FKBP4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FKBP4
Entrez Gene ID	2288
Full Name	FK506 binding protein 4
Synonyms	FKBP51,FKBP52,FKBP59,HBI,Hsp56,PPIase,p52
General protein information	Preferred Names FK506 binding protein 4 Names peptidyl-prolyl cis-trans isomerase FKBP4 FK506 binding protein 4, 59kDa HSP binding immunophilin T-cell FK506-binding protein, 59kD peptidylprolyl cis-trans isomerase rotamase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.33
Summary	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008].
Disorder MIM:	600611

mRNA and Protein(s)

mRNA	Protein	Name
NM_002014.4	NP_002005.1	peptidyl-prolyl cis-trans isomerase FKBP4
NM_002014.3	NP_002005.1	peptidyl-prolyl cis-trans isomerase FKBP4
XM_011520929.2	XP_011519231.1	peptidyl-prolyl cis-trans isomerase FKBP4 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FKBP4	NP_001029494.1
Arabidopsis thaliana (thale cress)	ROF1	NP_189160.3
Pan troglodytes (chimpanzee)	FKBP4	XP_508927.3
	FKBP4	XP_001098079.2
Canis lupus familiaris (dog)	FKBP4	XP_534923.1
Mus musculus (house mouse)	Fkbp4	NP_034349.1
Rattus norvegicus (Norway rat)	Fkbp4	NP_001178792.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009347	XP_559833.2
Oryza sativa (rice)	Os02g0491400	NP_001046873.1
Oryza sativa (rice)	Os08g0525600	NP_001062292.1
Homo sapiens (human)	FKBP4	NP_002005.1
Gallus gallus (chicken)	FKBP4	NP_001006250.1
Danio rerio (zebrafish)	fkbp4	NP_958877.1
Drosophila melanogaster (fruit fly)	FKBP59	NP_524895.2
Oryza sativa (rice)	Os04g0352400	NP_001052535.1
Caenorhabditis elegans (roundworm)	fkb-6	NP_508026.1

Gene Ontology
Bibliography

Related articles in PubMed

USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.
Luo K, Li Y, Yin Y, Li L, Wu C, Chen Y, Nowsheen S, Hu Q, Zhang L, Lou Z, Yuan J
The EMBO journal36(10)1434-1446(2017 05)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52.
Joshi JB, Patel D, Morton DJ, Sharma P, Zou J, Hewa Bostanthirige D, Gorantla Y, Nagappan P, Komaragiri SK, Sivils JC, Xie H, Palaniappan R, Wang G, Cox MB, Chaudhary J
Molecular oncology11(4)337-357(2017 Apr)

Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4.
Joshi NR, Miyadahira EH, Afshar Y, Jeong JW, Young SL, Lessey BA, Serafini PC, Fazleabas AT
The Journal of clinical endocrinology and metabolism102(1)141-149(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP's capability to dephosphorylate AKT.
Title: USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.

ID4 selectively regulates AR activity through direct interaction with FKBP52.
Title: Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52.

Low expression of FKBP4 is associated with Progesterone Resistance in Endometriosis.
Title: Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4.

FKBP52 could be abnormally released from NFTs negative neurons in AD brains in correlation with the early pathologic Tau-D(421) neuronal accumulation.
Title: Caspase-cleaved Tau-D(421) is colocalized with the immunophilin FKBP52 in the autophagy-endolysosomal system of Alzheimer's disease neurons.

Results provide a molecular mechanism by which FKBP52 modulates telomerase activity by promoting dynein-dynactin-dependent nuclear import of hTERT.
Title: Hsp90-binding immunophilin FKBP52 modulates telomerase activity by promoting the cytoplasmic retrotransport of hTERT.

The following FKBP4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FKBP4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16360	NM_002014.4 Latest version!	Homo sapiens FKBP prolyl isomerase 4 (FKBP4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu57787	XM_011520929.2 Latest version!	Homo sapiens FKBP prolyl isomerase 4 (FKBP4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
View Old Accession Versions >>
OHu16360	NM_002014.3	Homo sapiens FK506 binding protein 4 (FKBP4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FKBP4 ( NM_002014.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002005.1 Homo sapiens FKBP prolyl isomerase 4 (FKBP4), mRNA.

