FOXI1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FOXI1
Entrez Gene ID	2299
Full Name	forkhead box I1
Synonyms	FKH10,FKHL10,FREAC-6,FREAC6,HFH-3,HFH3
General protein information	Preferred Names forkhead box I1 Names forkhead box protein I1 HNF-3/fork-head homolog-3 forkhead-like 10 forkhead-related activator 6 forkhead-related protein FKHL10 forkhead-related transcription factor 6 hepatocyte nuclear factor 3 forkhead homolog 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q35.1
Summary	This gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene may play an important role in the development of the cochlea and vestibulum, as well as in embryogenesis. The encoded protein has been found to be required for the transcription of four subunits of a proton pump found in the inner ear, the kidney, and the epididymis. Mutations in this gene have been associated with deafness, autosomal recessive 4. [provided by RefSeq, Jan 2017].
Disorder MIM:	601093
Disorder Html:	Enlarged vestibular aqueduct, 600791 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_144769.2	NP_658982.1	forkhead box protein I1 isoform b
NM_012188.4	NP_036320.2	forkhead box protein I1 isoform a
NM_012188.5	NP_036320.2	forkhead box protein I1 isoform a
NM_144769.3	NP_658982.1	forkhead box protein I1 isoform b

Pathways from BioSystems

Homologies

	FOXI1	XP_001092246.1
Gallus gallus (chicken)	FOXI1	XP_425185.1
Rattus norvegicus (Norway rat)	Foxi1	NP_001099246.1
Pan troglodytes (chimpanzee)	FOXI1	XP_527110.1
Homo sapiens (human)	FOXI1	NP_036320.2
Canis lupus familiaris (dog)	FOXI1	XP_546245.2
Mus musculus (house mouse)	Foxi1	NP_076396.3
Bos taurus (cattle)	FOXI1	NP_001179172.1
Danio rerio (zebrafish)	foxi3b	NP_944600.1
Danio rerio (zebrafish)	foxi3a	NP_944599.2
Xenopus tropicalis (tropical clawed frog)	foxi1	NP_988949.1

Gene Ontology
Bibliography

Related articles in PubMed

Acidosis and Deafness in Patients with Recessive Mutations in FOXI1.
Enerb?ck S, Nilsson D, Edwards N, Heglind M, Alkanderi S, Ashton E, Deeb A, Kokash FEB, Bakhsh ARA, Van't Hoff W, Walsh SB, D'Arco F, Daryadel A, Bourgeois S, Wagner CA, Kleta R, Bockenhauer D, Sayer JA
Journal of the American Society of Nephrology : JASN(2017 Dec)

miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/?-catenin signaling in the development of gastric cancer.
Sun R, Liu Z, Tong D, Yang Y, Guo B, Wang X, Zhao L, Huang C
Cell death & disease8(3)e2714(2017 Mar)

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Navarini AA, Simpson MA, Weale M, Knight J, Carlavan I, Reiniche P, Burden DA, Layton A, Bataille V, Allen M, Pleass R, Pink A, Creamer D, English J, Munn S, Walton S, , Willis C, D?ret S, Voegel JJ, Spector T, Smith CH, Trembath RC, Barker JN
Nature communications54020(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study reveals that Foxi1/miR-491-5p/Wnt3a/beta-catenin signaling is critical in the progression of GC. Targeting the pathway described in this study may open up new prospects to restrict the progression of gastric cancer
Title: miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/?-catenin signaling in the development of gastric cancer.

We found no evidence for a significant association between mutations of KCNJ10 and FOXI1 with SLC26A4 in Pendred syndrome/enlarged vestibular aqueducts.
Title: Lack of significant association between mutations of KCNJ10 or FOXI1 and SLC26A4 mutations in Pendred syndrome/enlarged vestibular aqueducts.

No FOXI1 mutations were present in bilateral deafness patients with inner ear malformation.
Title: Screening of SLC26A4, FOXI1, KCNJ10, and GJB2 in bilateral deafness patients with inner ear malformation.

SLC26A4, FOXI1 and KCNJ10 are not major determinants in unilateral deafness and enlarged vestibular aqueduct
Title: Screening of SLC26A4, FOXI1 and KCNJ10 genes in unilateral hearing impairment with ipsilateral enlarged vestibular aqueduct.

