FDX1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FDX1
Entrez Gene ID	2230
Full Name	ferredoxin 1
Synonyms	ADX,FDX,LOH11CR1D
General protein information	Preferred Names ferredoxin 1 Names adrenodoxin, mitochondrial adrenal ferredoxin hepatoredoxin mitochondrial adrenodoxin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q22.3
Summary	This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011].
Disorder MIM:	103260

mRNA and Protein(s)

mRNA	Protein	Name
NM_004109.4	NP_004100.1	adrenodoxin, mitochondrial precursor
NM_004109.5	NP_004100.1	adrenodoxin, mitochondrial precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FDX1	XP_508877.3
	LOC709110	XP_001105034.2
Canis lupus familiaris (dog)	FDX1	XP_005620366.1
Bos taurus (cattle)	FDX1	NP_851354.1
Rattus norvegicus (Norway rat)	Fdx1	NP_058822.1
Danio rerio (zebrafish)	fdx1	XP_001922722.2
Drosophila melanogaster (fruit fly)	CG1319	NP_647889.2
Gallus gallus (chicken)	FDX1	NP_001185597.1
Xenopus tropicalis (tropical clawed frog)	fdx1	XP_002938002.1
Mus musculus (house mouse)	Fdx1	NP_032022.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003212	XP_312921.3
Homo sapiens (human)	FDX1	NP_004100.1

Gene Ontology
Bibliography

Related articles in PubMed

Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin.
Zhu Q, Mak PJ, Tuckey RC, Kincaid JR
Biochemistry56(43)5786-5797(2017 10)

Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.
Peng HM, Auchus RJ
Biochemistry56(17)2282-2293(2017 05)

Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron-Sulfur Cluster Biosynthesis.
Cai K, Tonelli M, Frederick RO, Markley JL
Biochemistry56(3)487-499(2017 01)

Association between CCDC132, FDX1 and TNFSF13 gene polymorphisms and the risk of IgA nephropathy.
Niu D, Ren Y, Xie L, Sun J, Lu W, Hao Y, Zhang Y, Yin A, Li H, Lv J, Li S
Nephrology (Carlton, Vic.)20(12)908-15(2015 Dec)

Genetic polymorphisms in TNFSF13 and FDX1 are associated with IgA nephropathy in the Han Chinese population.
Niu D, Gao Y, Xie L, Sun J, Lu W, Jin G, Hao Y, Zhang Y, Yin A, Geng Y, Zhang W, Chen C, Li S
Human immunology76(11)831-5(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin
Title: Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin.

Data suggest that binding sites between CYP11B1/CYP11B2 and adrenodoxin/ferredoxin-1 exhibit electrostatic interactions at K370 in CYP11B1 and at K366 in CYP11B2 mutant R366K with D79 in adrenodoxin/ferredoxin-1. (CYP11B1 = cytochrome P450 family 11 subfamily B member 1; CYP11B2 = cytochrome P450 family 11 subfamily B member 2)
Title: Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.

FDX1 and FDX2 both bind NFS1 and donate electrons for iron-sulfur cluster biosynthesis.
Title: Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron-Sulfur Cluster Biosynthesis.

Did not find any positive association between FDX1 SNPs and the risk of IgA nephropathy after adjustment for age and sex, but did find a significant and strong correlation with relevant clinical pathological parameters.
Title: Association between CCDC132, FDX1 and TNFSF13 gene polymorphisms and the risk of IgA nephropathy.

TNFSF13 and FDX1 have potential roles in IgAN in the Han Chinese population. This information may be useful in the development of early prognostics for IgAN.
Title: Genetic polymorphisms in TNFSF13 and FDX1 are associated with IgA nephropathy in the Han Chinese population.

The following FDX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FDX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55929	NM_004109.5 Latest version!	Homo sapiens ferredoxin 1 (FDX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu55929	NM_004109.4	Homo sapiens ferredoxin 1 (FDX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FDX1 ( NM_004109.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004100.1 Homo sapiens ferredoxin 1 (FDX1), mRNA.

