCTCCTCTGG TCCTACTGCT ACTCTGCAGA AAATTCCCAA CACCCATTTG 
TCATCTGTTA CAACCTCTGA CCTCTCTCCA GGGCCTTGCC ACCATTCTTC TTTATCTCAA 
ATTCCTTCAG CTATCCCCAG CATGCCTCAC CAGCCAACAA TTTTACTGAA CACAGTCTCT 
GCCAGTGCTT CTCCCTGCCT ACATCCCGGG GCACAGAACA TCCCAAGCCC TACTGGCCTG 
CCACGCTGTC GATCAGGAAG TCACACCATT GGTCCCTTTT CTTCCTTCCA AAGTGCTGCA 
CACATCTATA GCCAGAAACT GTCTCGTCCC TCTTCAGCAA AGGCAGGATC GTGCTATCTA 
AACAAGCATC ATTCAGGAAT AGCCAAAACA CAAAAAGAGG GAGAAGATGC TTCTTTATAT 
AGCAAACGGT ACAACCAAAG TATGGTTACA GCTGAACTTC AGCGGCTAGC TGAGAAGCAG 
GCAGCGAGAC AGTATTCTCC ATCCAGCCAC ATCAACCTCC TCACCCAACA GGTAACAAAC 
CTGAATTTGG CAACTGGCAT CATAAACAGA AGCAGTGCTT CAGCTCCCCC AACCCTCCGA 
CCCATCATCA GTCCTAGTGG CCCGACATGG TCTACACAGT CAGACCCCCA AGCTCCCGAG 
AATCACTCCA GCTCTCCTGG AAGCAGGAGC CTGCAGACAG GGGGATTTGC CTGGGAAGGA 
GAAGTAGAAA ACAACGTGTA CAGCCAGGCT ACAGGGGTGG TCCCCCAGCA CAAGTATCAC 
CCCACAGCAG GCAGCTATCA GCTTCAATTT GCCCTGCAGC AACTTGAACA ACAAAAACTT 
CAGTCCCGGC AGCTCCTGGA CCAGAGTCGA GCCCGGCACC AGGCAATCTT TGGCAGCCAG 
ACACTACCTA ACTCCAATTT ATGGACAATG AATAATGGTG CAGGTTGTAG AATTTCCAGT 
GCCACAGCTA GTGGCCAGAA GCCAACCACT CTGCCACAAA AAGTGGTACC ACCTCCAAGT 
TCTTGCGCCT CCCTGGTTCC CAAACCCCCA CCCAACCACG AACAAGTGCT CAGAAGGGCA 
ACATCCCAGA AAGCTTCCAA AGGGTCCTCC GCGGAAGGGC AGCTGAATGG ACTCCAGAGC 
AGCCTTAACC CTGCAGCCTT TGTGCCCATC ACCAGCTCTA CAGATCCTGC TCACACTAAA 
ATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TTLL5 ( NM_015072.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055887.3 Homo sapiens tubulin tyrosine ligase like 5 (TTLL5), mRNA.