Data suggestthat Foxi1 is necessary for expression of at least four subunits in three different epithelia and most likely is a major determinant for proper assembly of a functional vacuolar H(+)-ATPase complex at these locations.
Title: The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney and epididymis.

The following FOXI1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXI1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16196	NM_144769.3 Latest version!	Homo sapiens forkhead box I1 (FOXI1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu18867	NM_012188.5 Latest version!	Homo sapiens forkhead box I1 (FOXI1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu18867	NM_012188.4	Homo sapiens forkhead box I1 (FOXI1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu16196	NM_144769.2	Homo sapiens forkhead box I1 (FOXI1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FOXI1 ( NM_144769.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_658982.1 Homo sapiens forkhead box I1 (FOXI1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16196
Clone ID Related Accession (Same CDS sequence)	NM_144769.2 , NM_144769.3
Accession Version	NM_144769.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 852bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	forkhead box protein I1 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC029778.1 and AC008660.5. On Mar 15, 2007 this sequence version replaced NM_144769.1. Transcript Variant: This variant (2) lacks an alternate in-frame coding segment compared to variant 1, resulting in an isoform (b) that lacks an internal portion compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC029778.1, AY707089.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCCT TCGACCTGCC GGCGCCCTCC CCACCTCGCT GCAGCCCCCA GTTCCCCAGC 
ATCGGCCAGG AGCCCCCCGA GATGAACCTC TACTATGAGA ACTTCTTCCA CCCACAGGGC 
GTGCCCAGCC CTCAGCGGCC CTCCTTCGAG GGGGGCGGCG AGTATGGGGC CACCCCCAAC 
CCCTACCTCT GGTTCAACGG GCCCACCATG ACCCCGCCAC CCTACCTGCC CGGCCCCAAC 
GCCAGCCCCT TCCTGCCCCA GGCCTATGGA GTGCAGAGGC CGCTGCTGCC CAGCGTGTCG 
GGGCTTGGGG GGAGCGACCT GGGCTGGCTG CCCATCCCCT CGCAGGAGGA GCTGATGAAG 
CTGGTGCGGC CACCCTATTC CTACTCGGCT CTCATCGCCA TGGCCATCCA CGGGGCACCC 
GACAAGCGCC TCACTCTCAG CCAGATCTAC CAGTACGTGG CCGACAACTT CCCCTTCTAC 
AACAAGAGCA AGGCCGGCTG GCAGAACTCC ATCCGCCACA ACCTGTCGCT CAACGACTGC 
TTCAAGAAGG TGCCCCGCGA CGAGGACGAC CCGGCCTATG TGAGCGGGGG GAGCCCCACG 
AGCCACCCCT TGGTCACACC AGGACTGAGC CCTGAGCCCA GTGACAAGAC GGGGCAGAAC 
TCACTGACCT TCAACTCCTT CTCCCCGCTC ACCAACCTCA GCAACCACAG CGGTGGGGGT 
GACTGGGCGA ACCCCATGCC CACCAACATG CTCAGCTATG GAGGATCTGT GCTCAGCCAA 
TTCAGCCCTC ACTTCTACAA CAGTGTCAAC ACCAGTGGTG TCCTCTACCC CAGGGAGGGC 
ACCGAGGTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_658982.1
CDS	46..897
Translation	MSSFDLPAPSPPRCSPQFPSIGQEPPEMNLYYENFFHPQGVPSPQRPSFEGGGEYGATPNPYLWFNGPTMTPPPYLPGPNASPFLPQAYGVQRPLLPSVSGLGGSDLGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPAYVSGGSPTSHPLVTPGLSPEPSDKTGQNSLTFNSFSPLTNLSNHSGGGDWANPMPTNMLSYGGSVLSQFSPHFYNSVNTSGVLYPREGTEV

Target ORF information:

RefSeq Version	NM_144769.2
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box I1 (FOXI1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144769.2

ORF Insert Sequence:

ATGAGCTCCT TCGACCTGCC GGCGCCCTCC CCACCTCGCT GCAGCCCCCA GTTCCCCAGC 
ATCGGCCAGG AGCCCCCCGA GATGAACCTC TACTATGAGA ACTTCTTCCA CCCACAGGGC 
GTGCCCAGCC CTCAGCGGCC CTCCTTCGAG GGGGGCGGCG AGTATGGGGC CACCCCCAAC 
CCCTACCTCT GGTTCAACGG GCCCACCATG ACCCCGCCAC CCTACCTGCC CGGCCCCAAC 
GCCAGCCCCT TCCTGCCCCA GGCCTATGGA GTGCAGAGGC CGCTGCTGCC CAGCGTGTCG 
GGGCTTGGGG GGAGCGACCT GGGCTGGCTG CCCATCCCCT CGCAGGAGGA GCTGATGAAG 
CTGGTGCGGC CACCCTATTC CTACTCGGCT CTCATCGCCA TGGCCATCCA CGGGGCACCC 
GACAAGCGCC TCACTCTCAG CCAGATCTAC CAGTACGTGG CCGACAACTT CCCCTTCTAC 
AACAAGAGCA AGGCCGGCTG GCAGAACTCC ATCCGCCACA ACCTGTCGCT CAACGACTGC 
TTCAAGAAGG TGCCCCGCGA CGAGGACGAC CCGGCCTATG TGAGCGGGGG GAGCCCCACG 
AGCCACCCCT TGGTCACACC AGGACTGAGC CCTGAGCCCA GTGACAAGAC GGGGCAGAAC 
TCACTGACCT TCAACTCCTT CTCCCCGCTC ACCAACCTCA GCAACCACAG CGGTGGGGGT 
GACTGGGCGA ACCCCATGCC CACCAACATG CTCAGCTATG GAGGATCTGT GCTCAGCCAA 
TTCAGCCCTC ACTTCTACAA CAGTGTCAAC ACCAGTGGTG TCCTCTACCC CAGGGAGGGC 
ACCGAGGTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FOXI1 ( NM_144769.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_658982.1 Homo sapiens forkhead box I1 (FOXI1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16196
Clone ID Related Accession (Same CDS sequence)	NM_144769.2 , NM_144769.3
Accession Version	NM_144769.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 852bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	forkhead box protein I1 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008660.5 and BC029778.1. On Jun 1, 2019 this sequence version replaced NM_144769.2. Transcript Variant: This variant (2) lacks an alternate in-frame coding segment compared to variant 1, resulting in an isoform (b) that lacks an internal portion compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC029778.1, AY707089.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCCT TCGACCTGCC GGCGCCCTCC CCACCTCGCT GCAGCCCCCA GTTCCCCAGC 
ATCGGCCAGG AGCCCCCCGA GATGAACCTC TACTATGAGA ACTTCTTCCA CCCACAGGGC 
GTGCCCAGCC CTCAGCGGCC CTCCTTCGAG GGGGGCGGCG AGTATGGGGC CACCCCCAAC 
CCCTACCTCT GGTTCAACGG GCCCACCATG ACCCCGCCAC CCTACCTGCC CGGCCCCAAC 
GCCAGCCCCT TCCTGCCCCA GGCCTATGGA GTGCAGAGGC CGCTGCTGCC CAGCGTGTCG 
GGGCTTGGGG GGAGCGACCT GGGCTGGCTG CCCATCCCCT CGCAGGAGGA GCTGATGAAG 
CTGGTGCGGC CACCCTATTC CTACTCGGCT CTCATCGCCA TGGCCATCCA CGGGGCACCC 
GACAAGCGCC TCACTCTCAG CCAGATCTAC CAGTACGTGG CCGACAACTT CCCCTTCTAC 
AACAAGAGCA AGGCCGGCTG GCAGAACTCC ATCCGCCACA ACCTGTCGCT CAACGACTGC 
TTCAAGAAGG TGCCCCGCGA CGAGGACGAC CCGGCCTATG TGAGCGGGGG GAGCCCCACG 
AGCCACCCCT TGGTCACACC AGGACTGAGC CCTGAGCCCA GTGACAAGAC GGGGCAGAAC 
TCACTGACCT TCAACTCCTT CTCCCCGCTC ACCAACCTCA GCAACCACAG CGGTGGGGGT 
GACTGGGCGA ACCCCATGCC CACCAACATG CTCAGCTATG GAGGATCTGT GCTCAGCCAA 
TTCAGCCCTC ACTTCTACAA CAGTGTCAAC ACCAGTGGTG TCCTCTACCC CAGGGAGGGC 
ACCGAGGTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_658982.1
CDS	62..913
Translation	MSSFDLPAPSPPRCSPQFPSIGQEPPEMNLYYENFFHPQGVPSPQRPSFEGGGEYGATPNPYLWFNGPTMTPPPYLPGPNASPFLPQAYGVQRPLLPSVSGLGGSDLGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPAYVSGGSPTSHPLVTPGLSPEPSDKTGQNSLTFNSFSPLTNLSNHSGGGDWANPMPTNMLSYGGSVLSQFSPHFYNSVNTSGVLYPREGTEV