Price & Availability↑

CloneID	OHu55929
Clone ID Related Accession (Same CDS sequence)	NM_004109.4 , NM_004109.5
Accession Version	NM_004109.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	adrenodoxin, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB459133.1, BC010284.1, CN333249.1 and AA505582.1. On Aug 2, 2011 this sequence version replaced NM_004109.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010284.1, SRR1803617.201753.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCCG CTGGGGGCGC CCGGCTGCTG CGCGCCGCTT CTGCTGTCCT CGGCGGCCCG 
GCCGGCCGGT GGCTGCACCA CGCTGGGTCC CGCGCTGGAT CCAGCGGCCT GCTGAGGAAC 
CGGGGGCCGG GCGGGAGCGC GGAGGCGAGC CGGTCGCTGA GCGTGTCGGC GCGGGCCCGG 
AGCAGCTCAG AAGATAAAAT AACAGTCCAC TTTATAAACC GTGATGGTGA AACATTAACA 
ACCAAAGGAA AAGTTGGTGA TTCTCTGCTA GATGTTGTGG TTGAAAATAA TCTAGATATT 
GATGGCTTTG GTGCATGTGA GGGAACCCTG GCTTGTTCAA CCTGTCACCT CATCTTTGAA 
GATCACATAT ATGAGAAGTT AGATGCAATC ACTGATGAGG AGAATGACAT GCTCGATCTG 
GCATATGGAC TAACAGACAG ATCACGGTTG GGCTGCCAAA TCTGTTTGAC AAAATCTATG 
GACAATATGA CTGTTCGAGT GCCTGAAACA GTGGCTGATG CCAGACAATC CATTGATGTG 
GGCAAGACCT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004100.1
CDS	185..739
Translation	MAAAGGARLLRAASAVLGGPAGRWLHHAGSRAGSSGLLRNRGPGGSAEASRSLSVSARARSSSEDKITVHFINRDGETLTTKGKVGDSLLDVVVENNLDIDGFGACEGTLACSTCHLIFEDHIYEKLDAITDEENDMLDLAYGLTDRSRLGCQICLTKSMDNMTVRVPETVADARQSIDVGKTS

Target ORF information:

RefSeq Version	NM_004109.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ferredoxin 1 (FDX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004109.4

ORF Insert Sequence:

ATGGCTGCCG CTGGGGGCGC CCGGCTGCTG CGCGCCGCTT CTGCTGTCCT CGGCGGCCCG 
GCCGGCCGGT GGCTGCACCA CGCTGGGTCC CGCGCTGGAT CCAGCGGCCT GCTGAGGAAC 
CGGGGGCCGG GCGGGAGCGC GGAGGCGAGC CGGTCGCTGA GCGTGTCGGC GCGGGCCCGG 
AGCAGCTCAG AAGATAAAAT AACAGTCCAC TTTATAAACC GTGATGGTGA AACATTAACA 
ACCAAAGGAA AAGTTGGTGA TTCTCTGCTA GATGTTGTGG TTGAAAATAA TCTAGATATT 
GATGGCTTTG GTGCATGTGA GGGAACCCTG GCTTGTTCAA CCTGTCACCT CATCTTTGAA 
GATCACATAT ATGAGAAGTT AGATGCAATC ACTGATGAGG AGAATGACAT GCTCGATCTG 
GCATATGGAC TAACAGACAG ATCACGGTTG GGCTGCCAAA TCTGTTTGAC AAAATCTATG 
GACAATATGA CTGTTCGAGT GCCTGAAACA GTGGCTGATG CCAGACAATC CATTGATGTG 
GGCAAGACCT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FDX1 ( NM_004109.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004100.1 Homo sapiens ferredoxin 1 (FDX1), mRNA.