Price & Availability↑

CloneID	OHu17953
Clone ID Related Accession (Same CDS sequence)	NM_015072.4 , NM_015072.5
Accession Version	NM_015072.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3846bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	tubulin polyglutamylase TTLL5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA195275.1, BC136472.1, AY237126.1 and GD137472.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_015072.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.61814.1, AY237126.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000298832.14/ ENSP00000298832.9 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCAATCG TGATGGCCCG GGACCTGGAG GAAACAGCAT CATCCTCAGA GGATGAGGAG 
GTCATAAGTC AAGAGGATCA TCCATGCATC ATGTGGACTG GAGGCTGCAG GAGAATTCCA 
GTTTTGGTAT TCCATGCCGA CGCTATTCTT ACAAAGGACA ACAATATTAG AGTAATTGGA 
GAACGTTATC ATTTGTCTTA TAAGATTGTA CGAACGGACA GTCGCCTAGT ACGCAGCATT 
CTGACAGCCC ATGGATTTCA TGAAGTTCAC CCAAGCAGCA CTGACTATAA CCTAATGTGG 
ACAGGATCCC ACCTGAAGCC CTTCTTACTG CGCACCCTCT CTGAAGCACA AAAAGTTAAT 
CACTTTCCCA GGTCTTATGA ACTTACCCGG AAGGACCGAC TGTACAAAAA CATTATTCGA 
ATGCAGCATA CACATGGATT CAAGGCTTTT CACATCCTCC CCCAGACCTT CCTCCTGCCA 
GCTGAGTACG CGGAATTTTG TAATTCATAT TCGAAGGACC GGGGACCTTG GATAGTAAAA 
CCAGTGGCAT CTTCAAGGGG GCGGGGCGTC TACCTGATCA ACAATCCAAA CCAGATCTCC 
CTGGAAGAGA ACATTTTGGT CTCCCGTTAC ATTAACAACC CCCTGCTCAT AGATGATTTC 
AAGTTTGACG TGCGCCTCTA TGTGCTCGTG ACTTCCTATG ATCCTCTTGT CATCTATCTC 
TATGAAGAAG GATTGGCTAG GTTTGCAACT GTGCGATATG ATCAAGGAGC CAAGAACATT 
CGGAACCAGT TCATGCATCT GACAAACTAC AGTGTCAACA AGAAAAGTGG AGATTACGTC 
AGTTGTGACG ATCCAGAAGT GGAGGATTAT GGAAACAAAT GGAGCATGAG TGCTATGCTT 
AGGTACCTGA AACAAGAAGG CAGAGATACA ACCGCATTGA TGGCCCATGT AGAAGACCTG 
ATCATTAAGA CTATAATCTC TGCTGAACTA GCTATTGCTA CTGCCTGTAA AACCTTTGTT 
CCTCATCGCA GCAGTTGTTT TGAACTCTAT GGCTTTGACG TGCTCATAGA TTCTACTCTG 
AAGCCATGGT TGTTGGAAGT GAATCTCTCT CCTTCTTTGG CCTGTGATGC GCCTCTGGAC 
CTAAAGATTA AAGCCAGTAT GATTTCAGAT ATGTTCACTG TTGTAGGATT TGTGTGCCAA 
GATCCTGCCC AGCGGGCATC AACTCGGCCA ATTTATCCCA CCTTTGAGTC TTCCAGGCGA 
AACCCTTTCC AGAAACCTCA GCGTTGCCGT CCACTCTCTG CCAGTGATGC GGAAATGAAA 
AACCTCGTGG GCTCAGCCCG GGAGAAAGGG CCAGGGAAGT TGGGTGGTTC TGTGCTTGGT 
CTGTCAATGG AGGAGATCAA AGTTTTACGA AGGGTGAAGG AGGAGAATGA TCGGCGAGGT 
GGATTTATTC GCATATTTCC TACATCTGAG ACATGGGAAA TATATGGGTC CTACCTCGAG 
CATAAGACCT CAATGAACTA TATGCTGGCA ACACGCCTCT TCCAGGACAG AATGACTGCT 
GATGGAGCGC CAGAATTGAA GATAGAGAGT CTGAATTCAA AGGCCAAGCT GCATGCTGCA 