Price & Availability↑

CloneID	OHu16360
Clone ID Related Accession (Same CDS sequence)	NM_002014.4 , NM_002014.3
Accession Version	NM_002014.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1380bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	peptidyl-prolyl cis-trans isomerase FKBP4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA392592.1, BC001786.1, BU685040.1, AK024694.1, BQ083177.1 and BQ446607.1. On Nov 22, 2018 this sequence version replaced NM_002014.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.159743.1, SRR1803615.213037.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000001008.6/ ENSP00000001008.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACAGCCG AGGAGATGAA GGCGACCGAG AGCGGGGCGC AGTCGGCGCC GCTGCCCATG 
GAGGGAGTGG ACATCAGCCC CAAACAGGAC GAAGGCGTGC TGAAGGTCAT CAAGAGAGAG 
GGCACAGGTA CAGAGATGCC CATGATTGGG GACCGAGTCT TTGTCCACTA CACTGGCTGG 
CTATTAGATG GCACAAAGTT TGACTCCAGT CTGGATCGCA AGGACAAATT CTCCTTTGAC 
CTGGGAAAAG GGGAGGTCAT CAAGGCTTGG GACATTGCCA TAGCCACCAT GAAGGTGGGG 
GAGGTGTGCC ACATCACCTG CAAACCAGAA TATGCCTACG GTTCAGCAGG CAGTCCTCCA 
AAGATTCCCC CCAATGCCAC GCTTGTATTT GAGGTGGAGT TGTTTGAGTT TAAGGGAGAA 
GATCTGACGG AAGAGGAAGA TGGCGGAATC ATTCGCAGAA TACAGACTCG CGGTGAAGGC 
TATGCTAAGC CCAATGAGGG TGCTATCGTG GAGGTTGCAC TGGAAGGGTA CTACAAGGAC 
AAGCTCTTTG ACCAGCGGGA GCTCCGCTTT GAGATTGGCG AGGGGGAGAA CCTGGATCTG 
CCTTATGGTC TGGAGAGGGC CATTCAGCGC ATGGAGAAAG GAGAACATTC CATCGTGTAC 
CTCAAGCCCA GCTATGCTTT TGGCAGTGTT GGGAAGGAAA AGTTCCAAAT CCCACCAAAT 
GCTGAGCTGA AATATGAATT ACACCTCAAG AGTTTTGAAA AGGCCAAGGA GTCTTGGGAG 
ATGAATTCAG AAGAGAAGCT GGAACAGAGC ACCATAGTGA AAGAGCGGGG CACTGTGTAC 
TTCAAGGAAG GTAAATACAA GCAAGCTTTA CTACAGTATA AGAAGATCGT GTCTTGGCTG 
GAATATGAGT CTAGTTTTTC CAATGAGGAA GCACAGAAAG CACAGGCCCT TCGACTGGCC 
TCTCACCTCA ACCTGGCCAT GTGTCATCTG AAACTACAGG CCTTCTCTGC TGCCATTGAA 
AGCTGTAACA AGGCCCTAGA ACTGGACAGC AACAACGAGA AGGGCCTCTT CCGCCGGGGA 
GAGGCCCACC TGGCCGTGAA TGACTTTGAA CTGGCACGGG CTGATTTCCA GAAGGTCCTG 
CAGCTCTACC CCAACAACAA AGCCGCCAAG ACCCAGCTGG CTGTGTGCCA GCAGCGGATC 
CGAAGGCAGC TTGCCCGGGA GAAGAAGCTC TATGCCAATA TGTTTGAGAG GCTGGCTGAG 
GAGGAGAACA AGGCCAAGGC AGAGGCTTCC TCAGGAGACC ATCCCACTGA CACAGAGATG 
AAGGAGGAGC AGAAGAGCAA CACGGCAGGG AGCCAGTCTC AGGTGGAGAC AGAAGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002005.1
CDS	171..1550
Translation	MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA

Target ORF information:

RefSeq Version	NM_002014.4
Organism	Homo sapiens(human)
Definition	Homo sapiens FKBP prolyl isomerase 4 (FKBP4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002014.4

ORF Insert Sequence:

ATGACAGCCG AGGAGATGAA GGCGACCGAG AGCGGGGCGC AGTCGGCGCC GCTGCCCATG 
GAGGGAGTGG ACATCAGCCC CAAACAGGAC GAAGGCGTGC TGAAGGTCAT CAAGAGAGAG 
GGCACAGGTA CAGAGATGCC CATGATTGGG GACCGAGTCT TTGTCCACTA CACTGGCTGG 
CTATTAGATG GCACAAAGTT TGACTCCAGT CTGGATCGCA AGGACAAATT CTCCTTTGAC 
CTGGGAAAAG GGGAGGTCAT CAAGGCTTGG GACATTGCCA TAGCCACCAT GAAGGTGGGG 
GAGGTGTGCC ACATCACCTG CAAACCAGAA TATGCCTACG GTTCAGCAGG CAGTCCTCCA 
AAGATTCCCC CCAATGCCAC GCTTGTATTT GAGGTGGAGT TGTTTGAGTT TAAGGGAGAA 
GATCTGACGG AAGAGGAAGA TGGCGGAATC ATTCGCAGAA TACAGACTCG CGGTGAAGGC 
TATGCTAAGC CCAATGAGGG TGCTATCGTG GAGGTTGCAC TGGAAGGGTA CTACAAGGAC 
AAGCTCTTTG ACCAGCGGGA GCTCCGCTTT GAGATTGGCG AGGGGGAGAA CCTGGATCTG 
CCTTATGGTC TGGAGAGGGC CATTCAGCGC ATGGAGAAAG GAGAACATTC CATCGTGTAC 
CTCAAGCCCA GCTATGCTTT TGGCAGTGTT GGGAAGGAAA AGTTCCAAAT CCCACCAAAT 
GCTGAGCTGA AATATGAATT ACACCTCAAG AGTTTTGAAA AGGCCAAGGA GTCTTGGGAG 
ATGAATTCAG AAGAGAAGCT GGAACAGAGC ACCATAGTGA AAGAGCGGGG CACTGTGTAC 
TTCAAGGAAG GTAAATACAA GCAAGCTTTA CTACAGTATA AGAAGATCGT GTCTTGGCTG 
GAATATGAGT CTAGTTTTTC CAATGAGGAA GCACAGAAAG CACAGGCCCT TCGACTGGCC 
TCTCACCTCA ACCTGGCCAT GTGTCATCTG AAACTACAGG CCTTCTCTGC TGCCATTGAA 
AGCTGTAACA AGGCCCTAGA ACTGGACAGC AACAACGAGA AGGGCCTCTT CCGCCGGGGA 
GAGGCCCACC TGGCCGTGAA TGACTTTGAA CTGGCACGGG CTGATTTCCA GAAGGTCCTG 
CAGCTCTACC CCAACAACAA AGCCGCCAAG ACCCAGCTGG CTGTGTGCCA GCAGCGGATC 
CGAAGGCAGC TTGCCCGGGA GAAGAAGCTC TATGCCAATA TGTTTGAGAG GCTGGCTGAG 
GAGGAGAACA AGGCCAAGGC AGAGGCTTCC TCAGGAGACC ATCCCACTGA CACAGAGATG 
AAGGAGGAGC AGAAGAGCAA CACGGCAGGG AGCCAGTCTC AGGTGGAGAC AGAAGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FKBP4 ( NM_002014.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002005.1 Homo sapiens FK506 binding protein 4 (FKBP4), mRNA.