Target ORF information:

RefSeq Version	NM_144769.3
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box I1 (FOXI1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144769.3

ORF Insert Sequence:

ATGAGCTCCT TCGACCTGCC GGCGCCCTCC CCACCTCGCT GCAGCCCCCA GTTCCCCAGC 
ATCGGCCAGG AGCCCCCCGA GATGAACCTC TACTATGAGA ACTTCTTCCA CCCACAGGGC 
GTGCCCAGCC CTCAGCGGCC CTCCTTCGAG GGGGGCGGCG AGTATGGGGC CACCCCCAAC 
CCCTACCTCT GGTTCAACGG GCCCACCATG ACCCCGCCAC CCTACCTGCC CGGCCCCAAC 
GCCAGCCCCT TCCTGCCCCA GGCCTATGGA GTGCAGAGGC CGCTGCTGCC CAGCGTGTCG 
GGGCTTGGGG GGAGCGACCT GGGCTGGCTG CCCATCCCCT CGCAGGAGGA GCTGATGAAG 
CTGGTGCGGC CACCCTATTC CTACTCGGCT CTCATCGCCA TGGCCATCCA CGGGGCACCC 
GACAAGCGCC TCACTCTCAG CCAGATCTAC CAGTACGTGG CCGACAACTT CCCCTTCTAC 
AACAAGAGCA AGGCCGGCTG GCAGAACTCC ATCCGCCACA ACCTGTCGCT CAACGACTGC 
TTCAAGAAGG TGCCCCGCGA CGAGGACGAC CCGGCCTATG TGAGCGGGGG GAGCCCCACG 
AGCCACCCCT TGGTCACACC AGGACTGAGC CCTGAGCCCA GTGACAAGAC GGGGCAGAAC 
TCACTGACCT TCAACTCCTT CTCCCCGCTC ACCAACCTCA GCAACCACAG CGGTGGGGGT 
GACTGGGCGA ACCCCATGCC CACCAACATG CTCAGCTATG GAGGATCTGT GCTCAGCCAA 
TTCAGCCCTC ACTTCTACAA CAGTGTCAAC ACCAGTGGTG TCCTCTACCC CAGGGAGGGC 
ACCGAGGTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FOXI1 ( NM_012188.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036320.2 Homo sapiens forkhead box I1 (FOXI1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18867
Clone ID Related Accession (Same CDS sequence)	NM_012188.4 , NM_012188.5
Accession Version	NM_012188.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1137bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-29
Organism	Homo sapiens(human)
Product	forkhead box protein I1 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC029778.1 and AC008660.5. This sequence is a reference standard in the RefSeqGene project. On Mar 15, 2007 this sequence version replaced NM_012188.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L13203.1, AK292176.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCCT TCGACCTGCC GGCGCCCTCC CCACCTCGCT GCAGCCCCCA GTTCCCCAGC 
ATCGGCCAGG AGCCCCCCGA GATGAACCTC TACTATGAGA ACTTCTTCCA CCCACAGGGC 
GTGCCCAGCC CTCAGCGGCC CTCCTTCGAG GGGGGCGGCG AGTATGGGGC CACCCCCAAC 
CCCTACCTCT GGTTCAACGG GCCCACCATG ACCCCGCCAC CCTACCTGCC CGGCCCCAAC 
GCCAGCCCCT TCCTGCCCCA GGCCTATGGA GTGCAGAGGC CGCTGCTGCC CAGCGTGTCG 
GGGCTTGGGG GGAGCGACCT GGGCTGGCTG CCCATCCCCT CGCAGGAGGA GCTGATGAAG 
CTGGTGCGGC CACCCTATTC CTACTCGGCT CTCATCGCCA TGGCCATCCA CGGGGCACCC 
GACAAGCGCC TCACTCTCAG CCAGATCTAC CAGTACGTGG CCGACAACTT CCCCTTCTAC 
AACAAGAGCA AGGCCGGCTG GCAGAACTCC ATCCGCCACA ACCTGTCGCT CAACGACTGC 
TTCAAGAAGG TGCCCCGCGA CGAGGACGAC CCGGGCAAAG GGAATTACTG GACCCTGGAC 
CCCAACTGTG AGAAAATGTT CGACAATGGA AATTTCCGCA GGAAAAGGAA GAGAAAATCA 
GATGTTTCCT CTAGCACAGC CTCCTTGGCC TTAGAGAAGA CAGAGAGCAG TCTCCCGGTG 
GACAGCCCCA AGACCACGGA GCCTCAGGAC ATCTTGGATG GAGCCTCACC AGGGGGCACC 
ACCAGCTCCC CAGAGAAGCG GCCCTCCCCT CCCCCATCAG GCGCCCCTTG CCTTAACAGC 
TTCCTTTCCT CTATGACAGC CTATGTGAGC GGGGGGAGCC CCACGAGCCA CCCCTTGGTC 
ACACCAGGAC TGAGCCCTGA GCCCAGTGAC AAGACGGGGC AGAACTCACT GACCTTCAAC 
TCCTTCTCCC CGCTCACCAA CCTCAGCAAC CACAGCGGTG GGGGTGACTG GGCGAACCCC 
ATGCCCACCA ACATGCTCAG CTATGGAGGA TCTGTGCTCA GCCAATTCAG CCCTCACTTC 
TACAACAGTG TCAACACCAG TGGTGTCCTC TACCCCAGGG AGGGCACCGA GGTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036320.2
CDS	46..1182
Translation	MSSFDLPAPSPPRCSPQFPSIGQEPPEMNLYYENFFHPQGVPSPQRPSFEGGGEYGATPNPYLWFNGPTMTPPPYLPGPNASPFLPQAYGVQRPLLPSVSGLGGSDLGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSTASLALEKTESSLPVDSPKTTEPQDILDGASPGGTTSSPEKRPSPPPSGAPCLNSFLSSMTAYVSGGSPTSHPLVTPGLSPEPSDKTGQNSLTFNSFSPLTNLSNHSGGGDWANPMPTNMLSYGGSVLSQFSPHFYNSVNTSGVLYPREGTEV