CTTTACGAGA GGAAGCTCCT GTCTCTGGAG GTGCGAAAAC GTAGACGACG GAGTAGCAGA 
TTGAGGGCAA TGAGGCCAAA ATACCCAGTG ATTACCCAAC CAGCTGAAAT GAATGTTAAA 
ACTGAGACAG AGAGTGAAGA GGAGGAAGAA GTCGCATTAG ATAATGAAGA TGAAGAACAG 
GAGGCTTCCC AGGAGGAGTC TGCAGGATTT CTTAGAGAAA ATCAAGCCAA ATATACACCC 
TCATTGACAG CTTTGGTAGA AAATACACCC AAAGAAAATT CCATGAAAGT TCGTGAATGG 
AATAATAAAG GTGGACACTG CTGCAAACTT GAGACTCAGG AGCTAGAGCC TAAATTTAAC 
CTGATGCAGA TTCTTCAAGA TAATGGCAAT CTTAGCAAAA TGCAGGCCCG AATAGCATTC 
TCTGCCTATC TCCAGCATGT TCAAATTCGC CTGATGAAAG ACAGTGGCGG TCAGACGTTC 
AGTGCCAGTT GGGCTGCCAA AGAGGATGAA CAGATGGAGC TGGTTGTTCG TTTCCTCAAG 
CGAGCATCAA ATAACCTCCA GCATTCACTG AGGATGGTAT TACCCAGTCG ACGATTGGCA 
CTTCTGGAAC GCAGAAGAAT CCTGGCCCAC CAGCTGGGTG ACTTTATCAT TGTATACAAC 
AAGGAAACAG AACAAATGGC TGAAAAGAAA TCAAAGAAGA AAGTTGAGGA AGAAGAGGAA 
GATGGGGTGA ATATGGAAAA CTTTCAGGAG TTCATCAGAC AAGCAAGTGA GGCTGAACTG 
GAGGAGGTGT TGACTTTTTA TACCCAAAAG AACAAGTCTG CTAGTGTCTT CCTGGGGACT 
CACTCTAAAA TTTCTAAGAA CAACAACAAT TATTCTGATA GTGGGGCAAA AGGTGATCAC 
CCTGAGACTA TAATGGAAGA AGTGAAAATA AAGCCACCTA AACAGCAACA GACGACAGAA 
ATTCATTCTG ATAAATTATC TCGATTTACC ACTTCAGCAG AAAAAGAGGC AAAATTAGTT 
TATAGCAATT CCTCCTCTGG TCCTACTGCT ACTCTGCAGA AAATTCCCAA CACCCATTTG 
TCATCTGTTA CAACCTCTGA CCTCTCTCCA GGGCCTTGCC ACCATTCTTC TTTATCTCAA 
ATTCCTTCAG CTATCCCCAG CATGCCTCAC CAGCCAACAA TTTTACTGAA CACAGTCTCT 
GCCAGTGCTT CTCCCTGCCT ACATCCCGGG GCACAGAACA TCCCAAGCCC TACTGGCCTG 
CCACGCTGTC GATCAGGAAG TCACACCATT GGTCCCTTTT CTTCCTTCCA AAGTGCTGCA 
CACATCTATA GCCAGAAACT GTCTCGTCCC TCTTCAGCAA AGGCAGGATC GTGCTATCTA 
AACAAGCATC ATTCAGGAAT AGCCAAAACA CAAAAAGAGG GAGAAGATGC TTCTTTATAT 
AGCAAACGGT ACAACCAAAG TATGGTTACA GCTGAACTTC AGCGGCTAGC TGAGAAGCAG 
GCAGCGAGAC AGTATTCTCC ATCCAGCCAC ATCAACCTCC TCACCCAACA GGTAACAAAC 
CTGAATTTGG CAACTGGCAT CATAAACAGA AGCAGTGCTT CAGCTCCCCC AACCCTCCGA 
CCCATCATCA GTCCTAGTGG CCCGACATGG TCTACACAGT CAGACCCCCA AGCTCCCGAG 
AATCACTCCA GCTCTCCTGG AAGCAGGAGC CTGCAGACAG GGGGATTTGC CTGGGAAGGA 
GAAGTAGAAA ACAACGTGTA CAGCCAGGCT ACAGGGGTGG TCCCCCAGCA CAAGTATCAC 
CCCACAGCAG GCAGCTATCA GCTTCAATTT GCCCTGCAGC AACTTGAACA ACAAAAACTT 
CAGTCCCGGC AGCTCCTGGA CCAGAGTCGA GCCCGGCACC AGGCAATCTT TGGCAGCCAG 
ACACTACCTA ACTCCAATTT ATGGACAATG AATAATGGTG CAGGTTGTAG AATTTCCAGT 
GCCACAGCTA GTGGCCAGAA GCCAACCACT CTGCCACAAA AAGTGGTACC ACCTCCAAGT 
TCTTGCGCCT CCCTGGTTCC CAAACCCCCA CCCAACCACG AACAAGTGCT CAGAAGGGCA 
ACATCCCAGA AAGCTTCCAA AGGGTCCTCC GCGGAAGGGC AGCTGAATGG ACTCCAGAGC 
AGCCTTAACC CTGCAGCCTT TGTGCCCATC ACCAGCTCTA CAGATCCTGC TCACACTAAA 
ATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055887.3
CDS	238..4083
Translation	MPIVMARDLEETASSSEDEEVISQEDHPCIMWTGGCRRIPVLVFHADAILTKDNNIRVIGERYHLSYKIVRTDSRLVRSILTAHGFHEVHPSSTDYNLMWTGSHLKPFLLRTLSEAQKVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCNSYSKDRGPWIVKPVASSRGRGVYLINNPNQISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGAKNIRNQFMHLTNYSVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGRDTTALMAHVEDLIIKTIISAELAIATACKTFVPHRSSCFELYGFDVLIDSTLKPWLLEVNLSPSLACDAPLDLKIKASMISDMFTVVGFVCQDPAQRASTRPIYPTFESSRRNPFQKPQRCRPLSASDAEMKNLVGSAREKGPGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRMTADGAPELKIESLNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKYTPSLTALVENTPKENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNLSKMQARIAFSAYLQHVQIRLMKDSGGQTFSASWAAKEDEQMELVVRFLKRASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNKETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQASEAELEEVLTFYTQKNKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIKPPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSSGPTATLQKIPNTHLSSVTTSDLSPGPCHHSSLSQIPSAIPSMPHQPTILLNTVSASASPCLHPGAQNIPSPTGLPRCRSGSHTIGPFSSFQSAAHIYSQKLSRPSSAKAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVTAELQRLAEKQAARQYSPSSHINLLTQQVTNLNLATGIINRSSASAPPTLRPIISPSGPTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKVVPPPSSCASLVPKPPPNHEQVLRRATSQKASKGSSAEGQLNGLQSSLNPAAFVPITSSTDPAHTKI

Target ORF information:

RefSeq Version	NM_015072.5
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin tyrosine ligase like 5 (TTLL5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015072.5

ORF Insert Sequence:

ATGCCAATCG TGATGGCCCG GGACCTGGAG GAAACAGCAT CATCCTCAGA GGATGAGGAG 
GTCATAAGTC AAGAGGATCA TCCATGCATC ATGTGGACTG GAGGCTGCAG GAGAATTCCA 
GTTTTGGTAT TCCATGCCGA CGCTATTCTT ACAAAGGACA ACAATATTAG AGTAATTGGA 
GAACGTTATC ATTTGTCTTA TAAGATTGTA CGAACGGACA GTCGCCTAGT ACGCAGCATT 
CTGACAGCCC ATGGATTTCA TGAAGTTCAC CCAAGCAGCA CTGACTATAA CCTAATGTGG 
ACAGGATCCC ACCTGAAGCC CTTCTTACTG CGCACCCTCT CTGAAGCACA AAAAGTTAAT 
CACTTTCCCA GGTCTTATGA ACTTACCCGG AAGGACCGAC TGTACAAAAA CATTATTCGA 
ATGCAGCATA CACATGGATT CAAGGCTTTT CACATCCTCC CCCAGACCTT CCTCCTGCCA 
GCTGAGTACG CGGAATTTTG TAATTCATAT TCGAAGGACC GGGGACCTTG GATAGTAAAA 
CCAGTGGCAT CTTCAAGGGG GCGGGGCGTC TACCTGATCA ACAATCCAAA CCAGATCTCC 
CTGGAAGAGA ACATTTTGGT CTCCCGTTAC ATTAACAACC CCCTGCTCAT AGATGATTTC 
AAGTTTGACG TGCGCCTCTA TGTGCTCGTG ACTTCCTATG ATCCTCTTGT CATCTATCTC 