Price & Availability↑

CloneID	OHu16360
Clone ID Related Accession (Same CDS sequence)	NM_002014.4 , NM_002014.3
Accession Version	NM_002014.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1380bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	peptidyl-prolyl cis-trans isomerase FKBP4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA392592.1, BC001786.1, BU685040.1, AK024694.1, BQ083177.1 and BQ446607.1. On Sep 26, 2008 this sequence version replaced NM_002014.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.213037.1, SRR1660805.58717.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACAGCCG AGGAGATGAA GGCGACCGAG AGCGGGGCGC AGTCGGCGCC GCTGCCCATG 
GAGGGAGTGG ACATCAGCCC CAAACAGGAC GAAGGCGTGC TGAAGGTCAT CAAGAGAGAG 
GGCACAGGTA CAGAGATGCC CATGATTGGG GACCGAGTCT TTGTCCACTA CACTGGCTGG 
CTATTAGATG GCACAAAGTT TGACTCCAGT CTGGATCGCA AGGACAAATT CTCCTTTGAC 
CTGGGAAAAG GGGAGGTCAT CAAGGCTTGG GACATTGCCA TAGCCACCAT GAAGGTGGGG 
GAGGTGTGCC ACATCACCTG CAAACCAGAA TATGCCTACG GTTCAGCAGG CAGTCCTCCA 
AAGATTCCCC CCAATGCCAC GCTTGTATTT GAGGTGGAGT TGTTTGAGTT TAAGGGAGAA 
GATCTGACGG AAGAGGAAGA TGGCGGAATC ATTCGCAGAA TACAGACTCG CGGTGAAGGC 
TATGCTAAGC CCAATGAGGG TGCTATCGTG GAGGTTGCAC TGGAAGGGTA CTACAAGGAC 
AAGCTCTTTG ACCAGCGGGA GCTCCGCTTT GAGATTGGCG AGGGGGAGAA CCTGGATCTG 
CCTTATGGTC TGGAGAGGGC CATTCAGCGC ATGGAGAAAG GAGAACATTC CATCGTGTAC 
CTCAAGCCCA GCTATGCTTT TGGCAGTGTT GGGAAGGAAA AGTTCCAAAT CCCACCAAAT 
GCTGAGCTGA AATATGAATT ACACCTCAAG AGTTTTGAAA AGGCCAAGGA GTCTTGGGAG 
ATGAATTCAG AAGAGAAGCT GGAACAGAGC ACCATAGTGA AAGAGCGGGG CACTGTGTAC 
TTCAAGGAAG GTAAATACAA GCAAGCTTTA CTACAGTATA AGAAGATCGT GTCTTGGCTG 
GAATATGAGT CTAGTTTTTC CAATGAGGAA GCACAGAAAG CACAGGCCCT TCGACTGGCC 
TCTCACCTCA ACCTGGCCAT GTGTCATCTG AAACTACAGG CCTTCTCTGC TGCCATTGAA 
AGCTGTAACA AGGCCCTAGA ACTGGACAGC AACAACGAGA AGGGCCTCTT CCGCCGGGGA 
GAGGCCCACC TGGCCGTGAA TGACTTTGAA CTGGCACGGG CTGATTTCCA GAAGGTCCTG 
CAGCTCTACC CCAACAACAA AGCCGCCAAG ACCCAGCTGG CTGTGTGCCA GCAGCGGATC 
CGAAGGCAGC TTGCCCGGGA GAAGAAGCTC TATGCCAATA TGTTTGAGAG GCTGGCTGAG 
GAGGAGAACA AGGCCAAGGC AGAGGCTTCC TCAGGAGACC ATCCCACTGA CACAGAGATG 
AAGGAGGAGC AGAAGAGCAA CACGGCAGGG AGCCAGTCTC AGGTGGAGAC AGAAGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002005.1
CDS	199..1578
Translation	MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA

Target ORF information:

RefSeq Version	NM_002014.3
Organism	Homo sapiens(human)
Definition	Homo sapiens FK506 binding protein 4 (FKBP4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002014.3

ORF Insert Sequence:

ATGACAGCCG AGGAGATGAA GGCGACCGAG AGCGGGGCGC AGTCGGCGCC GCTGCCCATG 
GAGGGAGTGG ACATCAGCCC CAAACAGGAC GAAGGCGTGC TGAAGGTCAT CAAGAGAGAG 
GGCACAGGTA CAGAGATGCC CATGATTGGG GACCGAGTCT TTGTCCACTA CACTGGCTGG 
CTATTAGATG GCACAAAGTT TGACTCCAGT CTGGATCGCA AGGACAAATT CTCCTTTGAC 
CTGGGAAAAG GGGAGGTCAT CAAGGCTTGG GACATTGCCA TAGCCACCAT GAAGGTGGGG 
GAGGTGTGCC ACATCACCTG CAAACCAGAA TATGCCTACG GTTCAGCAGG CAGTCCTCCA 
AAGATTCCCC CCAATGCCAC GCTTGTATTT GAGGTGGAGT TGTTTGAGTT TAAGGGAGAA 
GATCTGACGG AAGAGGAAGA TGGCGGAATC ATTCGCAGAA TACAGACTCG CGGTGAAGGC 
TATGCTAAGC CCAATGAGGG TGCTATCGTG GAGGTTGCAC TGGAAGGGTA CTACAAGGAC 
AAGCTCTTTG ACCAGCGGGA GCTCCGCTTT GAGATTGGCG AGGGGGAGAA CCTGGATCTG 
CCTTATGGTC TGGAGAGGGC CATTCAGCGC ATGGAGAAAG GAGAACATTC CATCGTGTAC 
CTCAAGCCCA GCTATGCTTT TGGCAGTGTT GGGAAGGAAA AGTTCCAAAT CCCACCAAAT 
GCTGAGCTGA AATATGAATT ACACCTCAAG AGTTTTGAAA AGGCCAAGGA GTCTTGGGAG 
ATGAATTCAG AAGAGAAGCT GGAACAGAGC ACCATAGTGA AAGAGCGGGG CACTGTGTAC 
TTCAAGGAAG GTAAATACAA GCAAGCTTTA CTACAGTATA AGAAGATCGT GTCTTGGCTG 
GAATATGAGT CTAGTTTTTC CAATGAGGAA GCACAGAAAG CACAGGCCCT TCGACTGGCC 
TCTCACCTCA ACCTGGCCAT GTGTCATCTG AAACTACAGG CCTTCTCTGC TGCCATTGAA 
AGCTGTAACA AGGCCCTAGA ACTGGACAGC AACAACGAGA AGGGCCTCTT CCGCCGGGGA 
GAGGCCCACC TGGCCGTGAA TGACTTTGAA CTGGCACGGG CTGATTTCCA GAAGGTCCTG 
CAGCTCTACC CCAACAACAA AGCCGCCAAG ACCCAGCTGG CTGTGTGCCA GCAGCGGATC 
CGAAGGCAGC TTGCCCGGGA GAAGAAGCTC TATGCCAATA TGTTTGAGAG GCTGGCTGAG 
GAGGAGAACA AGGCCAAGGC AGAGGCTTCC TCAGGAGACC ATCCCACTGA CACAGAGATG 
AAGGAGGAGC AGAAGAGCAA CACGGCAGGG AGCCAGTCTC AGGTGGAGAC AGAAGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FKBP4 ( XM_011520929.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011519231.1 Homo sapiens FKBP prolyl isomerase 4 (FKBP4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu57787
Clone ID Related Accession (Same CDS sequence)	XM_011520929.2
Accession Version	XM_011520929.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1245bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	peptidyl-prolyl cis-trans isomerase FKBP4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011520929.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCATGA TTGGGGACCG AGTCTTTGTC CACTACACTG GCTGGCTATT AGATGGCACA 
AAGTTTGACT CCAGTCTGGA TCGCAAGGAC AAATTCTCCT TTGACCTGGG AAAAGGGGAG 
GTCATCAAGG CTTGGGACAT TGCCATAGCC ACCATGAAGG TGGGGGAGGT GTGCCACATC 
ACCTGCAAAC CAGAATATGC CTACGGTTCA GCAGGCAGTC CTCCAAAGAT TCCCCCCAAT 
GCCACGCTTG TATTTGAGGT GGAGTTGTTT GAGTTTAAGG GAGAAGATCT GACGGAAGAG 
GAAGATGGCG GAATCATTCG CAGAATACAG ACTCGCGGTG AAGGCTATGC TAAGCCCAAT 
GAGGGTGCTA TCGTGGAGGT TGCACTGGAA GGGTACTACA AGGACAAGCT CTTTGACCAG 
CGGGAGCTCC GCTTTGAGAT TGGCGAGGGG GAGAACCTGG ATCTGCCTTA TGGTCTGGAG 
AGGGCCATTC AGCGCATGGA GAAAGGAGAA CATTCCATCG TGTACCTCAA GCCCAGCTAT 
GCTTTTGGCA GTGTTGGGAA GGAAAAGTTC CAAATCCCAC CAAATGCTGA GCTGAAATAT 
GAATTACACC TCAAGAGTTT TGAAAAGGCC AAGGAGTCTT GGGAGATGAA TTCAGAAGAG 
AAGCTGGAAC AGAGCACCAT AGTGAAAGAG CGGGGCACTG TGTACTTCAA GGAAGGTAAA 
TACAAGCAAG CTTTACTACA GTATAAGAAG ATCGTGTCTT GGCTGGAATA TGAGTCTAGT 
TTTTCCAATG AGGAAGCACA GAAAGCACAG GCCCTTCGAC TGGCCTCTCA CCTCAACCTG 
GCCATGTGTC ATCTGAAACT ACAGGCCTTC TCTGCTGCCA TTGAAAGCTG TAACAAGGCC 
CTAGAACTGG ACAGCAACAA CGAGAAGGGC CTCTTCCGCC GGGGAGAGGC CCACCTGGCC 
GTGAATGACT TTGAACTGGC ACGGGCTGAT TTCCAGAAGG TCCTGCAGCT CTACCCCAAC 
AACAAAGCCG CCAAGACCCA GCTGGCTGTG TGCCAGCAGC GGATCCGAAG GCAGCTTGCC 
CGGGAGAAGA AGCTCTATGC CAATATGTTT GAGAGGCTGG CTGAGGAGGA GAACAAGGCC 
AAGGCAGAGG CTTCCTCAGG AGACCATCCC ACTGACACAG AGATGAAGGA GGAGCAGAAG 
AGCAACACGG CAGGGAGCCA GTCTCAGGTG GAGACAGAAG CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011519231.1
CDS	1327..2571
Translation	MPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA

Target ORF information:

RefSeq Version	XM_011520929.2
Organism	Homo sapiens(human)
Definition	Homo sapiens FKBP prolyl isomerase 4 (FKBP4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520929.2

ORF Insert Sequence:

ATGCCCATGA TTGGGGACCG AGTCTTTGTC CACTACACTG GCTGGCTATT AGATGGCACA 
AAGTTTGACT CCAGTCTGGA TCGCAAGGAC AAATTCTCCT TTGACCTGGG AAAAGGGGAG 
GTCATCAAGG CTTGGGACAT TGCCATAGCC ACCATGAAGG TGGGGGAGGT GTGCCACATC 
ACCTGCAAAC CAGAATATGC CTACGGTTCA GCAGGCAGTC CTCCAAAGAT TCCCCCCAAT 
GCCACGCTTG TATTTGAGGT GGAGTTGTTT GAGTTTAAGG GAGAAGATCT GACGGAAGAG 
GAAGATGGCG GAATCATTCG CAGAATACAG ACTCGCGGTG AAGGCTATGC TAAGCCCAAT 
GAGGGTGCTA TCGTGGAGGT TGCACTGGAA GGGTACTACA AGGACAAGCT CTTTGACCAG 
CGGGAGCTCC GCTTTGAGAT TGGCGAGGGG GAGAACCTGG ATCTGCCTTA TGGTCTGGAG 
AGGGCCATTC AGCGCATGGA GAAAGGAGAA CATTCCATCG TGTACCTCAA GCCCAGCTAT 
GCTTTTGGCA GTGTTGGGAA GGAAAAGTTC CAAATCCCAC CAAATGCTGA GCTGAAATAT 
GAATTACACC TCAAGAGTTT TGAAAAGGCC AAGGAGTCTT GGGAGATGAA TTCAGAAGAG 
AAGCTGGAAC AGAGCACCAT AGTGAAAGAG CGGGGCACTG TGTACTTCAA GGAAGGTAAA 
TACAAGCAAG CTTTACTACA GTATAAGAAG ATCGTGTCTT GGCTGGAATA TGAGTCTAGT 
TTTTCCAATG AGGAAGCACA GAAAGCACAG GCCCTTCGAC TGGCCTCTCA CCTCAACCTG 
GCCATGTGTC ATCTGAAACT ACAGGCCTTC TCTGCTGCCA TTGAAAGCTG TAACAAGGCC 
CTAGAACTGG ACAGCAACAA CGAGAAGGGC CTCTTCCGCC GGGGAGAGGC CCACCTGGCC 
GTGAATGACT TTGAACTGGC ACGGGCTGAT TTCCAGAAGG TCCTGCAGCT CTACCCCAAC 
AACAAAGCCG CCAAGACCCA GCTGGCTGTG TGCCAGCAGC GGATCCGAAG GCAGCTTGCC 
CGGGAGAAGA AGCTCTATGC CAATATGTTT GAGAGGCTGG CTGAGGAGGA GAACAAGGCC 
AAGGCAGAGG CTTCCTCAGG AGACCATCCC ACTGACACAG AGATGAAGGA GGAGCAGAAG 
AGCAACACGG CAGGGAGCCA GTCTCAGGTG GAGACAGAAG CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.
The EMBO journal36(10)1434-1446(2017 05)
Luo K,Li Y,Yin Y,Li L,Wu C,Chen Y,Nowsheen S,Hu Q,Zhang L,Lou Z,Yuan J

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52.
Molecular oncology11(4)337-357(2017 Apr)
Joshi JB,Patel D,Morton DJ,Sharma P,Zou J,Hewa Bostanthirige D,Gorantla Y,Nagappan P,Komaragiri SK,Sivils JC,Xie H,Palaniappan R,Wang G,Cox MB,Chaudhary J

Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4.
The Journal of clinical endocrinology and metabolism102(1)141-149(2017 Jan)
Joshi NR,Miyadahira EH,Afshar Y,Jeong JW,Young SL,Lessey BA,Serafini PC,Fazleabas AT

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

FKBP4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報