Target ORF information:

RefSeq Version	NM_012188.4
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box I1 (FOXI1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012188.4

ORF Insert Sequence:

ATGAGCTCCT TCGACCTGCC GGCGCCCTCC CCACCTCGCT GCAGCCCCCA GTTCCCCAGC 
ATCGGCCAGG AGCCCCCCGA GATGAACCTC TACTATGAGA ACTTCTTCCA CCCACAGGGC 
GTGCCCAGCC CTCAGCGGCC CTCCTTCGAG GGGGGCGGCG AGTATGGGGC CACCCCCAAC 
CCCTACCTCT GGTTCAACGG GCCCACCATG ACCCCGCCAC CCTACCTGCC CGGCCCCAAC 
GCCAGCCCCT TCCTGCCCCA GGCCTATGGA GTGCAGAGGC CGCTGCTGCC CAGCGTGTCG 
GGGCTTGGGG GGAGCGACCT GGGCTGGCTG CCCATCCCCT CGCAGGAGGA GCTGATGAAG 
CTGGTGCGGC CACCCTATTC CTACTCGGCT CTCATCGCCA TGGCCATCCA CGGGGCACCC 
GACAAGCGCC TCACTCTCAG CCAGATCTAC CAGTACGTGG CCGACAACTT CCCCTTCTAC 
AACAAGAGCA AGGCCGGCTG GCAGAACTCC ATCCGCCACA ACCTGTCGCT CAACGACTGC 
TTCAAGAAGG TGCCCCGCGA CGAGGACGAC CCGGGCAAAG GGAATTACTG GACCCTGGAC 
CCCAACTGTG AGAAAATGTT CGACAATGGA AATTTCCGCA GGAAAAGGAA GAGAAAATCA 
GATGTTTCCT CTAGCACAGC CTCCTTGGCC TTAGAGAAGA CAGAGAGCAG TCTCCCGGTG 
GACAGCCCCA AGACCACGGA GCCTCAGGAC ATCTTGGATG GAGCCTCACC AGGGGGCACC 
ACCAGCTCCC CAGAGAAGCG GCCCTCCCCT CCCCCATCAG GCGCCCCTTG CCTTAACAGC 
TTCCTTTCCT CTATGACAGC CTATGTGAGC GGGGGGAGCC CCACGAGCCA CCCCTTGGTC 
ACACCAGGAC TGAGCCCTGA GCCCAGTGAC AAGACGGGGC AGAACTCACT GACCTTCAAC 
TCCTTCTCCC CGCTCACCAA CCTCAGCAAC CACAGCGGTG GGGGTGACTG GGCGAACCCC 
ATGCCCACCA ACATGCTCAG CTATGGAGGA TCTGTGCTCA GCCAATTCAG CCCTCACTTC 
TACAACAGTG TCAACACCAG TGGTGTCCTC TACCCCAGGG AGGGCACCGA GGTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FOXI1 ( NM_012188.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_036320.2 Homo sapiens forkhead box I1 (FOXI1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18867
Clone ID Related Accession (Same CDS sequence)	NM_012188.4 , NM_012188.5