TATGAAGAAG GATTGGCTAG GTTTGCAACT GTGCGATATG ATCAAGGAGC CAAGAACATT 
CGGAACCAGT TCATGCATCT GACAAACTAC AGTGTCAACA AGAAAAGTGG AGATTACGTC 
AGTTGTGACG ATCCAGAAGT GGAGGATTAT GGAAACAAAT GGAGCATGAG TGCTATGCTT 
AGGTACCTGA AACAAGAAGG CAGAGATACA ACCGCATTGA TGGCCCATGT AGAAGACCTG 
ATCATTAAGA CTATAATCTC TGCTGAACTA GCTATTGCTA CTGCCTGTAA AACCTTTGTT 
CCTCATCGCA GCAGTTGTTT TGAACTCTAT GGCTTTGACG TGCTCATAGA TTCTACTCTG 
AAGCCATGGT TGTTGGAAGT GAATCTCTCT CCTTCTTTGG CCTGTGATGC GCCTCTGGAC 
CTAAAGATTA AAGCCAGTAT GATTTCAGAT ATGTTCACTG TTGTAGGATT TGTGTGCCAA 
GATCCTGCCC AGCGGGCATC AACTCGGCCA ATTTATCCCA CCTTTGAGTC TTCCAGGCGA 
AACCCTTTCC AGAAACCTCA GCGTTGCCGT CCACTCTCTG CCAGTGATGC GGAAATGAAA 
AACCTCGTGG GCTCAGCCCG GGAGAAAGGG CCAGGGAAGT TGGGTGGTTC TGTGCTTGGT 
CTGTCAATGG AGGAGATCAA AGTTTTACGA AGGGTGAAGG AGGAGAATGA TCGGCGAGGT 
GGATTTATTC GCATATTTCC TACATCTGAG ACATGGGAAA TATATGGGTC CTACCTCGAG 
CATAAGACCT CAATGAACTA TATGCTGGCA ACACGCCTCT TCCAGGACAG AATGACTGCT 
GATGGAGCGC CAGAATTGAA GATAGAGAGT CTGAATTCAA AGGCCAAGCT GCATGCTGCA 
CTTTACGAGA GGAAGCTCCT GTCTCTGGAG GTGCGAAAAC GTAGACGACG GAGTAGCAGA 
TTGAGGGCAA TGAGGCCAAA ATACCCAGTG ATTACCCAAC CAGCTGAAAT GAATGTTAAA 
ACTGAGACAG AGAGTGAAGA GGAGGAAGAA GTCGCATTAG ATAATGAAGA TGAAGAACAG 
GAGGCTTCCC AGGAGGAGTC TGCAGGATTT CTTAGAGAAA ATCAAGCCAA ATATACACCC 
TCATTGACAG CTTTGGTAGA AAATACACCC AAAGAAAATT CCATGAAAGT TCGTGAATGG 
AATAATAAAG GTGGACACTG CTGCAAACTT GAGACTCAGG AGCTAGAGCC TAAATTTAAC 
CTGATGCAGA TTCTTCAAGA TAATGGCAAT CTTAGCAAAA TGCAGGCCCG AATAGCATTC 
TCTGCCTATC TCCAGCATGT TCAAATTCGC CTGATGAAAG ACAGTGGCGG TCAGACGTTC 
AGTGCCAGTT GGGCTGCCAA AGAGGATGAA CAGATGGAGC TGGTTGTTCG TTTCCTCAAG 
CGAGCATCAA ATAACCTCCA GCATTCACTG AGGATGGTAT TACCCAGTCG ACGATTGGCA 
CTTCTGGAAC GCAGAAGAAT CCTGGCCCAC CAGCTGGGTG ACTTTATCAT TGTATACAAC 
AAGGAAACAG AACAAATGGC TGAAAAGAAA TCAAAGAAGA AAGTTGAGGA AGAAGAGGAA 
GATGGGGTGA ATATGGAAAA CTTTCAGGAG TTCATCAGAC AAGCAAGTGA GGCTGAACTG 
GAGGAGGTGT TGACTTTTTA TACCCAAAAG AACAAGTCTG CTAGTGTCTT CCTGGGGACT 
CACTCTAAAA TTTCTAAGAA CAACAACAAT TATTCTGATA GTGGGGCAAA AGGTGATCAC 
CCTGAGACTA TAATGGAAGA AGTGAAAATA AAGCCACCTA AACAGCAACA GACGACAGAA 
ATTCATTCTG ATAAATTATC TCGATTTACC ACTTCAGCAG AAAAAGAGGC AAAATTAGTT 
TATAGCAATT CCTCCTCTGG TCCTACTGCT ACTCTGCAGA AAATTCCCAA CACCCATTTG 
TCATCTGTTA CAACCTCTGA CCTCTCTCCA GGGCCTTGCC ACCATTCTTC TTTATCTCAA 
ATTCCTTCAG CTATCCCCAG CATGCCTCAC CAGCCAACAA TTTTACTGAA CACAGTCTCT 
GCCAGTGCTT CTCCCTGCCT ACATCCCGGG GCACAGAACA TCCCAAGCCC TACTGGCCTG 
CCACGCTGTC GATCAGGAAG TCACACCATT GGTCCCTTTT CTTCCTTCCA AAGTGCTGCA 