Price & Availability↑

CloneID	OHu55929
Clone ID Related Accession (Same CDS sequence)	NM_004109.4 , NM_004109.5
Accession Version	NM_004109.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	adrenodoxin, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB459133.1, BC010284.1, CN333249.1 and AA505582.1. On Nov 22, 2018 this sequence version replaced NM_004109.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010284.1, SRR1803617.201753.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000260270.3/ ENSP00000260270.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGCCG CTGGGGGCGC CCGGCTGCTG CGCGCCGCTT CTGCTGTCCT CGGCGGCCCG 
GCCGGCCGGT GGCTGCACCA CGCTGGGTCC CGCGCTGGAT CCAGCGGCCT GCTGAGGAAC 
CGGGGGCCGG GCGGGAGCGC GGAGGCGAGC CGGTCGCTGA GCGTGTCGGC GCGGGCCCGG 
AGCAGCTCAG AAGATAAAAT AACAGTCCAC TTTATAAACC GTGATGGTGA AACATTAACA 
ACCAAAGGAA AAGTTGGTGA TTCTCTGCTA GATGTTGTGG TTGAAAATAA TCTAGATATT 
GATGGCTTTG GTGCATGTGA GGGAACCCTG GCTTGTTCAA CCTGTCACCT CATCTTTGAA 
GATCACATAT ATGAGAAGTT AGATGCAATC ACTGATGAGG AGAATGACAT GCTCGATCTG 
GCATATGGAC TAACAGACAG ATCACGGTTG GGCTGCCAAA TCTGTTTGAC AAAATCTATG 
GACAATATGA CTGTTCGAGT GCCTGAAACA GTGGCTGATG CCAGACAATC CATTGATGTG 
GGCAAGACCT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004100.1
CDS	174..728
Translation	MAAAGGARLLRAASAVLGGPAGRWLHHAGSRAGSSGLLRNRGPGGSAEASRSLSVSARARSSSEDKITVHFINRDGETLTTKGKVGDSLLDVVVENNLDIDGFGACEGTLACSTCHLIFEDHIYEKLDAITDEENDMLDLAYGLTDRSRLGCQICLTKSMDNMTVRVPETVADARQSIDVGKTS

Target ORF information:

RefSeq Version	NM_004109.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ferredoxin 1 (FDX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004109.5

ORF Insert Sequence:

ATGGCTGCCG CTGGGGGCGC CCGGCTGCTG CGCGCCGCTT CTGCTGTCCT CGGCGGCCCG 
GCCGGCCGGT GGCTGCACCA CGCTGGGTCC CGCGCTGGAT CCAGCGGCCT GCTGAGGAAC 
CGGGGGCCGG GCGGGAGCGC GGAGGCGAGC CGGTCGCTGA GCGTGTCGGC GCGGGCCCGG 
AGCAGCTCAG AAGATAAAAT AACAGTCCAC TTTATAAACC GTGATGGTGA AACATTAACA 
ACCAAAGGAA AAGTTGGTGA TTCTCTGCTA GATGTTGTGG TTGAAAATAA TCTAGATATT 
GATGGCTTTG GTGCATGTGA GGGAACCCTG GCTTGTTCAA CCTGTCACCT CATCTTTGAA 
GATCACATAT ATGAGAAGTT AGATGCAATC ACTGATGAGG AGAATGACAT GCTCGATCTG 
GCATATGGAC TAACAGACAG ATCACGGTTG GGCTGCCAAA TCTGTTTGAC AAAATCTATG 
GACAATATGA CTGTTCGAGT GCCTGAAACA GTGGCTGATG CCAGACAATC CATTGATGTG 
GGCAAGACCT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin.
Biochemistry56(43)5786-5797(2017 10)
Zhu Q,Mak PJ,Tuckey RC,Kincaid JR

Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.
Biochemistry56(17)2282-2293(2017 05)
Peng HM,Auchus RJ

Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron-Sulfur Cluster Biosynthesis.
Biochemistry56(3)487-499(2017 01)
Cai K,Tonelli M,Frederick RO,Markley JL

Association between CCDC132, FDX1 and TNFSF13 gene polymorphisms and the risk of IgA nephropathy.
Nephrology (Carlton, Vic.)20(12)908-15(2015 Dec)
Niu D,Ren Y,Xie L,Sun J,Lu W,Hao Y,Zhang Y,Yin A,Li H,Lv J,Li S

Genetic polymorphisms in TNFSF13 and FDX1 are associated with IgA nephropathy in the Han Chinese population.
Human immunology76(11)831-5(2015 Nov)
Niu D,Gao Y,Xie L,Sun J,Lu W,Jin G,Hao Y,Zhang Y,Yin A,Geng Y,Zhang W,Chen C,Li S

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FDX1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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