Accession Version	NM_012188.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1137bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	forkhead box protein I1 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008660.5 and BC029778.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_012188.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292176.1, L13203.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000306268.8/ ENSP00000304286.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCTCCT TCGACCTGCC GGCGCCCTCC CCACCTCGCT GCAGCCCCCA GTTCCCCAGC 
ATCGGCCAGG AGCCCCCCGA GATGAACCTC TACTATGAGA ACTTCTTCCA CCCACAGGGC 
GTGCCCAGCC CTCAGCGGCC CTCCTTCGAG GGGGGCGGCG AGTATGGGGC CACCCCCAAC 
CCCTACCTCT GGTTCAACGG GCCCACCATG ACCCCGCCAC CCTACCTGCC CGGCCCCAAC 
GCCAGCCCCT TCCTGCCCCA GGCCTATGGA GTGCAGAGGC CGCTGCTGCC CAGCGTGTCG 
GGGCTTGGGG GGAGCGACCT GGGCTGGCTG CCCATCCCCT CGCAGGAGGA GCTGATGAAG 
CTGGTGCGGC CACCCTATTC CTACTCGGCT CTCATCGCCA TGGCCATCCA CGGGGCACCC 
GACAAGCGCC TCACTCTCAG CCAGATCTAC CAGTACGTGG CCGACAACTT CCCCTTCTAC 
AACAAGAGCA AGGCCGGCTG GCAGAACTCC ATCCGCCACA ACCTGTCGCT CAACGACTGC 
TTCAAGAAGG TGCCCCGCGA CGAGGACGAC CCGGGCAAAG GGAATTACTG GACCCTGGAC 
CCCAACTGTG AGAAAATGTT CGACAATGGA AATTTCCGCA GGAAAAGGAA GAGAAAATCA 
GATGTTTCCT CTAGCACAGC CTCCTTGGCC TTAGAGAAGA CAGAGAGCAG TCTCCCGGTG 
GACAGCCCCA AGACCACGGA GCCTCAGGAC ATCTTGGATG GAGCCTCACC AGGGGGCACC 
ACCAGCTCCC CAGAGAAGCG GCCCTCCCCT CCCCCATCAG GCGCCCCTTG CCTTAACAGC 
TTCCTTTCCT CTATGACAGC CTATGTGAGC GGGGGGAGCC CCACGAGCCA CCCCTTGGTC 
ACACCAGGAC TGAGCCCTGA GCCCAGTGAC AAGACGGGGC AGAACTCACT GACCTTCAAC 
TCCTTCTCCC CGCTCACCAA CCTCAGCAAC CACAGCGGTG GGGGTGACTG GGCGAACCCC 
ATGCCCACCA ACATGCTCAG CTATGGAGGA TCTGTGCTCA GCCAATTCAG CCCTCACTTC 
TACAACAGTG TCAACACCAG TGGTGTCCTC TACCCCAGGG AGGGCACCGA GGTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036320.2
CDS	62..1198
Translation	MSSFDLPAPSPPRCSPQFPSIGQEPPEMNLYYENFFHPQGVPSPQRPSFEGGGEYGATPNPYLWFNGPTMTPPPYLPGPNASPFLPQAYGVQRPLLPSVSGLGGSDLGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSTASLALEKTESSLPVDSPKTTEPQDILDGASPGGTTSSPEKRPSPPPSGAPCLNSFLSSMTAYVSGGSPTSHPLVTPGLSPEPSDKTGQNSLTFNSFSPLTNLSNHSGGGDWANPMPTNMLSYGGSVLSQFSPHFYNSVNTSGVLYPREGTEV