CACATCTATA GCCAGAAACT GTCTCGTCCC TCTTCAGCAA AGGCAGGATC GTGCTATCTA 
AACAAGCATC ATTCAGGAAT AGCCAAAACA CAAAAAGAGG GAGAAGATGC TTCTTTATAT 
AGCAAACGGT ACAACCAAAG TATGGTTACA GCTGAACTTC AGCGGCTAGC TGAGAAGCAG 
GCAGCGAGAC AGTATTCTCC ATCCAGCCAC ATCAACCTCC TCACCCAACA GGTAACAAAC 
CTGAATTTGG CAACTGGCAT CATAAACAGA AGCAGTGCTT CAGCTCCCCC AACCCTCCGA 
CCCATCATCA GTCCTAGTGG CCCGACATGG TCTACACAGT CAGACCCCCA AGCTCCCGAG 
AATCACTCCA GCTCTCCTGG AAGCAGGAGC CTGCAGACAG GGGGATTTGC CTGGGAAGGA 
GAAGTAGAAA ACAACGTGTA CAGCCAGGCT ACAGGGGTGG TCCCCCAGCA CAAGTATCAC 
CCCACAGCAG GCAGCTATCA GCTTCAATTT GCCCTGCAGC AACTTGAACA ACAAAAACTT 
CAGTCCCGGC AGCTCCTGGA CCAGAGTCGA GCCCGGCACC AGGCAATCTT TGGCAGCCAG 
ACACTACCTA ACTCCAATTT ATGGACAATG AATAATGGTG CAGGTTGTAG AATTTCCAGT 
GCCACAGCTA GTGGCCAGAA GCCAACCACT CTGCCACAAA AAGTGGTACC ACCTCCAAGT 
TCTTGCGCCT CCCTGGTTCC CAAACCCCCA CCCAACCACG AACAAGTGCT CAGAAGGGCA 
ACATCCCAGA AAGCTTCCAA AGGGTCCTCC GCGGAAGGGC AGCTGAATGG ACTCCAGAGC 
AGCCTTAACC CTGCAGCCTT TGTGCCCATC ACCAGCTCTA CAGATCCTGC TCACACTAAA 
ATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel splice-site mutation in TTLL5 causes cone dystrophy in a consanguineous family.
Molecular vision23131-139(2017)
Dias MS,Hamel CP,Meunier I,Varin J,Blanchard S,Boyard F,Sahel JA,Zeitz C

Mutations in the polyglutamylase gene TTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility.
Human molecular genetics25(20)4546-4555(2016 10)
Bedoni N,Haer-Wigman L,Vaclavik V,Tran VH,Farinelli P,Balzano S,Royer-Bertrand B,El-Asrag ME,Bonny O,Ikonomidis C,Litzistorf Y,Nikopoulos K,Yioti GG,Stefaniotou MI,McKibbin M,Booth AP,Ellingford JM,Black GC,Toomes C,Inglehearn CF,Hoyng CB,Bax N,Klaver CC,Thiadens AA,Murisier F,Schorderet DF,Ali M,Cremers FP,Andr?asson S,Munier FL,Rivolta C

Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused by TTLL5 mutations.
Proceedings of the National Academy of Sciences of the United States of America113(21)E2925-34(2016 May)
Sun X,Park JH,Gumerson J,Wu Z,Swaroop A,Qian H,Roll-Mecak A,Li T

Biallelic variants in TTLL5, encoding a tubulin glutamylase, cause retinal dystrophy.
American journal of human genetics94(5)760-9(2014 May)
Sergouniotis PI,Chakarova C,Murphy C,Becker M,Lenassi E,Arno G,Lek M,MacArthur DG,,Bhattacharya SS,Moore AT,Holder GE,Robson AG,Wolfrum U,Webster AR,Plagnol V

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TTLL5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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