Target ORF information:

RefSeq Version	NM_012188.5
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box I1 (FOXI1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012188.5

ORF Insert Sequence:

ATGAGCTCCT TCGACCTGCC GGCGCCCTCC CCACCTCGCT GCAGCCCCCA GTTCCCCAGC 
ATCGGCCAGG AGCCCCCCGA GATGAACCTC TACTATGAGA ACTTCTTCCA CCCACAGGGC 
GTGCCCAGCC CTCAGCGGCC CTCCTTCGAG GGGGGCGGCG AGTATGGGGC CACCCCCAAC 
CCCTACCTCT GGTTCAACGG GCCCACCATG ACCCCGCCAC CCTACCTGCC CGGCCCCAAC 
GCCAGCCCCT TCCTGCCCCA GGCCTATGGA GTGCAGAGGC CGCTGCTGCC CAGCGTGTCG 
GGGCTTGGGG GGAGCGACCT GGGCTGGCTG CCCATCCCCT CGCAGGAGGA GCTGATGAAG 
CTGGTGCGGC CACCCTATTC CTACTCGGCT CTCATCGCCA TGGCCATCCA CGGGGCACCC 
GACAAGCGCC TCACTCTCAG CCAGATCTAC CAGTACGTGG CCGACAACTT CCCCTTCTAC 
AACAAGAGCA AGGCCGGCTG GCAGAACTCC ATCCGCCACA ACCTGTCGCT CAACGACTGC 
TTCAAGAAGG TGCCCCGCGA CGAGGACGAC CCGGGCAAAG GGAATTACTG GACCCTGGAC 
CCCAACTGTG AGAAAATGTT CGACAATGGA AATTTCCGCA GGAAAAGGAA GAGAAAATCA 
GATGTTTCCT CTAGCACAGC CTCCTTGGCC TTAGAGAAGA CAGAGAGCAG TCTCCCGGTG 
GACAGCCCCA AGACCACGGA GCCTCAGGAC ATCTTGGATG GAGCCTCACC AGGGGGCACC 
ACCAGCTCCC CAGAGAAGCG GCCCTCCCCT CCCCCATCAG GCGCCCCTTG CCTTAACAGC 
TTCCTTTCCT CTATGACAGC CTATGTGAGC GGGGGGAGCC CCACGAGCCA CCCCTTGGTC 
ACACCAGGAC TGAGCCCTGA GCCCAGTGAC AAGACGGGGC AGAACTCACT GACCTTCAAC 
TCCTTCTCCC CGCTCACCAA CCTCAGCAAC CACAGCGGTG GGGGTGACTG GGCGAACCCC 
ATGCCCACCA ACATGCTCAG CTATGGAGGA TCTGTGCTCA GCCAATTCAG CCCTCACTTC 
TACAACAGTG TCAACACCAG TGGTGTCCTC TACCCCAGGG AGGGCACCGA GGTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Acidosis and Deafness in Patients with Recessive Mutations in FOXI1.
Journal of the American Society of Nephrology : JASN(2017 Dec)
Enerb?ck S,Nilsson D,Edwards N,Heglind M,Alkanderi S,Ashton E,Deeb A,Kokash FEB,Bakhsh ARA,Van't Hoff W,Walsh SB,D'Arco F,Daryadel A,Bourgeois S,Wagner CA,Kleta R,Bockenhauer D,Sayer JA

miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/?-catenin signaling in the development of gastric cancer.
Cell death & disease8(3)e2714(2017 Mar)
Sun R,Liu Z,Tong D,Yang Y,Guo B,Wang X,Zhao L,Huang C

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Nature communications54020(2014 Jun)
Navarini AA,Simpson MA,Weale M,Knight J,Carlavan I,Reiniche P,Burden DA,Layton A,Bataille V,Allen M,Pleass R,Pink A,Creamer D,English J,Munn S,Walton S,,Willis C,D?ret S,Voegel JJ,Spector T,Smith CH,Trembath RC,Barker JN

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FOXI1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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